DT-Web

DB00715 - Paroxetine


Identification
Name Paroxetine
Accession Number DB00715
Type small molecule
Description Paroxetine hydrochloride and paroxetine mesylate belong to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache (see Toxicity section below for a complete listing of side effects). Side effects generally occur during the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Paroxetine hydrochloride and mesylate are considered therapeutic alternatives rather than generic equivalents by the US Food and Drug Administration (FDA); both agents contain the same active moiety (i.e. paroxetine), but are formulated as different salt forms. Clinical studies establishing the efficacy of paroxetine in various conditions were performed using paroxetine hydrochloride. Since both agents contain the same active moiety, the clinical efficacy of both agents is thought to be similar. Paroxetine may be used to treat major depressive disorder (MDD), panic disorder with or without agoraphobia, obsessive-compulsive disorder (OCD), social anxiety disorder (social phobia), generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD) and premenstrual dysphoric disorder (PMDD). Paroxetine has the most evidence supporting its use for anxiety-related disorders of the SSRIs. It has the greatest anticholinergic activity of the agents in this class and compared to other SSRIs, paroxetine may cause greater weight gain, sexual dysfunction, sedation and constipation.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 329.3654
Groups approved
Monoisotopic Weight 329.142721716
Pharmacology
Indication Labeled indications include: major depressive disorder (MDD), panic disorder with or without agoraphobia, obsessive-compulsive disorder (OCD), social anxiety disorder (social phobia), generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Unlabeled indications include: eating disorders, impulse control disorders, vasomotor symptoms of menopause, obsessive-compulsive disorder (OCD) in children, and mild dementia-associated agitation in nonpsychotic individuals. Brisdelle, which consists of paroxetine mesylate is indicated for the treatment of moderate to severe vasomotor symptoms (like hot flashes) associated with menopause.
Mechanism of action Paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake. Paroxetine likely inhibits the reuptake of serotonin at the neuronal membrane, enhances serotonergic neurotransmission by reducing turnover of the neurotransmitter, therefore it prolongs its activity at synaptic receptor sites and potentiates 5-HT in the CNS; paroxetine is more potent than both sertraline and fluoxetine in its ability to inhibit 5-HT reuptake. Compared to the tricyclic antidepressants, SSRIs have dramatically decreased binding to histamine, acetylcholine, and norepinephrine receptors. The mechanism of action for the treatment of vasomotor symptoms is unknown.
Absorption Paroxetine hydrochloride is slowly, but completely absorbed following oral administration. Paroxetine mesylate salt is also completely absorbed after oral dosing. The oral bioavailability appears to be low due to extensive first-pass metabolism. Paroxetine hydrochloride oral tablets and suspension are reportedly bioequivalent. Absorption of either salt form is not substantially affected by food. Peak concentrations of Brisbelle (mesylate salt) were reached at 6 hours (3 to 8 hours range). Steady state Cmax was 13.10 ng/mL. The steady state AUC (0-last) was 237 hr*ng/mL. Paroxetine mesylate generally follows non-linear pharmacokinetics because CYP2D6, the enzyme that is part responisible for paroxetine metabolism, is readily saturable.
Protein binding ~ 95% bound to plasma proteins.
Biotransformation Paroxetine is extensively metabolized after oral administration, likely in the liver. The main metabolites are polar and conjugated products of oxidation and methylation, which are readily eliminated by the body. The predominant metabolites are glucuronic acid and sulfate conjugates. Paroxetine metabolites do not possess significant pharmacologic activity (less than 2% that of parent compound). Paroxetine is metabolized by cytochrome P450 (CYP) 2D6. Enzyme saturation appears to account for the nonlinear pharmacokinetics observed with increasing dose and duration of therapy.
Route of elimination Approximately 64% of a 30 mg oral solution of paroxetine was excreted in the urine with 2% as the parent compound and 62% as metabolites. Approximately 36% of the dose was excreted in the feces (via bile), mostly as metabolites and less than 1% as parent compound.
Toxicity LD50=500mg/kg (orally in mice). Symptoms of overdose include: coma, dizziness, drowsiness, facial flushing, nausea, sweating, tremor, vomiting. Side effects include: nervous system effects such as asthenia, somnolence, dizziness, insomnia, tremor, and nervousness; GI effects such as nausea, decreased appetite, constipation, diarrhea, and dry mouth; impotence, ejaculatory dysfunction (principally ejaculatory delay), and other male genital disorders; female genital disorders (principally anorgasmia or difficulty reaching climax/orgasm); and sweating. Discontinuation syndrome may occur with abrupt withdrawal. Symptoms of discontinuation syndrome include flu-like symptoms, insomnia, nausea, imbalance, sensory changes, and hyperactivity.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The SSRI, paroxetine, increases the effect of the anticoagulant, acenocoumarol.
Almotriptan Increased risk of CNS adverse effects
Amphetamine Risk of serotoninergic syndrome
Anisindione The SSRI, paroxetine, increases the effect of the anticoagulant, anisindione.
Asenapine Paroxetine is a substrate of CYP2D6 and concomitant therapy with asenapine (CYP2D6 inhibitor) increases concentrations of paroxetine 2-fold. May require dosing adjustments.
Atomoxetine The CYP2D6 inhibitor, paroxetine, may increase the effect and toxicity of atomoxetine.
Benzphetamine Amphetamines may enhance the adverse/toxic effect of Serotonin Modulators. The risk of serotonin syndrome may be increased. Monitor patients closely for signs and symptoms of serotonin syndrome (e.g., agitation, tremor, tachycardia, etc.) when using amphetamines and serotonin modulators in combination.
Carvedilol The SSRI, paroxetine, may increase the bradycardic effect of the beta-blocker, carvedilol.
Desvenlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dexfenfluramine Risk of serotoninergic syndrome
Dextroamphetamine Risk of serotoninergic syndrome
Dextromethorphan Combination associated with possible serotoninergic syndrome
Dicumarol The SSRI, paroxetine, increases the effect of anticoagulant, dicumarol.
Diethylpropion Risk of serotoninergic syndrome
Dihydrocodeine Opioid analgesics may enhance the 5HT effects of SSRIs to cause serotonin syndrome. It is recommended to monitor therapy.
Eletriptan Increased risk of CNS adverse effects
Fenfluramine Risk of serotoninergic syndrome
Frovatriptan Increased risk of CNS adverse effects
Galantamine Paroxetine increases the effect and toxicity of galantamine
Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Iloperidone Paroxetine is a strong CYP2D6 inhibitor that increases serum concentration of iloperidone and likelihood of observing adverse effects such as QT prolongation. Reduce dose of iloperidone by 50%
Isocarboxazid Possible severe adverse reaction with this combination
Ketoprofen Concomitant therapy may result in additive antiplatelet effects and increase the risk of bleeding. Monitor for increased risk of bleeding during concomitant therapy.
Linezolid Combination associated with possible serotoninergic syndrome
Mazindol Risk of serotoninergic syndrome
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Methamphetamine Risk of serotoninergic syndrome
Metoprolol The SSRI increases the effect of the beta-blocker
Moclobemide Possible severe adverse reaction with this combination
Naratriptan Increased risk of CNS adverse effects
Oxycodone Increased risk of serotonin syndrome
Phendimetrazine Risk of serotoninergic syndrome
Phenelzine Possible severe adverse reaction with this combination
Phentermine Risk of serotoninergic syndrome
Phenylpropanolamine Risk of serotoninergic syndrome
Pimozide Increased risk of cardiotoxicity and arrhythmias.
Propafenone Paroxetine may increase the effect and toxicity of propafenone.
Propranolol The SSRI, paroxetine, may increase the bradycardic effect of the beta-blocker, propranolol.
Rasagiline Possible severe adverse reaction with this combination
Risperidone The SSRI, paroxetine, increases the effect and toxicity of risperidone.
Rizatriptan Increased risk of CNS adverse effects
Selegiline Possible severe adverse reaction with this combination
Sibutramine Risk of serotoninergic syndrome
St. John's Wort St. John's Wort increases the effect and toxicity of the SSRI, paroxetine.
Sumatriptan Increased risk of CNS adverse effects
Tamoxifen Paroxetine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Tamsulosin Paroxetine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Paroxetine is initiated, discontinued, or dose changed.
Terbinafine Terbinafine may reduce the metabolism and clearance of Paroxetine. Consider alternate therapy or monitor for therapeutic/adverse effects of Paroxetine if Terbinafine is initiated, discontinued or dose changed.
Tetrabenazine Paroxetine is a strong CYP2D6 inhibitor thus increasing half life of dihydrotetrabenazine moieties. Dose of tetrabenazine should be reduced
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Tiaprofenic acid Additive antiplatelet effects increase the risk of bleeding. Consider alternate therapy or monitor for increased bleeding.
Tipranavir Tipranavir increases the concentration of Paroxetine. The Paroxetine dose may require an adjustment.
Tolmetin Increased antiplatelet effects may enhance the risk of bleeding. Alternate therapy may be considered or monitor for inreased bleeding during concomitant therapy.
Tolterodine Paroxetine may decrease the metabolism and clearance of Tolterodine. Monitor for adverse/toxic effects of Tolterodine.
Tramadol Tramadol may increase the risk of serotonin syndrome and seizures. Paroxetine may decrease the effect of Tramadol by decreasing active metabolite production.
Tranylcypromine Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Treprostinil The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Paroxetine. Monitor for increased bleeding during concomitant thearpy.
Trimipramine The SSRI, Paroxetine, may decrease the metabolism and clearance of Trimipramine. Increased risk of serotonin syndrome. Monitor for changes in Trimipramine efficacy and toxicity if Paroxetine is initiated, discontinued or dose changed.
Triprolidine The CNS depressants, Triprolidine and Paroxetine, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Venlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Warfarin The SSRI, paroxetine, increases the effect of the anticoagulant, warfarin.
Zolmitriptan Use of two serotonin modulators, such as zolmitriptan and paroxetine, may increase the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Zuclopenthixol Paroxetine, a strong CYP2D6 inhibitor, may increase the serum concentration of zuclopenthixol by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zuclopenthixol if paroxetine is initiated, discontinued or dose changed.
Food Interactions
  • Take without regard to meals. Avoid alcohol.

Targets


Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action yes
Actions inhibitor
References
  • Scholze P, Zwach J, Kattinger A, Pifl C, Singer EA, Sitte HH: Transporter-mediated release: a superfusion study on human embryonic kidney cells stably expressing the human serotonin transporter. J Pharmacol Exp Ther. 2000 Jun;293(3):870-8. - Pubmed
  • Preuss UW, Soyka M, Bahlmann M, Wenzel K, Behrens S, de Jonge S, Kruger M, Bondy B: Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity. Psychiatry Res. 2000 Sep 25;96(1):51-61. - Pubmed
  • Haughey HM, Fleckenstein AE, Metzger RR, Hanson GR: The effects of methamphetamine on serotonin transporter activity: role of dopamine and hyperthermia. J Neurochem. 2000 Oct;75(4):1608-17. - Pubmed
  • Pollock BG, Ferrell RE, Mulsant BH, Mazumdar S, Miller M, Sweet RA, Davis S, Kirshner MA, Houck PR, Stack JA, Reynolds CF, Kupfer DJ: Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology. 2000 Nov;23(5):587-90. - Pubmed
  • Wihlback AC, Sundstrom-Poromaa I, Allard P, Mjorndal T, Spigset O, Backstrom T: Influence of postmenopausal hormone replacement therapy on platelet serotonin uptake site and serotonin 2A receptor binding. Obstet Gynecol. 2001 Sep;98(3):450-7. - Pubmed
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score 0.4427
Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action unknown
Actions inhibitor
References
  • Rubin RT: Paroxetine binding to the rat norepinephrine transporter in vivo. Biol Psychiatry. 2000 Nov 1;48(9):954-6. - Pubmed
  • Gilmor ML, Owens MJ, Nemeroff CB: Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine. Am J Psychiatry. 2002 Oct;159(10):1702-10. - Pubmed
  • Nemeroff CB, Owens MJ: Neuropharmacology of paroxetine. Psychopharmacol Bull. 2003 Spring;37 Suppl 1:8-18. - Pubmed
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score 0.5551
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action unknown
Actions other/unknown
References
  • Bixo M, Allard P, Backstrom T, Mjorndal T, Nyberg S, Spigset O, Sundstrom-Poromaa I: Binding of [3H]paroxetine to serotonin uptake sites and of [3H]lysergic acid diethylamide to 5-HT2A receptors in platelets from women with premenstrual dysphoric disorder during gonadotropin releasing hormone treatment. Psychoneuroendocrinology. 2001 Aug;26(6):551-64. - Pubmed
  • Meyer JH, Kapur S, Eisfeld B, Brown GM, Houle S, DaSilva J, Wilson AA, Rafi-Tari S, Mayberg HS, Kennedy SH: The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study. Am J Psychiatry. 2001 Jan;158(1):78-85. - Pubmed
DTHybrid score 0.3416
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action no
Actions antagonist
References
  • Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score 0.9495
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action no
Actions antagonist
References
  • Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score 0.8097
Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action no
Actions antagonist
References
  • Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score 0.8176
Muscarinic acetylcholine receptor M4
Name Muscarinic acetylcholine receptor M4
Gene Name CHRM4
Pharmacological action no
Actions antagonist
References
  • Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score 0.5895
Muscarinic acetylcholine receptor M5
Name Muscarinic acetylcholine receptor M5
Gene Name CHRM5
Pharmacological action no
Actions antagonist
References
  • Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score 0.4905

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Urichuk L, Prior TI, Dursun S, Baker G: Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions. Curr Drug Metab. 2008 Jun;9(5):410-8. - Pubmed
  • Baumann P: Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996 Dec;31(6):444-69. - Pubmed
  • Ozdemir V, Naranjo CA, Herrmann N, Reed K, Sellers EM, Kalow W: Paroxetine potentiates the central nervous system side effects of perphenazine: contribution of cytochrome P4502D6 inhibition in vivo. Clin Pharmacol Ther. 1997 Sep;62(3):334-47. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6928
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4876
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3498
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3507

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Weiss J, Dormann SM, Martin-Facklam M, Kerpen CJ, Ketabi-Kiyanvash N, Haefeli WE: Inhibition of P-glycoprotein by newer antidepressants. J Pharmacol Exp Ther. 2003 Apr;305(1):197-204. - Pubmed
DTHybrid score 0.4804

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.5719
6016 Cytochrome P450 2C19 CYP2C19 0.3441
4200 Cytochrome P450 1A2 CYP1A2 0.3053
492 Histamine H1 receptor HRH1 0.2616
713 Sodium-dependent dopamine transporter SLC6A3 0.2264
556 Alpha-1A adrenergic receptor ADRA1A 0.2229
4118 Cytochrome P450 3A5 CYP3A5 0.203
831 D(2) dopamine receptor DRD2 0.2028
590 5-hydroxytryptamine 2C receptor HTR2C 0.1847
6013 Cytochrome P450 2E1 CYP2E1 0.1793
6107 Cytochrome P450 3A7 CYP3A7 0.1487
23 D(1A) dopamine receptor DRD1 0.1378
318 Alpha-2A adrenergic receptor ADRA2A 0.1256
320 5-hydroxytryptamine 1A receptor HTR1A 0.121
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1208
632 Alpha-1B adrenergic receptor ADRA1B 0.119
5718 Cytochrome P450 2A6 CYP2A6 0.1084
587 Serum albumin ALB 0.1031
3923 Cholinesterase BCHE 0.1026
6024 Cytochrome P450 1A1 CYP1A1 0.101
789 Alpha-1D adrenergic receptor ADRA1D 0.0935
436 5-hydroxytryptamine 2B receptor HTR2B 0.0901
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0876
638 D(3) dopamine receptor DRD3 0.0813
20 Prostaglandin G/H synthase 1 PTGS1 0.0807
629 Alpha-2B adrenergic receptor ADRA2B 0.0798
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0783
432 D(4) dopamine receptor DRD4 0.0775
6145 Solute carrier family 22 member 1 SLC22A1 0.0763
378 Alpha-2C adrenergic receptor ADRA2C 0.0748
3941 Amine oxidase [flavin-containing] A MAOA 0.0729
6106 Cytochrome P450 2C18 CYP2C18 0.0721
6144 Solute carrier family 22 member 2 SLC22A2 0.0636
131 Synaptic vesicular amine transporter SLC18A2 0.0593
3939 Amine oxidase [flavin-containing] B MAOB 0.0571
341 5-hydroxytryptamine 3 receptor HTR3A 0.057
716 5-hydroxytryptamine 7 receptor HTR7 0.0564
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0544
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0528
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0514
118 Organic cation/carnitine transporter 2 SLC22A5 0.0513
725 5-hydroxytryptamine 1D receptor HTR1D 0.0504
885 5-hydroxytryptamine 1B receptor HTR1B 0.0503
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0503
766 Beta-2 adrenergic receptor ADRB2 0.0497
193 Beta-1 adrenergic receptor ADRB1 0.0483
1256 5-hydroxytryptamine 6 receptor HTR6 0.0481
163 D(1B) dopamine receptor DRD5 0.0478
833 Organic cation/carnitine transporter 1 SLC22A4 0.0473
862 Multidrug resistance-associated protein 1 ABCC1 0.0444
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0433
696 Kappa-type opioid receptor OPRK1 0.0426
465 Calmodulin CALM1 0.0413
467 Delta-type opioid receptor OPRD1 0.041
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0409
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0397
847 Mu-type opioid receptor OPRM1 0.0385
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0382
290 Prostaglandin G/H synthase 2 PTGS2 0.0373
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0372
528 5-hydroxytryptamine 1E receptor HTR1E 0.0368
6147 Solute carrier family 22 member 3 SLC22A3 0.036
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0351
1898 Cytochrome P450 1B1 CYP1B1 0.0337
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0332
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0332
2129 Sucrase-isomaltase, intestinal SI 0.0331
124 Histamine H2 receptor HRH2 0.033
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0329
1729 Solute carrier family 22 member 6 SLC22A6 0.0327
6432 Transporter snf 0.0324
94 5-hydroxytryptamine 4 receptor HTR4 0.0309
1656 CYP2B protein CYP2B 0.0307
474 Acetylcholinesterase ACHE 0.0307
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0296
776 Bile salt export pump ABCB11 0.0292
3811 Cytochrome P450 19A1 CYP19A1 0.0289
174 Sigma 1-type opioid receptor SIGMAR1 0.0283
6182 Cytochrome P450 2J2 CYP2J2 0.0282
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0282
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.026
136 Estrogen receptor ESR1 0.0254
2164 Multidrug resistance-associated protein 4 ABCC4 0.0238
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0231
731 HIV-1 protease HIV-1 protease 0.0229
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0226
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0226
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0219
6142 Solute carrier family 22 member 8 SLC22A8 0.0219
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0216
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0213
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.021
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0209
122 P2Y purinoceptor 12 P2RY12 0.0201
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0201
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0198
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0188
6143 Solute carrier family 22 member 7 SLC22A7 0.0184
891 Dihydropteroate synthase folP 0.0183
5359 Dihydropteroate synthase folP 0.0183
7175 Dihydropteroate synthase sulI 0.0183
871 Glucocorticoid receptor NR3C1 0.0173
468 Cytochrome P450 4A11 CYP4A11 0.0172
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0171
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0163
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0163
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.016
1360 Sphingomyelin phosphodiesterase SMPD1 0.0159
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0158
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0157
260 Cytochrome P450 51 ERG11 0.0157
761 Cytochrome P450 51 ERG11 0.0157
3163 Cytochrome P450 51 cyp51 0.0157
1636 Trace amine-associated receptor 1 TAAR1 0.0152
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0152
380 Cytochrome P450 17A1 CYP17A1 0.0151
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0151
1618 High affinity nerve growth factor receptor NTRK1 0.015
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0149
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0149
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0148
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0148
4120 NADPH--cytochrome P450 reductase POR 0.0145
146 Androgen receptor AR 0.0144
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.014
70 Type-1 angiotensin II receptor AGTR1 0.014
504 Mast/stem cell growth factor receptor KIT 0.0139
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0136
6031 Cytochrome P450 3A43 CYP3A43 0.0135
4604 Liver carboxylesterase 1 CES1 0.0135
723 Cytosolic phospholipase A2 PLA2G4A 0.0134
817 DNA topoisomerase 2-alpha TOP2A 0.0133
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0132
1517 Beta-3 adrenergic receptor ADRB3 0.0131
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.013
1024 Solute carrier family 22 member 11 SLC22A11 0.0127
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0126
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0124
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0124
6136 Multidrug resistance-associated protein 5 ABCC5 0.0124
482 Glycine receptor subunit alpha-1 GLRA1 0.0123
844 Epidermal growth factor receptor EGFR 0.0123
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0123
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0122
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0121
6137 Multidrug resistance-associated protein 6 ABCC6 0.012
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0116
6141 Sodium/bile acid cotransporter SLC10A1 0.0115
1757 Myeloperoxidase MPO 0.0114
869 Estrogen receptor beta ESR2 0.0112
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0111
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0111
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0108
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0107
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0106
6148 Multidrug resistance-associated protein 7 ABCC10 0.0105
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0104
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0102
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0099
365 Dihydrofolate reductase DHFR 0.0098
2381 Dihydrofolate reductase DFR1 0.0098
2833 Dihydrofolate reductase Not Available 0.0098
2931 Dihydrofolate reductase folA 0.0098
3544 Dihydrofolate reductase folA 0.0098
3682 Dihydrofolate reductase folA 0.0098
6642 Dihydrofolate reductase folA 0.0098
6756 Dihydrofolate reductase dfrA 0.0098
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0098
921 Glutamate receptor 2 GRIA2 0.0098
161 Tubulin beta chain TUBB 0.0096
312 Tubulin beta chain TUB2 0.0096
811 Translocator protein TSPO 0.0094
164 Histamine H4 receptor HRH4 0.0094
319 Opioid receptor, sigma 1 OPRS1 0.0093
1192 Sulfotransferase 1A1 SULT1A1 0.0092
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0092
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0092
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0092
904 Glutathione S-transferase P GSTP1 0.0091
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.009
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.009
407 Vascular endothelial growth factor receptor 2 KDR 0.009
952 Dipeptidyl peptidase 4 DPP4 0.009
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0088
4116 Dihydropteroate synthetase Not Available 0.0087
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0087
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0086
6085 Fatty acid-binding protein, intestinal FABP2 0.0086
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0086
1010 Cytochrome P450 51A1 CYP51A1 0.0086
614 Progesterone receptor PGR 0.0086
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0085
756 Sex hormone-binding globulin SHBG 0.0084
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0084
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0083
6102 Arylamine N-acetyltransferase 2 NAT2 0.0082
26 Vascular endothelial growth factor receptor 3 FLT4 0.0082
29 Tubulin beta-1 chain TUBB1 0.0081
228 Beta platelet-derived growth factor receptor PDGFRB 0.008
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.008
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0079
6220 Aryl hydrocarbon receptor AHR 0.0079
32 Vascular endothelial growth factor receptor 1 FLT1 0.0078
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0076
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0076
923 Glutamate receptor 3 GRIA3 0.0075
738 Monocarboxylate transporter 1 SLC16A1 0.0075
2981 Phospholipase A2, membrane associated PLA2G2A 0.0075
427 Substance-P receptor TACR1 0.0073
2112 Toll-like receptor 9 TLR9 0.0072
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0072
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0072
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0071
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0071
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0071
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0071
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0071
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0071
244 Angiotensin-converting enzyme ACE 0.0071
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0071
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0071
6138 Multidrug resistance protein 3 ABCB4 0.0071
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.007
4203 Histamine N-methyltransferase HNMT 0.007
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.007
777 Tumor necrosis factor TNF 0.007
24 Thymidylate synthase TMP1 0.0069
359 Thymidylate synthase TYMS 0.0069
2626 Thymidylate synthase thyA 0.0069
2729 Thymidylate synthase thyA 0.0069
5352 Thymidylate synthase THYA 0.0069
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0069
373 Transthyretin TTR 0.0068
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0067
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0067
737 Mineralocorticoid receptor NR3C2 0.0066
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0066
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0065
3810 Catechol O-methyltransferase COMT 0.0065
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0065
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0065
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0065
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0065
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0065
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0065
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0063
133 Dihydropterate synthase sulI 0.0063
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0063
537 ATP synthase delta chain, mitochondrial ATP5D 0.0061
88 Retinoic acid receptor RXR-beta RXRB 0.0061
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.006
1541 Metalloproteinase mmp20 0.006
295 Carbonic anhydrase 1 CA1 0.0059
1353 DNA topoisomerase 1 TOP1 0.0059
3552 DNA topoisomerase 1 topA 0.0059
818 50S ribosomal protein L10 rplJ 0.0059
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0059
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0057
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0057
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0057
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0056
1178 Adenosine A2a receptor ADORA2A 0.0055
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0055
1629 Transcription factor AP-1 JUN 0.0055
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0055
6014 Cytochrome P450 2A13 CYP2A13 0.0053
275 Arachidonate 5-lipoxygenase ALOX5 0.0052
1275 Estrogen sulfotransferase SULT1E1 0.0052
705 Glutamate receptor 1 GRIA1 0.0051
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0051
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0051
3947 Xanthine dehydrogenase/oxidase XDH 0.0051
208 DNA-directed RNA polymerase beta' chain rpoC 0.0049
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0049
828 Phenylalanine-4-hydroxylase PAH 0.0049
3109 Phenylalanine-4-hydroxylase phhA 0.0049
3932 Glutathione S-transferase A2 GSTA2 0.0049
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0049
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0049
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
1262 Corticotropin-lipotropin POMC 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
165 FL cytokine receptor FLT3 0.0047
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0047
4103 Proteasome subunit beta type 2 PSMB2 0.0046
4102 Proteasome subunit beta type 5 PSMB5 0.0046
4101 Proteasome subunit beta type 1 PSMB1 0.0046
84 Nuclear receptor 0B1 NR0B1 0.0046
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0046
1050 Bile salt sulfotransferase SULT2A1 0.0046
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0045
527 Prostacyclin receptor PTGIR 0.0045
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0045
162 Retinoic acid receptor gamma-1 RARG 0.0045
823 Fibroblast growth factor receptor 2 FGFR2 0.0045
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0044
49 Endothelin B receptor EDNRB 0.0044
780 Retinoic acid receptor RXR-gamma RXRG 0.0043
3426 Glutamine synthetase glnA 0.0043
3987 Glutamine synthetase GLUL 0.0043
1630 Integrin beta-2 ITGB2 0.0043
3856 Fibroblast growth factor receptor 3 FGFR3 0.0042
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0042
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0042
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0042
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0042
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0042
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0041
592 Carbonic anhydrase 4 CA4 0.0041
469 Annexin A1 ANXA1 0.0041
3809 Estrogen-related receptor gamma ESRRG 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
581 Cytochrome P450 2R1 CYP2R1 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
5300 Antigen peptide transporter 1 TAP1 0.004
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.004
518 Peroxidase/catalase T katG 0.004
1992 Vitamin D-binding protein GC 0.0039
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0038
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
563 Thyroid peroxidase TPO 0.0038
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0038
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0038
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0038
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0038
7 Nitric oxide synthase, inducible NOS2 0.0038
4148 Serine/threonine-protein kinase mTOR MTOR 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0038
1852 Microtubule-associated protein 2 MAP2 0.0037
1648 Elastin ELN 0.0037
16 Adenosine A1 receptor ADORA1 0.0037
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0037
4122 Histone deacetylase 2 HDAC2 0.0037
130 Prostacyclin synthase PTGIS 0.0037
5787 Angiopoietin-1 receptor TEK 0.0036
6020 Aldehyde oxidase AOX1 0.0036
558 Solute carrier family 12 member 1 SLC12A1 0.0036
3086 Plasmepsin-2 Not Available 0.0036
6146 High affinity copper uptake protein 1 SLC31A1 0.0036
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0036
6174 50S ribosomal protein L32 rpmF 0.0036
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
54 Prothrombin F2 0.0035
6151 Monocarboxylate transporter 10 SLC16A10 0.0034
183 Vascular endothelial growth factor A VEGFA 0.0034
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0034
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0034
239 Coagulation factor X F10 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
594 Thyroxine-binding globulin SERPINA7 0.0034
273 Apoptosis regulator Bcl-2 BCL2 0.0034
6126 Carbonic anhydrase 7 CA7 0.0034
6506 Stathmin-4 STMN4 0.0033
173 Toll-like receptor 7 TLR7 0.0033
5880 Thrombopoietin receptor MPL 0.0033
229 Retinoic acid receptor beta RARB 0.0032
634 Squalene monooxygenase SQLE 0.0031
7196 Squalene monooxygenase ERG1 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
6149 Solute carrier family 22 member 10 SLC22A10 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
758 Thyroid hormone receptor alpha THRA 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
357 Carbonic anhydrase 2 CA2 0.0031
2539 Tubulin alpha-1 chain TUBA4A 0.0031
459 Retinoic acid receptor RXR-alpha RXRA 0.0031
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0031
4311 tRNA TRDMT1 0.003
4325 tRNA trmD 0.003
4328 tRNA trmD 0.003
6103 Arylamine N-acetyltransferase 1 NAT1 0.003
976 Platelet glycoprotein IX GP9 0.003
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0029
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0029
856 Vitamin D3 receptor VDR 0.0029
683 Potassium transporter GK0582 0.0029
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
565 Extracellular calcium-sensing receptor CASR 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
5934 Cytochrome P450 26A1 CYP26A1 0.0028
814 Ryanodine receptor 1 RYR1 0.0028
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0028
6824 Tyrosine-protein kinase Lyn LYN 0.0028
511 5-hydroxytryptamine 1F receptor HTR1F 0.0028
751 Potassium channel subfamily K member 6 KCNK6 0.0028
5798 Mitogen-activated protein kinase 11 MAPK11 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
1932 Apolipoprotein E APOE 0.0028
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
4773 Deoxycytidine kinase DCK 0.0027
936 Ephrin type-A receptor 2 EPHA2 0.0027
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0027
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0027
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0026
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0026
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0026
571 Melatonin receptor type 1A MTNR1A 0.0026
362 Melatonin receptor type 1B MTNR1B 0.0026
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6048 Troponin C, skeletal muscle TNNC2 0.0026
992 Protein tyrosine kinase 2 beta PTK2B 0.0026
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0026
172 Potassium channel subfamily K member 1 KCNK1 0.0025
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
1196 Complement decay-accelerating factor CD55 0.0025
719 Retinoic acid receptor responder protein 1 RARRES1 0.0025
770 Retinoic acid-induced protein 3 GPRC5A 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
2207 Rhodopsin RHO 0.0025
908 Glutathione S-transferase theta-1 GSTT1 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0024
153 Dopamine beta-hydroxylase DBH 0.0024
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0024
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0024
199 Monocarboxylate transporter 8 SLC16A2 0.0024
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0024
6044 Serum paraoxonase/lactonase 3 PON3 0.0024
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0024
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
3611 Cytidine deaminase cdd 0.0024
3707 Cytidine deaminase cdd 0.0024
4211 Cytidine deaminase CDA 0.0024
5923 Microtubule-associated protein tau MAPT 0.0024
5924 Microtubule-associated protein 4 MAP4 0.0024
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0024
2599 Tyrosine-protein kinase HCK HCK 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0023
5816 Cadherin-5 CDH5 0.0023
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0023
232 Corticosteroid-binding globulin SERPINA6 0.0023
1291 cAMP response element-binding protein CREB1 0.0023
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0023
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0023
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0023
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0023
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0023
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0023
572 Integrin alpha-L ITGAL 0.0023
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0022
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0022
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0022
4217 Telomerase reverse transcriptase TERT 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0022
291 Nitric-oxide synthase, endothelial NOS3 0.0022
3957 Adenosine deaminase ADA 0.0022
3937 Fatty-acid amide hydrolase FAAH 0.0022
569 Retinal dehydrogenase 2 ALDH1A2 0.0022
267 Plasminogen activator inhibitor 1 SERPINE1 0.0022
2808 Chloramphenicol acetyltransferase 3 cat3 0.0022
2216 Fibroblast growth factor receptor 4 FGFR4 0.0022
4210 Toll-like receptor 4 TLR4 0.0022
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0021
106 Cannabinoid receptor 2 CNR2 0.0021
611 Retinal dehydrogenase 1 ALDH1A1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
144 Hemoglobin subunit alpha HBA1 0.002
6459 Glycodelin PAEP 0.002
3808 Dihydropteroate synthase 2 folP2 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
3601 Dihydropteroate synthase 1 folP1 0.002
3807 Dihydropteroate synthase 1 folP1 0.002
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
2417 Chloramphenicol acetyltransferase cat 0.002
3278 Chloramphenicol acetyltransferase cat 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6221 Steroid hormone receptor ERR1 ESRRA 0.002
2810 Dr hemagglutinin structural subunit draA 0.002
68 Cannabinoid receptor 1 CNR1 0.002
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.002
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.002
1374 Natriuretic peptides B NPPB 0.002
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.002
489 Monocarboxylate transporter 2 SLC16A7 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
1827 Gap junction alpha-1 protein GJA1 0.002
1908 Vascular cell adhesion protein 1 VCAM1 0.002
444 Alcohol dehydrogenase 1B ADH1B 0.0019
1039 Histone deacetylase 9 HDAC9 0.0019
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0019
268 Adenosine A2b receptor ADORA2B 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
605 Fumarate reductase flavoprotein subunit frdA 0.0019
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0019
3673 Fumarate reductase flavoprotein subunit fccA 0.0019
4912 Fumarate reductase flavoprotein subunit ifcA 0.0019
6549 Fumarate reductase flavoprotein subunit frdA 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
2021 Thrombomodulin THBD 0.0019
284 DNA-directed RNA polymerase beta chain rpoB 0.0018
5773 DNA-directed RNA polymerase beta chain rpoB 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0018
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0018
1268 Neuropeptide S receptor NPSR1 0.0018
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0018
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
251 Alcohol dehydrogenase 1A ADH1A 0.0018
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0018
1341 Histamine H3 receptor HRH3 0.0018
2320 Thymidine kinase, cytosolic TK1 0.0017
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0017
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
820 Glycine receptor subunit alpha-2 GLRA2 0.0017
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0017
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0017
6073 Potassium channel subfamily K member 9 KCNK9 0.0017
6072 Potassium channel subfamily K member 3 KCNK3 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
4192 DNA topoisomerase 2-beta TOP2B 0.0016
6211 Tubulin epsilon chain TUBE1 0.0016
6212 Tubulin gamma-1 chain TUBG1 0.0016
6210 Tubulin delta chain TUBD1 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
517 Alcohol dehydrogenase 1C ADH1C 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
760 Fibroblast growth factor 1 FGF1 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0015
6165 Copper-transporting ATPase 1 ATP7A 0.0015
6218 Pannexin-1 PANX1 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6677 Myelin P2 protein PMP2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
1864 RET proto-oncogene RET 0.0015
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0014
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0014
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0014
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0014
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0014
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0014
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
6168 Solute carrier family 22 member 16 SLC22A16 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0014
2232 Interleukin-5 IL5 0.0014
1593 Mucin-2 MUC2 0.0014
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
3404 Exotoxin A eta 0.0013
3221 Cytochrome c4 cc4 0.0013
3917 Methylenetetrahydrofolate reductase MTHFR 0.0013
6167 Organic solute transporter subunit beta OSTB 0.0013
6166 Organic solute transporter subunit alpha OSTA 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
1792 Tissue-type plasminogen activator PLAT 0.0013
896 Glutathione S-transferase Mu 1 GSTM1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
76 Nitric-oxide synthase, brain NOS1 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0012
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6859 Protein S100-A4 S100A4 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0011
4948 Cytochrome c-553 Not Available 0.0011
4923 Cytochrome c3 DvMF_2499 0.0011
4945 Cytochrome c3 Not Available 0.0011
4949 Cytochrome c3 DVU_3171 0.0011
4968 Cytochrome c3 cytc3 0.0011
4997 Cytochrome c3 SO_2727 0.0011
5219 Cytochrome c3 cyd 0.0011
4902 Nine-heme cytochrome c Ddes_2038 0.0011
3189 High-molecular-weight cytochrome c hmcA 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
3913 Glutamic acid decarboxylase GAD65 0.0011
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.001
1483 Membrane copper amine oxidase AOC3 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
233 Potassium channel subfamily K member 2 KCNK2 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
735 Alanine aminotransferase 1 GPT 0.0009
3904 Alanine aminotransferase 2 GPT2 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
33 Cystine/glutamate transporter SLC7A11 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
3830 Calreticulin CALR 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
1507 Cytochrome c CYCS 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6043 Putative G-protein coupled receptor 44 GPR44 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
4954 Soluble cytochrome b558 Not Available 0.0007
4925 Cytochrome c-type protein SHP shp 0.0007
4916 Cyanoglobin glbN 0.0007
4947 Bacterial hemoglobin vhb 0.0007
4915 Cytochrome c-550 psbV 0.0007
4959 Cytochrome c-550 psbV 0.0007
5216 Cytochrome c-550 psbV 0.0007
4934 Cytochrome c-551 nirM 0.0007
5218 Cytochrome c-551 nirM 0.0007
4975 Cytochrome c-556 RPA3973 0.0007
4943 Cytochrome c6 petJ 0.0007
4994 Hemoglobin-like protein HbO glbO 0.0007
4905 Cytochrome c2 Not Available 0.0007
4939 Cytochrome c2 cycA 0.0007
4964 Cytochrome c2 cycA 0.0007
4979 Cytochrome c2 cycA 0.0007
6673 Cytochrome c2 cycA 0.0007
4936 Cytochrome c2 iso-2 Not Available 0.0007
4984 Neuroglobin NGB 0.0007
4998 Hemoglobin-like protein yjbI yjbI 0.0007
5000 HemO hemO 0.0007
4909 CooA protein cooA 0.0007
4910 Cytoglobin CYGB 0.0007
4907 Cytochrome c-L moxG 0.0007
6865 Cytochrome c-L moxG 0.0007
4981 Iron-starvation protein PigA pigA 0.0007
644 Heme oxygenase 2 HMOX2 0.0007
4982 Heme oxygenase 2 pbsA2 0.0007
4942 Diheme cytochrome c napB napB 0.0007
4961 Hemophore HasA hasA 0.0007
4935 Cytochrome c-554 cycA1 0.0007
4971 Nonaheme cytochrome c hmcA 0.0007
4904 Cytochrome c family protein GSU1996 0.0007
4976 Apocytochrome f petA 0.0007
6407 Apocytochrome f petA 0.0007
4999 Cytochrome P450 165B3 CYP165B3 0.0007
4764 Cytochrome P450 165C4 CYP165C4 0.0007
4937 Cytochrome oxidase subunit II rcoxA 0.0007
4960 Putative cytochrome P450-family protein SCO7417 0.0007
4931 Cytochrome P450 167A1 CYP167A1 0.0007
4989 Cytochrome c551 peroxidase ccp 0.0007
5222 Cytochrome c551 peroxidase ccpA 0.0007
4903 Methyl-accepting chemotaxis protein Tar4 0.0007
4922 Cytochrome c, putative SO_4144 0.0007
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0007
4926 Heme-based aerotactic transducer hemAT hemAT 0.0007
4972 P450cin cinA 0.0007
4993 Hydroxylamine oxidoreductase hao1 0.0007
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0007
3093 Catalase HPII katE 0.0007
4952 Catalase/peroxidase katA 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
4920 Peroxidase/catalase katG 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
2119 Cytochrome b5 CYB5A 0.0005
4990 PpcA ppcA 0.0005
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0005
3375 Acidic cytochrome c3 Not Available 0.0005
4988 Sulfite oxidase, mitochondrial SUOX 0.0005
2915 Sensor protein fixL fixL 0.0005
4944 Sensor protein fixL fixL 0.0005
4385 Cytochrome c' Not Available 0.0005
4967 Cytochrome c' cycA 0.0005
5038 Cytochrome c' Not Available 0.0005
5223 Cytochrome c' cycP 0.0005
3570 Cytochrome P450 152A1 cypC 0.0005
4037 Hypothetical protein GPX1 0.0005
4297 Hypothetical protein SP_1951 0.0005
4521 Hypothetical protein BC_2969 0.0005
4540 Hypothetical protein TM_1070 0.0005
4555 Hypothetical protein MT1739 0.0005
4569 Hypothetical protein mshD 0.0005
4578 Hypothetical protein PA3270 0.0005
4747 Hypothetical protein PA3967 0.0005
5177 Hypothetical protein TM_0096 0.0005
5194 Hypothetical protein PA1204 0.0005
5240 Hypothetical protein Rv2991 0.0005
5370 Hypothetical protein TM_1158 0.0005
5710 Hypothetical protein Tb927.5.1360 0.0005
4813 Heme oxygenase hmuO 0.0005
5769 Heme oxygenase Not Available 0.0005
4992 Cytochrome c peroxidase Not Available 0.0005
4289 Cytochrome P450 TT_P0059 0.0005
6262 Cytochrome P450 staP 0.0005
2230 Catalase CAT 0.0005
3249 Catalase katA 0.0005
3625 Catalase katA 0.0005
4539 Catalase katA 0.0005
4941 Catalase katB 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0004
2972 6-deoxyerythronolide B hydroxylase eryF 0.0004
5818 Folate receptor alpha FOLR1 0.0004
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
358 Cystathionine beta-synthase CBS 0.0004
693 Hemoglobin subunit beta HBB 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
2298 Cytochrome P450-cam camC 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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