DT-Web

DB00182 - Amphetamine


Identification
Name Amphetamine
Accession Number DB00182 (APRD00480)
Type small molecule
Description Amphetamine is a chiral compound. The racemic mixture can be divided into its optical antipodes: levo- and dextro-amphetamine. Amphetamine is the parent compound of its own structural class, comprising a broad range of psychoactive derivatives, e.g., MDMA (Ecstasy) and the N-methylated form, methamphetamine. Amphetamine is a homologue of phenethylamine.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 135.2062
Groups illicit
Monoisotopic Weight 135.104799421
Pharmacology
Indication For treatment of Attention Deficit Disorder with Hyperactivity (ADDH) and narcolepsy in children.
Mechanism of action Amphetamines stimulate the release of norepinephrine from central adrenergic receptors. At higher dosages, they cause release of dopamine from the mesocorticolimbic system and the nigrostriatal dopamine systems. Amphetamine may also act as a direct agonist on central 5-HT receptors and may inhibit monoamine oxidase (MAO). In the periphery, amphetamines are believed to cause the release of noradrenaline by acting on the adrenergic nerve terminals and alpha- and beta-receptors. Modulation of serotonergic pathways may contribute to the calming affect. The drug interacts with VMAT enzymes to enhance release of DA and 5-HT from vesicles. It may also directly cause the reversal of DAT and SERT.
Absorption Amphetamine forms easily absorbed molecules that are highly lipid soluble
Protein binding 15-40%
Biotransformation Hepatic
Route of elimination Not Available
Toxicity LD50=180 mg/kg(subcutaneous injection in rat). The most common presenting symptoms seen are agitation, hallucinations, suicidal behaviour, and chest pain.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Chlorpromazine Decreased anorexic effect, may increase psychotic symptoms
Dihydrocodeine Amphetamines may enhance analgesic effects of dihydrocodeine. Monitor for enhanced analgesia. Dose reductions of dihydrocodeine may be appropriate.
Fluoxetine Risk of serotoninergic syndrome
Fluphenazine Decreased anorexic effect, may increase psychotic symptoms
Fluvoxamine Risk of serotoninergic syndrome
Guanethidine Amphetamine may decrease the effect of guanethidine.
Isocarboxazid Possible hypertensive crisis
Mesoridazine Decreased anorexic effect, may increase psychotic symptoms
Methotrimeprazine Decreased anorexic effect, may increase psychotic symptoms
Paroxetine Risk of serotoninergic syndrome
Perphenazine Decreased anorexic effect, may increase psychotic symptoms
Phenelzine Possible hypertensive crisis
Prochlorperazine Decreased anorexic effect, may increase pyschotic symptoms
Promethazine Decreased anorexic effect, may increase pyschotic symptoms
Propericiazine Decreased anorexic effect, may increase pyschotic symptoms
Rasagiline Possible hypertensive crisis
Thioridazine Decreased anorexic effect, may increase psychotic symptoms
Trifluoperazine Decreased anorexic effect, may increase psychotic symptoms
Food Interactions Not Available

Targets


Synaptic vesicular amine transporter
Name Synaptic vesicular amine transporter
Gene Name SLC18A2
Pharmacological action yes
Actions inhibitor
References
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
  • Sulzer D, Chen TK, Lau YY, Kristensen H, Rayport S, Ewing A: Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport. J Neurosci. 1995 May;15(5 Pt 2):4102-8. - Pubmed
DTHybrid score 0.9156
Sodium-dependent dopamine transporter
Name Sodium-dependent dopamine transporter
Gene Name SLC6A3
Pharmacological action yes
Actions negative modulator
References
  • Lott DC, Kim SJ, Cook EH Jr, de Wit H: Dopamine transporter gene associated with diminished subjective response to amphetamine. Neuropsychopharmacology. 2005 Mar;30(3):602-9. - Pubmed
  • Fone KC, Nutt DJ: Stimulants: use and abuse in the treatment of attention deficit hyperactivity disorder. Curr Opin Pharmacol. 2005 Feb;5(1):87-93. - Pubmed
  • Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R, Madras BK: Primate trace amine receptor 1 modulation by the dopamine transporter. J Pharmacol Exp Ther. 2005 Jun;313(3):983-94. Epub 2005 Mar 11. - Pubmed
  • Garcia BG, Wei Y, Moron JA, Lin RZ, Javitch JA, Galli A: Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Mol Pharmacol. 2005 Jul;68(1):102-9. Epub 2005 Mar 28. - Pubmed
  • Madras BK, Miller GM, Fischman AJ: The dopamine transporter and attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005 Jun 1;57(11):1397-409. Epub 2005 Jan 5. - Pubmed
  • Kahlig KM, Binda F, Khoshbouei H, Blakely RD, McMahon DG, Javitch JA, Galli A: Amphetamine induces dopamine efflux through a dopamine transporter channel. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3495-500. Epub 2005 Feb 22. - Pubmed
DTHybrid score 0.6087
Cocaine- and amphetamine-regulated transcript protein
Name Cocaine- and amphetamine-regulated transcript protein
Gene Name CARTPT
Pharmacological action yes
Actions agonist
References
  • Loos RJ, Rankinen T, Tremblay A, Perusse L, Chagnon Y, Bouchard C: Melanocortin-4 receptor gene and physical activity in the Quebec Family Study. Int J Obes (Lond). 2005 Apr;29(4):420-8. - Pubmed
  • McAlister ED, Van Vugt DA: Effect of leptin administration versus re-feeding on hypothalamic neuropeptide gene expression in fasted male rats. Can J Physiol Pharmacol. 2004 Dec;82(12):1128-34. - Pubmed
  • Muhlhausler BS, Adam CL, Marrocco EM, Findlay PA, Roberts CT, McFarlane JR, Kauter KG, McMillen IC: Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation. J Physiol. 2005 May 15;565(Pt 1):185-95. Epub 2005 Jan 20. - Pubmed
  • Scruggs P, Lai CC, Scruggs JE, Dun NJ: Cocaine- and amphetamine-regulated transcript peptide potentiates spinal glutamatergic sympathoexcitation in anesthetized rats. Regul Pept. 2005 Apr 15;127(1-3):79-85. - Pubmed
  • Oliveira VX Jr, Fazio MA, Miranda MT, da Silva JM, Bittencourt JC, Elias CF, Miranda A: Leptin fragments induce Fos immunoreactivity in rat hypothalamus. Regul Pept. 2005 Apr 15;127(1-3):123-32. - Pubmed
  • Vicentic A, Lakatos A, Jones D: The CART receptors: background and recent advances. Peptides. 2006 Aug;27(8):1934-7. Epub 2006 May 19. - Pubmed
DTHybrid score 0.3658
Trace amine-associated receptor 1
Name Trace amine-associated receptor 1
Gene Name TAAR1
Pharmacological action yes
Actions agonist
References
  • Reese EA, Bunzow JR, Arttamangkul S, Sonders MS, Grandy DK: Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. J Pharmacol Exp Ther. 2007 Apr;321(1):178-86. Epub 2007 Jan 11. - Pubmed
  • Xie Z, Westmoreland SV, Bahn ME, Chen GL, Yang H, Vallender EJ, Yao WD, Madras BK, Miller GM: Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. J Pharmacol Exp Ther. 2007 Apr;321(1):116-27. Epub 2007 Jan 18. - Pubmed
  • Wolinsky TD, Swanson CJ, Smith KE, Zhong H, Borowsky B, Seeman P, Branchek T, Gerald CP: The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia. Genes Brain Behav. 2007 Oct;6(7):628-39. Epub 2006 Dec 21. - Pubmed
  • Xie Z, Miller GM: Trace amine-associated receptor 1 is a modulator of the dopamine transporter. J Pharmacol Exp Ther. 2007 Apr;321(1):128-36. Epub 2007 Jan 18. - Pubmed
  • Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R, Madras BK: Primate trace amine receptor 1 modulation by the dopamine transporter. J Pharmacol Exp Ther. 2005 Jun;313(3):983-94. Epub 2005 Mar 11. - Pubmed
DTHybrid score 0.6667

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4677
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3452

Transporters


Solute carrier family 22 member 3
Name Solute carrier family 22 member 3
Gene Name SLC22A3
Actions inhibitor
References
  • Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
DTHybrid score 0.2952
Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Wu X, Prasad PD, Leibach FH, Ganapathy V: cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun. 1998 May 29;246(3):589-95. - Pubmed
  • Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. - Pubmed
DTHybrid score 0.3478

Predictions


Id Partner name Gene Name Score
540 Sodium-dependent noradrenaline transporter SLC6A2 0.2612
4512 Cytochrome P450 3A4 CYP3A4 0.19
824 Sodium-dependent serotonin transporter SLC6A4 0.1764
556 Alpha-1A adrenergic receptor ADRA1A 0.1437
4200 Cytochrome P450 1A2 CYP1A2 0.1262
4757 Cytochrome P450 2C9 CYP2C9 0.1247
6016 Cytochrome P450 2C19 CYP2C19 0.1107
6145 Solute carrier family 22 member 1 SLC22A1 0.105
1588 Multidrug resistance protein 1 ABCB1 0.103
6144 Solute carrier family 22 member 2 SLC22A2 0.1025
3941 Amine oxidase [flavin-containing] A MAOA 0.1014
6030 Cytochrome P450 2B6 CYP2B6 0.0972
3939 Amine oxidase [flavin-containing] B MAOB 0.0941
318 Alpha-2A adrenergic receptor ADRA2A 0.0856
632 Alpha-1B adrenergic receptor ADRA1B 0.0811
4118 Cytochrome P450 3A5 CYP3A5 0.0765
6013 Cytochrome P450 2E1 CYP2E1 0.0759
4924 Cytochrome P450 2C8 CYP2C8 0.0752
833 Organic cation/carnitine transporter 1 SLC22A4 0.0744
492 Histamine H1 receptor HRH1 0.0734
6024 Cytochrome P450 1A1 CYP1A1 0.0604
378 Alpha-2C adrenergic receptor ADRA2C 0.0594
629 Alpha-2B adrenergic receptor ADRA2B 0.0582
6107 Cytochrome P450 3A7 CYP3A7 0.0573
502 5-hydroxytryptamine 2A receptor HTR2A 0.0512
766 Beta-2 adrenergic receptor ADRB2 0.0474
831 D(2) dopamine receptor DRD2 0.0411
1729 Solute carrier family 22 member 6 SLC22A6 0.041
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0404
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0396
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0395
6142 Solute carrier family 22 member 8 SLC22A8 0.0389
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0384
193 Beta-1 adrenergic receptor ADRB1 0.0363
3923 Cholinesterase BCHE 0.036
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0331
590 5-hydroxytryptamine 2C receptor HTR2C 0.0319
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0304
862 Multidrug resistance-associated protein 1 ABCC1 0.03
6106 Cytochrome P450 2C18 CYP2C18 0.0283
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0267
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0266
474 Acetylcholinesterase ACHE 0.0263
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0261
776 Bile salt export pump ABCB11 0.0253
587 Serum albumin ALB 0.0246
341 5-hydroxytryptamine 3 receptor HTR3A 0.0238
436 5-hydroxytryptamine 2B receptor HTR2B 0.023
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0224
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0223
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0215
20 Prostaglandin G/H synthase 1 PTGS1 0.0204
477 DNA topoisomerase 4 subunit A parC 0.0197
886 DNA topoisomerase 4 subunit A parC 0.0197
6226 DNA topoisomerase 4 subunit A parC 0.0197
404 DNA gyrase subunit A gyrA 0.0194
6224 DNA gyrase subunit A gyrA 0.0194
4120 NADPH--cytochrome P450 reductase POR 0.0194
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0192
817 DNA topoisomerase 2-alpha TOP2A 0.0181
1517 Beta-3 adrenergic receptor ADRB3 0.0179
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0176
6014 Cytochrome P450 2A13 CYP2A13 0.0175
320 5-hydroxytryptamine 1A receptor HTR1A 0.0174
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0171
23 D(1A) dopamine receptor DRD1 0.017
1024 Solute carrier family 22 member 11 SLC22A11 0.0169
1898 Cytochrome P450 1B1 CYP1B1 0.0168
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0168
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0167
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0163
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.016
3811 Cytochrome P450 19A1 CYP19A1 0.0159
159 Penicillin-binding protein 2B penA 0.0158
6121 Penicillin-binding protein 2B penA 0.0158
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0151
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0151
1757 Myeloperoxidase MPO 0.015
789 Alpha-1D adrenergic receptor ADRA1D 0.0144
638 D(3) dopamine receptor DRD3 0.0134
465 Calmodulin CALM1 0.0133
6143 Solute carrier family 22 member 7 SLC22A7 0.0128
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0127
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0125
624 Guanidinoacetate N-methyltransferase GAMT 0.0125
847 Mu-type opioid receptor OPRM1 0.0124
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0122
2472 Voltage-gated potassium channel kcsA 0.0121
6366 Voltage-gated potassium channel kcsA 0.0121
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0121
124 Histamine H2 receptor HRH2 0.0119
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0119
380 Cytochrome P450 17A1 CYP17A1 0.0118
2164 Multidrug resistance-associated protein 4 ABCC4 0.0118
432 D(4) dopamine receptor DRD4 0.0118
738 Monocarboxylate transporter 1 SLC16A1 0.0114
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0112
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0112
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0111
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0111
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0111
161 Tubulin beta chain TUBB 0.011
312 Tubulin beta chain TUB2 0.011
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0109
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0109
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0109
5626 Nucleoside diphosphate kinase B NME2 0.0105
164 Histamine H4 receptor HRH4 0.0105
633 Penicillin-binding proteins 1A/1B pbpA 0.0104
163 D(1B) dopamine receptor DRD5 0.0102
6136 Multidrug resistance-associated protein 5 ABCC5 0.0099
1341 Histamine H3 receptor HRH3 0.0099
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
467 Delta-type opioid receptor OPRD1 0.0098
5126 Arginase rocF 0.0096
696 Kappa-type opioid receptor OPRK1 0.0095
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0094
1656 CYP2B protein CYP2B 0.0093
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0092
342 P protein [Includes: DNA-directed DNA polymerase P 0.0091
612 P protein [Includes: DNA-directed DNA polymerase P 0.0091
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
4203 Histamine N-methyltransferase HNMT 0.0088
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0087
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0087
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0086
5294 Nucleoside diphosphate kinase A NME1 0.0084
6070 Nischarin NISCH 0.0083
6031 Cytochrome P450 3A43 CYP3A43 0.0083
1 Peptidoglycan synthetase ftsI ftsI 0.0083
4155 Peptidoglycan synthetase ftsI ftsI 0.0083
175 Thiamin pyrophosphokinase 1 TPK1 0.008
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0079
468 Cytochrome P450 4A11 CYP4A11 0.0079
867 Penicillin-binding protein 3 pbpC 0.0077
6119 Penicillin-binding protein 3 pbp3 0.0077
7154 Penicillin-binding protein 3 pbp3 0.0077
7157 Penicillin-binding protein 3 LMHCC_2184 0.0077
7162 Penicillin-binding protein 3 pbpB 0.0077
7172 Penicillin-binding protein 3 pbp3 0.0077
153 Dopamine beta-hydroxylase DBH 0.0077
3810 Catechol O-methyltransferase COMT 0.0077
737 Mineralocorticoid receptor NR3C2 0.0076
885 5-hydroxytryptamine 1B receptor HTR1B 0.0076
136 Estrogen receptor ESR1 0.0075
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0075
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0074
6102 Arylamine N-acetyltransferase 2 NAT2 0.0073
6137 Multidrug resistance-associated protein 6 ABCC6 0.0073
645 Penicillin-binding protein 1A mrcA 0.0073
5805 Penicillin-binding protein 1A ponA 0.0073
6185 Penicillin-binding protein 1A mrcA 0.0073
6799 Penicillin-binding protein 1A pbpA 0.0073
6432 Transporter snf 0.0071
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0071
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0069
828 Phenylalanine-4-hydroxylase PAH 0.0068
3109 Phenylalanine-4-hydroxylase phhA 0.0068
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0067
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0066
6148 Multidrug resistance-associated protein 7 ABCC10 0.0066
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0065
2230 Catalase CAT 0.0065
3249 Catalase katA 0.0065
3625 Catalase katA 0.0065
4539 Catalase katA 0.0065
4941 Catalase katB 0.0065
2300 Lysozyme E 0.0065
3633 Lysozyme R 0.0065
5597 Lysozyme 17 0.0065
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0065
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0065
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0065
860 Nicotinamide N-methyltransferase NNMT 0.0064
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0064
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
699 Nicotinic acid receptor 1 GPR109A 0.0064
928 Nicotinic acid receptor 2 GPR109B 0.0064
4604 Liver carboxylesterase 1 CES1 0.0064
891 Dihydropteroate synthase folP 0.0063
5359 Dihydropteroate synthase folP 0.0063
7175 Dihydropteroate synthase sulI 0.0063
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0063
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0063
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0063
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0062
6138 Multidrug resistance protein 3 ABCB4 0.0061
6141 Sodium/bile acid cotransporter SLC10A1 0.0061
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0061
725 5-hydroxytryptamine 1D receptor HTR1D 0.006
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
1360 Sphingomyelin phosphodiesterase SMPD1 0.0059
4238 50S ribosomal protein L4 rplD 0.0059
5578 50S ribosomal protein L4 rplD 0.0059
6173 50S ribosomal protein L4 rplD 0.0059
6219 50S ribosomal protein L4 rplD 0.0059
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0058
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0058
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0058
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0058
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0057
788 Creatine kinase M-type CKM 0.0057
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0056
4237 50S ribosomal protein L22 rplV 0.0054
537 ATP synthase delta chain, mitochondrial ATP5D 0.0054
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0054
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0054
769 High-affinity choline transporter 1 SLC5A7 0.0054
3927 Choline transporter-like protein 3 SLC44A3 0.0054
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0054
861 Choline kinase alpha CHKA 0.0054
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0054
1686 Choline transporter-like protein 1 SLC44A1 0.0054
3926 Choline transporter-like protein 2 SLC44A2 0.0054
700 Choline dehydrogenase, mitochondrial CHDH 0.0054
3925 Choline transporter-like protein 4 SLC44A4 0.0054
576 Choline O-acetyltransferase CHAT 0.0054
3922 Phospholipase D2 PLD2 0.0054
3924 Phospholipase D1 PLD1 0.0054
844 Epidermal growth factor receptor EGFR 0.0054
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0053
5682 Ribonuclease pancreatic RNASE1 0.0053
871 Glucocorticoid receptor NR3C1 0.0052
731 HIV-1 protease HIV-1 protease 0.0052
94 5-hydroxytryptamine 4 receptor HTR4 0.0052
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0052
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0051
482 Glycine receptor subunit alpha-1 GLRA1 0.0051
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.005
716 5-hydroxytryptamine 7 receptor HTR7 0.005
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0049
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0047
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0046
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0046
29 Tubulin beta-1 chain TUBB1 0.0046
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0046
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0046
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0045
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0045
251 Alcohol dehydrogenase 1A ADH1A 0.0045
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0044
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0044
232 Corticosteroid-binding globulin SERPINA6 0.0044
2112 Toll-like receptor 9 TLR9 0.0044
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0044
705 Glutamate receptor 1 GRIA1 0.0044
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0043
3947 Xanthine dehydrogenase/oxidase XDH 0.0043
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0042
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0042
2539 Tubulin alpha-1 chain TUBA4A 0.0042
528 5-hydroxytryptamine 1E receptor HTR1E 0.0042
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0042
260 Cytochrome P450 51 ERG11 0.0041
761 Cytochrome P450 51 ERG11 0.0041
3163 Cytochrome P450 51 cyp51 0.0041
518 Peroxidase/catalase T katG 0.0041
444 Alcohol dehydrogenase 1B ADH1B 0.004
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.004
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.004
7 Nitric oxide synthase, inducible NOS2 0.004
500 Monocarboxylate transporter 4 SLC16A3 0.004
290 Prostaglandin G/H synthase 2 PTGS2 0.0039
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0039
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0039
563 Thyroid peroxidase TPO 0.0038
614 Progesterone receptor PGR 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
869 Estrogen receptor beta ESR2 0.0038
3932 Glutathione S-transferase A2 GSTA2 0.0038
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0037
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0036
6146 High affinity copper uptake protein 1 SLC31A1 0.0036
4773 Deoxycytidine kinase DCK 0.0036
517 Alcohol dehydrogenase 1C ADH1C 0.0035
702 UMP-CMP kinase CMPK1 0.0034
1192 Sulfotransferase 1A1 SULT1A1 0.0034
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0034
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0033
6506 Stathmin-4 STMN4 0.0033
6182 Cytochrome P450 2J2 CYP2J2 0.0033
173 Toll-like receptor 7 TLR7 0.0033
756 Sex hormone-binding globulin SHBG 0.0033
1256 5-hydroxytryptamine 6 receptor HTR6 0.0033
499 Arginine decarboxylase ADC 0.0033
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
976 Platelet glycoprotein IX GP9 0.0032
6163 Copper-transporting ATPase 2 ATP7B 0.0032
6165 Copper-transporting ATPase 1 ATP7A 0.0032
2298 Cytochrome P450-cam camC 0.0031
106 Cannabinoid receptor 2 CNR2 0.0031
6168 Solute carrier family 22 member 16 SLC22A16 0.0031
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
6174 50S ribosomal protein L32 rpmF 0.0031
577 Argininosuccinate lyase ASL 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
146 Androgen receptor AR 0.003
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
1039 Histone deacetylase 9 HDAC9 0.003
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
291 Nitric-oxide synthase, endothelial NOS3 0.003
84 Nuclear receptor 0B1 NR0B1 0.003
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0029
68 Cannabinoid receptor 1 CNR1 0.0029
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0029
908 Glutathione S-transferase theta-1 GSTT1 0.0029
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0028
565 Extracellular calcium-sensing receptor CASR 0.0028
1050 Bile salt sulfotransferase SULT2A1 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
373 Transthyretin TTR 0.0028
904 Glutathione S-transferase P GSTP1 0.0028
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0028
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
558 Solute carrier family 12 member 1 SLC12A1 0.0027
275 Arachidonate 5-lipoxygenase ALOX5 0.0027
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0027
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0026
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0026
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0026
896 Glutathione S-transferase Mu 1 GSTM1 0.0025
1010 Cytochrome P450 51A1 CYP51A1 0.0025
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0024
511 5-hydroxytryptamine 1F receptor HTR1F 0.0024
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0024
357 Carbonic anhydrase 2 CA2 0.0024
6151 Monocarboxylate transporter 10 SLC16A10 0.0024
3917 Methylenetetrahydrofolate reductase MTHFR 0.0024
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0024
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0024
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0024
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0023
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0023
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0022
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
921 Glutamate receptor 2 GRIA2 0.0021
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0021
751 Potassium channel subfamily K member 6 KCNK6 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.002
5756 D-alanyl-D-alanine carboxypeptidase dac 0.002
174 Sigma 1-type opioid receptor SIGMAR1 0.002
400 Coagulation factor IX F9 0.002
5461 Coagulation factor IX F9 0.002
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.002
365 Dihydrofolate reductase DHFR 0.002
2381 Dihydrofolate reductase DFR1 0.002
2833 Dihydrofolate reductase Not Available 0.002
2931 Dihydrofolate reductase folA 0.002
3544 Dihydrofolate reductase folA 0.002
3682 Dihydrofolate reductase folA 0.002
6642 Dihydrofolate reductase folA 0.002
6756 Dihydrofolate reductase dfrA 0.002
3809 Estrogen-related receptor gamma ESRRG 0.002
4226 Uridine phosphorylase 2 UPP2 0.0019
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0019
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
172 Potassium channel subfamily K member 1 KCNK1 0.0019
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0019
1275 Estrogen sulfotransferase SULT1E1 0.0019
295 Carbonic anhydrase 1 CA1 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0018
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0018
1268 Neuropeptide S receptor NPSR1 0.0018
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0018
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0018
604 Vitamin K-dependent protein Z PROZ 0.0018
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0018
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0018
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0018
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0018
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0018
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1178 Adenosine A2a receptor ADORA2A 0.0018
4225 Uridine phosphorylase 1 UPP1 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
6085 Fatty acid-binding protein, intestinal FABP2 0.0018
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
5934 Cytochrome P450 26A1 CYP26A1 0.0017
6218 Pannexin-1 PANX1 0.0017
719 Retinoic acid receptor responder protein 1 RARRES1 0.0017
770 Retinoic acid-induced protein 3 GPRC5A 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0017
413 Amidophosphoribosyltransferase PPAT 0.0017
2515 Amidophosphoribosyltransferase purF 0.0017
3714 Amidophosphoribosyltransferase purF 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0016
6073 Potassium channel subfamily K member 9 KCNK9 0.0016
6072 Potassium channel subfamily K member 3 KCNK3 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6220 Aryl hydrocarbon receptor AHR 0.0016
3937 Fatty-acid amide hydrolase FAAH 0.0016
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0016
1629 Transcription factor AP-1 JUN 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
2320 Thymidine kinase, cytosolic TK1 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
569 Retinal dehydrogenase 2 ALDH1A2 0.0015
3086 Plasmepsin-2 Not Available 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
611 Retinal dehydrogenase 1 ALDH1A1 0.0014
469 Annexin A1 ANXA1 0.0014
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
798 Osteocalcin BGLAP 0.0014
3639 Thymidine phosphorylase deoA 0.0014
3936 Thymidine phosphorylase TYMP 0.0014
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0013
811 Translocator protein TSPO 0.0013
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0013
3404 Exotoxin A eta 0.0013
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0013
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0013
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0013
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0013
2207 Rhodopsin RHO 0.0012
369 Coagulation factor VII F7 0.0012
780 Retinoic acid receptor RXR-gamma RXRG 0.0012
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
228 Beta platelet-derived growth factor receptor PDGFRB 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0011
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0011
24 Thymidylate synthase TMP1 0.0011
359 Thymidylate synthase TYMS 0.0011
2626 Thymidylate synthase thyA 0.0011
2729 Thymidylate synthase thyA 0.0011
5352 Thymidylate synthase THYA 0.0011
88 Retinoic acid receptor RXR-beta RXRB 0.0011
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0011
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0011
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0011
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0011
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0011
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
162 Retinoic acid receptor gamma-1 RARG 0.0011
489 Monocarboxylate transporter 2 SLC16A7 0.0011
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0011
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0011
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0011
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.001
6020 Aldehyde oxidase AOX1 0.001
407 Vascular endothelial growth factor receptor 2 KDR 0.001
4311 tRNA TRDMT1 0.001
4325 tRNA trmD 0.001
4328 tRNA trmD 0.001
284 DNA-directed RNA polymerase beta chain rpoB 0.001
5773 DNA-directed RNA polymerase beta chain rpoB 0.001
144 Hemoglobin subunit alpha HBA1 0.001
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.001
734 D1 dopamine receptor-interacting protein calcyon CALY 0.001
777 Tumor necrosis factor TNF 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
239 Coagulation factor X F10 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
26 Vascular endothelial growth factor receptor 3 FLT4 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
4122 Histone deacetylase 2 HDAC2 0.0009
16 Adenosine A1 receptor ADORA1 0.0009
32 Vascular endothelial growth factor receptor 1 FLT1 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
1262 Corticotropin-lipotropin POMC 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
165 FL cytokine receptor FLT3 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
6126 Carbonic anhydrase 7 CA7 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0008
70 Type-1 angiotensin II receptor AGTR1 0.0008
54 Prothrombin F2 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
122 P2Y purinoceptor 12 P2RY12 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
1992 Vitamin D-binding protein GC 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
1618 High affinity nerve growth factor receptor NTRK1 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
592 Carbonic anhydrase 4 CA4 0.0006
4103 Proteasome subunit beta type 2 PSMB2 0.0006
4102 Proteasome subunit beta type 5 PSMB5 0.0006
4101 Proteasome subunit beta type 1 PSMB1 0.0006
1630 Integrin beta-2 ITGB2 0.0006
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
2449 Tubulin alpha-3 chain TUBA1A 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
856 Vitamin D3 receptor VDR 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
572 Integrin alpha-L ITGAL 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
760 Fibroblast growth factor 1 FGF1 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0004
823 Fibroblast growth factor receptor 2 FGFR2 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
3957 Adenosine deaminase ADA 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0003
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0002
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