DT-Web

DB00831 - Trifluoperazine


Identification
Name Trifluoperazine
Accession Number DB00831 (APRD00173, DB08616)
Type small molecule
Description A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 407.496
Groups approved
Monoisotopic Weight 407.164303088
Pharmacology
Indication For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation.
Mechanism of action Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Absorption Not Available
Protein binding Not Available
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amphetamine Decreased anorexic effect, may increase psychotic symptoms
Benzphetamine Antipsychotics may diminish the stimulatory effect of Amphetamines. Monitor effectiveness of amphetamine therapy when altering concurrent antipsychotic therapy as antipsychotic agents may impair the stimulatory effect of amphetamines.
Bromocriptine The phenothiazine decreases the effect of bromocriptine
Cisapride Increased risk of cardiotoxicity and arrhythmias
Dexfenfluramine Decreased anorexic effect, may increase psychotic symptoms
Dextroamphetamine Decreased anorexic effect, may increase psychotic symptoms
Diethylpropion Decreased anorexic effect, may increase psychotic symptoms
Donepezil Possible antagonism of action
Fenfluramine Decreased anorexic effect, may increase psychotic symptoms
Galantamine Possible antagonism of action
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Guanethidine Trifluoperazine may decrease the effect of guanethidine.
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Mazindol Decreased anorexic effect, may increase psychotic symptoms
Methamphetamine Decreased anorexic effect, may increase psychotic symptoms
Metrizamide Increased risk of convulsions
Phendimetrazine Decreased anorexic effect, may increase psychotic symptoms
Phenmetrazine Decreased anorexic effect, may increase psychotic symptoms
Phentermine Decreased anorexic effect, may increase psychotic symptoms
Phenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms
Rivastigmine Possible antagonism of action
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Trifluoperazine, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Tetrabenazine May cause dopamine deficiency. Monitor for Tetrabenazine adverse effects.
Thiabendazole The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Trifluoperazine by decreasing Trifluoperazine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Trifluoperazine if Thiabendazole is initiated, discontinued or dose changed.
Trimethobenzamide Trimethobenzamide and Trifluoperazine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine The antihistamine, Triprolidine, may increase the arrhythmogenic effect of the phenothiazine, Trifluoperazine. Monitor for symptoms of ventricular arrhythmias. Additive anticholinergic and CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium Trospium and Trifluoperazine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Food Interactions Not Available

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. - Pubmed
  • Lahti RA, Evans DL, Stratman NC, Figur LM: Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications. Eur J Pharmacol. 1993 Jun 4;236(3):483-6. - Pubmed
  • Schmidt MH, Lee T: Investigation of striatal dopamine D2 receptor acquisition following prenatal neuroleptic exposure. Psychiatry Res. 1991 Mar;36(3):319-28. - Pubmed
  • Cahir M, King DJ: Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat. Eur Neuropsychopharmacol. 2005 Mar;15(2):231-4. - Pubmed
  • Seeman P, Lee T, Chau-Wong M, Wong K: Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature. 1976 Jun 24;261(5562):717-9. - Pubmed
DTHybrid score 0.4083
D1 dopamine receptor-interacting protein calcyon
Name D1 dopamine receptor-interacting protein calcyon
Gene Name CALY
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Seeman P, Lee T, Chau-Wong M, Wong K: Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature. 1976 Jun 24;261(5562):717-9. - Pubmed
  • Madrid PB, Polgar WE, Toll L, Tanga MJ: Synthesis and antitubercular activity of phenothiazines with reduced binding to dopamine and serotonin receptors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3014-7. Epub 2007 Mar 24. - Pubmed
DTHybrid score 0.2693
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Fujinaga M, Hoffman BB, Baden JM: Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos. Dev Biol. 1994 Apr;162(2):558-67. - Pubmed
  • Huerta-Bahena J, Villalobos-Molina R, Garcia-Sainz JA: Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983 Jan;23(1):67-70. - Pubmed
DTHybrid score 0.4332
Calmodulin
Name Calmodulin
Gene Name CALM1
Pharmacological action unknown
Actions inhibitor
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
  • Torres-Piedra M, Figueroa M, Hernandez-Abreu O, Ibarra-Barajas M, Navarrete-Vazquez G, Estrada-Soto S: Vasorelaxant effect of flavonoids through calmodulin inhibition: Ex vivo, in vitro, and in silico approaches. Bioorg Med Chem. 2011 Jan 1;19(1):542-6. Epub 2010 Nov 4. - Pubmed
DTHybrid score 0.5865
Troponin C, slow skeletal and cardiac muscles
Name Troponin C, slow skeletal and cardiac muscles
Gene Name TNNC1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
  • Kleerekoper Q, Liu W, Choi D, Putkey JA: Identification of binding sites for bepridil and trifluoperazine on cardiac troponin C. J Biol Chem. 1998 Apr 3;273(14):8153-60. - Pubmed
DTHybrid score 0.6288
Protein S100-A4
Name Protein S100-A4
Gene Name S100A4
Pharmacological action unknown
Actions inhibitor
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
  • Malashkevich VN, Dulyaninova NG, Ramagopal UA, Liriano MA, Varney KM, Knight D, Brenowitz M, Weber DJ, Almo SC, Bresnick AR: Phenothiazines inhibit S100A4 function by inducing protein oligomerization. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8605-10. Epub 2010 Apr 26. - Pubmed
DTHybrid score 0.3241

Enzymes


Xanthine dehydrogenase/oxidase
Name Xanthine dehydrogenase/oxidase
Gene Name XDH
Actions conversion inhibitor
References
  • -
  • Hirata Y, Ishii K, Taguchi T, Suita S, Takeshige K: Conversion of xanthine dehydrogenase to xanthine oxidase during ischemia of the rat small intestine and the effect of trifluoperazine on the conversion. J Pediatr Surg. 1993 Apr;28(4):597-600. - Pubmed
  • Greene EL, Paller MS: Calcium and free radicals in hypoxia/reoxygenation injury of renal epithelial cells. Am J Physiol. 1994 Jan;266(1 Pt 2):F13-20. - Pubmed
DTHybrid score 0.518
UDP-glucuronosyltransferase 1-4
Name UDP-glucuronosyltransferase 1-4
Gene Name UGT1A4
Actions substrate
References
  • -
  • Kerdpin O, Mackenzie PI, Bowalgaha K, Finel M, Miners JO: Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10. Drug Metab Dispos. 2009 Sep;37(9):1948-55. Epub 2009 Jun 1. - Pubmed
  • Fujiwara R, Nakajima M, Yamanaka H, Katoh M, Yokoi T: Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities. Drug Metab Dispos. 2007 Oct;35(10):1781-7. Epub 2007 Jul 9. - Pubmed
  • Uchaipichat V, Mackenzie PI, Elliot DJ, Miners JO: Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone) - probes
DTHybrid score 0.2811
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3835

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed
DTHybrid score 0.4007

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2501
4119 Cytochrome P450 2D6 CYP2D6 0.2278
23 D(1A) dopamine receptor DRD1 0.158
502 5-hydroxytryptamine 2A receptor HTR2A 0.1539
318 Alpha-2A adrenergic receptor ADRA2A 0.1471
4757 Cytochrome P450 2C9 CYP2C9 0.1212
632 Alpha-1B adrenergic receptor ADRA1B 0.1211
722 Troponin I, cardiac muscle TNNI3 0.1178
6016 Cytochrome P450 2C19 CYP2C19 0.1108
4118 Cytochrome P450 3A5 CYP3A5 0.0984
638 D(3) dopamine receptor DRD3 0.0961
320 5-hydroxytryptamine 1A receptor HTR1A 0.0943
6013 Cytochrome P450 2E1 CYP2E1 0.0899
6030 Cytochrome P450 2B6 CYP2B6 0.0898
4924 Cytochrome P450 2C8 CYP2C8 0.0894
6024 Cytochrome P450 1A1 CYP1A1 0.0831
629 Alpha-2B adrenergic receptor ADRA2B 0.083
590 5-hydroxytryptamine 2C receptor HTR2C 0.0823
432 D(4) dopamine receptor DRD4 0.0822
378 Alpha-2C adrenergic receptor ADRA2C 0.0786
492 Histamine H1 receptor HRH1 0.0745
6107 Cytochrome P450 3A7 CYP3A7 0.073
789 Alpha-1D adrenergic receptor ADRA1D 0.0689
885 5-hydroxytryptamine 1B receptor HTR1B 0.0635
725 5-hydroxytryptamine 1D receptor HTR1D 0.062
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0612
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0599
163 D(1B) dopamine receptor DRD5 0.058
1089 Cartilage oligomeric matrix protein COMP 0.0571
1108 Calpastatin CAST 0.0571
1898 Cytochrome P450 1B1 CYP1B1 0.0571
4246 Voltage-dependent anion-selective channel protein 2 VDAC2 0.0564
4247 Voltage-dependent anion-selective channel protein 3 VDAC3 0.0564
5718 Cytochrome P450 2A6 CYP2A6 0.0563
4245 Voltage-dependent anion-selective channel protein 1 VDAC1 0.0563
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0561
6048 Troponin C, skeletal muscle TNNC2 0.0559
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0539
6145 Solute carrier family 22 member 1 SLC22A1 0.0529
436 5-hydroxytryptamine 2B receptor HTR2B 0.0494
3923 Cholinesterase BCHE 0.0479
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0477
587 Serum albumin ALB 0.0476
1181 Alpha-1-acid glycoprotein 1 ORM1 0.046
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0456
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0444
766 Beta-2 adrenergic receptor ADRB2 0.0444
716 5-hydroxytryptamine 7 receptor HTR7 0.0442
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0435
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0434
193 Beta-1 adrenergic receptor ADRB1 0.0424
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0423
617 Muscarinic acetylcholine receptor M2 CHRM2 0.042
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0405
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0403
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0402
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0385
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0383
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0382
824 Sodium-dependent serotonin transporter SLC6A4 0.0376
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0359
6020 Aldehyde oxidase AOX1 0.0359
1507 Cytochrome c CYCS 0.0356
1256 5-hydroxytryptamine 6 receptor HTR6 0.0354
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0341
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0331
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0329
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0329
2132 Protein S100-B S100B 0.0329
6144 Solute carrier family 22 member 2 SLC22A2 0.0326
131 Synaptic vesicular amine transporter SLC18A2 0.0314
3811 Cytochrome P450 19A1 CYP19A1 0.0309
6142 Solute carrier family 22 member 8 SLC22A8 0.0304
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.03
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0292
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.029
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0276
3941 Amine oxidase [flavin-containing] A MAOA 0.0274
290 Prostaglandin G/H synthase 2 PTGS2 0.0265
856 Vitamin D3 receptor VDR 0.0264
20 Prostaglandin G/H synthase 1 PTGS1 0.0261
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0259
36 Insulin receptor INSR 0.0258
776 Bile salt export pump ABCB11 0.0252
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0251
862 Multidrug resistance-associated protein 1 ABCC1 0.0251
713 Sodium-dependent dopamine transporter SLC6A3 0.0242
6143 Solute carrier family 22 member 7 SLC22A7 0.0239
6106 Cytochrome P450 2C18 CYP2C18 0.0233
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0224
341 5-hydroxytryptamine 3 receptor HTR3A 0.022
528 5-hydroxytryptamine 1E receptor HTR1E 0.0218
118 Organic cation/carnitine transporter 2 SLC22A5 0.0217
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0217
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0216
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0214
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0211
817 DNA topoisomerase 2-alpha TOP2A 0.0207
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0207
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0204
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0192
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0191
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0191
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0188
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0185
1729 Solute carrier family 22 member 6 SLC22A6 0.0184
6147 Solute carrier family 22 member 3 SLC22A3 0.0179
136 Estrogen receptor ESR1 0.0177
833 Organic cation/carnitine transporter 1 SLC22A4 0.0173
1405 Thiopurine S-methyltransferase TPMT 0.0172
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0171
896 Glutathione S-transferase Mu 1 GSTM1 0.017
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.017
164 Histamine H4 receptor HRH4 0.0169
63 Malate dehydrogenase mdh 0.0165
2329 Malate dehydrogenase mdh 0.0165
3445 Malate dehydrogenase mdh 0.0165
4420 Malate dehydrogenase mdh 0.0165
4438 Malate dehydrogenase mdh 0.0165
124 Histamine H2 receptor HRH2 0.0164
477 DNA topoisomerase 4 subunit A parC 0.0163
886 DNA topoisomerase 4 subunit A parC 0.0163
6226 DNA topoisomerase 4 subunit A parC 0.0163
1656 CYP2B protein CYP2B 0.0161
1757 Myeloperoxidase MPO 0.0161
404 DNA gyrase subunit A gyrA 0.016
6224 DNA gyrase subunit A gyrA 0.016
3876 Aromatic-L-amino-acid decarboxylase DDC 0.016
3939 Amine oxidase [flavin-containing] B MAOB 0.016
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0158
327 Glutathione reductase gor 0.0156
5110 Glutathione reductase GR2 0.0156
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0153
3823 Cytokine receptor common gamma chain IL2RG 0.0151
893 [Citrate [pro-3S]-lyase] ligase citC 0.0149
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0149
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0147
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
6102 Arylamine N-acetyltransferase 2 NAT2 0.0142
4120 NADPH--cytochrome P450 reductase POR 0.0139
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0139
4604 Liver carboxylesterase 1 CES1 0.0137
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0132
6137 Multidrug resistance-associated protein 6 ABCC6 0.0132
724 Interleukin-2 receptor alpha chain IL2RA 0.0131
717 Interleukin-2 receptor subunit beta IL2RB 0.0131
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.013
737 Mineralocorticoid receptor NR3C2 0.0126
2164 Multidrug resistance-associated protein 4 ABCC4 0.0124
2314 Triosephosphate isomerase TPI 0.0123
3417 Triosephosphate isomerase tpiA 0.0123
3443 Triosephosphate isomerase tpiA 0.0123
6346 Triosephosphate isomerase TPI1 0.0123
1192 Sulfotransferase 1A1 SULT1A1 0.0121
871 Glucocorticoid receptor NR3C1 0.0119
6136 Multidrug resistance-associated protein 5 ABCC5 0.0119
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0118
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0118
2795 Methionine aminopeptidase 2 METAP2 0.0117
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0115
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0115
6148 Multidrug resistance-associated protein 7 ABCC10 0.0114
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0112
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0112
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0112
303 Diamine acetyltransferase 2 SAT2 0.0109
623 Spermine oxidase SMOX 0.0109
1317 Spermine synthase SMS 0.0109
3932 Glutathione S-transferase A2 GSTA2 0.0109
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0105
474 Acetylcholinesterase ACHE 0.0105
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0104
5682 Ribonuclease pancreatic RNASE1 0.0104
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0103
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0103
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0102
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.01
869 Estrogen receptor beta ESR2 0.01
4031 Glutathione S-transferase A1 GSTA1 0.01
847 Mu-type opioid receptor OPRM1 0.01
467 Delta-type opioid receptor OPRD1 0.01
123 Diamine acetyltransferase 1 SAT1 0.01
696 Kappa-type opioid receptor OPRK1 0.0098
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
6146 High affinity copper uptake protein 1 SLC31A1 0.0095
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0095
571 Melatonin receptor type 1A MTNR1A 0.0094
362 Melatonin receptor type 1B MTNR1B 0.0094
908 Glutathione S-transferase theta-1 GSTT1 0.0093
6163 Copper-transporting ATPase 2 ATP7B 0.0093
6165 Copper-transporting ATPase 1 ATP7A 0.0093
904 Glutathione S-transferase P GSTP1 0.0089
6168 Solute carrier family 22 member 16 SLC22A16 0.0088
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0086
723 Cytosolic phospholipase A2 PLA2G4A 0.0084
1374 Natriuretic peptides B NPPB 0.0084
1827 Gap junction alpha-1 protein GJA1 0.0084
1908 Vascular cell adhesion protein 1 VCAM1 0.0084
468 Cytochrome P450 4A11 CYP4A11 0.0082
380 Cytochrome P450 17A1 CYP17A1 0.0081
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.008
449 Ornithine decarboxylase ODC1 0.0078
6171 Solute carrier family 28 member 3 SLC28A3 0.0077
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0077
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0077
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0076
923 Glutamate receptor 3 GRIA3 0.0074
1262 Corticotropin-lipotropin POMC 0.0073
267 Plasminogen activator inhibitor 1 SERPINE1 0.0073
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0072
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0071
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0071
731 HIV-1 protease HIV-1 protease 0.0071
1039 Histone deacetylase 9 HDAC9 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
1517 Beta-3 adrenergic receptor ADRB3 0.0071
777 Tumor necrosis factor TNF 0.0071
16 Adenosine A1 receptor ADORA1 0.0071
6138 Multidrug resistance protein 3 ABCB4 0.0071
6221 Steroid hormone receptor ERR1 ESRRA 0.0068
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0068
1178 Adenosine A2a receptor ADORA2A 0.0067
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0066
94 5-hydroxytryptamine 4 receptor HTR4 0.0066
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0065
183 Vascular endothelial growth factor A VEGFA 0.0064
260 Cytochrome P450 51 ERG11 0.0064
761 Cytochrome P450 51 ERG11 0.0064
3163 Cytochrome P450 51 cyp51 0.0064
2616 Ganglioside GM2 activator GM2A 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
921 Glutamate receptor 2 GRIA2 0.0063
844 Epidermal growth factor receptor EGFR 0.0063
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0063
705 Glutamate receptor 1 GRIA1 0.0062
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0062
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0062
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0062
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0062
3809 Estrogen-related receptor gamma ESRRG 0.0062
738 Monocarboxylate transporter 1 SLC16A1 0.0062
6182 Cytochrome P450 2J2 CYP2J2 0.0062
482 Glycine receptor subunit alpha-1 GLRA1 0.0062
3830 Calreticulin CALR 0.0062
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0061
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0061
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0061
427 Substance-P receptor TACR1 0.006
4192 DNA topoisomerase 2-beta TOP2B 0.006
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.006
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0059
537 ATP synthase delta chain, mitochondrial ATP5D 0.0059
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0058
6035 Nuclear receptor ROR-beta RORB 0.0058
6034 Hydroxyindole O-methyltransferase ASMT 0.0058
6036 Eosinophil peroxidase EPX 0.0058
400 Coagulation factor IX F9 0.0058
5461 Coagulation factor IX F9 0.0058
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0058
828 Phenylalanine-4-hydroxylase PAH 0.0057
3109 Phenylalanine-4-hydroxylase phhA 0.0057
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0057
818 50S ribosomal protein L10 rplJ 0.0057
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0056
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0056
122 P2Y purinoceptor 12 P2RY12 0.0054
504 Mast/stem cell growth factor receptor KIT 0.0054
551 Carnitine O-acetyltransferase CRAT 0.0054
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0054
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0054
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0054
174 Sigma 1-type opioid receptor SIGMAR1 0.0053
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0053
714 Glutathione reductase, mitochondrial GSR 0.0053
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0053
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0053
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0053
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0053
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0053
604 Vitamin K-dependent protein Z PROZ 0.0053
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0053
239 Coagulation factor X F10 0.0053
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0052
511 5-hydroxytryptamine 1F receptor HTR1F 0.0052
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0052
694 Matrix protein 2 M 0.0051
26 Vascular endothelial growth factor receptor 3 FLT4 0.0051
765 Indoleamine 2,3-dioxygenase IDO1 0.0051
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0051
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
6141 Sodium/bile acid cotransporter SLC10A1 0.0049
32 Vascular endothelial growth factor receptor 1 FLT1 0.0049
6220 Aryl hydrocarbon receptor AHR 0.0049
2449 Tubulin alpha-3 chain TUBA1A 0.0049
422 Vitamin K-dependent protein C PROC 0.0049
1245 Vitamin K-dependent protein S PROS1 0.0049
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0048
273 Apoptosis regulator Bcl-2 BCL2 0.0048
2499 Tubulin beta-2C chain TUBB2C 0.0046
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0046
228 Beta platelet-derived growth factor receptor PDGFRB 0.0046
6432 Transporter snf 0.0045
614 Progesterone receptor PGR 0.0044
1024 Solute carrier family 22 member 11 SLC22A11 0.0044
70 Type-1 angiotensin II receptor AGTR1 0.0043
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0043
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0043
756 Sex hormone-binding globulin SHBG 0.0043
407 Vascular endothelial growth factor receptor 2 KDR 0.0043
4238 50S ribosomal protein L4 rplD 0.004
5578 50S ribosomal protein L4 rplD 0.004
6173 50S ribosomal protein L4 rplD 0.004
6219 50S ribosomal protein L4 rplD 0.004
3917 Methylenetetrahydrofolate reductase MTHFR 0.004
798 Osteocalcin BGLAP 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
1636 Trace amine-associated receptor 1 TAAR1 0.0039
161 Tubulin beta chain TUBB 0.0039
312 Tubulin beta chain TUB2 0.0039
373 Transthyretin TTR 0.0039
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0038
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0038
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0038
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0038
117 Sterol O-acyltransferase 1 SOAT1 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0038
4122 Histone deacetylase 2 HDAC2 0.0038
4237 50S ribosomal protein L22 rplV 0.0037
6014 Cytochrome P450 2A13 CYP2A13 0.0037
992 Protein tyrosine kinase 2 beta PTK2B 0.0037
3426 Glutamine synthetase glnA 0.0037
3987 Glutamine synthetase GLUL 0.0037
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0037
952 Dipeptidyl peptidase 4 DPP4 0.0037
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0036
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0036
6085 Fatty acid-binding protein, intestinal FABP2 0.0036
369 Coagulation factor VII F7 0.0036
6151 Monocarboxylate transporter 10 SLC16A10 0.0036
5998 Toll-like receptor 8 TLR8 0.0035
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0035
6755 Poliovirus receptor PVR 0.0034
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0034
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0034
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0034
6044 Serum paraoxonase/lactonase 3 PON3 0.0033
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0033
146 Androgen receptor AR 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0032
3957 Adenosine deaminase ADA 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
54 Prothrombin F2 0.0031
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0031
4103 Proteasome subunit beta type 2 PSMB2 0.0031
4102 Proteasome subunit beta type 5 PSMB5 0.0031
4101 Proteasome subunit beta type 1 PSMB1 0.0031
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.003
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.003
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.003
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.003
173 Toll-like receptor 7 TLR7 0.003
6031 Cytochrome P450 3A43 CYP3A43 0.003
768 FK506-binding protein 1A FKBP1A 0.0029
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0029
1010 Cytochrome P450 51A1 CYP51A1 0.0029
683 Potassium transporter GK0582 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0028
76 Nitric-oxide synthase, brain NOS1 0.0028
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0027
2297 Genome polyprotein Not Available 0.0027
2322 Genome polyprotein Not Available 0.0027
2694 Genome polyprotein Not Available 0.0027
2719 Genome polyprotein Not Available 0.0027
2860 Genome polyprotein Not Available 0.0027
2928 Genome polyprotein Not Available 0.0027
3160 Genome polyprotein Not Available 0.0027
3260 Genome polyprotein Not Available 0.0027
4783 Genome polyprotein Not Available 0.0027
5726 Genome polyprotein Not Available 0.0027
5779 Genome polyprotein Not Available 0.0027
5867 Genome polyprotein Not Available 0.0027
6253 Genome polyprotein Not Available 0.0027
6301 Genome polyprotein Not Available 0.0027
6380 Genome polyprotein Not Available 0.0027
6381 Genome polyprotein Not Available 0.0027
6437 Genome polyprotein Not Available 0.0027
6520 Genome polyprotein Not Available 0.0027
6521 Genome polyprotein Not Available 0.0027
6652 Genome polyprotein Not Available 0.0027
6734 Genome polyprotein Not Available 0.0027
6735 Genome polyprotein Not Available 0.0027
6736 Genome polyprotein Not Available 0.0027
6737 Genome polyprotein Not Available 0.0027
6738 Genome polyprotein Not Available 0.0027
6739 Genome polyprotein Not Available 0.0027
6744 Genome polyprotein Not Available 0.0027
6748 Genome polyprotein Not Available 0.0027
6894 Genome polyprotein Not Available 0.0027
6898 Genome polyprotein Not Available 0.0027
3810 Catechol O-methyltransferase COMT 0.0027
1618 High affinity nerve growth factor receptor NTRK1 0.0027
7 Nitric oxide synthase, inducible NOS2 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
4210 Toll-like receptor 4 TLR4 0.0026
1629 Transcription factor AP-1 JUN 0.0026
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
6228 Nuclear receptor coactivator 1 NCOA1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
365 Dihydrofolate reductase DHFR 0.0025
2381 Dihydrofolate reductase DFR1 0.0025
2833 Dihydrofolate reductase Not Available 0.0025
2931 Dihydrofolate reductase folA 0.0025
3544 Dihydrofolate reductase folA 0.0025
3682 Dihydrofolate reductase folA 0.0025
6642 Dihydrofolate reductase folA 0.0025
6756 Dihydrofolate reductase dfrA 0.0025
24 Thymidylate synthase TMP1 0.0025
359 Thymidylate synthase TYMS 0.0025
2626 Thymidylate synthase thyA 0.0025
2729 Thymidylate synthase thyA 0.0025
5352 Thymidylate synthase THYA 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0024
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
291 Nitric-oxide synthase, endothelial NOS3 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
6070 Nischarin NISCH 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0023
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0022
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0022
284 DNA-directed RNA polymerase beta chain rpoB 0.0022
5773 DNA-directed RNA polymerase beta chain rpoB 0.0022
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0022
394 Calcineurin subunit B isoform 1 PPP3R1 0.0022
6742 Recoverin RCVRN 0.0022
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
2528 Fatty acid metabolism regulator protein fadR 0.0022
6740 Fatty acid metabolism regulator protein fadR 0.0022
6753 Apolipoprotein M APOM 0.0022
6747 Chalcone/stilbene synthase family protein MT1417 0.0022
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0022
6743 Non-fluorescent flavoprotein luxF 0.0022
6751 Gag polyprotein gag 0.0022
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0022
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0022
6749 Polyprotein Not Available 0.0022
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0022
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
33 Cystine/glutamate transporter SLC7A11 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
6167 Organic solute transporter subunit beta OSTB 0.0021
6166 Organic solute transporter subunit alpha OSTA 0.0021
1360 Sphingomyelin phosphodiesterase SMPD1 0.0021
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0021
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.002
3856 Fibroblast growth factor receptor 3 FGFR3 0.002
1820 Beta-nerve growth factor NGF 0.002
153 Dopamine beta-hydroxylase DBH 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
5961 Insulin INS 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
275 Arachidonate 5-lipoxygenase ALOX5 0.0019
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
6527 Lymphocyte antigen 96 LY96 0.0019
165 FL cytokine receptor FLT3 0.0019
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0019
6149 Solute carrier family 22 member 10 SLC22A10 0.0019
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0019
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0019
6316 ADP-ribosylation factor 1 ARF1 0.0019
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0018
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0018
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0018
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
823 Fibroblast growth factor receptor 2 FGFR2 0.0018
1714 Mitogen-activated protein kinase 3 MAPK3 0.0018
6750 ADP-ribosylation factor 6 ARF6 0.0018
811 Translocator protein TSPO 0.0018
6524 Protein tonB tonB 0.0018
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0018
229 Retinoic acid receptor beta RARB 0.0017
780 Retinoic acid receptor RXR-gamma RXRG 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
1648 Elastin ELN 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0017
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0016
1830 5'-nucleotidase NT5E 0.0016
4311 tRNA TRDMT1 0.0016
4325 tRNA trmD 0.0016
4328 tRNA trmD 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
6824 Tyrosine-protein kinase Lyn LYN 0.0016
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0016
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0016
1243 Cathepsin D CTSD 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0016
88 Retinoic acid receptor RXR-beta RXRB 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0016
936 Ephrin type-A receptor 2 EPHA2 0.0015
162 Retinoic acid receptor gamma-1 RARG 0.0015
702 UMP-CMP kinase CMPK1 0.0015
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0015
6043 Putative G-protein coupled receptor 44 GPR44 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0014
864 Gag-Pol polyprotein gag-pol 0.0014
2237 Gag-Pol polyprotein gag-pol 0.0014
2326 Gag-Pol polyprotein gag-pol 0.0014
2451 Gag-Pol polyprotein gag-pol 0.0014
2901 Gag-Pol polyprotein gag-pol 0.0014
3165 Gag-Pol polyprotein gag-pol 0.0014
3722 Gag-Pol polyprotein gag-pol 0.0014
6306 Gag-Pol polyprotein gag-pol 0.0014
6624 Gag-Pol polyprotein gag-pol 0.0014
976 Platelet glycoprotein IX GP9 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
484 Tyrosine-protein kinase ABL2 ABL2 0.0014
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0014
1063 Signal transducer and activator of transcription 5B STAT5B 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0014
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0014
444 Alcohol dehydrogenase 1B ADH1B 0.0014
814 Ryanodine receptor 1 RYR1 0.0013
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
4486 Phenol 2-hydroxylase component B pheA2 0.0013
4439 Ferredoxin reductase bphA4 0.0013
4477 Dihydrolipoyl dehydrogenase lpdV 0.0013
5077 Dihydrolipoyl dehydrogenase Not Available 0.0013
5117 Dihydrolipoyl dehydrogenase lpd 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0013
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
4773 Deoxycytidine kinase DCK 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2427 Ferrichrome-iron receptor fhuA 0.0012
5078 Amine oxidase, flavin-containing PSPTO1126 0.0012
5122 Mersacidin decarboxylase mrsD 0.0012
526 Thioredoxin reductase trxB 0.0012
3767 Thioredoxin reductase trxB 0.0012
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0012
3763 5,10-methylenetetrahydrofolate reductase metF 0.0012
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0012
5094 5,10-methylenetetrahydrofolate reductase metF 0.0012
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0012
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0012
5115 FkbI fkbI 0.0012
3133 UDP-galactopyranose mutase glf 0.0012
5099 UDP-galactopyranose mutase glf 0.0012
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0012
5095 Putidaredoxin reductase camA 0.0012
5083 Cryptochrome DASH cry 0.0012
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0012
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0012
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0012
5081 L-aspartate oxidase nadB 0.0012
5111 Phenylacetone monooxygenase pamO 0.0012
1410 Oxidoreductase HSD17B6 0.0012
4725 Oxidoreductase Not Available 0.0012
5124 Oxidoreductase Not Available 0.0012
5109 Outer membrane protein p64k or PM-6 m-6 0.0012
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0012
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0012
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0012
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
518 Peroxidase/catalase T katG 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0011
251 Alcohol dehydrogenase 1A ADH1A 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
469 Annexin A1 ANXA1 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
3102 Flavohemoprotein hmp 0.0011
4969 Flavohemoprotein hmp 0.0011
563 Thyroid peroxidase TPO 0.0011
4440 NADH peroxidase npr 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
517 Alcohol dehydrogenase 1C ADH1C 0.0011
5072 N,N-dimethylglycine oxidase dmg 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
5073 Ferredoxin--NADP reductase petH 0.0011
5076 Ferredoxin--NADP reductase fpr 0.0011
5119 Ferredoxin--NADP reductase petH 0.0011
5121 Ferredoxin--NADP reductase fpr 0.0011
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0011
3594 Deoxyribodipyrimidine photo-lyase phr 0.0011
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0011
5080 Deoxyribodipyrimidine photo-lyase phr 0.0011
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0011
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0011
2526 NADPH-ferredoxin reductase fprA fprA 0.0011
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0011
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0011
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0011
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0011
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0011
2470 Pyruvate oxidase pox5 0.0011
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0011
822 Aldose reductase AKR1B1 0.0011
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.001
2268 Cholesterol oxidase choB 0.001
2822 Cholesterol oxidase choA 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
144 Hemoglobin subunit alpha HBA1 0.001
1864 RET proto-oncogene RET 0.001
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.001
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.001
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
126 D-lactate dehydrogenase dld 0.001
3545 D-lactate dehydrogenase Not Available 0.001
4510 D-lactate dehydrogenase ldhA 0.001
4203 Histamine N-methyltransferase HNMT 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
760 Fibroblast growth factor 1 FGF1 0.001
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.001
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.001
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.001
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.001
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.001
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.001
68 Cannabinoid receptor 1 CNR1 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.001
2893 Glycine oxidase thiO 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0009
5934 Cytochrome P450 26A1 CYP26A1 0.0009
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0009
2567 Thymidylate synthase thyX thyX 0.0009
751 Potassium channel subfamily K member 6 KCNK6 0.0009
2823 Trypanothione reductase TPR 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2769 P-hydroxybenzoate hydroxylase pobA 0.0009
2809 P-hydroxybenzoate hydroxylase pobA 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0009
2981 Phospholipase A2, membrane associated PLA2G2A 0.0009
172 Potassium channel subfamily K member 1 KCNK1 0.0008
5787 Angiopoietin-1 receptor TEK 0.0008
2380 Monomeric sarcosine oxidase soxA 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6645 D-amino-acid oxidase DAO 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
4226 Uridine phosphorylase 2 UPP2 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
816 Biliverdin reductase A BLVRA 0.0007
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0007
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0007
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0007
295 Carbonic anhydrase 1 CA1 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
1630 Integrin beta-2 ITGB2 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
6677 Myelin P2 protein PMP2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0006
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0006
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0006
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0006
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0006
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0006
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0006
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0006
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0006
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0006
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0006
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0006
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0006
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0006
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0006
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0006
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0006
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0006
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0006
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0006
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0006
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0006
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0006
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0006
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0006
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0006
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0006
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0006
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0006
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0006
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0006
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0006
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0006
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0006
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0006
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0006
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0006
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0006
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0006
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0006
729 GDP-L-fucose synthetase TSTA3 0.0006
3463 GDP-L-fucose synthetase fcl 0.0006
167 L-lactate dehydrogenase C chain LDHC 0.0006
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0006
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0006
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0006
3726 D-3-phosphoglycerate dehydrogenase serA 0.0006
4291 D-3-phosphoglycerate dehydrogenase serA 0.0006
206 3-keto-steroid reductase HSD17B7 0.0006
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0006
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0006
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0006
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0006
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0006
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0006
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0006
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0006
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0006
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0006
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0006
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0006
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0006
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0006
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0006
34 7-dehydrocholesterol reductase DHCR7 0.0006
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0006
711 UDP-glucose 6-dehydrogenase UGDH 0.0006
3672 UDP-glucose 6-dehydrogenase hasB 0.0006
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0006
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0006
107 C-4 methylsterol oxidase SC4MOL 0.0006
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0006
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0006
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0006
643 Peroxisomal bifunctional enzyme EHHADH 0.0006
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
646 Malate dehydrogenase, cytoplasmic MDH1 0.0006
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0006
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0006
328 Sorbitol dehydrogenase SORD 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
396 Alcohol dehydrogenase 4 ADH4 0.0006
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0006
597 Dihydropteridine reductase QDPR 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0006
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0006
666 NADP-dependent malic enzyme ME1 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
857 Malate dehydrogenase, mitochondrial MDH2 0.0005
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0005
77 L-lactate dehydrogenase B chain LDHB 0.0005
12 Alcohol dehydrogenase class 3 ADH5 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0005
6026 Alcohol dehydrogenase 6 ADH6 0.0005
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0005
2021 Thrombomodulin THBD 0.0005
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0005
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0005
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
626 Cysteine dioxygenase type 1 CDO1 0.0005
627 11-cis retinol dehydrogenase RDH5 0.0005
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0005
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0005
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
473 L-lactate dehydrogenase A chain LDHA 0.0005
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0005
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0005
569 Retinal dehydrogenase 2 ALDH1A2 0.0005
2207 Rhodopsin RHO 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0005
572 Integrin alpha-L ITGAL 0.0005
13 Aminomethyltransferase, mitochondrial AMT 0.0005
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
611 Retinal dehydrogenase 1 ALDH1A1 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0005
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0005
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0005
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
279 Tyrosinase TYR 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
654 Flavin reductase BLVRB 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
6218 Pannexin-1 PANX1 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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