DT-Web

DB00850 - Perphenazine


Identification
Name Perphenazine
Accession Number DB00850 (APRD00429)
Type small molecule
Description An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 403.969
Groups approved
Monoisotopic Weight 403.148510866
Pharmacology
Indication For use in the management of the manifestations of psychotic disorders and for the control of severe nausea and vomiting in adults.
Mechanism of action Binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre. Perphenazine also binds the alpha andrenergic receptor. This receptor's action is mediated by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Absorption Absolute bioavailability is 40% following oral administration.
Protein binding Not Available
Biotransformation Hepatic.
Route of elimination Perphenazine is extensively metabolized in the liver to a number of metabolites by sulfoxidation, hydroxylation, dealkylation, and glucuronidation.
Toxicity Symptoms of overdose include stupor or coma, and children may have convulsive seizures. Signs of arousal may not occur for 48 hours. Oral LD50=318 mg/kg (rat); IPR LD50=64 mg/kg (mouse)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amphetamine Decreased anorexic effect, may increase psychotic symptoms
Atomoxetine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Benzphetamine Antipsychotics may diminish the stimulatory effect of Amphetamines. Monitor effectiveness of amphetamine therapy when altering concurrent antipsychotic therapy as antipsychotic agents may impair the stimulatory effect of amphetamines.
Bromocriptine The phenothiazine decreases the effect of bromocriptine
Cisapride Increased risk of cardiotoxicity and arrhythmias
Dexfenfluramine Decreased anorexic effect, may increase psychotic symptoms
Dextroamphetamine Decreased anorexic effect, may increase psychotic symptoms
Diethylpropion Decreased anorexic effect, may increase psychotic symptoms
Donepezil Possible antagonism of action
Fenfluramine Decreased anorexic effect, may increase psychotic symptoms
Galantamine Possible antagonism of action
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Guanethidine Perphenazine may decrease the effect of guanethidine.
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Mazindol Decreased anorexic effect, may increase psychotic symptoms
Methamphetamine Decreased anorexic effect, may increase psychotic symptoms
Metrizamide Increased risk of convulsions
Phendimetrazine Decreased anorexic effect, may increase psychotic symptoms
Phenmetrazine Decreased anorexic effect, may increase psychotic symptoms
Phentermine Decreased anorexic effect, may increase psychotic symptoms
Phenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms
Rivastigmine Possible antagonism of action
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Perphenazine, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents.
Terbinafine Terbinafine may reduce the metabolism and clearance of Perphenazine. Consider alternate therapy or monitor for therapeutic/adverse effects of Perphenazine if Terbinafine is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Tetrabenazine May cause dopamine deficiency. Monitor for Tetrabenazine adverse effects.
Trimethobenzamide Trimethobenzamide and Perphenazine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine The antihistamine, Triprolidine, may increase the arrhythmogenic effect of the phenothiazine, Perphenazine. Monitor for symptoms of ventricular arrhythmias. Additive anticholinergic and CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium Trospium and Perphenazine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Food Interactions
  • Take with food.
  • Avoid alcohol.
  • Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. - Pubmed
  • Hoyberg OJ, Fensbo C, Remvig J, Lingjaerde O, Sloth-Nielsen M, Salvesen I: Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations. Acta Psychiatr Scand. 1993 Dec;88(6):395-402. - Pubmed
  • Qin ZH, Weiss B: Dopamine receptor blockade increases dopamine D2 receptor and glutamic acid decarboxylase mRNAs in mouse substantia nigra. Eur J Pharmacol. 1994 Sep 15;269(1):25-33. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Talvik M, Nordstrom AL, Larsen NE, Jucaite A, Cervenka S, Halldin C, Farde L: A cross-validation study on the relationship between central D2 receptor occupancy and serum perphenazine concentration. Psychopharmacology (Berl). 2004 Sep;175(2):148-53. Epub 2004 Mar 6. - Pubmed
  • Farde L, Wiesel FA, Nordstrom AL, Sedvall G: D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics. Psychopharmacology (Berl). 1989;99 Suppl:S28-31. - Pubmed
DTHybrid score 0.3904
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action yes
Actions antagonist
References
  • Dolzan V, Plesnicar BK, Serretti A, Mandelli L, Zalar B, Koprivsek J, Breskvar K: Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment. Am J Med Genet B Neuropsychiatr Genet. 2007 Sep 5;144(6):809-15. - Pubmed
  • Farde L, Wiesel FA, Nordstrom AL, Sedvall G: D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics. Psychopharmacology (Berl). 1989;99 Suppl:S28-31. - Pubmed
DTHybrid score 0.3027
Calmodulin
Name Calmodulin
Gene Name CALM1
Pharmacological action unknown
Actions inhibitor
References
  • Mongin AA, Cai Z, Kimelberg HK: Volume-dependent taurine release from cultured astrocytes requires permissive [Ca(2+)](i) and calmodulin. Am J Physiol. 1999 Oct;277(4 Pt 1):C823-32. - Pubmed
  • Kawai M, Nakashima A, Ueno M, Ushimaru T, Aiba K, Doi H, Uritani M: Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature. Curr Genet. 2001 May;39(3):166-74. - Pubmed
  • Edlind T, Smith L, Henry K, Katiyar S, Nickels J: Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling. Mol Microbiol. 2002 Oct;46(1):257-68. - Pubmed
  • Natochin YuV, Shakhmatova EI, Bakos P: Water and sodium transport: effects of calcium channel blocker and calmodulin antagonists on the apical and basolateral membranes of amphibian epithelia. Gen Physiol Biophys. 1987 Feb;6(1):35-44. - Pubmed
DTHybrid score 0.4172

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Otani K, Aoshima T: Pharmacogenetics of classical and new antipsychotic drugs. Ther Drug Monit. 2000 Feb;22(1):118-21. - Pubmed
  • Micallef J, Fakra E, Blin O: [Use of antidepressant drugs in schizophrenic patients with depression] Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9. - Pubmed
  • Linnet K, Wiborg O: Steady-state serum concentrations of the neuroleptic perphenazine in relation to CYP2D6 genetic polymorphism. Clin Pharmacol Ther. 1996 Jul;60(1):41-7. - Pubmed
  • Ozdemir V, Naranjo CA, Herrmann N, Reed K, Sellers EM, Kalow W: Paroxetine potentiates the central nervous system side effects of perphenazine: contribution of cytochrome P4502D6 inhibition in vivo. Clin Pharmacol Ther. 1997 Sep;62(3):334-47. - Pubmed
  • Hamelin BA, Bouayad A, Drolet B, Gravel A, Turgeon J: In vitro characterization of cytochrome P450 2D6 inhibition by classic histamine H1 receptor antagonists. Drug Metab Dispos. 1998 Jun;26(6):536-9. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6471
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5434
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3983
Cytochrome P450 2C18
Name Cytochrome P450 2C18
Gene Name CYP2C18
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2324
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5344
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.434
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6088
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7614

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.3227
4118 Cytochrome P450 3A5 CYP3A5 0.2605
6013 Cytochrome P450 2E1 CYP2E1 0.2232
6107 Cytochrome P450 3A7 CYP3A7 0.2001
502 5-hydroxytryptamine 2A receptor HTR2A 0.1964
6024 Cytochrome P450 1A1 CYP1A1 0.1572
5718 Cytochrome P450 2A6 CYP2A6 0.1549
556 Alpha-1A adrenergic receptor ADRA1A 0.1421
587 Serum albumin ALB 0.135
492 Histamine H1 receptor HRH1 0.1256
20 Prostaglandin G/H synthase 1 PTGS1 0.1233
318 Alpha-2A adrenergic receptor ADRA2A 0.1114
320 5-hydroxytryptamine 1A receptor HTR1A 0.1083
638 D(3) dopamine receptor DRD3 0.1052
590 5-hydroxytryptamine 2C receptor HTR2C 0.1002
432 D(4) dopamine receptor DRD4 0.0943
824 Sodium-dependent serotonin transporter SLC6A4 0.0938
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0928
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0923
632 Alpha-1B adrenergic receptor ADRA1B 0.0888
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0856
163 D(1B) dopamine receptor DRD5 0.0856
1181 Alpha-1-acid glycoprotein 1 ORM1 0.083
6145 Solute carrier family 22 member 1 SLC22A1 0.0809
629 Alpha-2B adrenergic receptor ADRA2B 0.0752
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0715
378 Alpha-2C adrenergic receptor ADRA2C 0.0692
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0657
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0625
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0623
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0617
290 Prostaglandin G/H synthase 2 PTGS2 0.0602
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0584
1729 Solute carrier family 22 member 6 SLC22A6 0.058
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0568
3811 Cytochrome P450 19A1 CYP19A1 0.0562
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.056
885 5-hydroxytryptamine 1B receptor HTR1B 0.0558
725 5-hydroxytryptamine 1D receptor HTR1D 0.0557
1898 Cytochrome P450 1B1 CYP1B1 0.0549
436 5-hydroxytryptamine 2B receptor HTR2B 0.0549
6144 Solute carrier family 22 member 2 SLC22A2 0.0545
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0536
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0525
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0516
862 Multidrug resistance-associated protein 1 ABCC1 0.0508
713 Sodium-dependent dopamine transporter SLC6A3 0.0482
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0481
3923 Cholinesterase BCHE 0.0478
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0468
3941 Amine oxidase [flavin-containing] A MAOA 0.046
766 Beta-2 adrenergic receptor ADRB2 0.0457
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0449
118 Organic cation/carnitine transporter 2 SLC22A5 0.0435
789 Alpha-1D adrenergic receptor ADRA1D 0.0431
847 Mu-type opioid receptor OPRM1 0.0431
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0408
716 5-hydroxytryptamine 7 receptor HTR7 0.0406
193 Beta-1 adrenergic receptor ADRB1 0.0396
341 5-hydroxytryptamine 3 receptor HTR3A 0.0395
468 Cytochrome P450 4A11 CYP4A11 0.0391
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0385
467 Delta-type opioid receptor OPRD1 0.0384
136 Estrogen receptor ESR1 0.0382
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0372
1507 Cytochrome c CYCS 0.0368
731 HIV-1 protease HIV-1 protease 0.0357
776 Bile salt export pump ABCB11 0.0353
696 Kappa-type opioid receptor OPRK1 0.0352
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0347
722 Troponin I, cardiac muscle TNNI3 0.0347
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0346
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.034
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0335
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0334
6142 Solute carrier family 22 member 8 SLC22A8 0.0331
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0326
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0314
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.031
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0307
3939 Amine oxidase [flavin-containing] B MAOB 0.0307
2164 Multidrug resistance-associated protein 4 ABCC4 0.0306
6147 Solute carrier family 22 member 3 SLC22A3 0.0305
260 Cytochrome P450 51 ERG11 0.0296
761 Cytochrome P450 51 ERG11 0.0296
3163 Cytochrome P450 51 cyp51 0.0296
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0294
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.028
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0274
871 Glucocorticoid receptor NR3C1 0.0271
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0265
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0262
36 Insulin receptor INSR 0.0258
6031 Cytochrome P450 3A43 CYP3A43 0.0257
122 P2Y purinoceptor 12 P2RY12 0.0257
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0256
1256 5-hydroxytryptamine 6 receptor HTR6 0.0254
6143 Solute carrier family 22 member 7 SLC22A7 0.0254
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0253
833 Organic cation/carnitine transporter 1 SLC22A4 0.0242
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0239
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0235
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0234
817 DNA topoisomerase 2-alpha TOP2A 0.0229
380 Cytochrome P450 17A1 CYP17A1 0.0218
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0217
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0216
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0216
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0215
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0213
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0213
891 Dihydropteroate synthase folP 0.0212
5359 Dihydropteroate synthase folP 0.0212
7175 Dihydropteroate synthase sulI 0.0212
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0208
146 Androgen receptor AR 0.0206
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0201
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.02
734 D1 dopamine receptor-interacting protein calcyon CALY 0.02
6182 Cytochrome P450 2J2 CYP2J2 0.0193
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0192
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0192
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0189
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0183
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0182
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0181
6048 Troponin C, skeletal muscle TNNC2 0.0181
1757 Myeloperoxidase MPO 0.0181
238 Peroxisome proliferator-activated receptor gamma PPARG 0.018
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0176
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0176
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0175
94 5-hydroxytryptamine 4 receptor HTR4 0.0172
70 Type-1 angiotensin II receptor AGTR1 0.017
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0168
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0168
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0168
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0168
124 Histamine H2 receptor HRH2 0.0168
1089 Cartilage oligomeric matrix protein COMP 0.0168
1108 Calpastatin CAST 0.0168
528 5-hydroxytryptamine 1E receptor HTR1E 0.0166
1024 Solute carrier family 22 member 11 SLC22A11 0.0166
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0165
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0165
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0165
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0165
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0165
571 Melatonin receptor type 1A MTNR1A 0.0165
362 Melatonin receptor type 1B MTNR1B 0.0164
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0164
844 Epidermal growth factor receptor EGFR 0.0164
174 Sigma 1-type opioid receptor SIGMAR1 0.0163
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0163
482 Glycine receptor subunit alpha-1 GLRA1 0.0163
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0163
6220 Aryl hydrocarbon receptor AHR 0.0161
6102 Arylamine N-acetyltransferase 2 NAT2 0.0161
3947 Xanthine dehydrogenase/oxidase XDH 0.016
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0159
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0159
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0158
921 Glutamate receptor 2 GRIA2 0.0156
85 Growth hormone receptor GHR 0.0156
504 Mast/stem cell growth factor receptor KIT 0.0156
474 Acetylcholinesterase ACHE 0.0154
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0154
811 Translocator protein TSPO 0.0153
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0152
6859 Protein S100-A4 S100A4 0.0149
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0148
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0148
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
477 DNA topoisomerase 4 subunit A parC 0.0146
886 DNA topoisomerase 4 subunit A parC 0.0146
6226 DNA topoisomerase 4 subunit A parC 0.0146
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0145
427 Substance-P receptor TACR1 0.0145
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0143
4120 NADPH--cytochrome P450 reductase POR 0.0143
131 Synaptic vesicular amine transporter SLC18A2 0.0141
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.014
6136 Multidrug resistance-associated protein 5 ABCC5 0.0139
705 Glutamate receptor 1 GRIA1 0.0138
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0138
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0138
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0136
777 Tumor necrosis factor TNF 0.0135
3426 Glutamine synthetase glnA 0.0135
3987 Glutamine synthetase GLUL 0.0135
818 50S ribosomal protein L10 rplJ 0.0134
4604 Liver carboxylesterase 1 CES1 0.0131
6148 Multidrug resistance-associated protein 7 ABCC10 0.013
537 ATP synthase delta chain, mitochondrial ATP5D 0.013
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0127
6137 Multidrug resistance-associated protein 6 ABCC6 0.0127
1656 CYP2B protein CYP2B 0.0125
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0125
614 Progesterone receptor PGR 0.0124
2314 Triosephosphate isomerase TPI 0.0123
3417 Triosephosphate isomerase tpiA 0.0123
3443 Triosephosphate isomerase tpiA 0.0123
6346 Triosephosphate isomerase TPI1 0.0123
6014 Cytochrome P450 2A13 CYP2A13 0.0123
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0123
407 Vascular endothelial growth factor receptor 2 KDR 0.0122
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0122
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0121
1010 Cytochrome P450 51A1 CYP51A1 0.012
869 Estrogen receptor beta ESR2 0.012
2795 Methionine aminopeptidase 2 METAP2 0.0117
365 Dihydrofolate reductase DHFR 0.0115
2381 Dihydrofolate reductase DFR1 0.0115
2833 Dihydrofolate reductase Not Available 0.0115
2931 Dihydrofolate reductase folA 0.0115
3544 Dihydrofolate reductase folA 0.0115
3682 Dihydrofolate reductase folA 0.0115
6642 Dihydrofolate reductase folA 0.0115
6756 Dihydrofolate reductase dfrA 0.0115
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0115
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0114
26 Vascular endothelial growth factor receptor 3 FLT4 0.0114
373 Transthyretin TTR 0.0114
756 Sex hormone-binding globulin SHBG 0.0113
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0112
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0112
161 Tubulin beta chain TUBB 0.0111
312 Tubulin beta chain TUB2 0.0111
6141 Sodium/bile acid cotransporter SLC10A1 0.0111
16 Adenosine A1 receptor ADORA1 0.011
32 Vascular endothelial growth factor receptor 1 FLT1 0.0109
6174 50S ribosomal protein L32 rpmF 0.0108
1262 Corticotropin-lipotropin POMC 0.0108
1178 Adenosine A2a receptor ADORA2A 0.0105
2132 Protein S100-B S100B 0.0105
275 Arachidonate 5-lipoxygenase ALOX5 0.0104
5682 Ribonuclease pancreatic RNASE1 0.0104
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0104
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0104
228 Beta platelet-derived growth factor receptor PDGFRB 0.0103
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
3810 Catechol O-methyltransferase COMT 0.0101
6432 Transporter snf 0.01
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.01
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.01
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0099
6085 Fatty acid-binding protein, intestinal FABP2 0.0099
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0099
4116 Dihydropteroate synthetase Not Available 0.0097
295 Carbonic anhydrase 1 CA1 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
952 Dipeptidyl peptidase 4 DPP4 0.0096
29 Tubulin beta-1 chain TUBB1 0.0096
737 Mineralocorticoid receptor NR3C2 0.0096
49 Endothelin B receptor EDNRB 0.0096
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0095
88 Retinoic acid receptor RXR-beta RXRB 0.0095
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0094
232 Corticosteroid-binding globulin SERPINA6 0.0093
578 Endothelin-1 receptor EDNRA 0.009
6020 Aldehyde oxidase AOX1 0.009
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0088
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0087
3808 Dihydropteroate synthase 2 folP2 0.0085
3601 Dihydropteroate synthase 1 folP1 0.0085
3807 Dihydropteroate synthase 1 folP1 0.0085
4122 Histone deacetylase 2 HDAC2 0.0084
738 Monocarboxylate transporter 1 SLC16A1 0.0084
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0083
84 Nuclear receptor 0B1 NR0B1 0.0082
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0082
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0082
780 Retinoic acid receptor RXR-gamma RXRG 0.0082
565 Extracellular calcium-sensing receptor CASR 0.008
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0079
173 Toll-like receptor 7 TLR7 0.0079
3830 Calreticulin CALR 0.0078
153 Dopamine beta-hydroxylase DBH 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
518 Peroxidase/catalase T katG 0.0077
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0075
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0074
1541 Metalloproteinase mmp20 0.0074
923 Glutamate receptor 3 GRIA3 0.0074
6035 Nuclear receptor ROR-beta RORB 0.0074
6034 Hydroxyindole O-methyltransferase ASMT 0.0074
6036 Eosinophil peroxidase EPX 0.0073
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0073
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
357 Carbonic anhydrase 2 CA2 0.0072
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0071
856 Vitamin D3 receptor VDR 0.0071
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0071
4203 Histamine N-methyltransferase HNMT 0.0071
162 Retinoic acid receptor gamma-1 RARG 0.007
1618 High affinity nerve growth factor receptor NTRK1 0.007
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0069
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0069
1629 Transcription factor AP-1 JUN 0.0068
2112 Toll-like receptor 9 TLR9 0.0068
563 Thyroid peroxidase TPO 0.0067
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0067
284 DNA-directed RNA polymerase beta chain rpoB 0.0067
5773 DNA-directed RNA polymerase beta chain rpoB 0.0067
183 Vascular endothelial growth factor A VEGFA 0.0067
823 Fibroblast growth factor receptor 2 FGFR2 0.0067
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0066
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0066
581 Cytochrome P450 2R1 CYP2R1 0.0065
273 Apoptosis regulator Bcl-2 BCL2 0.0065
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0065
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0065
765 Indoleamine 2,3-dioxygenase IDO1 0.0064
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0064
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0064
1648 Elastin ELN 0.0063
719 Retinoic acid receptor responder protein 1 RARRES1 0.0063
770 Retinoic acid-induced protein 3 GPRC5A 0.0063
1050 Bile salt sulfotransferase SULT2A1 0.0063
133 Dihydropterate synthase sulI 0.0063
3937 Fatty-acid amide hydrolase FAAH 0.0062
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0062
814 Ryanodine receptor 1 RYR1 0.0062
511 5-hydroxytryptamine 1F receptor HTR1F 0.0061
564 Cellular retinoic acid-binding protein 1 CRABP1 0.006
3932 Glutathione S-transferase A2 GSTA2 0.006
6126 Carbonic anhydrase 7 CA7 0.006
24 Thymidylate synthase TMP1 0.0059
359 Thymidylate synthase TYMS 0.0059
2626 Thymidylate synthase thyA 0.0059
2729 Thymidylate synthase thyA 0.0059
5352 Thymidylate synthase THYA 0.0059
1039 Histone deacetylase 9 HDAC9 0.0059
634 Squalene monooxygenase SQLE 0.0059
7196 Squalene monooxygenase ERG1 0.0059
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0059
164 Histamine H4 receptor HRH4 0.0058
6138 Multidrug resistance protein 3 ABCB4 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
4311 tRNA TRDMT1 0.0058
4325 tRNA trmD 0.0058
4328 tRNA trmD 0.0058
5880 Thrombopoietin receptor MPL 0.0058
208 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0058
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0057
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0057
1192 Sulfotransferase 1A1 SULT1A1 0.0057
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0057
2539 Tubulin alpha-1 chain TUBA4A 0.0057
6044 Serum paraoxonase/lactonase 3 PON3 0.0057
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0057
6146 High affinity copper uptake protein 1 SLC31A1 0.0056
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0056
1517 Beta-3 adrenergic receptor ADRB3 0.0055
1275 Estrogen sulfotransferase SULT1E1 0.0055
569 Retinal dehydrogenase 2 ALDH1A2 0.0055
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0055
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0055
6506 Stathmin-4 STMN4 0.0055
5300 Antigen peptide transporter 1 TAP1 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
2981 Phospholipase A2, membrane associated PLA2G2A 0.0054
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0052
1992 Vitamin D-binding protein GC 0.0052
712 Tubulin alpha chain TUB1 0.0052
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
611 Retinal dehydrogenase 1 ALDH1A1 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0051
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0051
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0051
319 Opioid receptor, sigma 1 OPRS1 0.0051
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0051
1360 Sphingomyelin phosphodiesterase SMPD1 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
904 Glutathione S-transferase P GSTP1 0.005
165 FL cytokine receptor FLT3 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.005
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.005
6043 Putative G-protein coupled receptor 44 GPR44 0.0049
1630 Integrin beta-2 ITGB2 0.0048
6151 Monocarboxylate transporter 10 SLC16A10 0.0048
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0048
7 Nitric oxide synthase, inducible NOS2 0.0047
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0045
3086 Plasmepsin-2 Not Available 0.0045
3856 Fibroblast growth factor receptor 3 FGFR3 0.0045
239 Coagulation factor X F10 0.0045
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0045
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0044
1196 Complement decay-accelerating factor CD55 0.0044
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
5787 Angiopoietin-1 receptor TEK 0.0044
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0043
976 Platelet glycoprotein IX GP9 0.0043
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0043
1483 Membrane copper amine oxidase AOC3 0.0043
4103 Proteasome subunit beta type 2 PSMB2 0.0043
4102 Proteasome subunit beta type 5 PSMB5 0.0043
4101 Proteasome subunit beta type 1 PSMB1 0.0043
3809 Estrogen-related receptor gamma ESRRG 0.0043
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0042
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0042
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0041
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0041
469 Annexin A1 ANXA1 0.0041
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0041
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
54 Prothrombin F2 0.004
694 Matrix protein 2 M 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
2808 Chloramphenicol acetyltransferase 3 cat3 0.0038
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0038
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0038
3957 Adenosine deaminase ADA 0.0038
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0038
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
5934 Cytochrome P450 26A1 CYP26A1 0.0037
768 FK506-binding protein 1A FKBP1A 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0037
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0036
251 Alcohol dehydrogenase 1A ADH1A 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
4210 Toll-like receptor 4 TLR4 0.0035
2417 Chloramphenicol acetyltransferase cat 0.0035
3278 Chloramphenicol acetyltransferase cat 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
2810 Dr hemagglutinin structural subunit draA 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
936 Ephrin type-A receptor 2 EPHA2 0.0034
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
820 Glycine receptor subunit alpha-2 GLRA2 0.0034
33 Cystine/glutamate transporter SLC7A11 0.0033
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0033
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
229 Retinoic acid receptor beta RARB 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0032
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0032
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0032
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0032
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0032
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0032
5798 Mitogen-activated protein kinase 11 MAPK11 0.0032
444 Alcohol dehydrogenase 1B ADH1B 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
267 Plasminogen activator inhibitor 1 SERPINE1 0.0031
751 Potassium channel subfamily K member 6 KCNK6 0.0031
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3639 Thymidine phosphorylase deoA 0.003
3936 Thymidine phosphorylase TYMP 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
106 Cannabinoid receptor 2 CNR2 0.003
6149 Solute carrier family 22 member 10 SLC22A10 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
908 Glutathione S-transferase theta-1 GSTT1 0.003
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
291 Nitric-oxide synthase, endothelial NOS3 0.0029
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
172 Potassium channel subfamily K member 1 KCNK1 0.0029
6221 Steroid hormone receptor ERR1 ESRRA 0.0028
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0028
4217 Telomerase reverse transcriptase TERT 0.0028
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
517 Alcohol dehydrogenase 1C ADH1C 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
572 Integrin alpha-L ITGAL 0.0027
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0027
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0026
3913 Glutamic acid decarboxylase GAD65 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
1374 Natriuretic peptides B NPPB 0.0025
1827 Gap junction alpha-1 protein GJA1 0.0025
1908 Vascular cell adhesion protein 1 VCAM1 0.0025
1864 RET proto-oncogene RET 0.0025
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0024
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0024
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4773 Deoxycytidine kinase DCK 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
4226 Uridine phosphorylase 2 UPP2 0.0023
4192 DNA topoisomerase 2-beta TOP2B 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
65 Matrix metalloproteinase-9 Not Available 0.0023
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
1341 Histamine H3 receptor HRH3 0.0023
394 Calcineurin subunit B isoform 1 PPP3R1 0.0022
6742 Recoverin RCVRN 0.0022
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0022
2528 Fatty acid metabolism regulator protein fadR 0.0022
6740 Fatty acid metabolism regulator protein fadR 0.0022
6753 Apolipoprotein M APOM 0.0022
6747 Chalcone/stilbene synthase family protein MT1417 0.0022
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0022
6743 Non-fluorescent flavoprotein luxF 0.0022
6751 Gag polyprotein gag 0.0022
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0022
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0022
6749 Polyprotein Not Available 0.0022
2207 Rhodopsin RHO 0.0022
3404 Exotoxin A eta 0.0022
2320 Thymidine kinase, cytosolic TK1 0.0022
896 Glutathione S-transferase Mu 1 GSTM1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
4225 Uridine phosphorylase 1 UPP1 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
2091 Endoplasmin HSP90B1 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
735 Alanine aminotransferase 1 GPT 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
3904 Alanine aminotransferase 2 GPT2 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0021
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0021
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
594 Thyroxine-binding globulin SERPINA7 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
2021 Thrombomodulin THBD 0.002
413 Amidophosphoribosyltransferase PPAT 0.002
2515 Amidophosphoribosyltransferase purF 0.002
3714 Amidophosphoribosyltransferase purF 0.002
1820 Beta-nerve growth factor NGF 0.002
5961 Insulin INS 0.002
6218 Pannexin-1 PANX1 0.0019
3917 Methylenetetrahydrofolate reductase MTHFR 0.0019
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
2216 Fibroblast growth factor receptor 4 FGFR4 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
6755 Poliovirus receptor PVR 0.0019
6527 Lymphocyte antigen 96 LY96 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
6228 Nuclear receptor coactivator 1 NCOA1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
4948 Cytochrome c-553 Not Available 0.0019
4923 Cytochrome c3 DvMF_2499 0.0019
4945 Cytochrome c3 Not Available 0.0019
4949 Cytochrome c3 DVU_3171 0.0019
4968 Cytochrome c3 cytc3 0.0019
4997 Cytochrome c3 SO_2727 0.0019
5219 Cytochrome c3 cyd 0.0019
4902 Nine-heme cytochrome c Ddes_2038 0.0019
3189 High-molecular-weight cytochrome c hmcA 0.0019
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0018
489 Monocarboxylate transporter 2 SLC16A7 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
6750 ADP-ribosylation factor 6 ARF6 0.0018
6524 Protein tonB tonB 0.0018
4954 Soluble cytochrome b558 Not Available 0.0018
4925 Cytochrome c-type protein SHP shp 0.0018
4934 Cytochrome c-551 nirM 0.0018
5218 Cytochrome c-551 nirM 0.0018
4915 Cytochrome c-550 psbV 0.0018
4959 Cytochrome c-550 psbV 0.0018
5216 Cytochrome c-550 psbV 0.0018
4905 Cytochrome c2 Not Available 0.0018
4939 Cytochrome c2 cycA 0.0018
4964 Cytochrome c2 cycA 0.0018
4979 Cytochrome c2 cycA 0.0018
6673 Cytochrome c2 cycA 0.0018
4947 Bacterial hemoglobin vhb 0.0018
4975 Cytochrome c-556 RPA3973 0.0018
4916 Cyanoglobin glbN 0.0018
4943 Cytochrome c6 petJ 0.0018
4998 Hemoglobin-like protein yjbI yjbI 0.0018
4984 Neuroglobin NGB 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
3116 Bacterioferritin bfr 0.0018
4906 Bacterioferritin bfr 0.0018
4965 Bacterioferritin bfr 0.0018
4936 Cytochrome c2 iso-2 Not Available 0.0018
4994 Hemoglobin-like protein HbO glbO 0.0018
4907 Cytochrome c-L moxG 0.0018
6865 Cytochrome c-L moxG 0.0018
4909 CooA protein cooA 0.0018
644 Heme oxygenase 2 HMOX2 0.0018
4982 Heme oxygenase 2 pbsA2 0.0018
4942 Diheme cytochrome c napB napB 0.0018
4910 Cytoglobin CYGB 0.0018
4981 Iron-starvation protein PigA pigA 0.0018
4935 Cytochrome c-554 cycA1 0.0018
5000 HemO hemO 0.0018
4961 Hemophore HasA hasA 0.0018
4971 Nonaheme cytochrome c hmcA 0.0018
4904 Cytochrome c family protein GSU1996 0.0018
4976 Apocytochrome f petA 0.0018
6407 Apocytochrome f petA 0.0018
4989 Cytochrome c551 peroxidase ccp 0.0018
5222 Cytochrome c551 peroxidase ccpA 0.0018
4999 Cytochrome P450 165B3 CYP165B3 0.0018
4764 Cytochrome P450 165C4 CYP165C4 0.0018
4960 Putative cytochrome P450-family protein SCO7417 0.0018
4931 Cytochrome P450 167A1 CYP167A1 0.0018
4926 Heme-based aerotactic transducer hemAT hemAT 0.0018
4937 Cytochrome oxidase subunit II rcoxA 0.0018
4903 Methyl-accepting chemotaxis protein Tar4 0.0018
4993 Hydroxylamine oxidoreductase hao1 0.0018
4972 P450cin cinA 0.0018
4922 Cytochrome c, putative SO_4144 0.0018
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0018
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0018
3093 Catalase HPII katE 0.0018
4952 Catalase/peroxidase katA 0.0018
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6163 Copper-transporting ATPase 2 ATP7B 0.0017
6165 Copper-transporting ATPase 1 ATP7A 0.0017
2616 Ganglioside GM2 activator GM2A 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
4386 Hemoglobin-like protein HbN glbN 0.0016
1243 Cathepsin D CTSD 0.0016
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
76 Nitric-oxide synthase, brain NOS1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
2297 Genome polyprotein Not Available 0.0015
2322 Genome polyprotein Not Available 0.0015
2694 Genome polyprotein Not Available 0.0015
2719 Genome polyprotein Not Available 0.0015
2860 Genome polyprotein Not Available 0.0015
2928 Genome polyprotein Not Available 0.0015
3160 Genome polyprotein Not Available 0.0015
3260 Genome polyprotein Not Available 0.0015
4783 Genome polyprotein Not Available 0.0015
5726 Genome polyprotein Not Available 0.0015
5779 Genome polyprotein Not Available 0.0015
5867 Genome polyprotein Not Available 0.0015
6253 Genome polyprotein Not Available 0.0015
6301 Genome polyprotein Not Available 0.0015
6380 Genome polyprotein Not Available 0.0015
6381 Genome polyprotein Not Available 0.0015
6437 Genome polyprotein Not Available 0.0015
6520 Genome polyprotein Not Available 0.0015
6521 Genome polyprotein Not Available 0.0015
6652 Genome polyprotein Not Available 0.0015
6734 Genome polyprotein Not Available 0.0015
6735 Genome polyprotein Not Available 0.0015
6736 Genome polyprotein Not Available 0.0015
6737 Genome polyprotein Not Available 0.0015
6738 Genome polyprotein Not Available 0.0015
6739 Genome polyprotein Not Available 0.0015
6744 Genome polyprotein Not Available 0.0015
6748 Genome polyprotein Not Available 0.0015
6894 Genome polyprotein Not Available 0.0015
6898 Genome polyprotein Not Available 0.0015
6316 ADP-ribosylation factor 1 ARF1 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
3221 Cytochrome c4 cc4 0.0015
864 Gag-Pol polyprotein gag-pol 0.0014
2237 Gag-Pol polyprotein gag-pol 0.0014
2326 Gag-Pol polyprotein gag-pol 0.0014
2451 Gag-Pol polyprotein gag-pol 0.0014
2901 Gag-Pol polyprotein gag-pol 0.0014
3165 Gag-Pol polyprotein gag-pol 0.0014
3722 Gag-Pol polyprotein gag-pol 0.0014
6306 Gag-Pol polyprotein gag-pol 0.0014
6624 Gag-Pol polyprotein gag-pol 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
1792 Tissue-type plasminogen activator PLAT 0.0014
2298 Cytochrome P450-cam camC 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
4920 Peroxidase/catalase katG 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6168 Solute carrier family 22 member 16 SLC22A16 0.0013
2119 Cytochrome b5 CYB5A 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
4990 PpcA ppcA 0.0013
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0013
3375 Acidic cytochrome c3 Not Available 0.0013
4988 Sulfite oxidase, mitochondrial SUOX 0.0013
4385 Cytochrome c' Not Available 0.0013
4967 Cytochrome c' cycA 0.0013
5038 Cytochrome c' Not Available 0.0013
5223 Cytochrome c' cycP 0.0013
2915 Sensor protein fixL fixL 0.0013
4944 Sensor protein fixL fixL 0.0013
3570 Cytochrome P450 152A1 cypC 0.0013
4037 Hypothetical protein GPX1 0.0013
4297 Hypothetical protein SP_1951 0.0013
4521 Hypothetical protein BC_2969 0.0013
4540 Hypothetical protein TM_1070 0.0013
4555 Hypothetical protein MT1739 0.0013
4569 Hypothetical protein mshD 0.0013
4578 Hypothetical protein PA3270 0.0013
4747 Hypothetical protein PA3967 0.0013
5177 Hypothetical protein TM_0096 0.0013
5194 Hypothetical protein PA1204 0.0013
5240 Hypothetical protein Rv2991 0.0013
5370 Hypothetical protein TM_1158 0.0013
5710 Hypothetical protein Tb927.5.1360 0.0013
4992 Cytochrome c peroxidase Not Available 0.0013
4813 Heme oxygenase hmuO 0.0013
5769 Heme oxygenase Not Available 0.0013
4289 Cytochrome P450 TT_P0059 0.0013
6262 Cytochrome P450 staP 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2230 Catalase CAT 0.0013
3249 Catalase katA 0.0013
3625 Catalase katA 0.0013
4539 Catalase katA 0.0013
4941 Catalase katB 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
2427 Ferrichrome-iron receptor fhuA 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0011
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
3670 Soluble cytochrome b562 precursor cybC 0.0011
3411 Cytochrome P450 121 cyp121 0.0011
3291 Cytochrome c-552 cycA 0.0011
4927 Cytochrome c-552 nrfA 0.0011
4938 Cytochrome c-552 cycA 0.0011
4953 Cytochrome c-552 nrfA 0.0011
5217 Cytochrome c-552 cycM 0.0011
2617 Nitric oxide synthase oxygenase nos 0.0011
2701 Nitric oxide synthase oxygenase nos 0.0011
3102 Flavohemoprotein hmp 0.0011
4969 Flavohemoprotein hmp 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.001
2972 6-deoxyerythronolide B hydroxylase eryF 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
4608 Putative cytochrome P450 SCO1207 0.0009
4963 Putative cytochrome P450 SCO2884 0.0009
6254 Putative cytochrome P450 SCO6998 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
358 Cystathionine beta-synthase CBS 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
6677 Myelin P2 protein PMP2 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
693 Hemoglobin subunit beta HBB 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
1867 Major prion protein PRNP 0.0008
6268 Hydroxyacid oxidase 1 HAO1 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
810 Heme oxygenase 1 HMOX1 0.0008
3391 Heme oxygenase 1 pbsA1 0.0008
1025 Aquaporin-1 AQP1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
822 Aldose reductase AKR1B1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
798 Osteocalcin BGLAP 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
2240 Cell division protein kinase 2 CDK2 0.0003
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