DT-Web: DB00514

Identification

Name

Dextromethorphan

Accession Number

DB00514 (APRD00655)

Type

small molecule

Description

The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

271.3972

Groups

approved

Monoisotopic Weight

271.193614427

Pharmacology

Indication

For treatment and relief of dry cough.

Mechanism of action

Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan.

Absorption

Rapidly absorbed from the gastrointestinal tract.

Protein binding

Not Available

Biotransformation

Hepatic. Rapidly and extensively metabolized to dextrorphan (active metabolite). One well known metabolic catalyst involved is a specific cytochrome P450 enzyme known as 2D6, or CYP2D6.

Route of elimination

Not Available

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Abiraterone	Abiraterone increases levels by affecting CYP2D6 metabolism. Interaction is significant so monitor closely.
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dihydroquinidine barbiturate	Quinidine increases the toxicity of dextromethorphan
Fluoxetine	Combination associated with possible serotoninergic syndrome
Isocarboxazid	Possible severe adverse reaction
Moclobemide	Increased CNS toxicity
Paroxetine	Combination associated with possible serotoninergic syndrome
Phenelzine	Possible severe adverse reaction
Quinidine	Quinidine increases the toxicity of dextromethorphan
Quinidine barbiturate	Quinidine increases the toxicity of dextromethorphan
Rasagiline	Possible severe adverse reaction
Selegiline	Combination associated with possible serotoninergic syndrome
Sibutramine	Combination associated with possible serotoninergic syndrome
Terbinafine	Terbinafine may reduce the metabolism and clearance of Dextromethorphan. Consider alternate therapy or monitor for therapeutic/adverse effects of Dextromethorphan if Terbinafine is initiated, discontinued or dose changed.
Tocilizumab	Dextromethorphan is a CYP2D6 and CYP3A4 substrate. Exposure of dextromethorphan decreases following administration of tocilizumab.
Tramadol	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant use should be avoided.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Vemurafenib	Vemurafenib increases the AUC (CYP2D6 substrate) by 47% .
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Vilazodone	Consideration should be given to avoiding the concomitant use of dextromethorphan and selective serotonin reuptake inhibitors (SSRI). Monitor for toxic effects of dextromethorphan (eg, CNS, Cardiovascular) if an SSRI is initiated or the dose is increased. SSRIs, other than fluoxetine and paroxetine, may be safer alternatives due to lesser CYP2D6 inhibition; however, the mechanism for the interaction is not fully understood, and caution is still advised.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and dextromethorphan, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.

Food Interactions

Take without regard to meals.

Sigma 1-type opioid receptor
Name	Sigma 1-type opioid receptor
Gene Name	SIGMAR1
Pharmacological action	yes
Actions	agonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Shin EJ, Nah SY, Chae JS, Bing G, Shin SW, Yen TP, Baek IH, Kim WK, Maurice T, Nabeshima T, Kim HC: Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats. Neurochem Int. 2007 May;50(6):791-9. Epub 2007 Feb 4. - Pubmed Shin EJ, Nah SY, Kim WK, Ko KH, Jhoo WK, Lim YK, Cha JY, Chen CF, Kim HC: The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. Br J Pharmacol. 2005 Apr;144(7):908-18. - Pubmed Church AJ, Andrew RD: Spreading depression expands traumatic injury in neocortical brain slices. J Neurotrauma. 2005 Feb;22(2):277-90. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.491
Opioid receptor, sigma 1
Name	Opioid receptor, sigma 1
Gene Name	OPRS1
Pharmacological action	yes
Actions	agonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Chou YC, Liao JF, Chang WY, Lin MF, Chen CF: Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan. Brain Res. 1999 Mar 13;821(2):516-9. - Pubmed
DTHybrid score	0.2657
Glutamate [NMDA] receptor subunit 3A
Name	Glutamate [NMDA] receptor subunit 3A
Gene Name	GRIN3A
Pharmacological action	yes
Actions	antagonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Chou YC, Liao JF, Chang WY, Lin MF, Chen CF: Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan. Brain Res. 1999 Mar 13;821(2):516-9. - Pubmed Wong BY, Coulter DA, Choi DW, Prince DA: Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize N-methyl-D-aspartate in brain slices. Neurosci Lett. 1988 Feb 29;85(2):261-6. - Pubmed Kamel IR, Wendling WW, Chen D, Wendling KS, Harakal C, Carlsson C: N-methyl-D-aspartate (NMDA) antagonists--S(+)-ketamine, dextrorphan, and dextromethorphan--act as calcium antagonists on bovine cerebral arteries. J Neurosurg Anesthesiol. 2008 Oct;20(4):241-8. - Pubmed
DTHybrid score	0.3638
Neuronal acetylcholine receptor subunit alpha-2
Name	Neuronal acetylcholine receptor subunit alpha-2
Gene Name	CHRNA2
Pharmacological action	unknown
Actions	antagonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Damaj MI, Flood P, Ho KK, May EL, Martin BR: Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. J Pharmacol Exp Ther. 2005 Feb;312(2):780-5. Epub 2004 Sep 8. - Pubmed Lee JH, Shin EJ, Jeong SM, Kim JH, Lee BH, Yoon IS, Lee JH, Choi SH, Lee SM, Lee PH, Kim HC, Nah SY: Effects of dextrorotatory morphinans on alpha3beta4 nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur J Pharmacol. 2006 Apr 24;536(1-2):85-92. Epub 2006 Mar 2. - Pubmed
DTHybrid score	0.6141
Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	unknown
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Codd EE, Shank RP, Schupsky JJ, Raffa RB: Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70. - Pubmed Henderson MG, Fuller RW: Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6. - Pubmed
DTHybrid score	0.3399

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Yu A, Haining RL: Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? Drug Metab Dispos. 2001 Nov;29(11):1514-20. - Pubmed
DTHybrid score	0.9887
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Zhou SF: Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clin Pharmacokinet. 2009;48(11):689-723. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed (C) Tianyi Zhang, Yongxin Zhu, and Chandrani Gunaratna. Simultaneous Determination of Metabolites from Multiple Cytochrome P450 Probe Substrates by Gradient Liquid Chromatography with UV Detection. - Source Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Zhang T, Zhu Y, Gunaratna C: Rapid and quantitative determination of metabolites from multiple cytochrome P450 probe substrates by gradient liquid chromatography-electrospray ionization-ion trap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 25;780(2):371-9. - Pubmed Yu A, Haining RL: Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? Drug Metab Dispos. 2001 Nov;29(11):1514-20. - Pubmed
DTHybrid score	0.7526
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5381
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.429
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Yu A, Haining RL: Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? Drug Metab Dispos. 2001 Nov;29(11):1514-20. - Pubmed
DTHybrid score	0.5269
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6228
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6831
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5088
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4126

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. - Pubmed
DTHybrid score	0.6431

Id	Partner name	Gene Name	Score
4200	Cytochrome P450 1A2	CYP1A2	0.4068
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.2089
847	Mu-type opioid receptor	OPRM1	0.1866
5718	Cytochrome P450 2A6	CYP2A6	0.1757
696	Kappa-type opioid receptor	OPRK1	0.1727
6024	Cytochrome P450 1A1	CYP1A1	0.1715
617	Muscarinic acetylcholine receptor M2	CHRM2	0.1634
502	5-hydroxytryptamine 2A receptor	HTR2A	0.1617
713	Sodium-dependent dopamine transporter	SLC6A3	0.1497
587	Serum albumin	ALB	0.1399
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.136
831	D(2) dopamine receptor	DRD2	0.1316
20	Prostaglandin G/H synthase 1	PTGS1	0.1271
467	Delta-type opioid receptor	OPRD1	0.1236
3923	Cholinesterase	BCHE	0.1221
492	Histamine H1 receptor	HRH1	0.1215
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1198
6145	Solute carrier family 22 member 1	SLC22A1	0.1154
6106	Cytochrome P450 2C18	CYP2C18	0.1075
103	Muscarinic acetylcholine receptor M1	CHRM1	0.1065
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1011
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0994
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0951
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0946
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0943
51	Muscarinic acetylcholine receptor M3	CHRM3	0.091
6144	Solute carrier family 22 member 2	SLC22A2	0.0904
556	Alpha-1A adrenergic receptor	ADRA1A	0.0858
862	Multidrug resistance-associated protein 1	ABCC1	0.0837
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0814
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0762
3811	Cytochrome P450 19A1	CYP19A1	0.0713
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0662
3941	Amine oxidase [flavin-containing] A	MAOA	0.0658
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0653
318	Alpha-2A adrenergic receptor	ADRA2A	0.0627
1729	Solute carrier family 22 member 6	SLC22A6	0.0623
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0619
638	D(3) dopamine receptor	DRD3	0.0613
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0608
1898	Cytochrome P450 1B1	CYP1B1	0.0608
3939	Amine oxidase [flavin-containing] B	MAOB	0.0593
290	Prostaglandin G/H synthase 2	PTGS2	0.0592
474	Acetylcholinesterase	ACHE	0.0574
776	Bile salt export pump	ABCB11	0.0568
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0564
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0561
766	Beta-2 adrenergic receptor	ADRB2	0.0529
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0511
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0498
6031	Cytochrome P450 3A43	CYP3A43	0.0493
260	Cytochrome P450 51	ERG11	0.0488
761	Cytochrome P450 51	ERG11	0.0488
3163	Cytochrome P450 51	cyp51	0.0488
432	D(4) dopamine receptor	DRD4	0.0484
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0482
731	HIV-1 protease	HIV-1 protease	0.0475
23	D(1A) dopamine receptor	DRD1	0.0467
871	Glucocorticoid receptor	NR3C1	0.0456
118	Organic cation/carnitine transporter 2	SLC22A5	0.0451
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0451
193	Beta-1 adrenergic receptor	ADRB1	0.045
632	Alpha-1B adrenergic receptor	ADRA1B	0.0447
136	Estrogen receptor	ESR1	0.044
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0439
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0426
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0422
468	Cytochrome P450 4A11	CYP4A11	0.041
2164	Multidrug resistance-associated protein 4	ABCC4	0.0408
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0407
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0406
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.04
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0399
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0391
6143	Solute carrier family 22 member 7	SLC22A7	0.0383
6147	Solute carrier family 22 member 3	SLC22A3	0.0383
6182	Cytochrome P450 2J2	CYP2J2	0.0381
6142	Solute carrier family 22 member 8	SLC22A8	0.038
465	Calmodulin	CALM1	0.0378
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0378
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0377
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0377
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.037
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0368
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0341
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.033
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0328
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0323
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0323
833	Organic cation/carnitine transporter 1	SLC22A4	0.032
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0303
122	P2Y purinoceptor 12	P2RY12	0.0303
131	Synaptic vesicular amine transporter	SLC18A2	0.03
789	Alpha-1D adrenergic receptor	ADRA1D	0.0297
817	DNA topoisomerase 2-alpha	TOP2A	0.0297
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0295
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0293
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0293
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0288
629	Alpha-2B adrenergic receptor	ADRA2B	0.0284
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0283
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0277
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.027
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0268
723	Cytosolic phospholipase A2	PLA2G4A	0.0267
6148	Multidrug resistance-associated protein 7	ABCC10	0.0263
614	Progesterone receptor	PGR	0.0261
378	Alpha-2C adrenergic receptor	ADRA2C	0.0259
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0259
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0255
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0253
427	Substance-P receptor	TACR1	0.0253
146	Androgen receptor	AR	0.0251
1656	CYP2B protein	CYP2B	0.025
811	Translocator protein	TSPO	0.0246
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0239
482	Glycine receptor subunit alpha-1	GLRA1	0.0239
4604	Liver carboxylesterase 1	CES1	0.0238
891	Dihydropteroate synthase	folP	0.0238
5359	Dihydropteroate synthase	folP	0.0238
7175	Dihydropteroate synthase	sulI	0.0238
504	Mast/stem cell growth factor receptor	KIT	0.0229
844	Epidermal growth factor receptor	EGFR	0.0225
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0224
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0224
94	5-hydroxytryptamine 4 receptor	HTR4	0.0223
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0218
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0218
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0215
4120	NADPH--cytochrome P450 reductase	POR	0.0213
737	Mineralocorticoid receptor	NR3C2	0.0211
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0211
6136	Multidrug resistance-associated protein 5	ABCC5	0.0208
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0208
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0208
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0207
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0207
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0207
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0207
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0207
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0207
1024	Solute carrier family 22 member 11	SLC22A11	0.0205
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0203
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0203
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0203
756	Sex hormone-binding globulin	SHBG	0.0202
2178	Metabotropic glutamate receptor 5	GRM5	0.0201
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0201
124	Histamine H2 receptor	HRH2	0.0201
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.02
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.02
1010	Cytochrome P450 51A1	CYP51A1	0.0199
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0199
6137	Multidrug resistance-associated protein 6	ABCC6	0.0198
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0198
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0198
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0198
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0198
380	Cytochrome P450 17A1	CYP17A1	0.0197
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0195
6141	Sodium/bile acid cotransporter	SLC10A1	0.0195
70	Type-1 angiotensin II receptor	AGTR1	0.0191
6220	Aryl hydrocarbon receptor	AHR	0.0189
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0187
777	Tumor necrosis factor	TNF	0.0187
161	Tubulin beta chain	TUBB	0.0186
312	Tubulin beta chain	TUB2	0.0186
705	Glutamate receptor 1	GRIA1	0.0184
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0183
29	Tubulin beta-1 chain	TUBB1	0.0181
6102	Arylamine N-acetyltransferase 2	NAT2	0.0179
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0179
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0179
407	Vascular endothelial growth factor receptor 2	KDR	0.0176
4096	Metabotropic glutamate receptor 3	GRM3	0.0174
1362	Metabotropic glutamate receptor 2	GRM2	0.0174
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0173
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0173
26	Vascular endothelial growth factor receptor 3	FLT4	0.0173
716	5-hydroxytryptamine 7 receptor	HTR7	0.0172
869	Estrogen receptor beta	ESR2	0.0171
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.017
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0169
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0169
818	50S ribosomal protein L10	rplJ	0.0167
232	Corticosteroid-binding globulin	SERPINA6	0.0166
32	Vascular endothelial growth factor receptor 1	FLT1	0.0165
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0165
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0163
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0159
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0158
916	Metabotropic glutamate receptor 1	GRM1	0.0157
952	Dipeptidyl peptidase 4	DPP4	0.0156
6014	Cytochrome P450 2A13	CYP2A13	0.0153
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0152
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0152
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.015
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0149
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0146
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0145
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0145
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0143
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0143
1757	Myeloperoxidase	MPO	0.0138
16	Adenosine A1 receptor	ADORA1	0.0138
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0137
6432	Transporter	snf	0.0137
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0136
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0136
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0136
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0136
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0135
365	Dihydrofolate reductase	DHFR	0.0135
2381	Dihydrofolate reductase	DFR1	0.0135
2833	Dihydrofolate reductase	Not Available	0.0135
2931	Dihydrofolate reductase	folA	0.0135
3544	Dihydrofolate reductase	folA	0.0135
3682	Dihydrofolate reductase	folA	0.0135
6642	Dihydrofolate reductase	folA	0.0135
6756	Dihydrofolate reductase	dfrA	0.0135
1178	Adenosine A2a receptor	ADORA2A	0.0133
694	Matrix protein 2	M	0.0133
1192	Sulfotransferase 1A1	SULT1A1	0.0132
4116	Dihydropteroate synthetase	Not Available	0.0131
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.013
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.013
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0128
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0127
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0127
295	Carbonic anhydrase 1	CA1	0.0126
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0126
251	Alcohol dehydrogenase 1A	ADH1A	0.0124
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0122
373	Transthyretin	TTR	0.0121
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0121
6020	Aldehyde oxidase	AOX1	0.0121
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.012
163	D(1B) dopamine receptor	DRD5	0.012
444	Alcohol dehydrogenase 1B	ADH1B	0.012
738	Monocarboxylate transporter 1	SLC16A1	0.012
921	Glutamate receptor 2	GRIA2	0.0119
593	Proton-coupled amino acid transporter 1	SLC36A1	0.0118
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0117
592	Carbonic anhydrase 4	CA4	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0113
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
2539	Tubulin alpha-1 chain	TUBA4A	0.0112
3947	Xanthine dehydrogenase/oxidase	XDH	0.0111
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.011
6085	Fatty acid-binding protein, intestinal	FABP2	0.011
1618	High affinity nerve growth factor receptor	NTRK1	0.011
477	DNA topoisomerase 4 subunit A	parC	0.0109
886	DNA topoisomerase 4 subunit A	parC	0.0109
6226	DNA topoisomerase 4 subunit A	parC	0.0109
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0108
404	DNA gyrase subunit A	gyrA	0.0108
6224	DNA gyrase subunit A	gyrA	0.0108
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0107
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0106
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0106
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0106
4122	Histone deacetylase 2	HDAC2	0.0106
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0105
6138	Multidrug resistance protein 3	ABCB4	0.0105
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0104
165	FL cytokine receptor	FLT3	0.0104
3810	Catechol O-methyltransferase	COMT	0.0102
823	Fibroblast growth factor receptor 2	FGFR2	0.0102
3932	Glutathione S-transferase A2	GSTA2	0.0101
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0101
469	Annexin A1	ANXA1	0.01
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0099
904	Glutathione S-transferase P	GSTP1	0.0097
2112	Toll-like receptor 9	TLR9	0.0097
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0097
517	Alcohol dehydrogenase 1C	ADH1C	0.0097
4203	Histamine N-methyltransferase	HNMT	0.0096
5300	Antigen peptide transporter 1	TAP1	0.0096
49	Endothelin B receptor	EDNRB	0.0096
1050	Bile salt sulfotransferase	SULT2A1	0.0095
84	Nuclear receptor 0B1	NR0B1	0.0095
814	Ryanodine receptor 1	RYR1	0.0095
4237	50S ribosomal protein L22	rplV	0.0095
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0094
1517	Beta-3 adrenergic receptor	ADRB3	0.0094
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0092
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0092
1852	Microtubule-associated protein 2	MAP2	0.0091
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.009
578	Endothelin-1 receptor	EDNRA	0.009
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.009
153	Dopamine beta-hydroxylase	DBH	0.009
820	Glycine receptor subunit alpha-2	GLRA2	0.009
1353	DNA topoisomerase 1	TOP1	0.0089
3552	DNA topoisomerase 1	topA	0.0089
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0088
239	Coagulation factor X	F10	0.0087
357	Carbonic anhydrase 2	CA2	0.0087
275	Arachidonate 5-lipoxygenase	ALOX5	0.0086
88	Retinoic acid receptor RXR-beta	RXRB	0.0085
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0084
6126	Carbonic anhydrase 7	CA7	0.0084
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0084
4238	50S ribosomal protein L4	rplD	0.0083
5578	50S ribosomal protein L4	rplD	0.0083
6173	50S ribosomal protein L4	rplD	0.0083
6219	50S ribosomal protein L4	rplD	0.0083
1483	Membrane copper amine oxidase	AOC3	0.0081
273	Apoptosis regulator Bcl-2	BCL2	0.0081
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.008
1196	Complement decay-accelerating factor	CD55	0.008
518	Peroxidase/catalase T	katG	0.008
1630	Integrin beta-2	ITGB2	0.0079
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0079
3601	Dihydropteroate synthase 1	folP1	0.0079
3807	Dihydropteroate synthase 1	folP1	0.0079
3808	Dihydropteroate synthase 2	folP2	0.0079
976	Platelet glycoprotein IX	GP9	0.0079
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0079
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
3809	Estrogen-related receptor gamma	ESRRG	0.0077
183	Vascular endothelial growth factor A	VEGFA	0.0076
244	Angiotensin-converting enzyme	ACE	0.0076
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0076
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0076
54	Prothrombin	F2	0.0076
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0076
24	Thymidylate synthase	TMP1	0.0076
359	Thymidylate synthase	TYMS	0.0076
2626	Thymidylate synthase	thyA	0.0076
2729	Thymidylate synthase	thyA	0.0076
5352	Thymidylate synthase	THYA	0.0076
563	Thyroid peroxidase	TPO	0.0075
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0075
4311	tRNA	TRDMT1	0.0075
4325	tRNA	trmD	0.0075
4328	tRNA	trmD	0.0075
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0075
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0075
1541	Metalloproteinase	mmp20	0.0074
613	Atrial natriuretic peptide receptor A	NPR1	0.0074
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0073
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0073
1268	Neuropeptide S receptor	NPSR1	0.0073
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0073
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0072
5923	Microtubule-associated protein tau	MAPT	0.0071
5924	Microtubule-associated protein 4	MAP4	0.0071
6174	50S ribosomal protein L32	rpmF	0.0071
856	Vitamin D3 receptor	VDR	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
571	Melatonin receptor type 1A	MTNR1A	0.007
362	Melatonin receptor type 1B	MTNR1B	0.007
284	DNA-directed RNA polymerase beta chain	rpoB	0.007
5773	DNA-directed RNA polymerase beta chain	rpoB	0.007
1629	Transcription factor AP-1	JUN	0.007
780	Retinoic acid receptor RXR-gamma	RXRG	0.007
2808	Chloramphenicol acetyltransferase 3	cat3	0.0069
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0069
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0069
68	Cannabinoid receptor 1	CNR1	0.0068
3086	Plasmepsin-2	Not Available	0.0068
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0067
3904	Alanine aminotransferase 2	GPT2	0.0067
735	Alanine aminotransferase 1	GPT	0.0067
3913	Glutamic acid decarboxylase	GAD65	0.0066
6073	Potassium channel subfamily K member 9	KCNK9	0.0066
6072	Potassium channel subfamily K member 3	KCNK3	0.0066
581	Cytochrome P450 2R1	CYP2R1	0.0065
7	Nitric oxide synthase, inducible	NOS2	0.0065
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0065
1636	Trace amine-associated receptor 1	TAAR1	0.0064
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0064
1275	Estrogen sulfotransferase	SULT1E1	0.0064
2417	Chloramphenicol acetyltransferase	cat	0.0063
3278	Chloramphenicol acetyltransferase	cat	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0063
133	Dihydropterate synthase	sulI	0.0063
2810	Dr hemagglutinin structural subunit	draA	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
2449	Tubulin alpha-3 chain	TUBA1A	0.0062
4773	Deoxycytidine kinase	DCK	0.0062
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0062
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0061
2207	Rhodopsin	RHO	0.0061
162	Retinoic acid receptor gamma-1	RARG	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0059
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0059
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0059
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0059
5787	Angiopoietin-1 receptor	TEK	0.0059
4103	Proteasome subunit beta type 2	PSMB2	0.0059
4102	Proteasome subunit beta type 5	PSMB5	0.0059
4101	Proteasome subunit beta type 1	PSMB1	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
3856	Fibroblast growth factor receptor 3	FGFR3	0.0058
634	Squalene monooxygenase	SQLE	0.0057
7196	Squalene monooxygenase	ERG1	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
6146	High affinity copper uptake protein 1	SLC31A1	0.0057
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0056
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0056
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0056
6506	Stathmin-4	STMN4	0.0055
558	Solute carrier family 12 member 1	SLC12A1	0.0054
3937	Fatty-acid amide hydrolase	FAAH	0.0054
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0054
65	Matrix metalloproteinase-9	Not Available	0.0054
6044	Serum paraoxonase/lactonase 3	PON3	0.0054
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0052
5934	Cytochrome P450 26A1	CYP26A1	0.0052
1262	Corticotropin-lipotropin	POMC	0.0052
1992	Vitamin D-binding protein	GC	0.0052
3090	Chitosanase	csn	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
908	Glutathione S-transferase theta-1	GSTT1	0.0051
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0051
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.005
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.005
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.005
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.005
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.005
3868	Calcineurin subunit B isoform 2	PPP3R2	0.005
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.005
572	Integrin alpha-L	ITGAL	0.005
6048	Troponin C, skeletal muscle	TNNC2	0.005
267	Plasminogen activator inhibitor 1	SERPINE1	0.0049
719	Retinoic acid receptor responder protein 1	RARRES1	0.0049
770	Retinoic acid-induced protein 3	GPRC5A	0.0049
3404	Exotoxin A	eta	0.0049
173	Toll-like receptor 7	TLR7	0.0049
2230	Catalase	CAT	0.0048
3249	Catalase	katA	0.0048
3625	Catalase	katA	0.0048
4539	Catalase	katA	0.0048
4941	Catalase	katB	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
33	Cystine/glutamate transporter	SLC7A11	0.0048
6766	O-GlcNAcase BT_4395	BT_4395	0.0048
751	Potassium channel subfamily K member 6	KCNK6	0.0048
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0048
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
1253	Interferon gamma	IFNG	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
1648	Elastin	ELN	0.0046
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0046
936	Ephrin type-A receptor 2	EPHA2	0.0046
4192	DNA topoisomerase 2-beta	TOP2B	0.0045
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0045
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0045
6824	Tyrosine-protein kinase Lyn	LYN	0.0045
790	DNA polymerase subunit alpha B	POLA2	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
6221	Steroid hormone receptor ERR1	ESRRA	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
172	Potassium channel subfamily K member 1	KCNK1	0.0044
164	Histamine H4 receptor	HRH4	0.0043
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
569	Retinal dehydrogenase 2	ALDH1A2	0.0043
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0042
6043	Putative G-protein coupled receptor 44	GPR44	0.0041
1864	RET proto-oncogene	RET	0.0041
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0041
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0041
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
106	Cannabinoid receptor 2	CNR2	0.004
6149	Solute carrier family 22 member 10	SLC22A10	0.004
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.004
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.004
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.004
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.004
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.004
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.004
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.004
611	Retinal dehydrogenase 1	ALDH1A1	0.004
459	Retinoic acid receptor RXR-alpha	RXRA	0.004
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0038
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0038
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0038
85	Growth hormone receptor	GHR	0.0038
594	Thyroxine-binding globulin	SERPINA7	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
5798	Mitogen-activated protein kinase 11	MAPK11	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
390	Adenosine A3 receptor	ADORA3	0.0037
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0037
1374	Natriuretic peptides B	NPPB	0.0036
1827	Gap junction alpha-1 protein	GJA1	0.0036
1908	Vascular cell adhesion protein 1	VCAM1	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0036
2216	Fibroblast growth factor receptor 4	FGFR4	0.0035
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0035
2300	Lysozyme	E	0.0035
3633	Lysozyme	R	0.0035
5597	Lysozyme	17	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0034
758	Thyroid hormone receptor alpha	THRA	0.0034
4217	Telomerase reverse transcriptase	TERT	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
1039	Histone deacetylase 9	HDAC9	0.0034
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0034
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0034
268	Adenosine A2b receptor	ADORA2B	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0033
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0032
291	Nitric-oxide synthase, endothelial	NOS3	0.0032
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
229	Retinoic acid receptor beta	RARB	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
3957	Adenosine deaminase	ADA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
730	Retinoic acid receptor alpha	RARA	0.0031
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
346	Thyroid hormone receptor beta-1	THRB	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
1650	Heme carrier protein 1	SLC46A1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
2298	Cytochrome P450-cam	camC	0.003
2599	Tyrosine-protein kinase HCK	HCK	0.003
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.003
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.003
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
3426	Glutamine synthetase	glnA	0.0029
3987	Glutamine synthetase	GLUL	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
6459	Glycodelin	PAEP	0.0028
605	Fumarate reductase flavoprotein subunit	frdA	0.0028
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0028
3673	Fumarate reductase flavoprotein subunit	fccA	0.0028
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0028
6549	Fumarate reductase flavoprotein subunit	frdA	0.0028
1291	cAMP response element-binding protein	CREB1	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
896	Glutathione S-transferase Mu 1	GSTM1	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
199	Monocarboxylate transporter 8	SLC16A2	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0027
4210	Toll-like receptor 4	TLR4	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
358	Cystathionine beta-synthase	CBS	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
2320	Thymidine kinase, cytosolic	TK1	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0026
992	Protein tyrosine kinase 2 beta	PTK2B	0.0026
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0025
2021	Thrombomodulin	THBD	0.0025
3639	Thymidine phosphorylase	deoA	0.0025
3936	Thymidine phosphorylase	TYMP	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6163	Copper-transporting ATPase 2	ATP7B	0.0025
6165	Copper-transporting ATPase 1	ATP7A	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
489	Monocarboxylate transporter 2	SLC16A7	0.0025
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
6151	Monocarboxylate transporter 10	SLC16A10	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6218	Pannexin-1	PANX1	0.0024
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
6131	Carbonic anhydrase 14	CA14	0.0023
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0023
543	Penicillin-binding protein 1B	mrcB	0.0023
6186	Penicillin-binding protein 1B	ponB	0.0023
6822	Penicillin-binding protein 1b	pbp1b	0.0023
6844	Penicillin-binding protein 1b	pbp1b	0.0023
3221	Cytochrome c4	cc4	0.0023
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6122	Carbonic anhydrase 3	CA3	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.002
1063	Signal transducer and activator of transcription 5B	STAT5B	0.002
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.002
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.002
293	Gamma-glutamyl hydrolase	GGH	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0019
484	Tyrosine-protein kinase ABL2	ABL2	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
6167	Organic solute transporter subunit beta	OSTB	0.0019
6166	Organic solute transporter subunit alpha	OSTA	0.0019
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0019
760	Fibroblast growth factor 1	FGF1	0.0019
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
1792	Tissue-type plasminogen activator	PLAT	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
3830	Calreticulin	CALR	0.0017
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0017
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0017
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0017
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0017
6168	Solute carrier family 22 member 16	SLC22A16	0.0017
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0017
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0016
6837	Serine/threonine-protein kinase 17B	STK17B	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0016
4226	Uridine phosphorylase 2	UPP2	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2408	Tyrosine-protein kinase SYK	SYK	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0015
6677	Myelin P2 protein	PMP2	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
922	Glutamate receptor 4	GRIA4	0.0015
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0015
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0015
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0015
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0015
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0015
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0015
4018	Glutamate receptor delta-2 subunit	GRID2	0.0015
4027	Glutamate receptor delta-1 subunit	GRID1	0.0015
1912	Excitatory amino acid transporter 1	SLC1A3	0.0015
4019	Excitatory amino acid transporter 4	SLC1A6	0.0015
4016	Excitatory amino acid transporter 5	SLC1A7	0.0015
4026	Aspartyl aminopeptidase	DNPEP	0.0015
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0015
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0015
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0015
1047	Excitatory amino acid transporter 2	SLC1A2	0.0015
664	Glutamate decarboxylase 2	GAD2	0.0015
3890	Glutamate decarboxylase 2	GAD2	0.0015
4017	5-oxoprolinase	OPLAH	0.0015
927	Metabotropic glutamate receptor 8	GRM8	0.0015
925	Metabotropic glutamate receptor 4	GRM4	0.0015
926	Metabotropic glutamate receptor 7	GRM7	0.0015
4020	Glutamyl aminopeptidase	ENPEP	0.0015
4225	Uridine phosphorylase 1	UPP1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0014
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0014
76	Nitric-oxide synthase, brain	NOS1	0.0014
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
413	Amidophosphoribosyltransferase	PPAT	0.0014
2515	Amidophosphoribosyltransferase	purF	0.0014
3714	Amidophosphoribosyltransferase	purF	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
3007	Carbonic anhydrase 12	CA12	0.0014
4205	Carbonic anhydrase 9	CA9	0.0014
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
625	Glutamate carboxypeptidase 2	FOLH1	0.0013
400	Coagulation factor IX	F9	0.0013
5461	Coagulation factor IX	F9	0.0013
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0013
665	Phosphoserine aminotransferase	PSAT1	0.0013
4652	Phosphoserine aminotransferase	serC	0.0013
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0013
420	Glutamate decarboxylase 1	GAD1	0.0013
3900	Glutamate decarboxylase 1	GAD1	0.0013
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0013
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0013
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0013
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0013
6042	Prostaglandin reductase 2	PTGR2	0.0013
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0013
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0013
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0013
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0013
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0013
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
4692	A/G-specific adenine glycosylase	mutY	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
1714	Mitogen-activated protein kinase 3	MAPK3	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
923	Glutamate receptor 3	GRIA3	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
1295	Fatty acid synthase	FASN	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0012
604	Vitamin K-dependent protein Z	PROZ	0.0012
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0012
3877	Growth-inhibiting protein 18	GIG18	0.0012
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0012
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0012
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6859	Protein S100-A4	S100A4	0.0012
763	Tyrosine aminotransferase	TAT	0.0012
5493	Tyrosine aminotransferase	Not Available	0.0012
1671	Excitatory amino acid transporter 3	SLC1A1	0.0012
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0011
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0011
2236	Casein kinase II subunit alpha	CSNK2A1	0.0011
422	Vitamin K-dependent protein C	PROC	0.0011
1245	Vitamin K-dependent protein S	PROS1	0.0011
2802	Endoglucanase G	celCCG	0.0011
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0011
6316	ADP-ribosylation factor 1	ARF1	0.0011
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0011
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.001
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.001
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
1313	Lactoylglutathione lyase	GLO1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.001
997	Protein kinase C beta type	PRKCB	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
798	Osteocalcin	BGLAP	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4943	Cytochrome c6	petJ	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4984	Neuroglobin	NGB	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
5000	HemO	hemO	0.0008
4910	Cytoglobin	CYGB	0.0008
4909	CooA protein	cooA	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4972	P450cin	cinA	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
3093	Catalase HPII	katE	0.0008
4952	Catalase/peroxidase	katA	0.0008
369	Coagulation factor VII	F7	0.0008
1867	Major prion protein	PRNP	0.0008
1507	Cytochrome c	CYCS	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
4920	Peroxidase/catalase	katG	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
5626	Nucleoside diphosphate kinase B	NME2	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
5294	Nucleoside diphosphate kinase A	NME1	0.0005
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00514 - Dextromethorphan

Targets

Enzymes

Transporters

Predictions