DT-Web: DB00998

Identification

Name

Frovatriptan

Accession Number

DB00998 (APRD00270)

Type

small molecule

Description

Frovatriptan (Frova(R)) is a triptan drug developed by Vernalis for the treatment of migraine headaches, in particular those associated with menstruation. The product is licensed to Endo Pharmaceuticals in North America and Menarini in Europe.[1] Frovatriptan causes vasoconstriction of arteries and veins that supply blood to the head. It is available as 2.5 mg tablets. Frovatriptan has mean terminal elimination half-life of approximately 26 hours, which is substantially longer than other triptans. Frovatriptan is available only by prescription in the United States, where a secondary New Drug Approval (sNDA) was filed in July 2006[2] and which is currently pending.[3] The FDA anticipates completing its review of this application on or before the current PDUFA (Prescription Drug User Fee Act) review date of August 19, 2007. If the sNDA is approved, Frova(R) will be the only medication indicated in the U.S. for the short-term prevention of menstrual migraine (MM).

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

243.3043

Groups

approved

Monoisotopic Weight

243.137162181

Pharmacology

Indication

For the acute treatment of migraine attacks with or without aura in adults.

Mechanism of action

Three distinct pharmacological actions have been implicated in the antimigraine effect of the triptans: (1) stimulation of presynaptic 5-HT_1D receptors, which serves to inhibit both dural vasodilation and inflammation; (2) direct inhibition of trigeminal nuclei cell excitability via 5-HT_1B/1D receptor agonism in the brainstem and (3) vasoconstriction of meningeal, dural, cerebral or pial vessels as a result of vascular 5-HT_1B receptor agonism.

Absorption

Frovatriptan is rapidly absorbed from the duodenum, but has low oral bioavailability.

Protein binding

Binding to serum proteins is low (approximately 15%). Reversible binding to blood cells at equilibrium is approximately 60%.

Biotransformation

In vitro, cytochrome P450 1A2 appears to be the principal enzyme involved in the metabolism of frovatriptan to several metabolites including hydroxylated frovatriptan, N-acetyl desmethyl frovatriptan, hydroxylated N-acetyl desmethyl frovatriptan and desmethyl frovatriptan, and several other minor metabolites. Desmethyl frovatriptan has lower affinity for 5-HT_1B/1D receptors compared to the parent compound. The N-acetyl desmethyl metabolite has no significant affinity for 5-HT receptors. The activity of the other metabolites is unknown.

Route of elimination

Radiolabeled compounds excreted in urine were unchanged frovatriptan, hydroxylated frovatriptan, N-acetyl desmethyl frovatriptan, hydroxylated N-acetyl desmethyl frovatriptan and desmethyl frovatriptan, together with several other minor metabolites. Less than 10% of frovatriptan was excreted in urine after an oral dose.

Toxicity

There is no direct experience of any patient taking an overdose of Frovatriptan. The maximum single dose of frovatriptan given to male and female patients with migraine was 40 mg (16 times the clinical dose) and the maximum single dose given to healthy male subjects was 100 mg (40 times the clinical dose) without significant adverse events.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Citalopram	Increased risk of CNS adverse effects
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dihydroergotamine	Possible severe and prolonged vasoconstriction
Dihydroergotoxine	Possible severe and prolonged vasoconstriction
Ergonovine	Possible severe and prolonged vasoconstriction
Ergotamine	Possible severe and prolonged vasoconstriction
Escitalopram	Increased risk of CNS adverse effects
Fluoxetine	Increased risk of CNS adverse effects
Fluvoxamine	Increased risk of CNS adverse effects
Methylergonovine	Possible severe and prolonged vasoconstriction
Methysergide	Possible severe and prolonged vasoconstriction
Nefazodone	Increased risk of CNS adverse effects
Paroxetine	Increased risk of CNS adverse effects
Sertraline	Increased risk of CNS adverse effects
Sibutramine	Increased risk of CNS adverse effects
Tramadol	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Tranylcypromine	Increased risk of serotonin syndrome. Use caution during concomitant therapy and monitor for symptoms of serotonin syndrome.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Zolmitriptan	Concomitant use of two serotonin 5-HT1D receptor agonists, such as zolmitriptan and frovatriptan, may result in additive vasoconstrictive effects. Concomitant use within 24 hours is contraindicated.

Food Interactions

Take without regard to meals.
Food does not affect amount of absorption but delays maximal levels by about 1 hour.

5-hydroxytryptamine 1D receptor
Name	5-hydroxytryptamine 1D receptor
Gene Name	HTR1D
Pharmacological action	yes
Actions	agonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Easthope SE, Goa KL: Frovatriptan. CNS Drugs. 2001;15(12):969-76; discussion 977-8. - Pubmed Comer MB: Pharmacology of the selective 5-HT(1B/1D) agonist frovatriptan. Headache. 2002 Apr;42 Suppl 2:S47-53. - Pubmed Tfelt-Hansen P, De Vries P, Saxena PR: Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy. Drugs. 2000 Dec;60(6):1259-87. - Pubmed Deleu D, Hanssens Y: Current and emerging second-generation triptans in acute migraine therapy: a comparative review. J Clin Pharmacol. 2000 Jul;40(7):687-700. - Pubmed Jahnichen S, Radtke OA, Pertz HH: Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery. Naunyn Schmiedebergs Arch Pharmacol. 2004 Jul;370(1):54-63. Epub 2004 Jun 8. - Pubmed Balbisi EA: Frovatriptan succinate, a 5-HT1B/1D receptor agonist for migraine. Int J Clin Pract. 2004 Jul;58(7):695-705. - Pubmed Parsons AA, Raval P, Smith S, Tilford N, King FD, Kaumann AJ, Hunter J: Effects of the novel high-affinity 5-HT(1B/1D)-receptor ligand frovatriptan in human isolated basilar and coronary arteries. J Cardiovasc Pharmacol. 1998 Aug;32(2):220-4. - Pubmed Balbisi EA: Frovatriptan: a review of pharmacology, pharmacokinetics and clinical potential in the treatment of menstrual migraine. Ther Clin Risk Manag. 2006 Sep;2(3):303-8. - Pubmed Elkind AH, Wade A, Ishkanian G: Pharmacokinetics of frovatriptan in adolescent migraineurs. J Clin Pharmacol. 2004 Oct;44(10):1158-65. - Pubmed Buchan P, Wade A, Ward C, Oliver SD, Stewart AJ, Freestone S: Frovatriptan: a review of drug-drug interactions. Headache. 2002 Apr;42 Suppl 2:S63-73. - Pubmed
DTHybrid score	0.2391
5-hydroxytryptamine 1B receptor
Name	5-hydroxytryptamine 1B receptor
Gene Name	HTR1B
Pharmacological action	yes
Actions	agonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Balbisi EA: Frovatriptan succinate, a 5-HT1B/1D receptor agonist for migraine. Int J Clin Pract. 2004 Jul;58(7):695-705. - Pubmed Comer MB: Pharmacology of the selective 5-HT(1B/1D) agonist frovatriptan. Headache. 2002 Apr;42 Suppl 2:S47-53. - Pubmed Parsons AA, Raval P, Smith S, Tilford N, King FD, Kaumann AJ, Hunter J: Effects of the novel high-affinity 5-HT(1B/1D)-receptor ligand frovatriptan in human isolated basilar and coronary arteries. J Cardiovasc Pharmacol. 1998 Aug;32(2):220-4. - Pubmed Easthope SE, Goa KL: Frovatriptan. CNS Drugs. 2001;15(12):969-76; discussion 977-8. - Pubmed Dodick DW, Sandrini G, Williams P: Use of the sustained pain-free plus no adverse events endpoint in clinical trials of triptans in acute migraine. CNS Drugs. 2007;21(1):73-82. - Pubmed Tfelt-Hansen P, De Vries P, Saxena PR: Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy. Drugs. 2000 Dec;60(6):1259-87. - Pubmed Deleu D, Hanssens Y: Current and emerging second-generation triptans in acute migraine therapy: a comparative review. J Clin Pharmacol. 2000 Jul;40(7):687-700. - Pubmed Markus F, Mikko K: Frovatriptan review. Expert Opin Pharmacother. 2007 Dec;8(17):3029-33. - Pubmed Balbisi EA: Frovatriptan: a review of pharmacology, pharmacokinetics and clinical potential in the treatment of menstrual migraine. Ther Clin Risk Manag. 2006 Sep;2(3):303-8. - Pubmed Elkind AH, Wade A, Ishkanian G: Pharmacokinetics of frovatriptan in adolescent migraineurs. J Clin Pharmacol. 2004 Oct;44(10):1158-65. - Pubmed Buchan P, Wade A, Ward C, Oliver SD, Stewart AJ, Freestone S: Frovatriptan: a review of drug-drug interactions. Headache. 2002 Apr;42 Suppl 2:S63-73. - Pubmed
DTHybrid score	0.2584

Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Easthope SE, Goa KL: Frovatriptan. CNS Drugs. 2001;15(12):969-76; discussion 977-8. - Pubmed Buchan P, Keywood C, Wade A, Ward C: Clinical pharmacokinetics of frovatriptan. Headache. 2002 Apr;42 Suppl 2:S54-62. - Pubmed Buchan P, Wade A, Ward C, Oliver SD, Stewart AJ, Freestone S: Frovatriptan: a review of drug-drug interactions. Headache. 2002 Apr;42 Suppl 2:S63-73. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2703

Id	Partner name	Gene Name	Score
320	5-hydroxytryptamine 1A receptor	HTR1A	0.1304
4512	Cytochrome P450 3A4	CYP3A4	0.1153
511	5-hydroxytryptamine 1F receptor	HTR1F	0.1048
4119	Cytochrome P450 2D6	CYP2D6	0.093
318	Alpha-2A adrenergic receptor	ADRA2A	0.0855
3941	Amine oxidase [flavin-containing] A	MAOA	0.0754
629	Alpha-2B adrenergic receptor	ADRA2B	0.0751
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0698
638	D(3) dopamine receptor	DRD3	0.0695
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0691
831	D(2) dopamine receptor	DRD2	0.0686
378	Alpha-2C adrenergic receptor	ADRA2C	0.0679
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0673
1588	Multidrug resistance protein 1	ABCB1	0.063
432	D(4) dopamine receptor	DRD4	0.0628
23	D(1A) dopamine receptor	DRD1	0.0598
6016	Cytochrome P450 2C19	CYP2C19	0.0593
4757	Cytochrome P450 2C9	CYP2C9	0.0556
163	D(1B) dopamine receptor	DRD5	0.0554
6024	Cytochrome P450 1A1	CYP1A1	0.0419
6013	Cytochrome P450 2E1	CYP2E1	0.0404
716	5-hydroxytryptamine 7 receptor	HTR7	0.0381
556	Alpha-1A adrenergic receptor	ADRA1A	0.038
4118	Cytochrome P450 3A5	CYP3A5	0.038
632	Alpha-1B adrenergic receptor	ADRA1B	0.0372
4924	Cytochrome P450 2C8	CYP2C8	0.0336
6107	Cytochrome P450 3A7	CYP3A7	0.0302
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0283
492	Histamine H1 receptor	HRH1	0.027
6030	Cytochrome P450 2B6	CYP2B6	0.027
193	Beta-1 adrenergic receptor	ADRB1	0.0261
36	Insulin receptor	INSR	0.0258
5718	Cytochrome P450 2A6	CYP2A6	0.0244
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0242
766	Beta-2 adrenergic receptor	ADRB2	0.024
789	Alpha-1D adrenergic receptor	ADRA1D	0.0235
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0211
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.021
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0193
20	Prostaglandin G/H synthase 1	PTGS1	0.0178
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0175
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0171
1517	Beta-3 adrenergic receptor	ADRB3	0.0166
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0156
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0153
617	Muscarinic acetylcholine receptor M2	CHRM2	0.015
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0148
587	Serum albumin	ALB	0.0146
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.014
6144	Solute carrier family 22 member 2	SLC22A2	0.0133
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0128
477	DNA topoisomerase 4 subunit A	parC	0.0127
886	DNA topoisomerase 4 subunit A	parC	0.0127
6226	DNA topoisomerase 4 subunit A	parC	0.0127
6145	Solute carrier family 22 member 1	SLC22A1	0.0127
404	DNA gyrase subunit A	gyrA	0.0125
6224	DNA gyrase subunit A	gyrA	0.0125
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0122
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0117
1898	Cytochrome P450 1B1	CYP1B1	0.0109
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
817	DNA topoisomerase 2-alpha	TOP2A	0.0096
290	Prostaglandin G/H synthase 2	PTGS2	0.009
3811	Cytochrome P450 19A1	CYP19A1	0.0086
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0083
824	Sodium-dependent serotonin transporter	SLC6A4	0.0082
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0081
1729	Solute carrier family 22 member 6	SLC22A6	0.0078
6106	Cytochrome P450 2C18	CYP2C18	0.0076
94	5-hydroxytryptamine 4 receptor	HTR4	0.0074
118	Organic cation/carnitine transporter 2	SLC22A5	0.007
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0069
3939	Amine oxidase [flavin-containing] B	MAOB	0.0067
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0066
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0066
16	Adenosine A1 receptor	ADORA1	0.0066
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.006
862	Multidrug resistance-associated protein 1	ABCC1	0.0055
1178	Adenosine A2a receptor	ADORA2A	0.0053
571	Melatonin receptor type 1A	MTNR1A	0.0052
362	Melatonin receptor type 1B	MTNR1B	0.0052
713	Sodium-dependent dopamine transporter	SLC6A3	0.0052
136	Estrogen receptor	ESR1	0.0049
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0049
847	Mu-type opioid receptor	OPRM1	0.0046
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0045
465	Calmodulin	CALM1	0.0045
6220	Aryl hydrocarbon receptor	AHR	0.0045
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0044
3923	Cholinesterase	BCHE	0.0044
777	Tumor necrosis factor	TNF	0.0044
714	Glutathione reductase, mitochondrial	GSR	0.0042
6143	Solute carrier family 22 member 7	SLC22A7	0.0041
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0041
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.004
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.004
164	Histamine H4 receptor	HRH4	0.004
124	Histamine H2 receptor	HRH2	0.004
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0039
833	Organic cation/carnitine transporter 1	SLC22A4	0.0039
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0037
5998	Toll-like receptor 8	TLR8	0.0035
273	Apoptosis regulator Bcl-2	BCL2	0.0034
1757	Myeloperoxidase	MPO	0.0034
565	Extracellular calcium-sensing receptor	CASR	0.0034
712	Tubulin alpha chain	TUB1	0.0034
161	Tubulin beta chain	TUBB	0.0034
312	Tubulin beta chain	TUB2	0.0034
6014	Cytochrome P450 2A13	CYP2A13	0.0034
3947	Xanthine dehydrogenase/oxidase	XDH	0.0034
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0033
4122	Histone deacetylase 2	HDAC2	0.0033
468	Cytochrome P450 4A11	CYP4A11	0.0033
613	Atrial natriuretic peptide receptor A	NPR1	0.0033
6147	Solute carrier family 22 member 3	SLC22A3	0.0032
6142	Solute carrier family 22 member 8	SLC22A8	0.0032
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0031
2164	Multidrug resistance-associated protein 4	ABCC4	0.0031
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0031
818	50S ribosomal protein L10	rplJ	0.003
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
173	Toll-like receptor 7	TLR7	0.003
117	Sterol O-acyltransferase 1	SOAT1	0.003
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0029
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0029
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0029
992	Protein tyrosine kinase 2 beta	PTK2B	0.0028
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0028
776	Bile salt export pump	ABCB11	0.0028
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0028
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0028
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0028
6044	Serum paraoxonase/lactonase 3	PON3	0.0028
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
5880	Thrombopoietin receptor	MPL	0.0025
6070	Nischarin	NISCH	0.0024
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
3957	Adenosine deaminase	ADA	0.0023
6148	Multidrug resistance-associated protein 7	ABCC10	0.0023
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0023
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0023
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0022
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0022
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
26	Vascular endothelial growth factor receptor 3	FLT4	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
731	HIV-1 protease	HIV-1 protease	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0021
260	Cytochrome P450 51	ERG11	0.0021
761	Cytochrome P450 51	ERG11	0.0021
3163	Cytochrome P450 51	cyp51	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0021
32	Vascular endothelial growth factor receptor 1	FLT1	0.0021
869	Estrogen receptor beta	ESR2	0.0021
871	Glucocorticoid receptor	NR3C1	0.0021
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.002
6020	Aldehyde oxidase	AOX1	0.002
1820	Beta-nerve growth factor	NGF	0.002
4228	Keratin, type II cytoskeletal 7	KRT7	0.002
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.002
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.002
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.002
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0019
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0019
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0019
284	DNA-directed RNA polymerase beta chain	rpoB	0.0019
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0019
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0019
122	P2Y purinoceptor 12	P2RY12	0.0018
33	Cystine/glutamate transporter	SLC7A11	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
504	Mast/stem cell growth factor receptor	KIT	0.0018
1648	Elastin	ELN	0.0017
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0017
275	Arachidonate 5-lipoxygenase	ALOX5	0.0017
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0017
1656	CYP2B protein	CYP2B	0.0017
407	Vascular endothelial growth factor receptor 2	KDR	0.0017
1830	5'-nucleotidase	NT5E	0.0016
390	Adenosine A3 receptor	ADORA3	0.0016
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0016
1243	Cathepsin D	CTSD	0.0016
1010	Cytochrome P450 51A1	CYP51A1	0.0016
373	Transthyretin	TTR	0.0016
474	Acetylcholinesterase	ACHE	0.0016
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0016
427	Substance-P receptor	TACR1	0.0016
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0016
921	Glutamate receptor 2	GRIA2	0.0015
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0015
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0015
6031	Cytochrome P450 3A43	CYP3A43	0.0015
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0015
70	Type-1 angiotensin II receptor	AGTR1	0.0015
2499	Tubulin beta-2C chain	TUBB2C	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
6432	Transporter	snf	0.0015
6102	Arylamine N-acetyltransferase 2	NAT2	0.0014
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0014
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0014
2091	Endoplasmin	HSP90B1	0.0014
6859	Protein S100-A4	S100A4	0.0014
904	Glutathione S-transferase P	GSTP1	0.0014
2449	Tubulin alpha-3 chain	TUBA1A	0.0014
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0013
543	Penicillin-binding protein 1B	mrcB	0.0013
6186	Penicillin-binding protein 1B	ponB	0.0013
6822	Penicillin-binding protein 1b	pbp1b	0.0013
6844	Penicillin-binding protein 1b	pbp1b	0.0013
380	Cytochrome P450 17A1	CYP17A1	0.0013
844	Epidermal growth factor receptor	EGFR	0.0013
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0013
756	Sex hormone-binding globulin	SHBG	0.0013
645	Penicillin-binding protein 1A	mrcA	0.0013
5805	Penicillin-binding protein 1A	ponA	0.0013
6185	Penicillin-binding protein 1A	mrcA	0.0013
6799	Penicillin-binding protein 1A	pbpA	0.0013
159	Penicillin-binding protein 2B	penA	0.0013
6121	Penicillin-binding protein 2B	penA	0.0013
696	Kappa-type opioid receptor	OPRK1	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
1024	Solute carrier family 22 member 11	SLC22A11	0.0013
6146	High affinity copper uptake protein 1	SLC31A1	0.0012
4311	tRNA	TRDMT1	0.0012
4325	tRNA	trmD	0.0012
4328	tRNA	trmD	0.0012
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0012
518	Peroxidase/catalase T	katG	0.0012
1629	Transcription factor AP-1	JUN	0.0012
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0011
828	Phenylalanine-4-hydroxylase	PAH	0.0011
3109	Phenylalanine-4-hydroxylase	phhA	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
6043	Putative G-protein coupled receptor 44	GPR44	0.0011
563	Thyroid peroxidase	TPO	0.0011
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0011
4192	DNA topoisomerase 2-beta	TOP2B	0.0011
467	Delta-type opioid receptor	OPRD1	0.0011
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.001
634	Squalene monooxygenase	SQLE	0.001
7196	Squalene monooxygenase	ERG1	0.001
239	Coagulation factor X	F10	0.001
4237	50S ribosomal protein L22	rplV	0.001
6136	Multidrug resistance-associated protein 5	ABCC5	0.001
1714	Mitogen-activated protein kinase 3	MAPK3	0.001
4604	Liver carboxylesterase 1	CES1	0.001
564	Cellular retinoic acid-binding protein 1	CRABP1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
908	Glutathione S-transferase theta-1	GSTT1	0.001
1192	Sulfotransferase 1A1	SULT1A1	0.001
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.001
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.001
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.001
859	Cellular retinoic acid-binding protein 2	CRABP2	0.001
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.001
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.001
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.001
823	Fibroblast growth factor receptor 2	FGFR2	0.001
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
6137	Multidrug resistance-associated protein 6	ABCC6	0.0009
6182	Cytochrome P450 2J2	CYP2J2	0.0009
780	Retinoic acid receptor RXR-gamma	RXRG	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0009
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0009
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0009
365	Dihydrofolate reductase	DHFR	0.0009
2381	Dihydrofolate reductase	DFR1	0.0009
2833	Dihydrofolate reductase	Not Available	0.0009
2931	Dihydrofolate reductase	folA	0.0009
3544	Dihydrofolate reductase	folA	0.0009
3682	Dihydrofolate reductase	folA	0.0009
6642	Dihydrofolate reductase	folA	0.0009
6756	Dihydrofolate reductase	dfrA	0.0009
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0009
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0009
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0009
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0008
88	Retinoic acid receptor RXR-beta	RXRB	0.0008
2236	Casein kinase II subunit alpha	CSNK2A1	0.0008
3830	Calreticulin	CALR	0.0008
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0008
162	Retinoic acid receptor gamma-1	RARG	0.0008
6167	Organic solute transporter subunit beta	OSTB	0.0008
6166	Organic solute transporter subunit alpha	OSTA	0.0008
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0008
146	Androgen receptor	AR	0.0008
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0008
1618	High affinity nerve growth factor receptor	NTRK1	0.0008
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0008
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0008
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0008
6034	Hydroxyindole O-methyltransferase	ASMT	0.0008
6035	Nuclear receptor ROR-beta	RORB	0.0008
6036	Eosinophil peroxidase	EPX	0.0008
811	Translocator protein	TSPO	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
976	Platelet glycoprotein IX	GP9	0.0008
1374	Natriuretic peptides B	NPPB	0.0008
1827	Gap junction alpha-1 protein	GJA1	0.0008
1908	Vascular cell adhesion protein 1	VCAM1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
4103	Proteasome subunit beta type 2	PSMB2	0.0007
4102	Proteasome subunit beta type 5	PSMB5	0.0007
4101	Proteasome subunit beta type 1	PSMB1	0.0007
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0007
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
3810	Catechol O-methyltransferase	COMT	0.0007
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0007
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0007
814	Ryanodine receptor 1	RYR1	0.0007
822	Aldose reductase	AKR1B1	0.0007
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0007
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0007
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0007
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
251	Alcohol dehydrogenase 1A	ADH1A	0.0007
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
705	Glutamate receptor 1	GRIA1	0.0007
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0007
6141	Sodium/bile acid cotransporter	SLC10A1	0.0007
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0006
820	Glycine receptor subunit alpha-2	GLRA2	0.0006
268	Adenosine A2b receptor	ADORA2B	0.0006
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0006
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0006
484	Tyrosine-protein kinase ABL2	ABL2	0.0006
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0006
444	Alcohol dehydrogenase 1B	ADH1B	0.0006
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0006
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0006
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0006
183	Vascular endothelial growth factor A	VEGFA	0.0006
6163	Copper-transporting ATPase 2	ATP7B	0.0006
6165	Copper-transporting ATPase 1	ATP7A	0.0006
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
1864	RET proto-oncogene	RET	0.0006
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0006
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0006
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0006
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0006
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0006
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0006
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0006
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0006
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0006
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0006
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0006
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0005
1275	Estrogen sulfotransferase	SULT1E1	0.0005
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0005
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0005
153	Dopamine beta-hydroxylase	DBH	0.0005
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0005
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0005
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0005
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0005
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0005
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
517	Alcohol dehydrogenase 1C	ADH1C	0.0005
798	Osteocalcin	BGLAP	0.0005
5934	Cytochrome P450 26A1	CYP26A1	0.0005
1050	Bile salt sulfotransferase	SULT2A1	0.0005
751	Potassium channel subfamily K member 6	KCNK6	0.0005
1039	Histone deacetylase 9	HDAC9	0.0005
4120	NADPH--cytochrome P450 reductase	POR	0.0005
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0005
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0005
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0005
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
896	Glutathione S-transferase Mu 1	GSTM1	0.0005
3937	Fatty-acid amide hydrolase	FAAH	0.0005
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0005
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0005
172	Potassium channel subfamily K member 1	KCNK1	0.0005
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0005
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0004
6149	Solute carrier family 22 member 10	SLC22A10	0.0004
165	FL cytokine receptor	FLT3	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0004
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0004
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0004
24	Thymidylate synthase	TMP1	0.0004
359	Thymidylate synthase	TYMS	0.0004
2626	Thymidylate synthase	thyA	0.0004
2729	Thymidylate synthase	thyA	0.0004
5352	Thymidylate synthase	THYA	0.0004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0004
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0004
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0004
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0004
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0004
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0004
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0004
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0004
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0004
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0004
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0004
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0004
737	Mineralocorticoid receptor	NR3C2	0.0004
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0004
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0004
295	Carbonic anhydrase 1	CA1	0.0004
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0004
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0004
614	Progesterone receptor	PGR	0.0003
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0003
6085	Fatty acid-binding protein, intestinal	FABP2	0.0003
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0003
54	Prothrombin	F2	0.0003
738	Monocarboxylate transporter 1	SLC16A1	0.0003
7	Nitric oxide synthase, inducible	NOS2	0.0003
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0003
291	Nitric-oxide synthase, endothelial	NOS3	0.0003
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0002
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00998 - Frovatriptan

Targets

Enzymes

Predictions