DT-Web: DB01104

Identification

Name

Sertraline

Accession Number

DB01104 (APRD00175)

Type

small molecule

Description

Sertraline hydrochloride belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D₂ or histamine H₁ receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT_1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT_1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache (see Toxicity section below for a more detailed listing of side effects). Compared to other agents in this class, sertraline may cause greater diarrheal and male sexual dysfunction effects. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Sertraline may be used to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD) and social anxiety disorder (social phobia).

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

306.23

Groups

approved

Monoisotopic Weight

305.073804963

Pharmacology

Indication

For the management of major depressive disorder, posttraumatic stress disorder, obsessive-compulsive disorder, panic disorder with or without agoraphobia, premenstrual dysphoric disorder, social phobia, premature ejaculation, and vascular headaches.

Mechanism of action

The exact mechanism of action sertraline is not fully known, but the drug appears to selectively inhibit the reuptake of serotonin at the presynaptic membrane. This results in an increased synaptic concentration of serotonin in the CNS, which leads to numerous functional changes associated with enhanced serotonergic neurotransmission. It is suggested that these modifications are responsible for the antidepressant action observed during long term administration of antidepressants. It has also been hypothesized that obsessive-compulsive disorder is caused by the dysregulation of serotonin, as it is treated by sertraline, and the drug corrects this imbalance.

Absorption

The effects of food on the bioavailability of the sertraline tablet and oral concentrate were studied in subjects administered a single dose with and without food. For the tablet, AUC was slightly increased when drug was administered with food but the Cmax was 25% greater, while the time to reach peak plasma concentration (Tmax) decreased from 8 hours post-dosing to 5.5 hours. For the oral concentrate, Tmax was slightly prolonged from 5.9 hours to 7.0 hours with food.

Protein binding

98% bound to serum proteins, principally to albumin and α₁-acid glycoprotein

Biotransformation

Extensively metabolized in the liver. Sertraline metabolism involves N-demethylation, N-hydroxylation, oxidative deamination, and glucuronidation of sertraline carbamic acid. Sertraline undergoes N-demethylation primarily catalyzed by cytochrome P450 (CYP) 2B6, with CYP2C19, CYP3A4 and CYP2D6 contributing to a lesser extent. Deamination occurs via CYP3A4 and CYP2C19. In vitro studies have shown that monoamine oxidase A and B may also catalyze sertraline deamination. Sertraline N-carbamoyl glucuronidation has also been observed in human liver microsomes.

Route of elimination

Sertraline is extensively metabolized and excretion of unchanged drug in urine is a minor route of elimination.

Toxicity

Symptoms of toxicity include alopecia, decreased libido, diarrhea, ejaculation disorder, fatigue, insomnia, somnolence and serotonin syndrome. The most frequently observed side effects include: GI effects such as nausea, diarrhea or loose stools, dyspepsia, and dry mouth; nervous system effects such as somnolence, dizziness, insomnia, and tremor; sexual dysfunction in males (principally ejaculatory delay); and sweating.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Almotriptan	Increased risk of CNS adverse effects
Carbamazepine	Sertraline increases the effect of carbamazepine
Carvedilol	The SSRI, sertraline, may increase the bradycardic effect of the beta-blocker, carvedilol.
Cilostazol	Sertraline increases the effect of cilostazol
Clarithromycin	Possible serotoninergic syndrome with this combination
Clozapine	The antidepressant increases the effect of clozapine
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Donepezil	Possible antagonism of action
Eletriptan	Increased risk of CNS adverse effects
Erythromycin	Possible serotoninergic syndrome with this combination
Fosphenytoin	Sertraline increases the effect of hydantoin
Frovatriptan	Increased risk of CNS adverse effects
Galantamine	Possible antagonism of action
Ginkgo biloba	Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Isocarboxazid	Possible severe adverse reaction with this combination
Ketoprofen	Concomitant therapy may result in additive antiplatelet effects and increase the risk of bleeding. Monitor for increased risk of bleeding during concomitant therapy.
Linezolid	Combination associated with possible serotoninergic syndrome
Metoprolol	The SSRI increases the effect of the beta-blocker
Moclobemide	Possible severe adverse reaction with this combination
Naratriptan	Increased risk of CNS adverse effects
Oxycodone	Increased risk of serotonin syndrome
Phenelzine	Possible severe adverse reaction with this combination
Phenytoin	Sertraline increases the effect of hydantoin
Pimozide	The SSRI, sertraline, increases the effect and toxicity of pimozide.
Propafenone	Fluoxetine increases the effect and toxicity of propafenone
Propranolol	The SSRI, sertraline, may increase the bradycardic effect of the beta-blocker, propranolol.
Rasagiline	Possible severe adverse reaction with this combination
Tamoxifen	Sertraline may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin	Sertraline, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Sertraline is initiated, discontinued, or dose changed.
Terbinafine	Terbinafine may reduce the metabolism and clearance of Sertraline. Consider alternate therapy or monitor for therapeutic/adverse effects of Sertraline if Terbinafine is initiated, discontinued or dose changed.
Tiaprofenic acid	Additive antiplatelet effects increase the risk of bleeding. Consider alternate therapy or monitor for increased bleeding.
Tipranavir	Tipranavir increases the concentration of Sertraline. The Sertraline dose may require an adjustment.
Tolmetin	Increased antiplatelet effects may enhance the risk of bleeding. Alternate therapy may be considered or monitor for inreased bleeding during concomitant therapy.
Tolterodine	Sertraline may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tramadol	Tramadol increases the risk of serotonin syndrome and seizures. Sertraline may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Sertraline may decrease the effect of Tramadol by decreasing active metabolite production.
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Treprostinil	The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Sertraline. Monitor for increased bleeding during concomitant thearpy.
Trimipramine	The SSRI, Sertraline, may decrease the metabolism and clearance of Trimipramine. Increased risk of serotonin syndrome. Monitor for changes in Trimipramine efficacy and toxicity if Sertraline is initiated, discontinued or dose changed.
Triprolidine	The CNS depressants, Triprolidine and Sertraline, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and sertraline, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.

Food Interactions

Take with food.
Avoid St.John's Wort.
Avoid alcohol.
Avoid taking with grapefruit juice.

Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	yes
Actions	inhibitor
References	Benmansour S, Cecchi M, Morilak DA, Gerhardt GA, Javors MA, Gould GG, Frazer A: Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. J Neurosci. 1999 Dec 1;19(23):10494-501. - Pubmed Benmansour S, Owens WA, Cecchi M, Morilak DA, Frazer A: Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter. J Neurosci. 2002 Aug 1;22(15):6766-72. - Pubmed Borkowska A, Pilaczynska E, Araszkiewicz A, Rybakowski J: [The effect of sertraline on cognitive functions in patients with obsessive-compulsive disorder] Psychiatr Pol. 2002 Nov-Dec;36(6 Suppl):289-95. - Pubmed Durham LK, Webb SM, Milos PM, Clary CM, Seymour AB: The serotonin transporter polymorphism, 5HTTLPR, is associated with a faster response time to sertraline in an elderly population with major depressive disorder. Psychopharmacology (Berl). 2004 Aug;174(4):525-9. Epub 2003 Sep 4. - Pubmed Chen F, Larsen MB, Neubauer HA, Sanchez C, Plenge P, Wiborg O: Characterization of an allosteric citalopram-binding site at the serotonin transporter. J Neurochem. 2005 Jan;92(1):21-8. - Pubmed Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed David DJ, Bourin M, Hascoet M, Colombel MC, Baker GB, Jolliet P: Comparison of antidepressant activity in 4- and 40-week-old male mice in the forced swimming test: involvement of 5-HT1A and 5-HT1B receptors in old mice. Psychopharmacology (Berl). 2001 Feb;153(4):443-9. - Pubmed Rogoz Z, Skuza G: Mechanism of synergistic action following co-treatment with pramipexole and fluoxetine or sertraline in the forced swimming test in rats. Pharmacol Rep. 2006 Jul-Aug;58(4):493-500. - Pubmed Muneoka K, Shirayama Y, Takigawa M, Shioda S: Brain region-specific effects of short-term treatment with duloxetine, venlafaxine, milnacipran and sertraline on monoamine metabolism in rats. Neurochem Res. 2009 Mar;34(3):542-55. Epub 2008 Aug 27. - Pubmed Iehle C, Delos S, Filhol O, Martin PM: Baculovirus-directed expression of human prostatic steroid 5 alpha-reductase 1 in an active form. J Steroid Biochem Mol Biol. 1993 Aug;46(2):177-82. - Pubmed
DTHybrid score	0.468
Sodium-dependent dopamine transporter
Name	Sodium-dependent dopamine transporter
Gene Name	SLC6A3
Pharmacological action	unknown
Actions	inhibitor
References	Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed Ghanizadeh A: Sertraline-associated hair loss. J Drugs Dermatol. 2008 Jul;7(7):693-4. - Pubmed Lemke MR: [Antidepressant effects of dopamine agonists. Experimental and clinical findings] Nervenarzt. 2007 Jan;78(1):31-8. - Pubmed Nemeroff CB, Owens MJ: Pharmacologic differences among the SSRIs: focus on monoamine transporters and the HPA axis. CNS Spectr. 2004 Jun;9(6 Suppl 4):23-31. - Pubmed Goodnick PJ, Goldstein BJ: Selective serotonin reuptake inhibitors in affective disorders--I. Basic pharmacology. J Psychopharmacol. 1998;12(3 Suppl B):S5-20. - Pubmed
DTHybrid score	0.5518

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Micallef J, Fakra E, Blin O: [Use of antidepressant drugs in schizophrenic patients with depression] Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9. - Pubmed Rojdmark S, von Bahr C: [Metabolic interaction between psychopharmaceuticals. Probable cause of exacerbation of hypothyroidism according to a case report] Lakartidningen. 2002 Jun 20;99(25):2854-6. - Pubmed DeVane CL, Donovan JL, Liston HL, Markowitz JS, Cheng KT, Risch SC, Willard L: Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers. J Clin Psychopharmacol. 2004 Feb;24(1):4-10. - Pubmed Obach RS, Cox LM, Tremaine LM: Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. Drug Metab Dispos. 2005 Feb;33(2):262-70. Epub 2004 Nov 16. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7768
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Baumann P: Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996 Dec;31(6):444-69. - Pubmed Micallef J, Fakra E, Blin O: [Use of antidepressant drugs in schizophrenic patients with depression] Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9. - Pubmed Rojdmark S, von Bahr C: [Metabolic interaction between psychopharmaceuticals. Probable cause of exacerbation of hypothyroidism according to a case report] Lakartidningen. 2002 Jun 20;99(25):2854-6. - Pubmed Obach RS, Cox LM, Tremaine LM: Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. Drug Metab Dispos. 2005 Feb;33(2):262-70. Epub 2004 Nov 16. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.69
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Micallef J, Fakra E, Blin O: [Use of antidepressant drugs in schizophrenic patients with depression] Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9. - Pubmed Rojdmark S, von Bahr C: [Metabolic interaction between psychopharmaceuticals. Probable cause of exacerbation of hypothyroidism according to a case report] Lakartidningen. 2002 Jun 20;99(25):2854-6. - Pubmed Obach RS, Cox LM, Tremaine LM: Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. Drug Metab Dispos. 2005 Feb;33(2):262-70. Epub 2004 Nov 16. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5295
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Obach RS, Cox LM, Tremaine LM: Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. Drug Metab Dispos. 2005 Feb;33(2):262-70. Epub 2004 Nov 16. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.562
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate,inhibitor
References	Obach RS, Cox LM, Tremaine LM: Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. Drug Metab Dispos. 2005 Feb;33(2):262-70. Epub 2004 Nov 16. - Pubmed Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3973
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5553
Amine oxidase [flavin-containing] B
Name	Amine oxidase [flavin-containing] B
Gene Name	MAOB
Actions	substrate
References	Obach RS, Cox LM, Tremaine LM: Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. Drug Metab Dispos. 2005 Feb;33(2):262-70. Epub 2004 Nov 16. - Pubmed
DTHybrid score	1.0405
Amine oxidase [flavin-containing] A
Name	Amine oxidase [flavin-containing] A
Gene Name	MAOA
Actions	substrate
References	Obach RS, Cox LM, Tremaine LM: Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. Drug Metab Dispos. 2005 Feb;33(2):262-70. Epub 2004 Nov 16. - Pubmed
DTHybrid score	0.6516
CYP2B protein
Name	CYP2B protein
Gene Name	CYP2B
Actions	inhibitor
References	Haduch A, Wojcikowski J, Daniel WA: Effect of selected antidepressant drugs on cytochrome P450 2B (CYP2B) in rat liver. An in vitro and in vivo study. Pharmacol Rep. 2008 Nov-Dec;60(6):957-65. - Pubmed
DTHybrid score	0.2681

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Weiss J, Dormann SM, Martin-Facklam M, Kerpen CJ, Ketabi-Kiyanvash N, Haefeli WE: Inhibition of P-glycoprotein by newer antidepressants. J Pharmacol Exp Ther. 2003 Apr;305(1):197-204. - Pubmed
DTHybrid score	0.489

Id	Partner name	Gene Name	Score
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.3751
4924	Cytochrome P450 2C8	CYP2C8	0.2847
4118	Cytochrome P450 3A5	CYP3A5	0.2632
6013	Cytochrome P450 2E1	CYP2E1	0.2052
6107	Cytochrome P450 3A7	CYP3A7	0.1866
492	Histamine H1 receptor	HRH1	0.1755
5718	Cytochrome P450 2A6	CYP2A6	0.1404
6024	Cytochrome P450 1A1	CYP1A1	0.1372
556	Alpha-1A adrenergic receptor	ADRA1A	0.1311
103	Muscarinic acetylcholine receptor M1	CHRM1	0.123
587	Serum albumin	ALB	0.1173
502	5-hydroxytryptamine 2A receptor	HTR2A	0.1152
318	Alpha-2A adrenergic receptor	ADRA2A	0.1143
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1081
131	Synaptic vesicular amine transporter	SLC18A2	0.1054
1181	Alpha-1-acid glycoprotein 1	ORM1	0.105
20	Prostaglandin G/H synthase 1	PTGS1	0.0937
3811	Cytochrome P450 19A1	CYP19A1	0.0915
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0877
632	Alpha-1B adrenergic receptor	ADRA1B	0.0842
320	5-hydroxytryptamine 1A receptor	HTR1A	0.077
831	D(2) dopamine receptor	DRD2	0.0769
6106	Cytochrome P450 2C18	CYP2C18	0.0747
290	Prostaglandin G/H synthase 2	PTGS2	0.0704
6145	Solute carrier family 22 member 1	SLC22A1	0.0688
193	Beta-1 adrenergic receptor	ADRB1	0.0668
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0668
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0646
766	Beta-2 adrenergic receptor	ADRB2	0.064
6144	Solute carrier family 22 member 2	SLC22A2	0.0639
3923	Cholinesterase	BCHE	0.0604
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0603
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0595
23	D(1A) dopamine receptor	DRD1	0.0579
862	Multidrug resistance-associated protein 1	ABCC1	0.0562
118	Organic cation/carnitine transporter 2	SLC22A5	0.0557
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0525
1729	Solute carrier family 22 member 6	SLC22A6	0.0516
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0488
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0474
436	5-hydroxytryptamine 2B receptor	HTR2B	0.047
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0465
629	Alpha-2B adrenergic receptor	ADRA2B	0.0464
6147	Solute carrier family 22 member 3	SLC22A3	0.0463
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0459
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0452
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0432
1898	Cytochrome P450 1B1	CYP1B1	0.043
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.041
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0407
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0405
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0401
847	Mu-type opioid receptor	OPRM1	0.0397
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0394
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.039
378	Alpha-2C adrenergic receptor	ADRA2C	0.0389
3947	Xanthine dehydrogenase/oxidase	XDH	0.0388
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0384
731	HIV-1 protease	HIV-1 protease	0.0384
3810	Catechol O-methyltransferase	COMT	0.0383
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0376
136	Estrogen receptor	ESR1	0.0373
789	Alpha-1D adrenergic receptor	ADRA1D	0.0362
146	Androgen receptor	AR	0.0357
467	Delta-type opioid receptor	OPRD1	0.0347
776	Bile salt export pump	ABCB11	0.0343
1636	Trace amine-associated receptor 1	TAAR1	0.0337
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0335
696	Kappa-type opioid receptor	OPRK1	0.0332
871	Glucocorticoid receptor	NR3C1	0.032
260	Cytochrome P450 51	ERG11	0.0316
761	Cytochrome P450 51	ERG11	0.0316
3163	Cytochrome P450 51	cyp51	0.0316
6142	Solute carrier family 22 member 8	SLC22A8	0.0302
638	D(3) dopamine receptor	DRD3	0.0299
465	Calmodulin	CALM1	0.0296
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0294
817	DNA topoisomerase 2-alpha	TOP2A	0.0289
1757	Myeloperoxidase	MPO	0.0287
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0285
833	Organic cation/carnitine transporter 1	SLC22A4	0.0276
122	P2Y purinoceptor 12	P2RY12	0.027
2164	Multidrug resistance-associated protein 4	ABCC4	0.0264
6143	Solute carrier family 22 member 7	SLC22A7	0.0262
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0261
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.026
36	Insulin receptor	INSR	0.0258
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0257
6031	Cytochrome P450 3A43	CYP3A43	0.0256
468	Cytochrome P450 4A11	CYP4A11	0.0246
6182	Cytochrome P450 2J2	CYP2J2	0.0242
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0239
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0237
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0236
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0236
2864	Penton protein	PIII	0.0236
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0232
4120	NADPH--cytochrome P450 reductase	POR	0.0231
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0228
432	D(4) dopamine receptor	DRD4	0.0223
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0216
273	Apoptosis regulator Bcl-2	BCL2	0.0216
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0215
1517	Beta-3 adrenergic receptor	ADRB3	0.0208
474	Acetylcholinesterase	ACHE	0.0208
5841	Insulin-like growth factor IB	IGF1	0.0206
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0199
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0199
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0195
124	Histamine H2 receptor	HRH2	0.0187
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0186
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0185
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0182
891	Dihydropteroate synthase	folP	0.0182
5359	Dihydropteroate synthase	folP	0.0182
7175	Dihydropteroate synthase	sulI	0.0182
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0182
477	DNA topoisomerase 4 subunit A	parC	0.0181
886	DNA topoisomerase 4 subunit A	parC	0.0181
6226	DNA topoisomerase 4 subunit A	parC	0.0181
404	DNA gyrase subunit A	gyrA	0.0178
6224	DNA gyrase subunit A	gyrA	0.0178
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0176
163	D(1B) dopamine receptor	DRD5	0.0174
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0174
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0174
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0173
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0171
6014	Cytochrome P450 2A13	CYP2A13	0.0169
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0169
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0166
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0166
4604	Liver carboxylesterase 1	CES1	0.0165
70	Type-1 angiotensin II receptor	AGTR1	0.0162
818	50S ribosomal protein L10	rplJ	0.016
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.016
6220	Aryl hydrocarbon receptor	AHR	0.0159
504	Mast/stem cell growth factor receptor	KIT	0.0158
6137	Multidrug resistance-associated protein 6	ABCC6	0.0153
844	Epidermal growth factor receptor	EGFR	0.015
6148	Multidrug resistance-associated protein 7	ABCC10	0.0149
777	Tumor necrosis factor	TNF	0.0148
94	5-hydroxytryptamine 4 receptor	HTR4	0.0148
614	Progesterone receptor	PGR	0.0145
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0143
1024	Solute carrier family 22 member 11	SLC22A11	0.0142
756	Sex hormone-binding globulin	SHBG	0.0141
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.014
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.014
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0139
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0139
161	Tubulin beta chain	TUBB	0.0139
312	Tubulin beta chain	TUB2	0.0139
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0139
174	Sigma 1-type opioid receptor	SIGMAR1	0.0139
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0138
6136	Multidrug resistance-associated protein 5	ABCC5	0.0138
716	5-hydroxytryptamine 7 receptor	HTR7	0.0137
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0137
869	Estrogen receptor beta	ESR2	0.0134
6432	Transporter	snf	0.0133
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0133
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0132
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0132
380	Cytochrome P450 17A1	CYP17A1	0.0129
407	Vascular endothelial growth factor receptor 2	KDR	0.0128
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0128
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0128
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0128
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0128
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0127
6141	Sodium/bile acid cotransporter	SLC10A1	0.0125
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0125
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0124
26	Vascular endothelial growth factor receptor 3	FLT4	0.0124
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0124
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0123
571	Melatonin receptor type 1A	MTNR1A	0.0122
362	Melatonin receptor type 1B	MTNR1B	0.0122
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0119
32	Vascular endothelial growth factor receptor 1	FLT1	0.0118
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0118
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0118
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0118
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0118
592	Carbonic anhydrase 4	CA4	0.0117
153	Dopamine beta-hydroxylase	DBH	0.0117
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0117
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0117
295	Carbonic anhydrase 1	CA1	0.0115
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0115
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0115
811	Translocator protein	TSPO	0.0115
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0113
1010	Cytochrome P450 51A1	CYP51A1	0.0113
482	Glycine receptor subunit alpha-1	GLRA1	0.0113
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0112
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0112
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0111
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.011
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.011
1483	Membrane copper amine oxidase	AOC3	0.0109
952	Dipeptidyl peptidase 4	DPP4	0.0108
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0106
1178	Adenosine A2a receptor	ADORA2A	0.0106
427	Substance-P receptor	TACR1	0.0106
5698	Riboflavin synthase alpha chain	ribE	0.0105
373	Transthyretin	TTR	0.0104
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0103
232	Corticosteroid-binding globulin	SERPINA6	0.0103
16	Adenosine A1 receptor	ADORA1	0.0102
408	Riboflavin kinase	RFK	0.0101
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.01
1192	Sulfotransferase 1A1	SULT1A1	0.0099
6020	Aldehyde oxidase	AOX1	0.0099
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0099
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0099
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
319	Opioid receptor, sigma 1	OPRS1	0.0096
49	Endothelin B receptor	EDNRB	0.0096
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0095
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0094
365	Dihydrofolate reductase	DHFR	0.0094
2381	Dihydrofolate reductase	DFR1	0.0094
2833	Dihydrofolate reductase	Not Available	0.0094
2931	Dihydrofolate reductase	folA	0.0094
3544	Dihydrofolate reductase	folA	0.0094
3682	Dihydrofolate reductase	folA	0.0094
6642	Dihydrofolate reductase	folA	0.0094
6756	Dihydrofolate reductase	dfrA	0.0094
3913	Glutamic acid decarboxylase	GAD65	0.0094
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0094
6102	Arylamine N-acetyltransferase 2	NAT2	0.0092
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0092
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0092
29	Tubulin beta-1 chain	TUBB1	0.0092
578	Endothelin-1 receptor	EDNRA	0.009
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.009
357	Carbonic anhydrase 2	CA2	0.0089
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0089
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0089
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
921	Glutamate receptor 2	GRIA2	0.0087
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0086
6126	Carbonic anhydrase 7	CA7	0.0086
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0084
1618	High affinity nerve growth factor receptor	NTRK1	0.0083
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0083
705	Glutamate receptor 1	GRIA1	0.0082
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0082
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0081
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0081
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0081
904	Glutathione S-transferase P	GSTP1	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
1256	5-hydroxytryptamine 6 receptor	HTR6	0.008
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.008
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0079
173	Toll-like receptor 7	TLR7	0.0079
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0078
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0078
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0078
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0077
735	Alanine aminotransferase 1	GPT	0.0077
3904	Alanine aminotransferase 2	GPT2	0.0077
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0077
244	Angiotensin-converting enzyme	ACE	0.0076
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0076
2449	Tubulin alpha-3 chain	TUBA1A	0.0076
6085	Fatty acid-binding protein, intestinal	FABP2	0.0076
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0076
4122	Histone deacetylase 2	HDAC2	0.0075
654	Flavin reductase	BLVRB	0.0075
738	Monocarboxylate transporter 1	SLC16A1	0.0075
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0074
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0074
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0074
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0073
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0073
4237	50S ribosomal protein L22	rplV	0.0073
1353	DNA topoisomerase 1	TOP1	0.0072
3552	DNA topoisomerase 1	topA	0.0072
4116	Dihydropteroate synthetase	Not Available	0.0072
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0072
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0072
183	Vascular endothelial growth factor A	VEGFA	0.0072
6138	Multidrug resistance protein 3	ABCB4	0.0072
694	Matrix protein 2	M	0.0071
737	Mineralocorticoid receptor	NR3C2	0.0071
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0071
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.007
275	Arachidonate 5-lipoxygenase	ALOX5	0.0069
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0069
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0069
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0069
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0069
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0068
68	Cannabinoid receptor 1	CNR1	0.0068
563	Thyroid peroxidase	TPO	0.0067
1629	Transcription factor AP-1	JUN	0.0067
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0067
284	DNA-directed RNA polymerase beta chain	rpoB	0.0065
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0065
2499	Tubulin beta-2C chain	TUBB2C	0.0065
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0064
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
856	Vitamin D3 receptor	VDR	0.0063
823	Fibroblast growth factor receptor 2	FGFR2	0.0063
133	Dihydropterate synthase	sulI	0.0063
2112	Toll-like receptor 9	TLR9	0.0062
4203	Histamine N-methyltransferase	HNMT	0.0061
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.006
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.006
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
2539	Tubulin alpha-1 chain	TUBA4A	0.0059
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0059
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0059
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0059
814	Ryanodine receptor 1	RYR1	0.0059
780	Retinoic acid receptor RXR-gamma	RXRG	0.0059
24	Thymidylate synthase	TMP1	0.0058
359	Thymidylate synthase	TYMS	0.0058
2626	Thymidylate synthase	thyA	0.0058
2729	Thymidylate synthase	thyA	0.0058
5352	Thymidylate synthase	THYA	0.0058
4238	50S ribosomal protein L4	rplD	0.0058
5578	50S ribosomal protein L4	rplD	0.0058
6173	50S ribosomal protein L4	rplD	0.0058
6219	50S ribosomal protein L4	rplD	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0058
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0058
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0058
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0057
4103	Proteasome subunit beta type 2	PSMB2	0.0057
4102	Proteasome subunit beta type 5	PSMB5	0.0056
4101	Proteasome subunit beta type 1	PSMB1	0.0056
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0056
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0056
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0056
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0056
3932	Glutathione S-transferase A2	GSTA2	0.0055
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0055
518	Peroxidase/catalase T	katG	0.0055
6506	Stathmin-4	STMN4	0.0055
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0055
239	Coagulation factor X	F10	0.0054
581	Cytochrome P450 2R1	CYP2R1	0.0054
6044	Serum paraoxonase/lactonase 3	PON3	0.0054
992	Protein tyrosine kinase 2 beta	PTK2B	0.0054
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0054
88	Retinoic acid receptor RXR-beta	RXRB	0.0053
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0053
1275	Estrogen sulfotransferase	SULT1E1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
165	FL cytokine receptor	FLT3	0.0053
6043	Putative G-protein coupled receptor 44	GPR44	0.0053
714	Glutathione reductase, mitochondrial	GSR	0.0052
712	Tubulin alpha chain	TUB1	0.0052
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0052
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0051
6146	High affinity copper uptake protein 1	SLC31A1	0.0051
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0049
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0049
54	Prothrombin	F2	0.0048
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0048
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0048
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
5300	Antigen peptide transporter 1	TAP1	0.0047
4311	tRNA	TRDMT1	0.0047
4325	tRNA	trmD	0.0047
4328	tRNA	trmD	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
7	Nitric oxide synthase, inducible	NOS2	0.0047
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0047
683	Potassium transporter	GK0582	0.0047
1852	Microtubule-associated protein 2	MAP2	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
634	Squalene monooxygenase	SQLE	0.0046
7196	Squalene monooxygenase	ERG1	0.0046
1050	Bile salt sulfotransferase	SULT2A1	0.0046
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0045
1630	Integrin beta-2	ITGB2	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
6134	Sodium channel subunit beta-3	SCN3B	0.0045
6133	Sodium channel subunit beta-2	SCN2B	0.0045
6132	Sodium channel subunit beta-1	SCN1B	0.0045
6135	Sodium channel subunit beta-4	SCN4B	0.0045
6127	Carbonic anhydrase-related protein	CA8	0.0045
6129	Carbonic anhydrase-related protein 11	CA11	0.0045
6128	Carbonic anhydrase-related protein 10	CA10	0.0045
6131	Carbonic anhydrase 14	CA14	0.0045
130	Prostacyclin synthase	PTGIS	0.0044
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0044
84	Nuclear receptor 0B1	NR0B1	0.0044
117	Sterol O-acyltransferase 1	SOAT1	0.0043
6122	Carbonic anhydrase 3	CA3	0.0043
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0042
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0042
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0042
3957	Adenosine deaminase	ADA	0.0042
6130	Carbonic anhydrase 13	CA13	0.0042
1992	Vitamin D-binding protein	GC	0.0042
768	FK506-binding protein 1A	FKBP1A	0.0042
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0041
1648	Elastin	ELN	0.0041
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
106	Cannabinoid receptor 2	CNR2	0.004
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
976	Platelet glycoprotein IX	GP9	0.004
5787	Angiopoietin-1 receptor	TEK	0.004
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.004
6174	50S ribosomal protein L32	rpmF	0.004
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.004
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.004
6149	Solute carrier family 22 member 10	SLC22A10	0.004
1262	Corticotropin-lipotropin	POMC	0.004
3856	Fibroblast growth factor receptor 3	FGFR3	0.0039
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0039
1541	Metalloproteinase	mmp20	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
936	Ephrin type-A receptor 2	EPHA2	0.0038
85	Growth hormone receptor	GHR	0.0038
164	Histamine H4 receptor	HRH4	0.0038
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0037
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
3809	Estrogen-related receptor gamma	ESRRG	0.0037
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0037
33	Cystine/glutamate transporter	SLC7A11	0.0037
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0037
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0036
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0036
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0036
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0036
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0036
469	Annexin A1	ANXA1	0.0036
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0036
4773	Deoxycytidine kinase	DCK	0.0036
251	Alcohol dehydrogenase 1A	ADH1A	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0035
444	Alcohol dehydrogenase 1B	ADH1B	0.0035
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0035
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0035
5934	Cytochrome P450 26A1	CYP26A1	0.0035
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0035
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0035
2300	Lysozyme	E	0.0035
3633	Lysozyme	R	0.0035
5597	Lysozyme	17	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0035
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
6766	O-GlcNAcase BT_4395	BT_4395	0.0034
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0034
820	Glycine receptor subunit alpha-2	GLRA2	0.0034
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0034
558	Solute carrier family 12 member 1	SLC12A1	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0033
4205	Carbonic anhydrase 9	CA9	0.0033
3007	Carbonic anhydrase 12	CA12	0.0033
65	Matrix metalloproteinase-9	Not Available	0.0033
327	Glutathione reductase	gor	0.0033
5110	Glutathione reductase	GR2	0.0033
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0032
3937	Fatty-acid amide hydrolase	FAAH	0.0032
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
1374	Natriuretic peptides B	NPPB	0.0031
1827	Gap junction alpha-1 protein	GJA1	0.0031
1908	Vascular cell adhesion protein 1	VCAM1	0.0031
908	Glutathione S-transferase theta-1	GSTT1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
6824	Tyrosine-protein kinase Lyn	LYN	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.003
291	Nitric-oxide synthase, endothelial	NOS3	0.003
5798	Mitogen-activated protein kinase 11	MAPK11	0.003
517	Alcohol dehydrogenase 1C	ADH1C	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
1196	Complement decay-accelerating factor	CD55	0.0029
1864	RET proto-oncogene	RET	0.0029
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0029
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0029
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0029
751	Potassium channel subfamily K member 6	KCNK6	0.0029
162	Retinoic acid receptor gamma-1	RARG	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
2207	Rhodopsin	RHO	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0027
6167	Organic solute transporter subunit beta	OSTB	0.0027
6166	Organic solute transporter subunit alpha	OSTA	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
172	Potassium channel subfamily K member 1	KCNK1	0.0027
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0026
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
4192	DNA topoisomerase 2-beta	TOP2B	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
1039	Histone deacetylase 9	HDAC9	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
2808	Chloramphenicol acetyltransferase 3	cat3	0.0026
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0025
6859	Protein S100-A4	S100A4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
3830	Calreticulin	CALR	0.0025
4217	Telomerase reverse transcriptase	TERT	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
896	Glutathione S-transferase Mu 1	GSTM1	0.0025
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0025
572	Integrin alpha-L	ITGAL	0.0025
2268	Cholesterol oxidase	choB	0.0025
2822	Cholesterol oxidase	choA	0.0025
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0025
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
267	Plasminogen activator inhibitor 1	SERPINE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
3639	Thymidine phosphorylase	deoA	0.0024
3936	Thymidine phosphorylase	TYMP	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3808	Dihydropteroate synthase 2	folP2	0.0023
3601	Dihydropteroate synthase 1	folP1	0.0023
3807	Dihydropteroate synthase 1	folP1	0.0023
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
3086	Plasmepsin-2	Not Available	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
2417	Chloramphenicol acetyltransferase	cat	0.0023
3278	Chloramphenicol acetyltransferase	cat	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
5923	Microtubule-associated protein tau	MAPT	0.0023
5924	Microtubule-associated protein 4	MAP4	0.0023
2810	Dr hemagglutinin structural subunit	draA	0.0023
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0023
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0023
76	Nitric-oxide synthase, brain	NOS1	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
6221	Steroid hormone receptor ERR1	ESRRA	0.0022
3404	Exotoxin A	eta	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
6163	Copper-transporting ATPase 2	ATP7B	0.0021
6165	Copper-transporting ATPase 1	ATP7A	0.0021
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0021
1268	Neuropeptide S receptor	NPSR1	0.0021
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0021
268	Adenosine A2b receptor	ADORA2B	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
6048	Troponin C, skeletal muscle	TNNC2	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
719	Retinoic acid receptor responder protein 1	RARRES1	0.002
770	Retinoic acid-induced protein 3	GPRC5A	0.002
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.002
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.002
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.002
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.002
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0019
2320	Thymidine kinase, cytosolic	TK1	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0019
6072	Potassium channel subfamily K member 3	KCNK3	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
3102	Flavohemoprotein	hmp	0.0019
4969	Flavohemoprotein	hmp	0.0019
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0019
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
3426	Glutamine synthetase	glnA	0.0019
3987	Glutamine synthetase	GLUL	0.0019
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
5626	Nucleoside diphosphate kinase B	NME2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
569	Retinal dehydrogenase 2	ALDH1A2	0.0018
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0018
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
4486	Phenol 2-hydroxylase component B	pheA2	0.0018
2021	Thrombomodulin	THBD	0.0018
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0018
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0018
5117	Dihydrolipoyl dehydrogenase	lpd	0.0018
4439	Ferredoxin reductase	bphA4	0.0018
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0018
526	Thioredoxin reductase	trxB	0.0018
3767	Thioredoxin reductase	trxB	0.0018
5122	Mersacidin decarboxylase	mrsD	0.0017
5095	Putidaredoxin reductase	camA	0.0017
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0017
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0017
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0017
5109	Outer membrane protein p64k or PM-6	m-6	0.0017
5115	FkbI	fkbI	0.0017
3133	UDP-galactopyranose mutase	glf	0.0017
5099	UDP-galactopyranose mutase	glf	0.0017
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0017
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0017
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0017
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0017
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0017
5111	Phenylacetone monooxygenase	pamO	0.0017
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0017
5083	Cryptochrome DASH	cry	0.0017
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0017
5081	L-aspartate oxidase	nadB	0.0017
1410	Oxidoreductase	HSD17B6	0.0017
4725	Oxidoreductase	Not Available	0.0017
5124	Oxidoreductase	Not Available	0.0017
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
6677	Myelin P2 protein	PMP2	0.0017
6218	Pannexin-1	PANX1	0.0017
484	Tyrosine-protein kinase ABL2	ABL2	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
760	Fibroblast growth factor 1	FGF1	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
611	Retinal dehydrogenase 1	ALDH1A1	0.0017
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0017
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0017
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0017
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0017
6168	Solute carrier family 22 member 16	SLC22A16	0.0017
2216	Fibroblast growth factor receptor 4	FGFR4	0.0016
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0016
1243	Cathepsin D	CTSD	0.0016
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
4440	NADH peroxidase	npr	0.0015
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0015
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0015
3594	Deoxyribodipyrimidine photo-lyase	phr	0.0015
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.0015
5080	Deoxyribodipyrimidine photo-lyase	phr	0.0015
6755	Poliovirus receptor	PVR	0.0015
5072	N,N-dimethylglycine oxidase	dmg	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
2470	Pyruvate oxidase	pox5	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
5073	Ferredoxin--NADP reductase	petH	0.0015
5076	Ferredoxin--NADP reductase	fpr	0.0015
5119	Ferredoxin--NADP reductase	petH	0.0015
5121	Ferredoxin--NADP reductase	fpr	0.0015
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0015
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0015
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0015
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0015
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.0015
2526	NADPH-ferredoxin reductase fprA	fprA	0.0015
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.0015
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.0015
489	Monocarboxylate transporter 2	SLC16A7	0.0015
6689	TraN protein	traN	0.0015
6672	Destrin	DSTN	0.0015
6680	Cofilin-1	CFL1	0.0015
6670	Ig kappa chain V-I region Bi	Not Available	0.0015
6671	Ig heavy chain V-III region VH26	Not Available	0.0015
6688	TraF protein	traF	0.0015
6404	Rhomboid protease glpG	glpG	0.0015
6797	Rhomboid protease glpG	glpG	0.0015
3710	Acyl-CoA thioesterase 2	tesB	0.0015
6685	Outer membrane protein II	porB	0.0015
6690	BenF-like porin	PFL_1329	0.0015
6681	Probable N-acetylneuraminic acid outer membrane channel protein nanC	nanC	0.0015
6687	TraO protein	traO	0.0015
6668	Cytochrome c oxidase subunit 1-beta	ctaDII	0.0015
6679	Colicin-Ia	cia	0.0015
6676	Fe(3+)-pyochelin receptor	fptA	0.0015
115	Penicillin-binding protein 2	mrdA	0.0015
6069	Penicillin-binding protein 2	mrdA	0.0015
6118	Penicillin-binding protein 2	penA	0.0015
6187	Penicillin-binding protein 2	pbpA	0.0015
6686	Penicillin-binding protein 2	pbp2	0.0015
6939	Penicillin-binding protein 2	mrdA	0.0015
7163	Penicillin-binding protein 2	pbpA	0.0015
6674	Nuclear factor erythroid 2-related factor 1	NFE2L1	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
1525	Heparin-binding growth factor 2	FGF2	0.0015
5294	Nucleoside diphosphate kinase A	NME1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0015
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0015
4210	Toll-like receptor 4	TLR4	0.0014
126	D-lactate dehydrogenase	dld	0.0014
3545	D-lactate dehydrogenase	Not Available	0.0014
4510	D-lactate dehydrogenase	ldhA	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
4226	Uridine phosphorylase 2	UPP2	0.0014
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.0014
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0014
2893	Glycine oxidase	thiO	0.0014
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0013
2567	Thymidylate synthase thyX	thyX	0.0013
6228	Nuclear receptor coactivator 1	NCOA1	0.0013
2823	Trypanothione reductase	TPR	0.0013
2769	P-hydroxybenzoate hydroxylase	pobA	0.0013
2809	P-hydroxybenzoate hydroxylase	pobA	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
4760	Mll3241 protein	mll3241	0.0013
3395	Iron(III) dicitrate transport protein fecA	fecA	0.0013
6385	H subunit of photosynthetic reaction center complex	puhA	0.0013
6474	Outer membrane protein W	ompW	0.0013
6678	Colicin I receptor	cirA	0.0013
3578	Protein crcA	crcA	0.0013
6675	Colicin-E3	ceaC	0.0013
2925	Long-chain fatty acid transport protein	fadL	0.0013
6480	Outer membrane usher protein papC	papC	0.0013
6438	Outer membrane protein G	ompG	0.0013
2447	Ammonia channel	amtB	0.0013
4225	Uridine phosphorylase 1	UPP1	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
6042	Prostaglandin reductase 2	PTGR2	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3221	Cytochrome c4	cc4	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
2380	Monomeric sarcosine oxidase	soxA	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
413	Amidophosphoribosyltransferase	PPAT	0.0012
2515	Amidophosphoribosyltransferase	purF	0.0012
3714	Amidophosphoribosyltransferase	purF	0.0012
1792	Tissue-type plasminogen activator	PLAT	0.0012
6645	D-amino-acid oxidase	DAO	0.0012
6428	Light-harvesting protein B-800/850 beta chain	Not Available	0.0012
6427	Light-harvesting protein B-800/850 alpha chain	Not Available	0.0012
6533	Light-harvesting protein B-800/850 alpha chain	A1	0.0012
1295	Fatty acid synthase	FASN	0.0012
6524	Protein tonB	tonB	0.0012
2679	Vitamin B12 transporter btuB	btuB	0.0012
6151	Monocarboxylate transporter 10	SLC16A10	0.0012
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6459	Glycodelin	PAEP	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
1313	Lactoylglutathione lyase	GLO1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
6352	Reaction center protein H chain	puhA	0.001
6456	Reaction center protein H chain	puhA	0.001
6682	Reaction center protein H chain	puhA	0.001
6353	Reaction center protein L chain	pufL	0.001
6454	Reaction center protein L chain	pufL	0.001
6683	Reaction center protein L chain	pufL	0.001
6354	Reaction center protein M chain	pufM	0.001
6455	Reaction center protein M chain	pufM	0.001
6684	Reaction center protein M chain	pufM	0.001
6351	Photosynthetic reaction center cytochrome c subunit	pufC	0.001
2828	Squalene--hopene cyclase	shc	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
2298	Cytochrome P450-cam	camC	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
1867	Major prion protein	PRNP	0.0008
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0008
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
822	Aldose reductase	AKR1B1	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1507	Cytochrome c	CYCS	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4916	Cyanoglobin	glbN	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
4984	Neuroglobin	NGB	0.0006
4943	Cytochrome c6	petJ	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4910	Cytoglobin	CYGB	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
5000	HemO	hemO	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4909	CooA protein	cooA	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
644	Heme oxygenase 2	HMOX2	0.0006
4982	Heme oxygenase 2	pbsA2	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4961	Hemophore HasA	hasA	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4972	P450cin	cinA	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
3093	Catalase HPII	katE	0.0006
4952	Catalase/peroxidase	katA	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
798	Osteocalcin	BGLAP	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
4920	Peroxidase/catalase	katG	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
1650	Heme carrier protein 1	SLC46A1	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
358	Cystathionine beta-synthase	CBS	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
810	Heme oxygenase 1	HMOX1	0.0003
3391	Heme oxygenase 1	pbsA1	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01104 - Sertraline

Targets

Enzymes

Transporters

Predictions