DT-Web

DB00508 - Triflupromazine


Identification
Name Triflupromazine
Accession Number DB00508 (APRD00465)
Type small molecule
Description A phenothiazine used as an antipsychotic agent and as an antiemetic. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 352.417
Groups approved
Monoisotopic Weight 352.122103923
Pharmacology
Indication Used mainly in the management of psychoses. Also used to control nausea and vomiting.
Mechanism of action Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Triflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT2B).
Absorption Absorption may be erratic and peak plasma concentrations show large interindividual differences.
Protein binding Very high (90% or more).
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Bromocriptine The phenothiazine decreases the effect of bromocriptine
Cisapride Increased risk of cardiotoxicity and arrhythmias
Dexfenfluramine Decreased anorexic effect, may increase psychotic symptoms
Diethylpropion Decreased anorexic effect, may increase psychotic symptoms
Donepezil Possible antagonism of action
Fenfluramine Decreased anorexic effect, may increase psychotic symptoms
Galantamine Possible antagonism of action
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Guanethidine Triflupromazine may decrease the effect of guanethidine.
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Mazindol Decreased anorexic effect, may increase psychotic symptoms
Phentermine Decreased anorexic effect, may increase psychotic symptoms
Phenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Food Interactions Not Available

Targets


D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.3282
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.404
5-hydroxytryptamine 2B receptor
Name 5-hydroxytryptamine 2B receptor
Gene Name HTR2B
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Cooper M, Wyllie JH: Some properties of 5-hydroxytryptamine receptors in the hindquarters of the rat. Br J Pharmacol. 1979 Sep;67(1):79-85. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.2004
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Snyder S, Greenberg D, Yamamura HI: Antischizophrenic drugs and brain cholinergic receptors. Affinity for muscarinic sites predicts extrapyramidal effects. Arch Gen Psychiatry. 1974 Jul;31(1):58-61. - Pubmed
DTHybrid score 0.6022
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Snyder S, Greenberg D, Yamamura HI: Antischizophrenic drugs and brain cholinergic receptors. Affinity for muscarinic sites predicts extrapyramidal effects. Arch Gen Psychiatry. 1974 Jul;31(1):58-61. - Pubmed
DTHybrid score 0.4668

Enzymes


Cholinesterase
Name Cholinesterase
Gene Name BCHE
Actions inhibitor
References
  • Muraoka S, Miura T: Inactivation of cholinesterase induced by chlorpromazine cation radicals. Pharmacol Toxicol. 2003 Feb;92(2):100-4. - Pubmed
DTHybrid score 0.6375

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Ibrahim S, Peggins J, Knapton A, Licht T, Aszalos A: Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation. J Pharmacol Exp Ther. 2000 Dec;295(3):1276-83. - Pubmed
DTHybrid score 0.3066

Predictions


Id Partner name Gene Name Score
51 Muscarinic acetylcholine receptor M3 CHRM3 0.3022
502 5-hydroxytryptamine 2A receptor HTR2A 0.236
4119 Cytochrome P450 2D6 CYP2D6 0.2114
4512 Cytochrome P450 3A4 CYP3A4 0.2037
450 Muscarinic acetylcholine receptor M4 CHRM4 0.1854
590 5-hydroxytryptamine 2C receptor HTR2C 0.1675
274 Muscarinic acetylcholine receptor M5 CHRM5 0.1569
556 Alpha-1A adrenergic receptor ADRA1A 0.1346
638 D(3) dopamine receptor DRD3 0.1289
320 5-hydroxytryptamine 1A receptor HTR1A 0.1274
432 D(4) dopamine receptor DRD4 0.1189
318 Alpha-2A adrenergic receptor ADRA2A 0.1182
474 Acetylcholinesterase ACHE 0.1145
4200 Cytochrome P450 1A2 CYP1A2 0.1128
492 Histamine H1 receptor HRH1 0.1108
163 D(1B) dopamine receptor DRD5 0.1079
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0973
629 Alpha-2B adrenergic receptor ADRA2B 0.0897
378 Alpha-2C adrenergic receptor ADRA2C 0.0865
632 Alpha-1B adrenergic receptor ADRA1B 0.0839
725 5-hydroxytryptamine 1D receptor HTR1D 0.0834
885 5-hydroxytryptamine 1B receptor HTR1B 0.0809
6016 Cytochrome P450 2C19 CYP2C19 0.0768
824 Sodium-dependent serotonin transporter SLC6A4 0.0748
4757 Cytochrome P450 2C9 CYP2C9 0.0692
716 5-hydroxytryptamine 7 receptor HTR7 0.0649
4118 Cytochrome P450 3A5 CYP3A5 0.0634
6145 Solute carrier family 22 member 1 SLC22A1 0.059
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0538
4924 Cytochrome P450 2C8 CYP2C8 0.0535
6013 Cytochrome P450 2E1 CYP2E1 0.0492
789 Alpha-1D adrenergic receptor ADRA1D 0.0474
587 Serum albumin ALB 0.046
6030 Cytochrome P450 2B6 CYP2B6 0.0448
6107 Cytochrome P450 3A7 CYP3A7 0.0441
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0412
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0385
6144 Solute carrier family 22 member 2 SLC22A2 0.0354
766 Beta-2 adrenergic receptor ADRB2 0.0354
124 Histamine H2 receptor HRH2 0.0328
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0327
465 Calmodulin CALM1 0.0315
713 Sodium-dependent dopamine transporter SLC6A3 0.0311
6024 Cytochrome P450 1A1 CYP1A1 0.0306
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0302
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.03
1256 5-hydroxytryptamine 6 receptor HTR6 0.0291
341 5-hydroxytryptamine 3 receptor HTR3A 0.0268
528 5-hydroxytryptamine 1E receptor HTR1E 0.0246
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0226
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0222
5718 Cytochrome P450 2A6 CYP2A6 0.0217
131 Synaptic vesicular amine transporter SLC18A2 0.0216
3941 Amine oxidase [flavin-containing] A MAOA 0.0215
2433 Capsid protein P40 UL80 0.0213
3569 Capsid protein P40 BVRF2 0.0213
118 Organic cation/carnitine transporter 2 SLC22A5 0.0212
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0205
833 Organic cation/carnitine transporter 1 SLC22A4 0.0201
2049 Gastrin/cholecystokinin type B receptor CCKBR 0.0191
193 Beta-1 adrenergic receptor ADRB1 0.0187
3076 Antigen 85-C fbpC 0.0187
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0187
20 Prostaglandin G/H synthase 1 PTGS1 0.0182
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0174
862 Multidrug resistance-associated protein 1 ABCC1 0.0167
244 Angiotensin-converting enzyme ACE 0.0164
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0161
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0159
1656 CYP2B protein CYP2B 0.0153
94 5-hydroxytryptamine 4 receptor HTR4 0.0153
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0149
290 Prostaglandin G/H synthase 2 PTGS2 0.0148
2796 Parathion hydrolase opd 0.0147
6539 Parathion hydrolase opd 0.0147
6106 Cytochrome P450 2C18 CYP2C18 0.0145
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0145
3454 Esterase estA 0.0141
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0137
871 Glucocorticoid receptor NR3C1 0.0135
723 Cytosolic phospholipase A2 PLA2G4A 0.0134
6147 Solute carrier family 22 member 3 SLC22A3 0.0133
776 Bile salt export pump ABCB11 0.013
2929 (S)-2-haloacid dehalogenase dhlB 0.0124
2995 (S)-2-haloacid dehalogenase Not Available 0.0124
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0118
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0116
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0115
3811 Cytochrome P450 19A1 CYP19A1 0.0114
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0111
5251 Carbonyl reductase [NADPH] 1 CBR1 0.011
6432 Transporter snf 0.011
2129 Sucrase-isomaltase, intestinal SI 0.0108
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0106
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0105
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0105
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0102
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0097
380 Cytochrome P450 17A1 CYP17A1 0.0097
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0091
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0089
3426 Glutamine synthetase glnA 0.0089
3987 Glutamine synthetase GLUL 0.0089
1898 Cytochrome P450 1B1 CYP1B1 0.0088
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0088
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0087
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0086
614 Progesterone receptor PGR 0.0084
3947 Xanthine dehydrogenase/oxidase XDH 0.0083
275 Arachidonate 5-lipoxygenase ALOX5 0.0082
1729 Solute carrier family 22 member 6 SLC22A6 0.008
3939 Amine oxidase [flavin-containing] B MAOB 0.0079
737 Mineralocorticoid receptor NR3C2 0.0075
923 Glutamate receptor 3 GRIA3 0.0074
904 Glutathione S-transferase P GSTP1 0.0073
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0073
511 5-hydroxytryptamine 1F receptor HTR1F 0.0073
136 Estrogen receptor ESR1 0.0072
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
4604 Liver carboxylesterase 1 CES1 0.0069
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0069
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0067
1353 DNA topoisomerase 1 TOP1 0.0066
3552 DNA topoisomerase 1 topA 0.0066
817 DNA topoisomerase 2-alpha TOP2A 0.0065
85 Growth hormone receptor GHR 0.0065
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0064
146 Androgen receptor AR 0.0064
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
468 Cytochrome P450 4A11 CYP4A11 0.0062
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.006
6142 Solute carrier family 22 member 8 SLC22A8 0.006
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0059
6143 Solute carrier family 22 member 7 SLC22A7 0.0059
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0057
467 Delta-type opioid receptor OPRD1 0.0055
6137 Multidrug resistance-associated protein 6 ABCC6 0.0055
1192 Sulfotransferase 1A1 SULT1A1 0.0055
174 Sigma 1-type opioid receptor SIGMAR1 0.0053
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0053
232 Corticosteroid-binding globulin SERPINA6 0.0053
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0053
6859 Protein S100-A4 S100A4 0.0053
6182 Cytochrome P450 2J2 CYP2J2 0.0052
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0052
694 Matrix protein 2 M 0.0051
696 Kappa-type opioid receptor OPRK1 0.0051
844 Epidermal growth factor receptor EGFR 0.005
731 HIV-1 protease HIV-1 protease 0.005
1517 Beta-3 adrenergic receptor ADRB3 0.0048
847 Mu-type opioid receptor OPRM1 0.0048
921 Glutamate receptor 2 GRIA2 0.0047
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
144 Hemoglobin subunit alpha HBA1 0.0046
4784 Beta-mannosidase manB 0.0046
6695 Beta-mannosidase BT_0458 0.0046
1178 Adenosine A2a receptor ADORA2A 0.0046
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0046
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0045
6151 Monocarboxylate transporter 10 SLC16A10 0.0045
2164 Multidrug resistance-associated protein 4 ABCC4 0.0045
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0045
427 Substance-P receptor TACR1 0.0045
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0045
4120 NADPH--cytochrome P450 reductase POR 0.0043
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0043
6141 Sodium/bile acid cotransporter SLC10A1 0.0043
260 Cytochrome P450 51 ERG11 0.0043
761 Cytochrome P450 51 ERG11 0.0043
3163 Cytochrome P450 51 cyp51 0.0043
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0043
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0042
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0042
869 Estrogen receptor beta ESR2 0.0042
6148 Multidrug resistance-associated protein 7 ABCC10 0.0042
3480 Mannan endo-1,4-beta-mannosidase manA 0.0041
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.004
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.004
952 Dipeptidyl peptidase 4 DPP4 0.004
161 Tubulin beta chain TUBB 0.0039
312 Tubulin beta chain TUB2 0.0039
164 Histamine H4 receptor HRH4 0.0039
6136 Multidrug resistance-associated protein 5 ABCC5 0.0039
504 Mast/stem cell growth factor receptor KIT 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0036
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0036
4787 Envelope glycoprotein gp160 env 0.0036
4820 Envelope glycoprotein gp160 env 0.0036
5727 Envelope glycoprotein gp160 env 0.0036
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
3810 Catechol O-methyltransferase COMT 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
2297 Genome polyprotein Not Available 0.0034
2322 Genome polyprotein Not Available 0.0034
2694 Genome polyprotein Not Available 0.0034
2719 Genome polyprotein Not Available 0.0034
2860 Genome polyprotein Not Available 0.0034
2928 Genome polyprotein Not Available 0.0034
3160 Genome polyprotein Not Available 0.0034
3260 Genome polyprotein Not Available 0.0034
4783 Genome polyprotein Not Available 0.0034
5726 Genome polyprotein Not Available 0.0034
5779 Genome polyprotein Not Available 0.0034
5867 Genome polyprotein Not Available 0.0034
6253 Genome polyprotein Not Available 0.0034
6301 Genome polyprotein Not Available 0.0034
6380 Genome polyprotein Not Available 0.0034
6381 Genome polyprotein Not Available 0.0034
6437 Genome polyprotein Not Available 0.0034
6520 Genome polyprotein Not Available 0.0034
6521 Genome polyprotein Not Available 0.0034
6652 Genome polyprotein Not Available 0.0034
6734 Genome polyprotein Not Available 0.0034
6735 Genome polyprotein Not Available 0.0034
6736 Genome polyprotein Not Available 0.0034
6737 Genome polyprotein Not Available 0.0034
6738 Genome polyprotein Not Available 0.0034
6739 Genome polyprotein Not Available 0.0034
6744 Genome polyprotein Not Available 0.0034
6748 Genome polyprotein Not Available 0.0034
6894 Genome polyprotein Not Available 0.0034
6898 Genome polyprotein Not Available 0.0034
153 Dopamine beta-hydroxylase DBH 0.0034
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0032
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
2499 Tubulin beta-2C chain TUBB2C 0.0031
1360 Sphingomyelin phosphodiesterase SMPD1 0.0031
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0031
1024 Solute carrier family 22 member 11 SLC22A11 0.0031
3437 Eosinophil lysophospholipase CLC 0.003
756 Sex hormone-binding globulin SHBG 0.003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.003
1618 High affinity nerve growth factor receptor NTRK1 0.0029
26 Vascular endothelial growth factor receptor 3 FLT4 0.0029
2207 Rhodopsin RHO 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
683 Potassium transporter GK0582 0.0029
70 Type-1 angiotensin II receptor AGTR1 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
32 Vascular endothelial growth factor receptor 1 FLT1 0.0028
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
777 Tumor necrosis factor TNF 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
407 Vascular endothelial growth factor receptor 2 KDR 0.0026
228 Beta platelet-derived growth factor receptor PDGFRB 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
6131 Carbonic anhydrase 14 CA14 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0026
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0026
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0023
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0023
373 Transthyretin TTR 0.0023
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0023
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0023
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0023
738 Monocarboxylate transporter 1 SLC16A1 0.0023
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0022
4785 Ig gamma-1 chain C region IGHG1 0.0022
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0022
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0021
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0021
24 Thymidylate synthase TMP1 0.0021
359 Thymidylate synthase TYMS 0.0021
2626 Thymidylate synthase thyA 0.0021
2729 Thymidylate synthase thyA 0.0021
5352 Thymidylate synthase THYA 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.002
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0019
908 Glutathione S-transferase theta-1 GSTT1 0.0019
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0019
6085 Fatty acid-binding protein, intestinal FABP2 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0018
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0018
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0018
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0018
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0018
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0018
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0018
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0017
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0017
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0017
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0017
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0017
3927 Choline transporter-like protein 3 SLC44A3 0.0017
861 Choline kinase alpha CHKA 0.0017
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0017
769 High-affinity choline transporter 1 SLC5A7 0.0017
700 Choline dehydrogenase, mitochondrial CHDH 0.0017
1686 Choline transporter-like protein 1 SLC44A1 0.0017
3926 Choline transporter-like protein 2 SLC44A2 0.0017
3925 Choline transporter-like protein 4 SLC44A4 0.0017
576 Choline O-acetyltransferase CHAT 0.0017
3922 Phospholipase D2 PLD2 0.0017
3924 Phospholipase D1 PLD1 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0017
6163 Copper-transporting ATPase 2 ATP7B 0.0017
6165 Copper-transporting ATPase 1 ATP7A 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
6824 Tyrosine-protein kinase Lyn LYN 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
6146 High affinity copper uptake protein 1 SLC31A1 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0016
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0016
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0016
6755 Poliovirus receptor PVR 0.0015
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0015
702 UMP-CMP kinase CMPK1 0.0015
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0015
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
6031 Cytochrome P450 3A43 CYP3A43 0.0015
165 FL cytokine receptor FLT3 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
6149 Solute carrier family 22 member 10 SLC22A10 0.0015
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0014
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
1629 Transcription factor AP-1 JUN 0.0014
896 Glutathione S-transferase Mu 1 GSTM1 0.0014
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0014
273 Apoptosis regulator Bcl-2 BCL2 0.0013
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0013
6167 Organic solute transporter subunit beta OSTB 0.0013
6166 Organic solute transporter subunit alpha OSTA 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0013
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0013
365 Dihydrofolate reductase DHFR 0.0013
2381 Dihydrofolate reductase DFR1 0.0013
2833 Dihydrofolate reductase Not Available 0.0013
2931 Dihydrofolate reductase folA 0.0013
3544 Dihydrofolate reductase folA 0.0013
3682 Dihydrofolate reductase folA 0.0013
6642 Dihydrofolate reductase folA 0.0013
6756 Dihydrofolate reductase dfrA 0.0013
4773 Deoxycytidine kinase DCK 0.0012
4498 Ornithine cyclodeaminase PP3533 0.0012
1757 Myeloperoxidase MPO 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0012
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0012
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0012
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0012
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0012
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0012
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0012
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0012
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0012
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0012
5449 Hypothetical gliding protein mglB 0.0012
5443 UPF0189 protein ymdB ymdB 0.0012
5440 UPF0067 protein yebR yebR 0.0012
4705 Manganese catalase Not Available 0.0012
5439 33 kDa chaperonin hslO 0.0012
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0012
2720 Copper-containing nitrite reductase nirK 0.0012
5448 Ribonuclease Z rnz 0.0012
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0012
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0012
5454 Internalin-A inlA 0.0012
332 Beta-lactamase blaZ 0.0012
2478 Beta-lactamase ampC 0.0012
2613 Beta-lactamase ampC 0.0012
2635 Beta-lactamase ampC 0.0012
2700 Beta-lactamase penP 0.0012
5445 Beta-lactamase blaB 0.0012
6019 Beta-lactamase SHV-7 0.0012
6701 Beta-lactamase cphA 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0011
469 Annexin A1 ANXA1 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0011
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0011
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0011
5450 Prolyl endopeptidase Pep pep 0.0011
3356 Diaminopimelate decarboxylase lysA 0.001
597 Dihydropteridine reductase QDPR 0.001
4771 Dissimilatory copper-containing nitrite reductase nir 0.001
3274 Hydroxylamine reductase hcp 0.001
4804 Hydroxylamine reductase hcp 0.001
2714 Chorismate mutase aroH 0.001
4611 Chorismate mutase aroG 0.001
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
4203 Histamine N-methyltransferase HNMT 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.001
811 Translocator protein TSPO 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
68 Cannabinoid receptor 1 CNR1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
3399 Limonene-1,2-epoxide hydrolase limA 0.001
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.001
4192 DNA topoisomerase 2-beta TOP2B 0.001
3957 Adenosine deaminase ADA 0.0009
936 Ephrin type-A receptor 2 EPHA2 0.0009
4608 Putative cytochrome P450 SCO1207 0.0009
4963 Putative cytochrome P450 SCO2884 0.0009
6254 Putative cytochrome P450 SCO6998 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
5180 L(+)-mandelate dehydrogenase mdlB 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
577 Argininosuccinate lyase ASL 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
3500 Putative family 31 glucosidase yicI yicI 0.0009
4878 Glycoprotein hormones alpha chain CGA 0.0009
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1072 Granzyme B GZMB 0.0009
4889 Ig epsilon chain C region IGHE 0.0009
4877 Beta-mannanase man 0.0009
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0009
4189 Alpha-galactosidase A GLA 0.0009
4850 Beta-2-glycoprotein 1 APOH 0.0009
4880 Membrane cofactor protein CD46 0.0009
4856 CD209 antigen CD209 0.0009
1354 Beta-glucuronidase GUSB 0.0009
757 Fusion glycoprotein F0 F 0.0009
4875 Fusion glycoprotein F0 F 0.0009
4869 Major capsid protein A430L 0.0009
4852 Reticulon-4 receptor RTN4R 0.0009
4845 ADAM 33 ADAM33 0.0009
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0009
442 Envelope glycoprotein gp41 0.0009
4859 Envelope glycoprotein env 0.0009
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0009
4721 Beta-1,4-mannanase manA 0.0009
3352 Structural polyprotein Not Available 0.0009
3628 Structural polyprotein Not Available 0.0009
4892 Structural polyprotein Not Available 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0009
1615 Chymase CMA1 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
54 Prothrombin F2 0.0009
3932 Glutathione S-transferase A2 GSTA2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
5787 Angiopoietin-1 receptor TEK 0.0008
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0008
823 Fibroblast growth factor receptor 2 FGFR2 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0008
4861 Interleukin-6 receptor alpha chain IL6R 0.0008
793 T-cell surface antigen CD2 CD2 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0008
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0008
3837 Cytokine receptor common beta chain CSF2RB 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
7 Nitric oxide synthase, inducible NOS2 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
4890 Hemagglutinin HA 0.0007
6566 Hemagglutinin Not Available 0.0007
1379 Interleukin-12 subunit beta IL12B 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0007
6858 Inactive carboxylesterase 4 CES1P1 0.0007
1184 Interferon beta IFNB1 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
1630 Integrin beta-2 ITGB2 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0007
976 Platelet glycoprotein IX GP9 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
6500 Phospholipase A2 PLA2G1B 0.0006
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0006
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
554 Low-density lipoprotein receptor LDLR 0.0006
852 Heparin cofactor 2 SERPIND1 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0006
1859 Prostatic acid phosphatase ACPP 0.0006
3444 Cyanovirin-N Not Available 0.0006
3140 Hemagglutinin-neuraminidase HN 0.0006
3609 Hemagglutinin-neuraminidase HN 0.0006
595 Fibrinogen alpha chain FGA 0.0006
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
2981 Phospholipase A2, membrane associated PLA2G2A 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0005
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
4666 Fucose-binding lectin PA-IIL lecB 0.0005
2372 Bifunctional tail protein 9 0.0005
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
958 Insulin-like growth factor 1 receptor IGF1R 0.0005
2021 Thrombomodulin THBD 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
572 Integrin alpha-L ITGAL 0.0005
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
3814 Complement C1r subcomponent C1R 0.0005
16 Adenosine A1 receptor ADORA1 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
64 Neuraminidase NA 0.0005
641 Neuraminidase NA 0.0005
2676 Neuraminidase NA 0.0005
3026 Neuraminidase NA 0.0005
3519 Neuraminidase NA 0.0005
6007 Neuraminidase NA 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
1243 Cathepsin D CTSD 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
1439 Lactotransferrin LTF 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0005
309 Antithrombin-III SERPINC1 0.0005
4122 Histone deacetylase 2 HDAC2 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
291 Nitric-oxide synthase, endothelial NOS3 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
2430 Chondroitinase B cslB 0.0004
6102 Arylamine N-acetyltransferase 2 NAT2 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
6307 Ig gamma-2 chain C region IGHG2 0.0004
6218 Pannexin-1 PANX1 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
751 Potassium channel subfamily K member 6 KCNK6 0.0004
2581 Chondroitinase AC cslA 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
6847 Lactase-phlorizin hydrolase LCT 0.0004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
6220 Aryl hydrocarbon receptor AHR 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
6043 Putative G-protein coupled receptor 44 GPR44 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0004
6014 Cytochrome P450 2A13 CYP2A13 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
284 DNA-directed RNA polymerase beta chain rpoB 0.0003
5773 DNA-directed RNA polymerase beta chain rpoB 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0003
295 Carbonic anhydrase 1 CA1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0002
6020 Aldehyde oxidase AOX1 0.0002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0002
517 Alcohol dehydrogenase 1C ADH1C 0.0002
↑