DT-Web

DB00625 - Efavirenz


Identification
Name Efavirenz
Accession Number DB00625 (APRD00059, DB07709)
Type small molecule
Description Efavirenz (brand names Sustiva(R) and Stocrin(R)) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 315.675
Groups approved
Monoisotopic Weight 315.027390859
Pharmacology
Indication For use in combination treatment of HIV infection (AIDS)
Mechanism of action Similar to zidovudine, efavirenz inhibits the activity of viral RNA-directed DNA polymerase (i.e., reverse transcriptase). Antiviral activity of efavirenz is dependent on intracellular conversion to the active triphosphorylated form. The rate of efavirenz phosphorylation varies, depending on cell type. It is believed that inhibition of reverse transcriptase interferes with the generation of DNA copies of viral RNA, which, in turn, are necessary for synthesis of new virions. Intracellular enzymes subsequently eliminate the HIV particle that previously had been uncoated, and left unprotected, during entry into the host cell. Thus, reverse transcriptase inhibitors are virustatic and do not eliminate HIV from the body. Even though human DNA polymerase is less susceptible to the pharmacologic effects of triphosphorylated efavirenz, this action may nevertheless account for some of the drug's toxicity.
Absorption Not Available
Protein binding 99.5-99.75%
Biotransformation Efavirenz is principally metabolized by the cytochrome P450 system to hydroxylated metabolites with subsequent glucuronidation of these hydroxylated metabolites. These metabolites are essentially inactive against HIV-1.
Route of elimination Nearly all of the urinary excretion of the radiolabeled drug was in the form of metabolites.
Toxicity Not Available
Affected organisms
  • Human Immunodeficiency Virus
Interactions
Drug Interactions
Drug Mechanism of interaction
Alprazolam The antiviral agent, efavirenz, may increase the effect and toxicity of the benzodiazepine, alprazolam.
Astemizole Increased risk of cardiotoxicity and arrhythmias
Atazanavir Efavirenz decreases the levels/effects of atazanavir
Atorvastatin Efavirenz may decrease the serum concentration of atorvastatin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of atorvastatin if efavirenz is initiated, discontinued or dose changed.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Clarithromycin Efavirenz decreases levels of clarithromycin
Cyclosporine Efavirenz decreases the levels of cyclosporine
Dihydroergotamine Efavirenze may increase the adverse/toxic effects of dihydroergotamine. Concomitant therapy is contraindicated.
Dihydroergotoxine The antiretroviral agent may increase the ergot derivative toxicity
Eltrombopag Affects hepatic enzyme CYP2C9/10 metabolism and may increase the level of eltrombopag.
Ergotamine The antiretroviral agent may increase the ergot derivative toxicity
Estradiol valerate/Dienogest Affects CYP3A4 metabolism, decreases or effects levels of Estradiol valerate/Dienogest.
Etravirine Etravirine, when used concomitantly with Efavirenz, may experience a significant decrease in plasma levels and a loss of efficacy. Combination of two NNRTIs has not been demonstrated to be of benefit to HIV therapy. It is recommended to avoid this combination.
Indinavir Efavirenz decreases the effect of indinavir
Lovastatin Efavirenz may decrease the serum concentration of lovastatin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of lovastatin if efavirenz is initiated, discontinued or dose changed.
Methadone Efavirenz may decrease the serum concentration of methadone by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of methadone if efavirenz is initiated, discontinued or dose changed.
Methylergonovine The antiretroviral agent may increase the ergot derivative toxicity
Methysergide The antiretroviral agent may increase the ergot derivative toxicity
Midazolam The antiviral agent, efavirenz, may increase the effect and toxicity of the benzodiazepine, midazolam.
Rilpivirine Concentration of rilpivirine decreases by affecting CYP3A4 metabolism. Concomitant use is contraindicated. Rilpivirine should not be used with other NNRTI's.
Roflumilast Affects CYP3A4 metabolism, decreases level or effect of roflumilast.
Saquinavir Efavirenz decreases the effect of saquinavir
Simvastatin Efavirenz may decrease the serum concentration of simvastatin. Monitor for changes in the therapeutic and adverse effects of simvastatin if efavirenz is initiated, discontinued or dose changed.
St. John's Wort St. John's Wort decreases the antiretroviral effect
Tamsulosin Efavirenz, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Efavirenz is initiated, discontinued, or dose changed.
Telaprevir Inducers of CYP3A enzymes will decrease telaprevir levels.
Telithromycin Efavirenz may decrease the plasma concentration of Telithromycin. Consider alternate therapy.
Temsirolimus Efavirenz may increase the metabolism of Temsirolimus decreasing its efficacy. Concomitant therapy should be avoided.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Tipranavir Efavirenz may alter the serum concentration Tipranavir. Monitor for changes in Tipranavir therapeutic and adverse effects if Efavirenz is initiated, discontinued or dose changed.
Tolterodine Efavirenz may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tramadol Efavirenz may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inhibitor and inducer, Efavirenz, may alter Trazodone efficacy/toxicity by altering Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Efavirenz is initiated, discontinued or dose changed.
Triazolam The antiviral agent, efavirenz, may increase the effect and toxicity of the benzodiazepine, triazolam.
Vandetanib Decreases levels of vandetanib by affecting CYP3A4 metabolism. Contraindicated.
Voriconazole Efavirenze may decrease the serum concentration of voriconazole likely by increasing its metabolism. Voriconazole may increase the serum concentration of efavirenz by decreasing its metabolism. Consider alternate therapy or adjust doses and monitor for reduced voriconazole efficacy and increased efavirenz adverse effects during concomitant therapy.
Food Interactions
  • Take without regard to meals.
  • Avoid excessive or chronic alcohol consumption.

Targets


Reverse transcriptase
Name Reverse transcriptase
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Xia Q, Radzio J, Anderson KS, Sluis-Cremer N: Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses. Protein Sci. 2007 Aug;16(8):1728-37. - Pubmed
  • Lindberg J, Sigurdsson S, Lowgren S, Andersson HO, Sahlberg C, Noreen R, Fridborg K, Zhang H, Unge T: Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant. Eur J Biochem. 2002 Mar;269(6):1670-7. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4089
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4562
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate,inhibitor,inducer
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Hesse LM, von Moltke LL, Shader RI, Greenblatt DJ: Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion. Drug Metab Dispos. 2001 Feb;29(2):100-2. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3125
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5922
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4205
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4702

Predictions


Id Partner name Gene Name Score
4924 Cytochrome P450 2C8 CYP2C8 0.2326
1588 Multidrug resistance protein 1 ABCB1 0.2091
4118 Cytochrome P450 3A5 CYP3A5 0.1865
6013 Cytochrome P450 2E1 CYP2E1 0.161
6107 Cytochrome P450 3A7 CYP3A7 0.1352
6024 Cytochrome P450 1A1 CYP1A1 0.1174
5718 Cytochrome P450 2A6 CYP2A6 0.1099
20 Prostaglandin G/H synthase 1 PTGS1 0.0875
587 Serum albumin ALB 0.0855
492 Histamine H1 receptor HRH1 0.0787
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0706
824 Sodium-dependent serotonin transporter SLC6A4 0.0677
6106 Cytochrome P450 2C18 CYP2C18 0.0618
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0572
502 5-hydroxytryptamine 2A receptor HTR2A 0.0523
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0519
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0506
831 D(2) dopamine receptor DRD2 0.0495
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0492
556 Alpha-1A adrenergic receptor ADRA1A 0.0487
3811 Cytochrome P450 19A1 CYP19A1 0.0453
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0452
290 Prostaglandin G/H synthase 2 PTGS2 0.0437
713 Sodium-dependent dopamine transporter SLC6A3 0.0417
6145 Solute carrier family 22 member 1 SLC22A1 0.0411
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0407
862 Multidrug resistance-associated protein 1 ABCC1 0.0399
1729 Solute carrier family 22 member 6 SLC22A6 0.0395
318 Alpha-2A adrenergic receptor ADRA2A 0.0395
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0387
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.037
766 Beta-2 adrenergic receptor ADRB2 0.0369
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0366
6144 Solute carrier family 22 member 2 SLC22A2 0.0357
590 5-hydroxytryptamine 2C receptor HTR2C 0.0352
1898 Cytochrome P450 1B1 CYP1B1 0.0351
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0335
731 HIV-1 protease HIV-1 protease 0.0334
51 Muscarinic acetylcholine receptor M3 CHRM3 0.033
23 D(1A) dopamine receptor DRD1 0.0326
3941 Amine oxidase [flavin-containing] A MAOA 0.032
320 5-hydroxytryptamine 1A receptor HTR1A 0.0318
193 Beta-1 adrenergic receptor ADRB1 0.0318
118 Organic cation/carnitine transporter 2 SLC22A5 0.0306
847 Mu-type opioid receptor OPRM1 0.0305
632 Alpha-1B adrenergic receptor ADRA1B 0.0305
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0302
136 Estrogen receptor ESR1 0.0301
341 5-hydroxytryptamine 3 receptor HTR3A 0.03
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0288
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0288
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0274
260 Cytochrome P450 51 ERG11 0.0273
761 Cytochrome P450 51 ERG11 0.0273
3163 Cytochrome P450 51 cyp51 0.0273
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0269
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0267
36 Insulin receptor INSR 0.0258
465 Calmodulin CALM1 0.025
467 Delta-type opioid receptor OPRD1 0.0249
776 Bile salt export pump ABCB11 0.0246
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0245
3939 Amine oxidase [flavin-containing] B MAOB 0.0244
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0243
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0242
696 Kappa-type opioid receptor OPRK1 0.0239
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0235
122 P2Y purinoceptor 12 P2RY12 0.0234
6142 Solute carrier family 22 member 8 SLC22A8 0.0232
885 5-hydroxytryptamine 1B receptor HTR1B 0.0229
468 Cytochrome P450 4A11 CYP4A11 0.0225
817 DNA topoisomerase 2-alpha TOP2A 0.0224
871 Glucocorticoid receptor NR3C1 0.0222
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0218
638 D(3) dopamine receptor DRD3 0.0216
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0216
2164 Multidrug resistance-associated protein 4 ABCC4 0.0213
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0205
789 Alpha-1D adrenergic receptor ADRA1D 0.0204
3923 Cholinesterase BCHE 0.0203
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0199
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0195
629 Alpha-2B adrenergic receptor ADRA2B 0.0194
6143 Solute carrier family 22 member 7 SLC22A7 0.0192
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.019
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.019
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0189
725 5-hydroxytryptamine 1D receptor HTR1D 0.0188
6147 Solute carrier family 22 member 3 SLC22A3 0.0186
833 Organic cation/carnitine transporter 1 SLC22A4 0.0185
891 Dihydropteroate synthase folP 0.0182
5359 Dihydropteroate synthase folP 0.0182
7175 Dihydropteroate synthase sulI 0.0182
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0177
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0177
6031 Cytochrome P450 3A43 CYP3A43 0.0174
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0169
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0168
146 Androgen receptor AR 0.0166
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0166
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0161
378 Alpha-2C adrenergic receptor ADRA2C 0.016
432 D(4) dopamine receptor DRD4 0.0158
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0156
6220 Aryl hydrocarbon receptor AHR 0.0155
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0149
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0149
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0147
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0146
477 DNA topoisomerase 4 subunit A parC 0.0146
886 DNA topoisomerase 4 subunit A parC 0.0146
6226 DNA topoisomerase 4 subunit A parC 0.0146
6182 Cytochrome P450 2J2 CYP2J2 0.0145
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.014
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0139
436 5-hydroxytryptamine 2B receptor HTR2B 0.0139
818 50S ribosomal protein L10 rplJ 0.0134
70 Type-1 angiotensin II receptor AGTR1 0.0133
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0132
124 Histamine H2 receptor HRH2 0.0132
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0129
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0128
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0126
1656 CYP2B protein CYP2B 0.0125
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0125
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0124
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0123
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
504 Mast/stem cell growth factor receptor KIT 0.0122
4120 NADPH--cytochrome P450 reductase POR 0.0121
777 Tumor necrosis factor TNF 0.0121
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0116
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0115
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0115
716 5-hydroxytryptamine 7 receptor HTR7 0.0115
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0114
474 Acetylcholinesterase ACHE 0.0113
6014 Cytochrome P450 2A13 CYP2A13 0.0113
482 Glycine receptor subunit alpha-1 GLRA1 0.0113
4604 Liver carboxylesterase 1 CES1 0.0112
163 D(1B) dopamine receptor DRD5 0.0112
1757 Myeloperoxidase MPO 0.0111
1024 Solute carrier family 22 member 11 SLC22A11 0.0111
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.011
94 5-hydroxytryptamine 4 receptor HTR4 0.011
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0109
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0109
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0109
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0109
6136 Multidrug resistance-associated protein 5 ABCC5 0.0108
6137 Multidrug resistance-associated protein 6 ABCC6 0.0108
174 Sigma 1-type opioid receptor SIGMAR1 0.0107
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0107
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0106
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0106
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0106
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0106
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0106
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0106
811 Translocator protein TSPO 0.0105
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0105
614 Progesterone receptor PGR 0.0104
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0104
407 Vascular endothelial growth factor receptor 2 KDR 0.0102
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0101
380 Cytochrome P450 17A1 CYP17A1 0.01
161 Tubulin beta chain TUBB 0.01
312 Tubulin beta chain TUB2 0.01
844 Epidermal growth factor receptor EGFR 0.01
1010 Cytochrome P450 51A1 CYP51A1 0.01
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.01
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0099
6148 Multidrug resistance-associated protein 7 ABCC10 0.0099
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0099
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0099
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
16 Adenosine A1 receptor ADORA1 0.0097
756 Sex hormone-binding globulin SHBG 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0096
49 Endothelin B receptor EDNRB 0.0096
427 Substance-P receptor TACR1 0.0095
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0095
26 Vascular endothelial growth factor receptor 3 FLT4 0.0094
869 Estrogen receptor beta ESR2 0.0093
232 Corticosteroid-binding globulin SERPINA6 0.0093
295 Carbonic anhydrase 1 CA1 0.0092
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0092
1178 Adenosine A2a receptor ADORA2A 0.0092
3947 Xanthine dehydrogenase/oxidase XDH 0.0091
578 Endothelin-1 receptor EDNRA 0.009
32 Vascular endothelial growth factor receptor 1 FLT1 0.009
6102 Arylamine N-acetyltransferase 2 NAT2 0.0088
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0086
228 Beta platelet-derived growth factor receptor PDGFRB 0.0085
921 Glutamate receptor 2 GRIA2 0.0085
705 Glutamate receptor 1 GRIA1 0.0082
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0082
365 Dihydrofolate reductase DHFR 0.0082
2381 Dihydrofolate reductase DFR1 0.0082
2833 Dihydrofolate reductase Not Available 0.0082
2931 Dihydrofolate reductase folA 0.0082
3544 Dihydrofolate reductase folA 0.0082
3682 Dihydrofolate reductase folA 0.0082
6642 Dihydrofolate reductase folA 0.0082
6756 Dihydrofolate reductase dfrA 0.0082
373 Transthyretin TTR 0.0081
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0081
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0081
131 Synaptic vesicular amine transporter SLC18A2 0.008
565 Extracellular calcium-sensing receptor CASR 0.008
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.008
173 Toll-like receptor 7 TLR7 0.0079
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0077
537 ATP synthase delta chain, mitochondrial ATP5D 0.0077
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0076
6020 Aldehyde oxidase AOX1 0.0076
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0076
1256 5-hydroxytryptamine 6 receptor HTR6 0.0074
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0073
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0073
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
4116 Dihydropteroate synthetase Not Available 0.0072
357 Carbonic anhydrase 2 CA2 0.0072
952 Dipeptidyl peptidase 4 DPP4 0.0072
4122 Histone deacetylase 2 HDAC2 0.0071
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
6141 Sodium/bile acid cotransporter SLC10A1 0.0068
563 Thyroid peroxidase TPO 0.0067
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0067
183 Vascular endothelial growth factor A VEGFA 0.0067
275 Arachidonate 5-lipoxygenase ALOX5 0.0067
29 Tubulin beta-1 chain TUBB1 0.0066
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0066
3810 Catechol O-methyltransferase COMT 0.0066
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0065
528 5-hydroxytryptamine 1E receptor HTR1E 0.0065
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0064
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0063
856 Vitamin D3 receptor VDR 0.0063
6432 Transporter snf 0.0063
133 Dihydropterate synthase sulI 0.0063
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0063
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0062
284 DNA-directed RNA polymerase beta chain rpoB 0.0062
5773 DNA-directed RNA polymerase beta chain rpoB 0.0062
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0062
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0061
511 5-hydroxytryptamine 1F receptor HTR1F 0.0061
1618 High affinity nerve growth factor receptor NTRK1 0.006
6126 Carbonic anhydrase 7 CA7 0.006
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0059
68 Cannabinoid receptor 1 CNR1 0.0058
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0058
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
6085 Fatty acid-binding protein, intestinal FABP2 0.0057
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0056
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0056
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0056
1517 Beta-3 adrenergic receptor ADRB3 0.0055
518 Peroxidase/catalase T katG 0.0055
6506 Stathmin-4 STMN4 0.0055
823 Fibroblast growth factor receptor 2 FGFR2 0.0055
581 Cytochrome P450 2R1 CYP2R1 0.0054
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0053
273 Apoptosis regulator Bcl-2 BCL2 0.0053
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0053
1629 Transcription factor AP-1 JUN 0.0053
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
814 Ryanodine receptor 1 RYR1 0.0052
738 Monocarboxylate transporter 1 SLC16A1 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0052
2112 Toll-like receptor 9 TLR9 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
780 Retinoic acid receptor RXR-gamma RXRG 0.0051
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.005
6043 Putative G-protein coupled receptor 44 GPR44 0.0049
6044 Serum paraoxonase/lactonase 3 PON3 0.0049
1275 Estrogen sulfotransferase SULT1E1 0.0048
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0048
6146 High affinity copper uptake protein 1 SLC31A1 0.0047
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
3932 Glutathione S-transferase A2 GSTA2 0.0047
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0047
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
88 Retinoic acid receptor RXR-beta RXRB 0.0046
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0046
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0046
634 Squalene monooxygenase SQLE 0.0046
7196 Squalene monooxygenase ERG1 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
904 Glutathione S-transferase P GSTP1 0.0045
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0045
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0045
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0044
1192 Sulfotransferase 1A1 SULT1A1 0.0044
6138 Multidrug resistance protein 3 ABCB4 0.0044
153 Dopamine beta-hydroxylase DBH 0.0044
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0044
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
737 Mineralocorticoid receptor NR3C2 0.0044
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0044
2539 Tubulin alpha-1 chain TUBA4A 0.0043
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0043
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0042
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0042
4311 tRNA TRDMT1 0.0042
4325 tRNA trmD 0.0042
4328 tRNA trmD 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0042
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0042
1992 Vitamin D-binding protein GC 0.0042
1648 Elastin ELN 0.0041
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
319 Opioid receptor, sigma 1 OPRS1 0.0041
1050 Bile salt sulfotransferase SULT2A1 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
84 Nuclear receptor 0B1 NR0B1 0.004
7 Nitric oxide synthase, inducible NOS2 0.004
54 Prothrombin F2 0.004
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.004
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.004
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.004
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0039
1541 Metalloproteinase mmp20 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
1630 Integrin beta-2 ITGB2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
165 FL cytokine receptor FLT3 0.0038
24 Thymidylate synthase TMP1 0.0038
359 Thymidylate synthase TYMS 0.0038
2626 Thymidylate synthase thyA 0.0038
2729 Thymidylate synthase thyA 0.0038
5352 Thymidylate synthase THYA 0.0038
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0038
85 Growth hormone receptor GHR 0.0038
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
208 DNA-directed RNA polymerase beta' chain rpoC 0.0037
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0037
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0036
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0036
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0036
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0036
239 Coagulation factor X F10 0.0036
251 Alcohol dehydrogenase 1A ADH1A 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
164 Histamine H4 receptor HRH4 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0035
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0034
2981 Phospholipase A2, membrane associated PLA2G2A 0.0034
820 Glycine receptor subunit alpha-2 GLRA2 0.0034
976 Platelet glycoprotein IX GP9 0.0034
33 Cystine/glutamate transporter SLC7A11 0.0033
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0033
558 Solute carrier family 12 member 1 SLC12A1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0033
4103 Proteasome subunit beta type 2 PSMB2 0.0033
4102 Proteasome subunit beta type 5 PSMB5 0.0033
4101 Proteasome subunit beta type 1 PSMB1 0.0033
1483 Membrane copper amine oxidase AOC3 0.0033
3957 Adenosine deaminase ADA 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
3937 Fatty-acid amide hydrolase FAAH 0.0032
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0032
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0032
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0032
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0032
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0032
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0032
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0032
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0032
444 Alcohol dehydrogenase 1B ADH1B 0.0032
5787 Angiopoietin-1 receptor TEK 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1262 Corticotropin-lipotropin POMC 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
5934 Cytochrome P450 26A1 CYP26A1 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
5300 Antigen peptide transporter 1 TAP1 0.0031
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
106 Cannabinoid receptor 2 CNR2 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6174 50S ribosomal protein L32 rpmF 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
1196 Complement decay-accelerating factor CD55 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
936 Ephrin type-A receptor 2 EPHA2 0.0028
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0028
3809 Estrogen-related receptor gamma ESRRG 0.0028
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0028
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0028
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
517 Alcohol dehydrogenase 1C ADH1C 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
3856 Fibroblast growth factor receptor 3 FGFR3 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
1039 Histone deacetylase 9 HDAC9 0.0026
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0026
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0026
2808 Chloramphenicol acetyltransferase 3 cat3 0.0026
291 Nitric-oxide synthase, endothelial NOS3 0.0025
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
469 Annexin A1 ANXA1 0.0025
6149 Solute carrier family 22 member 10 SLC22A10 0.0025
3830 Calreticulin CALR 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
751 Potassium channel subfamily K member 6 KCNK6 0.0025
1360 Sphingomyelin phosphodiesterase SMPD1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
1374 Natriuretic peptides B NPPB 0.0025
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0025
1827 Gap junction alpha-1 protein GJA1 0.0025
1908 Vascular cell adhesion protein 1 VCAM1 0.0025
5798 Mitogen-activated protein kinase 11 MAPK11 0.0025
1864 RET proto-oncogene RET 0.0025
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0024
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0024
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
267 Plasminogen activator inhibitor 1 SERPINE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0024
3639 Thymidine phosphorylase deoA 0.0024
3936 Thymidine phosphorylase TYMP 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4773 Deoxycytidine kinase DCK 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3808 Dihydropteroate synthase 2 folP2 0.0023
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0023
3601 Dihydropteroate synthase 1 folP1 0.0023
3807 Dihydropteroate synthase 1 folP1 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
3086 Plasmepsin-2 Not Available 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
2417 Chloramphenicol acetyltransferase cat 0.0023
3278 Chloramphenicol acetyltransferase cat 0.0023
908 Glutathione S-transferase theta-1 GSTT1 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
2810 Dr hemagglutinin structural subunit draA 0.0023
65 Matrix metalloproteinase-9 Not Available 0.0023
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0023
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
1341 Histamine H3 receptor HRH3 0.0023
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0023
172 Potassium channel subfamily K member 1 KCNK1 0.0023
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0023
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0023
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0022
6221 Steroid hormone receptor ERR1 ESRRA 0.0022
3404 Exotoxin A eta 0.0022
896 Glutathione S-transferase Mu 1 GSTM1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0021
162 Retinoic acid receptor gamma-1 RARG 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0021
2091 Endoplasmin HSP90B1 0.0021
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0021
268 Adenosine A2b receptor ADORA2B 0.0021
1852 Microtubule-associated protein 2 MAP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
719 Retinoic acid receptor responder protein 1 RARRES1 0.002
770 Retinoic acid-induced protein 3 GPRC5A 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
1820 Beta-nerve growth factor NGF 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.002
572 Integrin alpha-L ITGAL 0.002
3868 Calcineurin subunit B isoform 2 PPP3R2 0.002
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.002
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
683 Potassium transporter GK0582 0.0018
569 Retinal dehydrogenase 2 ALDH1A2 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6163 Copper-transporting ATPase 2 ATP7B 0.0017
6165 Copper-transporting ATPase 1 ATP7A 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
611 Retinal dehydrogenase 1 ALDH1A1 0.0017
4192 DNA topoisomerase 2-beta TOP2B 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
1243 Cathepsin D CTSD 0.0016
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0015
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0015
6048 Troponin C, skeletal muscle TNNC2 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
2207 Rhodopsin RHO 0.0014
2320 Thymidine kinase, cytosolic TK1 0.0014
6824 Tyrosine-protein kinase Lyn LYN 0.0014
3913 Glutamic acid decarboxylase GAD65 0.0014
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0014
4226 Uridine phosphorylase 2 UPP2 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
6859 Protein S100-A4 S100A4 0.0014
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0014
3917 Methylenetetrahydrofolate reductase MTHFR 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
6218 Pannexin-1 PANX1 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6168 Solute carrier family 22 member 16 SLC22A16 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
4225 Uridine phosphorylase 1 UPP1 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
2021 Thrombomodulin THBD 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
413 Amidophosphoribosyltransferase PPAT 0.0012
2515 Amidophosphoribosyltransferase purF 0.0012
3714 Amidophosphoribosyltransferase purF 0.0012
5924 Microtubule-associated protein 4 MAP4 0.0012
5923 Microtubule-associated protein tau MAPT 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
76 Nitric-oxide synthase, brain NOS1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6033 High affinity interleukin-8 receptor A CXCR1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
4386 Hemoglobin-like protein HbN glbN 0.0009
2298 Cytochrome P450-cam camC 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
489 Monocarboxylate transporter 2 SLC16A7 0.0008
1867 Major prion protein PRNP 0.0008
3221 Cytochrome c4 cc4 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
822 Aldose reductase AKR1B1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1507 Cytochrome c CYCS 0.0007
125 DNA polymerase beta POLB 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4916 Cyanoglobin glbN 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4984 Neuroglobin NGB 0.0006
4943 Cytochrome c6 petJ 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
3116 Bacterioferritin bfr 0.0006
4906 Bacterioferritin bfr 0.0006
4965 Bacterioferritin bfr 0.0006
4910 Cytoglobin CYGB 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
5000 HemO hemO 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4909 CooA protein cooA 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4942 Diheme cytochrome c napB napB 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4961 Hemophore HasA hasA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4972 P450cin cinA 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
3093 Catalase HPII katE 0.0006
4952 Catalase/peroxidase katA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
798 Osteocalcin BGLAP 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
358 Cystathionine beta-synthase CBS 0.0003
693 Hemoglobin subunit beta HBB 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
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