DT-Web

DB00603 - Medroxyprogesterone


Identification
Name Medroxyprogesterone
Accession Number DB00603 (APRD00627)
Type small molecule
Description (6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione. A synthetic progestational hormone used in veterinary practice as an estrus regulator. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 344.4877
Groups approved
Monoisotopic Weight 344.23514489
Pharmacology
Indication Used as a contraceptive and to treat secondary amenorrhea, abnormal uterine bleeding, pain associated with endometriosis, endometrial and renal cell carcinomas, paraphilia in males, GnRH-dependent forms of precocious puberty, as well as to prevent endometrial changes associated with estrogens.
Mechanism of action Progestins diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge.
Absorption Rapidly absorbed from GI tract
Protein binding 90%
Biotransformation Hepatic
Route of elimination Following oral dosing, MPA is extensively metabolized in the liver via hydroxylation, with subsequent conjugation and elimination in the urine. Most MPA metabolites are excreted in the urine as glucuronide conjugates with only minor amounts excreted as sulfates.
Toxicity Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Medroxyprogesterone may increase the anticoagulant effect of acenocoumarol.
Amobarbital The enzyme inducer, amobarbital, decreases the effect of the hormone agent, medroxyprogesterone.
Anisindione Medroxyprogesterone may increase the anticoagulant effect of anisindione.
Aprobarbital The enzyme inducer, aprobarbital, decreases the effect of the hormone agent, medroxyprogesterone.
Artemether Artemether may decrease the effectiveness of medroxyprogesterone by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Bexarotene Bexarotene may decrease the serum concentration of Contraceptives (Progestins). Since bexarotene is teratogenic and can lower serum concentrations of medroxyprogesterone, it is advised that women of childbearing potential use two forms of contraception (including at least one non-hormonal form).
Bosentan Bosentan may decrease the contraceptive effect of medroxyprogesterone. Hormonal contraception should not be relied on alone during concomitant therapy with bosentan.
Butabarbital The enzyme inducer, butabarbital, decreases the effect of the hormone agent, medroxyprogesterone.
Butalbital The enzyme inducer, butalbital, decreases the effect of the hormone agent, medroxyprogesterone.
Butethal The enzyme inducer, butethal, decreases the effect of the hormone agent, medroxyprogesterone.
Colesevelam Bile Acid Sequestrants may decrease the serum concentration of Contraceptives (Progestins). Administer oral progestin-containing contraceptives at least 1-4 hours prior to or 4-6 hours after administration of a bile acid sequestrant. Consider alternatives in order to avoid this combination when possible, due to the risk for impaired contraceptive effectiveness.
Dicumarol Medroxyprogesterone may increase the anticoagulant effect of dicumarol.
Ethotoin The enzyme inducer, ethotoin, decreases the effect of the hormone agent, medroxyprogesterone.
Fosphenytoin The enzyme inducer, fosphenytoin, may decrease the effect of the hormone, medroxyprogesterone.
Griseofulvin The enzyme inducer, griseofulvin, may decrease the effect of the hormone, medroxyprogesterone.
Heptabarbital The enzyme inducer, heptabarbital, decreases the effect of the hormone agent, medroxyprogesterone.
Hexobarbital The enzyme inducer, hexobarbital, decreases the effect of the hormone agent, medroxyprogesterone.
Mephenytoin The enzyme inducer, mephenytoin, decreases the effect of the hormone agent, medroxyprogesterone.
Methohexital The enzyme inducer, methohexital, decreases the effect of the hormone agent, medroxyprogesterone.
Methylphenobarbital The enzyme inducer, methylphenobarbital, decreases the effect of the hormone agent, medroxyprogesterone.
Pentobarbital The enzyme inducer, pentobarbital, decreases the effect of the hormone agent, medroxyprogesterone.
Phenobarbital The enzyme inducer, phenobarbital, may decrease the effect of the hormone, medroxyprogesterone.
Phenytoin The enzyme inducer, phenytoin, may decrease the effect of medroxyprogesterone.
Primidone The enzyme inducer, primidone, may decrease the effect of the hormone, medroxyprogesterone.
Secobarbital The enzyme inducer, secobarbital, decreases the effect of the hormone agent, medroxyprogesterone.
Talbutal The enzyme inducer, talbutal, decreases the effect of the hormone agent, medroxyprogesterone.
Thiopental Thiopental may decrease the effect of Medroxyprogesterone. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Warfarin Medroxyprogesterone may alter the anticoagulant effect of warfarin. Concomitant therapy should be avoided. Monitor for changes in coagulation status if medroxyprogesterone is initiated, discontinued or dose changed.
Food Interactions
  • Take with food.

Targets


Progesterone receptor
Name Progesterone receptor
Gene Name PGR
Pharmacological action yes
Actions agonist
References
  • Risch HA, Bale AE, Beck PA, Zheng W: PGR +331 A/G and increased risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1738-41. - Pubmed
  • Madauss KP, Stewart EL, Williams SP: The evolution of progesterone receptor ligands. Med Res Rev. 2007 May;27(3):374-400. - Pubmed
  • Gizard F, Robillard R, Gross B, Barbier O, Revillion F, Peyrat JP, Torpier G, Hum DW, Staels B: TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone. Mol Cell Biol. 2006 Oct;26(20):7632-44. - Pubmed
  • Wu HB, Fabian S, Jenab S, Quinones-Jenab V: Progesterone receptors activation after acute cocaine administration. Brain Res. 2006 Dec 18;1126(1):188-92. Epub 2006 Nov 15. - Pubmed
  • Boonyaratanakornkit V, McGowan E, Sherman L, Mancini MA, Cheskis BJ, Edwards DP: The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle. Mol Endocrinol. 2007 Feb;21(2):359-75. Epub 2006 Nov 30. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6824
Estrogen receptor
Name Estrogen receptor
Gene Name ESR1
Pharmacological action yes
Actions agonist
References
  • Jain JK, Li A, Yang W, Minoo P, Felix JC: Mifepristone alters expression of endometrial steroid receptors and their cofactors in new users of medroxyprogesterone acetate. Fertil Steril. 2007 Jan;87(1):8-23. Epub 2006 Nov 7. - Pubmed
  • Kumar AS, Cureton E, Shim V, Sakata T, Moore DH, Benz CC, Esserman LJ, Hwang ES: Type and duration of exogenous hormone use affects breast cancer histology. Ann Surg Oncol. 2007 Feb;14(2):695-703. Epub 2006 Nov 14. - Pubmed
  • Lessey BA, Palomino WA, Apparao K, Young SL, Lininger RA: Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women. Reprod Biol Endocrinol. 2006 Oct 9;4 Suppl 1:S9. - Pubmed
  • Yuri T, Tsukamoto R, Uehara N, Matsuoka Y, Tsubura A: Effects of different durations of estrogen and progesterone treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats. In Vivo. 2006 Nov-Dec;20(6B):829-36. - Pubmed
  • Ghebeh H, Tulbah A, Mohammed S, Elkum N, Bin Amer SM, Al-Tweigeri T, Dermime S: Expression of B7-H1 in breast cancer patients is strongly associated with high proliferative Ki-67-expressing tumor cells. Int J Cancer. 2007 Aug 15;121(4):751-8. - Pubmed
DTHybrid score 0.9123

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inducer
References
  • Zhang JW, Liu Y, Zhao JY, Wang LM, Ge GB, Gao Y, Li W, Liu HT, Liu HX, Zhang YY, Sun J, Yang L: Metabolic profiling and cytochrome P450 reaction phenotyping of medroxyprogesterone acetate. Drug Metab Dispos. 2008 Nov;36(11):2292-8. Epub 2008 Aug 25. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4793
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2779
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
Name 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
Gene Name HSD3B2
Actions inhibitor
References
  • Lee TC, Miller WL, Auchus RJ: Medroxyprogesterone acetate and dexamethasone are competitive inhibitors of different human steroidogenic enzymes. J Clin Endocrinol Metab. 1999 Jun;84(6):2104-10. - Pubmed
DTHybrid score 0.3144
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3585

Predictions


Id Partner name Gene Name Score
6241 Nuclear receptor coactivator 2 NCOA2 0.2512
6016 Cytochrome P450 2C19 CYP2C19 0.1731
1588 Multidrug resistance protein 1 ABCB1 0.1569
4119 Cytochrome P450 2D6 CYP2D6 0.1562
869 Estrogen receptor beta ESR2 0.1386
4200 Cytochrome P450 1A2 CYP1A2 0.1293
4118 Cytochrome P450 3A5 CYP3A5 0.1256
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.1197
945 Adrenocorticotropic hormone receptor MC2R 0.0978
6107 Cytochrome P450 3A7 CYP3A7 0.0944
6030 Cytochrome P450 2B6 CYP2B6 0.0944
6013 Cytochrome P450 2E1 CYP2E1 0.0791
1566 Corticoliberin CRH 0.0717
146 Androgen receptor AR 0.0705
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.0693
3811 Cytochrome P450 19A1 CYP19A1 0.0668
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0651
587 Serum albumin ALB 0.0643
20 Prostaglandin G/H synthase 1 PTGS1 0.064
871 Glucocorticoid receptor NR3C1 0.0616
6024 Cytochrome P450 1A1 CYP1A1 0.0578
5718 Cytochrome P450 2A6 CYP2A6 0.0574
2202 Steryl-sulfatase STS 0.0552
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0539
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0478
290 Prostaglandin G/H synthase 2 PTGS2 0.0446
756 Sex hormone-binding globulin SHBG 0.0394
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0365
862 Multidrug resistance-associated protein 1 ABCC1 0.0363
737 Mineralocorticoid receptor NR3C2 0.036
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0354
6106 Cytochrome P450 2C18 CYP2C18 0.0337
1729 Solute carrier family 22 member 6 SLC22A6 0.0276
1898 Cytochrome P450 1B1 CYP1B1 0.0272
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0272
492 Histamine H1 receptor HRH1 0.0265
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0262
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0257
776 Bile salt export pump ABCB11 0.0238
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0212
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0207
6145 Solute carrier family 22 member 1 SLC22A1 0.0203
824 Sodium-dependent serotonin transporter SLC6A4 0.02
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0191
6142 Solute carrier family 22 member 8 SLC22A8 0.0188
2164 Multidrug resistance-associated protein 4 ABCC4 0.0185
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0183
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0182
220 Sodium channel protein type 5 subunit alpha SCN5A 0.018
1649 Small inducible cytokine A2 CCL2 0.018
847 Mu-type opioid receptor OPRM1 0.0179
502 5-hydroxytryptamine 2A receptor HTR2A 0.0175
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0173
232 Corticosteroid-binding globulin SERPINA6 0.0169
467 Delta-type opioid receptor OPRD1 0.0168
6144 Solute carrier family 22 member 2 SLC22A2 0.0164
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0163
731 HIV-1 protease HIV-1 protease 0.0163
6141 Sodium/bile acid cotransporter SLC10A1 0.0161
696 Kappa-type opioid receptor OPRK1 0.0158
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0155
3923 Cholinesterase BCHE 0.0153
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0152
226 Gonadotropin-releasing hormone receptor GNRHR 0.015
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0146
891 Dihydropteroate synthase folP 0.0146
5359 Dihydropteroate synthase folP 0.0146
7175 Dihydropteroate synthase sulI 0.0146
831 D(2) dopamine receptor DRD2 0.0146
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0137
556 Alpha-1A adrenergic receptor ADRA1A 0.0136
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0135
380 Cytochrome P450 17A1 CYP17A1 0.0135
468 Cytochrome P450 4A11 CYP4A11 0.0135
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0135
6143 Solute carrier family 22 member 7 SLC22A7 0.0134
122 P2Y purinoceptor 12 P2RY12 0.0134
617 Muscarinic acetylcholine receptor M2 CHRM2 0.013
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0129
260 Cytochrome P450 51 ERG11 0.0129
761 Cytochrome P450 51 ERG11 0.0129
3163 Cytochrome P450 51 cyp51 0.0129
341 5-hydroxytryptamine 3 receptor HTR3A 0.0129
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0127
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0127
1024 Solute carrier family 22 member 11 SLC22A11 0.0126
70 Type-1 angiotensin II receptor AGTR1 0.0126
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0124
6228 Nuclear receptor coactivator 1 NCOA1 0.0122
318 Alpha-2A adrenergic receptor ADRA2A 0.0121
6147 Solute carrier family 22 member 3 SLC22A3 0.012
723 Cytosolic phospholipase A2 PLA2G4A 0.0119
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0118
6031 Cytochrome P450 3A43 CYP3A43 0.0118
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0118
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0116
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0114
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0114
590 5-hydroxytryptamine 2C receptor HTR2C 0.0112
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0111
6182 Cytochrome P450 2J2 CYP2J2 0.0106
118 Organic cation/carnitine transporter 2 SLC22A5 0.0104
713 Sodium-dependent dopamine transporter SLC6A3 0.0103
320 5-hydroxytryptamine 1A receptor HTR1A 0.0102
632 Alpha-1B adrenergic receptor ADRA1B 0.0101
274 Muscarinic acetylcholine receptor M5 CHRM5 0.01
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.01
811 Translocator protein TSPO 0.01
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.01
6020 Aldehyde oxidase AOX1 0.0099
23 D(1A) dopamine receptor DRD1 0.0099
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0098
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
766 Beta-2 adrenergic receptor ADRB2 0.0095
465 Calmodulin CALM1 0.0094
381 Prolactin receptor PRLR 0.0093
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0093
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0092
3941 Amine oxidase [flavin-containing] A MAOA 0.0092
365 Dihydrofolate reductase DHFR 0.0091
2381 Dihydrofolate reductase DFR1 0.0091
2833 Dihydrofolate reductase Not Available 0.0091
2931 Dihydrofolate reductase folA 0.0091
3544 Dihydrofolate reductase folA 0.0091
3682 Dihydrofolate reductase folA 0.0091
6642 Dihydrofolate reductase folA 0.0091
6756 Dihydrofolate reductase dfrA 0.0091
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.009
3810 Catechol O-methyltransferase COMT 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
817 DNA topoisomerase 2-alpha TOP2A 0.0088
2107 Microtubule-associated protein 1A MAP1A 0.0087
373 Transthyretin TTR 0.0086
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0085
6102 Arylamine N-acetyltransferase 2 NAT2 0.0084
1852 Microtubule-associated protein 2 MAP2 0.0083
29 Tubulin beta-1 chain TUBB1 0.0081
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0081
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0078
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0077
4604 Liver carboxylesterase 1 CES1 0.0076
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0076
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0075
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0075
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0075
504 Mast/stem cell growth factor receptor KIT 0.0074
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0074
1541 Metalloproteinase mmp20 0.0074
6136 Multidrug resistance-associated protein 5 ABCC5 0.0073
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0073
3939 Amine oxidase [flavin-containing] B MAOB 0.0072
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
789 Alpha-1D adrenergic receptor ADRA1D 0.0072
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0072
6085 Fatty acid-binding protein, intestinal FABP2 0.0071
6148 Multidrug resistance-associated protein 7 ABCC10 0.007
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.007
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0069
49 Endothelin B receptor EDNRB 0.0069
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0068
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0068
844 Epidermal growth factor receptor EGFR 0.0068
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0068
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0068
295 Carbonic anhydrase 1 CA1 0.0068
952 Dipeptidyl peptidase 4 DPP4 0.0067
885 5-hydroxytryptamine 1B receptor HTR1B 0.0067
407 Vascular endothelial growth factor receptor 2 KDR 0.0067
592 Carbonic anhydrase 4 CA4 0.0067
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0066
6137 Multidrug resistance-associated protein 6 ABCC6 0.0066
578 Endothelin-1 receptor EDNRA 0.0065
833 Organic cation/carnitine transporter 1 SLC22A4 0.0064
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0064
1757 Myeloperoxidase MPO 0.0064
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0063
133 Dihydropterate synthase sulI 0.0063
638 D(3) dopamine receptor DRD3 0.0063
629 Alpha-2B adrenergic receptor ADRA2B 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0061
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.006
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.006
725 5-hydroxytryptamine 1D receptor HTR1D 0.006
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
571 Melatonin receptor type 1A MTNR1A 0.0059
362 Melatonin receptor type 1B MTNR1B 0.0059
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0058
818 50S ribosomal protein L10 rplJ 0.0058
275 Arachidonate 5-lipoxygenase ALOX5 0.0058
3809 Estrogen-related receptor gamma ESRRG 0.0058
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0058
88 Retinoic acid receptor RXR-beta RXRB 0.0057
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0057
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0057
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0057
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0056
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0056
427 Substance-P receptor TACR1 0.0056
777 Tumor necrosis factor TNF 0.0056
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0056
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0056
24 Thymidylate synthase TMP1 0.0055
359 Thymidylate synthase TYMS 0.0055
2626 Thymidylate synthase thyA 0.0055
2729 Thymidylate synthase thyA 0.0055
5352 Thymidylate synthase THYA 0.0055
4120 NADPH--cytochrome P450 reductase POR 0.0055
4210 Toll-like receptor 4 TLR4 0.0054
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0054
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0053
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0053
94 5-hydroxytryptamine 4 receptor HTR4 0.0053
1291 cAMP response element-binding protein CREB1 0.0052
161 Tubulin beta chain TUBB 0.0052
312 Tubulin beta chain TUB2 0.0052
193 Beta-1 adrenergic receptor ADRB1 0.0052
436 5-hydroxytryptamine 2B receptor HTR2B 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0051
378 Alpha-2C adrenergic receptor ADRA2C 0.005
992 Protein tyrosine kinase 2 beta PTK2B 0.005
357 Carbonic anhydrase 2 CA2 0.005
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0049
1010 Cytochrome P450 51A1 CYP51A1 0.0049
856 Vitamin D3 receptor VDR 0.0049
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0048
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0048
814 Ryanodine receptor 1 RYR1 0.0048
6220 Aryl hydrocarbon receptor AHR 0.0047
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0047
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0046
1648 Elastin ELN 0.0046
3947 Xanthine dehydrogenase/oxidase XDH 0.0046
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0046
6014 Cytochrome P450 2A13 CYP2A13 0.0046
68 Cannabinoid receptor 1 CNR1 0.0046
26 Vascular endothelial growth factor receptor 3 FLT4 0.0046
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0046
527 Prostacyclin receptor PTGIR 0.0045
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0045
1275 Estrogen sulfotransferase SULT1E1 0.0045
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0045
228 Beta platelet-derived growth factor receptor PDGFRB 0.0045
474 Acetylcholinesterase ACHE 0.0045
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0045
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
432 D(4) dopamine receptor DRD4 0.0044
130 Prostacyclin synthase PTGIS 0.0044
32 Vascular endothelial growth factor receptor 1 FLT1 0.0044
1050 Bile salt sulfotransferase SULT2A1 0.0044
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0044
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0043
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0043
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0043
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0042
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0042
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0042
738 Monocarboxylate transporter 1 SLC16A1 0.0042
716 5-hydroxytryptamine 7 receptor HTR7 0.0041
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0041
1192 Sulfotransferase 1A1 SULT1A1 0.0041
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
1629 Transcription factor AP-1 JUN 0.004
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.004
921 Glutamate receptor 2 GRIA2 0.004
780 Retinoic acid receptor RXR-gamma RXRG 0.0039
6138 Multidrug resistance protein 3 ABCB4 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
569 Retinal dehydrogenase 2 ALDH1A2 0.0039
6126 Carbonic anhydrase 7 CA7 0.0038
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
284 DNA-directed RNA polymerase beta chain rpoB 0.0037
5773 DNA-directed RNA polymerase beta chain rpoB 0.0037
54 Prothrombin F2 0.0037
4122 Histone deacetylase 2 HDAC2 0.0037
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0036
1656 CYP2B protein CYP2B 0.0036
482 Glycine receptor subunit alpha-1 GLRA1 0.0036
611 Retinal dehydrogenase 1 ALDH1A1 0.0036
558 Solute carrier family 12 member 1 SLC12A1 0.0036
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0036
16 Adenosine A1 receptor ADORA1 0.0036
4237 50S ribosomal protein L22 rplV 0.0035
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
6149 Solute carrier family 22 member 10 SLC22A10 0.0035
2539 Tubulin alpha-1 chain TUBA4A 0.0035
518 Peroxidase/catalase T katG 0.0035
1178 Adenosine A2a receptor ADORA2A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0035
124 Histamine H2 receptor HRH2 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0034
5300 Antigen peptide transporter 1 TAP1 0.0034
581 Cytochrome P450 2R1 CYP2R1 0.0034
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0033
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0033
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0033
183 Vascular endothelial growth factor A VEGFA 0.0033
3830 Calreticulin CALR 0.0033
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0033
5880 Thrombopoietin receptor MPL 0.0033
162 Retinoic acid receptor gamma-1 RARG 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
3932 Glutathione S-transferase A2 GSTA2 0.0032
6174 50S ribosomal protein L32 rpmF 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
1196 Complement decay-accelerating factor CD55 0.0031
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0031
3086 Plasmepsin-2 Not Available 0.0031
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0031
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0031
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0031
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0031
6035 Nuclear receptor ROR-beta RORB 0.0031
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0031
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0031
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0031
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0031
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0031
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0031
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0031
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0031
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0031
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0031
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0031
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0031
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0031
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0031
6034 Hydroxyindole O-methyltransferase ASMT 0.0031
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0031
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0031
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0031
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0031
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0031
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0031
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0031
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0031
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0031
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0031
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0031
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0031
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0031
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0031
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0031
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0031
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0031
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0031
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0031
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0031
6036 Eosinophil peroxidase EPX 0.0031
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0031
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0031
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0031
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0031
729 GDP-L-fucose synthetase TSTA3 0.0031
3463 GDP-L-fucose synthetase fcl 0.0031
167 L-lactate dehydrogenase C chain LDHC 0.0031
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0031
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0031
206 3-keto-steroid reductase HSD17B7 0.0031
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0031
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0031
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0031
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0031
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0031
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0031
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0031
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0031
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0031
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0031
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0031
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0031
643 Peroxisomal bifunctional enzyme EHHADH 0.0031
711 UDP-glucose 6-dehydrogenase UGDH 0.0031
3672 UDP-glucose 6-dehydrogenase hasB 0.0031
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0031
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0031
107 C-4 methylsterol oxidase SC4MOL 0.0031
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0031
3726 D-3-phosphoglycerate dehydrogenase serA 0.0031
4291 D-3-phosphoglycerate dehydrogenase serA 0.0031
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0031
644 Heme oxygenase 2 HMOX2 0.0031
4982 Heme oxygenase 2 pbsA2 0.0031
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0031
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0031
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0031
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0031
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0031
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0031
34 7-dehydrocholesterol reductase DHCR7 0.0031
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0031
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.003
705 Glutamate receptor 1 GRIA1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
251 Alcohol dehydrogenase 1A ADH1A 0.003
816 Biliverdin reductase A BLVRA 0.003
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.003
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.003
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.003
823 Fibroblast growth factor receptor 2 FGFR2 0.003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.003
473 L-lactate dehydrogenase A chain LDHA 0.0029
153 Dopamine beta-hydroxylase DBH 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
634 Squalene monooxygenase SQLE 0.0028
7196 Squalene monooxygenase ERG1 0.0028
1618 High affinity nerve growth factor receptor NTRK1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0027
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0027
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0027
2808 Chloramphenicol acetyltransferase 3 cat3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
84 Nuclear receptor 0B1 NR0B1 0.0027
5787 Angiopoietin-1 receptor TEK 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0027
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0027
469 Annexin A1 ANXA1 0.0027
239 Coagulation factor X F10 0.0027
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0027
444 Alcohol dehydrogenase 1B ADH1B 0.0027
163 D(1B) dopamine receptor DRD5 0.0027
765 Indoleamine 2,3-dioxygenase IDO1 0.0027
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0026
273 Apoptosis regulator Bcl-2 BCL2 0.0026
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0026
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0026
646 Malate dehydrogenase, cytoplasmic MDH1 0.0026
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0026
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0026
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0026
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0026
666 NADP-dependent malic enzyme ME1 0.0026
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0026
396 Alcohol dehydrogenase 4 ADH4 0.0026
3856 Fibroblast growth factor receptor 3 FGFR3 0.0026
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0026
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0026
6026 Alcohol dehydrogenase 6 ADH6 0.0025
328 Sorbitol dehydrogenase SORD 0.0025
597 Dihydropteridine reductase QDPR 0.0025
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0025
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0025
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
165 FL cytokine receptor FLT3 0.0025
528 5-hydroxytryptamine 1E receptor HTR1E 0.0025
627 11-cis retinol dehydrogenase RDH5 0.0025
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0025
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0025
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0025
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
3808 Dihydropteroate synthase 2 folP2 0.0025
3601 Dihydropteroate synthase 1 folP1 0.0025
3807 Dihydropteroate synthase 1 folP1 0.0025
626 Cysteine dioxygenase type 1 CDO1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
857 Malate dehydrogenase, mitochondrial MDH2 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
1256 5-hydroxytryptamine 6 receptor HTR6 0.0024
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
2112 Toll-like receptor 9 TLR9 0.0024
229 Retinoic acid receptor beta RARB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0024
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0024
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0023
730 Retinoic acid receptor alpha RARA 0.0023
77 L-lactate dehydrogenase B chain LDHB 0.0023
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0023
12 Alcohol dehydrogenase class 3 ADH5 0.0023
6146 High affinity copper uptake protein 1 SLC31A1 0.0023
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0023
517 Alcohol dehydrogenase 1C ADH1C 0.0023
13 Aminomethyltransferase, mitochondrial AMT 0.0023
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0023
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0022
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0022
2981 Phospholipase A2, membrane associated PLA2G2A 0.0022
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0022
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0022
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0022
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0022
4311 tRNA TRDMT1 0.0022
4325 tRNA trmD 0.0022
4328 tRNA trmD 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
1992 Vitamin D-binding protein GC 0.0022
164 Histamine H4 receptor HRH4 0.0022
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0022
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0022
319 Opioid receptor, sigma 1 OPRS1 0.0022
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0022
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
2232 Interleukin-5 IL5 0.0022
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0021
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0021
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
279 Tyrosinase TYR 0.0021
976 Platelet glycoprotein IX GP9 0.0021
1630 Integrin beta-2 ITGB2 0.0021
4103 Proteasome subunit beta type 2 PSMB2 0.0021
4102 Proteasome subunit beta type 5 PSMB5 0.0021
4101 Proteasome subunit beta type 1 PSMB1 0.0021
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0021
594 Thyroxine-binding globulin SERPINA7 0.002
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.002
166 NAD-dependent malic enzyme, mitochondrial ME2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
810 Heme oxygenase 1 HMOX1 0.002
3391 Heme oxygenase 1 pbsA1 0.002
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.002
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.002
4217 Telomerase reverse transcriptase TERT 0.002
904 Glutathione S-transferase P GSTP1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0019
654 Flavin reductase BLVRB 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0018
174 Sigma 1-type opioid receptor SIGMAR1 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
537 ATP synthase delta chain, mitochondrial ATP5D 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
1262 Corticotropin-lipotropin POMC 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
6048 Troponin C, skeletal muscle TNNC2 0.0018
683 Potassium transporter GK0582 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
719 Retinoic acid receptor responder protein 1 RARRES1 0.0017
770 Retinoic acid-induced protein 3 GPRC5A 0.0017
268 Adenosine A2b receptor ADORA2B 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0017
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0017
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0017
106 Cannabinoid receptor 2 CNR2 0.0017
6044 Serum paraoxonase/lactonase 3 PON3 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
4773 Deoxycytidine kinase DCK 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
714 Glutathione reductase, mitochondrial GSR 0.0017
3937 Fatty-acid amide hydrolase FAAH 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0016
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0016
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
563 Thyroid peroxidase TPO 0.0016
572 Integrin alpha-L ITGAL 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0016
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0016
5798 Mitogen-activated protein kinase 11 MAPK11 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0016
3233 Bile acid receptor NR1H4 0.0015
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0015
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0015
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0015
936 Ephrin type-A receptor 2 EPHA2 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
267 Plasminogen activator inhibitor 1 SERPINE1 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
489 Monocarboxylate transporter 2 SLC16A7 0.0014
1341 Histamine H3 receptor HRH3 0.0014
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0014
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0014
7 Nitric oxide synthase, inducible NOS2 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0014
6221 Steroid hormone receptor ERR1 ESRRA 0.0014
6218 Pannexin-1 PANX1 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
5934 Cytochrome P450 26A1 CYP26A1 0.0014
822 Aldose reductase AKR1B1 0.0014
751 Potassium channel subfamily K member 6 KCNK6 0.0013
1039 Histone deacetylase 9 HDAC9 0.0013
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0013
2021 Thrombomodulin THBD 0.0013
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
2207 Rhodopsin RHO 0.0013
908 Glutathione S-transferase theta-1 GSTT1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
4192 DNA topoisomerase 2-beta TOP2B 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0012
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0012
605 Fumarate reductase flavoprotein subunit frdA 0.0012
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0012
3673 Fumarate reductase flavoprotein subunit fccA 0.0012
4912 Fumarate reductase flavoprotein subunit ifcA 0.0012
6549 Fumarate reductase flavoprotein subunit frdA 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0012
3957 Adenosine deaminase ADA 0.0011
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0011
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
1374 Natriuretic peptides B NPPB 0.0011
1827 Gap junction alpha-1 protein GJA1 0.0011
1908 Vascular cell adhesion protein 1 VCAM1 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
3917 Methylenetetrahydrofolate reductase MTHFR 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
5251 Carbonyl reductase [NADPH] 1 CBR1 0.001
511 5-hydroxytryptamine 1F receptor HTR1F 0.001
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
760 Fibroblast growth factor 1 FGF1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
1517 Beta-3 adrenergic receptor ADRB3 0.0009
820 Glycine receptor subunit alpha-2 GLRA2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
6677 Myelin P2 protein PMP2 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
33 Cystine/glutamate transporter SLC7A11 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
3404 Exotoxin A eta 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
2298 Cytochrome P450-cam camC 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
1864 RET proto-oncogene RET 0.0008
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0008
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0008
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
6432 Transporter snf 0.0008
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0008
1025 Aquaporin-1 AQP1 0.0008
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0008
1268 Neuropeptide S receptor NPSR1 0.0008
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0008
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0008
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0008
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0008
2091 Endoplasmin HSP90B1 0.0008
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0008
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0008
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
3221 Cytochrome c4 cc4 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0007
6072 Potassium channel subfamily K member 3 KCNK3 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
1507 Cytochrome c CYCS 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0005
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4916 Cyanoglobin glbN 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4943 Cytochrome c6 petJ 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
5000 HemO hemO 0.0005
4984 Neuroglobin NGB 0.0005
4909 CooA protein cooA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4910 Cytoglobin CYGB 0.0005
4961 Hemophore HasA hasA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4972 P450cin cinA 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
1360 Sphingomyelin phosphodiesterase SMPD1 0.0003
358 Cystathionine beta-synthase CBS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
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