DT-Web

DB01224 - Quetiapine


Identification
Name Quetiapine
Accession Number DB01224 (APRD00675)
Type small molecule
Description Quetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 383.507
Groups approved
Monoisotopic Weight 383.166747749
Pharmacology
Indication For the treatment of schizophrenia and related psychotic disorders.
Mechanism of action Quetiapine's antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. Antagonism at D2 receptors relieves positive symptoms while antagonism at 5HT2A receptors relieves negative symptoms of schizophrenia.
Absorption Rapidly and well absorbed.
Protein binding 83%
Biotransformation Hepatic. The major metabolic pathways are sulfoxidation, mediated by cytochrome P450 3A4 (CYP3A4), and oxidation of the terminal alcohol to a carboxylic acid. The major sulfoxide metabolite of quetiapine is inactive. Quetiapine also undergoes hydroxylation of the dibenzothiazepine ring, O-deakylation, N-dealkylation, and phase II conjugation. The 7-hydroxy and 7-hydroxy- N-delakylated metabolites appear to be active, but are present in very low concentrations.
Route of elimination Elimination of quetiapine is mainly via hepatic metabolism. Following a single oral dose of 14C-quetiapine, less than 1% of the administered dose was excreted as unchanged drug, indicating that quetiapine is highly metabolized. Approximately 73% and 20% of the dose was recovered in the urine and feces, respectively.
Toxicity Symptoms of overdose include drowsiness and sedation, tachycardia, and hypotension.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Clarithromycin The macrolide, clarithromycin, may increase the effect and toxicity of quetiapine.
Donepezil Possible antagonism of action
Erythromycin The macrolide, erythromycin, may increase the effect and toxicity of quetiapine.
Ethotoin Phenytoin decreases the effect of quetiapine
Etravirine Quetiapine, when used concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration. It is recommended to increase quetiapine dosage if concurrent therapy is required.
Fosphenytoin Phenytoin decreases the effect of quetiapine
Galantamine Possible antagonism of action
Ketoconazole Ketoconazole may increase the therapeutic and adverse effects of quetiapine.
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mephenytoin Phenytoin decreases the effect of quetiapine
Phenytoin Phenytoin decreases the effect of quetiapine
Quinupristin This combination presents an increased risk of toxicity
Rivastigmine Possible antagonism of action
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Quetiapine, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents.
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Telithromycin Telithromycin may reduce clearance of Quetiapine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Quetiapine if Telithromycin is initiated, discontinued or dose changed.
Tetrabenazine May cause dopamine deficiency. Monitor for Tetrabenazine adverse effects.
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trimethobenzamide Trimethobenzamide and Quetiapine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Triprolidine Triprolidine and Quetiapine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium Trospium and Quetiapine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of quetiapine by decreasing its metabolism. Additive QTc prolongation may also occur. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of quetiapine if voriconazole is initiated, discontinued or dose changed.
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Take without regard to meals.
  • Avoid alcohol.

Targets


5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions antagonist
References
  • Goldstein JM: Quetiapine fumarate (Seroquel): a new atypical antipsychotic. Drugs Today (Barc). 1999 Mar;35(3):193-210. - Pubmed
  • McIntyre RS, Soczynska JK, Woldeyohannes HO, Alsuwaidan M, Konarski JZ: A preclinical and clinical rationale for quetiapine in mood syndromes. Expert Opin Pharmacother. 2007 Jun;8(9):1211-9. - Pubmed
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Yatham LN, Goldstein JM, Vieta E, Bowden CL, Grunze H, Post RM, Suppes T, Calabrese JR: Atypical antipsychotics in bipolar depression: potential mechanisms of action. J Clin Psychiatry. 2005;66 Suppl 5:40-8. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.1243
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Kapur S, Zipursky R, Jones C, Shammi CS, Remington G, Seeman P: A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy. Arch Gen Psychiatry. 2000 Jun;57(6):553-9. - Pubmed
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.1598
5-hydroxytryptamine 1A receptor
Name 5-hydroxytryptamine 1A receptor
Gene Name HTR1A
Pharmacological action unknown
Actions antagonist
References
  • Ichikawa J, Li Z, Dai J, Meltzer HY: Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. Brain Res. 2002 Nov 29;956(2):349-57. - Pubmed
  • McIntyre RS, Soczynska JK, Woldeyohannes HO, Alsuwaidan M, Konarski JZ: A preclinical and clinical rationale for quetiapine in mood syndromes. Expert Opin Pharmacother. 2007 Jun;8(9):1211-9. - Pubmed
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Wood MD, Scott C, Clarke K, Cato KJ, Patel N, Heath J, Worby A, Gordon L, Campbell L, Riley G, Davies CH, Gribble A, Jones DN: Pharmacological profile of antipsychotics at monoamine receptors: atypicality beyond 5-HT2A receptor blockade. CNS Neurol Disord Drug Targets. 2006 Aug;5(4):445-52. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.9124
5-hydroxytryptamine 1B receptor
Name 5-hydroxytryptamine 1B receptor
Gene Name HTR1B
Pharmacological action unknown
Actions other/unknown
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.6965
5-hydroxytryptamine 1D receptor
Name 5-hydroxytryptamine 1D receptor
Gene Name HTR1D
Pharmacological action unknown
Actions other/unknown
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.6822
5-hydroxytryptamine 1E receptor
Name 5-hydroxytryptamine 1E receptor
Gene Name HTR1E
Pharmacological action unknown
Actions other/unknown
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.2702
5-hydroxytryptamine 2C receptor
Name 5-hydroxytryptamine 2C receptor
Gene Name HTR2C
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7951
5-hydroxytryptamine 3 receptor
Name 5-hydroxytryptamine 3 receptor
Gene Name HTR3A
Pharmacological action unknown
Actions other/unknown
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.3834
5-hydroxytryptamine 6 receptor
Name 5-hydroxytryptamine 6 receptor
Gene Name HTR6
Pharmacological action unknown
Actions other/unknown
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.3872
5-hydroxytryptamine 7 receptor
Name 5-hydroxytryptamine 7 receptor
Gene Name HTR7
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.508
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.9748
D(1B) dopamine receptor
Name D(1B) dopamine receptor
Gene Name DRD5
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.5978
D(3) dopamine receptor
Name D(3) dopamine receptor
Gene Name DRD3
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7387
D(4) dopamine receptor
Name D(4) dopamine receptor
Gene Name DRD4
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7009
Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.013
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.1107
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.8104
Alpha-1D adrenergic receptor
Name Alpha-1D adrenergic receptor
Gene Name ADRA1D
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
DTHybrid score 0.5321
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.0601
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.8033
Alpha-2C adrenergic receptor
Name Alpha-2C adrenergic receptor
Gene Name ADRA2C
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7967
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.1771
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.02
Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.0124
Muscarinic acetylcholine receptor M4
Name Muscarinic acetylcholine receptor M4
Gene Name CHRM4
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7973
Muscarinic acetylcholine receptor M5
Name Muscarinic acetylcholine receptor M5
Gene Name CHRM5
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7043

Enzymes


Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.6102
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.4804
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Urichuk L, Prior TI, Dursun S, Baker G: Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions. Curr Drug Metab. 2008 Jun;9(5):410-8. - Pubmed
  • DeVane CL, Nemeroff CB: Clinical pharmacokinetics of quetiapine: an atypical antipsychotic. Clin Pharmacokinet. 2001;40(7):509-22. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.3048
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5873
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.2232

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Boulton DW, DeVane CL, Liston HL, Markowitz JS: In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci. 2002 May 31;71(2):163-9. - Pubmed
DTHybrid score 0.7685

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.6985
4757 Cytochrome P450 2C9 CYP2C9 0.5025
436 5-hydroxytryptamine 2B receptor HTR2B 0.434
4924 Cytochrome P450 2C8 CYP2C8 0.2954
540 Sodium-dependent noradrenaline transporter SLC6A2 0.2873
6013 Cytochrome P450 2E1 CYP2E1 0.283
824 Sodium-dependent serotonin transporter SLC6A4 0.2586
6030 Cytochrome P450 2B6 CYP2B6 0.2577
6145 Solute carrier family 22 member 1 SLC22A1 0.2248
1181 Alpha-1-acid glycoprotein 1 ORM1 0.2117
766 Beta-2 adrenergic receptor ADRB2 0.1883
193 Beta-1 adrenergic receptor ADRB1 0.1846
713 Sodium-dependent dopamine transporter SLC6A3 0.1758
3941 Amine oxidase [flavin-containing] A MAOA 0.1735
587 Serum albumin ALB 0.1682
6024 Cytochrome P450 1A1 CYP1A1 0.1631
6144 Solute carrier family 22 member 2 SLC22A2 0.1613
3923 Cholinesterase BCHE 0.1576
5718 Cytochrome P450 2A6 CYP2A6 0.1487
511 5-hydroxytryptamine 1F receptor HTR1F 0.1478
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.133
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.1193
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1039
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0959
118 Organic cation/carnitine transporter 2 SLC22A5 0.0949
174 Sigma 1-type opioid receptor SIGMAR1 0.0946
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0941
6147 Solute carrier family 22 member 3 SLC22A3 0.0922
124 Histamine H2 receptor HRH2 0.0912
131 Synaptic vesicular amine transporter SLC18A2 0.0823
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0818
20 Prostaglandin G/H synthase 1 PTGS1 0.0813
465 Calmodulin CALM1 0.0793
6106 Cytochrome P450 2C18 CYP2C18 0.0779
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0746
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0737
1517 Beta-3 adrenergic receptor ADRB3 0.0724
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0717
94 5-hydroxytryptamine 4 receptor HTR4 0.0697
847 Mu-type opioid receptor OPRM1 0.0663
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0643
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0642
696 Kappa-type opioid receptor OPRK1 0.0622
833 Organic cation/carnitine transporter 1 SLC22A4 0.0621
1898 Cytochrome P450 1B1 CYP1B1 0.0595
862 Multidrug resistance-associated protein 1 ABCC1 0.0563
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.055
467 Delta-type opioid receptor OPRD1 0.0526
3939 Amine oxidase [flavin-containing] B MAOB 0.0498
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0487
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0478
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0477
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0467
474 Acetylcholinesterase ACHE 0.046
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0458
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0458
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0456
776 Bile salt export pump ABCB11 0.0455
164 Histamine H4 receptor HRH4 0.0455
828 Phenylalanine-4-hydroxylase PAH 0.0449
3109 Phenylalanine-4-hydroxylase phhA 0.0449
3811 Cytochrome P450 19A1 CYP19A1 0.0427
1656 CYP2B protein CYP2B 0.042
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0418
1729 Solute carrier family 22 member 6 SLC22A6 0.0412
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0409
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0407
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0402
6070 Nischarin NISCH 0.0397
871 Glucocorticoid receptor NR3C1 0.0396
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0389
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0389
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0381
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0376
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0364
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0363
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0358
6031 Cytochrome P450 3A43 CYP3A43 0.0356
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0344
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0342
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0341
731 HIV-1 protease HIV-1 protease 0.0339
6020 Aldehyde oxidase AOX1 0.0338
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0333
6182 Cytochrome P450 2J2 CYP2J2 0.0331
2129 Sucrase-isomaltase, intestinal SI 0.0331
6432 Transporter snf 0.0322
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0311
6151 Monocarboxylate transporter 10 SLC16A10 0.0299
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0297
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0296
260 Cytochrome P450 51 ERG11 0.0295
761 Cytochrome P450 51 ERG11 0.0295
3163 Cytochrome P450 51 cyp51 0.0295
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0273
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0266
6138 Multidrug resistance protein 3 ABCB4 0.0262
6143 Solute carrier family 22 member 7 SLC22A7 0.0257
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0256
1636 Trace amine-associated receptor 1 TAAR1 0.0243
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0243
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0241
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0239
817 DNA topoisomerase 2-alpha TOP2A 0.0237
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0236
136 Estrogen receptor ESR1 0.0232
614 Progesterone receptor PGR 0.0226
6142 Solute carrier family 22 member 8 SLC22A8 0.0225
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0223
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0217
3810 Catechol O-methyltransferase COMT 0.0216
290 Prostaglandin G/H synthase 2 PTGS2 0.0216
723 Cytosolic phospholipase A2 PLA2G4A 0.0211
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0209
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0209
380 Cytochrome P450 17A1 CYP17A1 0.0203
3426 Glutamine synthetase glnA 0.0202
3987 Glutamine synthetase GLUL 0.0202
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.02
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0199
2164 Multidrug resistance-associated protein 4 ABCC4 0.0199
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0197
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0196
6148 Multidrug resistance-associated protein 7 ABCC10 0.0194
4120 NADPH--cytochrome P450 reductase POR 0.0193
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0192
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0192
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0191
1618 High affinity nerve growth factor receptor NTRK1 0.0191
1341 Histamine H3 receptor HRH3 0.0189
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0182
153 Dopamine beta-hydroxylase DBH 0.0181
737 Mineralocorticoid receptor NR3C2 0.0179
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0179
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0179
468 Cytochrome P450 4A11 CYP4A11 0.0178
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0174
233 Potassium channel subfamily K member 2 KCNK2 0.017
844 Epidermal growth factor receptor EGFR 0.0169
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0168
516 Neurotensin receptor type 2 NTSR2 0.0168
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0168
232 Corticosteroid-binding globulin SERPINA6 0.0166
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0164
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0163
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0156
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0153
923 Glutamate receptor 3 GRIA3 0.0149
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0149
756 Sex hormone-binding globulin SHBG 0.0148
146 Androgen receptor AR 0.0148
504 Mast/stem cell growth factor receptor KIT 0.0148
362 Melatonin receptor type 1B MTNR1B 0.0147
571 Melatonin receptor type 1A MTNR1A 0.0147
1360 Sphingomyelin phosphodiesterase SMPD1 0.0147
4604 Liver carboxylesterase 1 CES1 0.0145
161 Tubulin beta chain TUBB 0.0139
312 Tubulin beta chain TUB2 0.0139
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0138
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0137
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0136
921 Glutamate receptor 2 GRIA2 0.0136
818 50S ribosomal protein L10 rplJ 0.0135
26 Vascular endothelial growth factor receptor 3 FLT4 0.013
122 P2Y purinoceptor 12 P2RY12 0.013
811 Translocator protein TSPO 0.0128
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0128
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0127
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0127
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
427 Substance-P receptor TACR1 0.0126
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0124
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0124
32 Vascular endothelial growth factor receptor 1 FLT1 0.0124
952 Dipeptidyl peptidase 4 DPP4 0.0124
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0123
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0123
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0123
407 Vascular endothelial growth factor receptor 2 KDR 0.0123
6137 Multidrug resistance-associated protein 6 ABCC6 0.0123
228 Beta platelet-derived growth factor receptor PDGFRB 0.0121
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0119
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0118
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0117
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0117
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0117
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0117
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
777 Tumor necrosis factor TNF 0.0113
3947 Xanthine dehydrogenase/oxidase XDH 0.0113
6141 Sodium/bile acid cotransporter SLC10A1 0.0111
29 Tubulin beta-1 chain TUBB1 0.0111
477 DNA topoisomerase 4 subunit A parC 0.0109
886 DNA topoisomerase 4 subunit A parC 0.0109
6226 DNA topoisomerase 4 subunit A parC 0.0109
404 DNA gyrase subunit A gyrA 0.0108
6224 DNA gyrase subunit A gyrA 0.0108
6136 Multidrug resistance-associated protein 5 ABCC5 0.0107
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0106
6220 Aryl hydrocarbon receptor AHR 0.0104
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0104
1010 Cytochrome P450 51A1 CYP51A1 0.0103
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0102
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0102
1024 Solute carrier family 22 member 11 SLC22A11 0.0101
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.01
768 FK506-binding protein 1A FKBP1A 0.01
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0099
1275 Estrogen sulfotransferase SULT1E1 0.0098
2539 Tubulin alpha-1 chain TUBA4A 0.0098
4237 50S ribosomal protein L22 rplV 0.0095
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0092
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0091
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0091
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.009
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0089
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0089
869 Estrogen receptor beta ESR2 0.0089
70 Type-1 angiotensin II receptor AGTR1 0.0088
6859 Protein S100-A4 S100A4 0.0088
1192 Sulfotransferase 1A1 SULT1A1 0.0086
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0086
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0085
904 Glutathione S-transferase P GSTP1 0.0084
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0084
4238 50S ribosomal protein L4 rplD 0.0083
5578 50S ribosomal protein L4 rplD 0.0083
6173 50S ribosomal protein L4 rplD 0.0083
6219 50S ribosomal protein L4 rplD 0.0083
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0083
2112 Toll-like receptor 9 TLR9 0.008
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.008
165 FL cytokine receptor FLT3 0.008
1353 DNA topoisomerase 1 TOP1 0.008
3552 DNA topoisomerase 1 topA 0.008
1852 Microtubule-associated protein 2 MAP2 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
373 Transthyretin TTR 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0075
4203 Histamine N-methyltransferase HNMT 0.0075
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0074
208 DNA-directed RNA polymerase beta' chain rpoC 0.0074
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0074
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
738 Monocarboxylate transporter 1 SLC16A1 0.0072
705 Glutamate receptor 1 GRIA1 0.0072
5300 Antigen peptide transporter 1 TAP1 0.0072
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0072
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0071
6102 Arylamine N-acetyltransferase 2 NAT2 0.0071
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0071
319 Opioid receptor, sigma 1 OPRS1 0.0069
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0068
814 Ryanodine receptor 1 RYR1 0.0067
469 Annexin A1 ANXA1 0.0067
6014 Cytochrome P450 2A13 CYP2A13 0.0066
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0066
239 Coagulation factor X F10 0.0066
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0064
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
2449 Tubulin alpha-3 chain TUBA1A 0.0062
1178 Adenosine A2a receptor ADORA2A 0.0062
592 Carbonic anhydrase 4 CA4 0.0062
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0061
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0061
295 Carbonic anhydrase 1 CA1 0.0061
6097 Protein S100-A2 S100A2 0.006
273 Apoptosis regulator Bcl-2 BCL2 0.006
1810 Protein S100-A1 S100A1 0.006
1050 Bile salt sulfotransferase SULT2A1 0.006
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
5923 Microtubule-associated protein tau MAPT 0.0059
5924 Microtubule-associated protein 4 MAP4 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
1483 Membrane copper amine oxidase AOC3 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
183 Vascular endothelial growth factor A VEGFA 0.0056
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0056
6506 Stathmin-4 STMN4 0.0055
1196 Complement decay-accelerating factor CD55 0.0055
4773 Deoxycytidine kinase DCK 0.0055
891 Dihydropteroate synthase folP 0.0054
5359 Dihydropteroate synthase folP 0.0054
7175 Dihydropteroate synthase sulI 0.0054
365 Dihydrofolate reductase DHFR 0.0053
2381 Dihydrofolate reductase DFR1 0.0053
2833 Dihydrofolate reductase Not Available 0.0053
2931 Dihydrofolate reductase folA 0.0053
3544 Dihydrofolate reductase folA 0.0053
3682 Dihydrofolate reductase folA 0.0053
6642 Dihydrofolate reductase folA 0.0053
6756 Dihydrofolate reductase dfrA 0.0053
823 Fibroblast growth factor receptor 2 FGFR2 0.0053
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0053
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0053
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0052
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0052
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0052
49 Endothelin B receptor EDNRB 0.0052
1048 Protein S100-A13 S100A13 0.0052
2226 Protein S100-A12 S100A12 0.0052
694 Matrix protein 2 M 0.0051
4311 tRNA TRDMT1 0.0051
4325 tRNA trmD 0.0051
4328 tRNA trmD 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
3932 Glutathione S-transferase A2 GSTA2 0.005
1630 Integrin beta-2 ITGB2 0.005
976 Platelet glycoprotein IX GP9 0.0049
4122 Histone deacetylase 2 HDAC2 0.0049
84 Nuclear receptor 0B1 NR0B1 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0049
2132 Protein S100-B S100B 0.0049
173 Toll-like receptor 7 TLR7 0.0049
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0049
1757 Myeloperoxidase MPO 0.0049
284 DNA-directed RNA polymerase beta chain rpoB 0.0049
5773 DNA-directed RNA polymerase beta chain rpoB 0.0049
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0048
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0048
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0048
2808 Chloramphenicol acetyltransferase 3 cat3 0.0047
856 Vitamin D3 receptor VDR 0.0047
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
357 Carbonic anhydrase 2 CA2 0.0046
3086 Plasmepsin-2 Not Available 0.0046
6174 50S ribosomal protein L32 rpmF 0.0045
54 Prothrombin F2 0.0045
1629 Transcription factor AP-1 JUN 0.0045
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0045
16 Adenosine A1 receptor ADORA1 0.0044
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0044
3601 Dihydropteroate synthase 1 folP1 0.0043
3807 Dihydropteroate synthase 1 folP1 0.0043
3808 Dihydropteroate synthase 2 folP2 0.0043
2417 Chloramphenicol acetyltransferase cat 0.0043
3278 Chloramphenicol acetyltransferase cat 0.0043
2810 Dr hemagglutinin structural subunit draA 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
6085 Fatty acid-binding protein, intestinal FABP2 0.0042
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0042
4103 Proteasome subunit beta type 2 PSMB2 0.0042
4102 Proteasome subunit beta type 5 PSMB5 0.0042
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0042
4101 Proteasome subunit beta type 1 PSMB1 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
3913 Glutamic acid decarboxylase GAD65 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6044 Serum paraoxonase/lactonase 3 PON3 0.004
3856 Fibroblast growth factor receptor 3 FGFR3 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0039
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0038
6824 Tyrosine-protein kinase Lyn LYN 0.0038
6043 Putative G-protein coupled receptor 44 GPR44 0.0038
85 Growth hormone receptor GHR 0.0038
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0037
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0037
572 Integrin alpha-L ITGAL 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0036
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0036
1864 RET proto-oncogene RET 0.0036
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0036
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0036
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
1374 Natriuretic peptides B NPPB 0.0036
1827 Gap junction alpha-1 protein GJA1 0.0036
1908 Vascular cell adhesion protein 1 VCAM1 0.0036
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0035
5787 Angiopoietin-1 receptor TEK 0.0035
6048 Troponin C, skeletal muscle TNNC2 0.0035
780 Retinoic acid receptor RXR-gamma RXRG 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0035
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0034
6126 Carbonic anhydrase 7 CA7 0.0034
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0033
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0033
5934 Cytochrome P450 26A1 CYP26A1 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0032
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0032
33 Cystine/glutamate transporter SLC7A11 0.0032
7 Nitric oxide synthase, inducible NOS2 0.0032
3809 Estrogen-related receptor gamma ESRRG 0.0032
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0032
88 Retinoic acid receptor RXR-beta RXRB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
581 Cytochrome P450 2R1 CYP2R1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
275 Arachidonate 5-lipoxygenase ALOX5 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
4192 DNA topoisomerase 2-beta TOP2B 0.003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.003
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.003
106 Cannabinoid receptor 2 CNR2 0.003
518 Peroxidase/catalase T katG 0.003
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0029
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
936 Ephrin type-A receptor 2 EPHA2 0.0028
24 Thymidylate synthase TMP1 0.0027
359 Thymidylate synthase TYMS 0.0027
2626 Thymidylate synthase thyA 0.0027
2729 Thymidylate synthase thyA 0.0027
5352 Thymidylate synthase THYA 0.0027
563 Thyroid peroxidase TPO 0.0027
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
267 Plasminogen activator inhibitor 1 SERPINE1 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0026
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
2216 Fibroblast growth factor receptor 4 FGFR4 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
634 Squalene monooxygenase SQLE 0.0026
7196 Squalene monooxygenase ERG1 0.0026
482 Glycine receptor subunit alpha-1 GLRA1 0.0026
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0025
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0025
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0025
605 Fumarate reductase flavoprotein subunit frdA 0.0024
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0024
3673 Fumarate reductase flavoprotein subunit fccA 0.0024
4912 Fumarate reductase flavoprotein subunit ifcA 0.0024
6549 Fumarate reductase flavoprotein subunit frdA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0024
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0024
6221 Steroid hormone receptor ERR1 ESRRA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
719 Retinoic acid receptor responder protein 1 RARRES1 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
770 Retinoic acid-induced protein 3 GPRC5A 0.0024
6149 Solute carrier family 22 member 10 SLC22A10 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
1262 Corticotropin-lipotropin POMC 0.0022
162 Retinoic acid receptor gamma-1 RARG 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
298 Renin REN 0.0021
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0021
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0021
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
6146 High affinity copper uptake protein 1 SLC31A1 0.0021
569 Retinal dehydrogenase 2 ALDH1A2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.002
1063 Signal transducer and activator of transcription 5B STAT5B 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
1992 Vitamin D-binding protein GC 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
751 Potassium channel subfamily K member 6 KCNK6 0.002
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.002
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.002
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.002
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.002
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.002
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0019
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
558 Solute carrier family 12 member 1 SLC12A1 0.0018
4217 Telomerase reverse transcriptase TERT 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
172 Potassium channel subfamily K member 1 KCNK1 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0017
537 ATP synthase delta chain, mitochondrial ATP5D 0.0017
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0017
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0017
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0017
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
908 Glutathione S-transferase theta-1 GSTT1 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0016
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0016
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0015
3233 Bile acid receptor NR1H4 0.0015
3937 Fatty-acid amide hydrolase FAAH 0.0015
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0015
6755 Poliovirus receptor PVR 0.0015
3957 Adenosine deaminase ADA 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0015
1039 Histone deacetylase 9 HDAC9 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
291 Nitric-oxide synthase, endothelial NOS3 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
1541 Metalloproteinase mmp20 0.0014
2320 Thymidine kinase, cytosolic TK1 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2981 Phospholipase A2, membrane associated PLA2G2A 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
444 Alcohol dehydrogenase 1B ADH1B 0.0013
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0013
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
6218 Pannexin-1 PANX1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
489 Monocarboxylate transporter 2 SLC16A7 0.0012
2021 Thrombomodulin THBD 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0011
251 Alcohol dehydrogenase 1A ADH1A 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
6459 Glycodelin PAEP 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
517 Alcohol dehydrogenase 1C ADH1C 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
820 Glycine receptor subunit alpha-2 GLRA2 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
2207 Rhodopsin RHO 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
3830 Calreticulin CALR 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
1648 Elastin ELN 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
268 Adenosine A2b receptor ADORA2B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
6034 Hydroxyindole O-methyltransferase ASMT 0.0009
6035 Nuclear receptor ROR-beta RORB 0.0009
6036 Eosinophil peroxidase EPX 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
229 Retinoic acid receptor beta RARB 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2298 Cytochrome P450-cam camC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3221 Cytochrome c4 cc4 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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