DT-Web

DB00757 - Dolasetron


Identification
Name Dolasetron
Accession Number DB00757 (APRD00518)
Type small molecule
Description Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug has not shown to have activity at other known serotonin receptors, and has low affinity for dopamine receptors.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 324.3737
Groups approved
Monoisotopic Weight 324.147392516
Pharmacology
Indication For the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including initial and repeat courses of chemotherapy. Also used for the prevention of postoperative nausea and vomiting. This drug can be used intravenously for the treatment of postoperative nausea and vomiting.
Mechanism of action Dolasetron is a selective serotonin 5-HT3 receptor antagonist. In vivo, the drug is rapidly converted into its major active metabolite, hydrodolasetron, which seems to be largely responsible for the drug's pharmacological activity. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.
Absorption Orally-administered dolasetron is well absorbed
Protein binding 69-77%
Biotransformation Hepatic
Route of elimination Hydrodolasetron is eliminated by multiple routes, including renal excretion and, after metabolism, mainly glucuronidation, and hydroxylation.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Voriconazole Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Take without regard to meals.

Targets


5-hydroxytryptamine 3 receptor
Name 5-hydroxytryptamine 3 receptor
Gene Name HTR3A
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Conroy T, Cappelaere P, Fabbro M, Fauser AA, Splinter TA, Spielmann M, Schneider M, Chevallier B, Goupil A, Chauvergne J, et al.: Acute antiemetic efficacy and safety of dolasetron mesylate, a 5-HT3 antagonist, in cancer patients treated with cisplatin. European Dolasetron Study Group. Am J Clin Oncol. 1994 Apr;17(2):97-102. - Pubmed
  • Reith MK, Sproles GD, Cheng LK: Human metabolism of dolasetron mesylate, a 5-HT3 receptor antagonist. Drug Metab Dispos. 1995 Aug;23(8):806-12. - Pubmed
  • Eisenberg P, Figueroa-Vadillo J, Zamora R, Charu V, Hajdenberg J, Cartmell A, Macciocchi A, Grunberg S: Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist: results of a phase III, single-dose trial versus dolasetron. Cancer. 2003 Dec 1;98(11):2473-82. - Pubmed
  • Monaca-Charley C, Stojkovic T, Duhamel A, De Seze J, Ferriby D, Vermersch P: Double-blind crossover study with dolasetron mesilate, a 5-HT3 receptor antagonist in cerebellar syndrome secondary to multiple sclerosis. J Neurol. 2003 Oct;250(10):1190-4. - Pubmed
  • Boeijinga PH, Galvan M, Baron BM, Dudley MW, Siegel BW, Slone AL: Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma x glioma cells. Eur J Pharmacol. 1992 Aug 14;219(1):9-13. - Pubmed
  • Balfour JA, Goa KL: Dolasetron. A review of its pharmacology and therapeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery. Drugs. 1997 Aug;54(2):273-98. - Pubmed
  • Hui YF, Ignoffo RJ: Dolasetron. A new 5-hydroxytryptamine3 receptor antagonist. Cancer Pract. 1997 Sep-Oct;5(5):324-8. - Pubmed
  • Gregory RE, Ettinger DS: 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy. Drugs. 1998 Feb;55(2):173-89. - Pubmed
  • Gan TJ: Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same? CNS Drugs. 2005;19(3):225-38. - Pubmed
DTHybrid score 0.1969

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • -
  • Sanwald P, David M, Dow J: Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of dolasetron. Comparison with other indole-containing 5-HT3 antagonists. Drug Metab Dispos. 1996 May;24(5):602-9. - Pubmed
DTHybrid score 0.4279
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Janicki PK: Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Med Sci Monit. 2005 Oct;11(10):RA322-8. Epub 2005 Sep 26. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Sanwald P, David M, Dow J: Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of dolasetron. Comparison with other indole-containing 5-HT3 antagonists. Drug Metab Dispos. 1996 May;24(5):602-9. - Pubmed
DTHybrid score 0.3628
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.308

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.1706
4200 Cytochrome P450 1A2 CYP1A2 0.1565
4924 Cytochrome P450 2C8 CYP2C8 0.1342
4118 Cytochrome P450 3A5 CYP3A5 0.1219
1588 Multidrug resistance protein 1 ABCB1 0.1169
6030 Cytochrome P450 2B6 CYP2B6 0.0918
6013 Cytochrome P450 2E1 CYP2E1 0.0872
6107 Cytochrome P450 3A7 CYP3A7 0.0867
5718 Cytochrome P450 2A6 CYP2A6 0.0593
492 Histamine H1 receptor HRH1 0.059
6024 Cytochrome P450 1A1 CYP1A1 0.0582
20 Prostaglandin G/H synthase 1 PTGS1 0.0504
502 5-hydroxytryptamine 2A receptor HTR2A 0.0462
587 Serum albumin ALB 0.0458
824 Sodium-dependent serotonin transporter SLC6A4 0.0435
713 Sodium-dependent dopamine transporter SLC6A3 0.0413
6145 Solute carrier family 22 member 1 SLC22A1 0.0407
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0396
831 D(2) dopamine receptor DRD2 0.0377
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0372
556 Alpha-1A adrenergic receptor ADRA1A 0.0364
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0346
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0342
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0339
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0338
320 5-hydroxytryptamine 1A receptor HTR1A 0.0338
590 5-hydroxytryptamine 2C receptor HTR2C 0.0334
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0333
318 Alpha-2A adrenergic receptor ADRA2A 0.0332
6144 Solute carrier family 22 member 2 SLC22A2 0.0325
847 Mu-type opioid receptor OPRM1 0.0321
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0294
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0293
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0282
696 Kappa-type opioid receptor OPRK1 0.0271
290 Prostaglandin G/H synthase 2 PTGS2 0.0269
23 D(1A) dopamine receptor DRD1 0.0263
632 Alpha-1B adrenergic receptor ADRA1B 0.0262
3923 Cholinesterase BCHE 0.0258
766 Beta-2 adrenergic receptor ADRB2 0.0258
6106 Cytochrome P450 2C18 CYP2C18 0.0253
885 5-hydroxytryptamine 1B receptor HTR1B 0.0249
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0247
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0242
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0239
467 Delta-type opioid receptor OPRD1 0.0238
274 Muscarinic acetylcholine receptor M5 CHRM5 0.023
862 Multidrug resistance-associated protein 1 ABCC1 0.0228
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0225
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0224
1729 Solute carrier family 22 member 6 SLC22A6 0.0221
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0217
638 D(3) dopamine receptor DRD3 0.0217
193 Beta-1 adrenergic receptor ADRB1 0.0214
3811 Cytochrome P450 19A1 CYP19A1 0.0212
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0212
629 Alpha-2B adrenergic receptor ADRA2B 0.0202
474 Acetylcholinesterase ACHE 0.0197
432 D(4) dopamine receptor DRD4 0.0193
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0193
731 HIV-1 protease HIV-1 protease 0.0191
94 5-hydroxytryptamine 4 receptor HTR4 0.0189
378 Alpha-2C adrenergic receptor ADRA2C 0.0187
1898 Cytochrome P450 1B1 CYP1B1 0.0185
871 Glucocorticoid receptor NR3C1 0.0184
725 5-hydroxytryptamine 1D receptor HTR1D 0.018
136 Estrogen receptor ESR1 0.0179
118 Organic cation/carnitine transporter 2 SLC22A5 0.0174
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0171
716 5-hydroxytryptamine 7 receptor HTR7 0.0169
528 5-hydroxytryptamine 1E receptor HTR1E 0.0161
1256 5-hydroxytryptamine 6 receptor HTR6 0.016
163 D(1B) dopamine receptor DRD5 0.0153
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.015
776 Bile salt export pump ABCB11 0.0141
891 Dihydropteroate synthase folP 0.014
5359 Dihydropteroate synthase folP 0.014
7175 Dihydropteroate synthase sulI 0.014
3941 Amine oxidase [flavin-containing] A MAOA 0.0131
789 Alpha-1D adrenergic receptor ADRA1D 0.0127
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0126
2164 Multidrug resistance-associated protein 4 ABCC4 0.0124
6142 Solute carrier family 22 member 8 SLC22A8 0.0124
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0121
122 P2Y purinoceptor 12 P2RY12 0.0117
260 Cytochrome P450 51 ERG11 0.0116
761 Cytochrome P450 51 ERG11 0.0116
3163 Cytochrome P450 51 cyp51 0.0116
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0116
465 Calmodulin CALM1 0.0115
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0114
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0107
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0106
3939 Amine oxidase [flavin-containing] B MAOB 0.0105
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0104
6031 Cytochrome P450 3A43 CYP3A43 0.0103
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0103
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0103
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0103
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0103
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0101
833 Organic cation/carnitine transporter 1 SLC22A4 0.0101
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0099
6143 Solute carrier family 22 member 7 SLC22A7 0.0098
70 Type-1 angiotensin II receptor AGTR1 0.0097
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0096
436 5-hydroxytryptamine 2B receptor HTR2B 0.0096
817 DNA topoisomerase 2-alpha TOP2A 0.0096
6147 Solute carrier family 22 member 3 SLC22A3 0.0095
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0093
232 Corticosteroid-binding globulin SERPINA6 0.0093
6182 Cytochrome P450 2J2 CYP2J2 0.0092
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.009
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0089
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0088
614 Progesterone receptor PGR 0.0087
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0085
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0084
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0081
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.008
468 Cytochrome P450 4A11 CYP4A11 0.008
146 Androgen receptor AR 0.008
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0079
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0078
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0078
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0078
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0078
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0076
1024 Solute carrier family 22 member 11 SLC22A11 0.0074
592 Carbonic anhydrase 4 CA4 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
4116 Dihydropteroate synthetase Not Available 0.0072
295 Carbonic anhydrase 1 CA1 0.0072
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0069
49 Endothelin B receptor EDNRB 0.0069
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0067
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0067
811 Translocator protein TSPO 0.0066
161 Tubulin beta chain TUBB 0.0066
312 Tubulin beta chain TUB2 0.0066
578 Endothelin-1 receptor EDNRA 0.0065
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0064
380 Cytochrome P450 17A1 CYP17A1 0.0063
952 Dipeptidyl peptidase 4 DPP4 0.0063
504 Mast/stem cell growth factor receptor KIT 0.0063
365 Dihydrofolate reductase DHFR 0.0063
2381 Dihydrofolate reductase DFR1 0.0063
2833 Dihydrofolate reductase Not Available 0.0063
2931 Dihydrofolate reductase folA 0.0063
3544 Dihydrofolate reductase folA 0.0063
3682 Dihydrofolate reductase folA 0.0063
6642 Dihydrofolate reductase folA 0.0063
6756 Dihydrofolate reductase dfrA 0.0063
133 Dihydropterate synthase sulI 0.0063
4604 Liver carboxylesterase 1 CES1 0.0062
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.006
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.006
131 Synaptic vesicular amine transporter SLC18A2 0.0059
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0059
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0059
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0059
124 Histamine H2 receptor HRH2 0.0059
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0058
818 50S ribosomal protein L10 rplJ 0.0058
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0058
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0058
6220 Aryl hydrocarbon receptor AHR 0.0058
6102 Arylamine N-acetyltransferase 2 NAT2 0.0057
407 Vascular endothelial growth factor receptor 2 KDR 0.0057
1656 CYP2B protein CYP2B 0.0056
6137 Multidrug resistance-associated protein 6 ABCC6 0.0055
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0055
6506 Stathmin-4 STMN4 0.0055
357 Carbonic anhydrase 2 CA2 0.0055
844 Epidermal growth factor receptor EGFR 0.0054
3810 Catechol O-methyltransferase COMT 0.0054
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0054
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0054
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0054
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0053
6148 Multidrug resistance-associated protein 7 ABCC10 0.0053
164 Histamine H4 receptor HRH4 0.0053
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0053
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0053
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0053
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0053
29 Tubulin beta-1 chain TUBB1 0.0052
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0051
2112 Toll-like receptor 9 TLR9 0.0051
777 Tumor necrosis factor TNF 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
6136 Multidrug resistance-associated protein 5 ABCC5 0.005
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0049
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0049
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0049
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0049
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0049
173 Toll-like receptor 7 TLR7 0.0049
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0048
4120 NADPH--cytochrome P450 reductase POR 0.0048
3947 Xanthine dehydrogenase/oxidase XDH 0.0047
6014 Cytochrome P450 2A13 CYP2A13 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
565 Extracellular calcium-sensing receptor CASR 0.0046
856 Vitamin D3 receptor VDR 0.0046
6126 Carbonic anhydrase 7 CA7 0.0046
68 Cannabinoid receptor 1 CNR1 0.0046
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0046
527 Prostacyclin receptor PTGIR 0.0045
814 Ryanodine receptor 1 RYR1 0.0045
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0045
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0045
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0044
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0044
482 Glycine receptor subunit alpha-1 GLRA1 0.0044
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0044
130 Prostacyclin synthase PTGIS 0.0044
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0043
756 Sex hormone-binding globulin SHBG 0.0043
869 Estrogen receptor beta ESR2 0.0043
1275 Estrogen sulfotransferase SULT1E1 0.0043
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0043
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0043
1629 Transcription factor AP-1 JUN 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
1757 Myeloperoxidase MPO 0.0041
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0041
1010 Cytochrome P450 51A1 CYP51A1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
427 Substance-P receptor TACR1 0.004
275 Arachidonate 5-lipoxygenase ALOX5 0.004
373 Transthyretin TTR 0.004
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.004
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.004
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.004
1541 Metalloproteinase mmp20 0.0039
6141 Sodium/bile acid cotransporter SLC10A1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
1178 Adenosine A2a receptor ADORA2A 0.0039
228 Beta platelet-derived growth factor receptor PDGFRB 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
738 Monocarboxylate transporter 1 SLC16A1 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0038
183 Vascular endothelial growth factor A VEGFA 0.0038
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0038
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0037
208 DNA-directed RNA polymerase beta' chain rpoC 0.0037
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0037
54 Prothrombin F2 0.0037
1050 Bile salt sulfotransferase SULT2A1 0.0036
705 Glutamate receptor 1 GRIA1 0.0036
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0036
737 Mineralocorticoid receptor NR3C2 0.0036
26 Vascular endothelial growth factor receptor 3 FLT4 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0035
939 50S ribosomal protein L3 rplC 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
32 Vascular endothelial growth factor receptor 1 FLT1 0.0034
24 Thymidylate synthase TMP1 0.0034
359 Thymidylate synthase TYMS 0.0034
2626 Thymidylate synthase thyA 0.0034
2729 Thymidylate synthase thyA 0.0034
5352 Thymidylate synthase THYA 0.0034
6020 Aldehyde oxidase AOX1 0.0033
780 Retinoic acid receptor RXR-gamma RXRG 0.0033
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
153 Dopamine beta-hydroxylase DBH 0.0033
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0033
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0033
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0033
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0033
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
284 DNA-directed RNA polymerase beta chain rpoB 0.0032
5773 DNA-directed RNA polymerase beta chain rpoB 0.0032
6085 Fatty acid-binding protein, intestinal FABP2 0.0032
4122 Histone deacetylase 2 HDAC2 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0031
16 Adenosine A1 receptor ADORA1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
88 Retinoic acid receptor RXR-beta RXRB 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
581 Cytochrome P450 2R1 CYP2R1 0.003
174 Sigma 1-type opioid receptor SIGMAR1 0.003
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0029
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
518 Peroxidase/catalase T katG 0.0028
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
3932 Glutathione S-transferase A2 GSTA2 0.0028
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0027
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
2449 Tubulin alpha-3 chain TUBA1A 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
537 ATP synthase delta chain, mitochondrial ATP5D 0.0027
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0027
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0026
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0026
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0025
921 Glutamate receptor 2 GRIA2 0.0025
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0025
6138 Multidrug resistance protein 3 ABCB4 0.0025
563 Thyroid peroxidase TPO 0.0025
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
1618 High affinity nerve growth factor receptor NTRK1 0.0025
1648 Elastin ELN 0.0024
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0024
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0024
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1517 Beta-3 adrenergic receptor ADRB3 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4773 Deoxycytidine kinase DCK 0.0024
634 Squalene monooxygenase SQLE 0.0024
7196 Squalene monooxygenase ERG1 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0023
1341 Histamine H3 receptor HRH3 0.0023
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
1192 Sulfotransferase 1A1 SULT1A1 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
823 Fibroblast growth factor receptor 2 FGFR2 0.0022
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0022
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0022
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0022
3404 Exotoxin A eta 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0021
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0021
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0021
165 FL cytokine receptor FLT3 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
1852 Microtubule-associated protein 2 MAP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.002
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.002
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.002
6432 Transporter snf 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
215 Sodium channel protein type 11 subunit alpha SCN11A 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
6146 High affinity copper uptake protein 1 SLC31A1 0.002
904 Glutathione S-transferase P GSTP1 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
5787 Angiopoietin-1 receptor TEK 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0019
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
1992 Vitamin D-binding protein GC 0.0019
2981 Phospholipase A2, membrane associated PLA2G2A 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
319 Opioid receptor, sigma 1 OPRS1 0.0018
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0018
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0018
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
84 Nuclear receptor 0B1 NR0B1 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
239 Coagulation factor X F10 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0017
976 Platelet glycoprotein IX GP9 0.0017
4103 Proteasome subunit beta type 2 PSMB2 0.0017
4102 Proteasome subunit beta type 5 PSMB5 0.0017
4101 Proteasome subunit beta type 1 PSMB1 0.0017
1630 Integrin beta-2 ITGB2 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
1374 Natriuretic peptides B NPPB 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
106 Cannabinoid receptor 2 CNR2 0.0017
4311 tRNA TRDMT1 0.0017
4325 tRNA trmD 0.0017
4328 tRNA trmD 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
6174 50S ribosomal protein L32 rpmF 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0017
1196 Complement decay-accelerating factor CD55 0.0017
3809 Estrogen-related receptor gamma ESRRG 0.0017
7 Nitric oxide synthase, inducible NOS2 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
511 5-hydroxytryptamine 1F receptor HTR1F 0.0016
6149 Solute carrier family 22 member 10 SLC22A10 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
3233 Bile acid receptor NR1H4 0.0015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
558 Solute carrier family 12 member 1 SLC12A1 0.0015
6048 Troponin C, skeletal muscle TNNC2 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0015
273 Apoptosis regulator Bcl-2 BCL2 0.0015
3937 Fatty-acid amide hydrolase FAAH 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
2808 Chloramphenicol acetyltransferase 3 cat3 0.0014
6824 Tyrosine-protein kinase Lyn LYN 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0014
6044 Serum paraoxonase/lactonase 3 PON3 0.0014
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
469 Annexin A1 ANXA1 0.0014
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0014
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
572 Integrin alpha-L ITGAL 0.0013
2417 Chloramphenicol acetyltransferase cat 0.0013
3278 Chloramphenicol acetyltransferase cat 0.0013
3808 Dihydropteroate synthase 2 folP2 0.0013
3601 Dihydropteroate synthase 1 folP1 0.0013
3807 Dihydropteroate synthase 1 folP1 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
2810 Dr hemagglutinin structural subunit draA 0.0013
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0013
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0013
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0013
1864 RET proto-oncogene RET 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
5924 Microtubule-associated protein 4 MAP4 0.0012
5923 Microtubule-associated protein tau MAPT 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0012
1295 Fatty acid synthase FASN 0.0012
1268 Neuropeptide S receptor NPSR1 0.0012
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0012
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0012
5934 Cytochrome P450 26A1 CYP26A1 0.0011
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0011
751 Potassium channel subfamily K member 6 KCNK6 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
6073 Potassium channel subfamily K member 9 KCNK9 0.0011
6072 Potassium channel subfamily K member 3 KCNK3 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
605 Fumarate reductase flavoprotein subunit frdA 0.0011
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0011
3673 Fumarate reductase flavoprotein subunit fccA 0.0011
4912 Fumarate reductase flavoprotein subunit ifcA 0.0011
6549 Fumarate reductase flavoprotein subunit frdA 0.0011
4217 Telomerase reverse transcriptase TERT 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.001
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
172 Potassium channel subfamily K member 1 KCNK1 0.001
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.001
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.001
291 Nitric-oxide synthase, endothelial NOS3 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2450 Tyrosine-protein kinase ITK/TSK ITK 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
936 Ephrin type-A receptor 2 EPHA2 0.001
3957 Adenosine deaminase ADA 0.001
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
820 Glycine receptor subunit alpha-2 GLRA2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
33 Cystine/glutamate transporter SLC7A11 0.0009
444 Alcohol dehydrogenase 1B ADH1B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
2320 Thymidine kinase, cytosolic TK1 0.0008
2207 Rhodopsin RHO 0.0008
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
267 Plasminogen activator inhibitor 1 SERPINE1 0.0008
1867 Major prion protein PRNP 0.0008
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0008
4948 Cytochrome c-553 Not Available 0.0008
4923 Cytochrome c3 DvMF_2499 0.0008
4945 Cytochrome c3 Not Available 0.0008
4949 Cytochrome c3 DVU_3171 0.0008
4968 Cytochrome c3 cytc3 0.0008
4997 Cytochrome c3 SO_2727 0.0008
5219 Cytochrome c3 cyd 0.0008
4902 Nine-heme cytochrome c Ddes_2038 0.0008
3189 High-molecular-weight cytochrome c hmcA 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0008
1025 Aquaporin-1 AQP1 0.0008
517 Alcohol dehydrogenase 1C ADH1C 0.0008
3830 Calreticulin CALR 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
2298 Cytochrome P450-cam camC 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0007
6221 Steroid hormone receptor ERR1 ESRRA 0.0007
6218 Pannexin-1 PANX1 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
1039 Histone deacetylase 9 HDAC9 0.0007
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
125 DNA polymerase beta POLB 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
1360 Sphingomyelin phosphodiesterase SMPD1 0.0006
908 Glutathione S-transferase theta-1 GSTT1 0.0006
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0006
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
3221 Cytochrome c4 cc4 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
162 Retinoic acid receptor gamma-1 RARG 0.0006
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0006
4192 DNA topoisomerase 2-beta TOP2B 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
2021 Thrombomodulin THBD 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1507 Cytochrome c CYCS 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
489 Monocarboxylate transporter 2 SLC16A7 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3917 Methylenetetrahydrofolate reductase MTHFR 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4943 Cytochrome c6 petJ 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
5000 HemO hemO 0.0003
4910 Cytoglobin CYGB 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4909 CooA protein cooA 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4942 Diheme cytochrome c napB napB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
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