DT-Web

DB07690 - (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID


Identification
Name (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID
Accession Number DB07690
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 392.572
Groups experimental
Monoisotopic Weight 392.292659768
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Steroid Delta-isomerase
Name Steroid Delta-isomerase
Gene Name ksi
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.3362
PpcA
Name PpcA
Gene Name ppcA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9985
Elongation factor Tu GTP-binding domain-containing protein 1
Name Elongation factor Tu GTP-binding domain-containing protein 1
Gene Name EFTUD1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1491
Choloylglycine hydrolase
Name Choloylglycine hydrolase
Gene Name cbh
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2602
Lactaldehyde dehydrogenase
Name Lactaldehyde dehydrogenase
Gene Name aldA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1515
Acriflavine resistance protein B
Name Acriflavine resistance protein B
Gene Name acrB
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.4623
Cytochrome c oxidase subunit 1
Name Cytochrome c oxidase subunit 1
Gene Name ctaD
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.0181
Cytochrome c oxidase subunit 2
Name Cytochrome c oxidase subunit 2
Gene Name ctaC
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.0181

Predictions


Id Partner name Gene Name Score
2920 Steroid Delta-isomerase ksi 1.3362
2331 HTH-type transcriptional regulator qacR qacR 0.427
6461 HTH-type transcriptional regulator qacR qacR 0.427
2529 Alpha-ketoglutarate-dependent taurine dioxygenase tauD 0.3538
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.1243
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.1197
2268 Cholesterol oxidase choB 0.088
2822 Cholesterol oxidase choA 0.088
862 Multidrug resistance-associated protein 1 ABCC1 0.0799
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0766
1050 Bile salt sulfotransferase SULT2A1 0.0662
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0589
6107 Cytochrome P450 3A7 CYP3A7 0.0251
4512 Cytochrome P450 3A4 CYP3A4 0.0219
2170 Transforming protein RhoA RHOA 0.0214
3197 GDP-mannose mannosyl hydrolase nudD 0.0214
5630 ADP-ribosylation factor-like protein 5A ARL5A 0.0214
5618 ADP-ribosylation factor 4 ARF4 0.0214
1882 Ras-related C3 botulinum toxin substrate 1 RAC1 0.0214
5624 GTPase rab6 0.0214
5628 Probable GTPase engC rsgA 0.0214
5627 GDP-mannose 4,6-dehydratase gca 0.0214
3366 GTP-binding protein engA der 0.0214
2391 Ferrochelatase hemH 0.0208
6502 Ferrochelatase DKFZp686P18130 0.0208
1591 Ferrochelatase, mitochondrial FECH 0.0208
3396 Elongation factor Tu tufA 0.0187
5621 Elongation factor Tu tuf 0.0187
3170 Elongation factor Tu-B tufB 0.0187
3335 Probable GTP-binding protein engB engB 0.0187
3115 Ras-related protein Rab-9 RAB9A 0.0186
3270 Elongation factor G fusA 0.0186
3354 Ras-related protein Rap-2a RAP2A 0.0186
3261 Signal recognition particle protein ffh 0.0186
5619 GDP-mannose 4,6 dehydratase GMDS 0.0186
3107 Putative GTP pyrophosphokinase relA 0.0186
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0181
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0181
6493 Cytochrome c oxidase subunit 6C COX6C 0.0181
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0181
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0181
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0181
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0181
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0181
6669 Cytochrome c oxidase subunit 2 ctaC 0.0181
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0181
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0181
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0181
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0181
6750 ADP-ribosylation factor 6 ARF6 0.0172
2521 Cell division protein ftsZ ftsZ 0.0172
3301 Cell division protein ftsZ ftsZ 0.0172
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0172
3587 Gastrotropin FABP6 0.0167
6790 Elongation factor 2 EEF2 0.0163
6501 Fatty acid-binding protein, liver FABP1 0.0158
1758 GTPase HRas HRAS 0.0155
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0155
6316 ADP-ribosylation factor 1 ARF1 0.0145
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0145
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0138
2632 Adenylosuccinate synthetase purA 0.0135
3323 Adenylosuccinate synthetase purA 0.0135
3975 Adenylosuccinate synthetase ADSS 0.0135
4598 Adenylosuccinate synthetase Adss 0.0135
6817 Adenylosuccinate synthetase purA 0.0135
6500 Phospholipase A2 PLA2G1B 0.0127
3809 Estrogen-related receptor gamma ESRRG 0.0125
5626 Nucleoside diphosphate kinase B NME2 0.0118
5294 Nucleoside diphosphate kinase A NME1 0.0115
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0114
517 Alcohol dehydrogenase 1C ADH1C 0.0107
6141 Sodium/bile acid cotransporter SLC10A1 0.0091
4604 Liver carboxylesterase 1 CES1 0.0089
4916 Cyanoglobin glbN 0.0086
4943 Cytochrome c6 petJ 0.0085
4954 Soluble cytochrome b558 Not Available 0.0085
4934 Cytochrome c-551 nirM 0.0085
5218 Cytochrome c-551 nirM 0.0085
4936 Cytochrome c2 iso-2 Not Available 0.0085
4994 Hemoglobin-like protein HbO glbO 0.0085
4915 Cytochrome c-550 psbV 0.0085
4959 Cytochrome c-550 psbV 0.0085
5216 Cytochrome c-550 psbV 0.0085
4925 Cytochrome c-type protein SHP shp 0.0085
4947 Bacterial hemoglobin vhb 0.0085
4905 Cytochrome c2 Not Available 0.0085
4939 Cytochrome c2 cycA 0.0085
4964 Cytochrome c2 cycA 0.0085
4979 Cytochrome c2 cycA 0.0085
6673 Cytochrome c2 cycA 0.0085
4975 Cytochrome c-556 RPA3973 0.0085
4942 Diheme cytochrome c napB napB 0.0085
4984 Neuroglobin NGB 0.0085
3116 Bacterioferritin bfr 0.0085
4906 Bacterioferritin bfr 0.0085
4965 Bacterioferritin bfr 0.0085
4989 Cytochrome c551 peroxidase ccp 0.0085
5222 Cytochrome c551 peroxidase ccpA 0.0085
4961 Hemophore HasA hasA 0.0085
4910 Cytoglobin CYGB 0.0085
4976 Apocytochrome f petA 0.0085
6407 Apocytochrome f petA 0.0085
4907 Cytochrome c-L moxG 0.0085
6865 Cytochrome c-L moxG 0.0085
4981 Iron-starvation protein PigA pigA 0.0085
4909 CooA protein cooA 0.0085
5000 HemO hemO 0.0085
4971 Nonaheme cytochrome c hmcA 0.0085
4935 Cytochrome c-554 cycA1 0.0085
4931 Cytochrome P450 167A1 CYP167A1 0.0085
4926 Heme-based aerotactic transducer hemAT hemAT 0.0085
4904 Cytochrome c family protein GSU1996 0.0085
4922 Cytochrome c, putative SO_4144 0.0085
4903 Methyl-accepting chemotaxis protein Tar4 0.0085
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0085
4998 Hemoglobin-like protein yjbI yjbI 0.0085
4937 Cytochrome oxidase subunit II rcoxA 0.0085
4993 Hydroxylamine oxidoreductase hao1 0.0085
4999 Cytochrome P450 165B3 CYP165B3 0.0085
4972 P450cin cinA 0.0085
4764 Cytochrome P450 165C4 CYP165C4 0.0085
4960 Putative cytochrome P450-family protein SCO7417 0.0085
3093 Catalase HPII katE 0.0085
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0085
4952 Catalase/peroxidase katA 0.0085
644 Heme oxygenase 2 HMOX2 0.0085
4982 Heme oxygenase 2 pbsA2 0.0085
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0077
3375 Acidic cytochrome c3 Not Available 0.0075
4923 Cytochrome c3 DvMF_2499 0.0074
4945 Cytochrome c3 Not Available 0.0074
4949 Cytochrome c3 DVU_3171 0.0074
4968 Cytochrome c3 cytc3 0.0074
4997 Cytochrome c3 SO_2727 0.0074
5219 Cytochrome c3 cyd 0.0074
4813 Heme oxygenase hmuO 0.0074
5769 Heme oxygenase Not Available 0.0074
4385 Cytochrome c' Not Available 0.0074
4967 Cytochrome c' cycA 0.0074
5038 Cytochrome c' Not Available 0.0074
5223 Cytochrome c' cycP 0.0074
4037 Hypothetical protein GPX1 0.0074
4297 Hypothetical protein SP_1951 0.0074
4521 Hypothetical protein BC_2969 0.0074
4540 Hypothetical protein TM_1070 0.0074
4555 Hypothetical protein MT1739 0.0074
4569 Hypothetical protein mshD 0.0074
4578 Hypothetical protein PA3270 0.0074
4747 Hypothetical protein PA3967 0.0074
5177 Hypothetical protein TM_0096 0.0074
5194 Hypothetical protein PA1204 0.0074
5240 Hypothetical protein Rv2991 0.0074
5370 Hypothetical protein TM_1158 0.0074
5710 Hypothetical protein Tb927.5.1360 0.0074
2915 Sensor protein fixL fixL 0.0074
4944 Sensor protein fixL fixL 0.0074
4948 Cytochrome c-553 Not Available 0.0074
4289 Cytochrome P450 TT_P0059 0.0074
6262 Cytochrome P450 staP 0.0074
4902 Nine-heme cytochrome c Ddes_2038 0.0074
2119 Cytochrome b5 CYB5A 0.0074
3189 High-molecular-weight cytochrome c hmcA 0.0074
4992 Cytochrome c peroxidase Not Available 0.0074
3570 Cytochrome P450 152A1 cypC 0.0074
4920 Peroxidase/catalase katG 0.0074
4988 Sulfite oxidase, mitochondrial SUOX 0.0074
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0074
776 Bile salt export pump ABCB11 0.0071
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.007
3670 Soluble cytochrome b562 precursor cybC 0.0069
4386 Hemoglobin-like protein HbN glbN 0.0069
3291 Cytochrome c-552 cycA 0.0068
4927 Cytochrome c-552 nrfA 0.0068
4938 Cytochrome c-552 cycA 0.0068
4953 Cytochrome c-552 nrfA 0.0068
5217 Cytochrome c-552 cycM 0.0068
2617 Nitric oxide synthase oxygenase nos 0.0068
2701 Nitric oxide synthase oxygenase nos 0.0068
3411 Cytochrome P450 121 cyp121 0.0068
3102 Flavohemoprotein hmp 0.0068
4969 Flavohemoprotein hmp 0.0068
2230 Catalase CAT 0.0067
3249 Catalase katA 0.0067
3625 Catalase katA 0.0067
4539 Catalase katA 0.0067
4941 Catalase katB 0.0067
2164 Multidrug resistance-associated protein 4 ABCC4 0.0065
6143 Solute carrier family 22 member 7 SLC22A7 0.0065
3221 Cytochrome c4 cc4 0.0065
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0065
3127 Nitrite reductase nirS 0.0064
3284 Nitrite reductase nirS 0.0064
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0064
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0064
2972 6-deoxyerythronolide B hydroxylase eryF 0.0062
4608 Putative cytochrome P450 SCO1207 0.0062
4963 Putative cytochrome P450 SCO2884 0.0062
6254 Putative cytochrome P450 SCO6998 0.0062
605 Fumarate reductase flavoprotein subunit frdA 0.0061
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0061
3673 Fumarate reductase flavoprotein subunit fccA 0.0061
4912 Fumarate reductase flavoprotein subunit ifcA 0.0061
6549 Fumarate reductase flavoprotein subunit frdA 0.0061
6142 Solute carrier family 22 member 8 SLC22A8 0.006
518 Peroxidase/catalase T katG 0.0059
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0059
260 Cytochrome P450 51 ERG11 0.0058
761 Cytochrome P450 51 ERG11 0.0058
3163 Cytochrome P450 51 cyp51 0.0058
1507 Cytochrome c CYCS 0.0056
693 Hemoglobin subunit beta HBB 0.0054
6268 Hydroxyacid oxidase 1 HAO1 0.0054
358 Cystathionine beta-synthase CBS 0.0052
810 Heme oxygenase 1 HMOX1 0.0052
3391 Heme oxygenase 1 pbsA1 0.0052
2298 Cytochrome P450-cam camC 0.0047
1588 Multidrug resistance protein 1 ABCB1 0.0046
76 Nitric-oxide synthase, brain NOS1 0.0044
275 Arachidonate 5-lipoxygenase ALOX5 0.0042
7 Nitric oxide synthase, inducible NOS2 0.004
291 Nitric-oxide synthase, endothelial NOS3 0.0039
6106 Cytochrome P450 2C18 CYP2C18 0.0036
290 Prostaglandin G/H synthase 2 PTGS2 0.0031
20 Prostaglandin G/H synthase 1 PTGS1 0.0029
587 Serum albumin ALB 0.0027
6030 Cytochrome P450 2B6 CYP2B6 0.0027
4924 Cytochrome P450 2C8 CYP2C8 0.0025
4757 Cytochrome P450 2C9 CYP2C9 0.0023
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