DT-Web

DB00360 - Tetrahydrobiopterin


Identification
Name Tetrahydrobiopterin
Accession Number DB00360 (APRD01297)
Type small molecule
Description Tetrahydrobiopterin or BH4 is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 241.2471
Groups approved
Monoisotopic Weight 241.117489371
Pharmacology
Indication For the treatment of tetrahydrobiopterin (BH4) deficiency.
Mechanism of action Tetrahydrobiopterin (BH4) is a natural co-factor or co-enzyme for phenylalanine-4-hydroxylase (PAH),Tetrahydrobiopterine, and tryptophan-5-hydroxylase. Tetrahydrobiopterin is also a natural co-factor for nitrate oxide synthase. Therefore BH4 is required for the conversion of phenylalanine to tyrosine, for the production of epinephrine (adrenaline) and the synthesis of the monoamine neuro-transmitters, serotonin, dopamine, and norepinephrine (noradrenaline). It is also involved in apoptosis and other cellular events mediated by nitric oxide production. As a coenzyme, BH4 reacts with molecular oxygen to form an active oxygen intermediate that can hydroxylate substrates. In the hydroxylation process, the co-enzyme loses two electrons and is regenerated in vivo in an NADH-dependent reaction. As a co-factor for PAH, tetrahydrobiopterin allows the conversion of phenylalanine to tyrosine and reduces the level of phenylalanine in the bloodstream, thereby reducing the toxic effects of of this amino acid. Normal serum concentrations of phenylalanine are 100 micomolar, while elevated (toxic) levels are typically >1200 micromolar. Individuals with a deficiency in tetrahydrobiopterin are not able to efficiently convert phenylalanine to tyrosine. The excess levels provided by tetrahydrobiopterin supplementation help improve enzyme efficiency. As a co-factor for tyrosine hydroxylase, BH4 facilitates the conversion of tyrosine to L-dopa while as a co-factor for tryptophan hydroxylase, BH4 allows the conversion of tryptophan to 5-hydroxytryptophan, which is then converted to serotonin.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Nitric-oxide synthase, endothelial
Name Nitric-oxide synthase, endothelial
Gene Name NOS3
Pharmacological action yes
Actions cofactor
References
  • Heller R, Munscher-Paulig F, Grabner R, Till U: L-Ascorbic acid potentiates nitric oxide synthesis in endothelial cells. J Biol Chem. 1999 Mar 19;274(12):8254-60. - Pubmed
  • Huang A, Vita JA, Venema RC, Keaney JF Jr: Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin. J Biol Chem. 2000 Jun 9;275(23):17399-406. - Pubmed
  • Berka V, Tsai AL: Characterization of interactions among the heme center, tetrahydrobiopterin, and L-arginine binding sites of ferric eNOS using imidazole, cyanide, and nitric oxide as probes. Biochemistry. 2000 Aug 8;39(31):9373-83. - Pubmed
  • Gorren AC, Bec N, Schrammel A, Werner ER, Lange R, Mayer B: Low-temperature optical absorption spectra suggest a redox role for tetrahydrobiopterin in both steps of nitric oxide synthase catalysis. Biochemistry. 2000 Sep 26;39(38):11763-70. - Pubmed
  • Shinozaki K, Nishio Y, Okamura T, Yoshida Y, Maegawa H, Kojima H, Masada M, Toda N, Kikkawa R, Kashiwagi A: Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats. Circ Res. 2000 Sep 29;87(7):566-73. - Pubmed
  • Gorren AC, Mayer B: Tetrahydrobiopterin in nitric oxide synthesis: a novel biological role for pteridines. Curr Drug Metab. 2002 Apr;3(2):133-57. - Pubmed
DTHybrid score 1.2318
Phenylalanine-4-hydroxylase
Name Phenylalanine-4-hydroxylase
Gene Name PAH
Pharmacological action yes
Actions cofactor
References
  • Zekanowski C, Nowacka M, Sendecka E, Sowik M, Cabalska B, Bal J: Identification of Mutations Causing 6-Pyruvoyl- Tetrahydrobiopterin Synthase Deficiency in Polish Patients With Variant Hyperphenylalaninemia. Mol Diagn. 1998 Dec;3(4):237-239. - Pubmed
  • Werner ER, Habisch HJ, Gorren AC, Schmidt K, Canevari L, Werner-Felmayer G, Mayer B: Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine hydroxylase, dihydropteridine reductase and nitric oxide synthase. Biochem J. 2000 Jun 15;348 Pt 3:579-83. - Pubmed
  • Fitzpatrick PF: Tetrahydropterin-dependent amino acid hydroxylases. Annu Rev Biochem. 1999;68:355-81. - Pubmed
  • Ayling JE, Bailey SW, Boerth SR, Giugliani R, Braegger CP, Thony B, Blau N: Hyperphenylalaninemia and 7-pterin excretion associated with mutations in 4a-hydroxy-tetrahydrobiopterin dehydratase/DCoH: analysis of enzyme activity in intestinal biopsies. Mol Genet Metab. 2000 Jul;70(3):179-88. - Pubmed
  • Jennings IG, Teh T, Kobe B: Essential role of the N-terminal autoregulatory sequence in the regulation of phenylalanine hydroxylase. FEBS Lett. 2001 Jan 19;488(3):196-200. - Pubmed
DTHybrid score 0.7917
Tyrosine 3-monooxygenase
Name Tyrosine 3-monooxygenase
Gene Name TH
Pharmacological action yes
Actions cofactor
References
  • Koshimura K, Tanaka J, Murakami Y, Kato Y: Enhancement of neuronal survival by 6R-tetrahydrobiopterin. Neuroscience. 1999 Jan;88(2):561-9. - Pubmed
  • Flatmark T, Almas B, Knappskog PM, Berge SV, Svebak RM, Chehin R, Muga A, Martinez A: Tyrosine hydroxylase binds tetrahydrobiopterin cofactor with negative cooperativity, as shown by kinetic analyses and surface plasmon resonance detection. Eur J Biochem. 1999 Jun;262(3):840-9. - Pubmed
  • Ichinose H, Ohye T, Suzuki T, Inagaki H, Nagatsu T: [The relation between metabolism of biopterin and dystonia-parkinsonism] Nihon Shinkei Seishin Yakurigaku Zasshi. 1999 Apr;19(2):85-9. - Pubmed
  • Schwarz EJ, Alexander GM, Prockop DJ, Azizi SA: Multipotential marrow stromal cells transduced to produce L-DOPA: engraftment in a rat model of Parkinson disease. Hum Gene Ther. 1999 Oct 10;10(15):2539-49. - Pubmed
  • Schallreuter KU: A review of recent advances on the regulation of pigmentation in the human epidermis. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):943-9. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.9149
Tryptophan 5-hydroxylase 1
Name Tryptophan 5-hydroxylase 1
Gene Name TPH1
Pharmacological action yes
Actions cofactor
References
  • Chamas F, Serova L, Sabban EL: Tryptophan hydroxylase mRNA levels are elevated by repeated immobilization stress in rat raphe nuclei but not in pineal gland. Neurosci Lett. 1999 Jun 4;267(3):157-60. - Pubmed
  • Martinez A, Knappskog PM, Haavik J: A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis. Curr Med Chem. 2001 Jul;8(9):1077-91. - Pubmed
  • Ikemoto K, Suzuki T, Ichinose H, Ohye T, Nishimura A, Nishi K, Nagatsu I, Nagatsu T: Localization of sepiapterin reductase in the human brain. Brain Res. 2002 Nov 8;954(2):237-46. - Pubmed
  • Serova LI, Maharjan S, Huang A, Sun D, Kaley G, Sabban EL: Response of tyrosine hydroxylase and GTP cyclohydrolase I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration. Brain Res. 2004 Jul 23;1015(1-2):1-8. - Pubmed
  • Haavik J: [From butterflies to neurobiology and the diagnosis of AIDS. The 100th anniversary of the discovery of pteridines] Tidsskr Nor Laegeforen. 1989 Jun 30;109(19-21):1986-9. - Pubmed
DTHybrid score 0.4386

Enzymes


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Actions inducer
References
  • Chae SW, Bang YJ, Kim KM, Lee KY, Kang BY, Kim EM, Inoue H, Hwang O, Choi HJ: Role of cyclooxygenase-2 in tetrahydrobiopterin-induced dopamine oxidation. Biochem Biophys Res Commun. 2007 Aug 3;359(3):735-41. Epub 2007 Jun 4. - Pubmed
DTHybrid score 0.4466

Predictions


Id Partner name Gene Name Score
3109 Phenylalanine-4-hydroxylase phhA 0.7917
7 Nitric oxide synthase, inducible NOS2 0.3229
76 Nitric-oxide synthase, brain NOS1 0.2315
20 Prostaglandin G/H synthase 1 PTGS1 0.1694
5666 Parathyroid hormone PTH 0.1158
6151 Monocarboxylate transporter 10 SLC16A10 0.089
763 Tyrosine aminotransferase TAT 0.0854
5493 Tyrosine aminotransferase Not Available 0.0854
2675 Pteridine reductase 1 PTR1 0.0816
2360 Dihydroneopterin aldolase folB 0.0684
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0677
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0677
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0677
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0677
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0677
199 Monocarboxylate transporter 8 SLC16A2 0.0665
90 Tryptophan 5-hydroxylase 2 TPH2 0.0584
399 Tyrosyl-tRNA synthetase, mitochondrial YARS2 0.0568
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0538
4757 Cytochrome P450 2C9 CYP2C9 0.0473
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0462
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0452
765 Indoleamine 2,3-dioxygenase IDO1 0.0451
6012 Tryptophan 2,3-dioxygenase TDO2 0.0444
2452 Tryptophanyl-tRNA synthetase trpS 0.042
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0411
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0389
1729 Solute carrier family 22 member 6 SLC22A6 0.0322
4200 Cytochrome P450 1A2 CYP1A2 0.0275
587 Serum albumin ALB 0.0263
4512 Cytochrome P450 3A4 CYP3A4 0.0253
298 Renin REN 0.0221
789 Alpha-1D adrenergic receptor ADRA1D 0.0203
864 Gag-Pol polyprotein gag-pol 0.0197
2237 Gag-Pol polyprotein gag-pol 0.0197
2326 Gag-Pol polyprotein gag-pol 0.0197
2451 Gag-Pol polyprotein gag-pol 0.0197
2901 Gag-Pol polyprotein gag-pol 0.0197
3165 Gag-Pol polyprotein gag-pol 0.0197
3722 Gag-Pol polyprotein gag-pol 0.0197
6306 Gag-Pol polyprotein gag-pol 0.0197
6624 Gag-Pol polyprotein gag-pol 0.0197
275 Arachidonate 5-lipoxygenase ALOX5 0.0197
1757 Myeloperoxidase MPO 0.0192
629 Alpha-2B adrenergic receptor ADRA2B 0.0191
193 Beta-1 adrenergic receptor ADRB1 0.0188
1159 Interleukin-6 IL6 0.0185
766 Beta-2 adrenergic receptor ADRB2 0.0183
4924 Cytochrome P450 2C8 CYP2C8 0.0182
1517 Beta-3 adrenergic receptor ADRB3 0.018
632 Alpha-1B adrenergic receptor ADRA1B 0.0179
318 Alpha-2A adrenergic receptor ADRA2A 0.017
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0164
556 Alpha-1A adrenergic receptor ADRA1A 0.0159
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0152
2617 Nitric oxide synthase oxygenase nos 0.0143
2701 Nitric oxide synthase oxygenase nos 0.0143
672 Prostaglandin F2-alpha receptor PTGFR 0.0135
6142 Solute carrier family 22 member 8 SLC22A8 0.0133
378 Alpha-2C adrenergic receptor ADRA2C 0.0129
118 Organic cation/carnitine transporter 2 SLC22A5 0.0127
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0126
6016 Cytochrome P450 2C19 CYP2C19 0.0125
822 Aldose reductase AKR1B1 0.0122
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0119
2164 Multidrug resistance-associated protein 4 ABCC4 0.0117
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0117
1588 Multidrug resistance protein 1 ABCB1 0.0115
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0114
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
3312 Fatty acid-binding protein, brain FABP7 0.0113
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0112
1024 Solute carrier family 22 member 11 SLC22A11 0.0109
6144 Solute carrier family 22 member 2 SLC22A2 0.0109
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0103
2939 Peptide methionine sulfoxide reductase msrA msrA 0.0102
2888 DNA-repair protein XRCC4 XRCC4 0.0102
2906 Coatomer subunit gamma COPG 0.0102
6013 Cytochrome P450 2E1 CYP2E1 0.01
6145 Solute carrier family 22 member 1 SLC22A1 0.01
3923 Cholinesterase BCHE 0.0099
777 Tumor necrosis factor TNF 0.0098
315 Arginase-1 ARG1 0.0097
1439 Lactotransferrin LTF 0.0095
6220 Aryl hydrocarbon receptor AHR 0.0094
2090 Toll-like receptor 2 TLR2 0.0091
373 Transthyretin TTR 0.009
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
2433 Capsid protein P40 UL80 0.0082
3569 Capsid protein P40 BVRF2 0.0082
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
3947 Xanthine dehydrogenase/oxidase XDH 0.0078
703 NADPH azoreductase azr 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0071
850 Vasopressin V1b receptor AVPR1B 0.007
2297 Genome polyprotein Not Available 0.0069
2322 Genome polyprotein Not Available 0.0069
2694 Genome polyprotein Not Available 0.0069
2719 Genome polyprotein Not Available 0.0069
2860 Genome polyprotein Not Available 0.0069
2928 Genome polyprotein Not Available 0.0069
3160 Genome polyprotein Not Available 0.0069
3260 Genome polyprotein Not Available 0.0069
4783 Genome polyprotein Not Available 0.0069
5726 Genome polyprotein Not Available 0.0069
5779 Genome polyprotein Not Available 0.0069
5867 Genome polyprotein Not Available 0.0069
6253 Genome polyprotein Not Available 0.0069
6301 Genome polyprotein Not Available 0.0069
6380 Genome polyprotein Not Available 0.0069
6381 Genome polyprotein Not Available 0.0069
6437 Genome polyprotein Not Available 0.0069
6520 Genome polyprotein Not Available 0.0069
6521 Genome polyprotein Not Available 0.0069
6652 Genome polyprotein Not Available 0.0069
6734 Genome polyprotein Not Available 0.0069
6735 Genome polyprotein Not Available 0.0069
6736 Genome polyprotein Not Available 0.0069
6737 Genome polyprotein Not Available 0.0069
6738 Genome polyprotein Not Available 0.0069
6739 Genome polyprotein Not Available 0.0069
6744 Genome polyprotein Not Available 0.0069
6748 Genome polyprotein Not Available 0.0069
6894 Genome polyprotein Not Available 0.0069
6898 Genome polyprotein Not Available 0.0069
6143 Solute carrier family 22 member 7 SLC22A7 0.0067
740 Argininosuccinate synthase ASS1 0.0067
865 Argininosuccinate synthase ASS1 0.0067
2680 Argininosuccinate synthase argG 0.0067
3194 Argininosuccinate synthase argG 0.0067
146 Androgen receptor AR 0.0066
661 ADP/ATP translocase 1 SLC25A4 0.0064
185 Vasopressin V1a receptor AVPR1A 0.0061
3823 Cytokine receptor common gamma chain IL2RG 0.0061
723 Cytosolic phospholipase A2 PLA2G4A 0.006
322 Vasopressin V2 receptor AVPR2 0.006
4119 Cytochrome P450 2D6 CYP2D6 0.0059
6024 Cytochrome P450 1A1 CYP1A1 0.0059
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0057
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0056
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0056
6147 Solute carrier family 22 member 3 SLC22A3 0.0053
724 Interleukin-2 receptor alpha chain IL2RA 0.0053
717 Interleukin-2 receptor subunit beta IL2RB 0.0053
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0052
4132 Chloride channel protein ClC-Ka CLCNKA 0.0051
577 Argininosuccinate lyase ASL 0.0049
1648 Elastin ELN 0.0047
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0047
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0047
1814 Protein-arginine deiminase type-4 PADI4 0.0046
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0046
1656 CYP2B protein CYP2B 0.0045
737 Mineralocorticoid receptor NR3C2 0.0044
834 Arginase-2, mitochondrial ARG2 0.0044
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0044
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0043
843 NG,NG-dimethylarginine dimethylaminohydrolase 1 DDAH1 0.0043
670 NG,NG-dimethylarginine dimethylaminohydrolase 2 DDAH2 0.0043
4066 Protein-arginine deiminase type-1 PADI1 0.0043
4067 Protein-arginine deiminase type-3 PADI3 0.0043
4065 Protein-arginine deiminase type-6 PADI6 0.0043
4068 Protein-arginine deiminase type-2 PADI2 0.0043
6137 Multidrug resistance-associated protein 6 ABCC6 0.0043
6043 Putative G-protein coupled receptor 44 GPR44 0.0042
6030 Cytochrome P450 2B6 CYP2B6 0.0042
738 Monocarboxylate transporter 1 SLC16A1 0.0041
499 Arginine decarboxylase ADC 0.0041
3811 Cytochrome P450 19A1 CYP19A1 0.004
336 Ornithine carbamoyltransferase, mitochondrial OTC 0.004
4118 Cytochrome P450 3A5 CYP3A5 0.004
614 Progesterone receptor PGR 0.004
232 Corticosteroid-binding globulin SERPINA6 0.0039
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0039
6106 Cytochrome P450 2C18 CYP2C18 0.0039
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0038
58 Cationic amino acid transporter 4 SLC7A4 0.0038
150 Cationic amino acid transporter 3 SLC7A3 0.0038
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0038
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0038
862 Multidrug resistance-associated protein 1 ABCC1 0.0037
130 Prostacyclin synthase PTGIS 0.0037
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0036
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0036
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0035
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0034
871 Glucocorticoid receptor NR3C1 0.0033
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0033
759 Free fatty acid receptor 1 FFAR1 0.0032
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0032
6033 High affinity interleukin-8 receptor A CXCR1 0.0032
6102 Arylamine N-acetyltransferase 2 NAT2 0.0032
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0032
1898 Cytochrome P450 1B1 CYP1B1 0.0031
6500 Phospholipase A2 PLA2G1B 0.0031
489 Monocarboxylate transporter 2 SLC16A7 0.003
5718 Cytochrome P450 2A6 CYP2A6 0.003
1714 Mitogen-activated protein kinase 3 MAPK3 0.0028
1053 BC269730_2 FADS1 0.0028
1395 Sodium/calcium exchanger 1 SLC8A1 0.0028
823 Fibroblast growth factor receptor 2 FGFR2 0.0027
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0026
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0026
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0026
1650 Heme carrier protein 1 SLC46A1 0.0026
6141 Sodium/bile acid cotransporter SLC10A1 0.0026
3601 Dihydropteroate synthase 1 folP1 0.0025
3807 Dihydropteroate synthase 1 folP1 0.0025
3808 Dihydropteroate synthase 2 folP2 0.0025
833 Organic cation/carnitine transporter 1 SLC22A4 0.0025
310 Solute carrier family 12 member 2 SLC12A2 0.0024
908 Glutathione S-transferase theta-1 GSTT1 0.0024
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0024
6149 Solute carrier family 22 member 10 SLC22A10 0.0024
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
6148 Multidrug resistance-associated protein 7 ABCC10 0.0023
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0023
33 Cystine/glutamate transporter SLC7A11 0.0023
2782 Complement C1s subcomponent C1S 0.0022
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0022
817 DNA topoisomerase 2-alpha TOP2A 0.0021
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0021
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0021
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0021
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0021
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0021
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
3814 Complement C1r subcomponent C1R 0.0021
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.002
1181 Alpha-1-acid glycoprotein 1 ORM1 0.002
904 Glutathione S-transferase P GSTP1 0.002
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0019
558 Solute carrier family 12 member 1 SLC12A1 0.0019
2981 Phospholipase A2, membrane associated PLA2G2A 0.0017
6168 Solute carrier family 22 member 16 SLC22A16 0.0017
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0017
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0017
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0017
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0017
2021 Thrombomodulin THBD 0.0016
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0016
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0016
1192 Sulfotransferase 1A1 SULT1A1 0.0015
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0015
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0015
1275 Estrogen sulfotransferase SULT1E1 0.0015
1050 Bile salt sulfotransferase SULT2A1 0.0014
4120 NADPH--cytochrome P450 reductase POR 0.0014
4192 DNA topoisomerase 2-beta TOP2B 0.0014
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0013
260 Cytochrome P450 51 ERG11 0.0013
761 Cytochrome P450 51 ERG11 0.0013
3163 Cytochrome P450 51 cyp51 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0013
4943 Cytochrome c6 petJ 0.0012
4905 Cytochrome c2 Not Available 0.0012
4939 Cytochrome c2 cycA 0.0012
4964 Cytochrome c2 cycA 0.0012
4979 Cytochrome c2 cycA 0.0012
6673 Cytochrome c2 cycA 0.0012
4954 Soluble cytochrome b558 Not Available 0.0012
4934 Cytochrome c-551 nirM 0.0012
5218 Cytochrome c-551 nirM 0.0012
4984 Neuroglobin NGB 0.0012
4916 Cyanoglobin glbN 0.0012
4994 Hemoglobin-like protein HbO glbO 0.0012
4925 Cytochrome c-type protein SHP shp 0.0012
4998 Hemoglobin-like protein yjbI yjbI 0.0012
4947 Bacterial hemoglobin vhb 0.0012
4942 Diheme cytochrome c napB napB 0.0012
4936 Cytochrome c2 iso-2 Not Available 0.0012
4915 Cytochrome c-550 psbV 0.0012
4959 Cytochrome c-550 psbV 0.0012
5216 Cytochrome c-550 psbV 0.0012
4961 Hemophore HasA hasA 0.0012
4910 Cytoglobin CYGB 0.0012
4975 Cytochrome c-556 RPA3973 0.0012
5000 HemO hemO 0.0012
3116 Bacterioferritin bfr 0.0012
4906 Bacterioferritin bfr 0.0012
4965 Bacterioferritin bfr 0.0012
644 Heme oxygenase 2 HMOX2 0.0012
4982 Heme oxygenase 2 pbsA2 0.0012
4907 Cytochrome c-L moxG 0.0012
6865 Cytochrome c-L moxG 0.0012
4981 Iron-starvation protein PigA pigA 0.0012
4904 Cytochrome c family protein GSU1996 0.0012
4764 Cytochrome P450 165C4 CYP165C4 0.0012
4909 CooA protein cooA 0.0012
4935 Cytochrome c-554 cycA1 0.0012
4971 Nonaheme cytochrome c hmcA 0.0012
4972 P450cin cinA 0.0012
4960 Putative cytochrome P450-family protein SCO7417 0.0012
4989 Cytochrome c551 peroxidase ccp 0.0012
5222 Cytochrome c551 peroxidase ccpA 0.0012
4976 Apocytochrome f petA 0.0012
6407 Apocytochrome f petA 0.0012
4937 Cytochrome oxidase subunit II rcoxA 0.0012
4931 Cytochrome P450 167A1 CYP167A1 0.0012
4999 Cytochrome P450 165B3 CYP165B3 0.0012
4926 Heme-based aerotactic transducer hemAT hemAT 0.0012
4993 Hydroxylamine oxidoreductase hao1 0.0012
4922 Cytochrome c, putative SO_4144 0.0012
4952 Catalase/peroxidase katA 0.0012
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0012
3093 Catalase HPII katE 0.0012
4903 Methyl-accepting chemotaxis protein Tar4 0.0012
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0012
6042 Prostaglandin reductase 2 PTGR2 0.0012
6163 Copper-transporting ATPase 2 ATP7B 0.0012
6165 Copper-transporting ATPase 1 ATP7A 0.0012
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0012
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
1792 Tissue-type plasminogen activator PLAT 0.0011
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0011
273 Apoptosis regulator Bcl-2 BCL2 0.0011
6085 Fatty acid-binding protein, intestinal FABP2 0.0011
776 Bile salt export pump ABCB11 0.0011
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.001
4920 Peroxidase/catalase katG 0.001
4037 Hypothetical protein GPX1 0.001
4297 Hypothetical protein SP_1951 0.001
4521 Hypothetical protein BC_2969 0.001
4540 Hypothetical protein TM_1070 0.001
4555 Hypothetical protein MT1739 0.001
4569 Hypothetical protein mshD 0.001
4578 Hypothetical protein PA3270 0.001
4747 Hypothetical protein PA3967 0.001
5177 Hypothetical protein TM_0096 0.001
5194 Hypothetical protein PA1204 0.001
5240 Hypothetical protein Rv2991 0.001
5370 Hypothetical protein TM_1158 0.001
5710 Hypothetical protein Tb927.5.1360 0.001
468 Cytochrome P450 4A11 CYP4A11 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4289 Cytochrome P450 TT_P0059 0.001
6262 Cytochrome P450 staP 0.001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.001
2119 Cytochrome b5 CYB5A 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
4990 PpcA ppcA 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
3570 Cytochrome P450 152A1 cypC 0.001
4992 Cytochrome c peroxidase Not Available 0.001
896 Glutathione S-transferase Mu 1 GSTM1 0.001
4988 Sulfite oxidase, mitochondrial SUOX 0.001
2915 Sensor protein fixL fixL 0.001
4944 Sensor protein fixL fixL 0.001
4385 Cytochrome c' Not Available 0.001
4967 Cytochrome c' cycA 0.001
5038 Cytochrome c' Not Available 0.001
5223 Cytochrome c' cycP 0.001
3375 Acidic cytochrome c3 Not Available 0.001
4813 Heme oxygenase hmuO 0.001
5769 Heme oxygenase Not Available 0.001
1313 Lactoylglutathione lyase GLO1 0.0009
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0009
6107 Cytochrome P450 3A7 CYP3A7 0.0009
6136 Multidrug resistance-associated protein 5 ABCC5 0.0009
3670 Soluble cytochrome b562 precursor cybC 0.0009
3411 Cytochrome P450 121 cyp121 0.0009
3291 Cytochrome c-552 cycA 0.0009
4927 Cytochrome c-552 nrfA 0.0009
4938 Cytochrome c-552 cycA 0.0009
4953 Cytochrome c-552 nrfA 0.0009
5217 Cytochrome c-552 cycM 0.0009
4386 Hemoglobin-like protein HbN glbN 0.0009
3102 Flavohemoprotein hmp 0.0009
4969 Flavohemoprotein hmp 0.0009
2230 Catalase CAT 0.0009
3249 Catalase katA 0.0009
3625 Catalase katA 0.0009
4539 Catalase katA 0.0009
4941 Catalase katB 0.0009
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0008
3127 Nitrite reductase nirS 0.0008
3284 Nitrite reductase nirS 0.0008
3221 Cytochrome c4 cc4 0.0008
4608 Putative cytochrome P450 SCO1207 0.0008
4963 Putative cytochrome P450 SCO2884 0.0008
6254 Putative cytochrome P450 SCO6998 0.0008
605 Fumarate reductase flavoprotein subunit frdA 0.0008
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0008
3673 Fumarate reductase flavoprotein subunit fccA 0.0008
4912 Fumarate reductase flavoprotein subunit ifcA 0.0008
6549 Fumarate reductase flavoprotein subunit frdA 0.0008
2972 6-deoxyerythronolide B hydroxylase eryF 0.0008
518 Peroxidase/catalase T katG 0.0008
4604 Liver carboxylesterase 1 CES1 0.0007
1507 Cytochrome c CYCS 0.0007
693 Hemoglobin subunit beta HBB 0.0007
6268 Hydroxyacid oxidase 1 HAO1 0.0007
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
358 Cystathionine beta-synthase CBS 0.0006
2298 Cytochrome P450-cam camC 0.0006
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