DT-Web

DB01212 - Ceftriaxone


Identification
Name Ceftriaxone
Accession Number DB01212 (APRD00395)
Type small molecule
Description A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 554.58
Groups approved
Monoisotopic Weight 554.04605704
Pharmacology
Indication For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Mechanism of action Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of Ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. By binding to these enzymes, Ceftriaxone results in the formation of of defective cell walls and cell death.
Absorption Not Available
Protein binding 95%
Biotransformation Not Available
Route of elimination Thirty-three percent to 67% of a ceftriaxone dose was excreted in the urine as unchanged drug and the remainder was secreted in the bile and ultimately found in the feces as microbiologically inactive compounds.
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The cephalosporin, ceftriaxone, may increase the anticoagulant effect of acenocoumarol.
Amikacin Increased risk of nephrotoxicity
Anisindione The cephalosporin, ceftriaxone, may increase the anticoagulant effect of anisindione.
Calcium Acetate Calcium Salts (Intravenous) may enhance the adverse/toxic effect of Ceftriaxone. Ceftriaxone binds to calcium forming an insoluble precipitate. Concurrent or sequential use (within 48 hours) of ceftriaxone with calcium-containing solutions is contraindicated in neonates (28 days of age or younger). In other patients, these solutions can be used sequentially if the infusion lines are flushed with a compatible fluid between ceftriaxone and calcium-containing solution infusion.
Calcium Chloride Calcium Salts (Intravenous) may enhance the adverse/toxic effect of ceftriaxone. Ceftriaxone binds to calcium forming an insoluble precipitate. Concurrent or sequential use (within 48 hours) of ceftriaxone with calcium-containing solutions is contraindicated in neonates (28 days of age or younger). In other patients, these solutions can be used sequentially if the infusion lines are flushed with a compatible fluid between ceftriaxone and calcium-containing solution infusion.
Dicumarol The cephalosporin, ceftriaxone, may increase the anticoagulant effect of dicumarol.
Gentamicin Increased risk of nephrotoxicity
Kanamycin Increased risk of nephrotoxicity
Neomycin Increased risk of nephrotoxicity
Netilmicin Increased risk of nephrotoxicity
Streptomycin Increased risk of nephrotoxicity
Tobramycin Increased risk of nephrotoxicity
Warfarin The cephalosporin, ceftriaxone, may increase the anticoagulant effect of warfarin.
Food Interactions Not Available

Targets


Penicillin-binding protein 2B
Name Penicillin-binding protein 2B
Gene Name penA
Pharmacological action yes
Actions inhibitor
References
  • Tomberg J, Unemo M, Davies C, Nicholas RA: Molecular and Structural Analysis of Mosaic Variants of Penicillin-Binding Protein 2 Conferring Decreased Susceptibility to Expanded-Spectrum Cephalosporins in Neisseria gonorrhoeae: Role of Epistatic Mutations. Biochemistry. 2010 Aug 25. - Pubmed
DTHybrid score 0.0175

Enzymes


Glutamine synthetase
Name Glutamine synthetase
Gene Name GLUL
Actions inducer
References
  • Tumani H, Smirnov A, Barchfeld S, Olgemoller U, Maier K, Lange P, Bruck W, Nau R: Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus. Glia. 2000 Mar;30(1):11-8. - Pubmed
  • Verma R, Mishra V, Sasmal D, Raghubir R: Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated neuroprotection following cerebral ischemia/reperfusion injury. Eur J Pharmacol. 2010 Jul 25;638(1-3):65-71. Epub 2010 Apr 24. - Pubmed
DTHybrid score 0.3493

Transporters


Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions inhibitor
References
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
DTHybrid score 0.6176
Oligopeptide transporter, kidney isoform
Name Oligopeptide transporter, kidney isoform
Gene Name SLC15A2
Actions inhibitor
References
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
DTHybrid score 0.6034
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol. 2002 Mar 8;438(3):137-42. - Pubmed
  • Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. - Pubmed
  • Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. - Pubmed
DTHybrid score 0.5325
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol. 2002 Mar 8;438(3):137-42. - Pubmed
  • Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. - Pubmed
DTHybrid score 0.3951
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions inhibitor
References
  • Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol. 2002 Mar 8;438(3):137-42. - Pubmed
DTHybrid score 0.2941

Carriers


Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions
References Not Available
DTHybrid score 0.6176
Oligopeptide transporter, kidney isoform
Name Oligopeptide transporter, kidney isoform
Gene Name SLC15A2
Actions
References Not Available
DTHybrid score 0.6034
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions
References Not Available
DTHybrid score 0.5325
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions
References Not Available
DTHybrid score 0.3951
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions
References Not Available
DTHybrid score 0.2941

Predictions


Id Partner name Gene Name Score
3426 Glutamine synthetase glnA 0.3493
633 Penicillin-binding proteins 1A/1B pbpA 0.1838
244 Angiotensin-converting enzyme ACE 0.1824
118 Organic cation/carnitine transporter 2 SLC22A5 0.1658
6143 Solute carrier family 22 member 7 SLC22A7 0.1508
4512 Cytochrome P450 3A4 CYP3A4 0.1236
1588 Multidrug resistance protein 1 ABCB1 0.0939
4757 Cytochrome P450 2C9 CYP2C9 0.0883
645 Penicillin-binding protein 1A mrcA 0.0801
5805 Penicillin-binding protein 1A ponA 0.0801
6185 Penicillin-binding protein 1A mrcA 0.0801
6799 Penicillin-binding protein 1A pbpA 0.0801
20 Prostaglandin G/H synthase 1 PTGS1 0.0787
6016 Cytochrome P450 2C19 CYP2C19 0.0749
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0745
290 Prostaglandin G/H synthase 2 PTGS2 0.0728
1 Peptidoglycan synthetase ftsI ftsI 0.0718
4155 Peptidoglycan synthetase ftsI ftsI 0.0718
543 Penicillin-binding protein 1B mrcB 0.0677
6186 Penicillin-binding protein 1B ponB 0.0677
6822 Penicillin-binding protein 1b pbp1b 0.0677
6844 Penicillin-binding protein 1b pbp1b 0.0677
2164 Multidrug resistance-associated protein 4 ABCC4 0.0626
4924 Cytochrome P450 2C8 CYP2C8 0.0582
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0541
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0513
738 Monocarboxylate transporter 1 SLC16A1 0.0493
4200 Cytochrome P450 1A2 CYP1A2 0.049
4119 Cytochrome P450 2D6 CYP2D6 0.0427
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0418
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0384
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.038
6145 Solute carrier family 22 member 1 SLC22A1 0.0362
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0361
862 Multidrug resistance-associated protein 1 ABCC1 0.0358
22 30S ribosomal protein S4 rpsD 0.0357
6714 30S ribosomal protein S4 rpsD 0.0357
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0351
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0351
1385 Angiotensin-converting enzyme 2 ACE2 0.035
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0344
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0339
140 30S ribosomal protein S9 rpsI 0.0336
6719 30S ribosomal protein S9 rpsI 0.0336
6725 30S ribosomal protein S9 rpsI 0.0336
6024 Cytochrome P450 1A1 CYP1A1 0.0336
3923 Cholinesterase BCHE 0.0335
6144 Solute carrier family 22 member 2 SLC22A2 0.0328
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0328
3917 Methylenetetrahydrofolate reductase MTHFR 0.0323
85 Growth hormone receptor GHR 0.0319
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0315
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0313
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0308
4118 Cytochrome P450 3A5 CYP3A5 0.0306
338 DNA polymerase UL30 0.0303
379 DNA polymerase UL54 0.0303
697 DNA polymerase ORF28 0.0303
2482 DNA polymerase 43 0.0303
4104 DNA polymerase BALF5 0.0303
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.03
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.03
295 Carbonic anhydrase 1 CA1 0.0298
1757 Myeloperoxidase MPO 0.0296
357 Carbonic anhydrase 2 CA2 0.0296
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.029
4604 Liver carboxylesterase 1 CES1 0.0286
3760 Penicillin-binding protein 5 precursor dacA 0.0285
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0278
6106 Cytochrome P450 2C18 CYP2C18 0.0278
6067 Penicillin binding protein 2a mecA 0.0271
867 Penicillin-binding protein 3 pbpC 0.0271
6119 Penicillin-binding protein 3 pbp3 0.0271
7154 Penicillin-binding protein 3 pbp3 0.0271
7157 Penicillin-binding protein 3 LMHCC_2184 0.0271
7162 Penicillin-binding protein 3 pbpB 0.0271
7172 Penicillin-binding protein 3 pbp3 0.0271
833 Organic cation/carnitine transporter 1 SLC22A4 0.0269
776 Bile salt export pump ABCB11 0.0264
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0251
438 Taste receptor type 1 member 2 TAS1R2 0.0248
461 Glycine receptor subunit alpha-3 GLRA3 0.0246
820 Glycine receptor subunit alpha-2 GLRA2 0.0246
234 Plasminogen PLG 0.0246
466 Solute carrier family 12 member 3 SLC12A3 0.0239
6141 Sodium/bile acid cotransporter SLC10A1 0.0238
115 Penicillin-binding protein 2 mrdA 0.0235
6069 Penicillin-binding protein 2 mrdA 0.0235
6118 Penicillin-binding protein 2 penA 0.0235
6187 Penicillin-binding protein 2 pbpA 0.0235
6686 Penicillin-binding protein 2 pbp2 0.0235
6939 Penicillin-binding protein 2 mrdA 0.0235
7163 Penicillin-binding protein 2 pbpA 0.0235
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0232
23 D(1A) dopamine receptor DRD1 0.0231
56 Delta-aminolevulinic acid dehydratase ALAD 0.023
2356 Delta-aminolevulinic acid dehydratase hemB 0.023
3613 Delta-aminolevulinic acid dehydratase hemB 0.023
3674 Delta-aminolevulinic acid dehydratase hemB 0.023
556 Alpha-1A adrenergic receptor ADRA1A 0.0229
318 Alpha-2A adrenergic receptor ADRA2A 0.0227
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0221
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0219
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0217
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0215
502 5-hydroxytryptamine 2A receptor HTR2A 0.0213
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0213
6136 Multidrug resistance-associated protein 5 ABCC5 0.0211
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0209
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0208
891 Dihydropteroate synthase folP 0.0207
5359 Dihydropteroate synthase folP 0.0207
7175 Dihydropteroate synthase sulI 0.0207
558 Solute carrier family 12 member 1 SLC12A1 0.0207
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0206
887 DNA gyrase subunit B gyrB 0.0201
4150 DNA gyrase subunit B gyrB 0.0201
6225 DNA gyrase subunit B gyrB 0.0201
2544 Bacterial leucyl aminopeptidase Not Available 0.0198
2016 Dipeptidase 1 DPEP1 0.0197
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0196
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0196
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0192
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0186
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0184
5353 Glutamate decarboxylase alpha gadA 0.0183
6030 Cytochrome P450 2B6 CYP2B6 0.0182
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0181
819 Penicillin-binding protein 4 dacB 0.0181
6107 Cytochrome P450 3A7 CYP3A7 0.0178
6149 Solute carrier family 22 member 10 SLC22A10 0.0175
159 Penicillin-binding protein 2B penA 0.0175
6151 Monocarboxylate transporter 10 SLC16A10 0.0175
4252 Penicillin-binding protein 5 dacA 0.0171
1389 Transforming growth factor beta-1 TGFB1 0.0169
6013 Cytochrome P450 2E1 CYP2E1 0.0168
1867 Major prion protein PRNP 0.0163
509 Thymidine kinase TK 0.0161
570 Thymidine kinase TK 0.0161
2559 Thymidine kinase TK 0.0161
3430 Thymidine kinase tdk 0.0161
3518 Thymidine kinase TK 0.0161
5301 Thymidine kinase tdk 0.0161
5771 Thymidine kinase ORF36 0.0161
7009 Thymidine kinase ORF36 0.0161
468 Cytochrome P450 4A11 CYP4A11 0.016
332 Beta-lactamase blaZ 0.0159
2478 Beta-lactamase ampC 0.0159
2613 Beta-lactamase ampC 0.0159
2635 Beta-lactamase ampC 0.0159
2700 Beta-lactamase penP 0.0159
5445 Beta-lactamase blaB 0.0159
6019 Beta-lactamase SHV-7 0.0159
6701 Beta-lactamase cphA 0.0159
592 Carbonic anhydrase 4 CA4 0.0159
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
3060 Leukotriene A-4 hydrolase LTA4H 0.0149
6147 Solute carrier family 22 member 3 SLC22A3 0.0146
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
6541 Peptostreptococcal albumin-binding protein pab 0.0142
6209 30S ribosomal protein S19 rpsS 0.0141
6712 30S ribosomal protein S19 rpsS 0.0141
6726 30S ribosomal protein S19 rpsS 0.0141
6207 30S ribosomal protein S14 rpsN 0.0141
65 Matrix metalloproteinase-9 Not Available 0.014
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0139
317 Methionine-R-sulfoxide reductase SEPX1 0.0135
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0135
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0134
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0134
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0134
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0134
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0134
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0131
373 Transthyretin TTR 0.0128
5626 Nucleoside diphosphate kinase B NME2 0.0127
183 Vascular endothelial growth factor A VEGFA 0.0125
130 Prostacyclin synthase PTGIS 0.0124
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0123
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
6033 High affinity interleukin-8 receptor A CXCR1 0.0122
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0121
3810 Catechol O-methyltransferase COMT 0.012
1198 Serum paraoxonase/arylesterase 1 PON1 0.012
6223 Penicillin-binding protein 1C pbpC 0.012
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0117
1141 Sialidase-1 NEU1 0.0117
64 Neuraminidase NA 0.0117
641 Neuraminidase NA 0.0117
2676 Neuraminidase NA 0.0117
3026 Neuraminidase NA 0.0117
3519 Neuraminidase NA 0.0117
6007 Neuraminidase NA 0.0117
756 Sex hormone-binding globulin SHBG 0.0115
191 Peptide methionine sulfoxide reductase MSRA 0.0114
6148 Multidrug resistance-associated protein 7 ABCC10 0.0113
275 Arachidonate 5-lipoxygenase ALOX5 0.0113
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0112
2249 Aspartate aminotransferase aspC 0.0112
2671 Aspartate aminotransferase aspC 0.0112
5490 Aspartate aminotransferase Not Available 0.0112
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0112
3639 Thymidine phosphorylase deoA 0.0111
3936 Thymidine phosphorylase TYMP 0.0111
6167 Organic solute transporter subunit beta OSTB 0.0111
6166 Organic solute transporter subunit alpha OSTA 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
2320 Thymidine kinase, cytosolic TK1 0.011
1405 Thiopurine S-methyltransferase TPMT 0.0109
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0108
6085 Fatty acid-binding protein, intestinal FABP2 0.0107
5718 Cytochrome P450 2A6 CYP2A6 0.0107
124 Histamine H2 receptor HRH2 0.0107
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0103
6126 Carbonic anhydrase 7 CA7 0.0103
6020 Aldehyde oxidase AOX1 0.0103
5294 Nucleoside diphosphate kinase A NME1 0.0103
527 Prostacyclin receptor PTGIR 0.0102
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0101
840 Methionine synthase reductase, mitochondrial MTRR 0.01
672 Prostaglandin F2-alpha receptor PTGFR 0.0099
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0099
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0098
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0098
5 Glutaminase liver isoform, mitochondrial GLS2 0.0098
917 Glutaminase kidney isoform, mitochondrial GLS 0.0098
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0098
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0098
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0098
2211 Fatty acid-binding protein, heart FABP3 0.0098
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0098
5261 Phosphoribosylformylglycinamidine synthase purL 0.0098
632 Alpha-1B adrenergic receptor ADRA1B 0.0097
707 72 kDa type IV collagenase MMP2 0.0095
566 Serotransferrin TF 0.0094
809 Methionine synthase MTR 0.0094
2935 Methionine synthase metH 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
1654 Interleukin-1 beta IL1B 0.0092
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0091
5482 Sialidase-2 NEU2 0.0091
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0089
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0087
53 Solute carrier family 12 member 5 SLC12A5 0.0085
663 Solute carrier family 12 member 4 SLC12A4 0.0085
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
6043 Putative G-protein coupled receptor 44 GPR44 0.0083
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0083
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0083
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0083
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0083
1008 CTP synthase 1 CTPS 0.0083
3989 Glutaminyl-tRNA synthetase QARS 0.0083
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0083
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0083
3947 Xanthine dehydrogenase/oxidase XDH 0.0082
705 Glutamate receptor 1 GRIA1 0.0081
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.008
310 Solute carrier family 12 member 2 SLC12A2 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0079
3811 Cytochrome P450 19A1 CYP19A1 0.0079
4217 Telomerase reverse transcriptase TERT 0.0078
413 Amidophosphoribosyltransferase PPAT 0.0078
2515 Amidophosphoribosyltransferase purF 0.0078
3714 Amidophosphoribosyltransferase purF 0.0078
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0078
136 Estrogen receptor ESR1 0.0078
146 Androgen receptor AR 0.0078
494 Caspase-1 CASP1 0.0075
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0075
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0075
2795 Methionine aminopeptidase 2 METAP2 0.0075
831 D(2) dopamine receptor DRD2 0.0074
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0073
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0073
1507 Cytochrome c CYCS 0.0072
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
263 Neutral amino acid transporter B(0) SLC1A5 0.007
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.007
24 Thymidylate synthase TMP1 0.007
359 Thymidylate synthase TYMS 0.007
2626 Thymidylate synthase thyA 0.007
2729 Thymidylate synthase thyA 0.007
5352 Thymidylate synthase THYA 0.007
2981 Phospholipase A2, membrane associated PLA2G2A 0.0067
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0067
594 Thyroxine-binding globulin SERPINA7 0.0066
36 Insulin receptor INSR 0.0066
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0066
6 Coagulation factor XIII A chain F13A1 0.0066
6137 Multidrug resistance-associated protein 6 ABCC6 0.0066
2021 Thrombomodulin THBD 0.0065
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0065
3685 Catabolite gene activator crp 0.0065
4655 Adenylate cyclase cyaC 0.0064
4759 Adenylate cyclase cyaB2 0.0064
314 System N amino acid transporter 1 SLC38A3 0.0064
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0063
537 ATP synthase delta chain, mitochondrial ATP5D 0.0063
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0063
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0063
2077 Caspase-3 CASP3 0.0063
3932 Glutathione S-transferase A2 GSTA2 0.0063
6131 Carbonic anhydrase 14 CA14 0.0062
758 Thyroid hormone receptor alpha THRA 0.0061
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0061
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0061
1898 Cytochrome P450 1B1 CYP1B1 0.006
293 Gamma-glutamyl hydrolase GGH 0.006
482 Glycine receptor subunit alpha-1 GLRA1 0.006
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0059
6122 Carbonic anhydrase 3 CA3 0.0058
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0058
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0056
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0056
3007 Carbonic anhydrase 12 CA12 0.0055
4205 Carbonic anhydrase 9 CA9 0.0055
4760 Mll3241 protein mll3241 0.0055
346 Thyroid hormone receptor beta-1 THRB 0.0055
6218 Pannexin-1 PANX1 0.0054
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0054
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0054
320 5-hydroxytryptamine 1A receptor HTR1A 0.0054
1650 Heme carrier protein 1 SLC46A1 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0051
492 Histamine H1 receptor HRH1 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.005
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
5818 Folate receptor alpha FOLR1 0.0048
6042 Prostaglandin reductase 2 PTGR2 0.0048
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0047
2183 Fatty acid-binding protein, adipocyte FABP4 0.0047
70 Type-1 angiotensin II receptor AGTR1 0.0047
3382 Glycolipid transfer protein GLTP 0.0046
459 Retinoic acid receptor RXR-alpha RXRA 0.0046
33 Cystine/glutamate transporter SLC7A11 0.0045
1792 Tissue-type plasminogen activator PLAT 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0044
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
273 Apoptosis regulator Bcl-2 BCL2 0.0043
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0043
817 DNA topoisomerase 2-alpha TOP2A 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0042
844 Epidermal growth factor receptor EGFR 0.0041
408 Riboflavin kinase RFK 0.0041
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0039
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0037
1313 Lactoylglutathione lyase GLO1 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0037
1714 Mitogen-activated protein kinase 3 MAPK3 0.0037
869 Estrogen receptor beta ESR2 0.0037
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0035
997 Protein kinase C beta type PRKCB 0.0035
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0035
380 Cytochrome P450 17A1 CYP17A1 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0035
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0035
489 Monocarboxylate transporter 2 SLC16A7 0.0035
6014 Cytochrome P450 2A13 CYP2A13 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0033
634 Squalene monooxygenase SQLE 0.0033
7196 Squalene monooxygenase ERG1 0.0033
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0033
199 Monocarboxylate transporter 8 SLC16A2 0.0033
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0032
6677 Myelin P2 protein PMP2 0.0032
3941 Amine oxidase [flavin-containing] A MAOA 0.0032
6102 Arylamine N-acetyltransferase 2 NAT2 0.0032
2408 Tyrosine-protein kinase SYK SYK 0.0032
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0032
595 Fibrinogen alpha chain FGA 0.0032
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0031
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0031
1050 Bile salt sulfotransferase SULT2A1 0.003
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.003
4026 Aspartyl aminopeptidase DNPEP 0.003
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.003
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.003
1047 Excitatory amino acid transporter 2 SLC1A2 0.003
926 Metabotropic glutamate receptor 7 GRM7 0.003
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.003
4016 Excitatory amino acid transporter 5 SLC1A7 0.003
4019 Excitatory amino acid transporter 4 SLC1A6 0.003
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.003
1912 Excitatory amino acid transporter 1 SLC1A3 0.003
927 Metabotropic glutamate receptor 8 GRM8 0.003
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.003
4017 5-oxoprolinase OPLAH 0.003
922 Glutamate receptor 4 GRIA4 0.003
925 Metabotropic glutamate receptor 4 GRM4 0.003
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.003
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.003
4020 Glutamyl aminopeptidase ENPEP 0.003
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.003
4018 Glutamate receptor delta-2 subunit GRID2 0.003
4027 Glutamate receptor delta-1 subunit GRID1 0.003
664 Glutamate decarboxylase 2 GAD2 0.003
3890 Glutamate decarboxylase 2 GAD2 0.003
654 Flavin reductase BLVRB 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
6031 Cytochrome P450 3A43 CYP3A43 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
6501 Fatty acid-binding protein, liver FABP1 0.0029
3587 Gastrotropin FABP6 0.0028
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0028
163 D(1B) dopamine receptor DRD5 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
5126 Arginase rocF 0.0027
1025 Aquaporin-1 AQP1 0.0027
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0027
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0027
122 P2Y purinoceptor 12 P2RY12 0.0026
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0026
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
432 D(4) dopamine receptor DRD4 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0026
822 Aldose reductase AKR1B1 0.0026
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0026
365 Dihydrofolate reductase DHFR 0.0026
2381 Dihydrofolate reductase DFR1 0.0026
2833 Dihydrofolate reductase Not Available 0.0026
2931 Dihydrofolate reductase folA 0.0026
3544 Dihydrofolate reductase folA 0.0026
3682 Dihydrofolate reductase folA 0.0026
6642 Dihydrofolate reductase folA 0.0026
6756 Dihydrofolate reductase dfrA 0.0026
4773 Deoxycytidine kinase DCK 0.0026
638 D(3) dopamine receptor DRD3 0.0025
740 Argininosuccinate synthase ASS1 0.0025
865 Argininosuccinate synthase ASS1 0.0025
2680 Argininosuccinate synthase argG 0.0025
3194 Argininosuccinate synthase argG 0.0025
625 Glutamate carboxypeptidase 2 FOLH1 0.0025
665 Phosphoserine aminotransferase PSAT1 0.0025
4652 Phosphoserine aminotransferase serC 0.0025
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0025
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0025
420 Glutamate decarboxylase 1 GAD1 0.0025
3900 Glutamate decarboxylase 1 GAD1 0.0025
824 Sodium-dependent serotonin transporter SLC6A4 0.0025
847 Mu-type opioid receptor OPRM1 0.0025
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
465 Calmodulin CALM1 0.0024
811 Translocator protein TSPO 0.0024
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0024
6231 Pepsin A PGA3 0.0024
916 Metabotropic glutamate receptor 1 GRM1 0.0024
1671 Excitatory amino acid transporter 3 SLC1A1 0.0023
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0023
3877 Growth-inhibiting protein 18 GIG18 0.0023
923 Glutamate receptor 3 GRIA3 0.0023
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0023
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0023
1039 Histone deacetylase 9 HDAC9 0.0023
696 Kappa-type opioid receptor OPRK1 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
1525 Heparin-binding growth factor 2 FGF2 0.0022
6103 Arylamine N-acetyltransferase 1 NAT1 0.0022
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0022
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0022
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0022
763 Tyrosine aminotransferase TAT 0.0022
5493 Tyrosine aminotransferase Not Available 0.0022
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0022
426 Aspartate aminotransferase, mitochondrial GOT2 0.0022
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
735 Alanine aminotransferase 1 GPT 0.0022
5428 Replication protein repA 0.0022
3904 Alanine aminotransferase 2 GPT2 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
6168 Solute carrier family 22 member 16 SLC22A16 0.0021
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0021
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0021
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0021
4210 Toll-like receptor 4 TLR4 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.002
768 FK506-binding protein 1A FKBP1A 0.002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.002
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.002
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.002
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.002
1992 Vitamin D-binding protein GC 0.002
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
1517 Beta-3 adrenergic receptor ADRB3 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5787 Angiopoietin-1 receptor TEK 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
5934 Cytochrome P450 26A1 CYP26A1 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
1291 cAMP response element-binding protein CREB1 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
229 Retinoic acid receptor beta RARB 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
780 Retinoic acid receptor RXR-gamma RXRG 0.0017
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0016
2207 Rhodopsin RHO 0.0016
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0016
88 Retinoic acid receptor RXR-beta RXRB 0.0016
162 Retinoic acid receptor gamma-1 RARG 0.0015
614 Progesterone receptor PGR 0.0015
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0015
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0015
871 Glucocorticoid receptor NR3C1 0.0014
2693 Heat-labile enterotoxin B chain eltB 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
789 Alpha-1D adrenergic receptor ADRA1D 0.0014
6645 D-amino-acid oxidase DAO 0.0014
921 Glutamate receptor 2 GRIA2 0.0014
467 Delta-type opioid receptor OPRD1 0.0013
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0013
1656 CYP2B protein CYP2B 0.0013
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
283 SEC14-like protein 2 SEC14L2 0.0013
1618 High affinity nerve growth factor receptor NTRK1 0.0013
6459 Glycodelin PAEP 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
751 Potassium channel subfamily K member 6 KCNK6 0.0013
6432 Transporter snf 0.0013
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0012
4226 Uridine phosphorylase 2 UPP2 0.0012
702 UMP-CMP kinase CMPK1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0012
590 5-hydroxytryptamine 2C receptor HTR2C 0.0012
4225 Uridine phosphorylase 1 UPP1 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.001
51 Muscarinic acetylcholine receptor M3 CHRM3 0.001
617 Muscarinic acetylcholine receptor M2 CHRM2 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.001
103 Muscarinic acetylcholine receptor M1 CHRM1 0.001
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.001
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.001
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.001
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.001
6493 Cytochrome c oxidase subunit 6C COX6C 0.001
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.001
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.001
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.001
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.001
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.001
6559 Cytochrome c oxidase subunit 2 ctaC 0.001
6669 Cytochrome c oxidase subunit 2 ctaC 0.001
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.001
371 Cytochrome c oxidase subunit 1 MT-CO1 0.001
6558 Cytochrome c oxidase subunit 1 ctaD 0.001
904 Glutathione S-transferase P GSTP1 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
1353 DNA topoisomerase 1 TOP1 0.0009
3552 DNA topoisomerase 1 topA 0.0009
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0009
436 5-hydroxytryptamine 2B receptor HTR2B 0.0009
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
1864 RET proto-oncogene RET 0.0009
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0009
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0009
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0009
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0009
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0009
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0009
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0009
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0009
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0009
2540 Choloylglycine hydrolase cbh 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
378 Alpha-2C adrenergic receptor ADRA2C 0.0008
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0008
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
629 Alpha-2B adrenergic receptor ADRA2B 0.0008
3937 Fatty-acid amide hydrolase FAAH 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0008
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0008
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0008
731 HIV-1 protease HIV-1 protease 0.0008
3809 Estrogen-related receptor gamma ESRRG 0.0007
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0007
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0007
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
228 Beta platelet-derived growth factor receptor PDGFRB 0.0007
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
504 Mast/stem cell growth factor receptor KIT 0.0006
517 Alcohol dehydrogenase 1C ADH1C 0.0006
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0006
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
193 Beta-1 adrenergic receptor ADRB1 0.0005
5961 Insulin INS 0.0005
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
528 5-hydroxytryptamine 1E receptor HTR1E 0.0004
1256 5-hydroxytryptamine 6 receptor HTR6 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
716 5-hydroxytryptamine 7 receptor HTR7 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
341 5-hydroxytryptamine 3 receptor HTR3A 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
725 5-hydroxytryptamine 1D receptor HTR1D 0.0003
885 5-hydroxytryptamine 1B receptor HTR1B 0.0003
4943 Cytochrome c6 petJ 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4942 Diheme cytochrome c napB napB 0.0003
5000 HemO hemO 0.0003
4916 Cyanoglobin glbN 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4984 Neuroglobin NGB 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4961 Hemophore HasA hasA 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4910 Cytoglobin CYGB 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4909 CooA protein cooA 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4952 Catalase/peroxidase katA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
6228 Nuclear receptor coactivator 1 NCOA1 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
4920 Peroxidase/catalase katG 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
4990 PpcA ppcA 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
518 Peroxidase/catalase T katG 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
605 Fumarate reductase flavoprotein subunit frdA 0.0002
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0002
3673 Fumarate reductase flavoprotein subunit fccA 0.0002
4912 Fumarate reductase flavoprotein subunit ifcA 0.0002
6549 Fumarate reductase flavoprotein subunit frdA 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
260 Cytochrome P450 51 ERG11 0.0002
761 Cytochrome P450 51 ERG11 0.0002
3163 Cytochrome P450 51 cyp51 0.0002
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
76 Nitric-oxide synthase, brain NOS1 0.0001
7 Nitric oxide synthase, inducible NOS2 0.0001
291 Nitric-oxide synthase, endothelial NOS3 0.0001
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