DT-Web

DB00145 - Glycine


Identification
Name Glycine
Accession Number DB00145 (NUTR00028)
Type small molecule
Description A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 75.0666
Groups approved
Monoisotopic Weight 75.032028409
Pharmacology
Indication Supplemental glycine may have antispastic activity. Very early findings suggest it may also have antipsychotic activity as well as antioxidant and anti-inflammatory activities.
Mechanism of action In the CNS, there exist strychnine-sensitive glycine binding sites as well as strychnine-insensitive glycine binding sites. The strychnine-insensitive glycine-binding site is located on the NMDA receptor complex. The strychnine-sensitive glycine receptor complex is comprised of a chloride channel and is a member of the ligand-gated ion channel superfamily. The putative antispastic activity of supplemental glycine could be mediated by glycine's binding to strychnine-sensitive binding sites in the spinal cord. This would result in increased chloride conductance and consequent enhancement of inhibitory neurotransmission. The ability of glycine to potentiate NMDA receptor-mediated neurotransmission raised the possibility of its use in the management of neuroleptic-resistant negative symptoms in schizophrenia.
Animal studies indicate that supplemental glycine protects against endotoxin-induced lethality, hypoxia-reperfusion injury after liver transplantation, and D-galactosamine-mediated liver injury. Neutrophils are thought to participate in these pathologic processes via invasion of tissue and releasing such reactive oxygen species as superoxide. In vitro studies have shown that neutrophils contain a glycine-gated chloride channel that can attenuate increases in intracellular calcium and diminsh neutrophil oxidant production. This research is ealy-stage, but suggests that supplementary glycine may turn out to be useful in processes where neutrophil infiltration contributes to toxicity, such as ARDS.
Absorption Absorbed from the small intestine via an active transport mechanism.
Protein binding Not Available
Biotransformation Hepatic
Route of elimination Not Available
Toxicity ORL-RAT LD50 7930 mg/kg, SCU-RAT LD50 5200 mg/kg, IVN-RAT LD50 2600 mg/kg, ORL-MUS LD50 4920 mg/kg; Doses of 1 gram daily are very well tolerated. Mild gastrointestinal symptoms are infrequently noted. In one study doses of 90 grams daily were also well tole.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Name 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Gene Name GCAT
Pharmacological action unknown
Actions Not Available
References
  • Bashir Q, Rashid N, Akhtar M: Mechanism and substrate stereochemistry of 2-amino-3-oxobutyrate CoA ligase: implications for 5-aminolevulinate synthase and related enzymes. Chem Commun (Camb). 2006 Dec 28;(48):5065-7. Epub 2006 Oct 13. - Pubmed
DTHybrid score 0.6989
5-aminolevulinate synthase, nonspecific, mitochondrial
Name 5-aminolevulinate synthase, nonspecific, mitochondrial
Gene Name ALAS1
Pharmacological action unknown
Actions Not Available
References
  • Turbeville TD, Zhang J, Hunter GA, Ferreira GC: Histidine 282 in 5-aminolevulinate synthase affects substrate binding and catalysis. Biochemistry. 2007 May 22;46(20):5972-81. Epub 2007 May 1. - Pubmed
  • He XM, Zhou J, Cheng Y, Fan J: [Purification and production of the extracellular 5-aminolevulinate from recombiniant Escherichia coli expressing yeast ALAS] Sheng Wu Gong Cheng Xue Bao. 2007 May;23(3):520-4. - Pubmed
DTHybrid score 0.7006
5-aminolevulinate synthase, erythroid-specific, mitochondrial
Name 5-aminolevulinate synthase, erythroid-specific, mitochondrial
Gene Name ALAS2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Hungerer C, Troup B, Romling U, Jahn D: Regulation of the hemA gene during 5-aminolevulinic acid formation in Pseudomonas aeruginosa. J Bacteriol. 1995 Mar;177(6):1435-43. - Pubmed
  • Shoolingin-Jordan PM, Al-Daihan S, Alexeev D, Baxter RL, Bottomley SS, Kahari ID, Roy I, Sarwar M, Sawyer L, Wang SF: 5-Aminolevulinic acid synthase: mechanism, mutations and medicine. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):361-6. - Pubmed
  • Munakata H, Yamagami T, Nagai T, Yamamoto M, Hayashi N: Purification and structure of rat erythroid-specific delta-aminolevulinate synthase. J Biochem (Tokyo). 1993 Jul;114(1):103-11. - Pubmed
DTHybrid score 0.8475
Glycine cleavage system H protein, mitochondrial
Name Glycine cleavage system H protein, mitochondrial
Gene Name GCSH
Pharmacological action unknown
Actions Not Available
References
  • Kanno J, Hutchin T, Kamada F, Narisawa A, Aoki Y, Matsubara Y, Kure S: Genomic deletion within GLDC is a major cause of non-ketotic hyperglycinaemia. J Med Genet. 2007 Mar;44(3):e69. - Pubmed
DTHybrid score 1.2976
Glycyl-tRNA synthetase
Name Glycyl-tRNA synthetase
Gene Name GARS
Pharmacological action unknown
Actions Not Available
References
  • Okamoto K, Kuno A, Hasegawa T: Recognition sites of glycine tRNA for glycyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1. Nucleic Acids Symp Ser (Oxf). 2005;(49):299-300. - Pubmed
  • Tsang SW, Vinters HV, Cummings JL, Wong PT, Chen CP, Lai MK: Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease. Neurobiol Aging. 2007 Apr 10;. - Pubmed
  • Scherer SS: Inherited neuropathies: new genes don't fit old models. Neuron. 2006 Sep 21;51(6):672-4. - Pubmed
  • Cader MZ, Ren J, James PA, Bird LE, Talbot K, Stammers DK: Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy. FEBS Lett. 2007 Jun 26;581(16):2959-64. Epub 2007 May 29. - Pubmed
  • Antonellis A, Lee-Lin SQ, Wasterlain A, Leo P, Quezado M, Goldfarb LG, Myung K, Burgess S, Fischbeck KH, Green ED: Functional analyses of glycyl-tRNA synthetase mutations suggest a key role for tRNA-charging enzymes in peripheral axons. J Neurosci. 2006 Oct 11;26(41):10397-406. - Pubmed
DTHybrid score 0.8462
Glutamate [NMDA] receptor subunit epsilon-1
Name Glutamate [NMDA] receptor subunit epsilon-1
Gene Name GRIN2A
Pharmacological action unknown
Actions antagonist
References
  • Liu Y, Wong TP, Aarts M, Rooyakkers A, Liu L, Lai TW, Wu DC, Lu J, Tymianski M, Craig AM, Wang YT: NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci. 2007 Mar 14;27(11):2846-57. - Pubmed
  • Domingues A, Almeida S, da Cruz e Silva EF, Oliveira CR, Rego AC: Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunits. Neurochem Int. 2007 May;50(6):872-80. Epub 2007 Mar 7. - Pubmed
  • Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI 2nd, Sonner JM: Ammonia has anesthetic properties. Anesth Analg. 2007 Jun;104(6):1430-3, table of contents. - Pubmed
  • Milutinovic PS, Yang L, Cantor RS, Eger EI 2nd, Sonner JM: Anesthetic-like modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased neurotransmitters. Anesth Analg. 2007 Aug;105(2):386-92. - Pubmed
  • Gabra BH, Kessler FK, Ritter JK, Dewey WL, Smith FL: Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia. J Pharmacol Exp Ther. 2007 Jul;322(1):186-94. Epub 2007 Apr 3. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6428
Bile acid CoA:amino acid N-acyltransferase
Name Bile acid CoA:amino acid N-acyltransferase
Gene Name BAAT
Pharmacological action unknown
Actions Not Available
References
  • Styles NA, Falany JL, Barnes S, Falany CN: Quantification and regulation of the subcellular distribution of bile acid coenzyme A:amino acid N-acyltransferase activity in rat liver. J Lipid Res. 2007 Jun;48(6):1305-15. Epub 2007 Mar 22. - Pubmed
  • Visser WF, van Roermund CW, Ijlst L, Waterham HR, Wanders RJ: Demonstration of bile acid transport across the mammalian peroxisomal membrane. Biochem Biophys Res Commun. 2007 Jun 1;357(2):335-40. Epub 2007 Mar 26. - Pubmed
  • Pellicoro A, van den Heuvel FA, Geuken M, Moshage H, Jansen PL, Faber KN: Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport. Hepatology. 2007 Feb;45(2):340-8. - Pubmed
  • Nakamura K, Morrison SF: Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R127-36. Epub 2006 Aug 24. - Pubmed
DTHybrid score 0.8464
N-arachidonyl glycine receptor
Name N-arachidonyl glycine receptor
Gene Name GPR18
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8465
Glutathione synthetase
Name Glutathione synthetase
Gene Name GSS
Pharmacological action unknown
Actions Not Available
References
  • Herrera K, Cahoon RE, Kumaran S, Jez J: Reaction mechanism of glutathione synthetase from Arabidopsis thaliana: site-directed mutagenesis of active site residues. J Biol Chem. 2007 Jun 8;282(23):17157-65. Epub 2007 Apr 22. - Pubmed
  • Ducruix C, Junot C, Fievet JB, Villiers F, Ezan E, Bourguignon J: New insights into the regulation of phytochelatin biosynthesis in A. thaliana cells from metabolite profiling analyses. Biochimie. 2006 Nov;88(11):1733-42. Epub 2006 Sep 7. - Pubmed
  • Ristoff E, Larsson A: Inborn errors in the metabolism of glutathione. Orphanet J Rare Dis. 2007 Mar 30;2:16. - Pubmed
  • Pai CH, Chiang BY, Ko TP, Chou CC, Chong CM, Yen FJ, Chen S, Coward JK, Wang AH, Lin CH: Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase. EMBO J. 2006 Dec 13;25(24):5970-82. Epub 2006 Nov 23. - Pubmed
  • Janaky R, Dohovics R, Saransaari P, Oja SS: Modulation of [3H]dopamine release by glutathione in mouse striatal slices. Neurochem Res. 2007 Aug;32(8):1357-64. Epub 2007 Mar 31. - Pubmed
DTHybrid score 0.8368
Glutamate [NMDA] receptor subunit epsilon-3
Name Glutamate [NMDA] receptor subunit epsilon-3
Gene Name GRIN2C
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Widdowson PS, Gyte AJ, Upton R, Wyatt I: Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Brain Res. 1996 Nov 4;738(2):236-42. - Pubmed
  • Al-Ghoul WM, Meeker RB, Greenwood RS: Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in vasopressin and oxytocin neuroendocrine cells. Brain Res Mol Brain Res. 1997 Mar;44(2):262-72. - Pubmed
  • Malayev A, Gibbs TT, Farb DH: Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids. Br J Pharmacol. 2002 Feb;135(4):901-9. - Pubmed
DTHybrid score 0.6734
Serine hydroxymethyltransferase 2
Name Serine hydroxymethyltransferase 2
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Bouwman RA, Musters RJ, van Beek-Harmsen BJ, de Lange JJ, Lamberts RR, Loer SA, Boer C: Sevoflurane-induced cardioprotection depends on PKC-{alpha} activation via production of reactive oxygen species. Br J Anaesth. 2007 Sep 27;. - Pubmed
  • Chang WN, Tsai JN, Chen BH, Huang HS, Fu TF: Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin-Characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases. Drug Metab Dispos. 2007 Jul 30;. - Pubmed
  • Kon K, Ikejima K, Okumura K, Aoyama T, Arai K, Takei Y, Lemasters JJ, Sato N: Role of apoptosis in acetaminophen hepatotoxicity. J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1:S49-52. - Pubmed
DTHybrid score 0.7733
SHMT2 protein
Name SHMT2 protein
Gene Name SHMT2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7684
Hypothetical protein DKFZp686P09201
Name Hypothetical protein DKFZp686P09201
Gene Name DKFZp686P09201
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7731
Glycine N-acyltransferase
Name Glycine N-acyltransferase
Gene Name GLYAT
Pharmacological action unknown
Actions Not Available
References
  • Narasipura SD, Ren P, Dyavaiah M, Auger I, Chaturvedi V, Chaturvedi S: An efficient method for homologous gene reconstitution in Cryptococcus gattii using URA5 auxotrophic marker. Mycopathologia. 2006 Dec;162(6):401-9. - Pubmed
  • Zhou CX, Gao Y: Frequent genetic alterations and reduced expression of the Axin1 gene in oral squamous cell carcinoma: involvement in tumor progression and metastasis. Oncol Rep. 2007 Jan;17(1):73-9. - Pubmed
DTHybrid score 0.847
Proton-coupled amino acid transporter 1
Name Proton-coupled amino acid transporter 1
Gene Name SLC36A1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Bermingham JR Jr, Pennington J: Organization and expression of the SLC36 cluster of amino acid transporter genes. Mamm Genome. 2004 Feb;15(2):114-25. - Pubmed
  • Broer A, Cavanaugh JA, Rasko JE, Broer S: The molecular basis of neutral aminoacidurias. Pflugers Arch. 2006 Jan;451(4):511-7. Epub 2005 Jul 29. - Pubmed
  • Metzner L, Kalbitz J, Brandsch M: Transport of pharmacologically active proline derivatives by the human proton-coupled amino acid transporter hPAT1. J Pharmacol Exp Ther. 2004 Apr;309(1):28-35. Epub 2004 Jan 12. - Pubmed
DTHybrid score 1.3414
SHMT2 protein
Name SHMT2 protein
Gene Name SHMT2
Pharmacological action unknown
Actions Not Available
References
  • Vatsyayan R, Roy U: Molecular cloning and biochemical characterization of Leishmania donovani serine hydroxymethyltransferase. Protein Expr Purif. 2007 Apr;52(2):433-40. Epub 2006 Oct 26. - Pubmed
  • Rajinikanth M, Harding SA, Tsai CJ: The glycine decarboxylase complex multienzyme family in Populus. J Exp Bot. 2007;58(7):1761-70. Epub 2007 Mar 12. - Pubmed
  • Gagnon D, Foucher A, Girard I, Ouellette M: Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania. Mol Biochem Parasitol. 2006 Nov;150(1):63-71. Epub 2006 Jul 13. - Pubmed
  • Mukherjee M, Sievers SA, Brown MT, Johnson PJ: Identification and biochemical characterization of serine hydroxymethyl transferase in the hydrogenosome of Trichomonas vaginalis. Eukaryot Cell. 2006 Dec;5(12):2072-8. Epub 2006 Sep 15. - Pubmed
  • Chang WN, Tsai JN, Chen BH, Huang HS, Fu TF: Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin-Characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases. Drug Metab Dispos. 2007 Jul 30;. - Pubmed
DTHybrid score 0.7684
Glycine N-acyltransferase-like protein 2
Name Glycine N-acyltransferase-like protein 2
Gene Name GLYATL2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8472
Glycine N-acyltransferase-like protein 1
Name Glycine N-acyltransferase-like protein 1
Gene Name GLYATL1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8473
Alanine--glyoxylate aminotransferase 2, mitochondrial
Name Alanine--glyoxylate aminotransferase 2, mitochondrial
Gene Name AGXT2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Baker PR, Cramer SD, Kennedy M, Assimos DG, Holmes RP: Glycolate and glyoxylate metabolism in HepG2 cells. Am J Physiol Cell Physiol. 2004 Nov;287(5):C1359-65. Epub 2004 Jul 7. - Pubmed
  • Takada Y, Mori T, Noguchi T: The effect of vitamin B6 deficiency on alanine: glyoxylate aminotransferase isoenzymes in rat liver. Arch Biochem Biophys. 1984 Feb 15;229(1):1-6. - Pubmed
DTHybrid score 0.6891
Vesicular inhibitory amino acid transporter
Name Vesicular inhibitory amino acid transporter
Gene Name SLC32A1
Pharmacological action unknown
Actions Not Available
References
  • Fujii M, Arata A, Kanbara-Kume N, Saito K, Yanagawa Y, Obata K: Respiratory activity in brainstem of fetal mice lacking glutamate decarboxylase 65/67 and vesicular GABA transporter. Neuroscience. 2007 May 25;146(3):1044-52. Epub 2007 Apr 5. - Pubmed
  • Aubrey KR, Rossi FM, Ruivo R, Alboni S, Bellenchi GC, Le Goff A, Gasnier B, Supplisson S: The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype. J Neurosci. 2007 Jun 6;27(23):6273-81. - Pubmed
  • Uchigashima M, Fukaya M, Watanabe M, Kamiya H: Evidence against GABA release from glutamatergic mossy fiber terminals in the developing hippocampus. J Neurosci. 2007 Jul 25;27(30):8088-100. - Pubmed
DTHybrid score 0.8464
Peroxisomal sarcosine oxidase
Name Peroxisomal sarcosine oxidase
Gene Name PIPOX
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8465
Sodium- and chloride-dependent glycine transporter 2
Name Sodium- and chloride-dependent glycine transporter 2
Gene Name SLC6A5
Pharmacological action unknown
Actions Not Available
References
  • Eulenburg V, Becker K, Gomeza J, Schmitt B, Becker CM, Betz H: Mutations within the human GLYT2 (SLC6A5) gene associated with hyperekplexia. Biochem Biophys Res Commun. 2006 Sep 22;348(2):400-5. Epub 2006 Jul 26. - Pubmed
DTHybrid score 0.8465
Glutamate [NMDA] receptor subunit 3B
Name Glutamate [NMDA] receptor subunit 3B
Gene Name GRIN3B
Pharmacological action unknown
Actions Not Available
References
  • Smothers CT, Woodward JJ: Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits. J Pharmacol Exp Ther. 2007 Aug;322(2):739-48. Epub 2007 May 14. - Pubmed
DTHybrid score 0.6312
Glycine dehydrogenase [decarboxylating], mitochondrial
Name Glycine dehydrogenase [decarboxylating], mitochondrial
Gene Name GLDC
Pharmacological action unknown
Actions Not Available
References
  • Mukherjee M, Brown MT, McArthur AG, Johnson PJ: Proteins of the glycine decarboxylase complex in the hydrogenosome of Trichomonas vaginalis. Eukaryot Cell. 2006 Dec;5(12):2062-71. - Pubmed
  • Kanno J, Hutchin T, Kamada F, Narisawa A, Aoki Y, Matsubara Y, Kure S: Genomic deletion within GLDC is a major cause of non-ketotic hyperglycinaemia. J Med Genet. 2007 Mar;44(3):e69. - Pubmed
  • Engel N, van den Daele K, Kolukisaoglu U, Morgenthal K, Weckwerth W, Parnik T, Keerberg O, Bauwe H: Deletion of glycine decarboxylase in Arabidopsis is lethal under nonphotorespiratory conditions. Plant Physiol. 2007 Jul;144(3):1328-35. Epub 2007 May 11. - Pubmed
DTHybrid score 0.6984
Sodium- and chloride-dependent glycine transporter 1
Name Sodium- and chloride-dependent glycine transporter 1
Gene Name SLC6A9
Pharmacological action unknown
Actions Not Available
References
  • Wiles AL, Pearlman RJ, Rosvall M, Aubrey KR, Vandenberg RJ: N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. J Neurochem. 2006 Nov;99(3):781-6. Epub 2006 Aug 8. - Pubmed
  • Lindsley CW, Wolkenberg SE, Kinney GG: Progress in the preparation and testing of glycine transporter type-1 (GlyT1) inhibitors. Curr Top Med Chem. 2006;6(17):1883-96. - Pubmed
  • Igartua I, Solis JM, Bustamante J: Glycine-induced long-term synaptic potentiation is mediated by the glycine transporter GLYT1. Neuropharmacology. 2007 Jun;52(8):1586-95. Epub 2007 Mar 14. - Pubmed
  • Sur C, Kinney GG: Glycine transporter 1 inhibitors and modulation of NMDA receptor-mediated excitatory neurotransmission. Curr Drug Targets. 2007 May;8(5):643-9. - Pubmed
  • Raiteri L, Stigliani S, Usai C, Diaspro A, Paluzzi S, Milanese M, Raiteri M, Bonanno G: Functional expression of release-regulating glycine transporters GLYT1 on GABAergic neurons and GLYT2 on astrocytes in mouse spinal cord. Neurochem Int. 2007 May 16;. - Pubmed
DTHybrid score 0.8465
Glycine receptor subunit alpha-1
Name Glycine receptor subunit alpha-1
Gene Name GLRA1
Pharmacological action unknown
Actions Not Available
References
  • Heinze L, Harvey RJ, Haverkamp S, Wassle H: Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit. J Comp Neurol. 2007 Feb 1;500(4):693-707. - Pubmed
  • Eulenburg V, Becker K, Gomeza J, Schmitt B, Becker CM, Betz H: Mutations within the human GLYT2 (SLC6A5) gene associated with hyperekplexia. Biochem Biophys Res Commun. 2006 Sep 22;348(2):400-5. Epub 2006 Jul 26. - Pubmed
DTHybrid score 0.7835
Serine--pyruvate aminotransferase
Name Serine--pyruvate aminotransferase
Gene Name AGXT
Pharmacological action unknown
Actions Not Available
References
  • Ricoult C, Echeverria LO, Cliquet JB, Limami AM: Characterization of alanine aminotransferase (AlaAT) multigene family and hypoxic response in young seedlings of the model legume Medicago truncatula. J Exp Bot. 2006;57(12):3079-89. Epub 2006 Aug 9. - Pubmed
  • Han Q, Robinson H, Gao YG, Vogelaar N, Wilson SR, Rizzi M, Li J: Crystal structures of Aedes aegypti alanine glyoxylate aminotransferase. J Biol Chem. 2006 Dec 1;281(48):37175-82. Epub 2006 Sep 21. - Pubmed
  • Lu TC, Ko YZ, Huang HW, Hung YC, Lin YC, Peng WH: Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice. J Ethnopharmacol. 2007 Aug 15;113(1):142-8. Epub 2007 May 31. - Pubmed
DTHybrid score 1.1123
Glycine receptor subunit beta
Name Glycine receptor subunit beta
Gene Name GLRB
Pharmacological action unknown
Actions Not Available
References
  • Eulenburg V, Becker K, Gomeza J, Schmitt B, Becker CM, Betz H: Mutations within the human GLYT2 (SLC6A5) gene associated with hyperekplexia. Biochem Biophys Res Commun. 2006 Sep 22;348(2):400-5. Epub 2006 Jul 26. - Pubmed
DTHybrid score 0.9473
Serine hydroxymethyltransferase, cytosolic
Name Serine hydroxymethyltransferase, cytosolic
Gene Name SHMT1
Pharmacological action unknown
Actions Not Available
References
  • Vatsyayan R, Roy U: Molecular cloning and biochemical characterization of Leishmania donovani serine hydroxymethyltransferase. Protein Expr Purif. 2007 Apr;52(2):433-40. Epub 2006 Oct 26. - Pubmed
  • Rajinikanth M, Harding SA, Tsai CJ: The glycine decarboxylase complex multienzyme family in Populus. J Exp Bot. 2007;58(7):1761-70. Epub 2007 Mar 12. - Pubmed
  • Chang WN, Tsai JN, Chen BH, Huang HS, Fu TF: Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin-Characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases. Drug Metab Dispos. 2007 Jul 30;. - Pubmed
  • Nijhout HF, Reed MC, Lam SL, Shane B, Gregory JF 3rd, Ulrich CM: In silico experimentation with a model of hepatic mitochondrial folate metabolism. Theor Biol Med Model. 2006 Dec 6;3:40. - Pubmed
  • Gagnon D, Foucher A, Girard I, Ouellette M: Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania. Mol Biochem Parasitol. 2006 Nov;150(1):63-71. Epub 2006 Jul 13. - Pubmed
DTHybrid score 1.0787
Glycine receptor subunit alpha-3
Name Glycine receptor subunit alpha-3
Gene Name GLRA3
Pharmacological action unknown
Actions Not Available
References
  • Heinze L, Harvey RJ, Haverkamp S, Wassle H: Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit. J Comp Neurol. 2007 Feb 1;500(4):693-707. - Pubmed
  • Majumdar S, Heinze L, Haverkamp S, Ivanova E, Wassle H: Glycine receptors of A-type ganglion cells of the mouse retina. Vis Neurosci. 2007 Jul-Aug;24(4):471-87. Epub 2007 May 29. - Pubmed
DTHybrid score 0.9242
Glycine receptor subunit alpha-2
Name Glycine receptor subunit alpha-2
Gene Name GLRA2
Pharmacological action unknown
Actions Not Available
References
  • Young-Pearse TL, Ivic L, Kriegstein AR, Cepko CL: Characterization of mice with targeted deletion of glycine receptor alpha 2. Mol Cell Biol. 2006 Aug;26(15):5728-34. - Pubmed
  • Qi Z, Stephens NR, Spalding EP: Calcium entry mediated by GLR3.3, an Arabidopsis glutamate receptor with a broad agonist profile. Plant Physiol. 2006 Nov;142(3):963-71. Epub 2006 Sep 29. - Pubmed
  • Majumdar S, Heinze L, Haverkamp S, Ivanova E, Wassle H: Glycine receptors of A-type ganglion cells of the mouse retina. Vis Neurosci. 2007 Jul-Aug;24(4):471-87. Epub 2007 May 29. - Pubmed
DTHybrid score 0.9041
Glycine N-methyltransferase
Name Glycine N-methyltransferase
Gene Name GNMT
Pharmacological action unknown
Actions Not Available
References
  • Soriano A, Castillo R, Christov C, Andres J, Moliner V, Tunon I: Catalysis in glycine N-methyltransferase: testing the electrostatic stabilization and compression hypothesis. Biochemistry. 2006 Dec 19;45(50):14917-25. - Pubmed
  • Luka Z, Pakhomova S, Loukachevitch LV, Egli M, Newcomer ME, Wagner C: 5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase. J Biol Chem. 2007 Feb 9;282(6):4069-75. Epub 2006 Dec 7. - Pubmed
  • Velichkova P, Himo F: Methyl transfer in glycine N-methyltransferase. A theoretical study. J Phys Chem B. 2005 Apr 28;109(16):8216-9. - Pubmed
DTHybrid score 0.5871
Serine hydroxymethyltransferase, mitochondrial
Name Serine hydroxymethyltransferase, mitochondrial
Gene Name SHMT2
Pharmacological action unknown
Actions Not Available
References
  • Gagnon D, Foucher A, Girard I, Ouellette M: Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania. Mol Biochem Parasitol. 2006 Nov;150(1):63-71. Epub 2006 Jul 13. - Pubmed
  • Vatsyayan R, Roy U: Molecular cloning and biochemical characterization of Leishmania donovani serine hydroxymethyltransferase. Protein Expr Purif. 2007 Apr;52(2):433-40. Epub 2006 Oct 26. - Pubmed
  • Rajinikanth M, Harding SA, Tsai CJ: The glycine decarboxylase complex multienzyme family in Populus. J Exp Bot. 2007;58(7):1761-70. Epub 2007 Mar 12. - Pubmed
DTHybrid score 0.7734
Glycine amidinotransferase, mitochondrial
Name Glycine amidinotransferase, mitochondrial
Gene Name GATM
Pharmacological action unknown
Actions Not Available
References
  • Wang L, Zhang Y, Shao M, Zhang H: Spatiotemporal expression of the creatine metabolism related genes agat, gamt and ct1 during zebrafish embryogenesis. Int J Dev Biol. 2007;51(3):247-53. - Pubmed
  • Dutta U, Cohenford MA, Guha M, Dain JA: Non-enzymatic interactions of glyoxylate with lysine, arginine, and glucosamine: a study of advanced non-enzymatic glycation like compounds. Bioorg Chem. 2007 Feb;35(1):11-24. Epub 2006 Sep 12. - Pubmed
DTHybrid score 1.2306

Transporters


Monocarboxylate transporter 10
Name Monocarboxylate transporter 10
Gene Name SLC16A10
Actions substrate,inhibitor
References
  • Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. - Pubmed
  • Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H: The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics. 2002 Jan;79(1):95-103. - Pubmed
DTHybrid score 0.7356

Predictions


Id Partner name Gene Name Score
5269 Glutathione synthetase gshB 0.8368
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.1925
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.1901
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.1818
914 Formimidoyltransferase-cyclodeaminase FTCD 0.1798
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.1761
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.1537
3763 5,10-methylenetetrahydrofolate reductase metF 0.1536
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.1536
5094 5,10-methylenetetrahydrofolate reductase metF 0.1536
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.1535
59 AMT protein AMT 0.1535
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.1534
336 Ornithine carbamoyltransferase, mitochondrial OTC 0.152
358 Cystathionine beta-synthase CBS 0.1502
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.149
3470 Hypothetical protein MG245 homolog MPN_348 0.1458
169 Cysteine desulfurase, mitochondrial NFS1 0.1422
3082 Aminomethyltransferase gcvT 0.1365
6839 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial PDK3 0.1356
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.132
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.1215
435 Kynureninase KYNU 0.1213
4654 Kynureninase kynU 0.1213
3904 Alanine aminotransferase 2 GPT2 0.1194
735 Alanine aminotransferase 1 GPT 0.1194
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.119
56 Delta-aminolevulinic acid dehydratase ALAD 0.1186
2356 Delta-aminolevulinic acid dehydratase hemB 0.1186
3613 Delta-aminolevulinic acid dehydratase hemB 0.1186
3674 Delta-aminolevulinic acid dehydratase hemB 0.1186
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.1176
13 Aminomethyltransferase, mitochondrial AMT 0.116
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.1112
449 Ornithine decarboxylase ODC1 0.1105
184 L-serine dehydratase SDS 0.105
491 Serine palmitoyltransferase 1 SPTLC1 0.105
431 Serine racemase SRR 0.105
727 Serine palmitoyltransferase 2 SPTLC2 0.1049
809 Methionine synthase MTR 0.1048
2935 Methionine synthase metH 0.1048
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0992
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0947
89 Cysteine sulfinic acid decarboxylase CSAD 0.09
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0895
3917 Methylenetetrahydrofolate reductase MTHFR 0.0893
6013 Cytochrome P450 2E1 CYP2E1 0.0871
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0862
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0845
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0843
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0841
3880 Serine hydroxymethyltransferase 1 Not Available 0.0839
763 Tyrosine aminotransferase TAT 0.0835
5493 Tyrosine aminotransferase Not Available 0.0835
3886 Migration-inducing protein 4 ALAS1 0.0834
534 Threonine synthase-like 1 THNSL1 0.0831
537 ATP synthase delta chain, mitochondrial ATP5D 0.0824
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0818
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0816
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0813
4823 L-allo-threonine aldolase TM_1744 0.0812
3883 Ornithine aminotransferase variant Not Available 0.0811
3887 Phosphorylase PYGB 0.081
306 Pyridoxal phosphate phosphatase PDXP 0.081
3911 Uncharacterized protein C20orf38 SPTLC3 0.081
3908 P-selectin cytoplasmic tail-associated protein pcap 0.081
3891 Putative L-Dopa decarboxylase DDC 0.081
3881 Selenocysteine lyase variant Not Available 0.081
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.081
3906 Serine dehydratase-like SDSL 0.081
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.081
3878 GAD1 protein GAD1 0.081
3893 DDC protein DDC 0.081
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.081
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.081
3875 Glycogen phosphorylase, brain form PYGB 0.081
3882 Brain glycogen phosphorylase variant Not Available 0.081
3894 KIAA0251 protein PDXDC1 0.0809
3905 Molybdenum cofactor sulfurase MOCOS 0.0809
3 Histidine decarboxylase HDC 0.0791
665 Phosphoserine aminotransferase PSAT1 0.0784
4652 Phosphoserine aminotransferase serC 0.0784
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0784
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0783
420 Glutamate decarboxylase 1 GAD1 0.0783
3900 Glutamate decarboxylase 1 GAD1 0.0783
532 Neutral amino acid transporter A SLC1A4 0.0782
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0782
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0782
6030 Cytochrome P450 2B6 CYP2B6 0.0778
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0773
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0756
472 Ornithine aminotransferase, mitochondrial OAT 0.0753
868 Cystathionine gamma-lyase CTH 0.0742
4551 Lantibiotic mersacidin mrsA 0.0738
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0736
3877 Growth-inhibiting protein 18 GIG18 0.0733
499 Arginine decarboxylase ADC 0.0712
705 Glutamate receptor 1 GRIA1 0.0711
4512 Cytochrome P450 3A4 CYP3A4 0.071
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0699
426 Aspartate aminotransferase, mitochondrial GOT2 0.0698
1649 Small inducible cytokine A2 CCL2 0.069
1278 Pro-epidermal growth factor EGF 0.0682
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0672
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0655
3193 Serine hydroxymethyltransferase glyA 0.0652
3342 Serine hydroxymethyltransferase glyA 0.0652
3913 Glutamic acid decarboxylase GAD65 0.065
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0599
6024 Cytochrome P450 1A1 CYP1A1 0.0594
279 Tyrosinase TYR 0.0592
864 Gag-Pol polyprotein gag-pol 0.059
2237 Gag-Pol polyprotein gag-pol 0.059
2326 Gag-Pol polyprotein gag-pol 0.059
2451 Gag-Pol polyprotein gag-pol 0.059
2901 Gag-Pol polyprotein gag-pol 0.059
3165 Gag-Pol polyprotein gag-pol 0.059
3722 Gag-Pol polyprotein gag-pol 0.059
6306 Gag-Pol polyprotein gag-pol 0.059
6624 Gag-Pol polyprotein gag-pol 0.059
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0585
330 Spermidine synthase SRM 0.0572
3038 Spermidine synthase speE 0.0572
587 Serum albumin ALB 0.0563
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0555
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0549
5469 Head decoration protein shp 0.0518
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0507
6016 Cytochrome P450 2C19 CYP2C19 0.0493
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0492
916 Metabotropic glutamate receptor 1 GRM1 0.0471
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.0448
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0446
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0435
1152 Glycogen phosphorylase, muscle form PYGM 0.0426
199 Monocarboxylate transporter 8 SLC16A2 0.0426
10 Glycogen phosphorylase, liver form PYGL 0.0416
1566 Corticoliberin CRH 0.0413
4096 Metabotropic glutamate receptor 3 GRM3 0.0401
1362 Metabotropic glutamate receptor 2 GRM2 0.04
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0384
2178 Metabotropic glutamate receptor 5 GRM5 0.0375
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0356
5718 Cytochrome P450 2A6 CYP2A6 0.0331
150 Cationic amino acid transporter 3 SLC7A3 0.033
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.033
58 Cationic amino acid transporter 4 SLC7A4 0.033
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0313
4757 Cytochrome P450 2C9 CYP2C9 0.0311
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0307
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0307
1268 Neuropeptide S receptor NPSR1 0.0307
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0307
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0307
218 Monocarboxylate transporter 5 SLC16A4 0.0304
397 Monocarboxylate transporter 3 SLC16A8 0.0304
195 Monocarboxylate transporter 7 SLC16A6 0.0304
429 Monocarboxylate transporter 6 SLC16A5 0.0303
4119 Cytochrome P450 2D6 CYP2D6 0.0297
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0289
2532 Pantoate--beta-alanine ligase panC 0.0285
3810 Catechol O-methyltransferase COMT 0.028
171 Cysteine dioxygenase CDO-1 0.0272
1314 Thiamine transporter 2 SLC19A3 0.0271
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0271
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0271
5492 Cystathionine gamma-synthase metB 0.027
5491 Methionine gamma-lyase mdeA 0.027
738 Monocarboxylate transporter 1 SLC16A1 0.0268
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0263
251 Alcohol dehydrogenase 1A ADH1A 0.026
6073 Potassium channel subfamily K member 9 KCNK9 0.0257
6072 Potassium channel subfamily K member 3 KCNK3 0.0257
3981 Ornithine decarboxylase antizyme 3 OAZ3 0.0254
410 Ornithine decarboxylase antizyme OAZ1 0.0254
224 Mitochondrial ornithine transporter 1 SLC25A15 0.0254
285 Mitochondrial ornithine transporter 2 SLC25A2 0.0254
3980 Ornithine decarboxylase antizyme 2 OAZ2 0.0254
834 Arginase-2, mitochondrial ARG2 0.0252
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.025
696 Kappa-type opioid receptor OPRK1 0.0248
862 Multidrug resistance-associated protein 1 ABCC1 0.0246
6645 D-amino-acid oxidase DAO 0.0245
500 Monocarboxylate transporter 4 SLC16A3 0.0241
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.024
489 Monocarboxylate transporter 2 SLC16A7 0.0237
5925 Neuropeptide Y NPY 0.0231
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.0229
314 System N amino acid transporter 1 SLC38A3 0.0229
52 Pyruvate kinase isozymes R/L PKLR 0.0228
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0227
444 Alcohol dehydrogenase 1B ADH1B 0.0226
771 Pyruvate carboxylase, mitochondrial PC 0.0219
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0218
626 Cysteine dioxygenase type 1 CDO1 0.0217
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0217
2758 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA 0.0215
468 Cytochrome P450 4A11 CYP4A11 0.0214
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.021
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0199
4069 Threonyl-tRNA synthetase, mitochondrial TARS2 0.0197
261 Threonyl-tRNA synthetase, cytoplasmic TARS 0.0197
246 Valyl-tRNA synthetase VARS 0.0196
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0193
517 Alcohol dehydrogenase 1C ADH1C 0.0192
33 Cystine/glutamate transporter SLC7A11 0.0182
2207 Rhodopsin RHO 0.0181
1588 Multidrug resistance protein 1 ABCB1 0.0181
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0168
2457 Bacillolysin nprS 0.016
2249 Aspartate aminotransferase aspC 0.0159
2671 Aspartate aminotransferase aspC 0.0159
5490 Aspartate aminotransferase Not Available 0.0159
315 Arginase-1 ARG1 0.0159
1998 Protein-L-isoaspartate(D-aspartate) O-methyltransferase PCMT1 0.0159
2551 Cobalt-precorrin-4 C(11)-methyltransferase cbiF 0.0159
4313 Probable tRNA/rRNA methyltransferase HI0766 trmL 0.0159
4316 Mycolic acid synthase pcaA 0.0159
4331 Chemotaxis protein methyltransferase cheR 0.0159
4323 Modification methylase HhaI hhaIM 0.0159
4314 Modification methylase PvuII pvuIIM 0.0159
3724 Protein methyltransferase hemK hemK 0.0159
4329 Uroporphyrinogen-III C-methyltransferase cobA 0.0159
4324 Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 SETD7 0.0159
4330 Hypothetical protein TTHA0667 TTHA0667 0.0159
4315 DNA adenine methylase DAM 0.0159
4309 S-adenosyl-L-methionine-dependent methyltransferase mraW rsmH 0.0159
4333 Protein-L-isoaspartate O-methyltransferase pcm 0.0159
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.0157
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0151
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0151
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0151
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0151
5 Glutaminase liver isoform, mitochondrial GLS2 0.0151
917 Glutaminase kidney isoform, mitochondrial GLS 0.0151
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0151
5261 Phosphoribosylformylglycinamidine synthase purL 0.0151
4200 Cytochrome P450 1A2 CYP1A2 0.015
676 Tyrosine 3-monooxygenase TH 0.0149
922 Glutamate receptor 4 GRIA4 0.0148
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0148
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0148
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0148
4018 Glutamate receptor delta-2 subunit GRID2 0.0148
4027 Glutamate receptor delta-1 subunit GRID1 0.0148
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0148
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0148
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0148
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0148
4026 Aspartyl aminopeptidase DNPEP 0.0148
4016 Excitatory amino acid transporter 5 SLC1A7 0.0148
664 Glutamate decarboxylase 2 GAD2 0.0148
3890 Glutamate decarboxylase 2 GAD2 0.0148
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0148
1912 Excitatory amino acid transporter 1 SLC1A3 0.0148
4019 Excitatory amino acid transporter 4 SLC1A6 0.0148
1047 Excitatory amino acid transporter 2 SLC1A2 0.0148
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0148
4020 Glutamyl aminopeptidase ENPEP 0.0148
925 Metabotropic glutamate receptor 4 GRM4 0.0148
927 Metabotropic glutamate receptor 8 GRM8 0.0148
926 Metabotropic glutamate receptor 7 GRM7 0.0148
4017 5-oxoprolinase OPLAH 0.0148
815 Histidyl-tRNA synthetase, cytoplasmic HARS 0.0147
96 Histidine ammonia-lyase HAL 0.0147
6257 Histidine ammonia-lyase Not Available 0.0147
6536 Histidine ammonia-lyase hutH 0.0147
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0147
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0147
2981 Phospholipase A2, membrane associated PLA2G2A 0.0145
38 Cystinosin CTNS 0.0141
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0141
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0141
341 5-hydroxytryptamine 3 receptor HTR3A 0.0139
1671 Excitatory amino acid transporter 3 SLC1A1 0.0137
4332 Modification methylase TaqI taqIM 0.0135
4310 rRNA adenine N-6-methyltransferase ermC' 0.0135
4306 HemK protein TM_0488 0.0135
2297 Genome polyprotein Not Available 0.0132
2322 Genome polyprotein Not Available 0.0132
2694 Genome polyprotein Not Available 0.0132
2719 Genome polyprotein Not Available 0.0132
2860 Genome polyprotein Not Available 0.0132
2928 Genome polyprotein Not Available 0.0132
3160 Genome polyprotein Not Available 0.0132
3260 Genome polyprotein Not Available 0.0132
4783 Genome polyprotein Not Available 0.0132
5726 Genome polyprotein Not Available 0.0132
5779 Genome polyprotein Not Available 0.0132
5867 Genome polyprotein Not Available 0.0132
6253 Genome polyprotein Not Available 0.0132
6301 Genome polyprotein Not Available 0.0132
6380 Genome polyprotein Not Available 0.0132
6381 Genome polyprotein Not Available 0.0132
6437 Genome polyprotein Not Available 0.0132
6520 Genome polyprotein Not Available 0.0132
6521 Genome polyprotein Not Available 0.0132
6652 Genome polyprotein Not Available 0.0132
6734 Genome polyprotein Not Available 0.0132
6735 Genome polyprotein Not Available 0.0132
6736 Genome polyprotein Not Available 0.0132
6737 Genome polyprotein Not Available 0.0132
6738 Genome polyprotein Not Available 0.0132
6739 Genome polyprotein Not Available 0.0132
6744 Genome polyprotein Not Available 0.0132
6748 Genome polyprotein Not Available 0.0132
6894 Genome polyprotein Not Available 0.0132
6898 Genome polyprotein Not Available 0.0132
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0132
3117 Carminomycin 4-O-methyltransferase dnrK 0.0131
4302 METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2 mmaA2 0.013
2242 Cyclopropane-fatty-acyl-phospholipid synthase 2 cmaA2 0.013
4318 Siroheme synthase cysG 0.0129
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0129
399 Tyrosyl-tRNA synthetase, mitochondrial YARS2 0.0127
2653 Modification methylase RsrI rsrIM 0.0124
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0123
492 Histamine H1 receptor HRH1 0.0123
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0122
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0122
3977 ASRGL1 protein ASRGL1 0.0121
4327 RdmB rdmB 0.0121
625 Glutamate carboxypeptidase 2 FOLH1 0.012
263 Neutral amino acid transporter B(0) SLC1A5 0.0119
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0118
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0117
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0113
6144 Solute carrier family 22 member 2 SLC22A2 0.011
701 Isoleucine-tRNA synthetase IARS 0.011
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.011
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.011
221 Lysyl-tRNA synthetase KARS 0.0109
2452 Tryptophanyl-tRNA synthetase trpS 0.0108
4311 tRNA TRDMT1 0.0108
4325 tRNA trmD 0.0108
4328 tRNA trmD 0.0108
923 Glutamate receptor 3 GRIA3 0.0108
4092 Probable asparaginyl-tRNA synthetase, mitochondrial NARS2 0.0107
669 Asparaginyl-tRNA synthetase, cytoplasmic NARS 0.0107
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0104
5650 NimA-related protein DR_0842 0.0101
624 Guanidinoacetate N-methyltransferase GAMT 0.0101
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.01
5646 Galactokinase GALK1 0.0099
5265 FtsH ftsH 0.0099
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0099
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0099
5302 TrwB trwB 0.0099
501 Leucine carboxyl methyltransferase 1 LCMT1 0.0097
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0097
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0097
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0097
2557 Cap-specific mRNA PAPS 0.0096
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0096
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0096
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0096
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0096
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0096
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0095
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0093
828 Phenylalanine-4-hydroxylase PAH 0.0092
3109 Phenylalanine-4-hydroxylase phhA 0.0092
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0089
5312 Kinesin-like protein KIF1A KIF1A 0.0088
4203 Histamine N-methyltransferase HNMT 0.0084
974 Phenylethanolamine N-methyltransferase PNMT 0.0084
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0083
2892 Acetylglutamate kinase argB 0.0083
3550 Acetylglutamate kinase argB 0.0083
2371 Pantothenate kinase coaA 0.0082
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0081
825 Arsenical pump-driving ATPase ASNA1 0.0081
3435 Arsenical pump-driving ATPase arsA 0.0081
2615 Chemotaxis protein cheA cheA 0.0081
1881 Hexokinase-1 HK1 0.0081
465 Calmodulin CALM1 0.008
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0079
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0077
2727 S-adenosylmethionine synthetase metK 0.0077
2697 Uridine-cytidine kinase 2 UCK2 0.0075
833 Organic cation/carnitine transporter 1 SLC22A4 0.0075
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0074
90 Tryptophan 5-hydroxylase 2 TPH2 0.0073
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0073
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0073
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0073
2300 Lysozyme E 0.0073
3633 Lysozyme R 0.0073
5597 Lysozyme 17 0.0073
5588 Cell division protein FtsY TM_0570 0.0073
5591 Complement component C8 gamma chain C8G 0.0073
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0073
5582 Regulator of transcription; stringent starvation protein A sspA 0.0073
4238 50S ribosomal protein L4 rplD 0.0073
5578 50S ribosomal protein L4 rplD 0.0073
6173 50S ribosomal protein L4 rplD 0.0073
6219 50S ribosomal protein L4 rplD 0.0073
4695 UPF0124 protein yfiH yfiH 0.0073
5060 Intron-associated endonuclease 1 ITEVIR 0.0073
5590 N utilization substance protein B homolog nusB 0.0073
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0073
5600 Pyruvate decarboxylase pdc 0.0073
2838 Ribose-5-phosphate isomerase A rpiA 0.0073
2952 Ribose-5-phosphate isomerase A rpiA 0.0073
5595 Ribose-5-phosphate isomerase A rpiA 0.0073
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0073
5593 Transferase Not Available 0.0073
4375 Glutamine synthetase 1 glnA1 0.0073
5575 Short tail fiber protein 12 0.0073
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0073
5587 Iron(III)-binding periplasmic protein fbpA 0.0073
5581 Beta-fructosidase bfrA 0.0073
5580 Hexon protein PII 0.0073
5574 Invasin YPTB1668 0.0073
4034 Glutaredoxin-1 GLRX 0.0072
4037 Hypothetical protein GPX1 0.0072
4297 Hypothetical protein SP_1951 0.0072
4521 Hypothetical protein BC_2969 0.0072
4540 Hypothetical protein TM_1070 0.0072
4555 Hypothetical protein MT1739 0.0072
4569 Hypothetical protein mshD 0.0072
4578 Hypothetical protein PA3270 0.0072
4747 Hypothetical protein PA3967 0.0072
5177 Hypothetical protein TM_0096 0.0072
5194 Hypothetical protein PA1204 0.0072
5240 Hypothetical protein Rv2991 0.0072
5370 Hypothetical protein TM_1158 0.0072
5710 Hypothetical protein Tb927.5.1360 0.0072
4038 Glutathione peroxidase 4 GPX4 0.0072
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0072
4035 Glutathione S-transferase Mu 5 GSTM5 0.0072
1928 Leukotriene C4 synthase LTC4S 0.0072
4029 Microsomal glutathione S-transferase 3 MGST3 0.0072
4032 Microsomal glutathione S-transferase 1 MGST1 0.0072
906 Glutathione peroxidase 1 GPX1 0.0072
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0072
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0072
4033 S-formylglutathione hydrolase ESD 0.0072
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0072
4036 Glutathione peroxidase 6 GPX6 0.0072
900 Glutathione S-transferase A4 GSTA4 0.0072
903 Glutathione S-transferase A5 GSTA5 0.0072
911 Glutathione peroxidase 3 GPX3 0.0072
4040 Glutathione peroxidase 7 GPX7 0.0072
907 Glutathione peroxidase 2 GPX2 0.0072
910 Epididymal secretory glutathione peroxidase GPX5 0.0072
4042 Glutathione transferase omega-2 GSTO2 0.0072
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0072
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0071
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.007
5641 Rod shape-determining protein MreB TM_0588 0.007
4178 DNA repair protein RAD51 homolog 1 RAD51 0.007
5649 Potassium-transporting ATPase B chain kdpB 0.007
3794 Osmolarity sensor protein envZ envZ 0.007
5644 Sensor protein phoQ phoQ 0.007
5643 General secretion pathway protein E epsE 0.007
5645 DNA topoisomerase 4 subunit B parE 0.007
6227 DNA topoisomerase 4 subunit B parE 0.007
5642 Chaperone clpB clpB 0.007
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.007
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.007
4992 Cytochrome c peroxidase Not Available 0.007
5682 Ribonuclease pancreatic RNASE1 0.0069
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0068
740 Argininosuccinate synthase ASS1 0.0067
865 Argininosuccinate synthase ASS1 0.0067
2680 Argininosuccinate synthase argG 0.0067
3194 Argininosuccinate synthase argG 0.0067
897 Glutathione S-transferase kappa 1 GSTK1 0.0066
594 Thyroxine-binding globulin SERPINA7 0.0066
2251 Thymidylate kinase tmk 0.0066
2254 Thymidylate kinase DTYMK 0.0066
3522 Thymidylate kinase tmk 0.0066
898 Glutathione S-transferase A3 GSTA3 0.0065
3319 Hydroxyacylglutathione hydrolase HAGH 0.0065
5006 RNASE4 protein RNASE4 0.0064
4533 Glyoxalase family protein BC_1747 0.0064
2555 Pol polyprotein pol 0.0064
3242 Pol polyprotein gag-pol 0.0064
3471 Pol polyprotein gag-pro-pol 0.0064
5256 Pol polyprotein pol 0.0064
6469 Pol polyprotein gag-pol 0.0064
6565 Pol polyprotein Not Available 0.0064
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0064
4751 Mitogen-activated protein kinase 12 MAPK12 0.0064
921 Glutamate receptor 2 GRIA2 0.0063
5328 Prostaglandin F synthase Tb11.02.2310 0.0063
3729 Citrate synthase gltA 0.0063
4575 Citrate synthase cit 0.0063
4580 Citrate synthase gltA 0.0063
909 Maleylacetoacetate isomerase GSTZ1 0.0063
3132 Tryptophan synthase alpha chain trpA 0.0062
6568 Tryptophan synthase alpha chain trpA 0.0062
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0062
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0062
2852 DNA mismatch repair protein mutL mutL 0.0062
2397 Dihydroxyacetone kinase dhaK 0.0061
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0061
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0061
3822 Actin, alpha skeletal muscle ACTA1 0.0061
758 Thyroid hormone receptor alpha THRA 0.0061
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0059
765 Indoleamine 2,3-dioxygenase IDO1 0.0059
2521 Cell division protein ftsZ ftsZ 0.0059
3301 Cell division protein ftsZ ftsZ 0.0059
2603 Beta-lactamase II blm 0.0058
2149 Angiogenin ANG 0.0058
3583 6-phosphogluconolactonase pgl 0.0058
2165 Glutathione S-transferase Mu 2 GSTM2 0.0058
4041 Microsomal glutathione S-transferase 2 MGST2 0.0058
899 Glutathione S-transferase Mu 3 GSTM3 0.0058
905 Glutathione transferase omega-1 GSTO1 0.0057
857 Malate dehydrogenase, mitochondrial MDH2 0.0057
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0057
3231 Death-associated protein kinase 1 DAPK1 0.0056
1721 Glycogen synthase kinase-3 beta GSK3B 0.0056
3486 Fumarate hydratase class II fumC 0.0055
134 Tryptophan 5-hydroxylase 1 TPH1 0.0055
2286 Isocitrate dehydrogenase [NADP] icd 0.0055
2302 Isocitrate dehydrogenase [NADP] icd 0.0055
2771 Isocitrate dehydrogenase [NADP] icd 0.0055
2942 Sialidase nanH 0.0054
3546 Sialidase nedA 0.0054
901 Glutathione S-transferase Mu 4 GSTM4 0.0054
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0054
887 DNA gyrase subunit B gyrB 0.0054
4150 DNA gyrase subunit B gyrB 0.0054
6225 DNA gyrase subunit B gyrB 0.0054
1123 Eosinophil cationic protein RNASE3 0.0054
332 Beta-lactamase blaZ 0.0054
2478 Beta-lactamase ampC 0.0054
2613 Beta-lactamase ampC 0.0054
2635 Beta-lactamase ampC 0.0054
2700 Beta-lactamase penP 0.0054
5445 Beta-lactamase blaB 0.0054
6019 Beta-lactamase SHV-7 0.0054
6701 Beta-lactamase cphA 0.0054
346 Thyroid hormone receptor beta-1 THRB 0.0054
6012 Tryptophan 2,3-dioxygenase TDO2 0.0053
936 Ephrin type-A receptor 2 EPHA2 0.0053
958 Insulin-like growth factor 1 receptor IGF1R 0.0053
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0053
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0051
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.005
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.005
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.005
577 Argininosuccinate lyase ASL 0.0049
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0049
1313 Lactoylglutathione lyase GLO1 0.0049
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0048
317 Methionine-R-sulfoxide reductase SEPX1 0.0048
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0048
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0048
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0048
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0048
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0047
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0047
5579 Carboxypeptidase B CPB1 0.0047
4031 Glutathione S-transferase A1 GSTA1 0.0047
128 Adenine phosphoribosyltransferase APRT 0.0047
4192 DNA topoisomerase 2-beta TOP2B 0.0046
6141 Sodium/bile acid cotransporter SLC10A1 0.0046
3384 Macrophage migration inhibitory factor MIF 0.0046
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0045
908 Glutathione S-transferase theta-1 GSTT1 0.0045
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0045
714 Glutathione reductase, mitochondrial GSR 0.0043
3932 Glutathione S-transferase A2 GSTA2 0.0042
896 Glutathione S-transferase Mu 1 GSTM1 0.0042
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0042
191 Peptide methionine sulfoxide reductase MSRA 0.0041
373 Transthyretin TTR 0.004
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.004
1836 Mitogen-activated protein kinase 10 MAPK10 0.004
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0038
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0038
904 Glutathione S-transferase P GSTP1 0.0038
5293 Shikimate kinase 2 aroL 0.0038
5288 Shikimate kinase aroK 0.0038
5304 UPF0166 protein TM_0021 TM_0021 0.0038
5287 Signaling protein Not Available 0.0038
5292 Putative partitioning protein TT_C1605 0.0038
5266 Activator of hgdC 0.0038
5259 Transcriptional regulator ntrC1 0.0038
6699 Transcriptional regulator Cgl2612 0.0038
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0038
3199 Phosphopantetheine adenylyltransferase coaD 0.0038
3543 Phosphopantetheine adenylyltransferase coaD 0.0038
3567 Phosphopantetheine adenylyltransferase coaD 0.0038
5289 Phosphopantetheine adenylyltransferase coaD 0.0038
2874 Nitrogenase iron protein 1 nifH1 0.0038
4346 Polynucleotide kinase pseT 0.0038
5283 D-alanine--D-alanine ligase B ddlB 0.0038
5281 Plasmid segregation protein parM parM 0.0038
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0038
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0038
5315 Chaperone protein htpG htpG 0.0038
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0038
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0038
5291 Glycogen synthase 1 glgA1 0.0038
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0038
5264 DNA replication protein REP 0.0038
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0038
5308 Preprotein translocase secA 1 subunit secA1 0.0038
5285 Kinesin heavy chain KIF5B 0.0038
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0038
5299 D-alanine--D-alanine ligase ddl 0.0038
6598 D-alanine--D-alanine ligase ddl 0.0038
5284 Large T antigen Not Available 0.0038
5276 Chromosomal replication initiator protein dnaA dnaA 0.0038
5277 Preprotein translocase subunit secA secA 0.0038
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0038
2236 Casein kinase II subunit alpha CSNK2A1 0.0037
6136 Multidrug resistance-associated protein 5 ABCC5 0.0036
822 Aldose reductase AKR1B1 0.0036
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0035
4085 Peptidyl-prolyl cis-trans isomerase C PPIC 0.0035
4088 Probable prolyl-tRNA synthetase, mitochondrial PARS2 0.0035
4083 Peptidyl-prolyl cis-trans isomerase H PPIH 0.0035
4087 Pyrroline 5-carboxylate reductase isoform P5CR2 0.0035
4090 Chromosome 14 open reading frame 149 C14orf149 0.0035
4082 Proline oxidase, mitochondrial PRODH 0.0035
797 Sodium-dependent proline transporter SLC6A7 0.0035
4086 Peptidyl-prolyl cis-trans isomerase G PPIG 0.0035
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0034
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0033
6142 Solute carrier family 22 member 8 SLC22A8 0.0033
840 Methionine synthase reductase, mitochondrial MTRR 0.0033
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0032
163 D(1B) dopamine receptor DRD5 0.0032
2632 Adenylosuccinate synthetase purA 0.0031
3323 Adenylosuccinate synthetase purA 0.0031
3975 Adenylosuccinate synthetase ADSS 0.0031
4598 Adenylosuccinate synthetase Adss 0.0031
6817 Adenylosuccinate synthetase purA 0.0031
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.0031
533 Aminoacylase-1 ACY1 0.0031
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.0031
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.0031
209 Aspartoacylase ASPA 0.0031
3979 Aspartoacylase-2 ACY3 0.0031
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.0031
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.0031
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.0031
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.0031
3426 Glutamine synthetase glnA 0.0031
3987 Glutamine synthetase GLUL 0.0031
3175 Glutamate--cysteine ligase gshA 0.0031
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.003
432 D(4) dopamine receptor DRD4 0.003
2164 Multidrug resistance-associated protein 4 ABCC4 0.003
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.003
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.003
5189 Trimethylamine dehydrogenase tmd 0.003
4106 Guanylate kinase GUK1 0.003
4516 Guanylate kinase gmk 0.003
2270 Dephospho-CoA kinase coaE 0.003
2284 Adenylate kinase adk 0.003
2296 Adenylate kinase adk 0.003
2311 Adenylate kinase adk 0.003
2312 Adenylate kinase Not Available 0.003
6277 Heat shock cognate 71 kDa protein HSPA8 0.003
4837 Cag-alfa cag-alfa 0.003
4839 DNA polymerase III subunit tau dnaX 0.003
4774 NTPase P4 Not Available 0.003
4838 PMS1 protein homolog 2 PMS2 0.003
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.003
638 D(3) dopamine receptor DRD3 0.0029
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0029
7 Nitric oxide synthase, inducible NOS2 0.0029
1008 CTP synthase 1 CTPS 0.0029
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0029
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0029
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0029
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0029
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0029
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0029
3989 Glutaminyl-tRNA synthetase QARS 0.0029
291 Nitric-oxide synthase, endothelial NOS3 0.0029
2683 Mono-ADP-ribosyltransferase C3 C3 0.0029
340 Apoptotic protease-activating factor 1 APAF1 0.0028
5300 Antigen peptide transporter 1 TAP1 0.0028
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0027
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0027
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0027
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0027
2554 Peptidyl-prolyl cis-trans isomerase, mitochondrial PPIF 0.0027
5271 Focal adhesion kinase 1 PTK2 0.0027
2390 Nonsecretory ribonuclease RNASE2 0.0027
2922 Glycerol kinase glpK 0.0027
2795 Methionine aminopeptidase 2 METAP2 0.0026
23 D(1A) dopamine receptor DRD1 0.0026
2282 Protein recA recA 0.0026
2315 Protein recA recA 0.0026
2332 Protein recA recA 0.0026
5263 Protein recA recA 0.0026
789 Alpha-1D adrenergic receptor ADRA1D 0.0026
408 Riboflavin kinase RFK 0.0026
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0025
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0025
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0025
788 Creatine kinase M-type CKM 0.0025
378 Alpha-2C adrenergic receptor ADRA2C 0.0025
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0025
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0025
3669 Ribokinase rbsK 0.0025
831 D(2) dopamine receptor DRD2 0.0024
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0024
629 Alpha-2B adrenergic receptor ADRA2B 0.0024
118 Organic cation/carnitine transporter 2 SLC22A5 0.0024
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0024
193 Beta-1 adrenergic receptor ADRB1 0.0024
6 Coagulation factor XIII A chain F13A1 0.0024
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0023
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0023
766 Beta-2 adrenergic receptor ADRB2 0.0023
2334 Dethiobiotin synthetase bioD 0.0023
6555 Dethiobiotin synthetase bioD 0.0023
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0023
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0023
632 Alpha-1B adrenergic receptor ADRA1B 0.0023
413 Amidophosphoribosyltransferase PPAT 0.0023
2515 Amidophosphoribosyltransferase purF 0.0023
3714 Amidophosphoribosyltransferase purF 0.0023
318 Alpha-2A adrenergic receptor ADRA2A 0.0022
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0021
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0021
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0021
48 Pyridoxal kinase PDXK 0.0021
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0021
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0021
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0021
702 UMP-CMP kinase CMPK1 0.0021
2091 Endoplasmin HSP90B1 0.002
556 Alpha-1A adrenergic receptor ADRA1A 0.002
6395 Myosin-14 MYH14 0.002
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.002
1422 Serine/threonine-protein kinase 6 AURKA 0.0019
3379 Kinesin-like protein KIF11 KIF11 0.0019
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0019
504 Mast/stem cell growth factor receptor KIT 0.0019
509 Thymidine kinase TK 0.0018
570 Thymidine kinase TK 0.0018
2559 Thymidine kinase TK 0.0018
3430 Thymidine kinase tdk 0.0018
3518 Thymidine kinase TK 0.0018
5301 Thymidine kinase tdk 0.0018
5771 Thymidine kinase ORF36 0.0018
7009 Thymidine kinase ORF36 0.0018
5294 Nucleoside diphosphate kinase A NME1 0.0017
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0017
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0017
4773 Deoxycytidine kinase DCK 0.0017
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0014
4924 Cytochrome P450 2C8 CYP2C8 0.0013
↑