DT-Web

DB01583 - Liotrix


Identification
Name Liotrix
Accession Number DB01583
Type small molecule
Description Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion. It is now known that the thyroid gland secretes approximately ten times more T4 than T3 and that 80% of serum T3 is derived from deiodination of T4 in peripheral tissues. Administration of levothyroxine alone is sufficient for maintaining serum T4 and T3 levels in most patients and combination hormone replacement therapy generally offers no therapeutic advantage. In fact, administration of T3 may result in supratherapeutic levels of T3.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 1471.8072
Groups approved
Monoisotopic Weight 1471.440608948
Pharmacology
Indication May be used to treat primary, secondary or tertiary hypothyroidism. May also be used to suppress thyroid stimulating hormone (TSH) secretion in patients with simple (nontoxic) goiter, subacute or chronic lymphocytic thyroiditis multinodular goiter, and in the management of thyroid cancer. May be used in conjunction with other antithyroid agents to treat thyrotoxicosis to prevent goitrogenesis and hypothyroidism. May also be used for differential diagnosis of suspected mild hyperthyroidism or thyroid gland autonomy.
Mechanism of action The hormones, T4 and T3, are tyrosine-based hormones produced by the thyroid gland. Iodine is an important component in their synthesis. The major secreted form of thyroid hormone is T4. T4 is converted T3, the more active thyroid hormone, by deiodinases in peripheral tissues. T3 acts in the body to increase basal metabolic rate, alter protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline). Thyroid hormones are essential for proper development and differentiation of all cells of the human body. T4 and T3 regulate protein, fat and carbohydrate metabolism to varying extents. The most pronounced effect of the hormones is in altering how human cells use energetic compounds. The thyroid hormone derivatives bind to the thyroid hormone receptors initially to initiate their downstream effects.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Thyroid hormones are primarily eliminated by the kidneys.
Toxicity Hypermetabolic state indistinguishable from thyrotoxicosis of endogenous origin. Symptoms of thyrotoxicosis include weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, tachycardia, increased pulse and blood pressure, cardiac arrhythmias, tremors, insomnia, heat intolerance, fever, and menstrual irregularities.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Calcium Acetate Calcium salts such as calcium acetate may diminish the therapeutic effect of thyroid products such as liotrix. Separate the doses of the thyroid product and the oral calcium supplement by at least 4 hours. Monitor for decreased therapeutic effects of thyroid products if an oral calcium supplement is initiated/dose increased, or increased effects if an oral calcium supplement is discontinued/dose decreased.
Cholestyramine The resin, cholestyramine, decreases the absorption of the thyroid hormone, liotrix.
Colestipol The resin, colestipol, decreases the absorption of the thyroid hormone, liotrix.
Digoxin The thyroid hormone, liotrix, decreases the effect of digoxin.
Warfarin Liotrix may contribute to the anticoagulant effect of warfarin by increasing the metabolism of vitamin K-dependent clotting factors. Monitor for changes in prothrombin time and anticoagulant effects if liotrix is initiated, discontinued or dose changed.
Food Interactions
  • Absorption increased in fasting state and decreased in malabsorption states.
  • Consistent administration in relation to meals is recommended.
  • Oral administration with infant soybean formula, soybean flour, cotton seed meal, walnuts, foods containing large amounts of fiber, ferrous sulfate, and antacids may decrease drug absorption.
  • Take 30-60 minutes before breakfast.
  • Iron and calcium may interfere with absorption. Space doses at least one hour before or after iron or calcium intake.

Targets


Thyroid hormone receptor alpha
Name Thyroid hormone receptor alpha
Gene Name THRA
Pharmacological action yes
Actions agonist
References
  • Jiang W, Miyamoto T, Kakizawa T, Sakuma T, Nishio S, Takeda T, Suzuki S, Hashizume K: Expression of thyroid hormone receptor alpha in 3T3-L1 adipocytes; triiodothyronine increases the expression of lipogenic enzyme and triglyceride accumulation. J Endocrinol. 2004 Aug;182(2):295-302. - Pubmed
  • Kariv R, Enden A, Zvibel I, Rosner G, Brill S, Shafritz DA, Halpern Z, Oren R: Triiodothyronine and interleukin-6 (IL-6) induce expression of HGF in an immortalized rat hepatic stellate cell line. Liver Int. 2003 Jun;23(3):187-93. - Pubmed
  • Mai W, Janier MF, Allioli N, Quignodon L, Chuzel T, Flamant F, Samarut J: Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10332-7. Epub 2004 Jul 6. - Pubmed
  • Sciaudone MP, Yao L, Schaller M, Zinn SA, Freake HC: Diethylenetriaminepentaacetic acid enhances thyroid hormone action by a transcriptional mechanism. Biol Trace Elem Res. 2004 Summer;99(1-3):219-31. - Pubmed
  • Timmer DC, Bakker O, Wiersinga WM: Triiodothyronine affects the alternative splicing of thyroid hormone receptor alpha mRNA. J Endocrinol. 2003 Nov;179(2):217-25. - Pubmed
  • Bernal J: Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59. - Pubmed
  • Nakajima Y, Yamada M, Horiguchi K, Satoh T, Hashimoto K, Tokuhiro E, Onigata K, Mori M: Resistance to thyroid hormone due to a novel thyroid hormone receptor mutant in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor. Thyroid. 2010 Aug;20(8):917-26. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
DTHybrid score 0.717
Thyroid hormone receptor beta-1
Name Thyroid hormone receptor beta-1
Gene Name THRB
Pharmacological action yes
Actions agonist
References
  • Bernal J: Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59. - Pubmed
  • Gonzalez-Sancho JM, Garcia V, Bonilla F, Munoz A: Thyroid hormone receptors/THR genes in human cancer. Cancer Lett. 2003 Mar 31;192(2):121-32. - Pubmed
  • Yen PM, Feng X, Flamant F, Chen Y, Walker RL, Weiss RE, Chassande O, Samarut J, Refetoff S, Meltzer PS: Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice. EMBO Rep. 2003 Jun;4(6):581-7. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
  • Wu SY, Sadow PM, Refetoff S, Weiss RE: Tissue responses to thyroid hormone in a kindred with resistance to thyroid hormone harboring a commonly occurring mutation in the thyroid hormone receptor beta gene (P453T). J Lab Clin Med. 2005 Aug;146(2):85-94. - Pubmed
  • Marazuela M, Nattero L, Moure D, Garcia-Polo I, Figueroa-Vega N, Guijarro C: Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment. Thyroid. 2008 Oct;18(10):1119-23. - Pubmed
  • Sivakumar T, Chaidarun S: Resistance to thyroid hormone in a patient with coexisting Graves' disease. Thyroid. 2010 Feb;20(2):213-6. - Pubmed
  • Grasberger H, Ringkananont U, Croxson M, Refetoff S: Resistance to thyroid hormone in a patient with thyroid dysgenesis. Thyroid. 2005 Jul;15(7):730-3. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
DTHybrid score 1.4679

Enzymes


Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed
DTHybrid score 0.3779

Transporters


Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions substrate
References
  • Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, Seki M, Shiiba K, Suzuki M, Kondo Y, Nunoki K, Shimosegawa T, Iinuma K, Ito S, Matsuno S, Abe T: Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. - Pubmed
  • Friesema EC, Docter R, Moerings EP, Stieger B, Hagenbuch B, Meier PJ, Krenning EP, Hennemann G, Visser TJ: Identification of thyroid hormone transporters. Biochem Biophys Res Commun. 1999 Jan 19;254(2):497-501. - Pubmed
DTHybrid score 0.5504
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions substrate
References
  • Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H: Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem. 1999 Jun 11;274(24):17159-63. - Pubmed
DTHybrid score 0.6288
Solute carrier organic anion transporter family member 1B3
Name Solute carrier organic anion transporter family member 1B3
Gene Name SLCO1B3
Actions substrate
References
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
  • Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R, Adachi H, Fujiwara K, Okabe M, Suzuki T, Nunoki K, Sato E, Kakyo M, Nishio T, Sugita J, Asano N, Tanemoto M, Seki M, Date F, Ono K, Kondo Y, Shiiba K, Suzuki M, Ohtani H, Shimosegawa T, Iinuma K, Nagura H, Ito S, Matsuno S: LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. - Pubmed
DTHybrid score 0.4979
Solute carrier organic anion transporter family member 4C1
Name Solute carrier organic anion transporter family member 4C1
Gene Name SLCO4C1
Actions substrate
References
  • Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. Epub 2004 Mar 1. - Pubmed
DTHybrid score 0.5099
Sodium/bile acid cotransporter
Name Sodium/bile acid cotransporter
Gene Name SLC10A1
Actions substrate
References
  • Friesema EC, Docter R, Moerings EP, Stieger B, Hagenbuch B, Meier PJ, Krenning EP, Hennemann G, Visser TJ: Identification of thyroid hormone transporters. Biochem Biophys Res Commun. 1999 Jan 19;254(2):497-501. - Pubmed
DTHybrid score 0.3258
Solute carrier organic anion transporter family member 1C1
Name Solute carrier organic anion transporter family member 1C1
Gene Name SLCO1C1
Actions substrate,inhibitor
References
  • Westholm DE, Stenehjem DD, Rumbley JN, Drewes LR, Anderson GW: Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. Endocrinology. 2009 Feb;150(2):1025-32. Epub 2008 Oct 9. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
  • Tohyama K, Kusuhara H, Sugiyama Y: Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Endocrinology. 2004 Sep;145(9):4384-91. Epub 2004 May 27. - Pubmed
  • Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. - Pubmed
DTHybrid score 0.4795
Solute carrier organic anion transporter family member 4A1
Name Solute carrier organic anion transporter family member 4A1
Gene Name SLCO4A1
Actions substrate,inhibitor
References
  • Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, Seki M, Shiiba K, Suzuki M, Kondo Y, Nunoki K, Shimosegawa T, Iinuma K, Ito S, Matsuno S, Abe T: Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. - Pubmed
  • Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. Epub 2004 Mar 1. - Pubmed
DTHybrid score 0.458
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4. - Pubmed
DTHybrid score 0.4336
Monocarboxylate transporter 8
Name Monocarboxylate transporter 8
Gene Name SLC16A2
Actions inhibitor
References
  • Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ: Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem. 2003 Oct 10;278(41):40128-35. Epub 2003 Jul 18. - Pubmed
DTHybrid score 0.3371
Monocarboxylate transporter 10
Name Monocarboxylate transporter 10
Gene Name SLC16A10
Actions inhibitor
References
  • Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. - Pubmed
DTHybrid score 0.4896
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inducer
References
  • Siegmund W, Altmannsberger S, Paneitz A, Hecker U, Zschiesche M, Franke G, Meng W, Warzok R, Schroeder E, Sperker B, Terhaag B, Cascorbi I, Kroemer HK: Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition. Clin Pharmacol Ther. 2002 Sep;72(3):256-64. - Pubmed
  • Ashida K, Katsura T, Motohashi H, Saito H, Inui K: Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells. Am J Physiol Gastrointest Liver Physiol. 2002 Apr;282(4):G617-23. - Pubmed
DTHybrid score 0.5596

Carriers


Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions
References Not Available
DTHybrid score 0.5504
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions
References Not Available
DTHybrid score 0.6288
Solute carrier organic anion transporter family member 1B3
Name Solute carrier organic anion transporter family member 1B3
Gene Name SLCO1B3
Actions
References Not Available
DTHybrid score 0.4979
Solute carrier organic anion transporter family member 4C1
Name Solute carrier organic anion transporter family member 4C1
Gene Name SLCO4C1
Actions
References Not Available
DTHybrid score 0.5099
Sodium/bile acid cotransporter
Name Sodium/bile acid cotransporter
Gene Name SLC10A1
Actions
References Not Available
DTHybrid score 0.3258
Solute carrier organic anion transporter family member 1C1
Name Solute carrier organic anion transporter family member 1C1
Gene Name SLCO1C1
Actions
References Not Available
DTHybrid score 0.4795
Solute carrier organic anion transporter family member 4A1
Name Solute carrier organic anion transporter family member 4A1
Gene Name SLCO4A1
Actions
References Not Available
DTHybrid score 0.458
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions
References Not Available
DTHybrid score 0.4336
Monocarboxylate transporter 8
Name Monocarboxylate transporter 8
Gene Name SLC16A2
Actions
References Not Available
DTHybrid score 0.3371
Monocarboxylate transporter 10
Name Monocarboxylate transporter 10
Gene Name SLC16A10
Actions
References Not Available
DTHybrid score 0.4896
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.5596

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.3656
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.319
4757 Cytochrome P450 2C9 CYP2C9 0.2317
1729 Solute carrier family 22 member 6 SLC22A6 0.2143
6016 Cytochrome P450 2C19 CYP2C19 0.1804
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1751
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1645
4118 Cytochrome P450 3A5 CYP3A5 0.1623
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.1525
1024 Solute carrier family 22 member 11 SLC22A11 0.1479
4119 Cytochrome P450 2D6 CYP2D6 0.1447
776 Bile salt export pump ABCB11 0.1416
4200 Cytochrome P450 1A2 CYP1A2 0.14
862 Multidrug resistance-associated protein 1 ABCC1 0.1328
2164 Multidrug resistance-associated protein 4 ABCC4 0.1229
6369 Thyroid hormone receptor, alpha isoform 1 variant Not Available 0.1207
6143 Solute carrier family 22 member 7 SLC22A7 0.1151
6107 Cytochrome P450 3A7 CYP3A7 0.1039
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.103
6030 Cytochrome P450 2B6 CYP2B6 0.0994
563 Thyroid peroxidase TPO 0.0957
20 Prostaglandin G/H synthase 1 PTGS1 0.0949
6024 Cytochrome P450 1A1 CYP1A1 0.093
6145 Solute carrier family 22 member 1 SLC22A1 0.0928
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0909
6167 Organic solute transporter subunit beta OSTB 0.0878
6166 Organic solute transporter subunit alpha OSTA 0.0878
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0841
290 Prostaglandin G/H synthase 2 PTGS2 0.0803
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0777
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0774
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.076
738 Monocarboxylate transporter 1 SLC16A1 0.0661
399 Tyrosyl-tRNA synthetase, mitochondrial YARS2 0.0654
3587 Gastrotropin FABP6 0.0651
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0641
6013 Cytochrome P450 2E1 CYP2E1 0.0639
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0637
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0614
136 Estrogen receptor ESR1 0.0596
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0573
118 Organic cation/carnitine transporter 2 SLC22A5 0.0562
763 Tyrosine aminotransferase TAT 0.0536
5493 Tyrosine aminotransferase Not Available 0.0536
6148 Multidrug resistance-associated protein 7 ABCC10 0.0534
6144 Solute carrier family 22 member 2 SLC22A2 0.0528
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0509
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0495
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0489
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0489
676 Tyrosine 3-monooxygenase TH 0.0488
33 Cystine/glutamate transporter SLC7A11 0.0484
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0479
501 Leucine carboxyl methyltransferase 1 LCMT1 0.0467
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0466
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0466
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0466
833 Organic cation/carnitine transporter 1 SLC22A4 0.0447
1898 Cytochrome P450 1B1 CYP1B1 0.0446
5718 Cytochrome P450 2A6 CYP2A6 0.0431
70 Type-1 angiotensin II receptor AGTR1 0.0426
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0425
1566 Corticoliberin CRH 0.0413
6136 Multidrug resistance-associated protein 5 ABCC5 0.0393
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0383
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0382
90 Tryptophan 5-hydroxylase 2 TPH2 0.0382
3811 Cytochrome P450 19A1 CYP19A1 0.0372
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0371
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.036
6149 Solute carrier family 22 member 10 SLC22A10 0.036
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0357
6106 Cytochrome P450 2C18 CYP2C18 0.0354
756 Sex hormone-binding globulin SHBG 0.0339
765 Indoleamine 2,3-dioxygenase IDO1 0.033
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0325
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0321
4604 Liver carboxylesterase 1 CES1 0.0314
6147 Solute carrier family 22 member 3 SLC22A3 0.0306
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0299
869 Estrogen receptor beta ESR2 0.0293
489 Monocarboxylate transporter 2 SLC16A7 0.0292
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0289
2532 Pantoate--beta-alanine ligase panC 0.0285
6012 Tryptophan 2,3-dioxygenase TDO2 0.0276
952 Dipeptidyl peptidase 4 DPP4 0.0275
134 Tryptophan 5-hydroxylase 1 TPH1 0.027
2452 Tryptophanyl-tRNA synthetase trpS 0.0269
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0266
146 Androgen receptor AR 0.0262
6645 D-amino-acid oxidase DAO 0.0259
1275 Estrogen sulfotransferase SULT1E1 0.0256
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0253
275 Arachidonate 5-lipoxygenase ALOX5 0.0251
871 Glucocorticoid receptor NR3C1 0.0251
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0243
492 Histamine H1 receptor HRH1 0.0239
891 Dihydropteroate synthase folP 0.0238
5359 Dihydropteroate synthase folP 0.0238
7175 Dihydropteroate synthase sulI 0.0238
6085 Fatty acid-binding protein, intestinal FABP2 0.0236
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0231
5925 Neuropeptide Y NPY 0.0231
314 System N amino acid transporter 1 SLC38A3 0.0229
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0227
2183 Fatty acid-binding protein, adipocyte FABP4 0.0227
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0224
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0219
397 Monocarboxylate transporter 3 SLC16A8 0.0218
195 Monocarboxylate transporter 7 SLC16A6 0.0218
218 Monocarboxylate transporter 5 SLC16A4 0.0218
429 Monocarboxylate transporter 6 SLC16A5 0.0217
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0217
731 HIV-1 protease HIV-1 protease 0.0216
244 Angiotensin-converting enzyme ACE 0.0212
29 Tubulin beta-1 chain TUBB1 0.0206
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.02
831 D(2) dopamine receptor DRD2 0.0199
4069 Threonyl-tRNA synthetase, mitochondrial TARS2 0.0197
261 Threonyl-tRNA synthetase, cytoplasmic TARS 0.0197
246 Valyl-tRNA synthetase VARS 0.0196
6020 Aldehyde oxidase AOX1 0.0194
500 Monocarboxylate transporter 4 SLC16A3 0.0193
6258 Protein S100-A7 S100A7 0.0191
6137 Multidrug resistance-associated protein 6 ABCC6 0.019
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0188
3810 Catechol O-methyltransferase COMT 0.0188
556 Alpha-1A adrenergic receptor ADRA1A 0.0184
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0183
578 Endothelin-1 receptor EDNRA 0.0182
5818 Folate receptor alpha FOLR1 0.018
558 Solute carrier family 12 member 1 SLC12A1 0.018
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0179
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0177
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0174
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0174
380 Cytochrome P450 17A1 CYP17A1 0.0173
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0173
502 5-hydroxytryptamine 2A receptor HTR2A 0.0172
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.017
1389 Transforming growth factor beta-1 TGFB1 0.0169
5469 Head decoration protein shp 0.0168
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0168
824 Sodium-dependent serotonin transporter SLC6A4 0.0167
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0167
52 Pyruvate kinase isozymes R/L PKLR 0.0166
771 Pyruvate carboxylase, mitochondrial PC 0.0165
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0164
737 Mineralocorticoid receptor NR3C2 0.0164
540 Sodium-dependent noradrenaline transporter SLC6A2 0.016
2457 Bacillolysin nprS 0.016
543 Penicillin-binding protein 1B mrcB 0.0158
6186 Penicillin-binding protein 1B ponB 0.0158
6822 Penicillin-binding protein 1b pbp1b 0.0158
6844 Penicillin-binding protein 1b pbp1b 0.0158
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.0157
293 Gamma-glutamyl hydrolase GGH 0.0157
6031 Cytochrome P450 3A43 CYP3A43 0.0156
645 Penicillin-binding protein 1A mrcA 0.0155
5805 Penicillin-binding protein 1A ponA 0.0155
6185 Penicillin-binding protein 1A mrcA 0.0155
6799 Penicillin-binding protein 1A pbpA 0.0155
482 Glycine receptor subunit alpha-1 GLRA1 0.0154
3917 Methylenetetrahydrofolate reductase MTHFR 0.0153
534 Threonine synthase-like 1 THNSL1 0.0152
320 5-hydroxytryptamine 1A receptor HTR1A 0.0151
3941 Amine oxidase [flavin-containing] A MAOA 0.0151
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.015
23 D(1A) dopamine receptor DRD1 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0148
24 Thymidylate synthase TMP1 0.0148
359 Thymidylate synthase TYMS 0.0148
2626 Thymidylate synthase thyA 0.0148
2729 Thymidylate synthase thyA 0.0148
5352 Thymidylate synthase THYA 0.0148
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0148
815 Histidyl-tRNA synthetase, cytoplasmic HARS 0.0147
96 Histidine ammonia-lyase HAL 0.0147
6257 Histidine ammonia-lyase Not Available 0.0147
6536 Histidine ammonia-lyase hutH 0.0147
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0146
468 Cytochrome P450 4A11 CYP4A11 0.0146
904 Glutathione S-transferase P GSTP1 0.0145
3923 Cholinesterase BCHE 0.0145
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0144
6541 Peptostreptococcal albumin-binding protein pab 0.0142
38 Cystinosin CTNS 0.0141
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0141
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0141
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0141
3809 Estrogen-related receptor gamma ESRRG 0.0141
365 Dihydrofolate reductase DHFR 0.014
2381 Dihydrofolate reductase DFR1 0.014
2833 Dihydrofolate reductase Not Available 0.014
2931 Dihydrofolate reductase folA 0.014
3544 Dihydrofolate reductase folA 0.014
3682 Dihydrofolate reductase folA 0.014
6642 Dihydrofolate reductase folA 0.014
6756 Dihydrofolate reductase dfrA 0.014
6218 Pannexin-1 PANX1 0.0139
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0139
1650 Heme carrier protein 1 SLC46A1 0.0139
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0138
150 Cationic amino acid transporter 3 SLC7A3 0.0137
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0137
58 Cationic amino acid transporter 4 SLC7A4 0.0137
663 Solute carrier family 12 member 4 SLC12A4 0.0136
53 Solute carrier family 12 member 5 SLC12A5 0.0136
632 Alpha-1B adrenergic receptor ADRA1B 0.0134
124 Histamine H2 receptor HRH2 0.0134
847 Mu-type opioid receptor OPRM1 0.0134
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0132
520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2367 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
696 Kappa-type opioid receptor OPRK1 0.0132
2539 Tubulin alpha-1 chain TUBA4A 0.013
193 Beta-1 adrenergic receptor ADRB1 0.0127
310 Solute carrier family 12 member 2 SLC12A2 0.0127
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0126
467 Delta-type opioid receptor OPRD1 0.0124
844 Epidermal growth factor receptor EGFR 0.0123
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0122
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0121
3977 ASRGL1 protein ASRGL1 0.0121
2981 Phospholipase A2, membrane associated PLA2G2A 0.012
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.012
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
263 Neutral amino acid transporter B(0) SLC1A5 0.0119
273 Apoptosis regulator Bcl-2 BCL2 0.0118
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0118
3 Histidine decarboxylase HDC 0.0117
3947 Xanthine dehydrogenase/oxidase XDH 0.0117
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0116
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0115
2016 Dipeptidase 1 DPEP1 0.0115
349 Serine--pyruvate aminotransferase AGXT 0.0115
2211 Fatty acid-binding protein, heart FABP3 0.0114
5880 Thrombopoietin receptor MPL 0.0114
701 Isoleucine-tRNA synthetase IARS 0.011
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.011
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.011
766 Beta-2 adrenergic receptor ADRB2 0.011
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.011
2391 Ferrochelatase hemH 0.0109
6502 Ferrochelatase DKFZp686P18130 0.0109
1591 Ferrochelatase, mitochondrial FECH 0.0109
358 Cystathionine beta-synthase CBS 0.0109
614 Progesterone receptor PGR 0.0109
221 Lysyl-tRNA synthetase KARS 0.0109
4092 Probable asparaginyl-tRNA synthetase, mitochondrial NARS2 0.0107
669 Asparaginyl-tRNA synthetase, cytoplasmic NARS 0.0107
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0107
26 Vascular endothelial growth factor receptor 3 FLT4 0.0104
1 Peptidoglycan synthetase ftsI ftsI 0.0104
4155 Peptidoglycan synthetase ftsI ftsI 0.0104
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0103
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0103
1517 Beta-3 adrenergic receptor ADRB3 0.0102
5650 NimA-related protein DR_0842 0.0101
22 30S ribosomal protein S4 rpsD 0.0101
6714 30S ribosomal protein S4 rpsD 0.0101
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0101
465 Calmodulin CALM1 0.0101
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0101
725 5-hydroxytryptamine 1D receptor HTR1D 0.0101
3426 Glutamine synthetase glnA 0.0101
3987 Glutamine synthetase GLUL 0.0101
6501 Fatty acid-binding protein, liver FABP1 0.0101
1852 Microtubule-associated protein 2 MAP2 0.01
885 5-hydroxytryptamine 1B receptor HTR1B 0.01
338 DNA polymerase UL30 0.01
379 DNA polymerase UL54 0.01
697 DNA polymerase ORF28 0.01
2482 DNA polymerase 43 0.01
4104 DNA polymerase BALF5 0.01
32 Vascular endothelial growth factor receptor 1 FLT1 0.01
6182 Cytochrome P450 2J2 CYP2J2 0.01
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.0099
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0098
6033 High affinity interleukin-8 receptor A CXCR1 0.0097
789 Alpha-1D adrenergic receptor ADRA1D 0.0096
817 DNA topoisomerase 2-alpha TOP2A 0.0096
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0096
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0096
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0096
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0096
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0096
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0096
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0096
140 30S ribosomal protein S9 rpsI 0.0095
6719 30S ribosomal protein S9 rpsI 0.0095
6725 30S ribosomal protein S9 rpsI 0.0095
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0095
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0095
566 Serotransferrin TF 0.0094
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0094
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0094
6493 Cytochrome c oxidase subunit 6C COX6C 0.0094
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0094
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0094
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0094
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0094
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0094
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0094
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0094
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0094
6559 Cytochrome c oxidase subunit 2 ctaC 0.0094
6669 Cytochrome c oxidase subunit 2 ctaC 0.0094
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0094
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0094
6558 Cytochrome c oxidase subunit 1 ctaD 0.0094
504 Mast/stem cell growth factor receptor KIT 0.0093
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
5923 Microtubule-associated protein tau MAPT 0.0092
5924 Microtubule-associated protein 4 MAP4 0.0092
828 Phenylalanine-4-hydroxylase PAH 0.0092
3109 Phenylalanine-4-hydroxylase phhA 0.0092
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0092
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0092
407 Vascular endothelial growth factor receptor 2 KDR 0.0089
318 Alpha-2A adrenergic receptor ADRA2A 0.0089
6043 Putative G-protein coupled receptor 44 GPR44 0.0089
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0087
2540 Choloylglycine hydrolase cbh 0.0086
122 P2Y purinoceptor 12 P2RY12 0.0086
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0085
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0083
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0083
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0083
511 5-hydroxytryptamine 1F receptor HTR1F 0.0082
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0081
169 Cysteine desulfurase, mitochondrial NFS1 0.0081
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0081
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0079
6014 Cytochrome P450 2A13 CYP2A13 0.0079
115 Penicillin-binding protein 2 mrdA 0.0079
6069 Penicillin-binding protein 2 mrdA 0.0079
6118 Penicillin-binding protein 2 penA 0.0079
6187 Penicillin-binding protein 2 pbpA 0.0079
6686 Penicillin-binding protein 2 pbp2 0.0079
6939 Penicillin-binding protein 2 mrdA 0.0079
7163 Penicillin-binding protein 2 pbpA 0.0079
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0079
6042 Prostaglandin reductase 2 PTGR2 0.0078
183 Vascular endothelial growth factor A VEGFA 0.0078
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0078
260 Cytochrome P450 51 ERG11 0.0078
761 Cytochrome P450 51 ERG11 0.0078
3163 Cytochrome P450 51 cyp51 0.0078
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0077
1353 DNA topoisomerase 1 TOP1 0.0077
3552 DNA topoisomerase 1 topA 0.0077
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0077
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0076
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0076
184 L-serine dehydratase SDS 0.0076
431 Serine racemase SRR 0.0076
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0076
491 Serine palmitoyltransferase 1 SPTLC1 0.0076
727 Serine palmitoyltransferase 2 SPTLC2 0.0076
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0075
638 D(3) dopamine receptor DRD3 0.0075
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0075
4210 Toll-like receptor 4 TLR4 0.0074
341 5-hydroxytryptamine 3 receptor HTR3A 0.0073
1291 cAMP response element-binding protein CREB1 0.0072
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0072
5626 Nucleoside diphosphate kinase B NME2 0.0072
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0072
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0071
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0071
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0071
438 Taste receptor type 1 member 2 TAS1R2 0.0071
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0071
950 Alpha platelet-derived growth factor receptor PDGFRA 0.007
633 Penicillin-binding proteins 1A/1B pbpA 0.007
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0069
469 Annexin A1 ANXA1 0.0069
740 Argininosuccinate synthase ASS1 0.0069
865 Argininosuccinate synthase ASS1 0.0069
2680 Argininosuccinate synthase argG 0.0069
3194 Argininosuccinate synthase argG 0.0069
228 Beta platelet-derived growth factor receptor PDGFRB 0.0069
811 Translocator protein TSPO 0.0068
1192 Sulfotransferase 1A1 SULT1A1 0.0068
705 Glutamate receptor 1 GRIA1 0.0067
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0067
6500 Phospholipase A2 PLA2G1B 0.0066
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0066
36 Insulin receptor INSR 0.0066
768 FK506-binding protein 1A FKBP1A 0.0066
6102 Arylamine N-acetyltransferase 2 NAT2 0.0065
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0065
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0065
3686 Acyl-CoA thioesterase I precursor tesA 0.0065
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0065
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0065
1630 Integrin beta-2 ITGB2 0.0065
4120 NADPH--cytochrome P450 reductase POR 0.0065
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0065
1525 Heparin-binding growth factor 2 FGF2 0.0064
4238 50S ribosomal protein L4 rplD 0.0064
5578 50S ribosomal protein L4 rplD 0.0064
6173 50S ribosomal protein L4 rplD 0.0064
6219 50S ribosomal protein L4 rplD 0.0064
1867 Major prion protein PRNP 0.0064
629 Alpha-2B adrenergic receptor ADRA2B 0.0064
537 ATP synthase delta chain, mitochondrial ATP5D 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6220 Aryl hydrocarbon receptor AHR 0.0061
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0061
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0061
1313 Lactoylglutathione lyase GLO1 0.0061
590 5-hydroxytryptamine 2C receptor HTR2C 0.006
1757 Myeloperoxidase MPO 0.006
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.006
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.006
436 5-hydroxytryptamine 2B receptor HTR2B 0.0059
1405 Thiopurine S-methyltransferase TPMT 0.0059
5294 Nucleoside diphosphate kinase A NME1 0.0059
4237 50S ribosomal protein L22 rplV 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
3382 Glycolipid transfer protein GLTP 0.0058
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0058
517 Alcohol dehydrogenase 1C ADH1C 0.0058
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0058
532 Neutral amino acid transporter A SLC1A4 0.0057
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0057
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0057
887 DNA gyrase subunit B gyrB 0.0057
4150 DNA gyrase subunit B gyrB 0.0057
6225 DNA gyrase subunit B gyrB 0.0057
2021 Thrombomodulin THBD 0.0057
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0057
378 Alpha-2C adrenergic receptor ADRA2C 0.0056
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0055
3856 Fibroblast growth factor receptor 3 FGFR3 0.0055
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0055
6209 30S ribosomal protein S19 rpsS 0.0055
6712 30S ribosomal protein S19 rpsS 0.0055
6726 30S ribosomal protein S19 rpsS 0.0055
6207 30S ribosomal protein S14 rpsN 0.0055
735 Alanine aminotransferase 1 GPT 0.0055
3904 Alanine aminotransferase 2 GPT2 0.0055
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0054
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0054
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0054
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0054
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
284 DNA-directed RNA polymerase beta chain rpoB 0.0054
5773 DNA-directed RNA polymerase beta chain rpoB 0.0054
5353 Glutamate decarboxylase alpha gadA 0.0054
751 Potassium channel subfamily K member 6 KCNK6 0.0054
819 Penicillin-binding protein 4 dacB 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
6044 Serum paraoxonase/lactonase 3 PON3 0.0053
171 Cysteine dioxygenase CDO-1 0.0053
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0052
1314 Thiamine transporter 2 SLC19A3 0.0052
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0052
207 Glutathione synthetase GSS 0.0052
5269 Glutathione synthetase gshB 0.0052
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0052
4122 Histone deacetylase 2 HDAC2 0.0051
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0051
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0051
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0051
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0051
834 Arginase-2, mitochondrial ARG2 0.0051
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0051
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0051
6168 Solute carrier family 22 member 16 SLC22A16 0.0051
2616 Ganglioside GM2 activator GM2A 0.0051
3932 Glutathione S-transferase A2 GSTA2 0.005
232 Corticosteroid-binding globulin SERPINA6 0.005
3760 Penicillin-binding protein 5 precursor dacA 0.005
88 Retinoic acid receptor RXR-beta RXRB 0.005
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.005
161 Tubulin beta chain TUBB 0.005
312 Tubulin beta chain TUB2 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
7 Nitric oxide synthase, inducible NOS2 0.0049
577 Argininosuccinate lyase ASL 0.0049
162 Retinoic acid receptor gamma-1 RARG 0.0049
172 Potassium channel subfamily K member 1 KCNK1 0.0049
572 Integrin alpha-L ITGAL 0.0049
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0049
229 Retinoic acid receptor beta RARB 0.0049
499 Arginine decarboxylase ADC 0.0049
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0049
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0049
3939 Amine oxidase [flavin-containing] B MAOB 0.0049
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0048
1010 Cytochrome P450 51A1 CYP51A1 0.0048
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0048
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0048
317 Methionine-R-sulfoxide reductase SEPX1 0.0048
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0048
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0048
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0048
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0048
432 D(4) dopamine receptor DRD4 0.0048
730 Retinoic acid receptor alpha RARA 0.0048
1050 Bile salt sulfotransferase SULT2A1 0.0047
6677 Myelin P2 protein PMP2 0.0047
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0047
1198 Serum paraoxonase/arylesterase 1 PON1 0.0047
6223 Penicillin-binding protein 1C pbpC 0.0047
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0047
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0047
4217 Telomerase reverse transcriptase TERT 0.0047
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0046
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0046
551 Carnitine O-acetyltransferase CRAT 0.0046
6228 Nuclear receptor coactivator 1 NCOA1 0.0046
332 Beta-lactamase blaZ 0.0046
2478 Beta-lactamase ampC 0.0046
2613 Beta-lactamase ampC 0.0046
2635 Beta-lactamase ampC 0.0046
2700 Beta-lactamase penP 0.0046
5445 Beta-lactamase blaB 0.0046
6019 Beta-lactamase SHV-7 0.0046
6701 Beta-lactamase cphA 0.0046
65 Matrix metalloproteinase-9 Not Available 0.0046
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0045
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0045
2236 Casein kinase II subunit alpha CSNK2A1 0.0045
5934 Cytochrome P450 26A1 CYP26A1 0.0044
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0043
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.0043
163 D(1B) dopamine receptor DRD5 0.0043
6241 Nuclear receptor coactivator 2 NCOA2 0.0043
342 P protein [Includes: DNA-directed DNA polymerase P 0.0042
612 P protein [Includes: DNA-directed DNA polymerase P 0.0042
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0042
6138 Multidrug resistance protein 3 ABCB4 0.0042
777 Tumor necrosis factor TNF 0.0042
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0042
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0041
435 Kynureninase KYNU 0.0041
4654 Kynureninase kynU 0.0041
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0041
413 Amidophosphoribosyltransferase PPAT 0.0041
2515 Amidophosphoribosyltransferase purF 0.0041
3714 Amidophosphoribosyltransferase purF 0.0041
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0041
191 Peptide methionine sulfoxide reductase MSRA 0.0041
1760 Aminopeptidase N ANPEP 0.0041
6843 Aminopeptidase N pepN 0.0041
89 Cysteine sulfinic acid decarboxylase CSAD 0.004
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.004
5300 Antigen peptide transporter 1 TAP1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
626 Cysteine dioxygenase type 1 CDO1 0.004
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.004
198 Sodium channel protein type 10 subunit alpha SCN10A 0.004
976 Platelet glycoprotein IX GP9 0.004
6103 Arylamine N-acetyltransferase 1 NAT1 0.004
1792 Tissue-type plasminogen activator PLAT 0.004
474 Acetylcholinesterase ACHE 0.004
5787 Angiopoietin-1 receptor TEK 0.0039
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0039
5482 Sialidase-2 NEU2 0.0039
117 Sterol O-acyltransferase 1 SOAT1 0.0039
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0039
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0039
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0038
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0038
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0038
3685 Catabolite gene activator crp 0.0038
4655 Adenylate cyclase cyaC 0.0038
4759 Adenylate cyclase cyaB2 0.0038
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0038
459 Retinoic acid receptor RXR-alpha RXRA 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
2320 Thymidine kinase, cytosolic TK1 0.0037
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0037
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0036
713 Sodium-dependent dopamine transporter SLC6A3 0.0036
3616 Fatty acid-binding protein, epidermal FABP5 0.0036
5431 Lipid binding protein Not Available 0.0036
5433 UPF0230 protein TM_1468 TM_1468 0.0036
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0036
130 Prostacyclin synthase PTGIS 0.0036
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0036
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0036
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0036
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0036
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0036
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
868 Cystathionine gamma-lyase CTH 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
291 Nitric-oxide synthase, endothelial NOS3 0.0035
6171 Solute carrier family 28 member 3 SLC28A3 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
1541 Metalloproteinase mmp20 0.0035
509 Thymidine kinase TK 0.0035
570 Thymidine kinase TK 0.0035
2559 Thymidine kinase TK 0.0035
3430 Thymidine kinase tdk 0.0035
3518 Thymidine kinase TK 0.0035
5301 Thymidine kinase tdk 0.0035
5771 Thymidine kinase ORF36 0.0035
7009 Thymidine kinase ORF36 0.0035
4085 Peptidyl-prolyl cis-trans isomerase C PPIC 0.0035
4088 Probable prolyl-tRNA synthetase, mitochondrial PARS2 0.0035
4083 Peptidyl-prolyl cis-trans isomerase H PPIH 0.0035
4087 Pyrroline 5-carboxylate reductase isoform P5CR2 0.0035
4090 Chromosome 14 open reading frame 149 C14orf149 0.0035
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0035
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0035
4082 Proline oxidase, mitochondrial PRODH 0.0035
797 Sodium-dependent proline transporter SLC6A7 0.0035
4086 Peptidyl-prolyl cis-trans isomerase G PPIG 0.0035
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0034
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0034
5 Glutaminase liver isoform, mitochondrial GLS2 0.0034
917 Glutaminase kidney isoform, mitochondrial GLS 0.0034
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0034
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0034
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0034
5261 Phosphoribosylformylglycinamidine synthase purL 0.0034
319 Opioid receptor, sigma 1 OPRS1 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0034
1618 High affinity nerve growth factor receptor NTRK1 0.0034
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0034
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0033
1656 CYP2B protein CYP2B 0.0033
4103 Proteasome subunit beta type 2 PSMB2 0.0033
4102 Proteasome subunit beta type 5 PSMB5 0.0033
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
4101 Proteasome subunit beta type 1 PSMB1 0.0033
6459 Glycodelin PAEP 0.0033
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0033
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0033
2249 Aspartate aminotransferase aspC 0.0033
2671 Aspartate aminotransferase aspC 0.0033
5490 Aspartate aminotransferase Not Available 0.0033
1671 Excitatory amino acid transporter 3 SLC1A1 0.0033
840 Methionine synthase reductase, mitochondrial MTRR 0.0033
707 72 kDa type IV collagenase MMP2 0.0033
4760 Mll3241 protein mll3241 0.0032
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0032
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0032
5682 Ribonuclease pancreatic RNASE1 0.0032
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0032
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0032
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0032
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0032
595 Fibrinogen alpha chain FGA 0.0032
3877 Growth-inhibiting protein 18 GIG18 0.0031
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0031
2632 Adenylosuccinate synthetase purA 0.0031
3323 Adenylosuccinate synthetase purA 0.0031
3975 Adenylosuccinate synthetase ADSS 0.0031
4598 Adenylosuccinate synthetase Adss 0.0031
6817 Adenylosuccinate synthetase purA 0.0031
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
533 Aminoacylase-1 ACY1 0.0031
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.0031
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.0031
209 Aspartoacylase ASPA 0.0031
3979 Aspartoacylase-2 ACY3 0.0031
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.0031
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.0031
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.0031
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.0031
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0031
809 Methionine synthase MTR 0.0031
2935 Methionine synthase metH 0.0031
780 Retinoic acid receptor RXR-gamma RXRG 0.0031
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0031
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.003
84 Nuclear receptor 0B1 NR0B1 0.003
283 SEC14-like protein 2 SEC14L2 0.003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.003
426 Aspartate aminotransferase, mitochondrial GOT2 0.003
1992 Vitamin D-binding protein GC 0.003
4203 Histamine N-methyltransferase HNMT 0.003
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.003
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.003
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0029
527 Prostacyclin receptor PTGIR 0.0029
1008 CTP synthase 1 CTPS 0.0029
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0029
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0029
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0029
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0029
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0029
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0029
3989 Glutaminyl-tRNA synthetase QARS 0.0029
1629 Transcription factor AP-1 JUN 0.0029
683 Potassium transporter GK0582 0.0029
672 Prostaglandin F2-alpha receptor PTGFR 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
2207 Rhodopsin RHO 0.0028
760 Fibroblast growth factor 1 FGF1 0.0028
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0028
2112 Toll-like receptor 9 TLR9 0.0028
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0028
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0028
716 5-hydroxytryptamine 7 receptor HTR7 0.0028
1178 Adenosine A2a receptor ADORA2A 0.0028
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
239 Coagulation factor X F10 0.0028
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0027
5126 Arginase rocF 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0027
2300 Lysozyme E 0.0027
3633 Lysozyme R 0.0027
5597 Lysozyme 17 0.0027
867 Penicillin-binding protein 3 pbpC 0.0027
6119 Penicillin-binding protein 3 pbp3 0.0027
7154 Penicillin-binding protein 3 pbp3 0.0027
7157 Penicillin-binding protein 3 LMHCC_2184 0.0027
7162 Penicillin-binding protein 3 pbpB 0.0027
7172 Penicillin-binding protein 3 pbp3 0.0027
165 FL cytokine receptor FLT3 0.0027
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0027
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0027
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0027
2554 Peptidyl-prolyl cis-trans isomerase, mitochondrial PPIF 0.0027
1654 Interleukin-1 beta IL1B 0.0026
818 50S ribosomal protein L10 rplJ 0.0026
427 Substance-P receptor TACR1 0.0026
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0026
2795 Methionine aminopeptidase 2 METAP2 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
461 Glycine receptor subunit alpha-3 GLRA3 0.0025
6432 Transporter snf 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0025
6174 50S ribosomal protein L32 rpmF 0.0025
4116 Dihydropteroate synthetase Not Available 0.0025
1714 Mitogen-activated protein kinase 3 MAPK3 0.0025
267 Plasminogen activator inhibitor 1 SERPINE1 0.0025
357 Carbonic anhydrase 2 CA2 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0024
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0024
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0024
6231 Pepsin A PGA3 0.0024
6 Coagulation factor XIII A chain F13A1 0.0024
2599 Tyrosine-protein kinase HCK HCK 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
1507 Cytochrome c CYCS 0.0023
5816 Cadherin-5 CDH5 0.0023
6824 Tyrosine-protein kinase Lyn LYN 0.0023
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0023
6221 Steroid hormone receptor ERR1 ESRRA 0.0023
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
94 5-hydroxytryptamine 4 receptor HTR4 0.0022
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0022
4057 Glycine N-acyltransferase GLYAT 0.0022
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0022
4056 N-arachidonyl glycine receptor GPR18 0.0022
4061 Peroxisomal sarcosine oxidase PIPOX 0.0022
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0022
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0022
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0022
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0022
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0022
3086 Plasmepsin-2 Not Available 0.0022
1466 Glycyl-tRNA synthetase GARS 0.0022
1648 Elastin ELN 0.0022
494 Caspase-1 CASP1 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
1262 Corticotropin-lipotropin POMC 0.0021
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0021
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0021
4226 Uridine phosphorylase 2 UPP2 0.0021
921 Glutamate receptor 2 GRIA2 0.0021
208 DNA-directed RNA polymerase beta' chain rpoC 0.0021
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0021
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0021
528 5-hydroxytryptamine 1E receptor HTR1E 0.002
823 Fibroblast growth factor receptor 2 FGFR2 0.002
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.002
4311 tRNA TRDMT1 0.002
4325 tRNA trmD 0.002
4328 tRNA trmD 0.002
6755 Poliovirus receptor PVR 0.002
4225 Uridine phosphorylase 1 UPP1 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
1039 Histone deacetylase 9 HDAC9 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
2958 Probable tautomerase ydcE pptA 0.0019
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
16 Adenosine A1 receptor ADORA1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
2077 Caspase-3 CASP3 0.0018
518 Peroxidase/catalase T katG 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
605 Fumarate reductase flavoprotein subunit frdA 0.0018
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0018
3673 Fumarate reductase flavoprotein subunit fccA 0.0018
4912 Fumarate reductase flavoprotein subunit ifcA 0.0018
6549 Fumarate reductase flavoprotein subunit frdA 0.0018
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0017
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0017
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0017
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0017
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0017
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0017
62 Glycine receptor subunit beta GLRB 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
383 Glycine amidinotransferase, mitochondrial GATM 0.0016
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0016
4192 DNA topoisomerase 2-beta TOP2B 0.0016
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
411 Glycine N-methyltransferase GNMT 0.0016
2216 Fibroblast growth factor receptor 4 FGFR4 0.0016
2297 Genome polyprotein Not Available 0.0016
2322 Genome polyprotein Not Available 0.0016
2694 Genome polyprotein Not Available 0.0016
2719 Genome polyprotein Not Available 0.0016
2860 Genome polyprotein Not Available 0.0016
2928 Genome polyprotein Not Available 0.0016
3160 Genome polyprotein Not Available 0.0016
3260 Genome polyprotein Not Available 0.0016
4783 Genome polyprotein Not Available 0.0016
5726 Genome polyprotein Not Available 0.0016
5779 Genome polyprotein Not Available 0.0016
5867 Genome polyprotein Not Available 0.0016
6253 Genome polyprotein Not Available 0.0016
6301 Genome polyprotein Not Available 0.0016
6380 Genome polyprotein Not Available 0.0016
6381 Genome polyprotein Not Available 0.0016
6437 Genome polyprotein Not Available 0.0016
6520 Genome polyprotein Not Available 0.0016
6521 Genome polyprotein Not Available 0.0016
6652 Genome polyprotein Not Available 0.0016
6734 Genome polyprotein Not Available 0.0016
6735 Genome polyprotein Not Available 0.0016
6736 Genome polyprotein Not Available 0.0016
6737 Genome polyprotein Not Available 0.0016
6738 Genome polyprotein Not Available 0.0016
6739 Genome polyprotein Not Available 0.0016
6744 Genome polyprotein Not Available 0.0016
6748 Genome polyprotein Not Available 0.0016
6894 Genome polyprotein Not Available 0.0016
6898 Genome polyprotein Not Available 0.0016
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0016
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0016
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0015
814 Ryanodine receptor 1 RYR1 0.0015
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0015
3884 SHMT2 protein SHMT2 0.0015
3901 SHMT2 protein SHMT2 0.0015
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0015
3879 Serine hydroxymethyltransferase 2 Not Available 0.0015
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0015
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0015
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0015
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0015
702 UMP-CMP kinase CMPK1 0.0015
936 Ephrin type-A receptor 2 EPHA2 0.0015
3639 Thymidine phosphorylase deoA 0.0015
3936 Thymidine phosphorylase TYMP 0.0015
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0015
3957 Adenosine deaminase ADA 0.0015
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0015
1196 Complement decay-accelerating factor CD55 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
174 Sigma 1-type opioid receptor SIGMAR1 0.0014
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0014
2693 Heat-labile enterotoxin B chain eltB 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
6048 Troponin C, skeletal muscle TNNC2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
908 Glutathione S-transferase theta-1 GSTT1 0.0014
233 Potassium channel subfamily K member 2 KCNK2 0.0014
1256 5-hydroxytryptamine 6 receptor HTR6 0.0014
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0014
1864 RET proto-oncogene RET 0.0014
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0014
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0014
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0014
3937 Fatty-acid amide hydrolase FAAH 0.0014
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0014
634 Squalene monooxygenase SQLE 0.0013
7196 Squalene monooxygenase ERG1 0.0013
2808 Chloramphenicol acetyltransferase 3 cat3 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
6146 High affinity copper uptake protein 1 SLC31A1 0.0013
4773 Deoxycytidine kinase DCK 0.0012
5798 Mitogen-activated protein kinase 11 MAPK11 0.0012
822 Aldose reductase AKR1B1 0.0012
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0012
694 Matrix protein 2 M 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
3808 Dihydropteroate synthase 2 folP2 0.0012
3601 Dihydropteroate synthase 1 folP1 0.0012
3807 Dihydropteroate synthase 1 folP1 0.0012
2417 Chloramphenicol acetyltransferase cat 0.0012
3278 Chloramphenicol acetyltransferase cat 0.0012
6859 Protein S100-A4 S100A4 0.0012
2810 Dr hemagglutinin structural subunit draA 0.0012
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0012
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0011
581 Cytochrome P450 2R1 CYP2R1 0.0011
3913 Glutamic acid decarboxylase GAD65 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
131 Synaptic vesicular amine transporter SLC18A2 0.0011
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0011
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0011
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0011
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0011
664 Glutamate decarboxylase 2 GAD2 0.0011
3890 Glutamate decarboxylase 2 GAD2 0.0011
4026 Aspartyl aminopeptidase DNPEP 0.0011
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0011
1912 Excitatory amino acid transporter 1 SLC1A3 0.0011
4016 Excitatory amino acid transporter 5 SLC1A7 0.0011
4019 Excitatory amino acid transporter 4 SLC1A6 0.0011
4017 5-oxoprolinase OPLAH 0.0011
1047 Excitatory amino acid transporter 2 SLC1A2 0.0011
926 Metabotropic glutamate receptor 7 GRM7 0.0011
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0011
4018 Glutamate receptor delta-2 subunit GRID2 0.0011
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0011
922 Glutamate receptor 4 GRIA4 0.0011
927 Metabotropic glutamate receptor 8 GRM8 0.0011
925 Metabotropic glutamate receptor 4 GRM4 0.0011
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0011
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0011
4020 Glutamyl aminopeptidase ENPEP 0.0011
4027 Glutamate receptor delta-1 subunit GRID1 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
106 Cannabinoid receptor 2 CNR2 0.001
1483 Membrane copper amine oxidase AOC3 0.001
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.001
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
215 Sodium channel protein type 11 subunit alpha SCN11A 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
723 Cytosolic phospholipase A2 PLA2G4A 0.001
68 Cannabinoid receptor 1 CNR1 0.001
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0009
625 Glutamate carboxypeptidase 2 FOLH1 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
54 Prothrombin F2 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
665 Phosphoserine aminotransferase PSAT1 0.0008
4652 Phosphoserine aminotransferase serC 0.0008
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0008
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0008
420 Glutamate decarboxylase 1 GAD1 0.0008
3900 Glutamate decarboxylase 1 GAD1 0.0008
719 Retinoic acid receptor responder protein 1 RARRES1 0.0008
770 Retinoic acid-induced protein 3 GPRC5A 0.0008
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
268 Adenosine A2b receptor ADORA2B 0.0008
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
916 Metabotropic glutamate receptor 1 GRM1 0.0008
856 Vitamin D3 receptor VDR 0.0008
295 Carbonic anhydrase 1 CA1 0.0008
923 Glutamate receptor 3 GRIA3 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
3221 Cytochrome c4 cc4 0.0008
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0008
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0008
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
569 Retinal dehydrogenase 2 ALDH1A2 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
611 Retinal dehydrogenase 1 ALDH1A1 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
164 Histamine H4 receptor HRH4 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
4943 Cytochrome c6 petJ 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4916 Cyanoglobin glbN 0.0005
5000 HemO hemO 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4961 Hemophore HasA hasA 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4984 Neuroglobin NGB 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4909 CooA protein cooA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4910 Cytoglobin CYGB 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4972 P450cin cinA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0005
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0005
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5961 Insulin INS 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6524 Protein tonB tonB 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4948 Cytochrome c-553 Not Available 0.0004
4923 Cytochrome c3 DvMF_2499 0.0004
4945 Cytochrome c3 Not Available 0.0004
4949 Cytochrome c3 DVU_3171 0.0004
4968 Cytochrome c3 cytc3 0.0004
4997 Cytochrome c3 SO_2727 0.0004
5219 Cytochrome c3 cyd 0.0004
4902 Nine-heme cytochrome c Ddes_2038 0.0004
3189 High-molecular-weight cytochrome c hmcA 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
3127 Nitrite reductase nirS 0.0003
3284 Nitrite reductase nirS 0.0003
292 Activin receptor type-1 ACVR1 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
693 Hemoglobin subunit beta HBB 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
661 ADP/ATP translocase 1 SLC25A4 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
6021 Adenosine kinase ADK 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
2298 Cytochrome P450-cam camC 0.0002
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