DT-Web

DB03256 - 5-Formyl-5,6,7,8-Tetrahydrofolate


Identification
Name 5-Formyl-5,6,7,8-Tetrahydrofolate
Accession Number DB03256 (EXPT01470)
Type small molecule
Description The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists which block the conversion of folic acid to folinic acid. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 473.4393
Groups experimental
Monoisotopic Weight 473.165896125
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


N,N-dimethylglycine oxidase
Name N,N-dimethylglycine oxidase
Gene Name dmg
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.924
Serine hydroxymethyltransferase
Name Serine hydroxymethyltransferase
Gene Name glyA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0789
Aminomethyltransferase
Name Aminomethyltransferase
Gene Name gcvT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1632
Bifunctional polymyxin resistance protein arnA
Name Bifunctional polymyxin resistance protein arnA
Gene Name arnA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0118
Formimidoyltransferase-cyclodeaminase
Name Formimidoyltransferase-cyclodeaminase
Gene Name FTCD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6676

Predictions


Id Partner name Gene Name Score
3342 Serine hydroxymethyltransferase glyA 1.0789
6839 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial PDK3 0.213
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.1741
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.1705
3529 Interferon-stimulated gene 20 kDa protein ISG20 0.0979
3056 Orotidine 5'-phosphate decarboxylase pyrF 0.0978
3564 Orotidine 5'-phosphate decarboxylase pyrF 0.0978
3575 Uracil phosphoribosyltransferase upp 0.0978
3600 Uracil phosphoribosyltransferase upp 0.0978
2344 Ribosomal small subunit pseudouridine synthase A rsuA 0.0852
3706 Ribosomal small subunit pseudouridine synthase A rsuA 0.0852
2966 PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase pyrR 0.0785
2590 Galactose-1-phosphate uridylyltransferase galT 0.0785
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0639
24 Thymidylate synthase TMP1 0.0594
359 Thymidylate synthase TYMS 0.0594
2626 Thymidylate synthase thyA 0.0594
2729 Thymidylate synthase thyA 0.0594
5352 Thymidylate synthase THYA 0.0594
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0244
59 AMT protein AMT 0.0243
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0243
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0243
3884 SHMT2 protein SHMT2 0.0217
3901 SHMT2 protein SHMT2 0.0217
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0217
3879 Serine hydroxymethyltransferase 2 Not Available 0.0217
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0217
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0188
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0185
13 Aminomethyltransferase, mitochondrial AMT 0.0179
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0158
809 Methionine synthase MTR 0.0151
2935 Methionine synthase metH 0.0151
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0142
3917 Methylenetetrahydrofolate reductase MTHFR 0.0128
5122 Mersacidin decarboxylase mrsD 0.0122
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0122
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0122
5095 Putidaredoxin reductase camA 0.0122
3763 5,10-methylenetetrahydrofolate reductase metF 0.0122
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0122
5094 5,10-methylenetetrahydrofolate reductase metF 0.0122
5109 Outer membrane protein p64k or PM-6 m-6 0.0122
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0122
526 Thioredoxin reductase trxB 0.0122
3767 Thioredoxin reductase trxB 0.0122
5078 Amine oxidase, flavin-containing PSPTO1126 0.0122
5111 Phenylacetone monooxygenase pamO 0.0122
1410 Oxidoreductase HSD17B6 0.0122
4725 Oxidoreductase Not Available 0.0122
5124 Oxidoreductase Not Available 0.0122
5115 FkbI fkbI 0.0122
3133 UDP-galactopyranose mutase glf 0.0122
5099 UDP-galactopyranose mutase glf 0.0122
5083 Cryptochrome DASH cry 0.0122
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0122
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0122
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0122
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0122
5081 L-aspartate oxidase nadB 0.0122
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0122
4486 Phenol 2-hydroxylase component B pheA2 0.0106
3594 Deoxyribodipyrimidine photo-lyase phr 0.0106
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0106
5080 Deoxyribodipyrimidine photo-lyase phr 0.0106
2526 NADPH-ferredoxin reductase fprA fprA 0.0106
4477 Dihydrolipoyl dehydrogenase lpdV 0.0106
5077 Dihydrolipoyl dehydrogenase Not Available 0.0106
5117 Dihydrolipoyl dehydrogenase lpd 0.0106
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0106
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0106
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0106
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0106
4439 Ferredoxin reductase bphA4 0.0106
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0106
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0106
5073 Ferredoxin--NADP reductase petH 0.0106
5076 Ferredoxin--NADP reductase fpr 0.0106
5119 Ferredoxin--NADP reductase petH 0.0106
5121 Ferredoxin--NADP reductase fpr 0.0106
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0106
2268 Cholesterol oxidase choB 0.0106
2822 Cholesterol oxidase choA 0.0106
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0106
2470 Pyruvate oxidase pox5 0.0106
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0106
665 Phosphoserine aminotransferase PSAT1 0.0099
4652 Phosphoserine aminotransferase serC 0.0099
420 Glutamate decarboxylase 1 GAD1 0.0099
3900 Glutamate decarboxylase 1 GAD1 0.0099
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0099
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0099
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0098
2893 Glycine oxidase thiO 0.0098
3102 Flavohemoprotein hmp 0.0098
4969 Flavohemoprotein hmp 0.0098
4440 NADH peroxidase npr 0.0098
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0098
2567 Thymidylate synthase thyX thyX 0.0093
2823 Trypanothione reductase TPR 0.0093
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0093
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0089
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0089
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0089
3877 Growth-inhibiting protein 18 GIG18 0.0089
2769 P-hydroxybenzoate hydroxylase pobA 0.0089
2809 P-hydroxybenzoate hydroxylase pobA 0.0089
426 Aspartate aminotransferase, mitochondrial GOT2 0.0086
2380 Monomeric sarcosine oxidase soxA 0.0085
327 Glutathione reductase gor 0.0085
5110 Glutathione reductase GR2 0.0085
126 D-lactate dehydrogenase dld 0.0085
3545 D-lactate dehydrogenase Not Available 0.0085
4510 D-lactate dehydrogenase ldhA 0.0085
605 Fumarate reductase flavoprotein subunit frdA 0.0084
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0084
3673 Fumarate reductase flavoprotein subunit fccA 0.0084
4912 Fumarate reductase flavoprotein subunit ifcA 0.0084
6549 Fumarate reductase flavoprotein subunit frdA 0.0084
763 Tyrosine aminotransferase TAT 0.0083
5493 Tyrosine aminotransferase Not Available 0.0083
3904 Alanine aminotransferase 2 GPT2 0.0083
735 Alanine aminotransferase 1 GPT 0.0083
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0081
6645 D-amino-acid oxidase DAO 0.0081
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.008
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0079
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0077
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0074
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0073
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.007
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0065
714 Glutathione reductase, mitochondrial GSR 0.0065
76 Nitric-oxide synthase, brain NOS1 0.0062
4026 Aspartyl aminopeptidase DNPEP 0.0059
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0059
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0059
4027 Glutamate receptor delta-1 subunit GRID1 0.0059
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0059
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0059
1912 Excitatory amino acid transporter 1 SLC1A3 0.0059
927 Metabotropic glutamate receptor 8 GRM8 0.0059
4016 Excitatory amino acid transporter 5 SLC1A7 0.0059
925 Metabotropic glutamate receptor 4 GRM4 0.0059
926 Metabotropic glutamate receptor 7 GRM7 0.0059
4019 Excitatory amino acid transporter 4 SLC1A6 0.0059
1047 Excitatory amino acid transporter 2 SLC1A2 0.0059
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0059
664 Glutamate decarboxylase 2 GAD2 0.0059
3890 Glutamate decarboxylase 2 GAD2 0.0059
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0059
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0059
922 Glutamate receptor 4 GRIA4 0.0059
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0059
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0059
4020 Glutamyl aminopeptidase ENPEP 0.0059
4018 Glutamate receptor delta-2 subunit GRID2 0.0059
4017 5-oxoprolinase OPLAH 0.0059
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0058
3887 Phosphorylase PYGB 0.0055
3911 Uncharacterized protein C20orf38 SPTLC3 0.0055
3881 Selenocysteine lyase variant Not Available 0.0055
3906 Serine dehydratase-like SDSL 0.0055
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0055
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0055
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0055
3878 GAD1 protein GAD1 0.0055
3883 Ornithine aminotransferase variant Not Available 0.0055
306 Pyridoxal phosphate phosphatase PDXP 0.0055
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0055
3891 Putative L-Dopa decarboxylase DDC 0.0055
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0055
3893 DDC protein DDC 0.0055
3880 Serine hydroxymethyltransferase 1 Not Available 0.0055
3886 Migration-inducing protein 4 ALAS1 0.0055
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0055
3894 KIAA0251 protein PDXDC1 0.0055
3875 Glycogen phosphorylase, brain form PYGB 0.0055
3882 Brain glycogen phosphorylase variant Not Available 0.0055
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0055
3905 Molybdenum cofactor sulfurase MOCOS 0.0055
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0055
4120 NADPH--cytochrome P450 reductase POR 0.0055
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.005
625 Glutamate carboxypeptidase 2 FOLH1 0.0049
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0049
5 Glutaminase liver isoform, mitochondrial GLS2 0.0049
917 Glutaminase kidney isoform, mitochondrial GLS 0.0049
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0049
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0049
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0049
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0049
5261 Phosphoribosylformylglycinamidine synthase purL 0.0049
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0049
3939 Amine oxidase [flavin-containing] B MAOB 0.0048
534 Threonine synthase-like 1 THNSL1 0.0047
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0047
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0047
431 Serine racemase SRR 0.0047
727 Serine palmitoyltransferase 2 SPTLC2 0.0047
184 L-serine dehydratase SDS 0.0047
491 Serine palmitoyltransferase 1 SPTLC1 0.0047
89 Cysteine sulfinic acid decarboxylase CSAD 0.0047
3 Histidine decarboxylase HDC 0.0047
499 Arginine decarboxylase ADC 0.0047
3947 Xanthine dehydrogenase/oxidase XDH 0.0046
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0046
3913 Glutamic acid decarboxylase GAD65 0.0046
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0046
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0046
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0046
916 Metabotropic glutamate receptor 1 GRM1 0.0045
435 Kynureninase KYNU 0.0045
4654 Kynureninase kynU 0.0045
923 Glutamate receptor 3 GRIA3 0.0044
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0044
1671 Excitatory amino acid transporter 3 SLC1A1 0.0043
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0043
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0043
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0043
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0043
3941 Amine oxidase [flavin-containing] A MAOA 0.0043
169 Cysteine desulfurase, mitochondrial NFS1 0.0043
472 Ornithine aminotransferase, mitochondrial OAT 0.0043
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0042
358 Cystathionine beta-synthase CBS 0.0042
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0041
868 Cystathionine gamma-lyase CTH 0.0041
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0039
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0039
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0039
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0038
449 Ornithine decarboxylase ODC1 0.0037
349 Serine--pyruvate aminotransferase AGXT 0.0037
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
705 Glutamate receptor 1 GRIA1 0.0036
33 Cystine/glutamate transporter SLC7A11 0.0036
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0035
3426 Glutamine synthetase glnA 0.0035
3987 Glutamine synthetase GLUL 0.0035
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0034
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0034
10 Glycogen phosphorylase, liver form PYGL 0.0033
738 Monocarboxylate transporter 1 SLC16A1 0.0029
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0028
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0027
6151 Monocarboxylate transporter 10 SLC16A10 0.0027
921 Glutamate receptor 2 GRIA2 0.0026
1152 Glycogen phosphorylase, muscle form PYGM 0.0025
↑