DT-Web

DB02067 - Triglu-5-Formyl-Tetrahydrofolate


Identification
Name Triglu-5-Formyl-Tetrahydrofolate
Accession Number DB02067 (EXPT03045)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 731.6673
Groups experimental
Monoisotopic Weight 731.251082315
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Serine hydroxymethyltransferase, cytosolic
Name Serine hydroxymethyltransferase, cytosolic
Gene Name SHMT1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4958

Predictions


Id Partner name Gene Name Score
3470 Hypothetical protein MG245 homolog MPN_348 0.1428
1649 Small inducible cytokine A2 CCL2 0.069
3193 Serine hydroxymethyltransferase glyA 0.0652
3342 Serine hydroxymethyltransferase glyA 0.0652
4823 L-allo-threonine aldolase TM_1744 0.0594
279 Tyrosinase TYR 0.0592
449 Ornithine decarboxylase ODC1 0.0481
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0209
3879 Serine hydroxymethyltransferase 2 Not Available 0.0209
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0209
3884 SHMT2 protein SHMT2 0.0206
3901 SHMT2 protein SHMT2 0.0206
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0141
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0141
3763 5,10-methylenetetrahydrofolate reductase metF 0.0141
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0141
5094 5,10-methylenetetrahydrofolate reductase metF 0.0141
59 AMT protein AMT 0.0141
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0141
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0134
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0112
13 Aminomethyltransferase, mitochondrial AMT 0.0111
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0103
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0094
809 Methionine synthase MTR 0.0094
2935 Methionine synthase metH 0.0094
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0093
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0093
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0093
3917 Methylenetetrahydrofolate reductase MTHFR 0.008
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0078
349 Serine--pyruvate aminotransferase AGXT 0.0077
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0071
4057 Glycine N-acyltransferase GLYAT 0.0071
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0071
1466 Glycyl-tRNA synthetase GARS 0.0071
4056 N-arachidonyl glycine receptor GPR18 0.0071
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0071
4061 Peroxisomal sarcosine oxidase PIPOX 0.0071
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0071
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0071
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0071
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0071
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0063
62 Glycine receptor subunit beta GLRB 0.0057
411 Glycine N-methyltransferase GNMT 0.0057
383 Glycine amidinotransferase, mitochondrial GATM 0.0055
207 Glutathione synthetase GSS 0.0055
5269 Glutathione synthetase gshB 0.0055
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0052
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.005
593 Proton-coupled amino acid transporter 1 SLC36A1 0.005
461 Glycine receptor subunit alpha-3 GLRA3 0.0048
820 Glycine receptor subunit alpha-2 GLRA2 0.0048
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0047
3880 Serine hydroxymethyltransferase 1 Not Available 0.0044
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0044
482 Glycine receptor subunit alpha-1 GLRA1 0.0042
3911 Uncharacterized protein C20orf38 SPTLC3 0.0036
306 Pyridoxal phosphate phosphatase PDXP 0.0036
3881 Selenocysteine lyase variant Not Available 0.0036
3887 Phosphorylase PYGB 0.0036
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0036
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0036
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0036
3883 Ornithine aminotransferase variant Not Available 0.0036
3906 Serine dehydratase-like SDSL 0.0036
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0036
3891 Putative L-Dopa decarboxylase DDC 0.0036
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0036
664 Glutamate decarboxylase 2 GAD2 0.0036
3890 Glutamate decarboxylase 2 GAD2 0.0036
3886 Migration-inducing protein 4 ALAS1 0.0036
3878 GAD1 protein GAD1 0.0036
3893 DDC protein DDC 0.0036
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0036
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0036
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0036
3894 KIAA0251 protein PDXDC1 0.0036
3875 Glycogen phosphorylase, brain form PYGB 0.0036
3882 Brain glycogen phosphorylase variant Not Available 0.0036
3905 Molybdenum cofactor sulfurase MOCOS 0.0036
6151 Monocarboxylate transporter 10 SLC16A10 0.0036
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.003
184 L-serine dehydratase SDS 0.003
431 Serine racemase SRR 0.003
491 Serine palmitoyltransferase 1 SPTLC1 0.003
89 Cysteine sulfinic acid decarboxylase CSAD 0.003
727 Serine palmitoyltransferase 2 SPTLC2 0.003
534 Threonine synthase-like 1 THNSL1 0.003
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.003
665 Phosphoserine aminotransferase PSAT1 0.003
4652 Phosphoserine aminotransferase serC 0.003
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.003
420 Glutamate decarboxylase 1 GAD1 0.003
3900 Glutamate decarboxylase 1 GAD1 0.003
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.003
3 Histidine decarboxylase HDC 0.003
499 Arginine decarboxylase ADC 0.003
435 Kynureninase KYNU 0.003
4654 Kynureninase kynU 0.003
3913 Glutamic acid decarboxylase GAD65 0.003
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0029
472 Ornithine aminotransferase, mitochondrial OAT 0.0028
169 Cysteine desulfurase, mitochondrial NFS1 0.0028
868 Cystathionine gamma-lyase CTH 0.0028
3877 Growth-inhibiting protein 18 GIG18 0.0027
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0027
426 Aspartate aminotransferase, mitochondrial GOT2 0.0027
358 Cystathionine beta-synthase CBS 0.0027
735 Alanine aminotransferase 1 GPT 0.0026
3904 Alanine aminotransferase 2 GPT2 0.0026
763 Tyrosine aminotransferase TAT 0.0026
5493 Tyrosine aminotransferase Not Available 0.0026
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0025
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0025
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0023
10 Glycogen phosphorylase, liver form PYGL 0.0023
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0022
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0022
1152 Glycogen phosphorylase, muscle form PYGM 0.0018
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