DT-Web

DB08794 - Ethyl biscoumacetate


Identification
Name Ethyl biscoumacetate
Accession Number DB08794
Type small molecule
Description Ethyl biscoumacetate is a courmarin that is used as an anticoagulant. It has actions similar to those of Warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 408.3576
Groups Not Available
Monoisotopic Weight 408.084517488
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Enzymes


Glutamine synthetase
Name Glutamine synthetase
Gene Name GLUL
Actions inhibitor
References
  • Sharaev PN, Bogdanov NG, Sarycheva IK, Zhukova EE: [Allosteric regulation of glucosamine synthetase activity by naphthoquinone derivatives and ethyl ester of di-(4-oxycumarinyl-3)-acetic acid]. Biokhimiia. 1981 Feb;46(2):342-6. - Pubmed
DTHybrid score 0.3184

Predictions


Id Partner name Gene Name Score
3426 Glutamine synthetase glnA 0.3184
85 Growth hormone receptor GHR 0.0319
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.028
461 Glycine receptor subunit alpha-3 GLRA3 0.0246
820 Glycine receptor subunit alpha-2 GLRA2 0.0246
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0209
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0188
466 Solute carrier family 12 member 3 SLC12A3 0.0184
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0178
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0172
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0165
468 Cytochrome P450 4A11 CYP4A11 0.0152
23 D(1A) dopamine receptor DRD1 0.0151
295 Carbonic anhydrase 1 CA1 0.0149
318 Alpha-2A adrenergic receptor ADRA2A 0.0146
159 Penicillin-binding protein 2B penA 0.0143
6121 Penicillin-binding protein 2B penA 0.0143
502 5-hydroxytryptamine 2A receptor HTR2A 0.0142
556 Alpha-1A adrenergic receptor ADRA1A 0.0137
317 Methionine-R-sulfoxide reductase SEPX1 0.0135
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0135
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0134
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0134
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0134
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0134
6024 Cytochrome P450 1A1 CYP1A1 0.0132
6106 Cytochrome P450 2C18 CYP2C18 0.0126
1024 Solute carrier family 22 member 11 SLC22A11 0.0121
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0119
6151 Monocarboxylate transporter 10 SLC16A10 0.0119
357 Carbonic anhydrase 2 CA2 0.0116
191 Peptide methionine sulfoxide reductase MSRA 0.0114
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0114
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0112
3923 Cholinesterase BCHE 0.0108
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0108
6142 Solute carrier family 22 member 8 SLC22A8 0.0105
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0103
840 Methionine synthase reductase, mitochondrial MTRR 0.01
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0098
5 Glutaminase liver isoform, mitochondrial GLS2 0.0098
917 Glutaminase kidney isoform, mitochondrial GLS 0.0098
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0098
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0098
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0098
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0098
5261 Phosphoribosylformylglycinamidine synthase purL 0.0098
1729 Solute carrier family 22 member 6 SLC22A6 0.0096
809 Methionine synthase MTR 0.0094
2935 Methionine synthase metH 0.0094
587 Serum albumin ALB 0.0094
6016 Cytochrome P450 2C19 CYP2C19 0.0084
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0083
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0083
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0083
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0083
1008 CTP synthase 1 CTPS 0.0083
3989 Glutaminyl-tRNA synthetase QARS 0.0083
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0083
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0083
3917 Methylenetetrahydrofolate reductase MTHFR 0.0079
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0078
2795 Methionine aminopeptidase 2 METAP2 0.0075
263 Neutral amino acid transporter B(0) SLC1A5 0.007
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.007
4512 Cytochrome P450 3A4 CYP3A4 0.007
413 Amidophosphoribosyltransferase PPAT 0.0068
2515 Amidophosphoribosyltransferase purF 0.0068
3714 Amidophosphoribosyltransferase purF 0.0068
6 Coagulation factor XIII A chain F13A1 0.0066
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0065
314 System N amino acid transporter 1 SLC38A3 0.0064
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0059
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0058
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0056
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.003
4026 Aspartyl aminopeptidase DNPEP 0.003
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.003
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.003
1047 Excitatory amino acid transporter 2 SLC1A2 0.003
926 Metabotropic glutamate receptor 7 GRM7 0.003
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.003
4016 Excitatory amino acid transporter 5 SLC1A7 0.003
4019 Excitatory amino acid transporter 4 SLC1A6 0.003
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.003
1912 Excitatory amino acid transporter 1 SLC1A3 0.003
927 Metabotropic glutamate receptor 8 GRM8 0.003
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.003
4017 5-oxoprolinase OPLAH 0.003
922 Glutamate receptor 4 GRIA4 0.003
925 Metabotropic glutamate receptor 4 GRM4 0.003
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.003
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.003
4020 Glutamyl aminopeptidase ENPEP 0.003
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.003
4018 Glutamate receptor delta-2 subunit GRID2 0.003
4027 Glutamate receptor delta-1 subunit GRID1 0.003
664 Glutamate decarboxylase 2 GAD2 0.003
3890 Glutamate decarboxylase 2 GAD2 0.003
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0026
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0026
625 Glutamate carboxypeptidase 2 FOLH1 0.0025
665 Phosphoserine aminotransferase PSAT1 0.0025
4652 Phosphoserine aminotransferase serC 0.0025
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0025
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0025
420 Glutamate decarboxylase 1 GAD1 0.0025
3900 Glutamate decarboxylase 1 GAD1 0.0025
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0025
916 Metabotropic glutamate receptor 1 GRM1 0.0024
1671 Excitatory amino acid transporter 3 SLC1A1 0.0023
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0023
3877 Growth-inhibiting protein 18 GIG18 0.0023
923 Glutamate receptor 3 GRIA3 0.0023
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0023
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0023
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0022
763 Tyrosine aminotransferase TAT 0.0022
5493 Tyrosine aminotransferase Not Available 0.0022
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0022
426 Aspartate aminotransferase, mitochondrial GOT2 0.0022
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0022
735 Alanine aminotransferase 1 GPT 0.0022
3904 Alanine aminotransferase 2 GPT2 0.0022
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0021
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0021
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0021
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.002
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.002
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.002
705 Glutamate receptor 1 GRIA1 0.002
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0019
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0019
33 Cystine/glutamate transporter SLC7A11 0.0019
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0019
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0019
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0015
738 Monocarboxylate transporter 1 SLC16A1 0.0015
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0015
921 Glutamate receptor 2 GRIA2 0.0014
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