DT-Web

DB02209 - Pyridoxine-5'-Phosphate


Identification
Name Pyridoxine-5'-Phosphate
Accession Number DB02209 (EXPT02710)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 249.1577
Groups experimental
Monoisotopic Weight 249.040223633
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Pyridoxine 5'-phosphate synthase
Name Pyridoxine 5'-phosphate synthase
Gene Name pdxJ
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score Not Available
Ornithine decarboxylase
Name Ornithine decarboxylase
Gene Name ODC1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9327

Enzymes


Pyridoxine-5'-phosphate oxidase
Name Pyridoxine-5'-phosphate oxidase
Gene Name PNPO
Actions Not Available
References
  • Hwang IK, Yoo KY, Kim do H, Lee BH, Kwon YG, Won MH: Time course of changes in pyridoxal 5'-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage. Exp Neurol. 2007 Jul;206(1):114-25. Epub 2007 Apr 24. - Pubmed
  • Kim SY, An JJ, Kim DW, Choi SH, Lee SH, Hwang SI, Kwon OS, Kang TC, Won MH, Cho SW, Park J, Eum WS, Lee KS, Choi SY: Tat-mediated protein transduction of human brain pyridoxine-5-P oxidase into PC12 cells. J Biochem Mol Biol. 2006 Jan 31;39(1):76-83. - Pubmed
  • Kim DW, Eum WS, Choi HS, Kim SY, An JJ, Lee SH, Sohn EJ, Hwang SI, Kwon OS, Kang TC, Won MH, Cho SW, Lee KS, Park J, Choi SY: Human brain pyridoxal-5'-phosphate phosphatase: production and characterization of monoclonal antibodies. J Biochem Mol Biol. 2005 Nov 30;38(6):703-8. - Pubmed
  • Nagahashi Y, Tazoe M, Hoshino T: Cloning of the pyridoxine 5'-phosphate phosphatase gene (pdxP) and vitamin B6 production in pdxP recombinant Sinorhizobium meliloti. Biosci Biotechnol Biochem. 2008 Feb;72(2):421-7. Epub 2008 Feb 7. - Pubmed
DTHybrid score Not Available
Pyridoxine 5'-phosphate phosphatase
Name Pyridoxine 5'-phosphate phosphatase
Gene Name Not Available
Actions substrate
References
  • Nagahashi Y, Tazoe M, Hoshino T: Cloning of the pyridoxine 5'-phosphate phosphatase gene (pdxP) and vitamin B6 production in pdxP recombinant Sinorhizobium meliloti. Biosci Biotechnol Biochem. 2008 Feb;72(2):421-7. Epub 2008 Feb 7. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.2681
1750 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 PFKFB1 0.1709
2314 Triosephosphate isomerase TPI 0.1649
3417 Triosephosphate isomerase tpiA 0.1649
3443 Triosephosphate isomerase tpiA 0.1649
6346 Triosephosphate isomerase TPI1 0.1649
4823 L-allo-threonine aldolase TM_1744 0.0823
2429 Putrescine-binding periplasmic protein potF 0.0732
3193 Serine hydroxymethyltransferase glyA 0.0645
3342 Serine hydroxymethyltransferase glyA 0.0645
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0639
5226 Protein ninB ninB 0.0631
1277 Alpha-1-antitrypsin SERPINA1 0.0549
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0511
2826 Glucose--fructose oxidoreductase gfo 0.0492
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0485
4549 Endonuclease III HP_0602 0.0482
833 Organic cation/carnitine transporter 1 SLC22A4 0.0418
1313 Lactoylglutathione lyase GLO1 0.0387
2300 Lysozyme E 0.032
3633 Lysozyme R 0.032
5597 Lysozyme 17 0.032
123 Diamine acetyltransferase 1 SAT1 0.0278
5492 Cystathionine gamma-synthase metB 0.0273
5491 Methionine gamma-lyase mdeA 0.0273
303 Diamine acetyltransferase 2 SAT2 0.027
1317 Spermine synthase SMS 0.027
623 Spermine oxidase SMOX 0.027
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0247
349 Serine--pyruvate aminotransferase AGXT 0.0216
2758 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA 0.0215
1152 Glycogen phosphorylase, muscle form PYGM 0.0171
2249 Aspartate aminotransferase aspC 0.0158
2671 Aspartate aminotransferase aspC 0.0158
5490 Aspartate aminotransferase Not Available 0.0158
3947 Xanthine dehydrogenase/oxidase XDH 0.0147
6145 Solute carrier family 22 member 1 SLC22A1 0.0113
5178 Protein nrdI nrdI 0.0097
5181 Hypothetical protein yhdA azr 0.0097
5179 Probable aromatic acid decarboxylase pad1 0.0096
5202 Nitroreductase family protein BC_1844 0.0096
5201 FMN-binding protein DvMF_2023 0.0096
3293 Flavodoxin Not Available 0.0096
4614 Flavodoxin DVU_2680 0.0096
5172 Flavodoxin isiB 0.0096
5173 Flavodoxin isiB 0.0096
5182 Flavodoxin fldA 0.0096
5198 Flavodoxin-1 fldA 0.0096
5170 Epidermin decarboxylase epiD 0.0096
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0096
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0096
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0096
5175 Hypothetical protein SMU.260 SMU_260 0.0096
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0096
5200 NADH dehydrogenase nox 0.0096
5191 Morphinone reductase morB 0.0096
5131 PhzG phzG 0.0096
5193 Phenazine biosynthesis protein phzG phzG 0.0096
4405 Nitric oxide reductase fprA 0.0096
4037 Hypothetical protein GPX1 0.0096
4297 Hypothetical protein SP_1951 0.0096
4521 Hypothetical protein BC_2969 0.0096
4540 Hypothetical protein TM_1070 0.0096
4555 Hypothetical protein MT1739 0.0096
4569 Hypothetical protein mshD 0.0096
4578 Hypothetical protein PA3270 0.0096
4747 Hypothetical protein PA3967 0.0096
5177 Hypothetical protein TM_0096 0.0096
5194 Hypothetical protein PA1204 0.0096
5240 Hypothetical protein Rv2991 0.0096
5370 Hypothetical protein TM_1158 0.0096
5710 Hypothetical protein Tb927.5.1360 0.0096
5190 Rubredoxin-oxygen oxidoreductase roo 0.0096
3911 Uncharacterized protein C20orf38 SPTLC3 0.0094
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0094
3881 Selenocysteine lyase variant Not Available 0.0094
3883 Ornithine aminotransferase variant Not Available 0.0094
306 Pyridoxal phosphate phosphatase PDXP 0.0094
3906 Serine dehydratase-like SDSL 0.0094
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0094
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0094
3891 Putative L-Dopa decarboxylase DDC 0.0094
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0094
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0094
3878 GAD1 protein GAD1 0.0094
3887 Phosphorylase PYGB 0.0094
3880 Serine hydroxymethyltransferase 1 Not Available 0.0094
3893 DDC protein DDC 0.0094
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0094
664 Glutamate decarboxylase 2 GAD2 0.0094
3890 Glutamate decarboxylase 2 GAD2 0.0094
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0094
3886 Migration-inducing protein 4 ALAS1 0.0094
3894 KIAA0251 protein PDXDC1 0.0094
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0094
3875 Glycogen phosphorylase, brain form PYGB 0.0094
3882 Brain glycogen phosphorylase variant Not Available 0.0094
3905 Molybdenum cofactor sulfurase MOCOS 0.0094
4503 NADPH-flavin oxidoreductase frp 0.0088
5189 Trimethylamine dehydrogenase tmd 0.0088
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.0088
3680 Dihydroorotate dehydrogenase A pyrDA 0.0084
4407 FMN-dependent NADH-azoreductase azoR 0.0084
5169 FMN-dependent NADH-azoreductase azoR 0.0084
5176 YtnJ moxC 0.0083
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0083
3507 Chorismate synthase aroC 0.0083
5171 Chorismate synthase aroC 0.0083
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0077
2775 Dihydroorotate dehydrogenase pyrD 0.0077
3913 Glutamic acid decarboxylase GAD65 0.0076
435 Kynureninase KYNU 0.0075
4654 Kynureninase kynU 0.0075
3 Histidine decarboxylase HDC 0.0075
472 Ornithine aminotransferase, mitochondrial OAT 0.0075
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0075
499 Arginine decarboxylase ADC 0.0075
727 Serine palmitoyltransferase 2 SPTLC2 0.0075
184 L-serine dehydratase SDS 0.0075
491 Serine palmitoyltransferase 1 SPTLC1 0.0075
431 Serine racemase SRR 0.0075
89 Cysteine sulfinic acid decarboxylase CSAD 0.0074
408 Riboflavin kinase RFK 0.0074
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0074
665 Phosphoserine aminotransferase PSAT1 0.0074
4652 Phosphoserine aminotransferase serC 0.0074
420 Glutamate decarboxylase 1 GAD1 0.0074
3900 Glutamate decarboxylase 1 GAD1 0.0074
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0074
534 Threonine synthase-like 1 THNSL1 0.0074
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0074
868 Cystathionine gamma-lyase CTH 0.0073
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0073
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0073
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0073
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0073
5180 L(+)-mandelate dehydrogenase mdlB 0.0073
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0073
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0071
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0071
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.007
426 Aspartate aminotransferase, mitochondrial GOT2 0.0068
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0068
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0067
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0067
169 Cysteine desulfurase, mitochondrial NFS1 0.0066
3884 SHMT2 protein SHMT2 0.0066
3901 SHMT2 protein SHMT2 0.0066
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0066
3879 Serine hydroxymethyltransferase 2 Not Available 0.0066
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0066
3877 Growth-inhibiting protein 18 GIG18 0.0065
4284 Pentaerythritol tetranitrate reductase onr 0.0065
358 Cystathionine beta-synthase CBS 0.0065
10 Glycogen phosphorylase, liver form PYGL 0.0064
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0064
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0062
763 Tyrosine aminotransferase TAT 0.0062
5493 Tyrosine aminotransferase Not Available 0.0062
735 Alanine aminotransferase 1 GPT 0.0062
3904 Alanine aminotransferase 2 GPT2 0.0062
6268 Hydroxyacid oxidase 1 HAO1 0.0061
654 Flavin reductase BLVRB 0.006
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.006
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0058
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0056
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0055
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0055
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0049
76 Nitric-oxide synthase, brain NOS1 0.0049
4120 NADPH--cytochrome P450 reductase POR 0.0046
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