DT-Web

DB00171 - Adenosine triphosphate


Identification
Name Adenosine triphosphate
Accession Number DB00171 (EXPT00007, NUTR00017)
Type small molecule
Description An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 507.181
Groups approved
Monoisotopic Weight 506.995745159
Pharmacology
Indication For nutritional supplementation, also for treating dietary shortage or imbalance
Mechanism of action ATP is able to store and transport chemical energy within cells. ATP also plays an important role in the synthesis of nucleic acids. ATP can be produced by various cellular processes, most typically in mitochondria by oxidative phosphorylation under the catalytic influence of ATP synthase. The total quantity of ATP in the human body is about 0.1 mole. The energy used by human cells requires the hydrolysis of 200 to 300 moles of ATP daily. This means that each ATP molecule is recycled 2000 to 3000 times during a single day. ATP cannot be stored, hence its consumption must closely follow its synthesis.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Oral LD50 in rats is > 2 g/kg.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Tyrosine-protein kinase ABL2
Name Tyrosine-protein kinase ABL2
Gene Name ABL2
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7433
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Pharmacological action unknown
Actions Not Available
References
  • Lage H: MDR1/P-glycoprotein (ABCB1) as target for RNA interference-mediated reversal of multidrug resistance. Curr Drug Targets. 2006 Jul;7(7):813-21. - Pubmed
  • Gardner ER, Burger H, van Schaik RH, van Oosterom AT, de Bruijn EA, Guetens G, Prenen H, de Jong FA, Baker SD, Bates SE, Figg WD, Verweij J, Sparreboom A, Nooter K: Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib. Clin Pharmacol Ther. 2006 Aug;80(2):192-201. - Pubmed
  • Blume H, Donath F, Warnke A, Schug BS: Pharmacokinetic drug interaction profiles of proton pump inhibitors. Drug Saf. 2006;29(9):769-84. - Pubmed
  • Gervasini G, Carrillo JA, Garcia M, San Jose C, Cabanillas A, Benitez J: Adenosine triphosphate-binding cassette B1 (ABCB1) (multidrug resistance 1) G2677T/A gene polymorphism is associated with high risk of lung cancer. Cancer. 2006 Dec 15;107(12):2850-7. - Pubmed
  • Fukui N, Suzuki Y, Sawamura K, Sugai T, Watanabe J, Inoue Y, Someya T: Dose-dependent effects of the 3435 C>T genotype of ABCB1 gene on the steady-state plasma concentration of fluvoxamine in psychiatric patients. Ther Drug Monit. 2007 Apr;29(2):185-9. - Pubmed
DTHybrid score 0.5355
ATP-binding cassette sub-family G member 1
Name ATP-binding cassette sub-family G member 1
Gene Name ABCG1
Pharmacological action unknown
Actions Not Available
References
  • Lage H: MDR1/P-glycoprotein (ABCB1) as target for RNA interference-mediated reversal of multidrug resistance. Curr Drug Targets. 2006 Jul;7(7):813-21. - Pubmed
  • Materna V, Stege A, Surowiak P, Priebsch A, Lage H: RNA interference-triggered reversal of ABCC2-dependent cisplatin resistance in human cancer cells. Biochem Biophys Res Commun. 2006 Sep 15;348(1):153-7. Epub 2006 Jul 14. - Pubmed
  • Thomas AC, Cullup T, Norgett EE, Hill T, Barton S, Dale BA, Sprecher E, Sheridan E, Taylor AE, Wilroy RS, DeLozier C, Burrows N, Goodyear H, Fleckman P, Stephens KG, Mehta L, Watson RM, Graham R, Wolf R, Slavotinek A, Martin M, Bourn D, Mein CA, O'Toole EA, Kelsell DP: ABCA12 is the major harlequin ichthyosis gene. J Invest Dermatol. 2006 Nov;126(11):2408-13. Epub 2006 Aug 10. - Pubmed
  • Girardin F: Membrane transporter proteins: a challenge for CNS drug development. Dialogues Clin Neurosci. 2006;8(3):311-21. - Pubmed
  • Pinkett HW, Lee AT, Lum P, Locher KP, Rees DC: An inward-facing conformation of a putative metal-chelate-type ABC transporter. Science. 2007 Jan 19;315(5810):373-7. Epub 2006 Dec 7. - Pubmed
DTHybrid score 0.9497
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Pharmacological action unknown
Actions Not Available
References
  • Materna V, Stege A, Surowiak P, Priebsch A, Lage H: RNA interference-triggered reversal of ABCC2-dependent cisplatin resistance in human cancer cells. Biochem Biophys Res Commun. 2006 Sep 15;348(1):153-7. Epub 2006 Jul 14. - Pubmed
  • Rau T, Erney B, Gores R, Eschenhagen T, Beck J, Langer T: High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations. Clin Pharmacol Ther. 2006 Nov;80(5):468-76. - Pubmed
  • Li GX, Pei QL, Gao Y, Liu KM, Nie JS, Han G, Qiu YL, Zhang WP: Protective effects of hepatocellular canalicular conjugate export pump (Mrp2) on sodium arsenite-induced hepatic dysfunction in rats. Exp Toxicol Pathol. 2007 Aug;58(6):447-53. Epub 2007 Apr 30. - Pubmed
DTHybrid score 0.4996
ATP-binding cassette sub-family A member 1
Name ATP-binding cassette sub-family A member 1
Gene Name ABCA1
Pharmacological action unknown
Actions Not Available
References
  • Porchay I, Pean F, Bellili N, Royer B, Cogneau J, Chesnier MC, Caradec A, Tichet J, Balkau B, Marre M, Fumeron F: ABCA1 single nucleotide polymorphisms on high-density lipoprotein-cholesterol and overweight: the D.E.S.I.R. study. Obesity (Silver Spring). 2006 Nov;14(11):1874-9. - Pubmed
  • Badeau R, Jauhiainen M, Metso J, Nikander E, Tikkanen MJ, Ylikorkala O, Mikkola TS: Effect of isolated isoflavone supplementation on ABCA1-dependent cholesterol efflux potential in postmenopausal women. Menopause. 2007 Mar-Apr;14(2):293-9. - Pubmed
  • Zarubica A, Trompier D, Chimini G: ABCA1, from pathology to membrane function. Pflugers Arch. 2007 Feb;453(5):569-79. Epub 2006 Jul 21. - Pubmed
DTHybrid score 0.9029
Acetyl-coenzyme A synthetase, cytoplasmic
Name Acetyl-coenzyme A synthetase, cytoplasmic
Gene Name ACSS2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Starai VJ, Celic I, Cole RN, Boeke JD, Escalante-Semerena JC: Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine. Science. 2002 Dec 20;298(5602):2390-2. - Pubmed
  • Schuler AJ, Jenkins D: Enhanced biological phosphorus removal from wastewater by biomass with different phosphorus contents, Part II: Anaerobic adenosine triphosphate utilization and acetate uptake rates. Water Environ Res. 2003 Nov-Dec;75(6):499-511. - Pubmed
DTHybrid score 1.0394
ALK tyrosine kinase receptor
Name ALK tyrosine kinase receptor
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9495
NEDD8-activating enzyme E1 regulatory subunit
Name NEDD8-activating enzyme E1 regulatory subunit
Gene Name NAE1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9498
5'-AMP-activated protein kinase catalytic subunit alpha-1
Name 5'-AMP-activated protein kinase catalytic subunit alpha-1
Gene Name PRKAA1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score Not Available
A-Raf proto-oncogene serine/threonine-protein kinase
Name A-Raf proto-oncogene serine/threonine-protein kinase
Gene Name ARAF
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9499
Serine/threonine-protein kinase receptor R3
Name Serine/threonine-protein kinase receptor R3
Gene Name ACVRL1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9523
Long-chain-fatty-acid--CoA ligase 1
Name Long-chain-fatty-acid--CoA ligase 1
Gene Name ACSL1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.039
Cytosolic purine 5'-nucleotidase
Name Cytosolic purine 5'-nucleotidase
Gene Name NT5C2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score Not Available
Arsenical pump-driving ATPase
Name Arsenical pump-driving ATPase
Gene Name ASNA1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.95
ATP-binding cassette transporter sub-family C member 9
Name ATP-binding cassette transporter sub-family C member 9
Gene Name ABCC9
Pharmacological action unknown
Actions Not Available
References
  • Zhao JL, Yang YJ, You SJ, Jing ZC, Wu YJ, Cheng JL, Gao RL: Pretreatment with fosinopril or valsartan reduces myocardial no-reflow after acute myocardial infarction and reperfusion. Coron Artery Dis. 2006 Aug;17(5):463-9. - Pubmed
  • Yang YJ, Zhao JL, You SJ, Wu YJ, Jing ZC, Gao RL, Chen ZJ: Post-infarction treatment with simvastatin reduces myocardial no-reflow by opening of the KATP channel. Eur J Heart Fail. 2007 Jan;9(1):30-6. Epub 2006 Jul 7. - Pubmed
  • Bryan J, Munoz A, Zhang X, Dufer M, Drews G, Krippeit-Drews P, Aguilar-Bryan L: ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch. 2007 Feb;453(5):703-18. Epub 2006 Aug 8. - Pubmed
DTHybrid score 0.7518
RAC-alpha serine/threonine-protein kinase
Name RAC-alpha serine/threonine-protein kinase
Gene Name AKT1
Pharmacological action unknown
Actions Not Available
References
  • Van Meter TE, Broaddus WC, Cash D, Fillmore H: Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas. Cancer. 2006 Nov 15;107(10):2446-54. - Pubmed
DTHybrid score 0.9239
Beta-adrenergic receptor kinase 1
Name Beta-adrenergic receptor kinase 1
Gene Name ADRBK1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9552
Apoptotic protease-activating factor 1
Name Apoptotic protease-activating factor 1
Gene Name APAF1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Chinnaiyan AM: The apoptosome: heart and soul of the cell death machine. Neoplasia. 1999 Apr;1(1):5-15. - Pubmed
DTHybrid score 0.8618
Acetyl-coenzyme A synthetase 2-like, mitochondrial
Name Acetyl-coenzyme A synthetase 2-like, mitochondrial
Gene Name ACSS1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0395
Activin receptor type 1B
Name Activin receptor type 1B
Gene Name ACVR1B
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9512
Activin receptor type-1
Name Activin receptor type-1
Gene Name ACVR1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1264
Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Pharmacological action unknown
Actions Not Available
References
  • Snow KL, Moseley RH: Effect of thiazolidinediones on bile acid transport in rat liver. Life Sci. 2007 Jan 30;80(8):732-40. Epub 2006 Nov 10. - Pubmed
  • Suchy FJ, Ananthanarayanan M: Bile salt excretory pump: biology and pathobiology. J Pediatr Gastroenterol Nutr. 2006 Jul;43 Suppl 1:S10-6. - Pubmed
DTHybrid score 0.4937
Asparagine synthetase [glutamine-hydrolyzing]
Name Asparagine synthetase [glutamine-hydrolyzing]
Gene Name ASNS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5767
Serine/threonine-protein kinase ALS2CR7
Name Serine/threonine-protein kinase ALS2CR7
Gene Name CDK15
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9501
ADP/ATP translocase 1
Name ADP/ATP translocase 1
Gene Name SLC25A4
Pharmacological action unknown
Actions Not Available
References
  • Walther T, Tschope C, Sterner-Kock A, Westermann D, Heringer-Walther S, Riad A, Nikolic A, Wang Y, Ebermann L, Siems WE, Bader M, Shakibaei M, Schultheiss HP, Dorner A: Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease. Circulation. 2007 Jan 23;115(3):333-44. Epub 2007 Jan 8. - Pubmed
DTHybrid score 1.5249
ATP-binding cassette transporter sub-family C member 8
Name ATP-binding cassette transporter sub-family C member 8
Gene Name ABCC8
Pharmacological action unknown
Actions Not Available
References
  • Nakamura A, Kawahito S, Kawano T, Nazari H, Takahashi A, Kitahata H, Nakaya Y, Oshita S: Differential effects of etomidate and midazolam on vascular adenosine triphosphate-sensitive potassium channels: isometric tension and patch clamp studies. Anesthesiology. 2007 Mar;106(3):515-22. - Pubmed
  • Bienengraeber M, Warltier DC, Bosnjak ZJ, Stadnicka A: Mechanism of cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel activation by isoflurane in a heterologous expression system. Anesthesiology. 2006 Sep;105(3):534-40. - Pubmed
  • Bryan J, Munoz A, Zhang X, Dufer M, Drews G, Krippeit-Drews P, Aguilar-Bryan L: ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch. 2007 Feb;453(5):703-18. Epub 2006 Aug 8. - Pubmed
  • Tanaka K, Kawano T, Nakamura A, Nazari H, Kawahito S, Oshita S, Takahashi A, Nakaya Y: Isoflurane activates sarcolemmal adenosine triphosphate-sensitive potassium channels in vascular smooth muscle cells: a role for protein kinase A. Anesthesiology. 2007 May;106(5):984-91. - Pubmed
DTHybrid score 0.7373
Argininosuccinate synthase
Name Argininosuccinate synthase
Gene Name ASS1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6159
AFG3-like protein 2
Name AFG3-like protein 2
Gene Name AFG3L2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9496
Beta-adrenergic receptor kinase 2
Name Beta-adrenergic receptor kinase 2
Gene Name ADRBK2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9552
Anti-Muellerian hormone type-2 receptor
Name Anti-Muellerian hormone type-2 receptor
Gene Name AMHR2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9499
Activated CDC42 kinase 1
Name Activated CDC42 kinase 1
Gene Name TNK2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1183
Proto-oncogene tyrosine-protein kinase ABL1
Name Proto-oncogene tyrosine-protein kinase ABL1
Gene Name ABL1
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.1707
Adenylate cyclase type 1
Name Adenylate cyclase type 1
Gene Name ADCY1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0389

Enzymes


Adenosine kinase
Name Adenosine kinase
Gene Name ADK
Actions substrate
References
  • -
  • Park J, Gupta RS: Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci. 2008 Sep;65(18):2875-96. - Pubmed
  • Leoncini R, Vannoni D, Santoro A, Giglioni S, Carli R, Marinello E: Adenosine kinase from rat liver: new biochemical properties. Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1107-12. - Pubmed
DTHybrid score 1.4465

Predictions


Id Partner name Gene Name Score
3435 Arsenical pump-driving ATPase arsA 0.95
865 Argininosuccinate synthase ASS1 0.6159
2680 Argininosuccinate synthase argG 0.6159
3194 Argininosuccinate synthase argG 0.6159
3318 Dual specificity protein kinase CLK1 CLK1 0.3455
851 5'-AMP-activated protein kinase subunit beta-2 PRKAB2 0.2731
388 AMP deaminase 1 AMPD1 0.273
768 FK506-binding protein 1A FKBP1A 0.2217
1721 Glycogen synthase kinase-3 beta GSK3B 0.2215
1291 cAMP response element-binding protein CREB1 0.2017
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.1957
4512 Cytochrome P450 3A4 CYP3A4 0.1927
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.1871
1900 Bactericidal permeability-increasing protein BPI 0.1771
128 Adenine phosphoribosyltransferase APRT 0.1584
311 RNA-directed RNA polymerase catalytic subunit PB1 0.1447
752 Large structural protein L 0.1447
4757 Cytochrome P450 2C9 CYP2C9 0.1382
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.1316
4604 Liver carboxylesterase 1 CES1 0.1304
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.1274
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1258
6171 Solute carrier family 28 member 3 SLC28A3 0.1232
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.1223
10 Glycogen phosphorylase, liver form PYGL 0.1179
508 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 0.1083
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.1081
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.1039
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.1018
4119 Cytochrome P450 2D6 CYP2D6 0.0983
6016 Cytochrome P450 2C19 CYP2C19 0.0964
4118 Cytochrome P450 3A5 CYP3A5 0.096
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.095
6544 STE20-like serine/threonine-protein kinase SLK 0.0931
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0929
6546 Dual specificity protein kinase CLK3 CLK3 0.0929
6545 Calcium/calmodulin-dependent protein kinase type IV CAMK4 0.0926
862 Multidrug resistance-associated protein 1 ABCC1 0.0908
4924 Cytochrome P450 2C8 CYP2C8 0.0867
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.083
6460 Casein kinase I isoform gamma-3 CSNK1G3 0.0816
782 ADP/ATP translocase 2 SLC25A5 0.081
688 ADP/ATP translocase 3 SLC25A6 0.0808
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0799
587 Serum albumin ALB 0.0775
3977 ASRGL1 protein ASRGL1 0.0737
6144 Solute carrier family 22 member 2 SLC22A2 0.0728
6145 Solute carrier family 22 member 1 SLC22A1 0.0711
1729 Solute carrier family 22 member 6 SLC22A6 0.0708
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.07
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0692
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0683
6151 Monocarboxylate transporter 10 SLC16A10 0.0648
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0643
4200 Cytochrome P450 1A2 CYP1A2 0.0629
504 Mast/stem cell growth factor receptor KIT 0.0621
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0606
6107 Cytochrome P450 3A7 CYP3A7 0.0597
6024 Cytochrome P450 1A1 CYP1A1 0.0582
263 Neutral amino acid transporter B(0) SLC1A5 0.0577
2379 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide DAPP1 0.0569
2348 Pleckstrin homology domain-containing family A member 4 PLEKHA4 0.0569
2355 Tyrosine-protein kinase BTK BTK 0.0568
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0552
1898 Cytochrome P450 1B1 CYP1B1 0.0543
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0523
669 Asparaginyl-tRNA synthetase, cytoplasmic NARS 0.0522
4092 Probable asparaginyl-tRNA synthetase, mitochondrial NARS2 0.0521
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0521
314 System N amino acid transporter 1 SLC38A3 0.0517
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0507
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.05
6141 Sodium/bile acid cotransporter SLC10A1 0.0473
6030 Cytochrome P450 2B6 CYP2B6 0.0467
6143 Solute carrier family 22 member 7 SLC22A7 0.0441
4534 Cytohesin-2 CYTH2 0.041
228 Beta platelet-derived growth factor receptor PDGFRB 0.04
936 Ephrin type-A receptor 2 EPHA2 0.0389
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0382
1063 Signal transducer and activator of transcription 5B STAT5B 0.038
2164 Multidrug resistance-associated protein 4 ABCC4 0.038
390 Adenosine A3 receptor ADORA3 0.038
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0367
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0363
290 Prostaglandin G/H synthase 2 PTGS2 0.0363
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0362
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0357
268 Adenosine A2b receptor ADORA2B 0.0356
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0351
118 Organic cation/carnitine transporter 2 SLC22A5 0.0341
843 NG,NG-dimethylarginine dimethylaminohydrolase 1 DDAH1 0.034
670 NG,NG-dimethylarginine dimethylaminohydrolase 2 DDAH2 0.034
4066 Protein-arginine deiminase type-1 PADI1 0.034
4067 Protein-arginine deiminase type-3 PADI3 0.034
4068 Protein-arginine deiminase type-2 PADI2 0.034
4065 Protein-arginine deiminase type-6 PADI6 0.034
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.034
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0339
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0333
2632 Adenylosuccinate synthetase purA 0.0332
3323 Adenylosuccinate synthetase purA 0.0332
3975 Adenylosuccinate synthetase ADSS 0.0332
4598 Adenylosuccinate synthetase Adss 0.0332
6817 Adenylosuccinate synthetase purA 0.0332
209 Aspartoacylase ASPA 0.0331
3979 Aspartoacylase-2 ACY3 0.0331
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.0331
533 Aminoacylase-1 ACY1 0.0331
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.0331
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.0331
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.0331
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.0331
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.0331
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.0331
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0327
7 Nitric oxide synthase, inducible NOS2 0.0324
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0306
1569 G1/S-specific cyclin-D1 CCND1 0.0298
291 Nitric-oxide synthase, endothelial NOS3 0.0297
6013 Cytochrome P450 2E1 CYP2E1 0.0295
1671 Excitatory amino acid transporter 3 SLC1A1 0.0294
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.029
150 Cationic amino acid transporter 3 SLC7A3 0.0289
58 Cationic amino acid transporter 4 SLC7A4 0.0289
1629 Transcription factor AP-1 JUN 0.0289
6824 Tyrosine-protein kinase Lyn LYN 0.0285
6148 Multidrug resistance-associated protein 7 ABCC10 0.0283
499 Arginine decarboxylase ADC 0.0283
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0282
834 Arginase-2, mitochondrial ARG2 0.0282
3877 Growth-inhibiting protein 18 GIG18 0.0282
1178 Adenosine A2a receptor ADORA2A 0.028
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0271
1814 Protein-arginine deiminase type-4 PADI4 0.0269
16 Adenosine A1 receptor ADORA1 0.0266
577 Argininosuccinate lyase ASL 0.0262
6142 Solute carrier family 22 member 8 SLC22A8 0.0261
833 Organic cation/carnitine transporter 1 SLC22A4 0.0261
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0261
426 Aspartate aminotransferase, mitochondrial GOT2 0.0259
3957 Adenosine deaminase ADA 0.0257
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0257
1714 Mitogen-activated protein kinase 3 MAPK3 0.0253
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0252
20 Prostaglandin G/H synthase 1 PTGS1 0.0243
336 Ornithine carbamoyltransferase, mitochondrial OTC 0.024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0237
183 Vascular endothelial growth factor A VEGFA 0.0235
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0223
136 Estrogen receptor ESR1 0.0217
1176 Mitogen-activated protein kinase 1 MAPK1 0.0212
2417 Chloramphenicol acetyltransferase cat 0.0207
3278 Chloramphenicol acetyltransferase cat 0.0207
817 DNA topoisomerase 2-alpha TOP2A 0.0207
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0205
6137 Multidrug resistance-associated protein 6 ABCC6 0.0199
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0199
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0199
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0196
5718 Cytochrome P450 2A6 CYP2A6 0.0193
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0192
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0192
2599 Tyrosine-protein kinase HCK HCK 0.0191
70 Type-1 angiotensin II receptor AGTR1 0.0186
5682 Ribonuclease pancreatic RNASE1 0.0186
683 Potassium transporter GK0582 0.0185
3270 Elongation factor G fusA 0.0181
738 Monocarboxylate transporter 1 SLC16A1 0.0177
76 Nitric-oxide synthase, brain NOS1 0.0177
2808 Chloramphenicol acetyltransferase 3 cat3 0.0174
1024 Solute carrier family 22 member 11 SLC22A11 0.0171
917 Glutaminase kidney isoform, mitochondrial GLS 0.0168
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0168
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0168
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0168
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0168
5 Glutaminase liver isoform, mitochondrial GLS2 0.0168
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0168
5261 Phosphoribosylformylglycinamidine synthase purL 0.0168
6106 Cytochrome P450 2C18 CYP2C18 0.0162
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.016
5787 Angiopoietin-1 receptor TEK 0.016
407 Vascular endothelial growth factor receptor 2 KDR 0.0159
13 Aminomethyltransferase, mitochondrial AMT 0.0154
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0151
477 DNA topoisomerase 4 subunit A parC 0.0149
886 DNA topoisomerase 4 subunit A parC 0.0149
6226 DNA topoisomerase 4 subunit A parC 0.0149
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0146
404 DNA gyrase subunit A gyrA 0.0146
6224 DNA gyrase subunit A gyrA 0.0146
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0145
823 Fibroblast growth factor receptor 2 FGFR2 0.0144
3811 Cytochrome P450 19A1 CYP19A1 0.0141
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0141
1008 CTP synthase 1 CTPS 0.0141
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0141
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0141
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0141
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0141
3989 Glutaminyl-tRNA synthetase QARS 0.0141
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0141
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0141
161 Tubulin beta chain TUBB 0.0138
312 Tubulin beta chain TUB2 0.0138
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0138
6147 Solute carrier family 22 member 3 SLC22A3 0.0135
165 FL cytokine receptor FLT3 0.0127
556 Alpha-1A adrenergic receptor ADRA1A 0.0124
2216 Fibroblast growth factor receptor 4 FGFR4 0.0123
614 Progesterone receptor PGR 0.0121
3923 Cholinesterase BCHE 0.012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0117
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0117
871 Glucocorticoid receptor NR3C1 0.0117
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0116
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0115
49 Endothelin B receptor EDNRB 0.0113
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0113
1618 High affinity nerve growth factor receptor NTRK1 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
26 Vascular endothelial growth factor receptor 3 FLT4 0.0109
413 Amidophosphoribosyltransferase PPAT 0.0109
2515 Amidophosphoribosyltransferase purF 0.0109
3714 Amidophosphoribosyltransferase purF 0.0109
2443 Azurin azu 0.0108
33 Cystine/glutamate transporter SLC7A11 0.0107
578 Endothelin-1 receptor EDNRA 0.0106
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0106
32 Vascular endothelial growth factor receptor 1 FLT1 0.0105
887 DNA gyrase subunit B gyrB 0.0105
4150 DNA gyrase subunit B gyrB 0.0105
6225 DNA gyrase subunit B gyrB 0.0105
831 D(2) dopamine receptor DRD2 0.0104
824 Sodium-dependent serotonin transporter SLC6A4 0.0103
6 Coagulation factor XIII A chain F13A1 0.0103
4120 NADPH--cytochrome P450 reductase POR 0.0102
131 Synaptic vesicular amine transporter SLC18A2 0.0099
492 Histamine H1 receptor HRH1 0.0097
468 Cytochrome P450 4A11 CYP4A11 0.0096
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0096
185 Vasopressin V1a receptor AVPR1A 0.0096
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0096
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0095
6136 Multidrug resistance-associated protein 5 ABCC5 0.0094
322 Vasopressin V2 receptor AVPR2 0.0093
193 Beta-1 adrenergic receptor ADRB1 0.0093
5304 UPF0166 protein TM_0021 TM_0021 0.0092
5287 Signaling protein Not Available 0.0092
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0092
5293 Shikimate kinase 2 aroL 0.0092
5288 Shikimate kinase aroK 0.0092
5283 D-alanine--D-alanine ligase B ddlB 0.0092
3199 Phosphopantetheine adenylyltransferase coaD 0.0092
3543 Phosphopantetheine adenylyltransferase coaD 0.0092
3567 Phosphopantetheine adenylyltransferase coaD 0.0092
5289 Phosphopantetheine adenylyltransferase coaD 0.0092
5281 Plasmid segregation protein parM parM 0.0092
5292 Putative partitioning protein TT_C1605 0.0092
5276 Chromosomal replication initiator protein dnaA dnaA 0.0092
5266 Activator of hgdC 0.0092
5264 DNA replication protein REP 0.0092
5259 Transcriptional regulator ntrC1 0.0092
6699 Transcriptional regulator Cgl2612 0.0092
2874 Nitrogenase iron protein 1 nifH1 0.0092
4346 Polynucleotide kinase pseT 0.0092
5291 Glycogen synthase 1 glgA1 0.0092
5299 D-alanine--D-alanine ligase ddl 0.0092
6598 D-alanine--D-alanine ligase ddl 0.0092
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0092
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0092
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0092
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0092
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0092
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0092
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0092
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0092
5308 Preprotein translocase secA 1 subunit secA1 0.0092
5285 Kinesin heavy chain KIF5B 0.0092
5315 Chaperone protein htpG htpG 0.0092
5284 Large T antigen Not Available 0.0092
5277 Preprotein translocase subunit secA secA 0.0092
5294 Nucleoside diphosphate kinase A NME1 0.0091
3947 Xanthine dehydrogenase/oxidase XDH 0.0091
731 HIV-1 protease HIV-1 protease 0.009
540 Sodium-dependent noradrenaline transporter SLC6A2 0.009
5300 Antigen peptide transporter 1 TAP1 0.0089
2240 Cell division protein kinase 2 CDK2 0.0088
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0088
702 UMP-CMP kinase CMPK1 0.0087
1192 Sulfotransferase 1A1 SULT1A1 0.0085
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0085
2449 Tubulin alpha-3 chain TUBA1A 0.0085
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0085
6167 Organic solute transporter subunit beta OSTB 0.0084
6166 Organic solute transporter subunit alpha OSTA 0.0084
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0084
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0083
502 5-hydroxytryptamine 2A receptor HTR2A 0.0082
1852 Microtubule-associated protein 2 MAP2 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
5798 Mitogen-activated protein kinase 11 MAPK11 0.0081
4837 Cag-alfa cag-alfa 0.008
4839 DNA polymerase III subunit tau dnaX 0.008
4838 PMS1 protein homolog 2 PMS2 0.008
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0079
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0078
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0078
5302 TrwB trwB 0.0078
5646 Galactokinase GALK1 0.0078
5265 FtsH ftsH 0.0078
6211 Tubulin epsilon chain TUBE1 0.0078
2616 Ganglioside GM2 activator GM2A 0.0078
6210 Tubulin delta chain TUBD1 0.0078
6212 Tubulin gamma-1 chain TUBG1 0.0078
4106 Guanylate kinase GUK1 0.0078
4516 Guanylate kinase gmk 0.0078
2270 Dephospho-CoA kinase coaE 0.0077
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0077
4774 NTPase P4 Not Available 0.0077
632 Alpha-1B adrenergic receptor ADRA1B 0.0076
2284 Adenylate kinase adk 0.0076
2296 Adenylate kinase adk 0.0076
2311 Adenylate kinase adk 0.0076
2312 Adenylate kinase Not Available 0.0076
6277 Heat shock cognate 71 kDa protein HSPA8 0.0076
5189 Trimethylamine dehydrogenase tmd 0.0076
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0075
737 Mineralocorticoid receptor NR3C2 0.0075
24 Thymidylate synthase TMP1 0.0075
359 Thymidylate synthase TYMS 0.0075
2626 Thymidylate synthase thyA 0.0075
2729 Thymidylate synthase thyA 0.0075
5352 Thymidylate synthase THYA 0.0075
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0075
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0075
4773 Deoxycytidine kinase DCK 0.0074
380 Cytochrome P450 17A1 CYP17A1 0.0074
29 Tubulin beta-1 chain TUBB1 0.0074
2282 Protein recA recA 0.0073
2315 Protein recA recA 0.0073
2332 Protein recA recA 0.0073
5263 Protein recA recA 0.0073
260 Cytochrome P450 51 ERG11 0.0073
761 Cytochrome P450 51 ERG11 0.0073
3163 Cytochrome P450 51 cyp51 0.0073
3470 Hypothetical protein MG245 homolog MPN_348 0.0073
2539 Tubulin alpha-1 chain TUBA4A 0.0073
465 Calmodulin CALM1 0.0072
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0072
3426 Glutamine synthetase glnA 0.0072
3987 Glutamine synthetase GLUL 0.0072
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0072
3175 Glutamate--cysteine ligase gshA 0.0072
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0072
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0072
5923 Microtubule-associated protein tau MAPT 0.0071
5924 Microtubule-associated protein 4 MAP4 0.0071
5312 Kinesin-like protein KIF1A KIF1A 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
2390 Nonsecretory ribonuclease RNASE2 0.0071
766 Beta-2 adrenergic receptor ADRB2 0.007
2922 Glycerol kinase glpK 0.0069
2683 Mono-ADP-ribosyltransferase C3 C3 0.0069
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0069
320 5-hydroxytryptamine 1A receptor HTR1A 0.0068
408 Riboflavin kinase RFK 0.0068
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0068
908 Glutathione S-transferase theta-1 GSTT1 0.0067
2615 Chemotaxis protein cheA cheA 0.0067
273 Apoptosis regulator Bcl-2 BCL2 0.0066
23 D(1A) dopamine receptor DRD1 0.0066
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0066
1864 RET proto-oncogene RET 0.0065
5271 Focal adhesion kinase 1 PTK2 0.0065
4192 DNA topoisomerase 2-beta TOP2B 0.0065
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0065
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0064
3587 Gastrotropin FABP6 0.0064
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0064
1353 DNA topoisomerase 1 TOP1 0.0064
3552 DNA topoisomerase 1 topA 0.0064
2371 Pantothenate kinase coaA 0.0064
1881 Hexokinase-1 HK1 0.0064
6085 Fatty acid-binding protein, intestinal FABP2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
275 Arachidonate 5-lipoxygenase ALOX5 0.0063
869 Estrogen receptor beta ESR2 0.0063
3669 Ribokinase rbsK 0.0063
2892 Acetylglutamate kinase argB 0.0062
3550 Acetylglutamate kinase argB 0.0062
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0062
904 Glutathione S-transferase P GSTP1 0.0062
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0061
2727 S-adenosylmethionine synthetase metK 0.0061
207 Glutathione synthetase GSS 0.0061
5269 Glutathione synthetase gshB 0.0061
6031 Cytochrome P450 3A43 CYP3A43 0.006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.006
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0059
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0059
124 Histamine H2 receptor HRH2 0.0059
788 Creatine kinase M-type CKM 0.0059
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0059
2697 Uridine-cytidine kinase 2 UCK2 0.0058
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0058
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0058
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0058
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0058
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0057
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0057
48 Pyridoxal kinase PDXK 0.0057
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0056
777 Tumor necrosis factor TNF 0.0056
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0055
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0055
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0055
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0055
2251 Thymidylate kinase tmk 0.0054
2254 Thymidylate kinase DTYMK 0.0054
3522 Thymidylate kinase tmk 0.0054
2334 Dethiobiotin synthetase bioD 0.0054
6555 Dethiobiotin synthetase bioD 0.0054
5626 Nucleoside diphosphate kinase B NME2 0.0054
6182 Cytochrome P450 2J2 CYP2J2 0.0052
2091 Endoplasmin HSP90B1 0.0052
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0052
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0052
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0052
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0052
1912 Excitatory amino acid transporter 1 SLC1A3 0.0052
4020 Glutamyl aminopeptidase ENPEP 0.0052
4026 Aspartyl aminopeptidase DNPEP 0.0052
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0052
4016 Excitatory amino acid transporter 5 SLC1A7 0.0052
4019 Excitatory amino acid transporter 4 SLC1A6 0.0052
1047 Excitatory amino acid transporter 2 SLC1A2 0.0052
664 Glutamate decarboxylase 2 GAD2 0.0052
3890 Glutamate decarboxylase 2 GAD2 0.0052
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0052
927 Metabotropic glutamate receptor 8 GRM8 0.0052
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0052
922 Glutamate receptor 4 GRIA4 0.0052
925 Metabotropic glutamate receptor 4 GRM4 0.0052
926 Metabotropic glutamate receptor 7 GRM7 0.0052
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0052
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0052
4018 Glutamate receptor delta-2 subunit GRID2 0.0052
4027 Glutamate receptor delta-1 subunit GRID1 0.0052
4017 5-oxoprolinase OPLAH 0.0052
6755 Poliovirus receptor PVR 0.0051
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0051
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0051
6395 Myosin-14 MYH14 0.005
789 Alpha-1D adrenergic receptor ADRA1D 0.005
844 Epidermal growth factor receptor EGFR 0.005
6163 Copper-transporting ATPase 2 ATP7B 0.005
6165 Copper-transporting ATPase 1 ATP7A 0.005
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.005
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0049
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0049
3809 Estrogen-related receptor gamma ESRRG 0.0049
146 Androgen receptor AR 0.0048
847 Mu-type opioid receptor OPRM1 0.0048
1422 Serine/threonine-protein kinase 6 AURKA 0.0048
6146 High affinity copper uptake protein 1 SLC31A1 0.0047
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0047
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0047
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0047
461 Glycine receptor subunit alpha-3 GLRA3 0.0047
509 Thymidine kinase TK 0.0047
570 Thymidine kinase TK 0.0047
2559 Thymidine kinase TK 0.0047
3430 Thymidine kinase tdk 0.0047
3518 Thymidine kinase TK 0.0047
5301 Thymidine kinase tdk 0.0047
5771 Thymidine kinase ORF36 0.0047
7009 Thymidine kinase ORF36 0.0047
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0046
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0046
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0046
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0046
3379 Kinesin-like protein KIF11 KIF11 0.0046
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0046
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0045
318 Alpha-2A adrenergic receptor ADRA2A 0.0045
3822 Actin, alpha skeletal muscle ACTA1 0.0045
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0045
896 Glutathione S-transferase Mu 1 GSTM1 0.0045
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0044
952 Dipeptidyl peptidase 4 DPP4 0.0044
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0043
467 Delta-type opioid receptor OPRD1 0.0043
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0043
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0043
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0042
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0042
6599 HTH-type transcriptional regulator ttgR ttgR 0.0041
469 Annexin A1 ANXA1 0.0041
394 Calcineurin subunit B isoform 1 PPP3R1 0.0041
6753 Apolipoprotein M APOM 0.0041
6742 Recoverin RCVRN 0.0041
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0041
6747 Chalcone/stilbene synthase family protein MT1417 0.0041
6743 Non-fluorescent flavoprotein luxF 0.0041
2528 Fatty acid metabolism regulator protein fadR 0.0041
6740 Fatty acid metabolism regulator protein fadR 0.0041
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0041
6751 Gag polyprotein gag 0.0041
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0041
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0041
6749 Polyprotein Not Available 0.0041
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0041
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.004
436 5-hydroxytryptamine 2B receptor HTR2B 0.004
2297 Genome polyprotein Not Available 0.004
2322 Genome polyprotein Not Available 0.004
2694 Genome polyprotein Not Available 0.004
2719 Genome polyprotein Not Available 0.004
2860 Genome polyprotein Not Available 0.004
2928 Genome polyprotein Not Available 0.004
3160 Genome polyprotein Not Available 0.004
3260 Genome polyprotein Not Available 0.004
4783 Genome polyprotein Not Available 0.004
5726 Genome polyprotein Not Available 0.004
5779 Genome polyprotein Not Available 0.004
5867 Genome polyprotein Not Available 0.004
6253 Genome polyprotein Not Available 0.004
6301 Genome polyprotein Not Available 0.004
6380 Genome polyprotein Not Available 0.004
6381 Genome polyprotein Not Available 0.004
6437 Genome polyprotein Not Available 0.004
6520 Genome polyprotein Not Available 0.004
6521 Genome polyprotein Not Available 0.004
6652 Genome polyprotein Not Available 0.004
6734 Genome polyprotein Not Available 0.004
6735 Genome polyprotein Not Available 0.004
6736 Genome polyprotein Not Available 0.004
6737 Genome polyprotein Not Available 0.004
6738 Genome polyprotein Not Available 0.004
6739 Genome polyprotein Not Available 0.004
6744 Genome polyprotein Not Available 0.004
6748 Genome polyprotein Not Available 0.004
6894 Genome polyprotein Not Available 0.004
6898 Genome polyprotein Not Available 0.004
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.004
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.004
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.004
420 Glutamate decarboxylase 1 GAD1 0.004
3900 Glutamate decarboxylase 1 GAD1 0.004
665 Phosphoserine aminotransferase PSAT1 0.004
4652 Phosphoserine aminotransferase serC 0.004
696 Kappa-type opioid receptor OPRK1 0.004
474 Acetylcholinesterase ACHE 0.004
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0039
751 Potassium channel subfamily K member 6 KCNK6 0.0039
625 Glutamate carboxypeptidase 2 FOLH1 0.0039
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0039
4210 Toll-like receptor 4 TLR4 0.0038
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0038
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0038
921 Glutamate receptor 2 GRIA2 0.0038
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0038
885 5-hydroxytryptamine 1B receptor HTR1B 0.0038
725 5-hydroxytryptamine 1D receptor HTR1D 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
916 Metabotropic glutamate receptor 1 GRM1 0.0037
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0037
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0037
1757 Myeloperoxidase MPO 0.0036
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0036
172 Potassium channel subfamily K member 1 KCNK1 0.0036
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0036
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
5961 Insulin INS 0.0036
6149 Solute carrier family 22 member 10 SLC22A10 0.0036
1010 Cytochrome P450 51A1 CYP51A1 0.0036
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0036
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0036
84 Nuclear receptor 0B1 NR0B1 0.0036
6527 Lymphocyte antigen 96 LY96 0.0036
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0036
1650 Heme carrier protein 1 SLC46A1 0.0036
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
923 Glutamate receptor 3 GRIA3 0.0035
2391 Ferrochelatase hemH 0.0035
6502 Ferrochelatase DKFZp686P18130 0.0035
1591 Ferrochelatase, mitochondrial FECH 0.0035
763 Tyrosine aminotransferase TAT 0.0035
5493 Tyrosine aminotransferase Not Available 0.0035
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0035
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0035
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0035
735 Alanine aminotransferase 1 GPT 0.0035
3904 Alanine aminotransferase 2 GPT2 0.0035
6168 Solute carrier family 22 member 16 SLC22A16 0.0034
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0034
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0034
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0034
1760 Aminopeptidase N ANPEP 0.0034
6843 Aminopeptidase N pepN 0.0034
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0034
6750 ADP-ribosylation factor 6 ARF6 0.0033
3941 Amine oxidase [flavin-containing] A MAOA 0.0033
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0033
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0033
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0033
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0033
117 Sterol O-acyltransferase 1 SOAT1 0.0033
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0033
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0033
6524 Protein tonB tonB 0.0033
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0033
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0033
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0033
3939 Amine oxidase [flavin-containing] B MAOB 0.0032
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0032
6316 ADP-ribosylation factor 1 ARF1 0.0032
284 DNA-directed RNA polymerase beta chain rpoB 0.0032
5773 DNA-directed RNA polymerase beta chain rpoB 0.0032
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0031
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0031
638 D(3) dopamine receptor DRD3 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0031
705 Glutamate receptor 1 GRIA1 0.003
756 Sex hormone-binding globulin SHBG 0.003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.003
590 5-hydroxytryptamine 2C receptor HTR2C 0.003
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.003
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.003
6493 Cytochrome c oxidase subunit 6C COX6C 0.003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.003
6559 Cytochrome c oxidase subunit 2 ctaC 0.003
6669 Cytochrome c oxidase subunit 2 ctaC 0.003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.003
6558 Cytochrome c oxidase subunit 1 ctaD 0.003
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.003
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0029
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0029
629 Alpha-2B adrenergic receptor ADRA2B 0.0029
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0029
6228 Nuclear receptor coactivator 1 NCOA1 0.0028
5934 Cytochrome P450 26A1 CYP26A1 0.0028
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
2540 Choloylglycine hydrolase cbh 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0027
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0027
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0027
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0027
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0027
267 Plasminogen activator inhibitor 1 SERPINE1 0.0027
489 Monocarboxylate transporter 2 SLC16A7 0.0026
864 Gag-Pol polyprotein gag-pol 0.0026
2237 Gag-Pol polyprotein gag-pol 0.0026
2326 Gag-Pol polyprotein gag-pol 0.0026
2451 Gag-Pol polyprotein gag-pol 0.0026
2901 Gag-Pol polyprotein gag-pol 0.0026
3165 Gag-Pol polyprotein gag-pol 0.0026
3722 Gag-Pol polyprotein gag-pol 0.0026
6306 Gag-Pol polyprotein gag-pol 0.0026
6624 Gag-Pol polyprotein gag-pol 0.0026
818 50S ribosomal protein L10 rplJ 0.0026
1630 Integrin beta-2 ITGB2 0.0026
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0026
6837 Serine/threonine-protein kinase 17B STK17B 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6501 Fatty acid-binding protein, liver FABP1 0.0026
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
342 P protein [Includes: DNA-directed DNA polymerase P 0.0024
612 P protein [Includes: DNA-directed DNA polymerase P 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
6221 Steroid hormone receptor ERR1 ESRRA 0.0024
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0023
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
2427 Ferrichrome-iron receptor fhuA 0.0023
713 Sodium-dependent dopamine transporter SLC6A3 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0023
373 Transthyretin TTR 0.0023
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0023
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0023
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0022
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0022
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0022
716 5-hydroxytryptamine 7 receptor HTR7 0.0021
6500 Phospholipase A2 PLA2G1B 0.0021
6044 Serum paraoxonase/lactonase 3 PON3 0.0021
3917 Methylenetetrahydrofolate reductase MTHFR 0.0021
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0021
378 Alpha-2C adrenergic receptor ADRA2C 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
1656 CYP2B protein CYP2B 0.002
572 Integrin alpha-L ITGAL 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0019
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0019
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0019
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0019
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0019
517 Alcohol dehydrogenase 1C ADH1C 0.0019
365 Dihydrofolate reductase DHFR 0.0019
2381 Dihydrofolate reductase DFR1 0.0019
2833 Dihydrofolate reductase Not Available 0.0019
2931 Dihydrofolate reductase folA 0.0019
3544 Dihydrofolate reductase folA 0.0019
3682 Dihydrofolate reductase folA 0.0019
6642 Dihydrofolate reductase folA 0.0019
6756 Dihydrofolate reductase dfrA 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0019
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0019
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0019
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0018
4122 Histone deacetylase 2 HDAC2 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
594 Thyroxine-binding globulin SERPINA7 0.0017
6218 Pannexin-1 PANX1 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
1313 Lactoylglutathione lyase GLO1 0.0017
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
3810 Catechol O-methyltransferase COMT 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0015
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
5818 Folate receptor alpha FOLR1 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
6220 Aryl hydrocarbon receptor AHR 0.0015
6042 Prostaglandin reductase 2 PTGR2 0.0015
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
357 Carbonic anhydrase 2 CA2 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
6043 Putative G-protein coupled receptor 44 GPR44 0.0014
3932 Glutathione S-transferase A2 GSTA2 0.0014
2981 Phospholipase A2, membrane associated PLA2G2A 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
293 Gamma-glutamyl hydrolase GGH 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
6432 Transporter snf 0.0013
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0012
694 Matrix protein 2 M 0.0012
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0012
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0012
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0012
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0012
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0012
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6859 Protein S100-A4 S100A4 0.0012
432 D(4) dopamine receptor DRD4 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
427 Substance-P receptor TACR1 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
4203 Histamine N-methyltransferase HNMT 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
811 Translocator protein TSPO 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
723 Cytosolic phospholipase A2 PLA2G4A 0.001
68 Cannabinoid receptor 1 CNR1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
6020 Aldehyde oxidase AOX1 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
54 Prothrombin F2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
229 Retinoic acid receptor beta RARB 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
163 D(1B) dopamine receptor DRD5 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
1256 5-hydroxytryptamine 6 receptor HTR6 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
976 Platelet glycoprotein IX GP9 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
4041 Microsomal glutathione S-transferase 2 MGST2 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0006
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0006
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
341 5-hydroxytryptamine 3 receptor HTR3A 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
2021 Thrombomodulin THBD 0.0005
2207 Rhodopsin RHO 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
4031 Glutathione S-transferase A1 GSTA1 0.0005
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
6102 Arylamine N-acetyltransferase 2 NAT2 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
6014 Cytochrome P450 2A13 CYP2A13 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0003
295 Carbonic anhydrase 1 CA1 0.0003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0003
164 Histamine H4 receptor HRH4 0.0003
↑