DT-Web

DB01055 - Mimosine


Identification
Name Mimosine
Accession Number DB01055 (APRD00647)
Type small molecule
Description 3-Hydroxy-4-oxo-1(4H)-pyridinealanine. An antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 198.176
Groups approved
Monoisotopic Weight 198.064056818
Pharmacology
Indication Not Available
Mechanism of action Mimosine causes inhibition of DNA replication, changes in the progression of the cells in the cell cycle, and apoptosis. Mimosine appears to introduce breaks into DNA. Mimosine is an iron/zinc chelator. Iron depletion induces DNA double-strand breaks in treated cells, and activates a DNA damage response that results in focal phosphorylation of histones. This leads to inhibition of DNA replication and/or DNA elongation. Some studies indicate that mimosine prevents the initiation of DNA replication, whereas other studies indicate that mimosine disrupts elongation of the replication fork by impairing deoxyribonucleotide synthesis by inhibiting the activity of the iron-dependent enzyme ribonucleotide reductase and the transcription of the cytoplasmic serine hydroxymethyltransferase gene (SHMT). Inhibition of serine hydroxymethyltransferase is moderated by a zinc responsive unit located in front of the SHMT gene.
Absorption Not Available
Protein binding >99.5%
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Serine hydroxymethyltransferase, cytosolic
Name Serine hydroxymethyltransferase, cytosolic
Gene Name SHMT1
Pharmacological action yes
Actions inhibitor
References
  • Oppenheim EW, Nasrallah IM, Mastri MG, Stover PJ: Mimosine is a cell-specific antagonist of folate metabolism. J Biol Chem. 2000 Jun 23;275(25):19268-74. - Pubmed
  • Conti P, Frydas S, Reale M, Barbacane RC, Di Gioacchino M, Felaco M, Trakatellis A: Inhibition of MCP-1 and MIP-2 transcription and translation by mimosine in muscle tissue infected with the parasite Trichinella spiralis. Mol Cell Biochem. 2002 Jan;229(1-2):129-37. - Pubmed
  • Perry C, Sastry R, Nasrallah IM, Stover PJ: Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc. Implications for inhibition of DNA replication. J Biol Chem. 2005 Jan 7;280(1):396-400. Epub 2004 Nov 4. - Pubmed
  • Lin HB, Falchetto R, Mosca PJ, Shabanowitz J, Hunt DF, Hamlin JL: Mimosine targets serine hydroxymethyltransferase. J Biol Chem. 1996 Feb 2;271(5):2548-56. - Pubmed
DTHybrid score 0.725
Small inducible cytokine A2
Name Small inducible cytokine A2
Gene Name CCL2
Pharmacological action yes
Actions inhibitor
References
  • Conti P, Frydas S, Reale M, Barbacane RC, Di Gioacchino M, Felaco M, Trakatellis A: Inhibition of MCP-1 and MIP-2 transcription and translation by mimosine in muscle tissue infected with the parasite Trichinella spiralis. Mol Cell Biochem. 2002 Jan;229(1-2):129-37. - Pubmed
  • Frydas S, Papaioannou N, Papazahariadou M, Hatzistilianou M, Karagouni E, Trakatelli M, Brellou G, Petrarca C, Castellani ML, Conti P, Riccioni G, Patruno A, Grilli A: Inhibition of MCP-1 and MIP-2 chemokines in murine trichinellosis: effect of the anti-inflammatory compound L-mimosine. Int J Immunopathol Pharmacol. 2005 Jan-Mar;18(1):85-94. - Pubmed
DTHybrid score 0.5629
Tyrosinase
Name Tyrosinase
Gene Name TYR
Pharmacological action unknown
Actions inhibitor
References
  • Ahmad VU, Ullah F, Hussain J, Farooq U, Zubair M, Khan MT, Choudhary MI: Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies. Chem Pharm Bull (Tokyo). 2004 Dec;52(12):1458-61. - Pubmed
  • Khan KM, Mughal UR, Khan MT, Zia-Ullah, Perveen S, Choudhary MI: Oxazolones: new tyrosinase inhibitors; synthesis and their structure-activity relationships. Bioorg Med Chem. 2006 Sep 1;14(17):6027-33. Epub 2006 Jun 5. - Pubmed
  • Sugumaran M: Tyrosinase catalyzes an unusual oxidative decarboxylation of 3,4-dihydroxymandelate. Biochemistry. 1986 Aug 12;25(16):4489-92. - Pubmed
  • Woolery GL, Powers L, Winkler M, Solomon EI, Lerch K, Spiro TG: Extended X-ray absorption fine structure study of the coupled binuclear copper active site of tyrosinase from Neurospora crassa. Biochim Biophys Acta. 1984 Jul 31;788(2):155-61. - Pubmed
DTHybrid score 0.8095

Predictions


Id Partner name Gene Name Score
3470 Hypothetical protein MG245 homolog MPN_348 0.1428
526 Thioredoxin reductase trxB 0.0798
3767 Thioredoxin reductase trxB 0.0798
553 DNA polymerase I polA 0.0664
6373 DNA polymerase I polA 0.0664
3193 Serine hydroxymethyltransferase glyA 0.0652
3342 Serine hydroxymethyltransferase glyA 0.0652
226 Gonadotropin-releasing hormone receptor GNRHR 0.0598
4823 L-allo-threonine aldolase TM_1744 0.0594
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0576
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0531
756 Sex hormone-binding globulin SHBG 0.0512
449 Ornithine decarboxylase ODC1 0.0481
614 Progesterone receptor PGR 0.0473
3811 Cytochrome P450 19A1 CYP19A1 0.0385
146 Androgen receptor AR 0.0384
136 Estrogen receptor ESR1 0.0353
4512 Cytochrome P450 3A4 CYP3A4 0.0222
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0209
3879 Serine hydroxymethyltransferase 2 Not Available 0.0209
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0209
3884 SHMT2 protein SHMT2 0.0206
3901 SHMT2 protein SHMT2 0.0206
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0141
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0141
3763 5,10-methylenetetrahydrofolate reductase metF 0.0141
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0141
5094 5,10-methylenetetrahydrofolate reductase metF 0.0141
59 AMT protein AMT 0.0141
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0141
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0134
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0134
13 Aminomethyltransferase, mitochondrial AMT 0.0131
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0121
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0094
809 Methionine synthase MTR 0.0094
2935 Methionine synthase metH 0.0094
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0093
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0093
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0093
3917 Methylenetetrahydrofolate reductase MTHFR 0.008
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0078
349 Serine--pyruvate aminotransferase AGXT 0.0077
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0071
4057 Glycine N-acyltransferase GLYAT 0.0071
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0071
1466 Glycyl-tRNA synthetase GARS 0.0071
4056 N-arachidonyl glycine receptor GPR18 0.0071
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0071
4061 Peroxisomal sarcosine oxidase PIPOX 0.0071
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0071
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0071
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0071
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0071
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0063
62 Glycine receptor subunit beta GLRB 0.0057
411 Glycine N-methyltransferase GNMT 0.0057
383 Glycine amidinotransferase, mitochondrial GATM 0.0055
207 Glutathione synthetase GSS 0.0055
5269 Glutathione synthetase gshB 0.0055
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0052
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.005
593 Proton-coupled amino acid transporter 1 SLC36A1 0.005
461 Glycine receptor subunit alpha-3 GLRA3 0.0048
820 Glycine receptor subunit alpha-2 GLRA2 0.0048
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0047
3880 Serine hydroxymethyltransferase 1 Not Available 0.0044
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0044
482 Glycine receptor subunit alpha-1 GLRA1 0.0042
3911 Uncharacterized protein C20orf38 SPTLC3 0.0036
306 Pyridoxal phosphate phosphatase PDXP 0.0036
3881 Selenocysteine lyase variant Not Available 0.0036
3887 Phosphorylase PYGB 0.0036
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0036
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0036
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0036
3883 Ornithine aminotransferase variant Not Available 0.0036
3906 Serine dehydratase-like SDSL 0.0036
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0036
3891 Putative L-Dopa decarboxylase DDC 0.0036
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0036
664 Glutamate decarboxylase 2 GAD2 0.0036
3890 Glutamate decarboxylase 2 GAD2 0.0036
3886 Migration-inducing protein 4 ALAS1 0.0036
3878 GAD1 protein GAD1 0.0036
3893 DDC protein DDC 0.0036
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0036
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0036
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0036
3894 KIAA0251 protein PDXDC1 0.0036
3875 Glycogen phosphorylase, brain form PYGB 0.0036
3882 Brain glycogen phosphorylase variant Not Available 0.0036
3905 Molybdenum cofactor sulfurase MOCOS 0.0036
6151 Monocarboxylate transporter 10 SLC16A10 0.0036
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.003
184 L-serine dehydratase SDS 0.003
431 Serine racemase SRR 0.003
491 Serine palmitoyltransferase 1 SPTLC1 0.003
89 Cysteine sulfinic acid decarboxylase CSAD 0.003
727 Serine palmitoyltransferase 2 SPTLC2 0.003
534 Threonine synthase-like 1 THNSL1 0.003
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.003
665 Phosphoserine aminotransferase PSAT1 0.003
4652 Phosphoserine aminotransferase serC 0.003
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.003
420 Glutamate decarboxylase 1 GAD1 0.003
3900 Glutamate decarboxylase 1 GAD1 0.003
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.003
3 Histidine decarboxylase HDC 0.003
499 Arginine decarboxylase ADC 0.003
435 Kynureninase KYNU 0.003
4654 Kynureninase kynU 0.003
3913 Glutamic acid decarboxylase GAD65 0.003
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0029
472 Ornithine aminotransferase, mitochondrial OAT 0.0028
816 Biliverdin reductase A BLVRA 0.0028
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0028
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0028
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0028
169 Cysteine desulfurase, mitochondrial NFS1 0.0028
868 Cystathionine gamma-lyase CTH 0.0028
3877 Growth-inhibiting protein 18 GIG18 0.0027
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0027
426 Aspartate aminotransferase, mitochondrial GOT2 0.0027
358 Cystathionine beta-synthase CBS 0.0027
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0027
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0027
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0027
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0027
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0027
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0027
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0027
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0027
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0027
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0027
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0027
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0027
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0027
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0027
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0027
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0027
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0027
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0027
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0027
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0027
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0027
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0027
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0027
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0027
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0027
729 GDP-L-fucose synthetase TSTA3 0.0027
3463 GDP-L-fucose synthetase fcl 0.0027
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0027
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0027
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0027
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0027
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0027
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0027
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0027
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0027
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0027
107 C-4 methylsterol oxidase SC4MOL 0.0027
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0027
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0027
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0027
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0027
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0027
206 3-keto-steroid reductase HSD17B7 0.0027
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0027
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0027
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0027
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0027
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0027
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0027
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0027
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0027
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0027
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0027
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0027
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0027
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0027
644 Heme oxygenase 2 HMOX2 0.0027
4982 Heme oxygenase 2 pbsA2 0.0027
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0027
3726 D-3-phosphoglycerate dehydrogenase serA 0.0027
4291 D-3-phosphoglycerate dehydrogenase serA 0.0027
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0027
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0027
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0027
34 7-dehydrocholesterol reductase DHCR7 0.0027
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0027
711 UDP-glucose 6-dehydrogenase UGDH 0.0027
3672 UDP-glucose 6-dehydrogenase hasB 0.0027
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0027
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0027
167 L-lactate dehydrogenase C chain LDHC 0.0027
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0027
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0027
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0027
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0027
643 Peroxisomal bifunctional enzyme EHHADH 0.0027
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0027
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0027
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0027
735 Alanine aminotransferase 1 GPT 0.0026
3904 Alanine aminotransferase 2 GPT2 0.0026
763 Tyrosine aminotransferase TAT 0.0026
5493 Tyrosine aminotransferase Not Available 0.0026
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0025
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0025
646 Malate dehydrogenase, cytoplasmic MDH1 0.0024
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0024
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0024
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0024
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0024
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0024
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0024
328 Sorbitol dehydrogenase SORD 0.0023
597 Dihydropteridine reductase QDPR 0.0023
396 Alcohol dehydrogenase 4 ADH4 0.0023
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0023
10 Glycogen phosphorylase, liver form PYGL 0.0023
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0023
666 NADP-dependent malic enzyme ME1 0.0023
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0022
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0022
626 Cysteine dioxygenase type 1 CDO1 0.0022
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0022
857 Malate dehydrogenase, mitochondrial MDH2 0.0022
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0022
6026 Alcohol dehydrogenase 6 ADH6 0.0022
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0022
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0022
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0022
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0022
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0022
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0022
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0021
12 Alcohol dehydrogenase class 3 ADH5 0.0021
627 11-cis retinol dehydrogenase RDH5 0.0021
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0021
77 L-lactate dehydrogenase B chain LDHB 0.0021
569 Retinal dehydrogenase 2 ALDH1A2 0.0021
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0021
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0021
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.002
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.002
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.002
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.002
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.002
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.002
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.002
473 L-lactate dehydrogenase A chain LDHA 0.002
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.002
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0019
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0019
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0019
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0019
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0018
251 Alcohol dehydrogenase 1A ADH1A 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0018
1152 Glycogen phosphorylase, muscle form PYGM 0.0018
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0017
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0017
654 Flavin reductase BLVRB 0.0017
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0016
810 Heme oxygenase 1 HMOX1 0.0016
3391 Heme oxygenase 1 pbsA1 0.0016
444 Alcohol dehydrogenase 1B ADH1B 0.0016
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0016
380 Cytochrome P450 17A1 CYP17A1 0.0016
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0015
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0015
468 Cytochrome P450 4A11 CYP4A11 0.0015
714 Glutathione reductase, mitochondrial GSR 0.0015
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0015
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0015
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0015
6020 Aldehyde oxidase AOX1 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0014
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0013
3947 Xanthine dehydrogenase/oxidase XDH 0.0013
365 Dihydrofolate reductase DHFR 0.0012
2381 Dihydrofolate reductase DFR1 0.0012
2833 Dihydrofolate reductase Not Available 0.0012
2931 Dihydrofolate reductase folA 0.0012
3544 Dihydrofolate reductase folA 0.0012
3682 Dihydrofolate reductase folA 0.0012
6642 Dihydrofolate reductase folA 0.0012
6756 Dihydrofolate reductase dfrA 0.0012
822 Aldose reductase AKR1B1 0.0012
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