DT-Web

DB00134 - L-Methionine


Identification
Name L-Methionine
Accession Number DB00134 (NUTR00038)
Type small molecule
Description A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 149.211
Groups approved
Monoisotopic Weight 149.051049291
Pharmacology
Indication Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate.
Mechanism of action The mechanism of the possible anti-hepatotoxic activity of L-methionine is not entirely clear. It is thought that metabolism of high doses of acetaminophen in the liver lead to decreased levels of hepatic glutathione and increased oxidative stress. L-methionine is a precursor to L-cysteine. L-cysteine itself may have antioxidant activity. L-cysteine is also a precursor to the antioxidant glutathione. Antioxidant activity of L-methionine and metabolites of L-methionine appear to account for its possible anti-hepatotoxic activity. Recent research suggests that methionine itself has free-radical scavenging activity by virtue of its sulfur, as well as its chelating ability.
Absorption Absorbed from the lumen of the small intestine into the enterocytes by an active transport process.
Protein binding Not Available
Biotransformation Hepatic
Route of elimination Not Available
Toxicity Doses of L-methionine of up to 250 mg daily are generally well tolerated. Higher doses may cause nausea, vomiting and headache. Healthy adults taking 8 grams of L-methionine daily for four days were found to have reduced serum folate levels and leucocytosis. Healthy adults taking 13.9 grams of L-methionine daily for five days were found to have changes in serum pH and potassium and increased urinary calcium excretion. Schizophrenic patients given 10 to 20 grams of L-methionine daily for two weeks developed functional psychoses. Single doses of 8 grams precipitated encephalopathy in patients with cirrhosis.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • Take with food.

Targets


Methionine synthase reductase, mitochondrial
Name Methionine synthase reductase, mitochondrial
Gene Name MTRR
Pharmacological action unknown
Actions product of
References
  • Kim DJ, Park BL, Koh JM, Kim GS, Kim LH, Cheong HS, Shin HD, Hong JM, Kim TH, Shin HI, Park EK, Kim SY: Methionine synthase reductase polymorphisms are associated with serum osteocalcin levels in postmenopausal women. Exp Mol Med. 2006 Oct 31;38(5):519-24. - Pubmed
  • Tvedegaard KC, Rudiger NS, Pedersen BN, Moller J: Detection of MTRR 66A-->G polymorphism using the real-time polymerase chain reaction machine LightCycler for determination of composition of allele after restriction cleavage. Scand J Clin Lab Invest. 2006;66(8):685-93. - Pubmed
  • Elmore CL, Wu X, Leclerc D, Watson ED, Bottiglieri T, Krupenko NI, Krupenko SA, Cross JC, Rozen R, Gravel RA, Matthews RG: Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab. 2007 May;91(1):85-97. Epub 2007 Mar 21. - Pubmed
DTHybrid score 0.756
Methionine synthase
Name Methionine synthase
Gene Name MTR
Pharmacological action unknown
Actions product of
References
  • Taurog RE, Matthews RG: Activation of methyltetrahydrofolate by cobalamin-independent methionine synthase. Biochemistry. 2006 Apr 25;45(16):5092-102. - Pubmed
  • Hughes JA: In vivo hydrolysis of S-adenosyl-L-methionine in Escherichia coli increases export of 5-methylthioribose. Can J Microbiol. 2006 Jun;52(6):599-602. - Pubmed
  • Reynolds E: Vitamin B12, folic acid, and the nervous system. Lancet Neurol. 2006 Nov;5(11):949-60. - Pubmed
  • Banks EC, Doughty SW, Toms SM, Wheelhouse RT, Nicolaou A: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles. FEBS J. 2007 Jan;274(1):287-99. - Pubmed
  • Yamada K, Kawata T, Wada M, Mori K, Tamai H, Tanaka N, Tadokoro T, Tobimatsu T, Toraya T, Maekawa A: Testicular injury to rats fed on soybean protein-based vitamin B12-deficient diet can be reduced by methionine supplementation. J Nutr Sci Vitaminol (Tokyo). 2007 Apr;53(2):95-101. - Pubmed
DTHybrid score 0.7189
Methionine aminopeptidase 2
Name Methionine aminopeptidase 2
Gene Name METAP2
Pharmacological action unknown
Actions product of
References
  • Upadhya R, Zhang HS, Weiss LM: System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2006 Oct;50(10):3389-95. Epub 2006 Aug 17. - Pubmed
  • Sheppard GS, Wang J, Kawai M, Fidanze SD, BaMaung NY, Erickson SA, Barnes DM, Tedrow JS, Kolaczkowski L, Vasudevan A, Park DC, Wang GT, Sanders WJ, Mantei RA, Palazzo F, Tucker-Garcia L, Lou P, Zhang Q, Park CH, Kim KH, Petros A, Olejniczak E, Nettesheim D, Hajduk P, Henkin J, Lesniewski R, Davidsen SK, Bell RL: Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding. J Med Chem. 2006 Jun 29;49(13):3832-49. - Pubmed
  • Addlagatta A, Matthews BW: Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase. Protein Sci. 2006 Aug;15(8):1842-8. Epub 2006 Jul 5. - Pubmed
  • Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO: Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. Epub 2006 Nov 17. - Pubmed
  • Nonato MC, Widom J, Clardy J: Human methionine aminopeptidase type 2 in complex with L- and D-methionine. Bioorg Med Chem Lett. 2006 May 15;16(10):2580-3. Epub 2006 Mar 15. - Pubmed
DTHybrid score 1.9738
Betaine--homocysteine S-methyltransferase 1
Name Betaine--homocysteine S-methyltransferase 1
Gene Name BHMT
Pharmacological action unknown
Actions product of
References
  • Slow S, Garrow TA: Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats. J Nutr. 2006 Sep;136(9):2279-83. - Pubmed
  • Sparks JD, Collins HL, Chirieac DV, Cianci J, Jokinen J, Sowden MP, Galloway CA, Sparks CE: Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase. Biochem J. 2006 Apr 15;395(2):363-71. - Pubmed
  • Uthus EO, Reeves PG, Saari JT: Copper deficiency decreases plasma homocysteine in rats. J Nutr. 2007 Jun;137(6):1370-4. - Pubmed
  • Liu J, Xie Y, Cooper R, Ducharme DM, Tennant R, Diwan BA, Waalkes MP: Transplacental exposure to inorganic arsenic at a hepatocarcinogenic dose induces fetal gene expression changes in mice indicative of aberrant estrogen signaling and disrupted steroid metabolism. Toxicol Appl Pharmacol. 2007 May 1;220(3):284-91. Epub 2007 Feb 6. - Pubmed
  • Hazra A, Wu K, Kraft P, Fuchs CS, Giovannucci EL, Hunter DJ: Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study. Carcinogenesis. 2007 Jul;28(7):1510-9. Epub 2007 Mar 26. - Pubmed
DTHybrid score 1.2612
Betaine--homocysteine S-methyltransferase 2
Name Betaine--homocysteine S-methyltransferase 2
Gene Name BHMT2
Pharmacological action unknown
Actions product of
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9199

Enzymes


Glutamine synthetase
Name Glutamine synthetase
Gene Name GLUL
Actions inhibitor
References
  • Rowe WB, Meister A: Studies on the inhibition of glutamine synthetase by methionine sulfone. Biochemistry. 1973 Apr 10;12(8):1578-82. - Pubmed
  • Rowe WB, Ronzio RA, Meister A: Inhibition of glutamine synthetase by methionine sulfoximine. Studies on methionine sulfoximine phosphate. Biochemistry. 1969 Jun;8(6):2674-80. - Pubmed
  • Orr J, Haselkorn R: Regulation of glutamine synthetase activity and synthesis in free-living and symbiotic Anabaena spp. J Bacteriol. 1982 Nov;152(2):626-35. - Pubmed
DTHybrid score 0.0036
Methylenetetrahydrofolate reductase
Name Methylenetetrahydrofolate reductase
Gene Name MTHFR
Actions inhibitor
References
  • Lor KL, Cossins EA: Regulation of C metabolism by L-methionine in Saccharomyces cerevisiae. Biochem J. 1972 Dec;130(3):773-83. - Pubmed
DTHybrid score 0.6064
S-adenosylmethionine synthetase isoform type-2
Name S-adenosylmethionine synthetase isoform type-2
Gene Name MAT2A
Actions substrate
References
  • Rodriguez JL, Boukaba A, Sandoval J, Georgieva EI, Latasa MU, Garcia-Trevijano ER, Serviddio G, Nakamura T, Avila MA, Sastre J, Torres L, Mato JM, Lopez-Rodas G: Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells. Int J Biochem Cell Biol. 2007;39(4):842-50. Epub 2007 Jan 20. - Pubmed
  • Yang H, Magilnick N, Noureddin M, Mato JM, Lu SC: Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. J Cell Physiol. 2007 Mar;210(3):766-73. - Pubmed
  • Lin WC, Lin WL: Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats. World J Gastroenterol. 2006 Jan 14;12(2):265-70. - Pubmed
  • Chen H, Xia M, Lin M, Yang H, Kuhlenkamp J, Li T, Sodir NM, Chen YH, Josef-Lenz H, Laird PW, Clarke S, Mato JM, Lu SC: Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007 Jul;133(1):207-18. Epub 2007 Apr 11. - Pubmed
DTHybrid score 0.8563
Methionine-R-sulfoxide reductase B2
Name Methionine-R-sulfoxide reductase B2
Gene Name MSRB2
Actions substrate
References
  • Schallreuter KU, Rubsam K, Chavan B, Zothner C, Gillbro JM, Spencer JD, Wood JM: Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. Biochem Biophys Res Commun. 2006 Mar 31;342(1):145-52. Epub 2006 Feb 3. - Pubmed
  • Ranaivoson FM, Kauffmann B, Neiers F, Wu J, Boschi-Muller S, Panjikar S, Aubry A, Branlant G, Favier F: The X-ray structure of the N-terminal domain of PILB from Neisseria meningitidis reveals a thioredoxin-fold. J Mol Biol. 2006 Apr 28;358(2):443-54. Epub 2006 Feb 28. - Pubmed
DTHybrid score 0.9171
S-adenosylmethionine synthetase isoform type-1
Name S-adenosylmethionine synthetase isoform type-1
Gene Name MAT1A
Actions substrate
References
  • Linnebank M, Lagler F, Muntau AC, Roschinger W, Olgemoller B, Fowler B, Koch HG: Methionine adenosyltransferase (MAT) I/III deficiency with concurrent hyperhomocysteinaemia: two novel cases. J Inherit Metab Dis. 2005;28(6):1167-8. - Pubmed
  • Yang H, Magilnick N, Noureddin M, Mato JM, Lu SC: Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. J Cell Physiol. 2007 Mar;210(3):766-73. - Pubmed
  • Chen H, Xia M, Lin M, Yang H, Kuhlenkamp J, Li T, Sodir NM, Chen YH, Josef-Lenz H, Laird PW, Clarke S, Mato JM, Lu SC: Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007 Jul;133(1):207-18. Epub 2007 Apr 11. - Pubmed
  • Rodriguez JL, Boukaba A, Sandoval J, Georgieva EI, Latasa MU, Garcia-Trevijano ER, Serviddio G, Nakamura T, Avila MA, Sastre J, Torres L, Mato JM, Lopez-Rodas G: Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells. Int J Biochem Cell Biol. 2007;39(4):842-50. Epub 2007 Jan 20. - Pubmed
  • Prudova A, Bauman Z, Braun A, Vitvitsky V, Lu SC, Banerjee R: S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6489-94. Epub 2006 Apr 13. - Pubmed
DTHybrid score 1.4462
Methionine-R-sulfoxide reductase
Name Methionine-R-sulfoxide reductase
Gene Name SEPX1
Actions substrate
References
  • Kim HY, Gladyshev VN: Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases. BMC Mol Biol. 2006 Mar 16;7:11. - Pubmed
  • Kim HY, Fomenko DE, Yoon YE, Gladyshev VN: Catalytic advantages provided by selenocysteine in methionine-S-sulfoxide reductases. Biochemistry. 2006 Nov 21;45(46):13697-704. - Pubmed
DTHybrid score 0.9175
Peptide methionine sulfoxide reductase
Name Peptide methionine sulfoxide reductase
Gene Name MSRA
Actions substrate
References
  • Schallreuter KU, Rubsam K, Chavan B, Zothner C, Gillbro JM, Spencer JD, Wood JM: Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. Biochem Biophys Res Commun. 2006 Mar 31;342(1):145-52. Epub 2006 Feb 3. - Pubmed
  • Su Z, Limberis J, Martin RL, Xu R, Kolbe K, Heinemann SH, Hoshi T, Cox BF, Gintant GA: Functional consequences of methionine oxidation of hERG potassium channels. Biochem Pharmacol. 2007 Sep 1;74(5):702-11. Epub 2007 Jun 7. - Pubmed
  • Oien DB, Moskovitz J: Ablation of the mammalian methionine sulfoxide reductase A affects the expression level of cysteine deoxygenase. Biochem Biophys Res Commun. 2007 Jan 12;352(2):556-9. Epub 2006 Nov 20. - Pubmed
  • Rouhier N, Vieira Dos Santos C, Tarrago L, Rey P: Plant methionine sulfoxide reductase A and B multigenic families. Photosynth Res. 2006 Sep;89(2-3):247-62. Epub 2006 Sep 22. - Pubmed
  • Gand A, Antoine M, Boschi-Muller S, Branlant G: Characterization of the amino acids involved in substrate specificity of methionine sulfoxide reductase A. J Biol Chem. 2007 Jul 13;282(28):20484-91. Epub 2007 May 11. - Pubmed
DTHybrid score 0.7218
Methionyl-tRNA synthetase, cytoplasmic
Name Methionyl-tRNA synthetase, cytoplasmic
Gene Name MARS
Actions substrate
References
  • Chwatko G, Boers GH, Strauss KA, Shih DM, Jakubowski H: Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice. FASEB J. 2007 Jun;21(8):1707-13. Epub 2007 Feb 27. - Pubmed
  • Jakubowski H: Pathophysiological consequences of homocysteine excess. J Nutr. 2006 Jun;136(6 Suppl):1741S-1749S. - Pubmed
  • Vaughan MD, Sampson PB, Daub E, Honek JF: Investigation of bioisosteric effects on the interaction of substrates/ inhibitors with the methionyl-tRNA synthetase from Escherichia coli. Med Chem. 2005 May;1(3):227-37. - Pubmed
DTHybrid score 0.9163
Methionyl-tRNA synthetase, mitochondrial
Name Methionyl-tRNA synthetase, mitochondrial
Gene Name MARS2
Actions substrate
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Spencer AC, Heck A, Takeuchi N, Watanabe K, Spremulli LL: Characterization of the human mitochondrial methionyl-tRNA synthetase. Biochemistry. 2004 Aug 3;43(30):9743-54. - Pubmed
DTHybrid score 0.9164
Methionine adenosyltransferase 2 subunit beta
Name Methionine adenosyltransferase 2 subunit beta
Gene Name MAT2B
Actions substrate
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • LeGros L, Halim AB, Chamberlin ME, Geller A, Kotb M: Regulation of the human MAT2B gene encoding the regulatory beta subunit of methionine adenosyltransferase, MAT II. J Biol Chem. 2001 Jul 6;276(27):24918-24. Epub 2001 May 3. - Pubmed
DTHybrid score 0.9167

Transporters


Monocarboxylate transporter 10
Name Monocarboxylate transporter 10
Gene Name SLC16A10
Actions inhibitor
References
  • Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. - Pubmed
DTHybrid score 0.6646

Predictions


Id Partner name Gene Name Score
2935 Methionine synthase metH 0.7189
507 Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial MMAB 0.1907
3916 Methylmalonic aciduria and homocystinuria type C protein MMACHC 0.1906
376 Amnionless protein AMN 0.1906
398 Transcobalamin-2 TCN2 0.1906
354 Methylmalonic aciduria type A protein, mitochondrial MMAA 0.1906
265 Transcobalamin-1 TCN1 0.1906
854 Methylmalonyl-CoA mutase, mitochondrial MUT 0.1905
1224 Cubilin CUBN 0.1904
330 Spermidine synthase SRM 0.151
3038 Spermidine synthase speE 0.151
411 Glycine N-methyltransferase GNMT 0.1172
358 Cystathionine beta-synthase CBS 0.1151
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.1019
4829 Transcriptional regulator, HTH_3 family VC_1968 0.0927
3810 Catechol O-methyltransferase COMT 0.0694
6621 Methionine aminopeptidase 1 METAP1 0.0609
6013 Cytochrome P450 2E1 CYP2E1 0.054
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0446
2314 Triosephosphate isomerase TPI 0.0444
3417 Triosephosphate isomerase tpiA 0.0444
3443 Triosephosphate isomerase tpiA 0.0444
6346 Triosephosphate isomerase TPI1 0.0444
1566 Corticoliberin CRH 0.0413
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0408
5669 50S ribosomal protein L27 rpmA 0.0366
5675 Chaperone protein torD torD 0.0366
5670 Organic hydroperoxide resistance protein ohr 0.0365
5676 Axin-1 AXIN1 0.0365
5672 Molybdenum cofactor biosynthesis protein A moaA 0.0365
5410 Unsaturated glucuronyl hydrolase ugl 0.0365
5673 C protein alpha-antigen bca 0.0365
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0353
408 Riboflavin kinase RFK 0.0341
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0339
5698 Riboflavin synthase alpha chain ribE 0.0336
3763 5,10-methylenetetrahydrofolate reductase metF 0.0332
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0332
5094 5,10-methylenetetrahydrofolate reductase metF 0.0332
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0328
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0324
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.032
59 AMT protein AMT 0.032
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.032
85 Growth hormone receptor GHR 0.0319
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0314
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0314
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0314
2636 Shikimate dehydrogenase aroE 0.0313
3515 Shikimate dehydrogenase aroE 0.0313
6579 Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A 0.0313
1729 Solute carrier family 22 member 6 SLC22A6 0.0302
2280 Listeriolysin regulatory protein prfA 0.0293
314 System N amino acid transporter 1 SLC38A3 0.0293
3191 Histidinol dehydrogenase hisD 0.0292
909 Maleylacetoacetate isomerase GSTZ1 0.0288
4811 Amylosucrase ams 0.0287
2532 Pantoate--beta-alanine ligase panC 0.0285
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0282
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.028
244 Angiotensin-converting enzyme ACE 0.0267
5682 Ribonuclease pancreatic RNASE1 0.0265
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0261
461 Glycine receptor subunit alpha-3 GLRA3 0.026
820 Glycine receptor subunit alpha-2 GLRA2 0.026
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0259
199 Monocarboxylate transporter 8 SLC16A2 0.0258
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0252
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0252
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0252
3879 Serine hydroxymethyltransferase 2 Not Available 0.0252
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0252
3884 SHMT2 protein SHMT2 0.0252
3901 SHMT2 protein SHMT2 0.0252
13 Aminomethyltransferase, mitochondrial AMT 0.0246
6645 D-amino-acid oxidase DAO 0.0245
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0242
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0237
611 Retinal dehydrogenase 1 ALDH1A1 0.0232
5925 Neuropeptide Y NPY 0.0231
293 Gamma-glutamyl hydrolase GGH 0.0216
654 Flavin reductase BLVRB 0.0214
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0213
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0213
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0209
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0208
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0208
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0204
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0202
4069 Threonyl-tRNA synthetase, mitochondrial TARS2 0.0197
261 Threonyl-tRNA synthetase, cytoplasmic TARS 0.0197
246 Valyl-tRNA synthetase VARS 0.0196
263 Neutral amino acid transporter B(0) SLC1A5 0.0189
763 Tyrosine aminotransferase TAT 0.0189
5493 Tyrosine aminotransferase Not Available 0.0189
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0188
587 Serum albumin ALB 0.0185
413 Amidophosphoribosyltransferase PPAT 0.0184
2515 Amidophosphoribosyltransferase purF 0.0184
3714 Amidophosphoribosyltransferase purF 0.0184
466 Solute carrier family 12 member 3 SLC12A3 0.0184
1650 Heme carrier protein 1 SLC46A1 0.0182
718 Folate receptor gamma FOLR3 0.0178
804 Mitochondrial folate transporter/carrier SLC25A32 0.0178
299 Folate receptor beta FOLR2 0.0178
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0178
23 D(1A) dopamine receptor DRD1 0.0177
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0172
6024 Cytochrome P450 1A1 CYP1A1 0.017
5469 Head decoration protein shp 0.0168
318 Alpha-2A adrenergic receptor ADRA2A 0.0168
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0166
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0165
6142 Solute carrier family 22 member 8 SLC22A8 0.0164
2457 Bacillolysin nprS 0.016
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.016
556 Alpha-1A adrenergic receptor ADRA1A 0.0157
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.0157
2164 Multidrug resistance-associated protein 4 ABCC4 0.0155
3941 Amine oxidase [flavin-containing] A MAOA 0.0154
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0153
468 Cytochrome P450 4A11 CYP4A11 0.0152
534 Threonine synthase-like 1 THNSL1 0.0152
1024 Solute carrier family 22 member 11 SLC22A11 0.0151
676 Tyrosine 3-monooxygenase TH 0.0149
465 Calmodulin CALM1 0.0149
295 Carbonic anhydrase 1 CA1 0.0149
815 Histidyl-tRNA synthetase, cytoplasmic HARS 0.0147
96 Histidine ammonia-lyase HAL 0.0147
6257 Histidine ammonia-lyase Not Available 0.0147
6536 Histidine ammonia-lyase hutH 0.0147
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0147
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0147
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0144
159 Penicillin-binding protein 2B penA 0.0143
6121 Penicillin-binding protein 2B penA 0.0143
502 5-hydroxytryptamine 2A receptor HTR2A 0.0142
38 Cystinosin CTNS 0.0141
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0141
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0141
150 Cationic amino acid transporter 3 SLC7A3 0.0137
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0137
58 Cationic amino acid transporter 4 SLC7A4 0.0137
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0134
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0133
5 Glutaminase liver isoform, mitochondrial GLS2 0.0133
917 Glutaminase kidney isoform, mitochondrial GLS 0.0133
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0133
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0133
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0133
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0133
5261 Phosphoribosylformylglycinamidine synthase purL 0.0133
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0131
399 Tyrosyl-tRNA synthetase, mitochondrial YARS2 0.0127
6106 Cytochrome P450 2C18 CYP2C18 0.0126
2452 Tryptophanyl-tRNA synthetase trpS 0.0126
738 Monocarboxylate transporter 1 SLC16A1 0.0125
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0122
3977 ASRGL1 protein ASRGL1 0.0121
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0119
33 Cystine/glutamate transporter SLC7A11 0.0117
3 Histidine decarboxylase HDC 0.0117
357 Carbonic anhydrase 2 CA2 0.0116
349 Serine--pyruvate aminotransferase AGXT 0.0115
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0114
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0112
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0112
1008 CTP synthase 1 CTPS 0.0112
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0112
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0112
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0112
3989 Glutaminyl-tRNA synthetase QARS 0.0112
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0112
701 Isoleucine-tRNA synthetase IARS 0.011
448 Vitamin K-dependent gamma-carboxylase GGCX 0.011
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.011
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.011
4226 Uridine phosphorylase 2 UPP2 0.011
221 Lysyl-tRNA synthetase KARS 0.0109
3923 Cholinesterase BCHE 0.0108
4092 Probable asparaginyl-tRNA synthetase, mitochondrial NARS2 0.0107
669 Asparaginyl-tRNA synthetase, cytoplasmic NARS 0.0107
400 Coagulation factor IX F9 0.0107
5461 Coagulation factor IX F9 0.0107
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0106
5650 NimA-related protein DR_0842 0.0101
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.01
604 Vitamin K-dependent protein Z PROZ 0.01
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0099
5590 N utilization substance protein B homolog nusB 0.0099
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0099
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0099
2300 Lysozyme E 0.0099
3633 Lysozyme R 0.0099
5597 Lysozyme 17 0.0099
5588 Cell division protein FtsY TM_0570 0.0099
5591 Complement component C8 gamma chain C8G 0.0099
2838 Ribose-5-phosphate isomerase A rpiA 0.0099
2952 Ribose-5-phosphate isomerase A rpiA 0.0099
5595 Ribose-5-phosphate isomerase A rpiA 0.0099
4695 UPF0124 protein yfiH yfiH 0.0099
4238 50S ribosomal protein L4 rplD 0.0099
5578 50S ribosomal protein L4 rplD 0.0099
6173 50S ribosomal protein L4 rplD 0.0099
6219 50S ribosomal protein L4 rplD 0.0099
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0099
5587 Iron(III)-binding periplasmic protein fbpA 0.0099
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0099
5600 Pyruvate decarboxylase pdc 0.0099
5582 Regulator of transcription; stringent starvation protein A sspA 0.0099
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0099
5593 Transferase Not Available 0.0099
5581 Beta-fructosidase bfrA 0.0099
5060 Intron-associated endonuclease 1 ITEVIR 0.0099
4375 Glutamine synthetase 1 glnA1 0.0099
5575 Short tail fiber protein 12 0.0099
5574 Invasin YPTB1668 0.0099
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.0099
5580 Hexon protein PII 0.0099
501 Leucine carboxyl methyltransferase 1 LCMT1 0.0097
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0097
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0097
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0097
2697 Uridine-cytidine kinase 2 UCK2 0.0096
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0096
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0096
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0096
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0096
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0096
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0095
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0095
24 Thymidylate synthase TMP1 0.0094
359 Thymidylate synthase TYMS 0.0094
2626 Thymidylate synthase thyA 0.0094
2729 Thymidylate synthase thyA 0.0094
5352 Thymidylate synthase THYA 0.0094
6020 Aldehyde oxidase AOX1 0.0094
4225 Uridine phosphorylase 1 UPP1 0.0094
482 Glycine receptor subunit alpha-1 GLRA1 0.0093
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0093
828 Phenylalanine-4-hydroxylase PAH 0.0092
3109 Phenylalanine-4-hydroxylase phhA 0.0092
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0091
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0091
4992 Cytochrome c peroxidase Not Available 0.0091
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.009
1245 Vitamin K-dependent protein S PROS1 0.009
422 Vitamin K-dependent protein C PROC 0.009
6 Coagulation factor XIII A chain F13A1 0.0089
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0089
5006 RNASE4 protein RNASE4 0.0088
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0087
2555 Pol polyprotein pol 0.0087
3242 Pol polyprotein gag-pol 0.0087
3471 Pol polyprotein gag-pro-pol 0.0087
5256 Pol polyprotein pol 0.0087
6469 Pol polyprotein gag-pol 0.0087
6565 Pol polyprotein Not Available 0.0087
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0087
500 Monocarboxylate transporter 4 SLC16A3 0.0087
489 Monocarboxylate transporter 2 SLC16A7 0.0086
4533 Glyoxalase family protein BC_1747 0.0086
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0086
3132 Tryptophan synthase alpha chain trpA 0.0085
6568 Tryptophan synthase alpha chain trpA 0.0085
3729 Citrate synthase gltA 0.0085
4575 Citrate synthase cit 0.0085
4580 Citrate synthase gltA 0.0085
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0085
5328 Prostaglandin F synthase Tb11.02.2310 0.0085
6016 Cytochrome P450 2C19 CYP2C19 0.0084
5718 Cytochrome P450 2A6 CYP2A6 0.0083
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0082
169 Cysteine desulfurase, mitochondrial NFS1 0.0081
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0081
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.008
6143 Solute carrier family 22 member 7 SLC22A7 0.008
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.008
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.008
2149 Angiogenin ANG 0.008
2603 Beta-lactamase II blm 0.008
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0079
3583 6-phosphogluconolactonase pgl 0.0079
207 Glutathione synthetase GSS 0.0078
5269 Glutathione synthetase gshB 0.0078
2521 Cell division protein ftsZ ftsZ 0.0078
3301 Cell division protein ftsZ ftsZ 0.0078
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0077
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0077
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0076
184 L-serine dehydratase SDS 0.0076
431 Serine racemase SRR 0.0076
491 Serine palmitoyltransferase 1 SPTLC1 0.0076
727 Serine palmitoyltransferase 2 SPTLC2 0.0076
2286 Isocitrate dehydrogenase [NADP] icd 0.0075
2302 Isocitrate dehydrogenase [NADP] icd 0.0075
2771 Isocitrate dehydrogenase [NADP] icd 0.0075
3486 Fumarate hydratase class II fumC 0.0075
833 Organic cation/carnitine transporter 1 SLC22A4 0.0075
2942 Sialidase nanH 0.0074
3546 Sialidase nedA 0.0074
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0074
3639 Thymidine phosphorylase deoA 0.0073
3936 Thymidine phosphorylase TYMP 0.0073
90 Tryptophan 5-hydroxylase 2 TPH2 0.0073
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0073
857 Malate dehydrogenase, mitochondrial MDH2 0.0071
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0071
798 Osteocalcin BGLAP 0.0071
332 Beta-lactamase blaZ 0.0071
2478 Beta-lactamase ampC 0.0071
2613 Beta-lactamase ampC 0.0071
2635 Beta-lactamase ampC 0.0071
2700 Beta-lactamase penP 0.0071
5445 Beta-lactamase blaB 0.0071
6019 Beta-lactamase SHV-7 0.0071
6701 Beta-lactamase cphA 0.0071
5818 Folate receptor alpha FOLR1 0.0071
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.007
4512 Cytochrome P450 3A4 CYP3A4 0.007
1123 Eosinophil cationic protein RNASE3 0.007
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.007
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0068
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0067
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0067
735 Alanine aminotransferase 1 GPT 0.0067
3904 Alanine aminotransferase 2 GPT2 0.0067
740 Argininosuccinate synthase ASS1 0.0067
865 Argininosuccinate synthase ASS1 0.0067
2680 Argininosuccinate synthase argG 0.0067
3194 Argininosuccinate synthase argG 0.0067
4200 Cytochrome P450 1A2 CYP1A2 0.0066
594 Thyroxine-binding globulin SERPINA7 0.0066
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0066
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0065
5579 Carboxypeptidase B CPB1 0.0064
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0062
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0062
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0062
3384 Macrophage migration inhibitory factor MIF 0.0062
369 Coagulation factor VII F7 0.0062
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0061
758 Thyroid hormone receptor alpha THRA 0.0061
6136 Multidrug resistance-associated protein 5 ABCC5 0.006
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0059
765 Indoleamine 2,3-dioxygenase IDO1 0.0059
532 Neutral amino acid transporter A SLC1A4 0.0057
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0057
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0057
128 Adenine phosphoribosyltransferase APRT 0.0057
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0056
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0056
1671 Excitatory amino acid transporter 3 SLC1A1 0.0056
134 Tryptophan 5-hydroxylase 1 TPH1 0.0055
3877 Growth-inhibiting protein 18 GIG18 0.0054
346 Thyroid hormone receptor beta-1 THRB 0.0054
6012 Tryptophan 2,3-dioxygenase TDO2 0.0053
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0053
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0053
171 Cysteine dioxygenase CDO-1 0.0053
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0052
1314 Thiamine transporter 2 SLC19A3 0.0052
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0052
426 Aspartate aminotransferase, mitochondrial GOT2 0.0052
834 Arginase-2, mitochondrial ARG2 0.0051
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0051
3947 Xanthine dehydrogenase/oxidase XDH 0.005
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.005
4924 Cytochrome P450 2C8 CYP2C8 0.0049
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0049
577 Argininosuccinate lyase ASL 0.0049
499 Arginine decarboxylase ADC 0.0049
822 Aldose reductase AKR1B1 0.0048
239 Coagulation factor X F10 0.0046
6141 Sodium/bile acid cotransporter SLC10A1 0.0046
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0045
1588 Multidrug resistance protein 1 ABCB1 0.0045
5293 Shikimate kinase 2 aroL 0.0044
5266 Activator of hgdC 0.0044
5287 Signaling protein Not Available 0.0044
5288 Shikimate kinase aroK 0.0044
5304 UPF0166 protein TM_0021 TM_0021 0.0044
5292 Putative partitioning protein TT_C1605 0.0044
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0044
3199 Phosphopantetheine adenylyltransferase coaD 0.0044
3543 Phosphopantetheine adenylyltransferase coaD 0.0044
3567 Phosphopantetheine adenylyltransferase coaD 0.0044
5289 Phosphopantetheine adenylyltransferase coaD 0.0044
5283 D-alanine--D-alanine ligase B ddlB 0.0044
5281 Plasmid segregation protein parM parM 0.0044
5276 Chromosomal replication initiator protein dnaA dnaA 0.0044
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0044
5259 Transcriptional regulator ntrC1 0.0044
6699 Transcriptional regulator Cgl2612 0.0044
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0044
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0044
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0044
5291 Glycogen synthase 1 glgA1 0.0044
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0044
2874 Nitrogenase iron protein 1 nifH1 0.0044
4346 Polynucleotide kinase pseT 0.0044
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0044
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0044
5308 Preprotein translocase secA 1 subunit secA1 0.0044
5285 Kinesin heavy chain KIF5B 0.0044
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0044
5299 D-alanine--D-alanine ligase ddl 0.0044
6598 D-alanine--D-alanine ligase ddl 0.0044
5284 Large T antigen Not Available 0.0044
5315 Chaperone protein htpG htpG 0.0044
5277 Preprotein translocase subunit secA secA 0.0044
5264 DNA replication protein REP 0.0044
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0044
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0043
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.0043
435 Kynureninase KYNU 0.0041
4654 Kynureninase kynU 0.0041
397 Monocarboxylate transporter 3 SLC16A8 0.0041
218 Monocarboxylate transporter 5 SLC16A4 0.0041
195 Monocarboxylate transporter 7 SLC16A6 0.0041
429 Monocarboxylate transporter 6 SLC16A5 0.0041
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0041
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0041
4026 Aspartyl aminopeptidase DNPEP 0.0041
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0041
1047 Excitatory amino acid transporter 2 SLC1A2 0.0041
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0041
926 Metabotropic glutamate receptor 7 GRM7 0.0041
4016 Excitatory amino acid transporter 5 SLC1A7 0.0041
4019 Excitatory amino acid transporter 4 SLC1A6 0.0041
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0041
1912 Excitatory amino acid transporter 1 SLC1A3 0.0041
927 Metabotropic glutamate receptor 8 GRM8 0.0041
4017 5-oxoprolinase OPLAH 0.0041
664 Glutamate decarboxylase 2 GAD2 0.0041
3890 Glutamate decarboxylase 2 GAD2 0.0041
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0041
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0041
922 Glutamate receptor 4 GRIA4 0.0041
4018 Glutamate receptor delta-2 subunit GRID2 0.0041
925 Metabotropic glutamate receptor 4 GRM4 0.0041
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0041
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0041
4020 Glutamyl aminopeptidase ENPEP 0.0041
4027 Glutamate receptor delta-1 subunit GRID1 0.0041
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0041
89 Cysteine sulfinic acid decarboxylase CSAD 0.004
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.004
373 Transthyretin TTR 0.004
626 Cysteine dioxygenase type 1 CDO1 0.004
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0039
54 Prothrombin F2 0.0038
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0037
3175 Glutamate--cysteine ligase gshA 0.0037
3426 Glutamine synthetase glnA 0.0036
4106 Guanylate kinase GUK1 0.0036
4516 Guanylate kinase gmk 0.0036
4837 Cag-alfa cag-alfa 0.0036
6277 Heat shock cognate 71 kDa protein HSPA8 0.0036
4774 NTPase P4 Not Available 0.0036
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0036
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0036
5302 TrwB trwB 0.0036
5265 FtsH ftsH 0.0036
4839 DNA polymerase III subunit tau dnaX 0.0036
5646 Galactokinase GALK1 0.0036
4838 PMS1 protein homolog 2 PMS2 0.0036
5189 Trimethylamine dehydrogenase tmd 0.0036
2270 Dephospho-CoA kinase coaE 0.0036
2284 Adenylate kinase adk 0.0036
2296 Adenylate kinase adk 0.0036
2311 Adenylate kinase adk 0.0036
2312 Adenylate kinase Not Available 0.0036
3470 Hypothetical protein MG245 homolog MPN_348 0.0036
6148 Multidrug resistance-associated protein 7 ABCC10 0.0036
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0036
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0036
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0036
52 Pyruvate kinase isozymes R/L PKLR 0.0035
868 Cystathionine gamma-lyase CTH 0.0035
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0035
4085 Peptidyl-prolyl cis-trans isomerase C PPIC 0.0035
4088 Probable prolyl-tRNA synthetase, mitochondrial PARS2 0.0035
4083 Peptidyl-prolyl cis-trans isomerase H PPIH 0.0035
4087 Pyrroline 5-carboxylate reductase isoform P5CR2 0.0035
4090 Chromosome 14 open reading frame 149 C14orf149 0.0035
4082 Proline oxidase, mitochondrial PRODH 0.0035
797 Sodium-dependent proline transporter SLC6A7 0.0035
4086 Peptidyl-prolyl cis-trans isomerase G PPIG 0.0035
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0034
771 Pyruvate carboxylase, mitochondrial PC 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0034
625 Glutamate carboxypeptidase 2 FOLH1 0.0034
2683 Mono-ADP-ribosyltransferase C3 C3 0.0034
4757 Cytochrome P450 2C9 CYP2C9 0.0034
665 Phosphoserine aminotransferase PSAT1 0.0033
4652 Phosphoserine aminotransferase serC 0.0033
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0033
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0033
420 Glutamate decarboxylase 1 GAD1 0.0033
3900 Glutamate decarboxylase 1 GAD1 0.0033
340 Apoptotic protease-activating factor 1 APAF1 0.0033
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0033
2390 Nonsecretory ribonuclease RNASE2 0.0033
5312 Kinesin-like protein KIF1A KIF1A 0.0033
5300 Antigen peptide transporter 1 TAP1 0.0032
2922 Glycerol kinase glpK 0.0032
365 Dihydrofolate reductase DHFR 0.0032
2381 Dihydrofolate reductase DFR1 0.0032
2833 Dihydrofolate reductase Not Available 0.0032
2931 Dihydrofolate reductase folA 0.0032
3544 Dihydrofolate reductase folA 0.0032
3682 Dihydrofolate reductase folA 0.0032
6642 Dihydrofolate reductase folA 0.0032
6756 Dihydrofolate reductase dfrA 0.0032
163 D(1B) dopamine receptor DRD5 0.0032
5271 Focal adhesion kinase 1 PTK2 0.0032
916 Metabotropic glutamate receptor 1 GRM1 0.0032
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0032
2632 Adenylosuccinate synthetase purA 0.0031
3323 Adenylosuccinate synthetase purA 0.0031
3975 Adenylosuccinate synthetase ADSS 0.0031
4598 Adenylosuccinate synthetase Adss 0.0031
6817 Adenylosuccinate synthetase purA 0.0031
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.0031
533 Aminoacylase-1 ACY1 0.0031
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.0031
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.0031
209 Aspartoacylase ASPA 0.0031
3979 Aspartoacylase-2 ACY3 0.0031
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.0031
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.0031
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.0031
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.0031
2282 Protein recA recA 0.0031
2315 Protein recA recA 0.0031
2332 Protein recA recA 0.0031
5263 Protein recA recA 0.0031
923 Glutamate receptor 3 GRIA3 0.0031
432 D(4) dopamine receptor DRD4 0.003
2615 Chemotaxis protein cheA cheA 0.003
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.003
2371 Pantothenate kinase coaA 0.003
2892 Acetylglutamate kinase argB 0.003
3550 Acetylglutamate kinase argB 0.003
1881 Hexokinase-1 HK1 0.003
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.003
3669 Ribokinase rbsK 0.003
825 Arsenical pump-driving ATPase ASNA1 0.003
3435 Arsenical pump-driving ATPase arsA 0.003
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.003
788 Creatine kinase M-type CKM 0.003
638 D(3) dopamine receptor DRD3 0.0029
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0029
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0029
7 Nitric oxide synthase, inducible NOS2 0.0029
2727 S-adenosylmethionine synthetase metK 0.0029
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0029
291 Nitric-oxide synthase, endothelial NOS3 0.0029
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0028
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0028
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0028
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0028
862 Multidrug resistance-associated protein 1 ABCC1 0.0028
2334 Dethiobiotin synthetase bioD 0.0027
6555 Dethiobiotin synthetase bioD 0.0027
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0027
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0027
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0027
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0027
2554 Peptidyl-prolyl cis-trans isomerase, mitochondrial PPIF 0.0027
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0026
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0026
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0026
705 Glutamate receptor 1 GRIA1 0.0026
48 Pyridoxal kinase PDXK 0.0026
789 Alpha-1D adrenergic receptor ADRA1D 0.0026
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0026
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0025
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0025
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0025
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0025
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0025
702 UMP-CMP kinase CMPK1 0.0025
2091 Endoplasmin HSP90B1 0.0025
378 Alpha-2C adrenergic receptor ADRA2C 0.0025
2251 Thymidylate kinase tmk 0.0025
2254 Thymidylate kinase DTYMK 0.0025
3522 Thymidylate kinase tmk 0.0025
6395 Myosin-14 MYH14 0.0025
831 D(2) dopamine receptor DRD2 0.0024
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0024
629 Alpha-2B adrenergic receptor ADRA2B 0.0024
118 Organic cation/carnitine transporter 2 SLC22A5 0.0024
193 Beta-1 adrenergic receptor ADRB1 0.0024
1422 Serine/threonine-protein kinase 6 AURKA 0.0024
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0023
766 Beta-2 adrenergic receptor ADRB2 0.0023
3379 Kinesin-like protein KIF11 KIF11 0.0023
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0023
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0023
632 Alpha-1B adrenergic receptor ADRA1B 0.0023
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0023
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0023
3822 Actin, alpha skeletal muscle ACTA1 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0022
4057 Glycine N-acyltransferase GLYAT 0.0022
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0022
4056 N-arachidonyl glycine receptor GPR18 0.0022
4061 Peroxisomal sarcosine oxidase PIPOX 0.0022
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0022
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0022
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0022
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0022
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0022
1466 Glycyl-tRNA synthetase GARS 0.0022
509 Thymidine kinase TK 0.0022
570 Thymidine kinase TK 0.0022
2559 Thymidine kinase TK 0.0022
3430 Thymidine kinase tdk 0.0022
3518 Thymidine kinase TK 0.0022
5301 Thymidine kinase tdk 0.0022
5771 Thymidine kinase ORF36 0.0022
7009 Thymidine kinase ORF36 0.0022
5294 Nucleoside diphosphate kinase A NME1 0.0021
1721 Glycogen synthase kinase-3 beta GSK3B 0.0021
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0021
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.002
4773 Deoxycytidine kinase DCK 0.002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.002
921 Glutamate receptor 2 GRIA2 0.0018
4119 Cytochrome P450 2D6 CYP2D6 0.0018
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0018
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0017
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0017
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0017
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0017
62 Glycine receptor subunit beta GLRB 0.0017
383 Glycine amidinotransferase, mitochondrial GATM 0.0016
↑