DT-Web

DB03496 - Flavopiridol


Identification
Name Flavopiridol
Accession Number DB03496 (EXPT00998)
Type small molecule
Description Flavopiridol is a synthetic flavonoid based on an extract from an Indian plant for the potential treatment of cancer. It works by inhibiting cyclin-dependent kinases, arresting cell division and causing apoptosis in non-small lung cancer cells.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 401.84
Groups experimental
Monoisotopic Weight 401.103000462
Pharmacology
Indication Investigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified).
Mechanism of action Inhibits cyclin-dependent kinases, arresting cell division and causing apoptosis in non-small lung cancer cells.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Cell division protein kinase 2
Name Cell division protein kinase 2
Gene Name CDK2
Pharmacological action unknown
Actions inhibitor
References
  • Zvelebil MJ: Flavopiridol (Hoechst AG). IDrugs. 1998 Jun;1(2):241-6. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 2.3207
Cell division protein kinase 5
Name Cell division protein kinase 5
Gene Name CDK5
Pharmacological action unknown
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.5406
Cell division protein kinase 9
Name Cell division protein kinase 9
Gene Name CDK9
Pharmacological action unknown
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6586
Cell division control protein 2 homolog
Name Cell division control protein 2 homolog
Gene Name CDK1
Pharmacological action unknown
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.4507
Cell division protein kinase 6
Name Cell division protein kinase 6
Gene Name CDK6
Pharmacological action unknown
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.1875
Epidermal growth factor receptor
Name Epidermal growth factor receptor
Gene Name EGFR
Pharmacological action unknown
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.8648
D-HSCDK2
Name D-HSCDK2
Gene Name CDK2deltaT
Pharmacological action unknown
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.4528
Cell division protein kinase 4
Name Cell division protein kinase 4
Gene Name CDK4
Pharmacological action unknown
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7387
Cell division protein kinase 8
Name Cell division protein kinase 8
Gene Name CDK8
Pharmacological action unknown
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6583
Cell division protein kinase 7
Name Cell division protein kinase 7
Gene Name CDK7
Pharmacological action unknown
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6754
Glycogen phosphorylase, muscle form
Name Glycogen phosphorylase, muscle form
Gene Name PYGM
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.9046

Transporters


ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Nakanishi T, Karp JE, Tan M, Doyle LA, Peters T, Yang W, Wei D, Ross DD: Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients. Clin Cancer Res. 2003 Aug 15;9(9):3320-8. - Pubmed
  • Nakanishi T, Doyle LA, Hassel B, Wei Y, Bauer KS, Wu S, Pumplin DW, Fang HB, Ross DD: Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis. Mol Pharmacol. 2003 Dec;64(6):1452-62. - Pubmed
  • Shi Z, Parmar S, Peng XX, Shen T, Robey RW, Bates SE, Fu LW, Shao Y, Chen YM, Zang F, Chen ZS: The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance. Oncol Rep. 2009 Feb;21(2):483-9. - Pubmed
DTHybrid score 0.3782

Predictions


Id Partner name Gene Name Score
3321 Cell division control protein 2 homolog CRK2 1.4507
6340 Cyclin homolog 72 0.6157
6321 Cyclin-dependent kinase 5 activator 1 CDK5R1 0.3312
1176 Mitogen-activated protein kinase 1 MAPK1 0.2901
6235 Cyclin-A2 CCNA2 0.2743
1721 Glycogen synthase kinase-3 beta GSK3B 0.2675
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.1172
4750 Protein S100-A11 S100A11 0.1088
1714 Mitogen-activated protein kinase 3 MAPK3 0.1032
4751 Mitogen-activated protein kinase 12 MAPK12 0.0949
1588 Multidrug resistance protein 1 ABCB1 0.0948
3005 Threonine-phosphate decarboxylase cobD 0.0946
2530 Protein kinase C theta type PRKCQ 0.0926
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0805
1422 Serine/threonine-protein kinase 6 AURKA 0.0777
2207 Rhodopsin RHO 0.063
4512 Cytochrome P450 3A4 CYP3A4 0.0615
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.053
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0516
4118 Cytochrome P450 3A5 CYP3A5 0.0453
4924 Cytochrome P450 2C8 CYP2C8 0.0396
6016 Cytochrome P450 2C19 CYP2C19 0.0372
4757 Cytochrome P450 2C9 CYP2C9 0.0359
862 Multidrug resistance-associated protein 1 ABCC1 0.035
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0338
4200 Cytochrome P450 1A2 CYP1A2 0.0334
587 Serum albumin ALB 0.0318
4119 Cytochrome P450 2D6 CYP2D6 0.0286
10 Glycogen phosphorylase, liver form PYGL 0.0267
6024 Cytochrome P450 1A1 CYP1A1 0.0266
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0257
5300 Antigen peptide transporter 1 TAP1 0.0229
2782 Complement C1s subcomponent C1S 0.0221
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0217
5787 Angiopoietin-1 receptor TEK 0.0207
3817 Complement C1q subcomponent subunit C C1QC 0.0202
3816 Complement C1q subcomponent subunit B C1QB 0.0202
3815 Complement C1q subcomponent subunit A C1QA 0.0202
1898 Cytochrome P450 1B1 CYP1B1 0.0202
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.02
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.02
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.02
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.02
3814 Complement C1r subcomponent C1R 0.02
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0198
2503 Phosphomannomutase/phosphoglucomutase algC 0.0197
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0191
6614 Lactase-like protein LCTL 0.0185
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0164
6107 Cytochrome P450 3A7 CYP3A7 0.0163
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0156
6030 Cytochrome P450 2B6 CYP2B6 0.0155
183 Vascular endothelial growth factor A VEGFA 0.0154
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0152
6847 Lactase-phlorizin hydrolase LCT 0.015
3101 Glucose-1-phosphatase agp 0.0148
1353 DNA topoisomerase 1 TOP1 0.0135
3552 DNA topoisomerase 1 topA 0.0135
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0135
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0134
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0127
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0127
3091 Maltodextrin phosphorylase malP 0.0126
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0124
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
776 Bile salt export pump ABCB11 0.0121
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0105
5718 Cytochrome P450 2A6 CYP2A6 0.0103
6137 Multidrug resistance-associated protein 6 ABCC6 0.0103
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0103
504 Mast/stem cell growth factor receptor KIT 0.0098
3811 Cytochrome P450 19A1 CYP19A1 0.0097
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0095
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0095
6106 Cytochrome P450 2C18 CYP2C18 0.0094
3799 Hypoxanthine phosphoribosyltransferase hpt 0.0092
3719 Inosine-5'-monophosphate dehydrogenase guaB 0.0092
6148 Multidrug resistance-associated protein 7 ABCC10 0.0092
220 Sodium channel protein type 5 subunit alpha SCN5A 0.009
117 Sterol O-acyltransferase 1 SOAT1 0.009
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.009
817 DNA topoisomerase 2-alpha TOP2A 0.0088
1729 Solute carrier family 22 member 6 SLC22A6 0.0087
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0085
6013 Cytochrome P450 2E1 CYP2E1 0.0085
2164 Multidrug resistance-associated protein 4 ABCC4 0.0084
33 Cystine/glutamate transporter SLC7A11 0.0084
118 Organic cation/carnitine transporter 2 SLC22A5 0.008
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0077
6145 Solute carrier family 22 member 1 SLC22A1 0.0076
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
4773 Deoxycytidine kinase DCK 0.0074
6142 Solute carrier family 22 member 8 SLC22A8 0.0073
2538 6-phospho-beta-glucosidase bglT bglT 0.0072
2393 Maltose-6'-phosphate glucosidase glvA 0.0072
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0072
6599 HTH-type transcriptional regulator ttgR ttgR 0.0071
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.007
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.007
228 Beta platelet-derived growth factor receptor PDGFRB 0.007
102 DNA topoisomerase I, mitochondrial TOP1MT 0.007
1881 Hexokinase-1 HK1 0.0069
6144 Solute carrier family 22 member 2 SLC22A2 0.0069
5492 Cystathionine gamma-synthase metB 0.0067
5491 Methionine gamma-lyase mdeA 0.0067
992 Protein tyrosine kinase 2 beta PTK2B 0.0067
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0066
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0064
6147 Solute carrier family 22 member 3 SLC22A3 0.0064
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0063
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0063
2439 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] otsA 0.0062
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0059
2632 Adenylosuccinate synthetase purA 0.0058
3323 Adenylosuccinate synthetase purA 0.0058
3975 Adenylosuccinate synthetase ADSS 0.0058
4598 Adenylosuccinate synthetase Adss 0.0058
6817 Adenylosuccinate synthetase purA 0.0058
4120 NADPH--cytochrome P450 reductase POR 0.0058
1024 Solute carrier family 22 member 11 SLC22A11 0.0058
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
2206 Glucose-6-phosphate isomerase GPI 0.0054
4823 L-allo-threonine aldolase TM_1744 0.0054
2758 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA 0.0054
26 Vascular endothelial growth factor receptor 3 FLT4 0.0053
20 Prostaglandin G/H synthase 1 PTGS1 0.0052
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0052
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0052
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
32 Vascular endothelial growth factor receptor 1 FLT1 0.0051
407 Vascular endothelial growth factor receptor 2 KDR 0.0051
6143 Solute carrier family 22 member 7 SLC22A7 0.0051
136 Estrogen receptor ESR1 0.005
1650 Heme carrier protein 1 SLC46A1 0.005
908 Glutathione S-transferase theta-1 GSTT1 0.0049
29 Tubulin beta-1 chain TUBB1 0.0049
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0048
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0048
449 Ornithine decarboxylase ODC1 0.0046
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0046
2539 Tubulin alpha-1 chain TUBA4A 0.0045
6824 Tyrosine-protein kinase Lyn LYN 0.0043
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0043
468 Cytochrome P450 4A11 CYP4A11 0.0043
6141 Sodium/bile acid cotransporter SLC10A1 0.0043
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0043
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0042
2599 Tyrosine-protein kinase HCK HCK 0.0042
869 Estrogen receptor beta ESR2 0.0042
6163 Copper-transporting ATPase 2 ATP7B 0.0041
6165 Copper-transporting ATPase 1 ATP7A 0.0041
2514 Phosphocarrier protein HPr ptsH 0.0041
5689 Phosphocarrier protein HPr ptsH 0.0041
3602 Anti-sigma F factor antagonist spoIIAA 0.0041
5686 Potassium voltage-gated channel subfamily C member 4 KCNC4 0.0041
349 Serine--pyruvate aminotransferase AGXT 0.0041
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0041
822 Aldose reductase AKR1B1 0.0041
904 Glutathione S-transferase P GSTP1 0.004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.004
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.004
165 FL cytokine receptor FLT3 0.004
6146 High affinity copper uptake protein 1 SLC31A1 0.004
6220 Aryl hydrocarbon receptor AHR 0.0039
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
2249 Aspartate aminotransferase aspC 0.0039
2671 Aspartate aminotransferase aspC 0.0039
5490 Aspartate aminotransferase Not Available 0.0039
3947 Xanthine dehydrogenase/oxidase XDH 0.0037
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0036
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0036
1130 Lithostathine 1 alpha REG1A 0.0036
4542 Glutaminase 1 glsA1 0.0036
4544 Glutaminase 1 glsA1 0.0036
731 HIV-1 protease HIV-1 protease 0.0036
896 Glutathione S-transferase Mu 1 GSTM1 0.0035
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0034
3917 Methylenetetrahydrofolate reductase MTHFR 0.0034
3856 Fibroblast growth factor receptor 3 FGFR3 0.0033
4318 Siroheme synthase cysG 0.0033
3119 Fimbrial protein pilE1 0.0033
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0032
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0032
70 Type-1 angiotensin II receptor AGTR1 0.0032
461 Glycine receptor subunit alpha-3 GLRA3 0.0032
293 Gamma-glutamyl hydrolase GGH 0.0031
3453 Alkaline phosphatase phoA 0.0031
1757 Myeloperoxidase MPO 0.0031
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0031
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.003
738 Monocarboxylate transporter 1 SLC16A1 0.003
756 Sex hormone-binding globulin SHBG 0.003
5923 Microtubule-associated protein tau MAPT 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
5150 Endo-1,4-beta-xylanase Y xynY 0.003
469 Annexin A1 ANXA1 0.003
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
4604 Liver carboxylesterase 1 CES1 0.0027
6136 Multidrug resistance-associated protein 5 ABCC5 0.0027
106 Cannabinoid receptor 2 CNR2 0.0027
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0027
373 Transthyretin TTR 0.0027
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0027
273 Apoptosis regulator Bcl-2 BCL2 0.0026
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0026
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0026
68 Cannabinoid receptor 1 CNR1 0.0026
4192 DNA topoisomerase 2-beta TOP2B 0.0026
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0026
2473 Tyrosine-protein kinase CSK CSK 0.0026
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
290 Prostaglandin G/H synthase 2 PTGS2 0.0026
936 Ephrin type-A receptor 2 EPHA2 0.0026
511 5-hydroxytryptamine 1F receptor HTR1F 0.0025
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0024
4341 Beta crystallin B1 CRYBB1 0.0024
4340 Hypothetical conserved protein GK2698 0.0024
6484 Hypothetical conserved protein TT_C0834 0.0024
4339 Sucrose phosphorylase sucP 0.0024
1434 Protein DJ-1 PARK7 0.0024
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0024
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0024
1760 Aminopeptidase N ANPEP 0.0024
6843 Aminopeptidase N pepN 0.0024
3941 Amine oxidase [flavin-containing] A MAOA 0.0023
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0023
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
823 Fibroblast growth factor receptor 2 FGFR2 0.0022
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0022
6182 Cytochrome P450 2J2 CYP2J2 0.0022
3810 Catechol O-methyltransferase COMT 0.0022
1618 High affinity nerve growth factor receptor NTRK1 0.0021
3421 Hydroxyethylthiazole kinase thiM 0.0021
2688 Peptide deformylase def 0.0021
2708 Peptide deformylase def 0.0021
3004 Peptide deformylase def 0.0021
4337 Peptide deformylase def 0.0021
4338 Peptide deformylase def 0.0021
5368 Peptide deformylase def 0.0021
5371 Peptide deformylase def 0.0021
6375 Peptide deformylase def 0.0021
6378 Peptide deformylase def 0.0021
6379 Peptide deformylase def 0.0021
6776 Peptide deformylase def 0.0021
6900 Peptide deformylase def 0.0021
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0021
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
3105 M-phase inducer phosphatase 2 CDC25B 0.0019
4343 Alpha-glucosidase aglA 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
824 Sodium-dependent serotonin transporter SLC6A4 0.0019
6837 Serine/threonine-protein kinase 17B STK17B 0.0018
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0018
725 5-hydroxytryptamine 1D receptor HTR1D 0.0018
2408 Tyrosine-protein kinase SYK SYK 0.0018
885 5-hydroxytryptamine 1B receptor HTR1B 0.0018
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0018
871 Glucocorticoid receptor NR3C1 0.0018
3168 Beta-lactamase OXA-1 bla 0.0018
3809 Estrogen-related receptor gamma ESRRG 0.0018
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0018
3230 Non-ATP-dependent L-selective hydantoinase lhyD 0.0018
3122 D-hydantoinase Not Available 0.0018
3145 D-hydantoinase hyuA 0.0018
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0017
275 Arachidonate 5-lipoxygenase ALOX5 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
2216 Fibroblast growth factor receptor 4 FGFR4 0.0017
6228 Nuclear receptor coactivator 1 NCOA1 0.0017
4217 Telomerase reverse transcriptase TERT 0.0017
1063 Signal transducer and activator of transcription 5B STAT5B 0.0017
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0017
6241 Nuclear receptor coactivator 2 NCOA2 0.0017
239 Coagulation factor X F10 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
2840 Beta-lactamase IMP-1 Not Available 0.0017
342 P protein [Includes: DNA-directed DNA polymerase P 0.0017
612 P protein [Includes: DNA-directed DNA polymerase P 0.0017
161 Tubulin beta chain TUBB 0.0016
312 Tubulin beta chain TUB2 0.0016
320 5-hydroxytryptamine 1A receptor HTR1A 0.0016
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0016
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0016
24 Thymidylate synthase TMP1 0.0016
359 Thymidylate synthase TYMS 0.0016
2626 Thymidylate synthase thyA 0.0016
2729 Thymidylate synthase thyA 0.0016
5352 Thymidylate synthase THYA 0.0016
4225 Uridine phosphorylase 1 UPP1 0.0016
713 Sodium-dependent dopamine transporter SLC6A3 0.0016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0015
3873 Prolyl endopeptidase PREP 0.0015
6928 Prolyl endopeptidase Not Available 0.0015
3237 Beta-lactamase OXA-2 bla 0.0015
3292 Alanine racemase, catabolic dadX 0.0015
3281 Isoaspartyl dipeptidase iadA 0.0015
4264 Alpha-L-fucosidase, putative TM_0306 0.0015
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0015
6171 Solute carrier family 28 member 3 SLC28A3 0.0015
702 UMP-CMP kinase CMPK1 0.0015
5626 Nucleoside diphosphate kinase B NME2 0.0015
6031 Cytochrome P450 3A43 CYP3A43 0.0015
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0015
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0014
484 Tyrosine-protein kinase ABL2 ABL2 0.0014
3923 Cholinesterase BCHE 0.0014
2801 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase murE 0.0014
2983 Methylmalonyl-CoA carboxyltransferase 5S subunit Not Available 0.0014
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
2320 Thymidine kinase, cytosolic TK1 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0013
4549 Endonuclease III HP_0602 0.0013
2646 Dihydroorotase pyrC 0.0013
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0013
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0013
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0013
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0013
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0013
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0013
1864 RET proto-oncogene RET 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
2717 Folylpolyglutamate synthase fgs 0.0013
789 Alpha-1D adrenergic receptor ADRA1D 0.0013
760 Fibroblast growth factor 1 FGF1 0.0013
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0013
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0013
7 Nitric oxide synthase, inducible NOS2 0.0012
5294 Nucleoside diphosphate kinase A NME1 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
2340 Beta-lactamase PSE-2 bla 0.0012
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0012
2796 Parathion hydrolase opd 0.0012
6539 Parathion hydrolase opd 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
894 Alanine racemase alr 0.0012
2453 Alanine racemase alr 0.0012
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0012
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
632 Alpha-1B adrenergic receptor ADRA1B 0.0011
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0011
489 Monocarboxylate transporter 2 SLC16A7 0.0011
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0011
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0011
3587 Gastrotropin FABP6 0.0011
5818 Folate receptor alpha FOLR1 0.001
833 Organic cation/carnitine transporter 1 SLC22A4 0.001
556 Alpha-1A adrenergic receptor ADRA1A 0.001
6149 Solute carrier family 22 member 10 SLC22A10 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
84 Nuclear receptor 0B1 NR0B1 0.001
467 Delta-type opioid receptor OPRD1 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.001
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.001
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.001
696 Kappa-type opioid receptor OPRK1 0.001
6168 Solute carrier family 22 member 16 SLC22A16 0.001
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.001
847 Mu-type opioid receptor OPRM1 0.0009
6014 Cytochrome P450 2A13 CYP2A13 0.0009
3689 Endoglucanase A celA 0.0009
5563 Galectin-2 LGALS2 0.0009
5411 Slt-IIvB stxB2e 0.0009
5046 Ecotin eco 0.0009
5554 D-galactose-binding periplasmic protein mglB 0.0009
3741 D-galactose-binding periplasmic protein precursor mglB 0.0009
3009 Beta-glucanase Not Available 0.0009
1875 Pulmonary surfactant-associated protein D SFTPD 0.0009
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0009
5568 Endoglucanase C307 celC307 0.0009
5562 Hexokinase Not Available 0.0009
3744 Endoglucanase SS precursor celS 0.0009
3793 Aspartate ammonia-lyase aspA 0.0009
5569 Endo-1,4-beta glucanase EngF engF 0.0009
5553 Endoglucanase E1 Acel_0614 0.0009
5559 Neopullulanase nplT 0.0009
4670 Cellulase B celB 0.0009
4668 Laminarinase TM_0024 0.0009
4671 Endoglucanase C cenC 0.0009
5570 Endoglucanase E-4 celD 0.0009
4667 BH0236 protein BH0236 0.0009
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0009
380 Cytochrome P450 17A1 CYP17A1 0.0008
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0008
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0008
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0008
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0008
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0008
1184 Interferon beta IFNB1 0.0008
4509 Acetoin(diacetyl) reductase budC 0.0008
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0008
5176 YtnJ moxC 0.0008
1503 Galectin-7 LGALS7 0.0008
5416 Coat protein VP1 Not Available 0.0008
5247 Endo-1,4-beta-xylanase Not Available 0.0008
5248 Endo-1,4-beta-xylanase xlnA 0.0008
5250 Endo-1,4-beta-xylanase xyl 0.0008
5498 Maltoporin lamB 0.0008
5561 Maltoporin lamB 0.0008
4622 Amylase Not Available 0.0008
2705 Dimethyl sulfoxide reductase dmsA 0.0008
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0008
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0008
4669 Endo-1,4-beta-xylanase A xynA 0.0008
4715 Endo-1,4-beta-xylanase A xlnA 0.0008
5560 Endo-1,4-beta-xylanase A xynA 0.0008
3875 Glycogen phosphorylase, brain form PYGB 0.0008
3882 Brain glycogen phosphorylase variant Not Available 0.0008
6085 Fatty acid-binding protein, intestinal FABP2 0.0008
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0007
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0007
3547 Enterotoxin type B entB 0.0007
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0007
3747 Cellulase B precursor celB 0.0007
2531 Alpha-amylase amyE 0.0007
2948 Alpha-amylase amy 0.0007
3169 Alpha-amylase Not Available 0.0007
4819 Hydrolase Not Available 0.0007
5249 Hydrolase Not Available 0.0007
5436 Hydrolase Not Available 0.0007
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0007
2324 Botulinum neurotoxin type B botB 0.0007
2606 Neopullulanase 2 tvaII 0.0007
4811 Amylosucrase ams 0.0007
2541 Neopullulanase 1 tvaI 0.0007
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0007
3887 Phosphorylase PYGB 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2826 Glucose--fructose oxidoreductase gfo 0.0007
2372 Bifunctional tail protein 9 0.0007
3225 Shiga toxin B-chain stxB 0.0007
4830 Aldose 1-epimerase galM 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
3365 Beta-amylase spoII 0.0007
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0007
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0007
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0007
3911 Uncharacterized protein C20orf38 SPTLC3 0.0007
3883 Ornithine aminotransferase variant Not Available 0.0007
306 Pyridoxal phosphate phosphatase PDXP 0.0007
3891 Putative L-Dopa decarboxylase DDC 0.0007
3881 Selenocysteine lyase variant Not Available 0.0007
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0007
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0007
3893 DDC protein DDC 0.0007
3880 Serine hydroxymethyltransferase 1 Not Available 0.0007
3906 Serine dehydratase-like SDSL 0.0007
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0007
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0007
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0007
3886 Migration-inducing protein 4 ALAS1 0.0007
3878 GAD1 protein GAD1 0.0007
664 Glutamate decarboxylase 2 GAD2 0.0007
3890 Glutamate decarboxylase 2 GAD2 0.0007
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0007
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0007
3905 Molybdenum cofactor sulfurase MOCOS 0.0007
3894 KIAA0251 protein PDXDC1 0.0007
1675 Glucokinase GCK 0.0006
4662 Glucokinase glk 0.0006
3030 Salivary alpha-amylase AMY1A 0.0006
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0006
2508 Cyclomaltodextrin glucanotransferase cgt 0.0006
2523 Cyclomaltodextrin glucanotransferase cgt 0.0006
3207 Cyclomaltodextrin glucanotransferase amyA 0.0006
868 Cystathionine gamma-lyase CTH 0.0006
472 Ornithine aminotransferase, mitochondrial OAT 0.0006
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0006
3668 Maltose-binding periplasmic protein precursor malE 0.0006
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0006
2802 Endoglucanase G celCCG 0.0006
2570 Tetanus toxin tetX 0.0006
4692 A/G-specific adenine glycosylase mutY 0.0006
435 Kynureninase KYNU 0.0006
4654 Kynureninase kynU 0.0006
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0006
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0006
6020 Aldehyde oxidase AOX1 0.0006
4272 POSSIBLE CELLULASE CELA1 celA1 0.0006
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0006
146 Androgen receptor AR 0.0006
291 Nitric-oxide synthase, endothelial NOS3 0.0006
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0006
2440 Endoglucanase F celCCF 0.0006
365 Dihydrofolate reductase DHFR 0.0006
2381 Dihydrofolate reductase DFR1 0.0006
2833 Dihydrofolate reductase Not Available 0.0006
2931 Dihydrofolate reductase folA 0.0006
3544 Dihydrofolate reductase folA 0.0006
3682 Dihydrofolate reductase folA 0.0006
6642 Dihydrofolate reductase folA 0.0006
6756 Dihydrofolate reductase dfrA 0.0006
2430 Chondroitinase B cslB 0.0006
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0006
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0006
3913 Glutamic acid decarboxylase GAD65 0.0006
184 L-serine dehydratase SDS 0.0006
431 Serine racemase SRR 0.0006
727 Serine palmitoyltransferase 2 SPTLC2 0.0006
491 Serine palmitoyltransferase 1 SPTLC1 0.0006
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0006
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0006
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0006
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0006
3 Histidine decarboxylase HDC 0.0006
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0006
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0006
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0006
665 Phosphoserine aminotransferase PSAT1 0.0006
4652 Phosphoserine aminotransferase serC 0.0006
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0006
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0006
420 Glutamate decarboxylase 1 GAD1 0.0006
3900 Glutamate decarboxylase 1 GAD1 0.0006
499 Arginine decarboxylase ADC 0.0006
534 Threonine synthase-like 1 THNSL1 0.0006
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0006
89 Cysteine sulfinic acid decarboxylase CSAD 0.0006
426 Aspartate aminotransferase, mitochondrial GOT2 0.0006
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0006
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0006
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0006
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0006
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0005
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0005
2245 Xylose isomerase xylA 0.0005
2253 Xylose isomerase xylA 0.0005
2260 Xylose isomerase xylA 0.0005
2431 Xylose isomerase xylA 0.0005
2252 Endoglucanase 5A cel5A 0.0005
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0005
2723 Cholera enterotoxin subunit B ctxB 0.0005
358 Cystathionine beta-synthase CBS 0.0005
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0005
3884 SHMT2 protein SHMT2 0.0005
3901 SHMT2 protein SHMT2 0.0005
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0005
3879 Serine hydroxymethyltransferase 2 Not Available 0.0005
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0005
3877 Growth-inhibiting protein 18 GIG18 0.0005
169 Cysteine desulfurase, mitochondrial NFS1 0.0005
2427 Ferrichrome-iron receptor fhuA 0.0005
4513 Pancreatic alpha-amylase AMY2A 0.0005
763 Tyrosine aminotransferase TAT 0.0005
5493 Tyrosine aminotransferase Not Available 0.0005
3904 Alanine aminotransferase 2 GPT2 0.0005
735 Alanine aminotransferase 1 GPT 0.0005
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0005
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0005
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0005
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0005
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0005
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0005
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0005
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0005
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