DT-Web

DB03839 - D-Tyrosine


Identification
Name D-Tyrosine
Accession Number DB03839 (EXPT01295)
Type small molecule
Description A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 181.1885
Groups experimental
Monoisotopic Weight 181.073893223
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Transporters


Monocarboxylate transporter 10
Name Monocarboxylate transporter 10
Gene Name SLC16A10
Actions inhibitor
References
  • Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. - Pubmed
DTHybrid score 0.3018

Predictions


Id Partner name Gene Name Score
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0446
1566 Corticoliberin CRH 0.0413
2532 Pantoate--beta-alanine ligase panC 0.0285
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0262
199 Monocarboxylate transporter 8 SLC16A2 0.0258
6645 D-amino-acid oxidase DAO 0.0245
5925 Neuropeptide Y NPY 0.0231
314 System N amino acid transporter 1 SLC38A3 0.0229
4069 Threonyl-tRNA synthetase, mitochondrial TARS2 0.0197
261 Threonyl-tRNA synthetase, cytoplasmic TARS 0.0197
246 Valyl-tRNA synthetase VARS 0.0196
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0183
5469 Head decoration protein shp 0.0168
763 Tyrosine aminotransferase TAT 0.0167
5493 Tyrosine aminotransferase Not Available 0.0167
2457 Bacillolysin nprS 0.016
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.0157
534 Threonine synthase-like 1 THNSL1 0.0152
676 Tyrosine 3-monooxygenase TH 0.0149
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0148
815 Histidyl-tRNA synthetase, cytoplasmic HARS 0.0147
96 Histidine ammonia-lyase HAL 0.0147
6257 Histidine ammonia-lyase Not Available 0.0147
6536 Histidine ammonia-lyase hutH 0.0147
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0147
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0147
38 Cystinosin CTNS 0.0141
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0141
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0141
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.014
150 Cationic amino acid transporter 3 SLC7A3 0.0137
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0137
58 Cationic amino acid transporter 4 SLC7A4 0.0137
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0134
399 Tyrosyl-tRNA synthetase, mitochondrial YARS2 0.0127
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0124
3977 ASRGL1 protein ASRGL1 0.0121
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0119
263 Neutral amino acid transporter B(0) SLC1A5 0.0119
3 Histidine decarboxylase HDC 0.0117
349 Serine--pyruvate aminotransferase AGXT 0.0115
701 Isoleucine-tRNA synthetase IARS 0.011
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.011
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.011
221 Lysyl-tRNA synthetase KARS 0.0109
4092 Probable asparaginyl-tRNA synthetase, mitochondrial NARS2 0.0107
669 Asparaginyl-tRNA synthetase, cytoplasmic NARS 0.0107
358 Cystathionine beta-synthase CBS 0.0106
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0103
5650 NimA-related protein DR_0842 0.0101
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.0099
33 Cystine/glutamate transporter SLC7A11 0.0098
501 Leucine carboxyl methyltransferase 1 LCMT1 0.0097
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0097
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0097
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0097
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0096
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0096
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0096
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0096
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0096
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0095
482 Glycine receptor subunit alpha-1 GLRA1 0.0093
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0093
828 Phenylalanine-4-hydroxylase PAH 0.0092
3109 Phenylalanine-4-hydroxylase phhA 0.0092
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0089
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0087
500 Monocarboxylate transporter 4 SLC16A3 0.0087
489 Monocarboxylate transporter 2 SLC16A7 0.0086
169 Cysteine desulfurase, mitochondrial NFS1 0.0081
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0077
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0076
738 Monocarboxylate transporter 1 SLC16A1 0.0076
184 L-serine dehydratase SDS 0.0076
431 Serine racemase SRR 0.0076
491 Serine palmitoyltransferase 1 SPTLC1 0.0076
727 Serine palmitoyltransferase 2 SPTLC2 0.0076
833 Organic cation/carnitine transporter 1 SLC22A4 0.0075
90 Tryptophan 5-hydroxylase 2 TPH2 0.0073
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0073
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0068
740 Argininosuccinate synthase ASS1 0.0067
865 Argininosuccinate synthase ASS1 0.0067
2680 Argininosuccinate synthase argG 0.0067
3194 Argininosuccinate synthase argG 0.0067
594 Thyroxine-binding globulin SERPINA7 0.0066
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0065
758 Thyroid hormone receptor alpha THRA 0.0061
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0059
765 Indoleamine 2,3-dioxygenase IDO1 0.0059
532 Neutral amino acid transporter A SLC1A4 0.0057
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0057
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0057
2452 Tryptophanyl-tRNA synthetase trpS 0.0056
134 Tryptophan 5-hydroxylase 1 TPH1 0.0055
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0054
346 Thyroid hormone receptor beta-1 THRB 0.0054
6012 Tryptophan 2,3-dioxygenase TDO2 0.0053
171 Cysteine dioxygenase CDO-1 0.0053
3426 Glutamine synthetase glnA 0.0052
3987 Glutamine synthetase GLUL 0.0052
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0052
1314 Thiamine transporter 2 SLC19A3 0.0052
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0052
207 Glutathione synthetase GSS 0.0052
5269 Glutathione synthetase gshB 0.0052
834 Arginase-2, mitochondrial ARG2 0.0051
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0051
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0051
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.005
577 Argininosuccinate lyase ASL 0.0049
499 Arginine decarboxylase ADC 0.0049
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0049
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0048
317 Methionine-R-sulfoxide reductase SEPX1 0.0048
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0048
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0048
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0048
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0048
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0046
6141 Sodium/bile acid cotransporter SLC10A1 0.0046
735 Alanine aminotransferase 1 GPT 0.0046
3904 Alanine aminotransferase 2 GPT2 0.0046
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0045
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0044
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.0043
435 Kynureninase KYNU 0.0041
4654 Kynureninase kynU 0.0041
397 Monocarboxylate transporter 3 SLC16A8 0.0041
218 Monocarboxylate transporter 5 SLC16A4 0.0041
195 Monocarboxylate transporter 7 SLC16A6 0.0041
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0041
429 Monocarboxylate transporter 6 SLC16A5 0.0041
191 Peptide methionine sulfoxide reductase MSRA 0.0041
89 Cysteine sulfinic acid decarboxylase CSAD 0.004
373 Transthyretin TTR 0.004
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.004
626 Cysteine dioxygenase type 1 CDO1 0.004
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0039
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0038
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0036
52 Pyruvate kinase isozymes R/L PKLR 0.0035
868 Cystathionine gamma-lyase CTH 0.0035
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0035
4085 Peptidyl-prolyl cis-trans isomerase C PPIC 0.0035
4088 Probable prolyl-tRNA synthetase, mitochondrial PARS2 0.0035
4083 Peptidyl-prolyl cis-trans isomerase H PPIH 0.0035
4087 Pyrroline 5-carboxylate reductase isoform P5CR2 0.0035
4090 Chromosome 14 open reading frame 149 C14orf149 0.0035
4082 Proline oxidase, mitochondrial PRODH 0.0035
797 Sodium-dependent proline transporter SLC6A7 0.0035
4086 Peptidyl-prolyl cis-trans isomerase G PPIG 0.0035
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0034
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0034
5 Glutaminase liver isoform, mitochondrial GLS2 0.0034
917 Glutaminase kidney isoform, mitochondrial GLS 0.0034
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0034
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0034
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0034
5261 Phosphoribosylformylglycinamidine synthase purL 0.0034
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0034
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0034
771 Pyruvate carboxylase, mitochondrial PC 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0034
6142 Solute carrier family 22 member 8 SLC22A8 0.0033
1671 Excitatory amino acid transporter 3 SLC1A1 0.0033
840 Methionine synthase reductase, mitochondrial MTRR 0.0033
163 D(1B) dopamine receptor DRD5 0.0032
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0032
3877 Growth-inhibiting protein 18 GIG18 0.0031
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0031
2632 Adenylosuccinate synthetase purA 0.0031
3323 Adenylosuccinate synthetase purA 0.0031
3975 Adenylosuccinate synthetase ADSS 0.0031
4598 Adenylosuccinate synthetase Adss 0.0031
6817 Adenylosuccinate synthetase purA 0.0031
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.0031
533 Aminoacylase-1 ACY1 0.0031
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.0031
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.0031
209 Aspartoacylase ASPA 0.0031
3979 Aspartoacylase-2 ACY3 0.0031
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.0031
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.0031
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.0031
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.0031
809 Methionine synthase MTR 0.0031
2935 Methionine synthase metH 0.0031
432 D(4) dopamine receptor DRD4 0.003
426 Aspartate aminotransferase, mitochondrial GOT2 0.003
587 Serum albumin ALB 0.003
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.003
638 D(3) dopamine receptor DRD3 0.0029
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0029
7 Nitric oxide synthase, inducible NOS2 0.0029
1008 CTP synthase 1 CTPS 0.0029
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0029
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0029
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0029
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0029
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0029
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0029
3989 Glutaminyl-tRNA synthetase QARS 0.0029
291 Nitric-oxide synthase, endothelial NOS3 0.0029
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0027
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0027
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0027
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0027
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0027
2554 Peptidyl-prolyl cis-trans isomerase, mitochondrial PPIF 0.0027
2795 Methionine aminopeptidase 2 METAP2 0.0026
23 D(1A) dopamine receptor DRD1 0.0026
3917 Methylenetetrahydrofolate reductase MTHFR 0.0026
789 Alpha-1D adrenergic receptor ADRA1D 0.0026
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0025
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0025
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0025
378 Alpha-2C adrenergic receptor ADRA2C 0.0025
1588 Multidrug resistance protein 1 ABCB1 0.0025
831 D(2) dopamine receptor DRD2 0.0024
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0024
629 Alpha-2B adrenergic receptor ADRA2B 0.0024
118 Organic cation/carnitine transporter 2 SLC22A5 0.0024
193 Beta-1 adrenergic receptor ADRB1 0.0024
6 Coagulation factor XIII A chain F13A1 0.0024
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0023
766 Beta-2 adrenergic receptor ADRB2 0.0023
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0023
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0023
632 Alpha-1B adrenergic receptor ADRA1B 0.0023
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0023
413 Amidophosphoribosyltransferase PPAT 0.0023
2515 Amidophosphoribosyltransferase purF 0.0023
3714 Amidophosphoribosyltransferase purF 0.0023
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0022
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0022
4057 Glycine N-acyltransferase GLYAT 0.0022
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0022
4056 N-arachidonyl glycine receptor GPR18 0.0022
4061 Peroxisomal sarcosine oxidase PIPOX 0.0022
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0022
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0022
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0022
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0022
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0022
1466 Glycyl-tRNA synthetase GARS 0.0022
318 Alpha-2A adrenergic receptor ADRA2A 0.0022
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0021
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.002
556 Alpha-1A adrenergic receptor ADRA1A 0.002
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.002
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0019
4119 Cytochrome P450 2D6 CYP2D6 0.0018
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0017
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0017
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0017
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0017
62 Glycine receptor subunit beta GLRB 0.0017
383 Glycine amidinotransferase, mitochondrial GATM 0.0016
411 Glycine N-methyltransferase GNMT 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
3884 SHMT2 protein SHMT2 0.0015
3901 SHMT2 protein SHMT2 0.0015
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0015
3879 Serine hydroxymethyltransferase 2 Not Available 0.0015
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0015
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
461 Glycine receptor subunit alpha-3 GLRA3 0.0014
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0014
4924 Cytochrome P450 2C8 CYP2C8 0.0013
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0011
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0011
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0011
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0011
664 Glutamate decarboxylase 2 GAD2 0.0011
3890 Glutamate decarboxylase 2 GAD2 0.0011
4026 Aspartyl aminopeptidase DNPEP 0.0011
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0011
1912 Excitatory amino acid transporter 1 SLC1A3 0.0011
4016 Excitatory amino acid transporter 5 SLC1A7 0.0011
4019 Excitatory amino acid transporter 4 SLC1A6 0.0011
4017 5-oxoprolinase OPLAH 0.0011
1047 Excitatory amino acid transporter 2 SLC1A2 0.0011
926 Metabotropic glutamate receptor 7 GRM7 0.0011
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0011
4018 Glutamate receptor delta-2 subunit GRID2 0.0011
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0011
922 Glutamate receptor 4 GRIA4 0.0011
927 Metabotropic glutamate receptor 8 GRM8 0.0011
925 Metabotropic glutamate receptor 4 GRM4 0.0011
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0011
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0011
4020 Glutamyl aminopeptidase ENPEP 0.0011
4027 Glutamate receptor delta-1 subunit GRID1 0.0011
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0009
625 Glutamate carboxypeptidase 2 FOLH1 0.0009
665 Phosphoserine aminotransferase PSAT1 0.0008
4652 Phosphoserine aminotransferase serC 0.0008
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0008
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0008
420 Glutamate decarboxylase 1 GAD1 0.0008
3900 Glutamate decarboxylase 1 GAD1 0.0008
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
916 Metabotropic glutamate receptor 1 GRM1 0.0008
923 Glutamate receptor 3 GRIA3 0.0008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0008
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0008
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0007
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0007
705 Glutamate receptor 1 GRIA1 0.0006
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0006
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0005
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0005
921 Glutamate receptor 2 GRIA2 0.0005
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