DT-Web: DB01016

Identification

Name

Glyburide

Accession Number

DB01016 (APRD00233)

Type

small molecule

Description

Glyburide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Glyburide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Glyburide appears to be completely metabolized, likely in the liver. Although its metabolites exert a small hypoglycemic effect, their contribution to glyburide's hypoglycemic effect is thought to be clinically unimportant. Glyburide metabolites are excreted in urine and feces in approximately equal proportions. The half-life of glyburide appears to be unaffected in those with a creatinine clearance of greater than 29 ml/min/1.73m².

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

494.004

Groups

approved

Monoisotopic Weight

493.143819418

Pharmacology

Indication

Indicated as an adjunct to diet to lower the blood glucose in patients with NIDDM whose hyperglycemia cannot be satisfactorily controlled by diet alone.

Mechanism of action

Sulfonylureas such as glyburide bind to ATP-sensitive potassium channels on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.

Absorption

Significant absorption within 1 hour and peak plasma levels are reached in 2 to 4 hours. Onset of action occurs within one hour.

Protein binding

Unchanged drug is ~99% bound to serum proteins; 4-trans-hydroxyglyburide is greater than 97% bound to serum proteins. Protein binding is primarily nonionic making glyburide and is less likely to displace or be displaced by drugs that bind via an ionic mechanism.

Biotransformation

Primarily hepatic (mainly cytochrome P450 3A4). The major metabolite is the 4-trans-hydroxy derivative. A second metabolite, the 3-cis-hydroxy derivative, also occurs. These metabolites do not contribute clinically significant hypoglycemic action in humans as they are only weakly active; however, retention of 4-trans-hydroxyglyburide may prolong the hypoglycemic effect of the agent in those with severe renal impairment.

Route of elimination

Glyburide is excreted as metabolites in the bile and urine, approximately 50% by each route. This dual excretory pathway is qualitatively different from that of other sulfonylureas, which are excreted primarily in the urine.

Toxicity

Oral rat LD₅₀: > 20,000 mg/kg. Oral mouse LD₅₀: 3250 mg/kg.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acebutolol	Acebutolol may decrease symptoms of hypoglycemia and increase the time required for the body to compensate for hypoglycemia.
Acetylsalicylic acid	Acetylsalicylic acid increases the effect of the sulfonylurea, glibenclamide.
Atenolol	The beta-blocker, atenolol, may decrease symptoms of hypoglycemia.
Betaxolol	The beta-blocker, betaxolol, may decrease symptoms of hypoglycemia.
Bevantolol	The beta-blocker, bevantolol, may decrease symptoms of hypoglycemia.
Bismuth Subsalicylate	The salicylate, bismuth subsalicylate, increases the effect of the sulfonylurea, glibenclamide.
Bisoprolol	The beta-blocker, bisoprolol, may decrease symptoms of hypoglycemia.
Bosentan	Increased risk of hepatic toxicity
Carteolol	The beta-blocker, carteolol, may decrease symptoms of hypoglycemia.
Carvedilol	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Chloramphenicol	Chloramphenicol may increase the effect of sulfonylurea, glibenclamide.
Clofibrate	Clofibrate may increase the effect of sulfonylurea, glibenclamide.
Colesevelam	Colesevelam may decrease the serum concentration of Glyburide. Glyburide should be administered at least 4 hours before colesevelam to minimize the risk of an interaction.
Cyclosporine	The sulfonylurea, glibenclamide, may increase the effect of cyclosporine.
Diazoxide	Antagonism.
Dicumarol	Dicumarol may increase the effect of sulfonylurea, glibenclamide.
Esmolol	The beta-blocker, esmolol, may decrease symptoms of hypoglycemia.
Glucosamine	Possible hyperglycemia
Labetalol	The beta-blocker, labetalol, may decrease symptoms of hypoglycemia.
Magnesium salicylate	The salicylate, magnesium salicylate, increases the effect of the sulfonylurea, glibenclamide.
Metoprolol	The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Nadolol	The beta-blocker, nadolol, may decrease symptoms of hypoglycemia.
Oxprenolol	The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Penbutolol	The beta-blocker, penbutolol, may decrease symptoms of hypoglycemia.
Phenylbutazone	Phenylbutazone increases the effect of the hypoglycemic agent
Pindolol	The beta-blocker, pindolol, may decrease symptoms of hypoglycemia.
Practolol	The beta-blocker, practolol, may decrease symptoms of hypoglycemia.
Propranolol	The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Rifampin	Rifampin may decrease the effect of sulfonylurea, glibenclamide.
Salicylate-sodium	The salicylate, salicylate-sodium, increases the effect of the sulfonylurea, glibenclamide.
Salsalate	The salicylate, salsalate, increases the effect of the sulfonylurea, glibenclamide.
Somatropin recombinant	Somatropin may antagonize the hypoglycemic effect of glibenclamide. Monitor for changes in fasting and postprandial blood sugars.
Sotalol	The beta-blocker, sotalol, may decrease symptoms of hypoglycemia.
Timolol	The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Trisalicylate-choline	The salicylate, trisalicylate-choline, increases the effect of the sulfonylurea, glibenclamide.

Food Interactions

Take 30-60 minutes before breakfast.
Avoid alcohol.

ATP-binding cassette transporter sub-family C member 8
Name	ATP-binding cassette transporter sub-family C member 8
Gene Name	ABCC8
Pharmacological action	yes
Actions	modulator
References	Dabrowski M, Ashcroft FM, Ashfield R, Lebrun P, Pirotte B, Egebjerg J, Bondo Hansen J, Wahl P: The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener. Diabetes. 2002 Jun;51(6):1896-906. - Pubmed Hambrock A, Preisig-Muller R, Russ U, Piehl A, Hanley PJ, Ray J, Daut J, Quast U, Derst C: Four novel splice variants of sulfonylurea receptor 1. Am J Physiol Cell Physiol. 2002 Aug;283(2):C587-98. - Pubmed Hambrock A, Loffler-Walz C, Quast U: Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides. Br J Pharmacol. 2002 Aug;136(7):995-1004. - Pubmed Nielsen FE, Bodvarsdottir TB, Worsaae A, MacKay P, Stidsen CE, Boonen HC, Pridal L, Arkhammar PO, Wahl P, Ynddal L, Junager F, Dragsted N, Tagmose TM, Mogensen JP, Koch A, Treppendahl SP, Hansen JB: 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. J Med Chem. 2002 Sep 12;45(19):4171-87. - Pubmed Babenko AP, Bryan J: SUR-dependent modulation of KATP channels by an N-terminal KIR6.2 peptide. Defining intersubunit gating interactions. J Biol Chem. 2002 Nov 15;277(46):43997-4004. Epub 2002 Sep 3. - Pubmed Ueda K, Komine J, Matsuo M, Seino S, Amachi T: Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1268-72. - Pubmed
DTHybrid score	0.6237
ATP-sensitive inward rectifier potassium channel 1
Name	ATP-sensitive inward rectifier potassium channel 1
Gene Name	KCNJ1
Pharmacological action	unknown
Actions	inhibitor
References	Pondugula SR, Raveendran NN, Ergonul Z, Deng Y, Chen J, Sanneman JD, Palmer LG, Marcus DC: Glucocorticoid regulation of genes in the amiloride-sensitive sodium transport pathway by semicircular canal duct epithelium of neonatal rat. Physiol Genomics. 2006 Jan 12;24(2):114-23. Epub 2005 Nov 1. - Pubmed Lu M, Leng Q, Egan ME, Caplan MJ, Boulpaep EL, Giebisch GH, Hebert SC: CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. J Clin Invest. 2006 Mar;116(3):797-807. Epub 2006 Feb 9. - Pubmed
DTHybrid score	0.7986
G protein-activated inward rectifier potassium channel 4
Name	G protein-activated inward rectifier potassium channel 4
Gene Name	KCNJ5
Pharmacological action	unknown
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.2098
ATP-binding cassette transporter sub-family C member 9
Name	ATP-binding cassette transporter sub-family C member 9
Gene Name	ABCC9
Pharmacological action	unknown
Actions	modulator
References	Hambrock A, Loffler-Walz C, Quast U: Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides. Br J Pharmacol. 2002 Aug;136(7):995-1004. - Pubmed Rainbow RD, James M, Hudman D, Al Johi M, Singh H, Watson PJ, Ashmole I, Davies NW, Lodwick D, Norman RI: Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels. Biochem J. 2004 Apr 1;379(Pt 1):173-81. - Pubmed Felsch H, Lange U, Hambrock A, Loffler-Walz C, Russ U, Carroll WA, Gopalakrishnan M, Quast U: Interaction of a novel dihydropyridine K+ channel opener, A-312110, with recombinant sulphonylurea receptors and KATP channels: comparison with the cyanoguanidine P1075. Br J Pharmacol. 2004 Apr;141(7):1098-105. Epub 2004 Mar 15. - Pubmed Zhao JL, Yang YJ, You SJ, Jing ZC, Wu YJ, Cheng JL, Gao RL: Pretreatment with fosinopril or valsartan reduces myocardial no-reflow after acute myocardial infarction and reperfusion. Coron Artery Dis. 2006 Aug;17(5):463-9. - Pubmed Wang YH, Zheng HY, Qin NL, Yu SB, Liu SY: Involvement of ATP-sensitive potassium channels in proliferation and differentiation of rat preadipocytes. Sheng Li Xue Bao. 2007 Feb 25;59(1):8-12. - Pubmed
DTHybrid score	0.2072
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Pharmacological action	unknown
Actions	inhibitor
References	Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology. 2002 Nov;123(5):1649-58. - Pubmed Kemp DC, Brouwer KL: Viability assessment in sandwich-cultured rat hepatocytes after xenobiotic exposure. Toxicol In Vitro. 2004 Dec;18(6):869-77. - Pubmed Horikawa M, Kato Y, Tyson CA, Sugiyama Y: Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans. Drug Metab Pharmacokinet. 2003;18(1):16-22. - Pubmed
DTHybrid score	0.3453
ATP-binding cassette sub-family A member 1
Name	ATP-binding cassette sub-family A member 1
Gene Name	ABCA1
Pharmacological action	unknown
Actions	inhibitor
References	Reddy ST, Hama S, Ng C, Grijalva V, Navab M, Fogelman AM: ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells. Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1877-83. - Pubmed Muhl H, Hofler S, Pfeilschifter J: Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide. Eur J Pharmacol. 2003 Dec 15;482(1-3):325-8. - Pubmed Agassandian M, Mathur SN, Zhou J, Field FJ, Mallampalli RK: Oxysterols trigger ABCA1-mediated basolateral surfactant efflux. Am J Respir Cell Mol Biol. 2004 Aug;31(2):227-33. Epub 2004 Mar 23. - Pubmed Nieland TJ, Chroni A, Fitzgerald ML, Maliga Z, Zannis VI, Kirchhausen T, Krieger M: Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide. J Lipid Res. 2004 Jul;45(7):1256-65. Epub 2004 Apr 21. - Pubmed Alder-Baerens N, Muller P, Pohl A, Korte T, Hamon Y, Chimini G, Pomorski T, Herrmann A: Headgroup-specific exposure of phospholipids in ABCA1-expressing cells. J Biol Chem. 2005 Jul 15;280(28):26321-9. Epub 2005 May 19. - Pubmed
DTHybrid score	0.44
Cystic fibrosis transmembrane conductance regulator
Name	Cystic fibrosis transmembrane conductance regulator
Gene Name	CFTR
Pharmacological action	unknown
Actions	antagonist
References	Reddy MM, Quinton PM: Effect of anion transport blockers on CFTR in the human sweat duct. J Membr Biol. 2002 Sep 1;189(1):15-25. - Pubmed Jiang J, Song Y, Bai C, Koller BH, Matthay MA, Verkman AS: Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier. J Appl Physiol. 2003 Jan;94(1):343-52. Epub 2002 Aug 30. - Pubmed Zhou Z, Hu S, Hwang TC: Probing an open CFTR pore with organic anion blockers. J Gen Physiol. 2002 Nov;120(5):647-62. - Pubmed Larsen EH, Amstrup J, Willumsen NJ: Beta-adrenergic receptors couple to CFTR chloride channels of intercalated mitochondria-rich cells in the heterocellular toad skin epithelium. Biochim Biophys Acta. 2003 Dec 30;1618(2):140-52. - Pubmed Lee SY, Lee CO: Inhibition of Na+-K+ pump and L-type Ca2+ channel by glibenclamide in Guinea pig ventricular myocytes. J Pharmacol Exp Ther. 2005 Jan;312(1):61-8. Epub 2004 Sep 13. - Pubmed
DTHybrid score	0.4552
ATP-sensitive inward rectifier potassium channel 11
Name	ATP-sensitive inward rectifier potassium channel 11
Gene Name	KCNJ11
Pharmacological action	unknown
Actions	modulator
References	Hambrock A, Loffler-Walz C, Quast U: Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides. Br J Pharmacol. 2002 Aug;136(7):995-1004. - Pubmed Nielsen FE, Bodvarsdottir TB, Worsaae A, MacKay P, Stidsen CE, Boonen HC, Pridal L, Arkhammar PO, Wahl P, Ynddal L, Junager F, Dragsted N, Tagmose TM, Mogensen JP, Koch A, Treppendahl SP, Hansen JB: 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. J Med Chem. 2002 Sep 12;45(19):4171-87. - Pubmed Gojkovic-Bukarica L, Hambrock A, Loffler-Walz C, Quast U, Russ U: Mg2+ sensitizes KATP channels to inhibition by DIDS: dependence on the sulphonylurea receptor subunit. Br J Pharmacol. 2002 Oct;137(4):429-40. - Pubmed Ball AJ, McCluskey JT, Flatt PR, McClenaghan NH: Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not transcription of K(ATP) channel components. Pharmacol Res. 2004 Jul;50(1):41-6. - Pubmed Lim JG, Lee HY, Yun JE, Kim SP, Park JW, Suh SI, Jang BC, Cho CH, Bae JH, Kim SS, Han J, Park MJ, Song DK: Taurine block of cloned ATP-sensitive K+ channels with different sulfonylurea receptor subunits expressed in Xenopus laevis oocytes. Biochem Pharmacol. 2004 Sep 1;68(5):901-10. - Pubmed
DTHybrid score	0.3989

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7114
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8102
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5434

Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	inhibitor
References	Gedeon C, Behravan J, Koren G, Piquette-Miller M: Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102. Epub 2006 Feb 3. - Pubmed
DTHybrid score	0.275
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	inhibitor
References	Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology. 2002 Nov;123(5):1649-58. - Pubmed Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed Noe J, Hagenbuch B, Meier PJ, St-Pierre MV: Characterization of the mouse bile salt export pump overexpressed in the baculovirus system. Hepatology. 2001 May;33(5):1223-31. - Pubmed Funk C, Pantze M, Jehle L, Ponelle C, Scheuermann G, Lazendic M, Gasser R: Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate. Toxicology. 2001 Oct 5;167(1):83-98. - Pubmed Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ: Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology. 2000 Feb;118(2):422-30. - Pubmed
DTHybrid score	0.3453
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Golstein PE, Boom A, van Geffel J, Jacobs P, Masereel B, Beauwens R: P-glycoprotein inhibition by glibenclamide and related compounds. Pflugers Arch. 1999 Apr;437(5):652-60. - Pubmed
DTHybrid score	0.7506
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	inhibitor
References	Payen L, Delugin L, Courtois A, Trinquart Y, Guillouzo A, Fardel O: The sulphonylurea glibenclamide inhibits multidrug resistance protein (MRP1) activity in human lung cancer cells. Br J Pharmacol. 2001 Feb;132(3):778-84. - Pubmed Gedeon C, Behravan J, Koren G, Piquette-Miller M: Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102. Epub 2006 Feb 3. - Pubmed
DTHybrid score	0.4151
Oligopeptide transporter, small intestine isoform
Name	Oligopeptide transporter, small intestine isoform
Gene Name	SLC15A1
Actions	inhibitor
References	Sawada K, Terada T, Saito H, Hashimoto Y, Inui K: Effects of glibenclamide on glycylsarcosine transport by the rat peptide transporters PEPT1 and PEPT2. Br J Pharmacol. 1999 Nov;128(6):1159-64. - Pubmed
DTHybrid score	0.6497
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. - Pubmed
DTHybrid score	0.4526
Oligopeptide transporter, kidney isoform
Name	Oligopeptide transporter, kidney isoform
Gene Name	SLC15A2
Actions	inhibitor
References	Sawada K, Terada T, Saito H, Hashimoto Y, Inui K: Effects of glibenclamide on glycylsarcosine transport by the rat peptide transporters PEPT1 and PEPT2. Br J Pharmacol. 1999 Nov;128(6):1159-64. - Pubmed
DTHybrid score	0.6221
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Uwai Y, Saito H, Hashimoto Y, Inui K: Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1. Eur J Pharmacol. 2000 Jun 16;398(2):193-7. - Pubmed
DTHybrid score	0.5894
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	inhibitor
References	Gedeon C, Behravan J, Koren G, Piquette-Miller M: Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102. Epub 2006 Feb 3. - Pubmed Payen L, Delugin L, Courtois A, Trinquart Y, Guillouzo A, Fardel O: The sulphonylurea glibenclamide inhibits multidrug resistance protein (MRP1) activity in human lung cancer cells. Br J Pharmacol. 2001 Feb;132(3):778-84. - Pubmed
DTHybrid score	0.4603
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate,inhibitor
References	Gedeon C, Behravan J, Koren G, Piquette-Miller M: Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102. Epub 2006 Feb 3. - Pubmed Pollex EK, Anger G, Hutson J, Koren G, Piquette-Miller M: Breast cancer resistance protein (BCRP)-mediated glyburide transport: effect of the C421A/Q141K BCRP single-nucleotide polymorphism. Drug Metab Dispos. 2010 May;38(5):740-4. Epub 2010 Feb 16. - Pubmed
DTHybrid score	0.4498
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	inhibitor
References	Morita N, Kusuhara H, Sekine T, Endou H, Sugiyama Y: Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1179-84. - Pubmed
DTHybrid score	0.323
Solute carrier organic anion transporter family member 2B1
Name	Solute carrier organic anion transporter family member 2B1
Gene Name	SLCO2B1
Actions	substrate
References	Satoh H, Yamashita F, Tsujimoto M, Murakami H, Koyabu N, Ohtani H, Sawada Y: Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos. 2005 Apr;33(4):518-23. Epub 2005 Jan 7. - Pubmed
DTHybrid score	0.3735

Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions
References	Not Available
DTHybrid score	0.275
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions
References	Not Available
DTHybrid score	0.3453
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.7506
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions
References	Not Available
DTHybrid score	0.4151
Oligopeptide transporter, small intestine isoform
Name	Oligopeptide transporter, small intestine isoform
Gene Name	SLC15A1
Actions
References	Not Available
DTHybrid score	0.6497
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions
References	Not Available
DTHybrid score	0.4526
Oligopeptide transporter, kidney isoform
Name	Oligopeptide transporter, kidney isoform
Gene Name	SLC15A2
Actions
References	Not Available
DTHybrid score	0.6221
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions
References	Not Available
DTHybrid score	0.5894
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions
References	Not Available
DTHybrid score	0.4603
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions
References	Not Available
DTHybrid score	0.4498
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions
References	Not Available
DTHybrid score	0.323
Solute carrier organic anion transporter family member 2B1
Name	Solute carrier organic anion transporter family member 2B1
Gene Name	SLCO2B1
Actions
References	Not Available
DTHybrid score	0.3735

Id	Partner name	Gene Name	Score
4924	Cytochrome P450 2C8	CYP2C8	0.3692
4119	Cytochrome P450 2D6	CYP2D6	0.325
4118	Cytochrome P450 3A5	CYP3A5	0.304
4200	Cytochrome P450 1A2	CYP1A2	0.2946
6142	Solute carrier family 22 member 8	SLC22A8	0.2944
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.2472
6107	Cytochrome P450 3A7	CYP3A7	0.2148
20	Prostaglandin G/H synthase 1	PTGS1	0.2079
1024	Solute carrier family 22 member 11	SLC22A11	0.2045
244	Angiotensin-converting enzyme	ACE	0.2018
6030	Cytochrome P450 2B6	CYP2B6	0.1962
2164	Multidrug resistance-associated protein 4	ABCC4	0.1858
118	Organic cation/carnitine transporter 2	SLC22A5	0.1715
4604	Liver carboxylesterase 1	CES1	0.1708
6013	Cytochrome P450 2E1	CYP2E1	0.1646
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.1559
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.1539
6145	Solute carrier family 22 member 1	SLC22A1	0.1342
6141	Sodium/bile acid cotransporter	SLC10A1	0.1337
6024	Cytochrome P450 1A1	CYP1A1	0.1336
1181	Alpha-1-acid glycoprotein 1	ORM1	0.132
290	Prostaglandin G/H synthase 2	PTGS2	0.1249
633	Penicillin-binding proteins 1A/1B	pbpA	0.1239
5718	Cytochrome P450 2A6	CYP2A6	0.1141
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.1111
738	Monocarboxylate transporter 1	SLC16A1	0.1095
6144	Solute carrier family 22 member 2	SLC22A2	0.1035
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1008
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0967
6106	Cytochrome P450 2C18	CYP2C18	0.0934
6148	Multidrug resistance-associated protein 7	ABCC10	0.0875
1898	Cytochrome P450 1B1	CYP1B1	0.0872
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0847
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0845
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0763
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0751
6137	Multidrug resistance-associated protein 6	ABCC6	0.0741
817	DNA topoisomerase 2-alpha	TOP2A	0.0695
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0694
136	Estrogen receptor	ESR1	0.0692
6136	Multidrug resistance-associated protein 5	ABCC5	0.0689
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0676
6147	Solute carrier family 22 member 3	SLC22A3	0.0621
645	Penicillin-binding protein 1A	mrcA	0.0616
5805	Penicillin-binding protein 1A	ponA	0.0616
6185	Penicillin-binding protein 1A	mrcA	0.0616
6799	Penicillin-binding protein 1A	pbpA	0.0616
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0596
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0592
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0592
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0591
1	Peptidoglycan synthetase ftsI	ftsI	0.0578
4155	Peptidoglycan synthetase ftsI	ftsI	0.0578
3811	Cytochrome P450 19A1	CYP19A1	0.0575
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0567
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0564
731	HIV-1 protease	HIV-1 protease	0.0547
318	Alpha-2A adrenergic receptor	ADRA2A	0.0538
492	Histamine H1 receptor	HRH1	0.0524
833	Organic cation/carnitine transporter 1	SLC22A4	0.0501
340	Apoptotic protease-activating factor 1	APAF1	0.0489
543	Penicillin-binding protein 1B	mrcB	0.0483
6186	Penicillin-binding protein 1B	ponB	0.0483
6822	Penicillin-binding protein 1b	pbp1b	0.0483
6844	Penicillin-binding protein 1b	pbp1b	0.0483
3923	Cholinesterase	BCHE	0.0483
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.047
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0468
33	Cystine/glutamate transporter	SLC7A11	0.0467
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0464
824	Sodium-dependent serotonin transporter	SLC6A4	0.0462
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.046
556	Alpha-1A adrenergic receptor	ADRA1A	0.0459
825	Arsenical pump-driving ATPase	ASNA1	0.0457
3435	Arsenical pump-driving ATPase	arsA	0.0457
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0457
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0457
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0457
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0457
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0457
733	Activin receptor type 1B	ACVR1B	0.0457
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0457
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0457
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0457
154	AFG3-like protein 2	AFG3L2	0.0457
395	ALK tyrosine kinase receptor	Not Available	0.0457
183	Vascular endothelial growth factor A	VEGFA	0.0454
378	Alpha-2C adrenergic receptor	ADRA2C	0.0449
871	Glucocorticoid receptor	NR3C1	0.0441
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0439
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0434
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.043
468	Cytochrome P450 4A11	CYP4A11	0.0424
3917	Methylenetetrahydrofolate reductase	MTHFR	0.042
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0411
1757	Myeloperoxidase	MPO	0.041
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0399
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0389
297	Adenylate cyclase type 1	ADCY1	0.0389
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0389
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0388
295	Carbonic anhydrase 1	CA1	0.0386
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0384
6167	Organic solute transporter subunit beta	OSTB	0.0384
6166	Organic solute transporter subunit alpha	OSTA	0.0383
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0383
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0376
70	Type-1 angiotensin II receptor	AGTR1	0.0376
1385	Angiotensin-converting enzyme 2	ACE2	0.0376
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0373
24	Thymidylate synthase	TMP1	0.0372
359	Thymidylate synthase	TYMS	0.0372
2626	Thymidylate synthase	thyA	0.0372
2729	Thymidylate synthase	thyA	0.0372
5352	Thymidylate synthase	THYA	0.0372
849	Activated CDC42 kinase 1	TNK2	0.0369
292	Activin receptor type-1	ACVR1	0.0368
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0368
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0367
6085	Fatty acid-binding protein, intestinal	FABP2	0.0361
404	DNA gyrase subunit A	gyrA	0.036
6224	DNA gyrase subunit A	gyrA	0.036
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0357
484	Tyrosine-protein kinase ABL2	ABL2	0.0353
629	Alpha-2B adrenergic receptor	ADRA2B	0.0349
6031	Cytochrome P450 3A43	CYP3A43	0.0348
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0345
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0344
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0343
6149	Solute carrier family 22 member 10	SLC22A10	0.0343
831	D(2) dopamine receptor	DRD2	0.0341
891	Dihydropteroate synthase	folP	0.034
5359	Dihydropteroate synthase	folP	0.034
7175	Dihydropteroate synthase	sulI	0.034
357	Carbonic anhydrase 2	CA2	0.0339
161	Tubulin beta chain	TUBB	0.033
312	Tubulin beta chain	TUB2	0.033
558	Solute carrier family 12 member 1	SLC12A1	0.0325
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0319
904	Glutathione S-transferase P	GSTP1	0.0318
844	Epidermal growth factor receptor	EGFR	0.0317
632	Alpha-1B adrenergic receptor	ADRA1B	0.0316
273	Apoptosis regulator Bcl-2	BCL2	0.0311
260	Cytochrome P450 51	ERG11	0.0309
761	Cytochrome P450 51	ERG11	0.0309
3163	Cytochrome P450 51	cyp51	0.0309
3587	Gastrotropin	FABP6	0.0308
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0308
3947	Xanthine dehydrogenase/oxidase	XDH	0.0297
740	Argininosuccinate synthase	ASS1	0.0296
865	Argininosuccinate synthase	ASS1	0.0296
2680	Argininosuccinate synthase	argG	0.0296
3194	Argininosuccinate synthase	argG	0.0296
6021	Adenosine kinase	ADK	0.0295
146	Androgen receptor	AR	0.029
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0289
477	DNA topoisomerase 4 subunit A	parC	0.0289
886	DNA topoisomerase 4 subunit A	parC	0.0289
6226	DNA topoisomerase 4 subunit A	parC	0.0289
338	DNA polymerase	UL30	0.0284
379	DNA polymerase	UL54	0.0284
697	DNA polymerase	ORF28	0.0284
2482	DNA polymerase	43	0.0284
4104	DNA polymerase	BALF5	0.0284
756	Sex hormone-binding globulin	SHBG	0.0284
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0281
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0279
466	Solute carrier family 12 member 3	SLC12A3	0.0277
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0274
751	Potassium channel subfamily K member 6	KCNK6	0.0273
6067	Penicillin binding protein 2a	mecA	0.0271
661	ADP/ATP translocase 1	SLC25A4	0.0271
23	D(1A) dopamine receptor	DRD1	0.027
869	Estrogen receptor beta	ESR2	0.027
614	Progesterone receptor	PGR	0.0268
380	Cytochrome P450 17A1	CYP17A1	0.0268
29	Tubulin beta-1 chain	TUBB1	0.0263
275	Arachidonate 5-lipoxygenase	ALOX5	0.026
53	Solute carrier family 12 member 5	SLC12A5	0.0259
663	Solute carrier family 12 member 4	SLC12A4	0.0259
4120	NADPH--cytochrome P450 reductase	POR	0.0256
504	Mast/stem cell growth factor receptor	KIT	0.0255
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0255
373	Transthyretin	TTR	0.0253
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0252
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0251
172	Potassium channel subfamily K member 1	KCNK1	0.0248
3941	Amine oxidase [flavin-containing] A	MAOA	0.0247
3810	Catechol O-methyltransferase	COMT	0.0246
234	Plasminogen	PLG	0.0246
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0246
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0242
4773	Deoxycytidine kinase	DCK	0.0241
672	Prostaglandin F2-alpha receptor	PTGFR	0.024
1353	DNA topoisomerase 1	TOP1	0.024
3552	DNA topoisomerase 1	topA	0.024
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.024
310	Solute carrier family 12 member 2	SLC12A2	0.024
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.024
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0236
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0236
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0236
115	Penicillin-binding protein 2	mrdA	0.0235
6069	Penicillin-binding protein 2	mrdA	0.0235
6118	Penicillin-binding protein 2	penA	0.0235
6187	Penicillin-binding protein 2	pbpA	0.0235
6686	Penicillin-binding protein 2	pbp2	0.0235
6939	Penicillin-binding protein 2	mrdA	0.0235
7163	Penicillin-binding protein 2	pbpA	0.0235
847	Mu-type opioid receptor	OPRM1	0.0232
592	Carbonic anhydrase 4	CA4	0.0231
56	Delta-aminolevulinic acid dehydratase	ALAD	0.023
2356	Delta-aminolevulinic acid dehydratase	hemB	0.023
3613	Delta-aminolevulinic acid dehydratase	hemB	0.023
3674	Delta-aminolevulinic acid dehydratase	hemB	0.023
2539	Tubulin alpha-1 chain	TUBA4A	0.023
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0229
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0228
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0225
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0224
1650	Heme carrier protein 1	SLC46A1	0.0222
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0222
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0218
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0218
2808	Chloramphenicol acetyltransferase 3	cat3	0.0218
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0218
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0217
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0216
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0213
122	P2Y purinoceptor 12	P2RY12	0.0211
489	Monocarboxylate transporter 2	SLC16A7	0.021
908	Glutathione S-transferase theta-1	GSTT1	0.021
766	Beta-2 adrenergic receptor	ADRB2	0.0209
49	Endothelin B receptor	EDNRB	0.0209
6070	Nischarin	NISCH	0.0208
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0208
2021	Thrombomodulin	THBD	0.0208
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0206
467	Delta-type opioid receptor	OPRD1	0.0205
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0205
1792	Tissue-type plasminogen activator	PLAT	0.0205
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0204
683	Potassium transporter	GK0582	0.0203
4192	DNA topoisomerase 2-beta	TOP2B	0.0202
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0202
293	Gamma-glutamyl hydrolase	GGH	0.02
1852	Microtubule-associated protein 2	MAP2	0.02
696	Kappa-type opioid receptor	OPRK1	0.0199
140	30S ribosomal protein S9	rpsI	0.0198
6719	30S ribosomal protein S9	rpsI	0.0198
6725	30S ribosomal protein S9	rpsI	0.0198
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0198
2544	Bacterial leucyl aminopeptidase	Not Available	0.0198
737	Mineralocorticoid receptor	NR3C2	0.0197
578	Endothelin-1 receptor	EDNRA	0.0197
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0196
3639	Thymidine phosphorylase	deoA	0.0196
3936	Thymidine phosphorylase	TYMP	0.0196
6020	Aldehyde oxidase	AOX1	0.0194
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0192
713	Sodium-dependent dopamine transporter	SLC6A3	0.0191
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0189
5923	Microtubule-associated protein tau	MAPT	0.0189
5924	Microtubule-associated protein 4	MAP4	0.0189
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0188
5626	Nucleoside diphosphate kinase B	NME2	0.0186
117	Sterol O-acyltransferase 1	SOAT1	0.0185
22	30S ribosomal protein S4	rpsD	0.0185
6714	30S ribosomal protein S4	rpsD	0.0185
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0184
407	Vascular endothelial growth factor receptor 2	KDR	0.0183
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0182
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0182
3270	Elongation factor G	fusA	0.0181
193	Beta-1 adrenergic receptor	ADRB1	0.0181
723	Cytosolic phospholipase A2	PLA2G4A	0.018
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.018
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0179
4237	50S ribosomal protein L22	rplV	0.0176
159	Penicillin-binding protein 2B	penA	0.0175
6121	Penicillin-binding protein 2B	penA	0.0175
6043	Putative G-protein coupled receptor 44	GPR44	0.0173
789	Alpha-1D adrenergic receptor	ADRA1D	0.0172
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0171
4238	50S ribosomal protein L4	rplD	0.0171
5578	50S ribosomal protein L4	rplD	0.0171
6173	50S ribosomal protein L4	rplD	0.0171
6219	50S ribosomal protein L4	rplD	0.0171
4252	Penicillin-binding protein 5	dacA	0.0171
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0171
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
3760	Penicillin-binding protein 5 precursor	dacA	0.0169
527	Prostacyclin receptor	PTGIR	0.0168
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0168
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0168
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0167
6220	Aryl hydrocarbon receptor	AHR	0.0166
5294	Nucleoside diphosphate kinase A	NME1	0.0166
6182	Cytochrome P450 2J2	CYP2J2	0.0165
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0164
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0162
952	Dipeptidyl peptidase 4	DPP4	0.0161
26	Vascular endothelial growth factor receptor 3	FLT4	0.0161
465	Calmodulin	CALM1	0.016
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.016
5787	Angiopoietin-1 receptor	TEK	0.0158
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0157
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0157
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0155
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0155
2514	Phosphocarrier protein HPr	ptsH	0.0154
5689	Phosphocarrier protein HPr	ptsH	0.0154
3602	Anti-sigma F factor antagonist	spoIIAA	0.0154
32	Vascular endothelial growth factor receptor 1	FLT1	0.0154
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0154
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
5686	Potassium voltage-gated channel subfamily C member 4	KCNC4	0.0154
284	DNA-directed RNA polymerase beta chain	rpoB	0.0152
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0152
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0152
818	50S ribosomal protein L10	rplJ	0.0151
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0151
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.015
124	Histamine H2 receptor	HRH2	0.015
4122	Histone deacetylase 2	HDAC2	0.015
3060	Leukotriene A-4 hydrolase	LTA4H	0.0149
867	Penicillin-binding protein 3	pbpC	0.0148
6119	Penicillin-binding protein 3	pbp3	0.0148
7154	Penicillin-binding protein 3	pbp3	0.0148
7157	Penicillin-binding protein 3	LMHCC_2184	0.0148
7162	Penicillin-binding protein 3	pbpB	0.0148
7172	Penicillin-binding protein 3	pbp3	0.0148
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0145
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
65	Matrix metalloproteinase-9	Not Available	0.0144
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0143
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0142
1629	Transcription factor AP-1	JUN	0.014
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0139
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0138
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0138
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0137
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0136
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0136
3939	Amine oxidase [flavin-containing] B	MAOB	0.0136
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0135
6033	High affinity interleukin-8 receptor A	CXCR1	0.0135
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0134
1130	Lithostathine 1 alpha	REG1A	0.0134
3809	Estrogen-related receptor gamma	ESRRG	0.0134
4542	Glutaminase 1	glsA1	0.0134
4544	Glutaminase 1	glsA1	0.0134
6126	Carbonic anhydrase 7	CA7	0.0133
6146	High affinity copper uptake protein 1	SLC31A1	0.0133
702	UMP-CMP kinase	CMPK1	0.0132
461	Glycine receptor subunit alpha-3	GLRA3	0.0132
2530	Protein kinase C theta type	PRKCQ	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
6218	Pannexin-1	PANX1	0.0131
232	Corticosteroid-binding globulin	SERPINA6	0.0131
638	D(3) dopamine receptor	DRD3	0.013
4318	Siroheme synthase	cysG	0.013
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.013
3307	Acriflavine resistance protein B	acrB	0.013
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.013
2449	Tubulin alpha-3 chain	TUBA1A	0.013
1867	Major prion protein	PRNP	0.0129
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0128
896	Glutathione S-transferase Mu 1	GSTM1	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
2320	Thymidine kinase, cytosolic	TK1	0.0128
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0127
469	Annexin A1	ANXA1	0.0127
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0127
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0127
992	Protein tyrosine kinase 2 beta	PTK2B	0.0126
365	Dihydrofolate reductase	DHFR	0.0126
2381	Dihydrofolate reductase	DFR1	0.0126
2833	Dihydrofolate reductase	Not Available	0.0126
2931	Dihydrofolate reductase	folA	0.0126
3544	Dihydrofolate reductase	folA	0.0126
3682	Dihydrofolate reductase	folA	0.0126
6642	Dihydrofolate reductase	folA	0.0126
6756	Dihydrofolate reductase	dfrA	0.0126
509	Thymidine kinase	TK	0.0126
570	Thymidine kinase	TK	0.0126
2559	Thymidine kinase	TK	0.0126
3430	Thymidine kinase	tdk	0.0126
3518	Thymidine kinase	TK	0.0126
5301	Thymidine kinase	tdk	0.0126
5771	Thymidine kinase	ORF36	0.0126
7009	Thymidine kinase	ORF36	0.0126
165	FL cytokine receptor	FLT3	0.0126
1192	Sulfotransferase 1A1	SULT1A1	0.0125
3119	Fimbrial protein	pilE1	0.0125
5353	Glutamate decarboxylase alpha	gadA	0.0125
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0124
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0124
777	Tumor necrosis factor	TNF	0.0123
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
6014	Cytochrome P450 2A13	CYP2A13	0.0122
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0122
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0122
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0121
6163	Copper-transporting ATPase 2	ATP7B	0.0121
6165	Copper-transporting ATPase 1	ATP7A	0.0121
1760	Aminopeptidase N	ANPEP	0.012
6843	Aminopeptidase N	pepN	0.012
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.012
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0119
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0117
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0117
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0117
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0117
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0117
2207	Rhodopsin	RHO	0.0116
5818	Folate receptor alpha	FOLR1	0.0116
3453	Alkaline phosphatase	phoA	0.0116
6210	Tubulin delta chain	TUBD1	0.0114
6212	Tubulin gamma-1 chain	TUBG1	0.0114
6211	Tubulin epsilon chain	TUBE1	0.0114
1178	Adenosine A2a receptor	ADORA2A	0.0114
299	Folate receptor beta	FOLR2	0.0114
718	Folate receptor gamma	FOLR3	0.0114
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0114
3932	Glutathione S-transferase A2	GSTA2	0.0114
6042	Prostaglandin reductase 2	PTGR2	0.0114
594	Thyroxine-binding globulin	SERPINA7	0.0113
5150	Endo-1,4-beta-xylanase Y	xynY	0.0113
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0113
811	Translocator protein	TSPO	0.0113
6837	Serine/threonine-protein kinase 17B	STK17B	0.0112
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0112
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
4226	Uridine phosphorylase 2	UPP2	0.0111
1313	Lactoylglutathione lyase	GLO1	0.0111
6207	30S ribosomal protein S14	rpsN	0.0111
6209	30S ribosomal protein S19	rpsS	0.0111
6712	30S ribosomal protein S19	rpsS	0.0111
6726	30S ribosomal protein S19	rpsS	0.0111
500	Monocarboxylate transporter 4	SLC16A3	0.0111
2503	Phosphomannomutase/phosphoglucomutase	algC	0.011
6151	Monocarboxylate transporter 10	SLC16A10	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
2443	Azurin	azu	0.0108
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0107
16	Adenosine A1 receptor	ADORA1	0.0107
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0106
707	72 kDa type IV collagenase	MMP2	0.0106
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0106
7	Nitric oxide synthase, inducible	NOS2	0.0106
131	Synaptic vesicular amine transporter	SLC18A2	0.0105
758	Thyroid hormone receptor alpha	THRA	0.0105
2211	Fatty acid-binding protein, heart	FABP3	0.0105
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0104
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0104
2391	Ferrochelatase	hemH	0.0104
6502	Ferrochelatase	DKFZp686P18130	0.0104
1591	Ferrochelatase, mitochondrial	FECH	0.0104
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0104
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0103
2599	Tyrosine-protein kinase HCK	HCK	0.0103
482	Glycine receptor subunit alpha-1	GLRA1	0.0103
4225	Uridine phosphorylase 1	UPP1	0.0102
4217	Telomerase reverse transcriptase	TERT	0.0102
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0101
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0101
6102	Arylamine N-acetyltransferase 2	NAT2	0.0099
5650	NimA-related protein	DR_0842	0.0098
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0098
1050	Bile salt sulfotransferase	SULT2A1	0.0098
6501	Fatty acid-binding protein, liver	FABP1	0.0097
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0097
1010	Cytochrome P450 51A1	CYP51A1	0.0097
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0097
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0096
413	Amidophosphoribosyltransferase	PPAT	0.0096
2515	Amidophosphoribosyltransferase	purF	0.0096
3714	Amidophosphoribosyltransferase	purF	0.0096
432	D(4) dopamine receptor	DRD4	0.0096
936	Ephrin type-A receptor 2	EPHA2	0.0095
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0095
566	Serotransferrin	TF	0.0094
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0094
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0094
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0094
68	Cannabinoid receptor 1	CNR1	0.0094
346	Thyroid hormone receptor beta-1	THRB	0.0094
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0093
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0093
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0093
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0093
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0092
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0092
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0092
705	Glutamate receptor 1	GRIA1	0.0091
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
10	Glycogen phosphorylase, liver form	PYGL	0.0091
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.009
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.009
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.009
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.009
6493	Cytochrome c oxidase subunit 6C	COX6C	0.009
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.009
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.009
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.009
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.009
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.009
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.009
6559	Cytochrome c oxidase subunit 2	ctaC	0.009
6669	Cytochrome c oxidase subunit 2	ctaC	0.009
371	Cytochrome c oxidase subunit 1	MT-CO1	0.009
6558	Cytochrome c oxidase subunit 1	ctaD	0.009
6138	Multidrug resistance protein 3	ABCB4	0.009
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.009
3685	Catabolite gene activator	crp	0.0089
4655	Adenylate cyclase	cyaC	0.0089
4759	Adenylate cyclase	cyaB2	0.0089
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0089
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0089
1656	CYP2B protein	CYP2B	0.0088
823	Fibroblast growth factor receptor 2	FGFR2	0.0088
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0087
921	Glutamate receptor 2	GRIA2	0.0087
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0086
459	Retinoic acid receptor RXR-alpha	RXRA	0.0086
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0086
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0085
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0085
6168	Solute carrier family 22 member 16	SLC22A16	0.0085
1517	Beta-3 adrenergic receptor	ADRB3	0.0084
474	Acetylcholinesterase	ACHE	0.0084
207	Glutathione synthetase	GSS	0.0084
5269	Glutathione synthetase	gshB	0.0084
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0084
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0083
3856	Fibroblast growth factor receptor 3	FGFR3	0.0083
1152	Glycogen phosphorylase, muscle form	PYGM	0.0083
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0083
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0083
2540	Choloylglycine hydrolase	cbh	0.0083
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0082
6113	MecA PBP2' (penicillin binding protein 2')	mecA	0.0082
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0082
2016	Dipeptidase 1	DPEP1	0.0082
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0082
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
5646	Galactokinase	GALK1	0.0081
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0081
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0081
5302	TrwB	trwB	0.0081
5265	FtsH	ftsH	0.0081
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0081
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0081
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0081
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0079
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0079
84	Nuclear receptor 0B1	NR0B1	0.0079
716	5-hydroxytryptamine 7 receptor	HTR7	0.0078
860	Nicotinamide N-methyltransferase	NNMT	0.0078
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0078
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
699	Nicotinic acid receptor 1	GPR109A	0.0078
928	Nicotinic acid receptor 2	GPR109B	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
819	Penicillin-binding protein 4	dacB	0.0077
2249	Aspartate aminotransferase	aspC	0.0077
2671	Aspartate aminotransferase	aspC	0.0077
5490	Aspartate aminotransferase	Not Available	0.0077
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0077
1618	High affinity nerve growth factor receptor	NTRK1	0.0077
2298	Cytochrome P450-cam	camC	0.0076
4760	Mll3241 protein	mll3241	0.0076
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
5934	Cytochrome P450 26A1	CYP26A1	0.0074
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0073
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0073
5312	Kinesin-like protein KIF1A	KIF1A	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0072
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0072
163	D(1B) dopamine receptor	DRD5	0.0071
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0071
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0071
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0071
1714	Mitogen-activated protein kinase 3	MAPK3	0.0071
571	Melatonin receptor type 1A	MTNR1A	0.007
362	Melatonin receptor type 1B	MTNR1B	0.007
517	Alcohol dehydrogenase 1C	ADH1C	0.007
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.007
1630	Integrin beta-2	ITGB2	0.007
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.007
5300	Antigen peptide transporter 1	TAP1	0.007
130	Prostacyclin synthase	PTGIS	0.0069
427	Substance-P receptor	TACR1	0.0069
2853	14 kDa fatty acid-binding protein	Not Available	0.0068
2892	Acetylglutamate kinase	argB	0.0068
3550	Acetylglutamate kinase	argB	0.0068
2371	Pantothenate kinase	coaA	0.0068
1141	Sialidase-1	NEU1	0.0068
64	Neuraminidase	NA	0.0068
641	Neuraminidase	NA	0.0068
2676	Neuraminidase	NA	0.0068
3026	Neuraminidase	NA	0.0068
3519	Neuraminidase	NA	0.0068
6007	Neuraminidase	NA	0.0068
106	Cannabinoid receptor 2	CNR2	0.0068
2615	Chemotaxis protein cheA	cheA	0.0068
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0067
1881	Hexokinase-1	HK1	0.0067
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0067
4210	Toll-like receptor 4	TLR4	0.0067
36	Insulin receptor	INSR	0.0066
199	Monocarboxylate transporter 8	SLC16A2	0.0066
6824	Tyrosine-protein kinase Lyn	LYN	0.0065
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0065
6500	Phospholipase A2	PLA2G1B	0.0065
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0065
1291	cAMP response element-binding protein	CREB1	0.0064
1654	Interleukin-1 beta	IL1B	0.0064
2727	S-adenosylmethionine synthetase	metK	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0063
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0062
277	Purine nucleoside phosphorylase	PNP	0.0062
2870	Purine nucleoside phosphorylase	punA	0.0062
2945	Purine nucleoside phosphorylase	punA	0.0062
4659	Purine nucleoside phosphorylase	TM_1596	0.0062
4825	Purine nucleoside phosphorylase	TTHA1435	0.0062
408	Riboflavin kinase	RFK	0.0062
2216	Fibroblast growth factor receptor 4	FGFR4	0.0062
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0062
768	FK506-binding protein 1A	FKBP1A	0.0062
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0061
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0061
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0061
239	Coagulation factor X	F10	0.0061
291	Nitric-oxide synthase, endothelial	NOS3	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
4178	DNA repair protein RAD51 homolog 1	RAD51	0.006
5643	General secretion pathway protein E	epsE	0.006
3794	Osmolarity sensor protein envZ	envZ	0.006
5644	Sensor protein phoQ	phoQ	0.006
5641	Rod shape-determining protein MreB	TM_0588	0.006
5649	Potassium-transporting ATPase B chain	kdpB	0.0059
5642	Chaperone clpB	clpB	0.0059
5645	DNA topoisomerase 4 subunit B	parE	0.0059
6227	DNA topoisomerase 4 subunit B	parE	0.0059
2232	Interleukin-5	IL5	0.0059
76	Nitric-oxide synthase, brain	NOS1	0.0059
1593	Mucin-2	MUC2	0.0059
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
1123	Eosinophil cationic protein	RNASE3	0.0058
780	Retinoic acid receptor RXR-gamma	RXRG	0.0058
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0058
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0058
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0057
6044	Serum paraoxonase/lactonase 3	PON3	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
2852	DNA mismatch repair protein mutL	mutL	0.0057
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0056
1507	Cytochrome c	CYCS	0.0056
2251	Thymidylate kinase	tmk	0.0056
2254	Thymidylate kinase	DTYMK	0.0056
3522	Thymidylate kinase	tmk	0.0056
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0055
88	Retinoic acid receptor RXR-beta	RXRB	0.0053
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0053
1275	Estrogen sulfotransferase	SULT1E1	0.0053
572	Integrin alpha-L	ITGAL	0.0053
4751	Mitogen-activated protein kinase 12	MAPK12	0.0052
5482	Sialidase-2	NEU2	0.0052
2867	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	ispE	0.0052
2397	Dihydroxyacetone kinase	dhaK	0.0052
6433	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	PFKFB4	0.0052
494	Caspase-1	CASP1	0.0051
438	Taste receptor type 1 member 2	TAS1R2	0.0051
3822	Actin, alpha skeletal muscle	ACTA1	0.0051
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
1196	Complement decay-accelerating factor	CD55	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
6228	Nuclear receptor coactivator 1	NCOA1	0.005
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
976	Platelet glycoprotein IX	GP9	0.0049
6432	Transporter	snf	0.0049
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0049
3231	Death-associated protein kinase 1	DAPK1	0.0049
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0048
6131	Carbonic anhydrase 14	CA14	0.0048
2299	UDP-N-acetylmuramate--L-alanine ligase	murC	0.0048
856	Vitamin D3 receptor	VDR	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
6241	Nuclear receptor coactivator 2	NCOA2	0.0047
3014	Ribonuclease UK114	HRSP12	0.0046
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0046
5428	Replication protein	repA	0.0046
3617	Non-heme chloroperoxidase	cpo	0.0046
5426	Non-heme chloroperoxidase	cpo	0.0046
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0046
3018	HTH-type transcriptional regulator malT	malT	0.0046
887	DNA gyrase subunit B	gyrB	0.0046
4150	DNA gyrase subunit B	gyrB	0.0046
6225	DNA gyrase subunit B	gyrB	0.0046
814	Ryanodine receptor 1	RYR1	0.0045
3686	Acyl-CoA thioesterase I precursor	tesA	0.0045
54	Prothrombin	F2	0.0045
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0045
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0045
1039	Histone deacetylase 9	HDAC9	0.0045
6122	Carbonic anhydrase 3	CA3	0.0045
319	Opioid receptor, sigma 1	OPRS1	0.0045
2236	Casein kinase II subunit alpha	CSNK2A1	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
958	Insulin-like growth factor 1 receptor	IGF1R	0.0043
2077	Caspase-3	CASP3	0.0043
4103	Proteasome subunit beta type 2	PSMB2	0.0043
4102	Proteasome subunit beta type 5	PSMB5	0.0043
4101	Proteasome subunit beta type 1	PSMB1	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0042
6103	Arylamine N-acetyltransferase 1	NAT1	0.0042
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0042
4203	Histamine N-methyltransferase	HNMT	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1569	G1/S-specific cyclin-D1	CCND1	0.0041
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0041
1864	RET proto-oncogene	RET	0.0041
267	Plasminogen activator inhibitor 1	SERPINE1	0.0041
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0041
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0041
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
2417	Chloramphenicol acetyltransferase	cat	0.004
3278	Chloramphenicol acetyltransferase	cat	0.004
1992	Vitamin D-binding protein	GC	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
2810	Dr hemagglutinin structural subunit	draA	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
6174	50S ribosomal protein L32	rpmF	0.004
4161	Furin	FURIN	0.004
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.004
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.004
2958	Probable tautomerase ydcE	pptA	0.004
2573	Cocaine esterase	cocE	0.004
7263	Cocaine esterase	Not Available	0.004
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0039
1541	Metalloproteinase	mmp20	0.0039
94	5-hydroxytryptamine 4 receptor	HTR4	0.0039
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0039
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0039
3115	Ras-related protein Rab-9	RAB9A	0.0039
4041	Microsomal glutathione S-transferase 2	MGST2	0.0039
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
1198	Serum paraoxonase/arylesterase 1	PON1	0.0039
6223	Penicillin-binding protein 1C	pbpC	0.0039
268	Adenosine A2b receptor	ADORA2B	0.0038
6677	Myelin P2 protein	PMP2	0.0038
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0038
85	Growth hormone receptor	GHR	0.0038
3007	Carbonic anhydrase 12	CA12	0.0038
4205	Carbonic anhydrase 9	CA9	0.0038
6221	Steroid hormone receptor ERR1	ESRRA	0.0037
1525	Heparin-binding growth factor 2	FGF2	0.0037
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0037
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0036
634	Squalene monooxygenase	SQLE	0.0036
7196	Squalene monooxygenase	ERG1	0.0036
1025	Aquaporin-1	AQP1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
153	Dopamine beta-hydroxylase	DBH	0.0035
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0035
1836	Mitogen-activated protein kinase 10	MAPK10	0.0034
3957	Adenosine deaminase	ADA	0.0034
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0034
1928	Leukotriene C4 synthase	LTC4S	0.0034
4034	Glutaredoxin-1	GLRX	0.0034
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0034
4037	Hypothetical protein	GPX1	0.0034
4297	Hypothetical protein	SP_1951	0.0034
4521	Hypothetical protein	BC_2969	0.0034
4540	Hypothetical protein	TM_1070	0.0034
4555	Hypothetical protein	MT1739	0.0034
4569	Hypothetical protein	mshD	0.0034
4578	Hypothetical protein	PA3270	0.0034
4747	Hypothetical protein	PA3967	0.0034
5177	Hypothetical protein	TM_0096	0.0034
5194	Hypothetical protein	PA1204	0.0034
5240	Hypothetical protein	Rv2991	0.0034
5370	Hypothetical protein	TM_1158	0.0034
5710	Hypothetical protein	Tb927.5.1360	0.0034
907	Glutathione peroxidase 2	GPX2	0.0034
4029	Microsomal glutathione S-transferase 3	MGST3	0.0034
4032	Microsomal glutathione S-transferase 1	MGST1	0.0034
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0034
910	Epididymal secretory glutathione peroxidase	GPX5	0.0034
4040	Glutathione peroxidase 7	GPX7	0.0034
4036	Glutathione peroxidase 6	GPX6	0.0034
903	Glutathione S-transferase A5	GSTA5	0.0034
906	Glutathione peroxidase 1	GPX1	0.0034
900	Glutathione S-transferase A4	GSTA4	0.0034
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0034
911	Glutathione peroxidase 3	GPX3	0.0034
4035	Glutathione S-transferase Mu 5	GSTM5	0.0034
4033	S-formylglutathione hydrolase	ESD	0.0034
4038	Glutathione peroxidase 4	GPX4	0.0034
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0034
4042	Glutathione transferase omega-2	GSTO2	0.0034
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0034
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0034
5798	Mitogen-activated protein kinase 11	MAPK11	0.0034
518	Peroxidase/catalase T	katG	0.0033
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
1483	Membrane copper amine oxidase	AOC3	0.0033
332	Beta-lactamase	blaZ	0.0033
2478	Beta-lactamase	ampC	0.0033
2613	Beta-lactamase	ampC	0.0033
2635	Beta-lactamase	ampC	0.0033
2700	Beta-lactamase	penP	0.0033
5445	Beta-lactamase	blaB	0.0033
6019	Beta-lactamase	SHV-7	0.0033
6701	Beta-lactamase	cphA	0.0033
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0033
822	Aldose reductase	AKR1B1	0.0032
581	Cytochrome P450 2R1	CYP2R1	0.0032
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0032
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0031
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0031
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0031
4031	Glutathione S-transferase A1	GSTA1	0.0031
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
898	Glutathione S-transferase A3	GSTA3	0.0031
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0031
897	Glutathione S-transferase kappa 1	GSTK1	0.0031
5287	Signaling protein	Not Available	0.003
5288	Shikimate kinase	aroK	0.003
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.003
5304	UPF0166 protein TM_0021	TM_0021	0.003
3199	Phosphopantetheine adenylyltransferase	coaD	0.003
3543	Phosphopantetheine adenylyltransferase	coaD	0.003
3567	Phosphopantetheine adenylyltransferase	coaD	0.003
5289	Phosphopantetheine adenylyltransferase	coaD	0.003
4346	Polynucleotide kinase	pseT	0.003
5293	Shikimate kinase 2	aroL	0.003
5283	D-alanine--D-alanine ligase B	ddlB	0.003
5281	Plasmid segregation protein parM	parM	0.003
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.003
5292	Putative partitioning protein	TT_C1605	0.003
5276	Chromosomal replication initiator protein dnaA	dnaA	0.003
5266	Activator of	hgdC	0.003
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.003
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.003
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.003
2874	Nitrogenase iron protein 1	nifH1	0.003
5299	D-alanine--D-alanine ligase	ddl	0.003
6598	D-alanine--D-alanine ligase	ddl	0.003
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.003
1549	Heat shock 70 kDa protein 1	HSPA1A	0.003
5308	Preprotein translocase secA 1 subunit	secA1	0.003
5259	Transcriptional regulator	ntrC1	0.003
6699	Transcriptional regulator	Cgl2612	0.003
5284	Large T antigen	Not Available	0.003
5291	Glycogen synthase 1	glgA1	0.003
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.003
5264	DNA replication protein	REP	0.003
5277	Preprotein translocase subunit secA	secA	0.003
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.003
5285	Kinesin heavy chain	KIF5B	0.003
5315	Chaperone protein htpG	htpG	0.003
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.003
5261	Phosphoribosylformylglycinamidine synthase	purL	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
909	Maleylacetoacetate isomerase	GSTZ1	0.003
2693	Heat-labile enterotoxin B chain	eltB	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.003
905	Glutathione transferase omega-1	GSTO1	0.003
899	Glutathione S-transferase Mu 3	GSTM3	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0029
654	Flavin reductase	BLVRB	0.0029
6645	D-amino-acid oxidase	DAO	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
162	Retinoic acid receptor gamma-1	RARG	0.0029
563	Thyroid peroxidase	TPO	0.0028
2697	Uridine-cytidine kinase 2	UCK2	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
2165	Glutathione S-transferase Mu 2	GSTM2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
1405	Thiopurine S-methyltransferase	TPMT	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
605	Fumarate reductase flavoprotein subunit	frdA	0.0027
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0027
3673	Fumarate reductase flavoprotein subunit	fccA	0.0027
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0027
6549	Fumarate reductase flavoprotein subunit	frdA	0.0027
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0026
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
901	Glutathione S-transferase Mu 4	GSTM4	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0025
229	Retinoic acid receptor beta	RARB	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0025
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0025
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0025
2091	Endoplasmin	HSP90B1	0.0025
3470	Hypothetical protein MG245 homolog	MPN_348	0.0025
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0025
3426	Glutamine synthetase	glnA	0.0025
3987	Glutamine synthetase	GLUL	0.0025
3175	Glutamate--cysteine ligase	gshA	0.0025
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.0025
5189	Trimethylamine dehydrogenase	tmd	0.0025
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0025
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0025
4106	Guanylate kinase	GUK1	0.0025
4516	Guanylate kinase	gmk	0.0025
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0024
2270	Dephospho-CoA kinase	coaE	0.0024
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
4837	Cag-alfa	cag-alfa	0.0024
4774	NTPase P4	Not Available	0.0024
4838	PMS1 protein homolog 2	PMS2	0.0024
2284	Adenylate kinase	adk	0.0024
2296	Adenylate kinase	adk	0.0024
2311	Adenylate kinase	adk	0.0024
2312	Adenylate kinase	Not Available	0.0024
4839	DNA polymerase III subunit tau	dnaX	0.0024
1648	Elastin	ELN	0.0024
730	Retinoic acid receptor alpha	RARA	0.0024
4311	tRNA	TRDMT1	0.0024
4325	tRNA	trmD	0.0024
4328	tRNA	trmD	0.0024
3616	Fatty acid-binding protein, epidermal	FABP5	0.0024
5431	Lipid binding protein	Not Available	0.0024
5433	UPF0230 protein TM_1468	TM_1468	0.0024
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
164	Histamine H4 receptor	HRH4	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6171	Solute carrier family 28 member 3	SLC28A3	0.0024
6459	Glycodelin	PAEP	0.0024
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0024
3937	Fatty-acid amide hydrolase	FAAH	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3808	Dihydropteroate synthase 2	folP2	0.0023
3601	Dihydropteroate synthase 1	folP1	0.0023
3807	Dihydropteroate synthase 1	folP1	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
2683	Mono-ADP-ribosyltransferase C3	C3	0.0023
174	Sigma 1-type opioid receptor	SIGMAR1	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
5271	Focal adhesion kinase 1	PTK2	0.0022
714	Glutathione reductase, mitochondrial	GSR	0.0022
2390	Nonsecretory ribonuclease	RNASE2	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
2922	Glycerol kinase	glpK	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
2282	Protein recA	recA	0.0021
2315	Protein recA	recA	0.0021
2332	Protein recA	recA	0.0021
5263	Protein recA	recA	0.0021
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0021
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3669	Ribokinase	rbsK	0.002
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.002
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
760	Fibroblast growth factor 1	FGF1	0.002
283	SEC14-like protein 2	SEC14L2	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6755	Poliovirus receptor	PVR	0.002
788	Creatine kinase M-type	CKM	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
5682	Ribonuclease pancreatic	RNASE1	0.002
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.002
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0019
444	Alcohol dehydrogenase 1B	ADH1B	0.0019
2334	Dethiobiotin synthetase	bioD	0.0019
6555	Dethiobiotin synthetase	bioD	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0018
1253	Interferon gamma	IFNG	0.0018
2112	Toll-like receptor 9	TLR9	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0018
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0018
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
48	Pyridoxal kinase	PDXK	0.0018
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0018
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0018
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0018
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0018
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0018
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0018
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0017
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0017
251	Alcohol dehydrogenase 1A	ADH1A	0.0017
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
6395	Myosin-14	MYH14	0.0017
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0017
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
3830	Calreticulin	CALR	0.0017
4992	Cytochrome c peroxidase	Not Available	0.0017
1422	Serine/threonine-protein kinase 6	AURKA	0.0016
820	Glycine receptor subunit alpha-2	GLRA2	0.0016
3379	Kinesin-like protein KIF11	KIF11	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0016
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0016
1268	Neuropeptide S receptor	NPSR1	0.0016
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0016
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0016
2408	Tyrosine-protein kinase SYK	SYK	0.0016
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.0016
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0016
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0016
173	Toll-like receptor 7	TLR7	0.0016
2297	Genome polyprotein	Not Available	0.0016
2322	Genome polyprotein	Not Available	0.0016
2694	Genome polyprotein	Not Available	0.0016
2719	Genome polyprotein	Not Available	0.0016
2860	Genome polyprotein	Not Available	0.0016
2928	Genome polyprotein	Not Available	0.0016
3160	Genome polyprotein	Not Available	0.0016
3260	Genome polyprotein	Not Available	0.0016
4783	Genome polyprotein	Not Available	0.0016
5726	Genome polyprotein	Not Available	0.0016
5779	Genome polyprotein	Not Available	0.0016
5867	Genome polyprotein	Not Available	0.0016
6253	Genome polyprotein	Not Available	0.0016
6301	Genome polyprotein	Not Available	0.0016
6380	Genome polyprotein	Not Available	0.0016
6381	Genome polyprotein	Not Available	0.0016
6437	Genome polyprotein	Not Available	0.0016
6520	Genome polyprotein	Not Available	0.0016
6521	Genome polyprotein	Not Available	0.0016
6652	Genome polyprotein	Not Available	0.0016
6734	Genome polyprotein	Not Available	0.0016
6735	Genome polyprotein	Not Available	0.0016
6736	Genome polyprotein	Not Available	0.0016
6737	Genome polyprotein	Not Available	0.0016
6738	Genome polyprotein	Not Available	0.0016
6739	Genome polyprotein	Not Available	0.0016
6744	Genome polyprotein	Not Available	0.0016
6748	Genome polyprotein	Not Available	0.0016
6894	Genome polyprotein	Not Available	0.0016
6898	Genome polyprotein	Not Available	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
6048	Troponin C, skeletal muscle	TNNC2	0.0015
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0015
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0015
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
6073	Potassium channel subfamily K member 9	KCNK9	0.0015
6072	Potassium channel subfamily K member 3	KCNK3	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
3913	Glutamic acid decarboxylase	GAD65	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0013
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3221	Cytochrome c4	cc4	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
5590	N utilization substance protein B homolog	nusB	0.0012
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0012
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0012
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0012
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0012
2838	Ribose-5-phosphate isomerase A	rpiA	0.0012
2952	Ribose-5-phosphate isomerase A	rpiA	0.0012
5595	Ribose-5-phosphate isomerase A	rpiA	0.0012
4695	UPF0124 protein yfiH	yfiH	0.0012
5060	Intron-associated endonuclease 1	ITEVIR	0.0012
5593	Transferase	Not Available	0.0012
5588	Cell division protein FtsY	TM_0570	0.0012
5591	Complement component C8 gamma chain	C8G	0.0012
5587	Iron(III)-binding periplasmic protein	fbpA	0.0012
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0012
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0012
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0012
5581	Beta-fructosidase	bfrA	0.0012
5600	Pyruvate decarboxylase	pdc	0.0012
4375	Glutamine synthetase 1	glnA1	0.0012
5575	Short tail fiber protein	12	0.0012
5580	Hexon protein	PII	0.0012
5574	Invasin	YPTB1668	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
6859	Protein S100-A4	S100A4	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0011
3132	Tryptophan synthase alpha chain	trpA	0.0011
6568	Tryptophan synthase alpha chain	trpA	0.0011
5006	RNASE4 protein	RNASE4	0.0011
2555	Pol polyprotein	pol	0.0011
3242	Pol polyprotein	gag-pol	0.0011
3471	Pol polyprotein	gag-pro-pol	0.0011
5256	Pol polyprotein	pol	0.0011
6469	Pol polyprotein	gag-pol	0.0011
6565	Pol polyprotein	Not Available	0.0011
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0011
5328	Prostaglandin F synthase	Tb11.02.2310	0.0011
4533	Glyoxalase family protein	BC_1747	0.0011
3729	Citrate synthase	gltA	0.0011
4575	Citrate synthase	cit	0.0011
4580	Citrate synthase	gltA	0.0011
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
997	Protein kinase C beta type	PRKCB	0.001
4948	Cytochrome c-553	Not Available	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
2603	Beta-lactamase II	blm	0.001
2521	Cell division protein ftsZ	ftsZ	0.001
3301	Cell division protein ftsZ	ftsZ	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2149	Angiogenin	ANG	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
3583	6-phosphogluconolactonase	pgl	0.001
857	Malate dehydrogenase, mitochondrial	MDH2	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0009
2942	Sialidase	nanH	0.0009
3546	Sialidase	nedA	0.0009
3486	Fumarate hydratase class II	fumC	0.0009
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0009
719	Retinoic acid receptor responder protein 1	RARRES1	0.0009
2286	Isocitrate dehydrogenase [NADP]	icd	0.0009
2302	Isocitrate dehydrogenase [NADP]	icd	0.0009
2771	Isocitrate dehydrogenase [NADP]	icd	0.0009
770	Retinoic acid-induced protein 3	GPRC5A	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
2452	Tryptophanyl-tRNA synthetase	trpS	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
411	Glycine N-methyltransferase	GNMT	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
5579	Carboxypeptidase B	CPB1	0.0008
569	Retinal dehydrogenase 2	ALDH1A2	0.0008
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
3384	Macrophage migration inhibitory factor	MIF	0.0008
128	Adenine phosphoribosyltransferase	APRT	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
611	Retinal dehydrogenase 1	ALDH1A1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4943	Cytochrome c6	petJ	0.0006
4916	Cyanoglobin	glbN	0.0006
5000	HemO	hemO	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
4984	Neuroglobin	NGB	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4910	Cytoglobin	CYGB	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4909	CooA protein	cooA	0.0006
4961	Hemophore HasA	hasA	0.0006
644	Heme oxygenase 2	HMOX2	0.0006
4982	Heme oxygenase 2	pbsA2	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4972	P450cin	cinA	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4952	Catalase/peroxidase	katA	0.0006
3093	Catalase HPII	katE	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
5961	Insulin	INS	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4920	Peroxidase/catalase	katG	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6524	Protein tonB	tonB	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
2802	Endoglucanase G	celCCG	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
358	Cystathionine beta-synthase	CBS	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01016 - Glyburide

Targets

Enzymes

Transporters

Carriers

Predictions