DT-Web: DB00978

Identification

Name

Lomefloxacin

Accession Number

DB00978 (APRD01076)

Type

small molecule

Description

Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

351.3479

Groups

approved

Monoisotopic Weight

351.139447899

Pharmacology

Indication

For the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by: S.pneumoniae, H.influenzae, S.aureus, P.aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E.coli, and K.pneumoniae.

Mechanism of action

Lomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.

Absorption

Rapid and nearly complete with approximately 95% to 98% of a single oral dose being absorbed.

Protein binding

10%

Biotransformation

Minimally metabolized although 5 metabolites have been identified in human urine. 65% appears as the parent drug in urine and 9% as the glucuronide metabolite.

Route of elimination

The urinary excretion of lomefloxacin was virtually complete within 72 hours after cessation of dosing, with approximately 65% of the dose being recovered as parent drug and 9% as its glucuronide metabolite.

Toxicity

Adverse reactions include peripheral neuropathy, nervousness, agitation, anxiety, and phototoxic events (rash, itching, burning) due to sunlight exposure.

Affected organisms

Enteric bacteria and other eubacteria

Interactions

Drug Interactions

Drug	Mechanism of interaction
Calcium	Formation of non-absorbable complexes
Calcium Acetate	Calcium salts such as calcium acetate may decrease the absorption of quinolone antibiotics such as lomefloxacin. Of concern only with oral administration of both agents. Interactions can be minimized by administering oral quinolone at least 2 hours before, or 6 hours after, the dose of an oral calcium supplement. Monitor for decreased therapeutic effects of oral quinolones if administered with oral calcium supplements.
Iron Dextran	Formation of non-absorbable complexes
Magnesium	Formation of non-absorbable complexes

Food Interactions

Not Available

DNA topoisomerase 4 subunit A
Name	DNA topoisomerase 4 subunit A
Gene Name	parC
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Didier ES, Bowers L, Stovall ME, Kuebler D, Mittleider D, Brindley PJ, Didier PJ: Antimicrosporidial activity of (fluoro)quinolones in vitro and in vivo. Folia Parasitol (Praha). 2005 May;52(1-2):173-81. - Pubmed
DTHybrid score	0.928
DNA gyrase subunit A
Name	DNA gyrase subunit A
Gene Name	gyrA
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Takenouchi T, Ishii C, Sugawara M, Tokue Y, Ohya S: Incidence of various gyrA mutants in 451 Staphylococcus aureus strains isolated in Japan and their susceptibilities to 10 fluoroquinolones. Antimicrob Agents Chemother. 1995 Jul;39(7):1414-8. - Pubmed Drusano GL, Johnson DE, Rosen M, Standiford HC: Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis. Antimicrob Agents Chemother. 1993 Mar;37(3):483-90. - Pubmed Gushchin AE, Ladygina VG, Govorun VM: [Role of mutations in parC and gyrA in forming resistance of Mycoplasma hominis to fluoroquinolones] Mol Gen Mikrobiol Virusol. 1999;(4):19-24. - Pubmed
DTHybrid score	0.9626
DNA topoisomerase 2-alpha
Name	DNA topoisomerase 2-alpha
Gene Name	TOP2A
Pharmacological action	unknown
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.74

Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4084

Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions	inhibitor
References	Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score	0.2946
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	inhibitor
References	Sasabe H, Tsuji A, Sugiyama Y: Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats. J Pharmacol Exp Ther. 1998 Mar;284(3):1033-9. - Pubmed
DTHybrid score	0.2471

Id	Partner name	Gene Name	Score
6224	DNA gyrase subunit A	gyrA	0.9626
886	DNA topoisomerase 4 subunit A	parC	0.928
6226	DNA topoisomerase 4 subunit A	parC	0.928
4512	Cytochrome P450 3A4	CYP3A4	0.1617
1588	Multidrug resistance protein 1	ABCB1	0.1583
1729	Solute carrier family 22 member 6	SLC22A6	0.1204
862	Multidrug resistance-associated protein 1	ABCC1	0.1049
4119	Cytochrome P450 2D6	CYP2D6	0.1016
833	Organic cation/carnitine transporter 1	SLC22A4	0.0905
4757	Cytochrome P450 2C9	CYP2C9	0.0878
4118	Cytochrome P450 3A5	CYP3A5	0.0857
6144	Solute carrier family 22 member 2	SLC22A2	0.074
6016	Cytochrome P450 2C19	CYP2C19	0.0733
6107	Cytochrome P450 3A7	CYP3A7	0.0682
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0643
6024	Cytochrome P450 1A1	CYP1A1	0.0637
4924	Cytochrome P450 2C8	CYP2C8	0.0529
4192	DNA topoisomerase 2-beta	TOP2B	0.0478
6145	Solute carrier family 22 member 1	SLC22A1	0.0477
6013	Cytochrome P450 2E1	CYP2E1	0.0477
6030	Cytochrome P450 2B6	CYP2B6	0.0466
5718	Cytochrome P450 2A6	CYP2A6	0.0419
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0404
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0383
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0371
6142	Solute carrier family 22 member 8	SLC22A8	0.0338
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0333
6137	Multidrug resistance-associated protein 6	ABCC6	0.0328
776	Bile salt export pump	ABCB11	0.0317
4180	DNA-(apurinic or apyrimidinic site) lyase	APEX1	0.0305
6147	Solute carrier family 22 member 3	SLC22A3	0.0296
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0294
587	Serum albumin	ALB	0.0291
1898	Cytochrome P450 1B1	CYP1B1	0.0272
36	Insulin receptor	INSR	0.0258
2164	Multidrug resistance-associated protein 4	ABCC4	0.025
20	Prostaglandin G/H synthase 1	PTGS1	0.0226
6148	Multidrug resistance-associated protein 7	ABCC10	0.0224
1353	DNA topoisomerase 1	TOP1	0.0216
3552	DNA topoisomerase 1	topA	0.0216
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0214
1024	Solute carrier family 22 member 11	SLC22A11	0.0201
492	Histamine H1 receptor	HRH1	0.0196
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0193
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0192
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0189
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0178
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0174
318	Alpha-2A adrenergic receptor	ADRA2A	0.0174
70	Type-1 angiotensin II receptor	AGTR1	0.0173
136	Estrogen receptor	ESR1	0.0168
159	Penicillin-binding protein 2B	penA	0.0165
6121	Penicillin-binding protein 2B	penA	0.0165
6143	Solute carrier family 22 member 7	SLC22A7	0.0161
6106	Cytochrome P450 2C18	CYP2C18	0.0158
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
161	Tubulin beta chain	TUBB	0.0152
312	Tubulin beta chain	TUB2	0.0152
738	Monocarboxylate transporter 1	SLC16A1	0.0148
2539	Tubulin alpha-1 chain	TUBA4A	0.0145
290	Prostaglandin G/H synthase 2	PTGS2	0.0144
3941	Amine oxidase [flavin-containing] A	MAOA	0.014
3947	Xanthine dehydrogenase/oxidase	XDH	0.0136
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0136
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.013
1757	Myeloperoxidase	MPO	0.0129
629	Alpha-2B adrenergic receptor	ADRA2B	0.0127
6141	Sodium/bile acid cotransporter	SLC10A1	0.0125
556	Alpha-1A adrenergic receptor	ADRA1A	0.0121
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.012
3811	Cytochrome P450 19A1	CYP19A1	0.0116
824	Sodium-dependent serotonin transporter	SLC6A4	0.0116
723	Cytosolic phospholipase A2	PLA2G4A	0.0114
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0114
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0114
831	D(2) dopamine receptor	DRD2	0.0111
713	Sodium-dependent dopamine transporter	SLC6A3	0.011
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0109
2443	Azurin	azu	0.0108
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0105
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0105
3939	Amine oxidase [flavin-containing] B	MAOB	0.0104
633	Penicillin-binding proteins 1A/1B	pbpA	0.0104
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0104
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0102
908	Glutathione S-transferase theta-1	GSTT1	0.0102
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0101
23	D(1A) dopamine receptor	DRD1	0.01
193	Beta-1 adrenergic receptor	ADRB1	0.0099
115	Penicillin-binding protein 2	mrdA	0.0099
6069	Penicillin-binding protein 2	mrdA	0.0099
6118	Penicillin-binding protein 2	penA	0.0099
6187	Penicillin-binding protein 2	pbpA	0.0099
6686	Penicillin-binding protein 2	pbp2	0.0099
6939	Penicillin-binding protein 2	mrdA	0.0099
7163	Penicillin-binding protein 2	pbpA	0.0099
378	Alpha-2C adrenergic receptor	ADRA2C	0.0099
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
992	Protein tyrosine kinase 2 beta	PTK2B	0.0093
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0092
3923	Cholinesterase	BCHE	0.0091
632	Alpha-1B adrenergic receptor	ADRA1B	0.009
131	Synaptic vesicular amine transporter	SLC18A2	0.009
885	5-hydroxytryptamine 1B receptor	HTR1B	0.009
6010	Thiamine transporter 1	SLC19A2	0.0089
904	Glutathione S-transferase P	GSTP1	0.0086
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0084
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0083
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0083
1	Peptidoglycan synthetase ftsI	ftsI	0.0083
4155	Peptidoglycan synthetase ftsI	ftsI	0.0083
766	Beta-2 adrenergic receptor	ADRB2	0.0082
789	Alpha-1D adrenergic receptor	ADRA1D	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
175	Thiamin pyrophosphokinase 1	TPK1	0.008
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.008
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.008
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0079
474	Acetylcholinesterase	ACHE	0.0078
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0078
624	Guanidinoacetate N-methyltransferase	GAMT	0.0078
4120	NADPH--cytochrome P450 reductase	POR	0.0078
275	Arachidonate 5-lipoxygenase	ALOX5	0.0077
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0077
867	Penicillin-binding protein 3	pbpC	0.0077
6119	Penicillin-binding protein 3	pbp3	0.0077
7154	Penicillin-binding protein 3	pbp3	0.0077
7157	Penicillin-binding protein 3	LMHCC_2184	0.0077
7162	Penicillin-binding protein 3	pbpB	0.0077
7172	Penicillin-binding protein 3	pbp3	0.0077
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0077
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0074
1636	Trace amine-associated receptor 1	TAAR1	0.0073
645	Penicillin-binding protein 1A	mrcA	0.0073
5805	Penicillin-binding protein 1A	ponA	0.0073
6185	Penicillin-binding protein 1A	mrcA	0.0073
6799	Penicillin-binding protein 1A	pbpA	0.0073
737	Mineralocorticoid receptor	NR3C2	0.0072
777	Tumor necrosis factor	TNF	0.0072
6136	Multidrug resistance-associated protein 5	ABCC5	0.0072
185	Vasopressin V1a receptor	AVPR1A	0.0071
2417	Chloramphenicol acetyltransferase	cat	0.0071
3278	Chloramphenicol acetyltransferase	cat	0.0071
4604	Liver carboxylesterase 1	CES1	0.007
322	Vasopressin V2 receptor	AVPR2	0.007
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0069
869	Estrogen receptor beta	ESR2	0.0069
6168	Solute carrier family 22 member 16	SLC22A16	0.0067
614	Progesterone receptor	PGR	0.0067
16	Adenosine A1 receptor	ADORA1	0.0066
468	Cytochrome P450 4A11	CYP4A11	0.0065
638	D(3) dopamine receptor	DRD3	0.0065
380	Cytochrome P450 17A1	CYP17A1	0.0064
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0064
192	Creatine kinase, ubiquitous mitochondrial	CKMT1A	0.0063
456	Creatine kinase, sarcomeric mitochondrial	CKMT2	0.0063
92	Creatine kinase B-type	CKB	0.0063
414	Sodium- and chloride-dependent creatine transporter 1	SLC6A8	0.0063
273	Apoptosis regulator Bcl-2	BCL2	0.0063
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0063
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0062
3270	Elongation factor G	fusA	0.0062
731	HIV-1 protease	HIV-1 protease	0.0062
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0062
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0062
5626	Nucleoside diphosphate kinase B	NME2	0.0061
2808	Chloramphenicol acetyltransferase 3	cat3	0.0061
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.006
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.006
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.006
341	5-hydroxytryptamine 3 receptor	HTR3A	0.006
332	Beta-lactamase	blaZ	0.0059
2478	Beta-lactamase	ampC	0.0059
2613	Beta-lactamase	ampC	0.0059
2635	Beta-lactamase	ampC	0.0059
2700	Beta-lactamase	penP	0.0059
5445	Beta-lactamase	blaB	0.0059
6019	Beta-lactamase	SHV-7	0.0059
6701	Beta-lactamase	cphA	0.0059
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0059
24	Thymidylate synthase	TMP1	0.0059
359	Thymidylate synthase	TYMS	0.0059
2626	Thymidylate synthase	thyA	0.0059
2729	Thymidylate synthase	thyA	0.0059
5352	Thymidylate synthase	THYA	0.0059
6067	Penicillin binding protein 2a	mecA	0.0058
788	Creatine kinase M-type	CKM	0.0057
6220	Aryl hydrocarbon receptor	AHR	0.0056
6146	High affinity copper uptake protein 1	SLC31A1	0.0056
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0056
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0054
117	Sterol O-acyltransferase 1	SOAT1	0.0054
373	Transthyretin	TTR	0.0054
465	Calmodulin	CALM1	0.0054
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0053
124	Histamine H2 receptor	HRH2	0.0053
1178	Adenosine A2a receptor	ADORA2A	0.0053
432	D(4) dopamine receptor	DRD4	0.0053
1629	Transcription factor AP-1	JUN	0.0053
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0052
571	Melatonin receptor type 1A	MTNR1A	0.0052
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0052
362	Melatonin receptor type 1B	MTNR1B	0.0052
26	Vascular endothelial growth factor receptor 3	FLT4	0.0052
6163	Copper-transporting ATPase 2	ATP7B	0.0051
6165	Copper-transporting ATPase 1	ATP7A	0.0051
860	Nicotinamide N-methyltransferase	NNMT	0.0051
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0051
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0051
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0051
699	Nicotinic acid receptor 1	GPR109A	0.0051
928	Nicotinic acid receptor 2	GPR109B	0.0051
7	Nitric oxide synthase, inducible	NOS2	0.0051
6228	Nuclear receptor coactivator 1	NCOA1	0.0051
450	Muscarinic acetylcholine receptor M4	CHRM4	0.005
828	Phenylalanine-4-hydroxylase	PAH	0.005
3109	Phenylalanine-4-hydroxylase	phhA	0.005
6241	Nuclear receptor coactivator 2	NCOA2	0.005
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0049
32	Vascular endothelial growth factor receptor 1	FLT1	0.0049
5294	Nucleoside diphosphate kinase A	NME1	0.0049
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0048
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0048
558	Solute carrier family 12 member 1	SLC12A1	0.0048
33	Cystine/glutamate transporter	SLC7A11	0.0048
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0048
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0048
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0048
714	Glutathione reductase, mitochondrial	GSR	0.0047
4122	Histone deacetylase 2	HDAC2	0.0047
896	Glutathione S-transferase Mu 1	GSTM1	0.0046
2472	Voltage-gated potassium channel	kcsA	0.0046
6366	Voltage-gated potassium channel	kcsA	0.0046
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0046
6014	Cytochrome P450 2A13	CYP2A13	0.0046
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0046
6044	Serum paraoxonase/lactonase 3	PON3	0.0044
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0044
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0044
291	Nitric-oxide synthase, endothelial	NOS3	0.0043
504	Mast/stem cell growth factor receptor	KIT	0.0043
1517	Beta-3 adrenergic receptor	ADRB3	0.0042
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0042
163	D(1B) dopamine receptor	DRD5	0.0042
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0041
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0041
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.004
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.004
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.004
407	Vascular endothelial growth factor receptor 2	KDR	0.0039
6149	Solute carrier family 22 member 10	SLC22A10	0.0039
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0039
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0038
2232	Interleukin-5	IL5	0.0037
1593	Mucin-2	MUC2	0.0037
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0037
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0037
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0037
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0037
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0037
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0037
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0036
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0036
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0036
5126	Arginase	rocF	0.0036
164	Histamine H4 receptor	HRH4	0.0035
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0035
740	Argininosuccinate synthase	ASS1	0.0035
865	Argininosuccinate synthase	ASS1	0.0035
2680	Argininosuccinate synthase	argG	0.0035
3194	Argininosuccinate synthase	argG	0.0035
461	Glycine receptor subunit alpha-3	GLRA3	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0034
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0034
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0034
565	Extracellular calcium-sensing receptor	CASR	0.0034
1341	Histamine H3 receptor	HRH3	0.0034
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0034
712	Tubulin alpha chain	TUB1	0.0034
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0034
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0034
751	Potassium channel subfamily K member 6	KCNK6	0.0034
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0034
165	FL cytokine receptor	FLT3	0.0034
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0034
357	Carbonic anhydrase 2	CA2	0.0033
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0033
976	Platelet glycoprotein IX	GP9	0.0033
5923	Microtubule-associated protein tau	MAPT	0.0033
5924	Microtubule-associated protein 4	MAP4	0.0033
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0033
844	Epidermal growth factor receptor	EGFR	0.0033
260	Cytochrome P450 51	ERG11	0.0033
761	Cytochrome P450 51	ERG11	0.0033
3163	Cytochrome P450 51	cyp51	0.0033
499	Arginine decarboxylase	ADC	0.0033
613	Atrial natriuretic peptide receptor A	NPR1	0.0033
1650	Heme carrier protein 1	SLC46A1	0.0033
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0032
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0032
1714	Mitogen-activated protein kinase 3	MAPK3	0.0032
146	Androgen receptor	AR	0.0032
500	Monocarboxylate transporter 4	SLC16A3	0.0032
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0032
1123	Eosinophil cationic protein	RNASE3	0.0031
172	Potassium channel subfamily K member 1	KCNK1	0.0031
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0031
2449	Tubulin alpha-3 chain	TUBA1A	0.0031
6031	Cytochrome P450 3A43	CYP3A43	0.0031
577	Argininosuccinate lyase	ASL	0.0031
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0031
1852	Microtubule-associated protein 2	MAP2	0.0031
489	Monocarboxylate transporter 2	SLC16A7	0.0031
834	Arginase-2, mitochondrial	ARG2	0.0031
818	50S ribosomal protein L10	rplJ	0.003
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
173	Toll-like receptor 7	TLR7	0.003
150	Cationic amino acid transporter 3	SLC7A3	0.003
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.003
58	Cationic amino acid transporter 4	SLC7A4	0.003
6218	Pannexin-1	PANX1	0.003
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0029
3810	Catechol O-methyltransferase	COMT	0.0029
284	DNA-directed RNA polymerase beta chain	rpoB	0.0029
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0029
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0029
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0028
6167	Organic solute transporter subunit beta	OSTB	0.0028
6166	Organic solute transporter subunit alpha	OSTA	0.0028
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0028
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0028
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0028
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0028
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0028
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0028
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0028
543	Penicillin-binding protein 1B	mrcB	0.0028
6186	Penicillin-binding protein 1B	ponB	0.0028
6822	Penicillin-binding protein 1b	pbp1b	0.0028
6844	Penicillin-binding protein 1b	pbp1b	0.0028
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0028
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0027
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0027
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
871	Glucocorticoid receptor	NR3C1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0027
6020	Aldehyde oxidase	AOX1	0.0027
1569	G1/S-specific cyclin-D1	CCND1	0.0027
551	Carnitine O-acetyltransferase	CRAT	0.0027
29	Tubulin beta-1 chain	TUBB1	0.0026
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0026
6432	Transporter	snf	0.0026
4203	Histamine N-methyltransferase	HNMT	0.0026
94	5-hydroxytryptamine 4 receptor	HTR4	0.0025
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0025
1760	Aminopeptidase N	ANPEP	0.0025
6843	Aminopeptidase N	pepN	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
76	Nitric-oxide synthase, brain	NOS1	0.0025
6211	Tubulin epsilon chain	TUBE1	0.0024
6210	Tubulin delta chain	TUBD1	0.0024
6212	Tubulin gamma-1 chain	TUBG1	0.0024
6070	Nischarin	NISCH	0.0024
6085	Fatty acid-binding protein, intestinal	FABP2	0.0023
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0023
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
153	Dopamine beta-hydroxylase	DBH	0.0023
3957	Adenosine deaminase	ADA	0.0023
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0023
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0023
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0022
1039	Histone deacetylase 9	HDAC9	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0021
6043	Putative G-protein coupled receptor 44	GPR44	0.0021
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0021
921	Glutamate receptor 2	GRIA2	0.0021
2300	Lysozyme	E	0.0021
3633	Lysozyme	R	0.0021
5597	Lysozyme	17	0.0021
1192	Sulfotransferase 1A1	SULT1A1	0.0021
1360	Sphingomyelin phosphodiesterase	SMPD1	0.002
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.002
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.002
5682	Ribonuclease pancreatic	RNASE1	0.002
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.002
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.002
769	High-affinity choline transporter 1	SLC5A7	0.002
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.002
861	Choline kinase alpha	CHKA	0.002
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.002
700	Choline dehydrogenase, mitochondrial	CHDH	0.002
3927	Choline transporter-like protein 3	SLC44A3	0.002
1686	Choline transporter-like protein 1	SLC44A1	0.002
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.002
3926	Choline transporter-like protein 2	SLC44A2	0.002
3925	Choline transporter-like protein 4	SLC44A4	0.002
576	Choline O-acetyltransferase	CHAT	0.002
3922	Phospholipase D2	PLD2	0.002
3924	Phospholipase D1	PLD1	0.002
1820	Beta-nerve growth factor	NGF	0.002
1630	Integrin beta-2	ITGB2	0.002
3587	Gastrotropin	FABP6	0.002
4228	Keratin, type II cytoskeletal 7	KRT7	0.002
132	ATP-binding cassette sub-family A member 1	ABCA1	0.002
716	5-hydroxytryptamine 7 receptor	HTR7	0.0019
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0019
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0019
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0019
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0019
6837	Serine/threonine-protein kinase 17B	STK17B	0.0019
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0019
6151	Monocarboxylate transporter 10	SLC16A10	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
122	P2Y purinoceptor 12	P2RY12	0.0018
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0018
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0018
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0018
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0018
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0018
1176	Mitogen-activated protein kinase 1	MAPK1	0.0018
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0017
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0017
1648	Elastin	ELN	0.0017
1656	CYP2B protein	CYP2B	0.0017
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0017
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0016
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0016
1830	5'-nucleotidase	NT5E	0.0016
390	Adenosine A3 receptor	ADORA3	0.0016
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0016
1243	Cathepsin D	CTSD	0.0016
1010	Cytochrome P450 51A1	CYP51A1	0.0016
702	UMP-CMP kinase	CMPK1	0.0016
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0016
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0016
427	Substance-P receptor	TACR1	0.0016
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0015
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0015
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0015
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0015
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0015
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0015
365	Dihydrofolate reductase	DHFR	0.0015
2381	Dihydrofolate reductase	DFR1	0.0015
2833	Dihydrofolate reductase	Not Available	0.0015
2931	Dihydrofolate reductase	folA	0.0015
3544	Dihydrofolate reductase	folA	0.0015
3682	Dihydrofolate reductase	folA	0.0015
6642	Dihydrofolate reductase	folA	0.0015
6756	Dihydrofolate reductase	dfrA	0.0015
2499	Tubulin beta-2C chain	TUBB2C	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0015
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0015
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0015
572	Integrin alpha-L	ITGAL	0.0015
2599	Tyrosine-protein kinase HCK	HCK	0.0015
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0014
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0014
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0014
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0014
484	Tyrosine-protein kinase ABL2	ABL2	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0014
6102	Arylamine N-acetyltransferase 2	NAT2	0.0014
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0014
1313	Lactoylglutathione lyase	GLO1	0.0014
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0014
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0014
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0014
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0014
2091	Endoplasmin	HSP90B1	0.0014
6859	Protein S100-A4	S100A4	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
847	Mu-type opioid receptor	OPRM1	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
4773	Deoxycytidine kinase	DCK	0.0013
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0013
756	Sex hormone-binding globulin	SHBG	0.0013
696	Kappa-type opioid receptor	OPRK1	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
4311	tRNA	TRDMT1	0.0012
4325	tRNA	trmD	0.0012
4328	tRNA	trmD	0.0012
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0012
518	Peroxidase/catalase T	katG	0.0012
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0011
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0011
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0011
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0011
5818	Folate receptor alpha	FOLR1	0.0011
6042	Prostaglandin reductase 2	PTGR2	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0011
563	Thyroid peroxidase	TPO	0.0011
340	Apoptotic protease-activating factor 1	APAF1	0.0011
84	Nuclear receptor 0B1	NR0B1	0.0011
517	Alcohol dehydrogenase 1C	ADH1C	0.0011
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0011
467	Delta-type opioid receptor	OPRD1	0.0011
2391	Ferrochelatase	hemH	0.0011
6502	Ferrochelatase	DKFZp686P18130	0.0011
1591	Ferrochelatase, mitochondrial	FECH	0.0011
634	Squalene monooxygenase	SQLE	0.001
7196	Squalene monooxygenase	ERG1	0.001
239	Coagulation factor X	F10	0.001
4237	50S ribosomal protein L22	rplV	0.001
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.001
469	Annexin A1	ANXA1	0.001
564	Cellular retinoic acid-binding protein 1	CRABP1	0.001
293	Gamma-glutamyl hydrolase	GGH	0.001
825	Arsenical pump-driving ATPase	ASNA1	0.001
3435	Arsenical pump-driving ATPase	arsA	0.001
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.001
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.001
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.001
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.001
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.001
733	Activin receptor type 1B	ACVR1B	0.001
154	AFG3-like protein 2	AFG3L2	0.001
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.001
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.001
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.001
395	ALK tyrosine kinase receptor	Not Available	0.001
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.001
859	Cellular retinoic acid-binding protein 2	CRABP2	0.001
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.001
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.001
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.001
823	Fibroblast growth factor receptor 2	FGFR2	0.001
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.001
6182	Cytochrome P450 2J2	CYP2J2	0.0009
780	Retinoic acid receptor RXR-gamma	RXRG	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0009
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0009
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0009
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0009
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0009
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0009
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0009
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0009
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0009
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0009
6559	Cytochrome c oxidase subunit 2	ctaC	0.0009
6669	Cytochrome c oxidase subunit 2	ctaC	0.0009
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0009
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0009
6558	Cytochrome c oxidase subunit 1	ctaD	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0009
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0009
292	Activin receptor type-1	ACVR1	0.0009
849	Activated CDC42 kinase 1	TNK2	0.0009
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0009
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0009
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0009
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0009
297	Adenylate cyclase type 1	ADCY1	0.0009
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0008
459	Retinoic acid receptor RXR-alpha	RXRA	0.0008
2540	Choloylglycine hydrolase	cbh	0.0008
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0008
88	Retinoic acid receptor RXR-beta	RXRB	0.0008
2236	Casein kinase II subunit alpha	CSNK2A1	0.0008
3830	Calreticulin	CALR	0.0008
162	Retinoic acid receptor gamma-1	RARG	0.0008
1618	High affinity nerve growth factor receptor	NTRK1	0.0008
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0008
6501	Fatty acid-binding protein, liver	FABP1	0.0008
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0008
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
6034	Hydroxyindole O-methyltransferase	ASMT	0.0008
6035	Nuclear receptor ROR-beta	RORB	0.0008
6036	Eosinophil peroxidase	EPX	0.0008
811	Translocator protein	TSPO	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
1374	Natriuretic peptides B	NPPB	0.0008
1827	Gap junction alpha-1 protein	GJA1	0.0008
1908	Vascular cell adhesion protein 1	VCAM1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
4103	Proteasome subunit beta type 2	PSMB2	0.0007
4102	Proteasome subunit beta type 5	PSMB5	0.0007
4101	Proteasome subunit beta type 1	PSMB1	0.0007
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0007
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0007
4034	Glutaredoxin-1	GLRX	0.0007
910	Epididymal secretory glutathione peroxidase	GPX5	0.0007
903	Glutathione S-transferase A5	GSTA5	0.0007
4037	Hypothetical protein	GPX1	0.0007
4297	Hypothetical protein	SP_1951	0.0007
4521	Hypothetical protein	BC_2969	0.0007
4540	Hypothetical protein	TM_1070	0.0007
4555	Hypothetical protein	MT1739	0.0007
4569	Hypothetical protein	mshD	0.0007
4578	Hypothetical protein	PA3270	0.0007
4747	Hypothetical protein	PA3967	0.0007
5177	Hypothetical protein	TM_0096	0.0007
5194	Hypothetical protein	PA1204	0.0007
5240	Hypothetical protein	Rv2991	0.0007
5370	Hypothetical protein	TM_1158	0.0007
5710	Hypothetical protein	Tb927.5.1360	0.0007
1928	Leukotriene C4 synthase	LTC4S	0.0007
4029	Microsomal glutathione S-transferase 3	MGST3	0.0007
4032	Microsomal glutathione S-transferase 1	MGST1	0.0007
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0007
4040	Glutathione peroxidase 7	GPX7	0.0007
907	Glutathione peroxidase 2	GPX2	0.0007
4038	Glutathione peroxidase 4	GPX4	0.0007
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0007
906	Glutathione peroxidase 1	GPX1	0.0007
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0007
4035	Glutathione S-transferase Mu 5	GSTM5	0.0007
4036	Glutathione peroxidase 6	GPX6	0.0007
900	Glutathione S-transferase A4	GSTA4	0.0007
911	Glutathione peroxidase 3	GPX3	0.0007
4042	Glutathione transferase omega-2	GSTO2	0.0007
4033	S-formylglutathione hydrolase	ESD	0.0007
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0007
952	Dipeptidyl peptidase 4	DPP4	0.0007
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0007
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0007
814	Ryanodine receptor 1	RYR1	0.0007
822	Aldose reductase	AKR1B1	0.0007
3809	Estrogen-related receptor gamma	ESRRG	0.0007
6021	Adenosine kinase	ADK	0.0007
661	ADP/ATP translocase 1	SLC25A4	0.0007
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0007
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0007
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0007
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
251	Alcohol dehydrogenase 1A	ADH1A	0.0007
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0007
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
898	Glutathione S-transferase A3	GSTA3	0.0007
705	Glutamate receptor 1	GRIA1	0.0007
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0007
897	Glutathione S-transferase kappa 1	GSTK1	0.0007
6500	Phospholipase A2	PLA2G1B	0.0007
909	Maleylacetoacetate isomerase	GSTZ1	0.0007
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
899	Glutathione S-transferase Mu 3	GSTM3	0.0006
905	Glutathione transferase omega-1	GSTO1	0.0006
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0006
820	Glycine receptor subunit alpha-2	GLRA2	0.0006
268	Adenosine A2b receptor	ADORA2B	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
4041	Microsomal glutathione S-transferase 2	MGST2	0.0006
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0006
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0006
444	Alcohol dehydrogenase 1B	ADH1B	0.0006
2165	Glutathione S-transferase Mu 2	GSTM2	0.0006
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0006
183	Vascular endothelial growth factor A	VEGFA	0.0006
207	Glutathione synthetase	GSS	0.0006
5269	Glutathione synthetase	gshB	0.0006
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
1864	RET proto-oncogene	RET	0.0006
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0006
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0006
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0006
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0006
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0006
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0006
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0006
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0006
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0006
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0006
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0006
901	Glutathione S-transferase Mu 4	GSTM4	0.0005
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0005
1275	Estrogen sulfotransferase	SULT1E1	0.0005
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0005
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0005
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0005
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0005
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0005
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0005
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
798	Osteocalcin	BGLAP	0.0005
5934	Cytochrome P450 26A1	CYP26A1	0.0005
1050	Bile salt sulfotransferase	SULT2A1	0.0005
3932	Glutathione S-transferase A2	GSTA2	0.0005
4031	Glutathione S-transferase A1	GSTA1	0.0005
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0005
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
3937	Fatty-acid amide hydrolase	FAAH	0.0005
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0005
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0004
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0004
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0004
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0004
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0004
295	Carbonic anhydrase 1	CA1	0.0004
54	Prothrombin	F2	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00978 - Lomefloxacin

Targets

Enzymes

Transporters

Predictions