DT-Web

DB00795 - Sulfasalazine


Identification
Name Sulfasalazine
Accession Number DB00795 (APRD00152, DB08518)
Type small molecule
Description A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 398.393
Groups approved
Monoisotopic Weight 398.068490268
Pharmacology
Indication For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
Mechanism of action The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical studies utilizing rectal administration of Sulfasalazine, SP and 5-ASA have indicated that the major therapeutic action may reside in the 5-ASA moiety. The relative contribution of the parent drug and the major metabolites in rheumatoid arthritis is unknown.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Azathioprine Sulfasalazine may increase the toxicity of thiopurine, azathioprine.
Azilsartan medoxomil Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Chlorpropamide Sulfonamide/sulfonylurea: possible hypoglycemia
Cyclosporine The sulfonamide decreases the effect of cyclosporine
Digoxin Sulfasalazine may decrease the effect of digoxin.
Mercaptopurine Sulfasalazine may increase the toxicity of thiopurine, mercaptopurine.
Thioguanine Sulfasalazine may increase the toxicity of thiopurine, thioguanine.
Food Interactions
  • Take with food.
  • May take Vitamin D.
  • Take with a full glass of water No iron, zinc or fluoride within 2 hours of taking this medication.

Targets


Arachidonate 5-lipoxygenase
Name Arachidonate 5-lipoxygenase
Gene Name ALOX5
Pharmacological action yes
Actions inhibitor
References
  • Nielsen OH, Bukhave K, Elmgreen J, Ahnfelt-Ronne I: Inhibition of 5-lipoxygenase pathway of arachidonic acid metabolism in human neutrophils by sulfasalazine and 5-aminosalicylic acid. Dig Dis Sci. 1987 Jun;32(6):577-82. - Pubmed
  • Allgayer H, Eisenburg J, Paumgartner G: Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine. Eur J Clin Pharmacol. 1984;26(4):449-51. - Pubmed
  • Sircar JC, Schwender CF, Carethers ME: Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis. Biochem Pharmacol. 1983 Jan 1;32(1):170-2. - Pubmed
DTHybrid score 0.4765
Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Mifflin RC, Saada JI, Di Mari JF, Valentich JD, Adegboyega PA, Powell DW: Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts. Mol Pharmacol. 2004 Feb;65(2):470-8. - Pubmed
  • Generini S, Fiori G, Matucci Cerinic M: Therapy of spondylarthropathy in inflammatory bowel disease. Clin Exp Rheumatol. 2002 Nov-Dec;20(6 Suppl 28):S88-94. - Pubmed
  • Distrutti E, Sediari L, Mencarelli A, Renga B, Orlandi S, Russo G, Caliendo G, Santagada V, Cirino G, Wallace JL, Fiorucci S: 5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity. J Pharmacol Exp Ther. 2006 Oct;319(1):447-58. Epub 2006 Jul 19. - Pubmed
  • Cipolla G, Crema F, Sacco S, Moro E, de Ponti F, Frigo G: Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: current perspectives. Pharmacol Res. 2002 Jul;46(1):1-6. - Pubmed
  • Pruzanski W, Stefanski E, Vadas P, Ramamurthy NS: Inhibition of extracellular release of proinflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine: a novel mechanism of anti-inflammatory activity. Biochem Pharmacol. 1997 Jun 15;53(12):1901-7. - Pubmed
DTHybrid score 0.6841
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Pharmacological action yes
Actions inhibitor
References
  • Allgayer H: Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease. Aliment Pharmacol Ther. 2003 Sep;18 Suppl 2:10-4. - Pubmed
DTHybrid score 0.768
Peroxisome proliferator-activated receptor gamma
Name Peroxisome proliferator-activated receptor gamma
Gene Name PPARG
Pharmacological action yes
Actions agonist
References
  • Rousseaux C, Lefebvre B, Dubuquoy L, Lefebvre P, Romano O, Auwerx J, Metzger D, Wahli W, Desvergne B, Naccari GC, Chavatte P, Farce A, Bulois P, Cortot A, Colombel JF, Desreumaux P: Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J Exp Med. 2005 Apr 18;201(8):1205-15. Epub 2005 Apr 11. - Pubmed
  • Schwab M, Reynders V, Loitsch S, Shastri YM, Steinhilber D, Schroder O, Stein J: PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells. Carcinogenesis. 2008 Jul;29(7):1407-14. Epub 2008 Jun 9. - Pubmed
  • Linard C, Gremy O, Benderitter M: Reduction of peroxisome proliferation-activated receptor gamma expression by gamma-irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5-aminosalicylic acid agonist. J Pharmacol Exp Ther. 2008 Mar;324(3):911-20. Epub 2007 Dec 12. - Pubmed
  • Desreumaux P, Ghosh S: Review article: mode of action and delivery of 5-aminosalicylic acid - new evidence. Aliment Pharmacol Ther. 2006 Sep;24 Suppl 1:2-9. - Pubmed
DTHybrid score 1.1119
Inhibitor of nuclear factor kappa-B kinase subunit alpha
Name Inhibitor of nuclear factor kappa-B kinase subunit alpha
Gene Name CHUK
Pharmacological action unknown
Actions inhibitor
References
  • Weber CK, Liptay S, Wirth T, Adler G, Schmid RM: Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta. Gastroenterology. 2000 Nov;119(5):1209-18. - Pubmed
  • Allgayer H: Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease. Aliment Pharmacol Ther. 2003 Sep;18 Suppl 2:10-4. - Pubmed
DTHybrid score Not Available
Inhibitor of nuclear factor kappa-B kinase subunit beta
Name Inhibitor of nuclear factor kappa-B kinase subunit beta
Gene Name IKBKB
Pharmacological action unknown
Actions inhibitor
References
  • Weber CK, Liptay S, Wirth T, Adler G, Schmid RM: Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta. Gastroenterology. 2000 Nov;119(5):1209-18. - Pubmed
  • Allgayer H: Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease. Aliment Pharmacol Ther. 2003 Sep;18 Suppl 2:10-4. - Pubmed
DTHybrid score 0.437
Cystine/glutamate transporter
Name Cystine/glutamate transporter
Gene Name SLC7A11
Pharmacological action unknown
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Gout PW, Buckley AR, Simms CR, Bruchovsky N: Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug. Leukemia. 2001 Oct;15(10):1633-40. - Pubmed
DTHybrid score 0.3765
Acetyl-CoA acetyltransferase, mitochondrial
Name Acetyl-CoA acetyltransferase, mitochondrial
Gene Name ACAT1
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Faison LD, White HL: Sulfasalazine inhibits lyso-PAF: acetyl-COA acetyltransferase. Prostaglandins. 1992 Sep;44(3):245-9. - Pubmed
DTHybrid score 0.3098

Enzymes


Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2854

Transporters


ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate,inhibitor
References
  • Karlsson JE, Heddle C, Rozkov A, Rotticci-Mulder J, Tuvesson O, Hilgendorf C, Andersson TB: High-activity p-glycoprotein, multidrug resistance protein 2, and breast cancer resistance protein membrane vesicles prepared from transiently transfected human embryonic kidney 293-epstein-barr virus nuclear antigen cells. Drug Metab Dispos. 2010 Apr;38(4):705-14. Epub 2010 Jan 13. - Pubmed
  • Shukla S, Zaher H, Hartz A, Bauer B, Ware JA, Ambudkar SV: Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7. Epub 2008 Oct 9. - Pubmed
  • Dahan A, Amidon GL: Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7. Epub 2009 Jun 18. - Pubmed
DTHybrid score 0.3386
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate
References
  • Dahan A, Amidon GL: Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7. Epub 2009 Jun 18. - Pubmed
DTHybrid score 0.3136
Heme carrier protein 1
Name Heme carrier protein 1
Gene Name SLC46A1
Actions inhibitor
References
  • Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H: Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. J Pharmacol Exp Ther. 2007 Aug;322(2):469-76. Epub 2007 May 2. - Pubmed
DTHybrid score 0.4637

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2511
4757 Cytochrome P450 2C9 CYP2C9 0.2167
1588 Multidrug resistance protein 1 ABCB1 0.1947
587 Serum albumin ALB 0.1518
4924 Cytochrome P450 2C8 CYP2C8 0.1443
4200 Cytochrome P450 1A2 CYP1A2 0.1376
6016 Cytochrome P450 2C19 CYP2C19 0.1306
1729 Solute carrier family 22 member 6 SLC22A6 0.1206
6107 Cytochrome P450 3A7 CYP3A7 0.1196
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1171
365 Dihydrofolate reductase DHFR 0.1143
2381 Dihydrofolate reductase DFR1 0.1143
2833 Dihydrofolate reductase Not Available 0.1143
2931 Dihydrofolate reductase folA 0.1143
3544 Dihydrofolate reductase folA 0.1143
3682 Dihydrofolate reductase folA 0.1143
6642 Dihydrofolate reductase folA 0.1143
6756 Dihydrofolate reductase dfrA 0.1143
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1086
1757 Myeloperoxidase MPO 0.1039
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.1013
4119 Cytochrome P450 2D6 CYP2D6 0.0915
2164 Multidrug resistance-associated protein 4 ABCC4 0.0908
862 Multidrug resistance-associated protein 1 ABCC1 0.0906
6024 Cytochrome P450 1A1 CYP1A1 0.0892
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0725
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0667
6013 Cytochrome P450 2E1 CYP2E1 0.063
6142 Solute carrier family 22 member 8 SLC22A8 0.0599
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0598
6030 Cytochrome P450 2B6 CYP2B6 0.0593
6182 Cytochrome P450 2J2 CYP2J2 0.0558
776 Bile salt export pump ABCB11 0.0556
293 Gamma-glutamyl hydrolase GGH 0.0551
703 NADPH azoreductase azr 0.0549
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0536
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0512
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0507
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0487
38 Cystinosin CTNS 0.0485
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0485
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0485
6228 Nuclear receptor coactivator 1 NCOA1 0.048
1898 Cytochrome P450 1B1 CYP1B1 0.0478
1024 Solute carrier family 22 member 11 SLC22A11 0.0468
718 Folate receptor gamma FOLR3 0.0443
299 Folate receptor beta FOLR2 0.0443
804 Mitochondrial folate transporter/carrier SLC25A32 0.0443
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0415
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0411
6148 Multidrug resistance-associated protein 7 ABCC10 0.0402
6143 Solute carrier family 22 member 7 SLC22A7 0.04
5718 Cytochrome P450 2A6 CYP2A6 0.0395
3923 Cholinesterase BCHE 0.0387
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0383
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0383
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0383
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0363
1569 G1/S-specific cyclin-D1 CCND1 0.035
3917 Methylenetetrahydrofolate reductase MTHFR 0.0348
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0348
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0345
738 Monocarboxylate transporter 1 SLC16A1 0.0344
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0326
459 Retinoic acid receptor RXR-alpha RXRA 0.0323
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0309
70 Type-1 angiotensin II receptor AGTR1 0.0308
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0306
1629 Transcription factor AP-1 JUN 0.0305
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0302
1714 Mitogen-activated protein kinase 3 MAPK3 0.0299
6145 Solute carrier family 22 member 1 SLC22A1 0.0298
6241 Nuclear receptor coactivator 2 NCOA2 0.0297
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0296
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0292
6137 Multidrug resistance-associated protein 6 ABCC6 0.028
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.027
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.027
6106 Cytochrome P450 2C18 CYP2C18 0.0268
6141 Sodium/bile acid cotransporter SLC10A1 0.0263
817 DNA topoisomerase 2-alpha TOP2A 0.0262
6151 Monocarboxylate transporter 10 SLC16A10 0.0258
6144 Solute carrier family 22 member 2 SLC22A2 0.0257
3312 Fatty acid-binding protein, brain FABP7 0.0243
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0241
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.023
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0218
373 Transthyretin TTR 0.021
118 Organic cation/carnitine transporter 2 SLC22A5 0.0204
850 Vasopressin V1b receptor AVPR1B 0.0204
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.02
1507 Cytochrome c CYCS 0.0197
1176 Mitogen-activated protein kinase 1 MAPK1 0.0191
5818 Folate receptor alpha FOLR1 0.0189
1159 Interleukin-6 IL6 0.0185
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0181
6220 Aryl hydrocarbon receptor AHR 0.018
844 Epidermal growth factor receptor EGFR 0.0179
185 Vasopressin V1a receptor AVPR1A 0.0179
322 Vasopressin V2 receptor AVPR2 0.0175
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0174
777 Tumor necrosis factor TNF 0.0173
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0172
504 Mast/stem cell growth factor receptor KIT 0.0162
904 Glutathione S-transferase P GSTP1 0.0161
3811 Cytochrome P450 19A1 CYP19A1 0.016
3947 Xanthine dehydrogenase/oxidase XDH 0.0157
1353 DNA topoisomerase 1 TOP1 0.0156
3552 DNA topoisomerase 1 topA 0.0156
13 Aminomethyltransferase, mitochondrial AMT 0.0154
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0151
908 Glutathione S-transferase theta-1 GSTT1 0.015
136 Estrogen receptor ESR1 0.0149
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0146
614 Progesterone receptor PGR 0.0146
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0145
24 Thymidylate synthase TMP1 0.0143
359 Thymidylate synthase TYMS 0.0143
2626 Thymidylate synthase thyA 0.0143
2729 Thymidylate synthase thyA 0.0143
5352 Thymidylate synthase THYA 0.0143
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0143
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0143
146 Androgen receptor AR 0.0142
6147 Solute carrier family 22 member 3 SLC22A3 0.0142
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.014
6031 Cytochrome P450 3A43 CYP3A43 0.0138
477 DNA topoisomerase 4 subunit A parC 0.0137
886 DNA topoisomerase 4 subunit A parC 0.0137
6226 DNA topoisomerase 4 subunit A parC 0.0137
404 DNA gyrase subunit A gyrA 0.0135
6224 DNA gyrase subunit A gyrA 0.0135
672 Prostaglandin F2-alpha receptor PTGFR 0.0135
228 Beta platelet-derived growth factor receptor PDGFRB 0.0133
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0133
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0133
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0132
737 Mineralocorticoid receptor NR3C2 0.0131
4604 Liver carboxylesterase 1 CES1 0.0124
468 Cytochrome P450 4A11 CYP4A11 0.0123
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0123
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.012
871 Glucocorticoid receptor NR3C1 0.0118
731 HIV-1 protease HIV-1 protease 0.0118
183 Vascular endothelial growth factor A VEGFA 0.0117
117 Sterol O-acyltransferase 1 SOAT1 0.0115
26 Vascular endothelial growth factor receptor 3 FLT4 0.0114
723 Cytosolic phospholipase A2 PLA2G4A 0.0113
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0113
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0112
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0112
759 Free fatty acid receptor 1 FFAR1 0.011
3587 Gastrotropin FABP6 0.011
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.011
6146 High affinity copper uptake protein 1 SLC31A1 0.0109
32 Vascular endothelial growth factor receptor 1 FLT1 0.0109
273 Apoptosis regulator Bcl-2 BCL2 0.0108
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0108
2443 Azurin azu 0.0108
6167 Organic solute transporter subunit beta OSTB 0.0107
6166 Organic solute transporter subunit alpha OSTA 0.0107
6012 Tryptophan 2,3-dioxygenase TDO2 0.0106
6020 Aldehyde oxidase AOX1 0.0105
6043 Putative G-protein coupled receptor 44 GPR44 0.0105
847 Mu-type opioid receptor OPRM1 0.0104
6136 Multidrug resistance-associated protein 5 ABCC5 0.0104
29 Tubulin beta-1 chain TUBB1 0.0103
407 Vascular endothelial growth factor receptor 2 KDR 0.0103
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0101
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0101
1654 Interleukin-1 beta IL1B 0.01
6163 Copper-transporting ATPase 2 ATP7B 0.0099
6085 Fatty acid-binding protein, intestinal FABP2 0.0099
6165 Copper-transporting ATPase 1 ATP7A 0.0099
4773 Deoxycytidine kinase DCK 0.0099
320 5-hydroxytryptamine 1A receptor HTR1A 0.0099
1439 Lactotransferrin LTF 0.0098
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0098
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0096
1053 BC269730_2 FADS1 0.0096
1395 Sodium/calcium exchanger 1 SLC8A1 0.0096
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0094
4192 DNA topoisomerase 2-beta TOP2B 0.0093
165 FL cytokine receptor FLT3 0.0092
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.009
4132 Chloride channel protein ClC-Ka CLCNKA 0.009
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.009
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.009
2539 Tubulin alpha-1 chain TUBA4A 0.0089
823 Fibroblast growth factor receptor 2 FGFR2 0.0089
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0088
6599 HTH-type transcriptional regulator ttgR ttgR 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
896 Glutathione S-transferase Mu 1 GSTM1 0.0086
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0086
2981 Phospholipase A2, membrane associated PLA2G2A 0.0086
232 Corticosteroid-binding globulin SERPINA6 0.0086
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0085
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0085
4120 NADPH--cytochrome P450 reductase POR 0.0085
824 Sodium-dependent serotonin transporter SLC6A4 0.0085
6102 Arylamine N-acetyltransferase 2 NAT2 0.0084
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0084
489 Monocarboxylate transporter 2 SLC16A7 0.0084
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0084
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0083
494 Caspase-1 CASP1 0.0083
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0082
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0082
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0082
1648 Elastin ELN 0.0082
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
5923 Microtubule-associated protein tau MAPT 0.008
5924 Microtubule-associated protein 4 MAP4 0.008
492 Histamine H1 receptor HRH1 0.0079
467 Delta-type opioid receptor OPRD1 0.0078
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0077
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0077
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0077
22 30S ribosomal protein S4 rpsD 0.0076
6714 30S ribosomal protein S4 rpsD 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
86 SEC14-like protein 4 SEC14L4 0.0075
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0075
833 Organic cation/carnitine transporter 1 SLC22A4 0.0075
375 SEC14-like protein 3 SEC14L3 0.0075
4076 Diacylglycerol kinase alpha DGKA 0.0075
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0075
7 Nitric oxide synthase, inducible NOS2 0.0075
1852 Microtubule-associated protein 2 MAP2 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
2808 Chloramphenicol acetyltransferase 3 cat3 0.0074
558 Solute carrier family 12 member 1 SLC12A1 0.0073
6149 Solute carrier family 22 member 10 SLC22A10 0.0072
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0072
696 Kappa-type opioid receptor OPRK1 0.0072
140 30S ribosomal protein S9 rpsI 0.0072
6719 30S ribosomal protein S9 rpsI 0.0072
6725 30S ribosomal protein S9 rpsI 0.0072
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0072
661 ADP/ATP translocase 1 SLC25A4 0.0071
811 Translocator protein TSPO 0.0071
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.007
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.007
905 Glutathione transferase omega-1 GSTO1 0.007
899 Glutathione S-transferase Mu 3 GSTM3 0.007
2077 Caspase-3 CASP3 0.0069
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0069
65 Matrix metalloproteinase-9 Not Available 0.0068
3932 Glutathione S-transferase A2 GSTA2 0.0067
992 Protein tyrosine kinase 2 beta PTK2B 0.0067
461 Glycine receptor subunit alpha-3 GLRA3 0.0067
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0066
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0066
831 D(2) dopamine receptor DRD2 0.0066
708 Alpha-tocopherol transfer protein TTPA 0.0065
1656 CYP2B protein CYP2B 0.0065
130 Prostacyclin synthase PTGIS 0.0065
705 Glutamate receptor 1 GRIA1 0.0065
283 SEC14-like protein 2 SEC14L2 0.0064
6500 Phospholipase A2 PLA2G1B 0.0064
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0063
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0063
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0063
5626 Nucleoside diphosphate kinase B NME2 0.0063
556 Alpha-1A adrenergic receptor ADRA1A 0.0063
3270 Elongation factor G fusA 0.0062
260 Cytochrome P450 51 ERG11 0.0062
761 Cytochrome P450 51 ERG11 0.0062
3163 Cytochrome P450 51 cyp51 0.0062
756 Sex hormone-binding globulin SHBG 0.0061
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0061
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0061
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0061
3823 Cytokine receptor common gamma chain IL2RG 0.0061
161 Tubulin beta chain TUBB 0.006
312 Tubulin beta chain TUB2 0.006
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
810 Heme oxygenase 1 HMOX1 0.006
3391 Heme oxygenase 1 pbsA1 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
997 Protein kinase C beta type PRKCB 0.0059
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0059
291 Nitric-oxide synthase, endothelial NOS3 0.0058
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0058
469 Annexin A1 ANXA1 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0056
5787 Angiopoietin-1 receptor TEK 0.0056
3601 Dihydropteroate synthase 1 folP1 0.0056
3807 Dihydropteroate synthase 1 folP1 0.0056
3808 Dihydropteroate synthase 2 folP2 0.0056
6033 High affinity interleukin-8 receptor A CXCR1 0.0056
869 Estrogen receptor beta ESR2 0.0056
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0056
2021 Thrombomodulin THBD 0.0056
6042 Prostaglandin reductase 2 PTGR2 0.0055
502 5-hydroxytryptamine 2A receptor HTR2A 0.0055
1970 Protein kinase C alpha type PRKCA 0.0055
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0055
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0054
1192 Sulfotransferase 1A1 SULT1A1 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
724 Interleukin-2 receptor alpha chain IL2RA 0.0053
717 Interleukin-2 receptor subunit beta IL2RB 0.0053
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0052
885 5-hydroxytryptamine 1B receptor HTR1B 0.0052
5294 Nucleoside diphosphate kinase A NME1 0.0052
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
106 Cannabinoid receptor 2 CNR2 0.0051
3809 Estrogen-related receptor gamma ESRRG 0.0051
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0051
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.005
632 Alpha-1B adrenergic receptor ADRA1B 0.005
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0049
68 Cannabinoid receptor 1 CNR1 0.0049
725 5-hydroxytryptamine 1D receptor HTR1D 0.0049
638 D(3) dopamine receptor DRD3 0.0049
1760 Aminopeptidase N ANPEP 0.0049
6843 Aminopeptidase N pepN 0.0049
828 Phenylalanine-4-hydroxylase PAH 0.0049
3109 Phenylalanine-4-hydroxylase phhA 0.0049
713 Sodium-dependent dopamine transporter SLC6A3 0.0049
1313 Lactoylglutathione lyase GLO1 0.0049
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0048
131 Synaptic vesicular amine transporter SLC18A2 0.0047
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0047
341 5-hydroxytryptamine 3 receptor HTR3A 0.0047
427 Substance-P receptor TACR1 0.0047
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0046
239 Coagulation factor X F10 0.0045
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0045
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0043
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0043
3856 Fibroblast growth factor receptor 3 FGFR3 0.0042
2236 Casein kinase II subunit alpha CSNK2A1 0.0042
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0042
1618 High affinity nerve growth factor receptor NTRK1 0.0041
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0041
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.004
1792 Tissue-type plasminogen activator PLAT 0.004
617 Muscarinic acetylcholine receptor M2 CHRM2 0.004
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.004
511 5-hydroxytryptamine 1F receptor HTR1F 0.004
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0039
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0039
318 Alpha-2A adrenergic receptor ADRA2A 0.0038
6837 Serine/threonine-protein kinase 17B STK17B 0.0038
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
4148 Serine/threonine-protein kinase mTOR MTOR 0.0037
2853 14 kDa fatty acid-binding protein Not Available 0.0037
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0036
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0036
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0036
822 Aldose reductase AKR1B1 0.0036
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0035
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0035
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0035
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0035
342 P protein [Includes: DNA-directed DNA polymerase P 0.0035
612 P protein [Includes: DNA-directed DNA polymerase P 0.0035
84 Nuclear receptor 0B1 NR0B1 0.0035
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0034
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0034
1912 Excitatory amino acid transporter 1 SLC1A3 0.0034
4019 Excitatory amino acid transporter 4 SLC1A6 0.0034
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0034
4026 Aspartyl aminopeptidase DNPEP 0.0034
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0034
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0034
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0034
4016 Excitatory amino acid transporter 5 SLC1A7 0.0034
4017 5-oxoprolinase OPLAH 0.0034
1047 Excitatory amino acid transporter 2 SLC1A2 0.0034
922 Glutamate receptor 4 GRIA4 0.0034
664 Glutamate decarboxylase 2 GAD2 0.0034
3890 Glutamate decarboxylase 2 GAD2 0.0034
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0034
4020 Glutamyl aminopeptidase ENPEP 0.0034
4027 Glutamate receptor delta-1 subunit GRID1 0.0034
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0034
927 Metabotropic glutamate receptor 8 GRM8 0.0034
925 Metabotropic glutamate receptor 4 GRM4 0.0034
926 Metabotropic glutamate receptor 7 GRM7 0.0034
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0034
4018 Glutamate receptor delta-2 subunit GRID2 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
6014 Cytochrome P450 2A13 CYP2A13 0.0034
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0034
936 Ephrin type-A receptor 2 EPHA2 0.0034
789 Alpha-1D adrenergic receptor ADRA1D 0.0034
921 Glutamate receptor 2 GRIA2 0.0034
3941 Amine oxidase [flavin-containing] A MAOA 0.0034
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0033
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0033
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0033
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0033
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0033
267 Plasminogen activator inhibitor 1 SERPINE1 0.0032
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0032
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
378 Alpha-2C adrenergic receptor ADRA2C 0.0032
6221 Steroid hormone receptor ERR1 ESRRA 0.0032
590 5-hydroxytryptamine 2C receptor HTR2C 0.0032
1864 RET proto-oncogene RET 0.0032
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0032
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0032
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0032
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0032
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0031
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0031
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0031
702 UMP-CMP kinase CMPK1 0.0031
625 Glutamate carboxypeptidase 2 FOLH1 0.0031
465 Calmodulin CALM1 0.003
766 Beta-2 adrenergic receptor ADRB2 0.003
484 Tyrosine-protein kinase ABL2 ABL2 0.003
1630 Integrin beta-2 ITGB2 0.003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.003
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.003
3810 Catechol O-methyltransferase COMT 0.003
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.003
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0029
5 Glutaminase liver isoform, mitochondrial GLS2 0.0029
917 Glutaminase kidney isoform, mitochondrial GLS 0.0029
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0029
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0029
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0029
5261 Phosphoribosylformylglycinamidine synthase purL 0.0029
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0029
716 5-hydroxytryptamine 7 receptor HTR7 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
2599 Tyrosine-protein kinase HCK HCK 0.0028
665 Phosphoserine aminotransferase PSAT1 0.0028
4652 Phosphoserine aminotransferase serC 0.0028
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0028
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0028
420 Glutamate decarboxylase 1 GAD1 0.0028
3900 Glutamate decarboxylase 1 GAD1 0.0028
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0028
23 D(1A) dopamine receptor DRD1 0.0028
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0028
6103 Arylamine N-acetyltransferase 1 NAT1 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0028
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0028
916 Metabotropic glutamate receptor 1 GRM1 0.0028
952 Dipeptidyl peptidase 4 DPP4 0.0028
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0027
923 Glutamate receptor 3 GRIA3 0.0027
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0027
380 Cytochrome P450 17A1 CYP17A1 0.0027
1063 Signal transducer and activator of transcription 5B STAT5B 0.0027
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0027
2216 Fibroblast growth factor receptor 4 FGFR4 0.0027
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0027
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0027
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0027
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0027
1671 Excitatory amino acid transporter 3 SLC1A1 0.0027
629 Alpha-2B adrenergic receptor ADRA2B 0.0026
4943 Cytochrome c6 petJ 0.0026
4905 Cytochrome c2 Not Available 0.0026
4939 Cytochrome c2 cycA 0.0026
4964 Cytochrome c2 cycA 0.0026
4979 Cytochrome c2 cycA 0.0026
6673 Cytochrome c2 cycA 0.0026
4934 Cytochrome c-551 nirM 0.0026
5218 Cytochrome c-551 nirM 0.0026
4947 Bacterial hemoglobin vhb 0.0026
4994 Hemoglobin-like protein HbO glbO 0.0026
4916 Cyanoglobin glbN 0.0026
4954 Soluble cytochrome b558 Not Available 0.0026
4942 Diheme cytochrome c napB napB 0.0026
4975 Cytochrome c-556 RPA3973 0.0026
4909 CooA protein cooA 0.0026
4925 Cytochrome c-type protein SHP shp 0.0026
3116 Bacterioferritin bfr 0.0026
4906 Bacterioferritin bfr 0.0026
4965 Bacterioferritin bfr 0.0026
4984 Neuroglobin NGB 0.0026
4998 Hemoglobin-like protein yjbI yjbI 0.0026
4915 Cytochrome c-550 psbV 0.0026
4959 Cytochrome c-550 psbV 0.0026
5216 Cytochrome c-550 psbV 0.0026
4936 Cytochrome c2 iso-2 Not Available 0.0026
4981 Iron-starvation protein PigA pigA 0.0026
528 5-hydroxytryptamine 1E receptor HTR1E 0.0026
4907 Cytochrome c-L moxG 0.0026
6865 Cytochrome c-L moxG 0.0026
4989 Cytochrome c551 peroxidase ccp 0.0026
5222 Cytochrome c551 peroxidase ccpA 0.0026
5000 HemO hemO 0.0026
644 Heme oxygenase 2 HMOX2 0.0026
4982 Heme oxygenase 2 pbsA2 0.0026
4961 Hemophore HasA hasA 0.0026
4764 Cytochrome P450 165C4 CYP165C4 0.0026
4935 Cytochrome c-554 cycA1 0.0026
4999 Cytochrome P450 165B3 CYP165B3 0.0026
4910 Cytoglobin CYGB 0.0026
4904 Cytochrome c family protein GSU1996 0.0026
4976 Apocytochrome f petA 0.0026
6407 Apocytochrome f petA 0.0026
4971 Nonaheme cytochrome c hmcA 0.0026
4937 Cytochrome oxidase subunit II rcoxA 0.0026
4926 Heme-based aerotactic transducer hemAT hemAT 0.0026
4972 P450cin cinA 0.0026
4931 Cytochrome P450 167A1 CYP167A1 0.0026
4960 Putative cytochrome P450-family protein SCO7417 0.0026
4903 Methyl-accepting chemotaxis protein Tar4 0.0026
4952 Catalase/peroxidase katA 0.0026
4922 Cytochrome c, putative SO_4144 0.0026
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0026
4993 Hydroxylamine oxidoreductase hao1 0.0026
3093 Catalase HPII katE 0.0026
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0026
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0026
432 D(4) dopamine receptor DRD4 0.0026
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0026
3877 Growth-inhibiting protein 18 GIG18 0.0026
2183 Fatty acid-binding protein, adipocyte FABP4 0.0026
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0026
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0026
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0026
76 Nitric-oxide synthase, brain NOS1 0.0026
1275 Estrogen sulfotransferase SULT1E1 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0026
54 Prothrombin F2 0.0026
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0026
426 Aspartate aminotransferase, mitochondrial GOT2 0.0026
768 FK506-binding protein 1A FKBP1A 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
5300 Antigen peptide transporter 1 TAP1 0.0025
1050 Bile salt sulfotransferase SULT2A1 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
763 Tyrosine aminotransferase TAT 0.0025
5493 Tyrosine aminotransferase Not Available 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0025
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0025
6044 Serum paraoxonase/lactonase 3 PON3 0.0025
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0024
310 Solute carrier family 12 member 2 SLC12A2 0.0024
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0024
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0024
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0024
3814 Complement C1r subcomponent C1R 0.0024
6211 Tubulin epsilon chain TUBE1 0.0024
6210 Tubulin delta chain TUBD1 0.0024
6212 Tubulin gamma-1 chain TUBG1 0.0024
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0024
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0024
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0024
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0024
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0024
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0024
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0024
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0024
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0024
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0024
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0024
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0024
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0024
3955 Cell division protein kinase 6 CDK6 0.0023
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0023
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0023
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0023
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0023
1770 Phospholipase C PLCL1 0.0023
2841 Phospholipase C plc 0.0023
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0023
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0023
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0023
3086 Plasmepsin-2 Not Available 0.0023
572 Integrin alpha-L ITGAL 0.0022
153 Dopamine beta-hydroxylase DBH 0.0022
3426 Glutamine synthetase glnA 0.0022
3987 Glutamine synthetase GLUL 0.0022
2782 Complement C1s subcomponent C1S 0.0022
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
634 Squalene monooxygenase SQLE 0.0022
7196 Squalene monooxygenase ERG1 0.0022
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0022
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0021
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
4122 Histone deacetylase 2 HDAC2 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
94 5-hydroxytryptamine 4 receptor HTR4 0.0021
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0021
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0021
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
6824 Tyrosine-protein kinase Lyn LYN 0.0021
6168 Solute carrier family 22 member 16 SLC22A16 0.002
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.002
1010 Cytochrome P450 51A1 CYP51A1 0.002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.002
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.002
4920 Peroxidase/catalase katG 0.002
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.002
193 Beta-1 adrenergic receptor ADRB1 0.002
1058 Cell division protein kinase 5 CDK5 0.002
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0019
2119 Cytochrome b5 CYB5A 0.0019
4948 Cytochrome c-553 Not Available 0.0019
4923 Cytochrome c3 DvMF_2499 0.0019
4945 Cytochrome c3 Not Available 0.0019
4949 Cytochrome c3 DVU_3171 0.0019
4968 Cytochrome c3 cytc3 0.0019
4997 Cytochrome c3 SO_2727 0.0019
5219 Cytochrome c3 cyd 0.0019
4990 PpcA ppcA 0.0019
4902 Nine-heme cytochrome c Ddes_2038 0.0019
3189 High-molecular-weight cytochrome c hmcA 0.0019
4289 Cytochrome P450 TT_P0059 0.0019
6262 Cytochrome P450 staP 0.0019
3570 Cytochrome P450 152A1 cypC 0.0019
4992 Cytochrome c peroxidase Not Available 0.0019
4988 Sulfite oxidase, mitochondrial SUOX 0.0019
2915 Sensor protein fixL fixL 0.0019
4944 Sensor protein fixL fixL 0.0019
3375 Acidic cytochrome c3 Not Available 0.0019
4385 Cytochrome c' Not Available 0.0019
4967 Cytochrome c' cycA 0.0019
5038 Cytochrome c' Not Available 0.0019
5223 Cytochrome c' cycP 0.0019
4813 Heme oxygenase hmuO 0.0019
5769 Heme oxygenase Not Available 0.0019
2230 Catalase CAT 0.0019
3249 Catalase katA 0.0019
3625 Catalase katA 0.0019
4539 Catalase katA 0.0019
4941 Catalase katB 0.0019
1256 5-hydroxytryptamine 6 receptor HTR6 0.0019
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0019
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0019
6131 Carbonic anhydrase 14 CA14 0.0019
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0019
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0019
891 Dihydropteroate synthase folP 0.0018
5359 Dihydropteroate synthase folP 0.0018
7175 Dihydropteroate synthase sulI 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
2112 Toll-like receptor 9 TLR9 0.0018
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0018
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0018
2449 Tubulin alpha-3 chain TUBA1A 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
1039 Histone deacetylase 9 HDAC9 0.0017
4217 Telomerase reverse transcriptase TERT 0.0017
3670 Soluble cytochrome b562 precursor cybC 0.0017
3411 Cytochrome P450 121 cyp121 0.0017
2617 Nitric oxide synthase oxygenase nos 0.0017
2701 Nitric oxide synthase oxygenase nos 0.0017
2207 Rhodopsin RHO 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
3291 Cytochrome c-552 cycA 0.0017
4927 Cytochrome c-552 nrfA 0.0017
4938 Cytochrome c-552 cycA 0.0017
4953 Cytochrome c-552 nrfA 0.0017
5217 Cytochrome c-552 cycM 0.0017
124 Histamine H2 receptor HRH2 0.0017
4386 Hemoglobin-like protein HbN glbN 0.0017
3102 Flavohemoprotein hmp 0.0017
4969 Flavohemoprotein hmp 0.0017
518 Peroxidase/catalase T katG 0.0016
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0016
4311 tRNA TRDMT1 0.0016
4325 tRNA trmD 0.0016
4328 tRNA trmD 0.0016
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0016
818 50S ribosomal protein L10 rplJ 0.0016
4103 Proteasome subunit beta type 2 PSMB2 0.0016
4102 Proteasome subunit beta type 5 PSMB5 0.0016
4101 Proteasome subunit beta type 1 PSMB1 0.0016
6174 50S ribosomal protein L32 rpmF 0.0016
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0016
4225 Uridine phosphorylase 1 UPP1 0.0016
4203 Histamine N-methyltransferase HNMT 0.0016
4238 50S ribosomal protein L4 rplD 0.0015
5578 50S ribosomal protein L4 rplD 0.0015
6173 50S ribosomal protein L4 rplD 0.0015
6219 50S ribosomal protein L4 rplD 0.0015
1196 Complement decay-accelerating factor CD55 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
1374 Natriuretic peptides B NPPB 0.0015
1827 Gap junction alpha-1 protein GJA1 0.0015
1908 Vascular cell adhesion protein 1 VCAM1 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0015
3127 Nitrite reductase nirS 0.0015
3284 Nitrite reductase nirS 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
284 DNA-directed RNA polymerase beta chain rpoB 0.0015
5773 DNA-directed RNA polymerase beta chain rpoB 0.0015
2972 6-deoxyerythronolide B hydroxylase eryF 0.0015
3221 Cytochrome c4 cc4 0.0015
6171 Solute carrier family 28 member 3 SLC28A3 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
1152 Glycogen phosphorylase, muscle form PYGM 0.0015
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0015
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
357 Carbonic anhydrase 2 CA2 0.0014
4608 Putative cytochrome P450 SCO1207 0.0014
4963 Putative cytochrome P450 SCO2884 0.0014
6254 Putative cytochrome P450 SCO6998 0.0014
4237 50S ribosomal protein L22 rplV 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
1525 Heparin-binding growth factor 2 FGF2 0.0014
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0014
358 Cystathionine beta-synthase CBS 0.0014
2320 Thymidine kinase, cytosolic TK1 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0013
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0013
122 P2Y purinoceptor 12 P2RY12 0.0013
693 Hemoglobin subunit beta HBB 0.0013
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0013
760 Fibroblast growth factor 1 FGF1 0.0013
6218 Pannexin-1 PANX1 0.0013
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
751 Potassium channel subfamily K member 6 KCNK6 0.0012
2417 Chloramphenicol acetyltransferase cat 0.0012
3278 Chloramphenicol acetyltransferase cat 0.0012
6268 Hydroxyacid oxidase 1 HAO1 0.0012
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
2810 Dr hemagglutinin structural subunit draA 0.0012
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0012
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0012
3913 Glutamic acid decarboxylase GAD65 0.0011
172 Potassium channel subfamily K member 1 KCNK1 0.0011
340 Apoptotic protease-activating factor 1 APAF1 0.0011
436 5-hydroxytryptamine 2B receptor HTR2B 0.0011
319 Opioid receptor, sigma 1 OPRS1 0.0011
2240 Cell division protein kinase 2 CDK2 0.0011
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
1483 Membrane copper amine oxidase AOC3 0.0011
2298 Cytochrome P450-cam camC 0.0011
976 Platelet glycoprotein IX GP9 0.001
163 D(1B) dopamine receptor DRD5 0.001
825 Arsenical pump-driving ATPase ASNA1 0.001
3435 Arsenical pump-driving ATPase arsA 0.001
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.001
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.001
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.001
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.001
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.001
733 Activin receptor type 1B ACVR1B 0.001
154 AFG3-like protein 2 AFG3L2 0.001
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.001
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.001
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.001
395 ALK tyrosine kinase receptor Not Available 0.001
814 Ryanodine receptor 1 RYR1 0.001
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0009
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0009
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0009
6493 Cytochrome c oxidase subunit 6C COX6C 0.0009
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0009
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0009
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0009
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0009
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0009
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0009
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0009
6559 Cytochrome c oxidase subunit 2 ctaC 0.0009
6669 Cytochrome c oxidase subunit 2 ctaC 0.0009
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0009
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0009
6558 Cytochrome c oxidase subunit 1 ctaD 0.0009
174 Sigma 1-type opioid receptor SIGMAR1 0.0009
292 Activin receptor type-1 ACVR1 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
849 Activated CDC42 kinase 1 TNK2 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0009
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0009
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0009
297 Adenylate cyclase type 1 ADCY1 0.0009
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0008
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0008
1184 Interferon beta IFNB1 0.0008
2540 Choloylglycine hydrolase cbh 0.0008
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0008
1517 Beta-3 adrenergic receptor ADRB3 0.0008
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0008
6501 Fatty acid-binding protein, liver FABP1 0.0008
16 Adenosine A1 receptor ADORA1 0.0008
1178 Adenosine A2a receptor ADORA2A 0.0008
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
740 Argininosuccinate synthase ASS1 0.0007
865 Argininosuccinate synthase ASS1 0.0007
2680 Argininosuccinate synthase argG 0.0007
3194 Argininosuccinate synthase argG 0.0007
611 Retinal dehydrogenase 1 ALDH1A1 0.0007
6021 Adenosine kinase ADK 0.0007
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0007
5934 Cytochrome P450 26A1 CYP26A1 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0007
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0006
3939 Amine oxidase [flavin-containing] B MAOB 0.0006
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0006
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
442 Envelope glycoprotein gp41 0.0006
4859 Envelope glycoprotein env 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
780 Retinoic acid receptor RXR-gamma RXRG 0.0006
4041 Microsomal glutathione S-transferase 2 MGST2 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
517 Alcohol dehydrogenase 1C ADH1C 0.0006
207 Glutathione synthetase GSS 0.0006
5269 Glutathione synthetase gshB 0.0006
88 Retinoic acid receptor RXR-beta RXRB 0.0006
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
162 Retinoic acid receptor gamma-1 RARG 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
2430 Chondroitinase B cslB 0.0005
4031 Glutathione S-transferase A1 GSTA1 0.0005
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
295 Carbonic anhydrase 1 CA1 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0004
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
958 Insulin-like growth factor 1 receptor IGF1R 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0002
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
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