DT-Web: DB00773

Identification

Name

Etoposide

Accession Number

DB00773 (APRD00239)

Type

small molecule

Description

A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

588.5566

Groups

approved

Monoisotopic Weight

588.18429111

Pharmacology

Indication

For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.

Mechanism of action

Etoposide inhibits DNA topoisomerase II, thereby inhibiting DNA re-ligation. This causes critical errors in DNA synthesis at the premitotic stage of cell division and can lead to apoptosis of the cancer cell. Etoposide is cell cycle dependent and phase specific, affecting mainly the S and G2 phases of cell division. Inhibition of the topoisomerase II alpha isoform results in the anti-tumour activity of etoposide. The drug is also capable of inhibiting the beta isoform but inhibition of this target is not associated with the anti-tumour activity. It is instead associated with the carcinogenic effect.

Absorption

Absorbed well, time to peak plasma concentration is 1-1.5 hrs. Mean bioavailability is 50% (range of 25% - 75%). Cmax and AUC values for orally administered etoposide capsules display intra- and inter-subject variability. There is no evidence of first-pass effect for etoposide.

Protein binding

97% protein bound.

Biotransformation

Primarily hepatic (through O-demethylation via the CYP450 3A4 isoenzyme pathway) with 40% excreted unchanged in the urine. Etoposide also undergoes glutathione and glucuronide conjugation which are catalyzed by GSTT1/GSTP1 and UGT1A1, respectively. Prostaglandin synthases are also responsible for the conversion of etoposide to O-demethylated metabolites (quinone).

Route of elimination

Etoposide is cleared by both renal and nonrenal processes, i.e., metabolism and biliary excretion. Glucuronide and/or sulfate conjugates of etoposide are also excreted in human urine. Biliary excretion of unchanged drug and/or metabolites is an important route of etoposide elimination as fecal recovery of radioactivity is 44% of the intravenous dose. 56% of the dose was in the urine, 45% of which was excreted as etoposide.

Toxicity

Side effects include alopecia, constipation, diarrhea, nausea and vomiting and secondary malignancies (leukemia).

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Aprepitant	Aprepitant may change levels of the chemotherapy agent, etoposide.
Cyclosporine	Cyclosporine may increase the therapeutic and adverse effects of etoposide.
Quinupristin	This combination presents an increased risk of toxicity
Telithromycin	Telithromycin may reduce clearance of Etoposide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Etoposide if Telithromycin is initiated, discontinued or dose changed.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of etoposide by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of etoposide if voriconazole is initiated, discontinued or dose changed.

Food Interactions

Grapefruit and grapefruit juice should be avoided throughout treatment as grapefruit can decrease serum levels of this product.

DNA topoisomerase 2-alpha
Name	DNA topoisomerase 2-alpha
Gene Name	TOP2A
Pharmacological action	yes
Actions	inhibitor
References	de Lucio B, Manuel V, Barrera-Rodriguez R: Characterization of human NSCLC cell line with innate etoposide-resistance mediated by cytoplasmic localization of topoisomerase II alpha. Cancer Sci. 2005 Nov;96(11):774-83. - Pubmed Lopez-Lazaro M, Pastor N, Azrak SS, Ayuso MJ, Austin CA, Cortes F: Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients. J Nat Prod. 2005 Nov;68(11):1642-5. - Pubmed Moneypenny CG, Shao J, Song Y, Gallagher EP: MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells. Carcinogenesis. 2006 Apr;27(4):874-81. Epub 2005 Dec 24. - Pubmed Uesaka T, Shono T, Kuga D, Suzuki SO, Niiro H, Miyamoto K, Matsumoto K, Mizoguchi M, Ohta M, Iwaki T, Sasaki T: Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity. J Neurooncol. 2007 Sep;84(2):119-29. Epub 2007 Mar 15. - Pubmed Winnicka K, Bielawski K, Bielawska A: Cardiac glycosides in cancer research and cancer therapy. Acta Pol Pharm. 2006 Mar-Apr;63(2):109-15. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.5942
DNA topoisomerase 2-beta
Name	DNA topoisomerase 2-beta
Gene Name	TOP2B
Pharmacological action	no
Actions	inhibitor
References	Azarova AM, Lyu YL, Lin CP, Tsai YC, Lau JY, Wang JC, Liu LF: Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11014-9. Epub 2007 Jun 19. - Pubmed
DTHybrid score	0.4505

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Kawashiro T, Yamashita K, Zhao XJ, Koyama E, Tani M, Chiba K, Ishizaki T: A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes. J Pharmacol Exp Ther. 1998 Sep;286(3):1294-300. - Pubmed
DTHybrid score	0.8913
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5924
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4749
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3695
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4807
UDP-glucuronosyltransferase 1-1
Name	UDP-glucuronosyltransferase 1-1
Gene Name	UGT1A1
Actions	substrate
References	Wen Z, Tallman MN, Ali SY, Smith PC: UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos. 2007 Mar;35(3):371-80. Epub 2006 Dec 6. - Pubmed
DTHybrid score	0.2755
Glutathione S-transferase theta-1
Name	Glutathione S-transferase theta-1
Gene Name	GSTT1
Actions	substrate
References	Mans DR, Lafleur MV, Westmijze EJ, Horn IR, Bets D, Schuurhuis GJ, Lankelma J, Retel J: Reactions of glutathione with the catechol, the ortho-quinone and the semi-quinone free radical of etoposide. Consequences for DNA inactivation. Biochem Pharmacol. 1992 Apr 15;43(8):1761-8. - Pubmed
DTHybrid score	0.1523
Glutathione S-transferase P
Name	Glutathione S-transferase P
Gene Name	GSTP1
Actions	substrate
References	Mans DR, Lafleur MV, Westmijze EJ, Horn IR, Bets D, Schuurhuis GJ, Lankelma J, Retel J: Reactions of glutathione with the catechol, the ortho-quinone and the semi-quinone free radical of etoposide. Consequences for DNA inactivation. Biochem Pharmacol. 1992 Apr 15;43(8):1761-8. - Pubmed
DTHybrid score	0.6143
Prostaglandin G/H synthase 2
Name	Prostaglandin G/H synthase 2
Gene Name	PTGS2
Actions	substrate
References	Haim N, Roman J, Nemec J, Sinha BK: Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26). Biochem Biophys Res Commun. 1986 Feb 26;135(1):215-20. - Pubmed
DTHybrid score	0.6061
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Haim N, Roman J, Nemec J, Sinha BK: Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26). Biochem Biophys Res Commun. 1986 Feb 26;135(1):215-20. - Pubmed
DTHybrid score	0.6691

Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	substrate,inhibitor
References	Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. - Pubmed Zehnpfennig B, Urbatsch IL, Galla HJ: Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. Biochemistry. 2009 May 26;48(20):4423-30. - Pubmed Zelcer N, Saeki T, Reid G, Beijnen JH, Borst P: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7. - Pubmed
DTHybrid score	0.2631
Multidrug resistance-associated protein 6
Name	Multidrug resistance-associated protein 6
Gene Name	ABCC6
Actions	substrate,inhibitor
References	Cai J, Daoud R, Alqawi O, Georges E, Pelletier J, Gros P: Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6). Biochemistry. 2002 Jun 25;41(25):8058-67. - Pubmed Belinsky MG, Chen ZS, Shchaveleva I, Zeng H, Kruh GD: Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 Nov 1;62(21):6172-7. - Pubmed
DTHybrid score	0.2538
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Gao J, Murase O, Schowen RL, Aube J, Borchardt RT: A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm Res. 2001 Feb;18(2):171-6. - Pubmed Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):765-72. - Pubmed Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed Guo A, Marinaro W, Hu P, Sinko PJ: Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63. - Pubmed Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. - Pubmed
DTHybrid score	0.7275
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	substrate,inhibitor
References	Heijn M, Hooijberg JH, Scheffer GL, Szabo G, Westerhoff HV, Lankelma J: Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. Biochim Biophys Acta. 1997 May 22;1326(1):12-22. - Pubmed Guo A, Marinaro W, Hu P, Sinko PJ: Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63. - Pubmed Godinot N, Iversen PW, Tabas L, Xia X, Williams DC, Dantzig AH, Perry WL 3rd: Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey. Mol Cancer Ther. 2003 Mar;2(3):307-16. - Pubmed Nunoya K, Grant CE, Zhang D, Cole SP, Deeley RG: Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1). Drug Metab Dispos. 2003 Aug;31(8):1016-26. - Pubmed Stride BD, Grant CE, Loe DW, Hipfner DR, Cole SP, Deeley RG: Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol. 1997 Sep;52(3):344-53. - Pubmed Wong IL, Chan KF, Tsang KH, Lam CY, Zhao Y, Chan TH, Chow LM: Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives. J Med Chem. 2009 Sep 10;52(17):5311-22. - Pubmed
DTHybrid score	0.4271
Multidrug resistance-associated protein 7
Name	Multidrug resistance-associated protein 7
Gene Name	ABCC10
Actions	substrate,inhibitor
References	Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol. 2003 Feb;63(2):351-8. - Pubmed Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD: Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Cancer Res. 2009 Jan 1;69(1):178-84. - Pubmed
DTHybrid score	0.2122
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate,inhibitor
References	Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):773-9. - Pubmed Guo A, Marinaro W, Hu P, Sinko PJ: Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63. - Pubmed
DTHybrid score	0.4746
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate
References	Wang X, Furukawa T, Nitanda T, Okamoto M, Sugimoto Y, Akiyama S, Baba M: Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Mol Pharmacol. 2003 Jan;63(1):65-72. - Pubmed Allen JD, Van Dort SC, Buitelaar M, van Tellingen O, Schinkel AH: Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein. Cancer Res. 2003 Mar 15;63(6):1339-44. - Pubmed
DTHybrid score	0.4912

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.5323
6016	Cytochrome P450 2C19	CYP2C19	0.3882
4119	Cytochrome P450 2D6	CYP2D6	0.3789
6107	Cytochrome P450 3A7	CYP3A7	0.285
6030	Cytochrome P450 2B6	CYP2B6	0.2433
6024	Cytochrome P450 1A1	CYP1A1	0.216
587	Serum albumin	ALB	0.2017
1729	Solute carrier family 22 member 6	SLC22A6	0.1863
6875	Type-2 restriction enzyme EcoRV	ecoRVR	0.1797
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1786
477	DNA topoisomerase 4 subunit A	parC	0.1737
886	DNA topoisomerase 4 subunit A	parC	0.1737
6226	DNA topoisomerase 4 subunit A	parC	0.1737
404	DNA gyrase subunit A	gyrA	0.1706
6224	DNA gyrase subunit A	gyrA	0.1706
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1705
2164	Multidrug resistance-associated protein 4	ABCC4	0.1666
776	Bile salt export pump	ABCB11	0.1531
1898	Cytochrome P450 1B1	CYP1B1	0.1424
5718	Cytochrome P450 2A6	CYP2A6	0.1402
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.1317
6144	Solute carrier family 22 member 2	SLC22A2	0.1257
896	Glutathione S-transferase Mu 1	GSTM1	0.116
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.107
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.106
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.1058
6142	Solute carrier family 22 member 8	SLC22A8	0.1011
118	Organic cation/carnitine transporter 2	SLC22A5	0.0954
6145	Solute carrier family 22 member 1	SLC22A1	0.095
3947	Xanthine dehydrogenase/oxidase	XDH	0.0911
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.091
1757	Myeloperoxidase	MPO	0.0906
6143	Solute carrier family 22 member 7	SLC22A7	0.0815
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0805
6163	Copper-transporting ATPase 2	ATP7B	0.0794
6165	Copper-transporting ATPase 1	ATP7A	0.0794
6146	High affinity copper uptake protein 1	SLC31A1	0.0775
6136	Multidrug resistance-associated protein 5	ABCC5	0.0767
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0752
6106	Cytochrome P450 2C18	CYP2C18	0.0747
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0734
1024	Solute carrier family 22 member 11	SLC22A11	0.0698
4031	Glutathione S-transferase A1	GSTA1	0.066
3811	Cytochrome P450 19A1	CYP19A1	0.066
275	Arachidonate 5-lipoxygenase	ALOX5	0.0647
6147	Solute carrier family 22 member 3	SLC22A3	0.0639
6141	Sodium/bile acid cotransporter	SLC10A1	0.0637
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0611
136	Estrogen receptor	ESR1	0.0574
4120	NADPH--cytochrome P450 reductase	POR	0.0561
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0552
3923	Cholinesterase	BCHE	0.0546
468	Cytochrome P450 4A11	CYP4A11	0.0541
161	Tubulin beta chain	TUBB	0.0538
312	Tubulin beta chain	TUB2	0.0538
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0533
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0524
824	Sodium-dependent serotonin transporter	SLC6A4	0.052
492	Histamine H1 receptor	HRH1	0.0518
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.051
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0494
901	Glutathione S-transferase Mu 4	GSTM4	0.049
871	Glucocorticoid receptor	NR3C1	0.0481
1353	DNA topoisomerase 1	TOP1	0.0467
3552	DNA topoisomerase 1	topA	0.0467
731	HIV-1 protease	HIV-1 protease	0.0444
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0432
556	Alpha-1A adrenergic receptor	ADRA1A	0.0423
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0419
738	Monocarboxylate transporter 1	SLC16A1	0.0414
831	D(2) dopamine receptor	DRD2	0.041
2539	Tubulin alpha-1 chain	TUBA4A	0.0407
833	Organic cation/carnitine transporter 1	SLC22A4	0.0396
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0396
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0389
4604	Liver carboxylesterase 1	CES1	0.0389
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0386
24	Thymidylate synthase	TMP1	0.0383
359	Thymidylate synthase	TYMS	0.0383
2626	Thymidylate synthase	thyA	0.0383
2729	Thymidylate synthase	thyA	0.0383
5352	Thymidylate synthase	THYA	0.0383
6085	Fatty acid-binding protein, intestinal	FABP2	0.0381
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0379
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0379
847	Mu-type opioid receptor	OPRM1	0.0379
504	Mast/stem cell growth factor receptor	KIT	0.0376
70	Type-1 angiotensin II receptor	AGTR1	0.0374
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0372
29	Tubulin beta-1 chain	TUBB1	0.0372
1313	Lactoylglutathione lyase	GLO1	0.0364
844	Epidermal growth factor receptor	EGFR	0.0361
373	Transthyretin	TTR	0.0355
146	Androgen receptor	AR	0.035
4773	Deoxycytidine kinase	DCK	0.0346
723	Cytosolic phospholipase A2	PLA2G4A	0.0344
6031	Cytochrome P450 3A43	CYP3A43	0.0341
273	Apoptosis regulator Bcl-2	BCL2	0.0335
467	Delta-type opioid receptor	OPRD1	0.0334
260	Cytochrome P450 51	ERG11	0.0333
761	Cytochrome P450 51	ERG11	0.0333
3163	Cytochrome P450 51	cyp51	0.0333
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.033
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0328
26	Vascular endothelial growth factor receptor 3	FLT4	0.0328
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0325
3759	Glutathione S-transferase	gst	0.0325
4541	Glutathione S-transferase	GST	0.0325
318	Alpha-2A adrenergic receptor	ADRA2A	0.0322
777	Tumor necrosis factor	TNF	0.0321
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.032
6220	Aryl hydrocarbon receptor	AHR	0.0317
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0317
614	Progesterone receptor	PGR	0.0315
696	Kappa-type opioid receptor	OPRK1	0.0314
32	Vascular endothelial growth factor receptor 1	FLT1	0.0313
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0312
103	Muscarinic acetylcholine receptor M1	CHRM1	0.031
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0305
4180	DNA-(apurinic or apyrimidinic site) lyase	APEX1	0.0305
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0302
3932	Glutathione S-transferase A2	GSTA2	0.03
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0299
766	Beta-2 adrenergic receptor	ADRB2	0.0297
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0292
51	Muscarinic acetylcholine receptor M3	CHRM3	0.029
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0288
407	Vascular endothelial growth factor receptor 2	KDR	0.0287
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0285
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0284
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0283
23	D(1A) dopamine receptor	DRD1	0.0283
33	Cystine/glutamate transporter	SLC7A11	0.0281
869	Estrogen receptor beta	ESR2	0.0279
1852	Microtubule-associated protein 2	MAP2	0.0278
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0278
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0276
5923	Microtubule-associated protein tau	MAPT	0.0275
5924	Microtubule-associated protein 4	MAP4	0.0275
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0274
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0273
1650	Heme carrier protein 1	SLC46A1	0.0273
6102	Arylamine N-acetyltransferase 2	NAT2	0.027
632	Alpha-1B adrenergic receptor	ADRA1B	0.0268
6026	Alcohol dehydrogenase 6	ADH6	0.0266
3941	Amine oxidase [flavin-containing] A	MAOA	0.0265
4041	Microsomal glutathione S-transferase 2	MGST2	0.0264
117	Sterol O-acyltransferase 1	SOAT1	0.0261
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0261
36	Insulin receptor	INSR	0.0258
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0258
5626	Nucleoside diphosphate kinase B	NME2	0.0258
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.025
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0247
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0246
465	Calmodulin	CALM1	0.0243
1629	Transcription factor AP-1	JUN	0.0241
3810	Catechol O-methyltransferase	COMT	0.024
185	Vasopressin V1a receptor	AVPR1A	0.0238
6043	Putative G-protein coupled receptor 44	GPR44	0.0237
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0236
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0235
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0234
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0234
322	Vasopressin V2 receptor	AVPR2	0.0233
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0233
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0232
6182	Cytochrome P450 2J2	CYP2J2	0.0232
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0231
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0231
6149	Solute carrier family 22 member 10	SLC22A10	0.023
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0229
193	Beta-1 adrenergic receptor	ADRB1	0.0226
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0226
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0223
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0223
3611	Cytidine deaminase	cdd	0.0223
3707	Cytidine deaminase	cdd	0.0223
4211	Cytidine deaminase	CDA	0.0223
737	Mineralocorticoid receptor	NR3C2	0.0222
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0221
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0221
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0218
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0218
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0215
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0215
811	Translocator protein	TSPO	0.0215
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0214
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0213
789	Alpha-1D adrenergic receptor	ADRA1D	0.0212
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0212
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0212
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0211
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0211
638	D(3) dopamine receptor	DRD3	0.0209
5294	Nucleoside diphosphate kinase A	NME1	0.0207
702	UMP-CMP kinase	CMPK1	0.0207
853	Farnesyl pyrophosphate synthetase	FDPS	0.0205
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0205
2443	Azurin	azu	0.0205
850	Vasopressin V1b receptor	AVPR1B	0.0204
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0203
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0203
992	Protein tyrosine kinase 2 beta	PTK2B	0.0202
713	Sodium-dependent dopamine transporter	SLC6A3	0.0202
3312	Fatty acid-binding protein, brain	FABP7	0.0199
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0198
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0197
2449	Tubulin alpha-3 chain	TUBA1A	0.0196
6210	Tubulin delta chain	TUBD1	0.0196
6212	Tubulin gamma-1 chain	TUBG1	0.0196
6211	Tubulin epsilon chain	TUBE1	0.0196
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0193
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0193
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0193
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0193
293	Gamma-glutamyl hydrolase	GGH	0.0192
6168	Solute carrier family 22 member 16	SLC22A16	0.0191
952	Dipeptidyl peptidase 4	DPP4	0.019
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0189
7	Nitric oxide synthase, inducible	NOS2	0.0188
756	Sex hormone-binding globulin	SHBG	0.0187
489	Monocarboxylate transporter 2	SLC16A7	0.0186
1159	Interleukin-6	IL6	0.0185
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0184
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0181
1192	Sulfotransferase 1A1	SULT1A1	0.018
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0179
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0178
5880	Thrombopoietin receptor	MPL	0.0178
232	Corticosteroid-binding globulin	SERPINA6	0.0177
380	Cytochrome P450 17A1	CYP17A1	0.0176
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0176
16	Adenosine A1 receptor	ADORA1	0.0175
6167	Organic solute transporter subunit beta	OSTB	0.0174
6166	Organic solute transporter subunit alpha	OSTA	0.0174
629	Alpha-2B adrenergic receptor	ADRA2B	0.0173
3939	Amine oxidase [flavin-containing] B	MAOB	0.0172
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0172
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0171
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0171
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.017
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0169
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0169
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0168
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0168
1760	Aminopeptidase N	ANPEP	0.0168
6843	Aminopeptidase N	pepN	0.0168
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0168
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0166
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0165
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0165
378	Alpha-2C adrenergic receptor	ADRA2C	0.0163
958	Insulin-like growth factor 1 receptor	IGF1R	0.0161
823	Fibroblast growth factor receptor 2	FGFR2	0.0161
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.016
3868	Calcineurin subunit B isoform 2	PPP3R2	0.016
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0159
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0159
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0158
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0158
319	Opioid receptor, sigma 1	OPRS1	0.0157
291	Nitric-oxide synthase, endothelial	NOS3	0.0157
6020	Aldehyde oxidase	AOX1	0.0156
899	Glutathione S-transferase Mu 3	GSTM3	0.0155
905	Glutathione transferase omega-1	GSTO1	0.0155
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
5898	Complement C3	C3	0.0154
6042	Prostaglandin reductase 2	PTGR2	0.0154
165	FL cytokine receptor	FLT3	0.0153
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0152
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0149
1178	Adenosine A2a receptor	ADORA2A	0.0148
1050	Bile salt sulfotransferase	SULT2A1	0.0148
207	Glutathione synthetase	GSS	0.0146
5269	Glutathione synthetase	gshB	0.0146
3587	Gastrotropin	FABP6	0.0146
5787	Angiopoietin-1 receptor	TEK	0.0146
1830	5'-nucleotidase	NT5E	0.0145
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0144
4122	Histone deacetylase 2	HDAC2	0.0143
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0142
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0142
122	P2Y purinoceptor 12	P2RY12	0.0141
936	Ephrin type-A receptor 2	EPHA2	0.0141
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.014
2409	Acetyl-CoA acetyltransferase, cytosolic	ACAT2	0.0139
6218	Pannexin-1	PANX1	0.0138
365	Dihydrofolate reductase	DHFR	0.0137
2381	Dihydrofolate reductase	DFR1	0.0137
2833	Dihydrofolate reductase	Not Available	0.0137
2931	Dihydrofolate reductase	folA	0.0137
3544	Dihydrofolate reductase	folA	0.0137
3682	Dihydrofolate reductase	folA	0.0137
6642	Dihydrofolate reductase	folA	0.0137
6756	Dihydrofolate reductase	dfrA	0.0137
6677	Myelin P2 protein	PMP2	0.0137
672	Prostaglandin F2-alpha receptor	PTGFR	0.0135
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0135
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0134
703	NADPH azoreductase	azr	0.0132
461	Glycine receptor subunit alpha-3	GLRA3	0.0132
284	DNA-directed RNA polymerase beta chain	rpoB	0.0131
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0131
818	50S ribosomal protein L10	rplJ	0.0131
3307	Acriflavine resistance protein B	acrB	0.013
2852	DNA mismatch repair protein mutL	mutL	0.013
1648	Elastin	ELN	0.0129
705	Glutamate receptor 1	GRIA1	0.0129
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0128
1928	Leukotriene C4 synthase	LTC4S	0.0128
4037	Hypothetical protein	GPX1	0.0128
4297	Hypothetical protein	SP_1951	0.0128
4521	Hypothetical protein	BC_2969	0.0128
4540	Hypothetical protein	TM_1070	0.0128
4555	Hypothetical protein	MT1739	0.0128
4569	Hypothetical protein	mshD	0.0128
4578	Hypothetical protein	PA3270	0.0128
4747	Hypothetical protein	PA3967	0.0128
5177	Hypothetical protein	TM_0096	0.0128
5194	Hypothetical protein	PA1204	0.0128
5240	Hypothetical protein	Rv2991	0.0128
5370	Hypothetical protein	TM_1158	0.0128
5710	Hypothetical protein	Tb927.5.1360	0.0128
906	Glutathione peroxidase 1	GPX1	0.0128
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0128
4029	Microsomal glutathione S-transferase 3	MGST3	0.0128
4034	Glutaredoxin-1	GLRX	0.0128
4032	Microsomal glutathione S-transferase 1	MGST1	0.0128
4042	Glutathione transferase omega-2	GSTO2	0.0128
903	Glutathione S-transferase A5	GSTA5	0.0128
900	Glutathione S-transferase A4	GSTA4	0.0128
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0128
4035	Glutathione S-transferase Mu 5	GSTM5	0.0128
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0128
907	Glutathione peroxidase 2	GPX2	0.0128
4040	Glutathione peroxidase 7	GPX7	0.0128
4036	Glutathione peroxidase 6	GPX6	0.0128
911	Glutathione peroxidase 3	GPX3	0.0128
910	Epididymal secretory glutathione peroxidase	GPX5	0.0128
4038	Glutathione peroxidase 4	GPX4	0.0128
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0128
432	D(4) dopamine receptor	DRD4	0.0128
4033	S-formylglutathione hydrolase	ESD	0.0128
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0128
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0126
76	Nitric-oxide synthase, brain	NOS1	0.0126
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0125
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0125
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0125
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0125
6014	Cytochrome P450 2A13	CYP2A13	0.0124
3856	Fibroblast growth factor receptor 3	FGFR3	0.0124
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0123
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0123
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0123
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0123
1656	CYP2B protein	CYP2B	0.0123
125	DNA polymerase beta	POLB	0.0123
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0122
4237	50S ribosomal protein L22	rplV	0.0121
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0121
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0121
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0121
714	Glutathione reductase, mitochondrial	GSR	0.0121
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0121
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.012
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
6171	Solute carrier family 28 member 3	SLC28A3	0.012
1010	Cytochrome P450 51A1	CYP51A1	0.0119
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
3809	Estrogen-related receptor gamma	ESRRG	0.0117
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0117
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0117
2517	Subtilisin BPN'	apr	0.0116
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0115
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0115
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0115
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0115
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0115
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0115
897	Glutathione S-transferase kappa 1	GSTK1	0.0114
716	5-hydroxytryptamine 7 receptor	HTR7	0.0114
898	Glutathione S-transferase A3	GSTA3	0.0114
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0114
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0114
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0113
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0113
1507	Cytochrome c	CYCS	0.0113
6138	Multidrug resistance protein 3	ABCB4	0.0113
3823	Cytokine receptor common gamma chain	IL2RG	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
299	Folate receptor beta	FOLR2	0.0112
718	Folate receptor gamma	FOLR3	0.0112
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0112
4238	50S ribosomal protein L4	rplD	0.0111
5578	50S ribosomal protein L4	rplD	0.0111
6173	50S ribosomal protein L4	rplD	0.0111
6219	50S ribosomal protein L4	rplD	0.0111
909	Maleylacetoacetate isomerase	GSTZ1	0.011
5818	Folate receptor alpha	FOLR1	0.0109
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0109
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0108
6432	Transporter	snf	0.0108
124	Histamine H2 receptor	HRH2	0.0108
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0108
94	5-hydroxytryptamine 4 receptor	HTR4	0.0108
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0107
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0107
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0107
613	Atrial natriuretic peptide receptor A	NPR1	0.0106
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0106
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0106
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0106
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0106
2596	Acetyl-CoA acetyltransferase	phbA	0.0105
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0104
4311	tRNA	TRDMT1	0.0104
4325	tRNA	trmD	0.0104
4328	tRNA	trmD	0.0104
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0104
427	Substance-P receptor	TACR1	0.0104
474	Acetylcholinesterase	ACHE	0.0103
2236	Casein kinase II subunit alpha	CSNK2A1	0.0103
1618	High affinity nerve growth factor receptor	NTRK1	0.0103
183	Vascular endothelial growth factor A	VEGFA	0.0101
239	Coagulation factor X	F10	0.01
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.01
2165	Glutathione S-transferase Mu 2	GSTM2	0.01
921	Glutamate receptor 2	GRIA2	0.01
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0099
2298	Cytochrome P450-cam	camC	0.0099
4221	Vascular endothelial growth factor	VEGF	0.0099
5816	Cadherin-5	CDH5	0.0099
469	Annexin A1	ANXA1	0.0099
4692	A/G-specific adenine glycosylase	mutY	0.0098
6044	Serum paraoxonase/lactonase 3	PON3	0.0098
1439	Lactotransferrin	LTF	0.0098
6228	Nuclear receptor coactivator 1	NCOA1	0.0098
724	Interleukin-2 receptor alpha chain	IL2RA	0.0097
717	Interleukin-2 receptor subunit beta	IL2RB	0.0097
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0097
6241	Nuclear receptor coactivator 2	NCOA2	0.0097
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
68	Cannabinoid receptor 1	CNR1	0.0094
1714	Mitogen-activated protein kinase 3	MAPK3	0.0094
558	Solute carrier family 12 member 1	SLC12A1	0.0094
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0092
2808	Chloramphenicol acetyltransferase 3	cat3	0.0092
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0091
2021	Thrombomodulin	THBD	0.009
4132	Chloride channel protein ClC-Ka	CLCNKA	0.009
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.009
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.009
6500	Phospholipase A2	PLA2G1B	0.009
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0089
444	Alcohol dehydrogenase 1B	ADH1B	0.0089
3601	Dihydropteroate synthase 1	folP1	0.0089
3807	Dihydropteroate synthase 1	folP1	0.0089
3808	Dihydropteroate synthase 2	folP2	0.0089
482	Glycine receptor subunit alpha-1	GLRA1	0.0088
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0088
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0088
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0088
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0088
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0088
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0087
1630	Integrin beta-2	ITGB2	0.0087
891	Dihydropteroate synthase	folP	0.0087
5359	Dihydropteroate synthase	folP	0.0087
7175	Dihydropteroate synthase	sulI	0.0087
782	ADP/ATP translocase 2	SLC25A5	0.0086
688	ADP/ATP translocase 3	SLC25A6	0.0086
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0086
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0085
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0082
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0082
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0082
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0081
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0081
1275	Estrogen sulfotransferase	SULT1E1	0.008
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.008
6837	Serine/threonine-protein kinase 17B	STK17B	0.008
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0079
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0079
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0079
2282	Protein recA	recA	0.0079
2315	Protein recA	recA	0.0079
2332	Protein recA	recA	0.0079
5263	Protein recA	recA	0.0079
5265	FtsH	ftsH	0.0079
5646	Galactokinase	GALK1	0.0079
5302	TrwB	trwB	0.0079
5645	DNA topoisomerase 4 subunit B	parE	0.0078
6227	DNA topoisomerase 4 subunit B	parE	0.0078
3794	Osmolarity sensor protein envZ	envZ	0.0078
5649	Potassium-transporting ATPase B chain	kdpB	0.0078
5643	General secretion pathway protein E	epsE	0.0078
5641	Rod shape-determining protein MreB	TM_0588	0.0078
4178	DNA repair protein RAD51 homolog 1	RAD51	0.0078
5642	Chaperone clpB	clpB	0.0078
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0078
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0078
5644	Sensor protein phoQ	phoQ	0.0078
2599	Tyrosine-protein kinase HCK	HCK	0.0078
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0078
814	Ryanodine receptor 1	RYR1	0.0077
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0077
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0077
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0077
4226	Uridine phosphorylase 2	UPP2	0.0076
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0075
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0075
5300	Antigen peptide transporter 1	TAP1	0.0075
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
661	ADP/ATP translocase 1	SLC25A4	0.0074
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0074
6459	Glycodelin	PAEP	0.0073
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0073
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0073
130	Prostacyclin synthase	PTGIS	0.0073
163	D(1B) dopamine receptor	DRD5	0.0072
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0071
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0071
790	DNA polymerase subunit alpha B	POLA2	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
3709	Glycerol uptake facilitator protein	glpF	0.0071
3116	Bacterioferritin	bfr	0.0071
4906	Bacterioferritin	bfr	0.0071
4965	Bacterioferritin	bfr	0.0071
6033	High affinity interleukin-8 receptor A	CXCR1	0.0071
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0071
3173	Enolase	eno	0.0071
3238	Multidrug resistance protein mexA	mexA	0.0071
3393	TGF-beta receptor type-2	TGFBR2	0.0071
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0071
4225	Uridine phosphorylase 1	UPP1	0.007
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.007
5312	Kinesin-like protein KIF1A	KIF1A	0.0069
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0069
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0069
283	SEC14-like protein 2	SEC14L2	0.0069
6433	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	PFKFB4	0.0069
4116	Dihydropteroate synthetase	Not Available	0.0069
2867	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	ispE	0.0068
517	Alcohol dehydrogenase 1C	ADH1C	0.0068
244	Angiotensin-converting enzyme	ACE	0.0068
4751	Mitogen-activated protein kinase 12	MAPK12	0.0068
2397	Dihydroxyacetone kinase	dhaK	0.0068
106	Cannabinoid receptor 2	CNR2	0.0068
1881	Hexokinase-1	HK1	0.0067
768	FK506-binding protein 1A	FKBP1A	0.0067
459	Retinoic acid receptor RXR-alpha	RXRA	0.0066
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0066
6766	O-GlcNAcase BT_4395	BT_4395	0.0066
413	Amidophosphoribosyltransferase	PPAT	0.0065
2515	Amidophosphoribosyltransferase	purF	0.0065
3714	Amidophosphoribosyltransferase	purF	0.0065
572	Integrin alpha-L	ITGAL	0.0065
2499	Tubulin beta-2C chain	TUBB2C	0.0065
153	Dopamine beta-hydroxylase	DBH	0.0065
131	Synaptic vesicular amine transporter	SLC18A2	0.0065
3221	Cytochrome c4	cc4	0.0064
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0064
84	Nuclear receptor 0B1	NR0B1	0.0064
2615	Chemotaxis protein cheA	cheA	0.0064
571	Melatonin receptor type 1A	MTNR1A	0.0064
2371	Pantothenate kinase	coaA	0.0064
362	Melatonin receptor type 1B	MTNR1B	0.0064
828	Phenylalanine-4-hydroxylase	PAH	0.0064
3109	Phenylalanine-4-hydroxylase	phhA	0.0064
2892	Acetylglutamate kinase	argB	0.0064
3550	Acetylglutamate kinase	argB	0.0064
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
3231	Death-associated protein kinase 1	DAPK1	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
2299	UDP-N-acetylmuramate--L-alanine ligase	murC	0.0063
1792	Tissue-type plasminogen activator	PLAT	0.0063
3270	Elongation factor G	fusA	0.0062
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0062
295	Carbonic anhydrase 1	CA1	0.0062
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0061
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0061
4103	Proteasome subunit beta type 2	PSMB2	0.0061
4102	Proteasome subunit beta type 5	PSMB5	0.0061
4101	Proteasome subunit beta type 1	PSMB1	0.0061
518	Peroxidase/catalase T	katG	0.006
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
134	Tryptophan 5-hydroxylase 1	TPH1	0.006
634	Squalene monooxygenase	SQLE	0.006
7196	Squalene monooxygenase	ERG1	0.006
2727	S-adenosylmethionine synthetase	metK	0.006
88	Retinoic acid receptor RXR-beta	RXRB	0.006
3937	Fatty-acid amide hydrolase	FAAH	0.006
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0059
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0059
997	Protein kinase C beta type	PRKCB	0.0059
887	DNA gyrase subunit B	gyrB	0.0059
4150	DNA gyrase subunit B	gyrB	0.0059
6225	DNA gyrase subunit B	gyrB	0.0059
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0059
1483	Membrane copper amine oxidase	AOC3	0.0058
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0058
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0058
3191	Histidinol dehydrogenase	hisD	0.0058
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0057
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0057
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0057
5798	Mitogen-activated protein kinase 11	MAPK11	0.0057
760	Fibroblast growth factor 1	FGF1	0.0057
1517	Beta-3 adrenergic receptor	ADRB3	0.0057
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
759	Free fatty acid receptor 1	FFAR1	0.0056
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0056
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0056
4203	Histamine N-methyltransferase	HNMT	0.0056
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0055
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0054
3639	Thymidine phosphorylase	deoA	0.0054
3936	Thymidine phosphorylase	TYMP	0.0054
676	Tyrosine 3-monooxygenase	TH	0.0054
6824	Tyrosine-protein kinase Lyn	LYN	0.0054
1970	Protein kinase C alpha type	PRKCA	0.0054
3086	Plasmepsin-2	Not Available	0.0053
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0053
357	Carbonic anhydrase 2	CA2	0.0053
6103	Arylamine N-acetyltransferase 1	NAT1	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
2112	Toll-like receptor 9	TLR9	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
54	Prothrombin	F2	0.0053
2802	Endoglucanase G	celCCG	0.0052
708	Alpha-tocopherol transfer protein	TTPA	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
4077	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	0.0052
712	Tubulin alpha chain	TUB1	0.0052
86	SEC14-like protein 4	SEC14L4	0.0052
2391	Ferrochelatase	hemH	0.0052
6502	Ferrochelatase	DKFZp686P18130	0.0052
1591	Ferrochelatase, mitochondrial	FECH	0.0052
375	SEC14-like protein 3	SEC14L3	0.0052
4076	Diacylglycerol kinase alpha	DGKA	0.0052
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0052
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0052
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0052
2251	Thymidylate kinase	tmk	0.0052
2254	Thymidylate kinase	DTYMK	0.0052
3522	Thymidylate kinase	tmk	0.0052
592	Carbonic anhydrase 4	CA4	0.0052
4752	Peroxisomal trans-2-enoyl-CoA reductase	PECR	0.0052
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
976	Platelet glycoprotein IX	GP9	0.0051
251	Alcohol dehydrogenase 1A	ADH1A	0.0051
2230	Catalase	CAT	0.0051
3249	Catalase	katA	0.0051
3625	Catalase	katA	0.0051
4539	Catalase	katA	0.0051
4941	Catalase	katB	0.0051
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.005
4078	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	0.005
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.005
162	Retinoic acid receptor gamma-1	RARG	0.005
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.005
1541	Metalloproteinase	mmp20	0.0049
1053	BC269730_2	FADS1	0.0049
1395	Sodium/calcium exchanger 1	SLC8A1	0.0049
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0049
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0049
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0048
6316	ADP-ribosylation factor 1	ARF1	0.0048
484	Tyrosine-protein kinase ABL2	ABL2	0.0048
6288	Low molecular weight phosphotyrosine protein phosphatase	ACP1	0.0048
6174	50S ribosomal protein L32	rpmF	0.0047
3957	Adenosine deaminase	ADA	0.0047
3822	Actin, alpha skeletal muscle	ACTA1	0.0047
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0047
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0047
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
810	Heme oxygenase 1	HMOX1	0.0047
3391	Heme oxygenase 1	pbsA1	0.0047
2216	Fibroblast growth factor receptor 4	FGFR4	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0046
1374	Natriuretic peptides B	NPPB	0.0046
1827	Gap junction alpha-1 protein	GJA1	0.0046
1908	Vascular cell adhesion protein 1	VCAM1	0.0046
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0046
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0046
173	Toll-like receptor 7	TLR7	0.0046
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0045
2232	Interleukin-5	IL5	0.0045
1593	Mucin-2	MUC2	0.0045
1864	RET proto-oncogene	RET	0.0045
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0045
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0045
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0045
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0045
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0045
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0045
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0045
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0045
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0045
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0045
6559	Cytochrome c oxidase subunit 2	ctaC	0.0045
6669	Cytochrome c oxidase subunit 2	ctaC	0.0045
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0045
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0045
6558	Cytochrome c oxidase subunit 1	ctaD	0.0045
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0045
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0045
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0045
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0045
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0045
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
1836	Mitogen-activated protein kinase 10	MAPK10	0.0045
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0044
267	Plasminogen activator inhibitor 1	SERPINE1	0.0044
856	Vitamin D3 receptor	VDR	0.0043
822	Aldose reductase	AKR1B1	0.0043
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0043
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0042
780	Retinoic acid receptor RXR-gamma	RXRG	0.0042
4606	Purine trans deoxyribosylase	ptd	0.0042
3913	Glutamic acid decarboxylase	GAD65	0.0042
2540	Choloylglycine hydrolase	cbh	0.0041
1569	G1/S-specific cyclin-D1	CCND1	0.0041
229	Retinoic acid receptor beta	RARB	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
3679	MTA/SAH nucleosidase	mtnN	0.004
1958	S-methyl-5-thioadenosine phosphorylase	MTAP	0.004
730	Retinoic acid receptor alpha	RARA	0.004
6221	Steroid hormone receptor ERR1	ESRRA	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.004
775	Acetyl-CoA carboxylase 2	ACACB	0.004
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0039
751	Potassium channel subfamily K member 6	KCNK6	0.0039
6501	Fatty acid-binding protein, liver	FABP1	0.0039
174	Sigma 1-type opioid receptor	SIGMAR1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
128	Adenine phosphoribosyltransferase	APRT	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
1123	Eosinophil cationic protein	RNASE3	0.0038
6131	Carbonic anhydrase 14	CA14	0.0037
594	Thyroxine-binding globulin	SERPINA7	0.0037
2207	Rhodopsin	RHO	0.0037
2853	14 kDa fatty acid-binding protein	Not Available	0.0037
1789	Lymphotoxin-alpha	LTA	0.0037
1269	Tumor necrosis factor receptor superfamily member 1B	TNFRSF1B	0.0037
4217	Telomerase reverse transcriptase	TERT	0.0036
6126	Carbonic anhydrase 7	CA7	0.0036
1196	Complement decay-accelerating factor	CD55	0.0036
563	Thyroid peroxidase	TPO	0.0036
172	Potassium channel subfamily K member 1	KCNK1	0.0036
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0036
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0036
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0036
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0036
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0036
3404	Exotoxin A	eta	0.0036
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0036
5448	Ribonuclease Z	rnz	0.0035
5449	Hypothetical gliding protein	mglB	0.0035
3781	Thiol:disulfide interchange protein dsbC precursor	dsbC	0.0035
4705	Manganese catalase	Not Available	0.0035
5439	33 kDa chaperonin	hslO	0.0035
332	Beta-lactamase	blaZ	0.0035
2478	Beta-lactamase	ampC	0.0035
2613	Beta-lactamase	ampC	0.0035
2635	Beta-lactamase	ampC	0.0035
2700	Beta-lactamase	penP	0.0035
5445	Beta-lactamase	blaB	0.0035
6019	Beta-lactamase	SHV-7	0.0035
6701	Beta-lactamase	cphA	0.0035
5443	UPF0189 protein ymdB	ymdB	0.0035
5446	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	HI_1679	0.0035
5440	UPF0067 protein yebR	yebR	0.0035
2720	Copper-containing nitrite reductase	nirK	0.0035
5454	Internalin-A	inlA	0.0035
5447	Lethal(3)malignant brain tumor-like protein	L3MBTL1	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0035
735	Alanine aminotransferase 1	GPT	0.0035
3904	Alanine aminotransferase 2	GPT2	0.0035
939	50S ribosomal protein L3	rplC	0.0035
758	Thyroid hormone receptor alpha	THRA	0.0034
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0034
4498	Ornithine cyclodeaminase	PP3533	0.0034
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0034
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0034
4608	Putative cytochrome P450	SCO1207	0.0033
4963	Putative cytochrome P450	SCO2884	0.0033
6254	Putative cytochrome P450	SCO6998	0.0033
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0033
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0032
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
65	Matrix metalloproteinase-9	Not Available	0.0031
5450	Prolyl endopeptidase Pep	pep	0.0031
4771	Dissimilatory copper-containing nitrite reductase	nir	0.0031
473	L-lactate dehydrogenase A chain	LDHA	0.0031
3356	Diaminopimelate decarboxylase	lysA	0.0031
2714	Chorismate mutase	aroH	0.0031
4611	Chorismate mutase	aroG	0.0031
1039	Histone deacetylase 9	HDAC9	0.0031
3274	Hydroxylamine reductase	hcp	0.0031
4804	Hydroxylamine reductase	hcp	0.0031
2264	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	cobT	0.0031
346	Thyroid hormone receptor beta-1	THRB	0.0031
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
543	Penicillin-binding protein 1B	mrcB	0.003
6186	Penicillin-binding protein 1B	ponB	0.003
6822	Penicillin-binding protein 1b	pbp1b	0.003
6844	Penicillin-binding protein 1b	pbp1b	0.003
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4228	Keratin, type II cytoskeletal 7	KRT7	0.003
159	Penicillin-binding protein 2B	penA	0.0029
6121	Penicillin-binding protein 2B	penA	0.0029
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
2320	Thymidine kinase, cytosolic	TK1	0.0029
268	Adenosine A2b receptor	ADORA2B	0.0029
2417	Chloramphenicol acetyltransferase	cat	0.0029
3278	Chloramphenicol acetyltransferase	cat	0.0029
358	Cystathionine beta-synthase	CBS	0.0029
3399	Limonene-1,2-epoxide hydrolase	limA	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
2810	Dr hemagglutinin structural subunit	draA	0.0029
3462	Tyrosine-protein kinase transforming protein Abl	ABL	0.0028
1525	Heparin-binding growth factor 2	FGF2	0.0028
2290	ADP-ribosyl cyclase 2	BST1	0.0028
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.0028
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0028
1291	cAMP response element-binding protein	CREB1	0.0028
1253	Interferon gamma	IFNG	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
597	Dihydropteridine reductase	QDPR	0.0028
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0027
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
199	Monocarboxylate transporter 8	SLC16A2	0.0027
4210	Toll-like receptor 4	TLR4	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
5180	L(+)-mandelate dehydrogenase	mdlB	0.0027
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0027
3500	Putative family 31 glucosidase yicI	yicI	0.0027
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0027
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
1262	Corticotropin-lipotropin	POMC	0.0027
6048	Troponin C, skeletal muscle	TNNC2	0.0026
577	Argininosuccinate lyase	ASL	0.0026
663	Solute carrier family 12 member 4	SLC12A4	0.0026
53	Solute carrier family 12 member 5	SLC12A5	0.0026
1615	Chymase	CMA1	0.0026
581	Cytochrome P450 2R1	CYP2R1	0.0026
49	Endothelin B receptor	EDNRB	0.0026
6859	Protein S100-A4	S100A4	0.0025
5934	Cytochrome P450 26A1	CYP26A1	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0025
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0025
310	Solute carrier family 12 member 2	SLC12A2	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
3814	Complement C1r subcomponent	C1R	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
287	Beta-1,4-galactosyltransferase 1	B4GALT1	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
3955	Cell division protein kinase 6	CDK6	0.0023
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0023
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0023
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0023
2782	Complement C1s subcomponent	C1S	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0022
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0022
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0022
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0022
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0022
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
2091	Endoplasmin	HSP90B1	0.0021
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0021
164	Histamine H4 receptor	HRH4	0.0021
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
3817	Complement C1q subcomponent subunit C	C1QC	0.0021
3815	Complement C1q subcomponent subunit A	C1QA	0.0021
3816	Complement C1q subcomponent subunit B	C1QB	0.0021
820	Glycine receptor subunit alpha-2	GLRA2	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0021
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0021
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0021
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0021
400	Coagulation factor IX	F9	0.0021
5461	Coagulation factor IX	F9	0.0021
719	Retinoic acid receptor responder protein 1	RARRES1	0.002
770	Retinoic acid-induced protein 3	GPRC5A	0.002
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
1058	Cell division protein kinase 5	CDK5	0.002
1243	Cathepsin D	CTSD	0.0019
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0019
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0019
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0019
604	Vitamin K-dependent protein Z	PROZ	0.0019
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
569	Retinal dehydrogenase 2	ALDH1A2	0.0018
6122	Carbonic anhydrase 3	CA3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
422	Vitamin K-dependent protein C	PROC	0.0017
1245	Vitamin K-dependent protein S	PROS1	0.0017
611	Retinal dehydrogenase 1	ALDH1A1	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
3233	Bile acid receptor	NR1H4	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
2408	Tyrosine-protein kinase SYK	SYK	0.0015
6755	Poliovirus receptor	PVR	0.0015
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
1992	Vitamin D-binding protein	GC	0.0015
340	Apoptotic protease-activating factor 1	APAF1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1152	Glycogen phosphorylase, muscle form	PYGM	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
798	Osteocalcin	BGLAP	0.0014
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
369	Coagulation factor VII	F7	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
85	Growth hormone receptor	GHR	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
292	Activin receptor type-1	ACVR1	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0012
1268	Neuropeptide S receptor	NPSR1	0.0012
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
4943	Cytochrome c6	petJ	0.0012
4954	Soluble cytochrome b558	Not Available	0.0012
4905	Cytochrome c2	Not Available	0.0012
4939	Cytochrome c2	cycA	0.0012
4964	Cytochrome c2	cycA	0.0012
4979	Cytochrome c2	cycA	0.0012
6673	Cytochrome c2	cycA	0.0012
4925	Cytochrome c-type protein SHP	shp	0.0012
4934	Cytochrome c-551	nirM	0.0012
5218	Cytochrome c-551	nirM	0.0012
4947	Bacterial hemoglobin	vhb	0.0012
4984	Neuroglobin	NGB	0.0012
4994	Hemoglobin-like protein HbO	glbO	0.0012
4916	Cyanoglobin	glbN	0.0012
4915	Cytochrome c-550	psbV	0.0012
4959	Cytochrome c-550	psbV	0.0012
5216	Cytochrome c-550	psbV	0.0012
4942	Diheme cytochrome c napB	napB	0.0012
4936	Cytochrome c2 iso-2	Not Available	0.0012
4998	Hemoglobin-like protein yjbI	yjbI	0.0012
4975	Cytochrome c-556	RPA3973	0.0012
4961	Hemophore HasA	hasA	0.0012
4904	Cytochrome c family protein	GSU1996	0.0012
4910	Cytoglobin	CYGB	0.0012
644	Heme oxygenase 2	HMOX2	0.0012
4982	Heme oxygenase 2	pbsA2	0.0012
4909	CooA protein	cooA	0.0012
4981	Iron-starvation protein PigA	pigA	0.0012
5000	HemO	hemO	0.0012
4976	Apocytochrome f	petA	0.0012
6407	Apocytochrome f	petA	0.0012
4907	Cytochrome c-L	moxG	0.0012
6865	Cytochrome c-L	moxG	0.0012
4971	Nonaheme cytochrome c	hmcA	0.0012
4989	Cytochrome c551 peroxidase	ccp	0.0012
5222	Cytochrome c551 peroxidase	ccpA	0.0012
4764	Cytochrome P450 165C4	CYP165C4	0.0012
4937	Cytochrome oxidase subunit II	rcoxA	0.0012
4935	Cytochrome c-554	cycA1	0.0012
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0012
4999	Cytochrome P450 165B3	CYP165B3	0.0012
4960	Putative cytochrome P450-family protein	SCO7417	0.0012
4931	Cytochrome P450 167A1	CYP167A1	0.0012
4972	P450cin	cinA	0.0012
4993	Hydroxylamine oxidoreductase	hao1	0.0012
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0012
4952	Catalase/peroxidase	katA	0.0012
6151	Monocarboxylate transporter 10	SLC16A10	0.0012
4922	Cytochrome c, putative	SO_4144	0.0012
4903	Methyl-accepting chemotaxis protein	Tar4	0.0012
3093	Catalase HPII	katE	0.0012
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0012
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
6073	Potassium channel subfamily K member 9	KCNK9	0.0011
6072	Potassium channel subfamily K member 3	KCNK3	0.0011
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
3007	Carbonic anhydrase 12	CA12	0.001
4205	Carbonic anhydrase 9	CA9	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
740	Argininosuccinate synthase	ASS1	0.001
865	Argininosuccinate synthase	ASS1	0.001
2680	Argininosuccinate synthase	argG	0.001
3194	Argininosuccinate synthase	argG	0.001
6021	Adenosine kinase	ADK	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
4920	Peroxidase/catalase	katG	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
4948	Cytochrome c-553	Not Available	0.0009
4923	Cytochrome c3	DvMF_2499	0.0009
4945	Cytochrome c3	Not Available	0.0009
4949	Cytochrome c3	DVU_3171	0.0009
4968	Cytochrome c3	cytc3	0.0009
4997	Cytochrome c3	SO_2727	0.0009
5219	Cytochrome c3	cyd	0.0009
2119	Cytochrome b5	CYB5A	0.0009
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0009
3189	High-molecular-weight cytochrome c	hmcA	0.0009
4902	Nine-heme cytochrome c	Ddes_2038	0.0009
4990	PpcA	ppcA	0.0009
4289	Cytochrome P450	TT_P0059	0.0009
6262	Cytochrome P450	staP	0.0009
3570	Cytochrome P450 152A1	cypC	0.0009
4988	Sulfite oxidase, mitochondrial	SUOX	0.0009
4992	Cytochrome c peroxidase	Not Available	0.0009
2915	Sensor protein fixL	fixL	0.0009
4944	Sensor protein fixL	fixL	0.0009
3375	Acidic cytochrome c3	Not Available	0.0009
4385	Cytochrome c'	Not Available	0.0009
4967	Cytochrome c'	cycA	0.0009
5038	Cytochrome c'	Not Available	0.0009
5223	Cytochrome c'	cycP	0.0009
4813	Heme oxygenase	hmuO	0.0009
5769	Heme oxygenase	Not Available	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
1184	Interferon beta	IFNB1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3830	Calreticulin	CALR	0.0008
1867	Major prion protein	PRNP	0.0008
6034	Hydroxyindole O-methyltransferase	ASMT	0.0008
6035	Nuclear receptor ROR-beta	RORB	0.0008
6036	Eosinophil peroxidase	EPX	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
3670	Soluble cytochrome b562 precursor	cybC	0.0008
3411	Cytochrome P450 121	cyp121	0.0008
1025	Aquaporin-1	AQP1	0.0008
2617	Nitric oxide synthase oxygenase	nos	0.0008
2701	Nitric oxide synthase oxygenase	nos	0.0008
3291	Cytochrome c-552	cycA	0.0008
4927	Cytochrome c-552	nrfA	0.0008
4938	Cytochrome c-552	cycA	0.0008
4953	Cytochrome c-552	nrfA	0.0008
5217	Cytochrome c-552	cycM	0.0008
4386	Hemoglobin-like protein HbN	glbN	0.0008
3102	Flavohemoprotein	hmp	0.0008
4969	Flavohemoprotein	hmp	0.0008
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
3127	Nitrite reductase	nirS	0.0007
3284	Nitrite reductase	nirS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
693	Hemoglobin subunit beta	HBB	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
6268	Hydroxyacid oxidase 1	HAO1	0.0005
2430	Chondroitinase B	cslB	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
595	Fibrinogen alpha chain	FGA	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
3689	Endoglucanase A	celA	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
2427	Ferrichrome-iron receptor	fhuA	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00773 - Etoposide

Targets

Enzymes

Transporters

Predictions