DT-Web: DB00695

Identification

Name

Furosemide

Accession Number

DB00695 (APRD00608, DB07799)

Type

small molecule

Description

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

330.744

Groups

approved

Monoisotopic Weight

330.007719869

Pharmacology

Indication

For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.

Mechanism of action

Furosemide, a loop diuretic, inhibits water reabsorption in the nephron by blocking the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle. This is achieved through competitive inhibition at the chloride binding site on the cotransporter, thus preventing the transport of sodium from the lumen of the loop of Henle into the basolateral interstitium. Consequently, the lumen becomes more hypertonic while the interstitium becomes less hypertonic, which in turn diminishes the osmotic gradient for water reabsorption throughout the nephron. Because the thick ascending limb is responsible for 25% of sodium reabsorption in the nephron, furosemide is a very potent diuretic.

Absorption

60% absorbed in patients with normal renal function

Protein binding

95% bound to plasma proteins

Biotransformation

Only a small amount is hepatically metabolized to the defurfurylated derivative, 4-chloro-5-sulfamoylanthranilic acid.

Route of elimination

Furosemide is excreted in urine. Significantly more furosemide is excreted in urine following the I.V. injection than after the tablet or oral solution.

Toxicity

Profound diuresis may cause fluid and electrolyte depletion. Excessive dehydration and potassium depletion may occur. Excessive diuresis may cause rapid weight loss, orthostatic hypotension or acute hypotensive episodes. May also cause tinnitus, reversible or permanent hearing loss or reversible deafness.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amikacin	Increased ototoxicity
Cisplatin	Increased ototoxicity
Colesevelam	Bile acid sequestrants such as colesevelam may decrease the absorption of loop diuretics such as furosemide. Monitor for decreased serum concentrations/therapeutic effects of loop diuretics if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Deslanoside	Possible electrolyte variations and arrhythmias
Digitoxin	Possible electrolyte variations and arrhythmias
Digoxin	Possible electrolyte variations and arrhythmias
Ethotoin	The hydantoin decreases the effect of furosemide
Fosphenytoin	The hydantoin decreases the effect of furosemide
Gentamicin	Increased ototoxicity
Ginseng	Ginseng decreases the therapeutic effect
Ibuprofen	The NSAID, ibuprofen, may antagonize the diuretic and antihypertensive effects of the loop diuretic, furosemide.
Indacaterol	Concomitant therapy may increase the risk of hypokalemia via intracellular shunting. Monitor for adverse effects and especially for cardiovascular effects associated with hypokalemia.
Indomethacin	The NSAID, indomethacin, may decrease the diuretic and antihypertensive effects of the loop diuretic, furosemide.
Kanamycin	Increased ototoxicity
Mephenytoin	The hydantoin decreases the effect of furosemide
Netilmicin	Increased ototoxicity
Phenytoin	The hydantoin decreases the effect of furosemide
Streptomycin	Increased ototoxicity
Sulindac	The NSAID, sulindac, may decrease the diuretic and antihypertensive effects of the loop diuretic, furosemide.
Tobramycin	Increased ototoxicity
Trandolapril	The loop diuretic, Furosemide, may increase the hypotensive effect of Trandolapril. Furosemide may also increase the nephrotoxicity of Trandolapril.
Treprostinil	Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.

Food Interactions

Increase potassium intake; add a banana or orange juice; unless instructed otherwise.
Take with food to reduce irritation.
Avoid alcohol.
Avoid excess salt/sodium unless otherwise instructed by your physician.

Solute carrier family 12 member 1
Name	Solute carrier family 12 member 1
Gene Name	SLC12A1
Pharmacological action	yes
Actions	inhibitor
References	Brater DC: Pharmacology of diuretics. Am J Med Sci. 2000 Jan;319(1):38-50. - Pubmed Davies DL, Wilson GM: Diuretics: mechanism of action and clinical application. Drugs. 1975;9(3):178-226. - Pubmed Vormfelde SV, Sehrt D, Toliat MR, Schirmer M, Meineke I, Tzvetkov M, Nurnberg P, Brockmoller J: Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs. Clin Pharmacol Ther. 2007 Sep;82(3):300-9. Epub 2007 Apr 25. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.5597
Carbonic anhydrase 2
Name	Carbonic anhydrase 2
Gene Name	CA2
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	1.4563

6-phosphogluconate dehydrogenase, decarboxylating
Name	6-phosphogluconate dehydrogenase, decarboxylating
Gene Name	PGD
Actions	inhibitor
References	Akkemik E, Budak H, Ciftci M: Effects of some drugs on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro study. J Enzyme Inhib Med Chem. 2010 Mar 17. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.5384

Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor,inducer
References	Kim GH, Na KY, Kim SY, Joo KW, Oh YK, Chae SW, Endou H, Han JS: Up-regulation of organic anion transporter 1 protein is induced by chronic furosemide or hydrochlorothiazide infusion in rat kidney. Nephrol Dial Transplant. 2003 Aug;18(8):1505-11. - Pubmed Hosoyamada M, Sekine T, Kanai Y, Endou H: Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol. 1999 Jan;276(1 Pt 2):F122-8. - Pubmed Lu R, Chan BS, Schuster VL: Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol. 1999 Feb;276(2 Pt 2):F295-303. - Pubmed Uwai Y, Saito H, Hashimoto Y, Inui KI: Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J Pharmacol Exp Ther. 2000 Oct;295(1):261-5. - Pubmed
DTHybrid score	0.5009
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions	inhibitor
References	Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score	0.2691
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	inhibitor
References	Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed
DTHybrid score	0.3913
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	inhibitor
References	Bakos E, Evers R, Sinko E, Varadi A, Borst P, Sarkadi B: Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8. - Pubmed
DTHybrid score	0.2194
Solute carrier organic anion transporter family member 2A1
Name	Solute carrier organic anion transporter family member 2A1
Gene Name	SLCO2A1
Actions	inhibitor
References	Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW, Schuster VL: Identification and characterization of a prostaglandin transporter. Science. 1995 May 12;268(5212):866-9. - Pubmed
DTHybrid score	0.2745
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions	inhibitor
References	Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem. 2000 Feb 11;275(6):4507-12. - Pubmed
DTHybrid score	0.3083

Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions
References	Not Available
DTHybrid score	0.5009
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions
References	Not Available
DTHybrid score	0.2691
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions
References	Not Available
DTHybrid score	0.3913
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions
References	Not Available
DTHybrid score	0.2194
Solute carrier organic anion transporter family member 2A1
Name	Solute carrier organic anion transporter family member 2A1
Gene Name	SLCO2A1
Actions
References	Not Available
DTHybrid score	0.2745
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions
References	Not Available
DTHybrid score	0.3083

Id	Partner name	Gene Name	Score
295	Carbonic anhydrase 1	CA1	0.1617
6143	Solute carrier family 22 member 7	SLC22A7	0.1589
4512	Cytochrome P450 3A4	CYP3A4	0.1434
4757	Cytochrome P450 2C9	CYP2C9	0.1372
1588	Multidrug resistance protein 1	ABCB1	0.1271
592	Carbonic anhydrase 4	CA4	0.1113
20	Prostaglandin G/H synthase 1	PTGS1	0.1092
2164	Multidrug resistance-associated protein 4	ABCC4	0.105
4924	Cytochrome P450 2C8	CYP2C8	0.0999
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0946
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0944
290	Prostaglandin G/H synthase 2	PTGS2	0.0925
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0894
4200	Cytochrome P450 1A2	CYP1A2	0.088
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0867
6016	Cytochrome P450 2C19	CYP2C19	0.0841
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0818
2206	Glucose-6-phosphate isomerase	GPI	0.081
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0802
6144	Solute carrier family 22 member 2	SLC22A2	0.0793
6145	Solute carrier family 22 member 1	SLC22A1	0.0781
862	Multidrug resistance-associated protein 1	ABCC1	0.0766
310	Solute carrier family 12 member 2	SLC12A2	0.0744
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0704
833	Organic cation/carnitine transporter 1	SLC22A4	0.0696
4119	Cytochrome P450 2D6	CYP2D6	0.0655
738	Monocarboxylate transporter 1	SLC16A1	0.0629
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0627
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0578
2621	Thermoresistant gluconokinase	gntK	0.0571
4118	Cytochrome P450 3A5	CYP3A5	0.0556
52	Pyruvate kinase isozymes R/L	PKLR	0.0518
776	Bile salt export pump	ABCB11	0.0513
2922	Glycerol kinase	glpK	0.0504
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0493
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0481
466	Solute carrier family 12 member 3	SLC12A3	0.0479
6024	Cytochrome P450 1A1	CYP1A1	0.0466
6013	Cytochrome P450 2E1	CYP2E1	0.0446
766	Beta-2 adrenergic receptor	ADRB2	0.0445
53	Solute carrier family 12 member 5	SLC12A5	0.0429
663	Solute carrier family 12 member 4	SLC12A4	0.0428
6141	Sodium/bile acid cotransporter	SLC10A1	0.0427
404	DNA gyrase subunit A	gyrA	0.0426
6224	DNA gyrase subunit A	gyrA	0.0426
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0425
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0425
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0425
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0425
6136	Multidrug resistance-associated protein 5	ABCC5	0.042
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0419
6147	Solute carrier family 22 member 3	SLC22A3	0.0409
633	Penicillin-binding proteins 1A/1B	pbpA	0.0405
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0403
6107	Cytochrome P450 3A7	CYP3A7	0.0393
645	Penicillin-binding protein 1A	mrcA	0.0386
5805	Penicillin-binding protein 1A	ponA	0.0386
6185	Penicillin-binding protein 1A	mrcA	0.0386
6799	Penicillin-binding protein 1A	pbpA	0.0386
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0376
4628	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	gapN	0.0375
6030	Cytochrome P450 2B6	CYP2B6	0.0373
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0365
22	30S ribosomal protein S4	rpsD	0.0357
6714	30S ribosomal protein S4	rpsD	0.0357
477	DNA topoisomerase 4 subunit A	parC	0.0355
886	DNA topoisomerase 4 subunit A	parC	0.0355
6226	DNA topoisomerase 4 subunit A	parC	0.0355
1405	Thiopurine S-methyltransferase	TPMT	0.0354
790	DNA polymerase subunit alpha B	POLA2	0.0348
140	30S ribosomal protein S9	rpsI	0.0336
6719	30S ribosomal protein S9	rpsI	0.0336
6725	30S ribosomal protein S9	rpsI	0.0336
527	Prostacyclin receptor	PTGIR	0.0335
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0331
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0324
543	Penicillin-binding protein 1B	mrcB	0.0321
6186	Penicillin-binding protein 1B	ponB	0.0321
6822	Penicillin-binding protein 1b	pbp1b	0.0321
6844	Penicillin-binding protein 1b	pbp1b	0.0321
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.032
3007	Carbonic anhydrase 12	CA12	0.032
4205	Carbonic anhydrase 9	CA9	0.032
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0308
6085	Fatty acid-binding protein, intestinal	FABP2	0.0284
817	DNA topoisomerase 2-alpha	TOP2A	0.0283
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0283
1	Peptidoglycan synthetase ftsI	ftsI	0.0283
4155	Peptidoglycan synthetase ftsI	ftsI	0.0283
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0279
2853	14 kDa fatty acid-binding protein	Not Available	0.0272
6148	Multidrug resistance-associated protein 7	ABCC10	0.0272
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.027
3932	Glutathione S-transferase A2	GSTA2	0.0269
489	Monocarboxylate transporter 2	SLC16A7	0.026
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0258
6126	Carbonic anhydrase 7	CA7	0.0257
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0257
438	Taste receptor type 1 member 2	TAS1R2	0.0248
304	Solute carrier family 12 member 7	SLC12A7	0.0243
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0242
157	Solute carrier family 12 member 6	SLC12A6	0.0242
5718	Cytochrome P450 2A6	CYP2A6	0.0238
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.023
500	Monocarboxylate transporter 4	SLC16A3	0.023
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0228
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0227
3686	Acyl-CoA thioesterase I precursor	tesA	0.0222
672	Prostaglandin F2-alpha receptor	PTGFR	0.0222
6137	Multidrug resistance-associated protein 6	ABCC6	0.0221
332	Beta-lactamase	blaZ	0.0219
2478	Beta-lactamase	ampC	0.0219
2613	Beta-lactamase	ampC	0.0219
2635	Beta-lactamase	ampC	0.0219
2700	Beta-lactamase	penP	0.0219
5445	Beta-lactamase	blaB	0.0219
6019	Beta-lactamase	SHV-7	0.0219
6701	Beta-lactamase	cphA	0.0219
5650	NimA-related protein	DR_0842	0.0218
338	DNA polymerase	UL30	0.0216
379	DNA polymerase	UL54	0.0216
697	DNA polymerase	ORF28	0.0216
2482	DNA polymerase	43	0.0216
4104	DNA polymerase	BALF5	0.0216
3676	Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive	aroG	0.0216
3134	Phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	0.0215
492	Histamine H1 receptor	HRH1	0.0211
6149	Solute carrier family 22 member 10	SLC22A10	0.021
6106	Cytochrome P450 2C18	CYP2C18	0.0209
891	Dihydropteroate synthase	folP	0.0207
5359	Dihydropteroate synthase	folP	0.0207
7175	Dihydropteroate synthase	sulI	0.0207
3623	Divalent-cation tolerance protein cutA	cutA	0.0206
5294	Nucleoside diphosphate kinase A	NME1	0.0204
70	Type-1 angiotensin II receptor	AGTR1	0.0204
887	DNA gyrase subunit B	gyrB	0.0201
4150	DNA gyrase subunit B	gyrB	0.0201
6225	DNA gyrase subunit B	gyrB	0.0201
4384	Capsule biosynthesis protein	synC	0.0199
2016	Dipeptidase 1	DPEP1	0.0197
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0196
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0196
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0196
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0195
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0192
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0192
6151	Monocarboxylate transporter 10	SLC16A10	0.0191
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0188
1116	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	PCK1	0.0188
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0187
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0185
5353	Glutamate decarboxylase alpha	gadA	0.0183
6167	Organic solute transporter subunit beta	OSTB	0.0178
6166	Organic solute transporter subunit alpha	OSTA	0.0178
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0176
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0175
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0175
5626	Nucleoside diphosphate kinase B	NME2	0.0175
275	Arachidonate 5-lipoxygenase	ALOX5	0.0173
4604	Liver carboxylesterase 1	CES1	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
1867	Major prion protein	PRNP	0.0163
2310	2-dehydro-3-deoxyphosphooctonate aldolase	kdsA	0.0163
2542	2-dehydro-3-deoxyphosphooctonate aldolase	kdsA	0.0163
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.0163
136	Estrogen receptor	ESR1	0.0162
1898	Cytochrome P450 1B1	CYP1B1	0.0161
1792	Tissue-type plasminogen activator	PLAT	0.0161
24	Thymidylate synthase	TMP1	0.0158
359	Thymidylate synthase	TYMS	0.0158
2626	Thymidylate synthase	thyA	0.0158
2729	Thymidylate synthase	thyA	0.0158
5352	Thymidylate synthase	THYA	0.0158
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
3426	Glutamine synthetase	glnA	0.0151
3987	Glutamine synthetase	GLUL	0.0151
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.015
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
6020	Aldehyde oxidase	AOX1	0.0149
1757	Myeloperoxidase	MPO	0.0148
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0141
6209	30S ribosomal protein S19	rpsS	0.0141
6712	30S ribosomal protein S19	rpsS	0.0141
6726	30S ribosomal protein S19	rpsS	0.0141
6207	30S ribosomal protein S14	rpsN	0.0141
124	Histamine H2 receptor	HRH2	0.0141
3947	Xanthine dehydrogenase/oxidase	XDH	0.0139
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0139
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0139
3811	Cytochrome P450 19A1	CYP19A1	0.0138
3226	UPF0234 protein HI1034	HI_1034	0.0135
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0134
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0134
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0133
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0133
1650	Heme carrier protein 1	SLC46A1	0.0132
3384	Macrophage migration inhibitory factor	MIF	0.0132
373	Transthyretin	TTR	0.0128
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0127
183	Vascular endothelial growth factor A	VEGFA	0.0125
130	Prostacyclin synthase	PTGIS	0.0124
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0123
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0123
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
6033	High affinity interleukin-8 receptor A	CXCR1	0.0122
293	Gamma-glutamyl hydrolase	GGH	0.0122
1198	Serum paraoxonase/arylesterase 1	PON1	0.012
6223	Penicillin-binding protein 1C	pbpC	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
5818	Folate receptor alpha	FOLR1	0.0119
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0115
756	Sex hormone-binding globulin	SHBG	0.0115
6131	Carbonic anhydrase 14	CA14	0.0114
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0113
2249	Aspartate aminotransferase	aspC	0.0112
2671	Aspartate aminotransferase	aspC	0.0112
5490	Aspartate aminotransferase	Not Available	0.0112
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0112
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0112
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0112
3639	Thymidine phosphorylase	deoA	0.0111
3936	Thymidine phosphorylase	TYMP	0.0111
4790	Glycosyltransferase GtfA	gtfA	0.011
2320	Thymidine kinase, cytosolic	TK1	0.011
6122	Carbonic anhydrase 3	CA3	0.0109
3105	M-phase inducer phosphatase 2	CDC25B	0.0108
2443	Azurin	azu	0.0108
2757	Inorganic pyrophosphatase	ppa	0.0107
6238	Inorganic pyrophosphatase	ppa	0.0107
6968	Inorganic pyrophosphatase	PPA1	0.0107
2383	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
2937	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
4620	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
6594	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
6609	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
6646	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
146	Androgen receptor	AR	0.0101
65	Matrix metalloproteinase-9	Not Available	0.0101
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0101
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0101
624	Guanidinoacetate N-methyltransferase	GAMT	0.01
115	Penicillin-binding protein 2	mrdA	0.0099
6069	Penicillin-binding protein 2	mrdA	0.0099
6118	Penicillin-binding protein 2	penA	0.0099
6187	Penicillin-binding protein 2	pbpA	0.0099
6686	Penicillin-binding protein 2	pbp2	0.0099
6939	Penicillin-binding protein 2	mrdA	0.0099
7163	Penicillin-binding protein 2	pbpA	0.0099
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0099
3760	Penicillin-binding protein 5 precursor	dacA	0.0098
2211	Fatty acid-binding protein, heart	FABP3	0.0098
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0098
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0097
6067	Penicillin binding protein 2a	mecA	0.0096
819	Penicillin-binding protein 4	dacB	0.0096
2755	Hypoxanthine-guanine-xanthine phosphoribosyltransferase	LACZ	0.0095
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0094
566	Serotransferrin	TF	0.0094
4553	Bifunctional adenosylcobalamin biosynthesis protein cobU	cobU	0.0094
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0094
867	Penicillin-binding protein 3	pbpC	0.0094
6119	Penicillin-binding protein 3	pbp3	0.0094
7154	Penicillin-binding protein 3	pbp3	0.0094
7157	Penicillin-binding protein 3	LMHCC_2184	0.0094
7162	Penicillin-binding protein 3	pbpB	0.0094
7172	Penicillin-binding protein 3	pbp3	0.0094
2647	RNA-directed RNA polymerase	P2	0.0094
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0093
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0093
6043	Putative G-protein coupled receptor 44	GPR44	0.0093
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0093
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
199	Monocarboxylate transporter 8	SLC16A2	0.0093
1654	Interleukin-1 beta	IL1B	0.0092
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0091
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.009
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.009
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.009
131	Synaptic vesicular amine transporter	SLC18A2	0.009
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0089
6010	Thiamine transporter 1	SLC19A2	0.0089
218	Monocarboxylate transporter 5	SLC16A4	0.0088
195	Monocarboxylate transporter 7	SLC16A6	0.0088
397	Monocarboxylate transporter 3	SLC16A8	0.0088
429	Monocarboxylate transporter 6	SLC16A5	0.0088
3010	Regulatory protein blaR1	blaR1	0.0087
2149	Angiogenin	ANG	0.0087
380	Cytochrome P450 17A1	CYP17A1	0.0086
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0086
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0086
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0086
2727	S-adenosylmethionine synthetase	metK	0.0084
6218	Pannexin-1	PANX1	0.0084
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0084
723	Cytosolic phospholipase A2	PLA2G4A	0.0083
2472	Voltage-gated potassium channel	kcsA	0.0083
6366	Voltage-gated potassium channel	kcsA	0.0083
2885	Carboxyethyl-arginine beta-lactam-synthase	bls	0.0082
4600	Malonamidase E2	Not Available	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
175	Thiamin pyrophosphokinase 1	TPK1	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0079
2808	Chloramphenicol acetyltransferase 3	cat3	0.0079
2717	Folylpolyglutamate synthase	fgs	0.0079
614	Progesterone receptor	PGR	0.0079
4217	Telomerase reverse transcriptase	TERT	0.0078
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0078
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0078
244	Angiotensin-converting enzyme	ACE	0.0076
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0076
771	Pyruvate carboxylase, mitochondrial	PC	0.0076
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0076
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0075
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0075
494	Caspase-1	CASP1	0.0075
556	Alpha-1A adrenergic receptor	ADRA1A	0.0075
3941	Amine oxidase [flavin-containing] A	MAOA	0.0075
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0074
6395	Myosin-14	MYH14	0.0074
2428	Thiamine-phosphate pyrophosphorylase	thiE	0.0074
98	Pyruvate kinase isozymes M1/M2	PKM2	0.0074
629	Alpha-2B adrenergic receptor	ADRA2B	0.0073
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0073
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0073
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0073
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0073
1636	Trace amine-associated receptor 1	TAAR1	0.0073
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0073
1507	Cytochrome c	CYCS	0.0072
273	Apoptosis regulator Bcl-2	BCL2	0.0072
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0071
185	Vasopressin V1a receptor	AVPR1A	0.0071
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
3923	Cholinesterase	BCHE	0.0071
23	D(1A) dopamine receptor	DRD1	0.0071
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0071
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.007
322	Vasopressin V2 receptor	AVPR2	0.007
468	Cytochrome P450 4A11	CYP4A11	0.0069
632	Alpha-1B adrenergic receptor	ADRA1B	0.0069
737	Mineralocorticoid receptor	NR3C2	0.0069
318	Alpha-2A adrenergic receptor	ADRA2A	0.0069
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0068
3627	UPF0190 protein yedY	yedY	0.0067
1392	Catenin beta-1	CTNNB1	0.0067
3352	Structural polyprotein	Not Available	0.0067
3628	Structural polyprotein	Not Available	0.0067
4892	Structural polyprotein	Not Available	0.0067
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0067
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0067
594	Thyroxine-binding globulin	SERPINA7	0.0066
831	D(2) dopamine receptor	DRD2	0.0066
36	Insulin receptor	INSR	0.0066
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0066
2021	Thrombomodulin	THBD	0.0065
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0065
365	Dihydrofolate reductase	DHFR	0.0065
2381	Dihydrofolate reductase	DFR1	0.0065
2833	Dihydrofolate reductase	Not Available	0.0065
2931	Dihydrofolate reductase	folA	0.0065
3544	Dihydrofolate reductase	folA	0.0065
3682	Dihydrofolate reductase	folA	0.0065
6642	Dihydrofolate reductase	folA	0.0065
6756	Dihydrofolate reductase	dfrA	0.0065
3685	Catabolite gene activator	crp	0.0065
4655	Adenylate cyclase	cyaC	0.0064
4759	Adenylate cyclase	cyaB2	0.0064
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0064
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0063
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0063
192	Creatine kinase, ubiquitous mitochondrial	CKMT1A	0.0063
456	Creatine kinase, sarcomeric mitochondrial	CKMT2	0.0063
92	Creatine kinase B-type	CKB	0.0063
414	Sodium- and chloride-dependent creatine transporter 1	SLC6A8	0.0063
5126	Arginase	rocF	0.0063
2077	Caspase-3	CASP3	0.0063
474	Acetylcholinesterase	ACHE	0.0063
3270	Elongation factor G	fusA	0.0062
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0061
844	Epidermal growth factor receptor	EGFR	0.0061
758	Thyroid hormone receptor alpha	THRA	0.0061
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0061
705	Glutamate receptor 1	GRIA1	0.0061
482	Glycine receptor subunit alpha-1	GLRA1	0.006
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.006
509	Thymidine kinase	TK	0.006
570	Thymidine kinase	TK	0.006
2559	Thymidine kinase	TK	0.006
3430	Thymidine kinase	tdk	0.006
3518	Thymidine kinase	TK	0.006
5301	Thymidine kinase	tdk	0.006
5771	Thymidine kinase	ORF36	0.006
7009	Thymidine kinase	ORF36	0.006
6168	Solute carrier family 22 member 16	SLC22A16	0.006
908	Glutathione S-transferase theta-1	GSTT1	0.006
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0059
1025	Aquaporin-1	AQP1	0.0059
6042	Prostaglandin reductase 2	PTGR2	0.0059
713	Sodium-dependent dopamine transporter	SLC6A3	0.0059
824	Sodium-dependent serotonin transporter	SLC6A4	0.0059
1714	Mitogen-activated protein kinase 3	MAPK3	0.0058
378	Alpha-2C adrenergic receptor	ADRA2C	0.0058
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0057
904	Glutathione S-transferase P	GSTP1	0.0057
788	Creatine kinase M-type	CKM	0.0057
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0057
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0057
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0056
33	Cystine/glutamate transporter	SLC7A11	0.0056
4760	Mll3241 protein	mll3241	0.0055
346	Thyroid hormone receptor beta-1	THRB	0.0055
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0054
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0054
4252	Penicillin-binding protein 5	dacA	0.0053
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0052
159	Penicillin-binding protein 2B	penA	0.0052
6121	Penicillin-binding protein 2B	penA	0.0052
860	Nicotinamide N-methyltransferase	NNMT	0.0051
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0051
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0051
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0051
699	Nicotinic acid receptor 1	GPR109A	0.0051
928	Nicotinic acid receptor 2	GPR109B	0.0051
3810	Catechol O-methyltransferase	COMT	0.0051
1313	Lactoylglutathione lyase	GLO1	0.0051
997	Protein kinase C beta type	PRKCB	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
1141	Sialidase-1	NEU1	0.0049
64	Neuraminidase	NA	0.0049
641	Neuraminidase	NA	0.0049
2676	Neuraminidase	NA	0.0049
3026	Neuraminidase	NA	0.0049
3519	Neuraminidase	NA	0.0049
6007	Neuraminidase	NA	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0049
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0048
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0048
3587	Gastrotropin	FABP6	0.0048
731	HIV-1 protease	HIV-1 protease	0.0048
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0048
551	Carnitine O-acetyltransferase	CRAT	0.0047
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0046
6014	Cytochrome P450 2A13	CYP2A13	0.0046
2408	Tyrosine-protein kinase SYK	SYK	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
707	72 kDa type IV collagenase	MMP2	0.0046
1970	Protein kinase C alpha type	PRKCA	0.0046
6163	Copper-transporting ATPase 2	ATP7B	0.0046
6165	Copper-transporting ATPase 1	ATP7A	0.0046
459	Retinoic acid receptor RXR-alpha	RXRA	0.0046
789	Alpha-1D adrenergic receptor	ADRA1D	0.0045
634	Squalene monooxygenase	SQLE	0.0045
7196	Squalene monooxygenase	ERG1	0.0045
6031	Cytochrome P450 3A43	CYP3A43	0.0045
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0044
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0044
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0044
869	Estrogen receptor beta	ESR2	0.0044
6146	High affinity copper uptake protein 1	SLC31A1	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0043
3939	Amine oxidase [flavin-containing] B	MAOB	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0042
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0042
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0042
896	Glutathione S-transferase Mu 1	GSTM1	0.0042
751	Potassium channel subfamily K member 6	KCNK6	0.0042
1629	Transcription factor AP-1	JUN	0.0041
193	Beta-1 adrenergic receptor	ADRB1	0.0041
408	Riboflavin kinase	RFK	0.0041
5682	Ribonuclease pancreatic	RNASE1	0.0041
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
315	Arginase-1	ARG1	0.004
1039	Histone deacetylase 9	HDAC9	0.004
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.004
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0039
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0039
4773	Deoxycytidine kinase	DCK	0.0039
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0039
828	Phenylalanine-4-hydroxylase	PAH	0.0039
3109	Phenylalanine-4-hydroxylase	phhA	0.0039
5482	Sialidase-2	NEU2	0.0039
172	Potassium channel subfamily K member 1	KCNK1	0.0038
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0038
2232	Interleukin-5	IL5	0.0037
1593	Mucin-2	MUC2	0.0037
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0037
2300	Lysozyme	E	0.0037
3633	Lysozyme	R	0.0037
5597	Lysozyme	17	0.0037
1517	Beta-3 adrenergic receptor	ADRB3	0.0037
6501	Fatty acid-binding protein, liver	FABP1	0.0036
952	Dipeptidyl peptidase 4	DPP4	0.0036
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0036
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0036
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0036
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0035
2236	Casein kinase II subunit alpha	CSNK2A1	0.0035
740	Argininosuccinate synthase	ASS1	0.0035
865	Argininosuccinate synthase	ASS1	0.0035
2680	Argininosuccinate synthase	argG	0.0035
3194	Argininosuccinate synthase	argG	0.0035
461	Glycine receptor subunit alpha-3	GLRA3	0.0035
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0035
161	Tubulin beta chain	TUBB	0.0034
312	Tubulin beta chain	TUB2	0.0034
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0034
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0034
1341	Histamine H3 receptor	HRH3	0.0034
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0034
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0034
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0034
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0034
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0034
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0034
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0034
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0033
7	Nitric oxide synthase, inducible	NOS2	0.0033
2178	Metabotropic glutamate receptor 5	GRM5	0.0033
5923	Microtubule-associated protein tau	MAPT	0.0033
5924	Microtubule-associated protein 4	MAP4	0.0033
465	Calmodulin	CALM1	0.0033
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0033
499	Arginine decarboxylase	ADC	0.0033
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0032
164	Histamine H4 receptor	HRH4	0.0032
6677	Myelin P2 protein	PMP2	0.0032
6102	Arylamine N-acetyltransferase 2	NAT2	0.0032
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0031
1123	Eosinophil cationic protein	RNASE3	0.0031
504	Mast/stem cell growth factor receptor	KIT	0.0031
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0031
577	Argininosuccinate lyase	ASL	0.0031
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0031
921	Glutamate receptor 2	GRIA2	0.0031
1852	Microtubule-associated protein 2	MAP2	0.0031
834	Arginase-2, mitochondrial	ARG2	0.0031
1050	Bile salt sulfotransferase	SULT2A1	0.003
150	Cationic amino acid transporter 3	SLC7A3	0.003
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.003
58	Cationic amino acid transporter 4	SLC7A4	0.003
26	Vascular endothelial growth factor receptor 3	FLT4	0.003
165	FL cytokine receptor	FLT3	0.0029
654	Flavin reductase	BLVRB	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
32	Vascular endothelial growth factor receptor 1	FLT1	0.0028
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0028
777	Tumor necrosis factor	TNF	0.0028
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0028
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0028
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0028
4192	DNA topoisomerase 2-beta	TOP2B	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
702	UMP-CMP kinase	CMPK1	0.0028
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0027
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0027
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0027
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0027
1569	G1/S-specific cyclin-D1	CCND1	0.0027
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0027
122	P2Y purinoceptor 12	P2RY12	0.0026
29	Tubulin beta-1 chain	TUBB1	0.0026
6171	Solute carrier family 28 member 3	SLC28A3	0.0026
291	Nitric-oxide synthase, endothelial	NOS3	0.0026
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0026
822	Aldose reductase	AKR1B1	0.0026
4203	Histamine N-methyltransferase	HNMT	0.0026
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0026
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0026
976	Platelet glycoprotein IX	GP9	0.0025
1760	Aminopeptidase N	ANPEP	0.0025
6843	Aminopeptidase N	pepN	0.0025
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0025
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0025
847	Mu-type opioid receptor	OPRM1	0.0025
117	Sterol O-acyltransferase 1	SOAT1	0.0025
811	Translocator protein	TSPO	0.0024
6211	Tubulin epsilon chain	TUBE1	0.0024
6210	Tubulin delta chain	TUBD1	0.0024
6212	Tubulin gamma-1 chain	TUBG1	0.0024
6432	Transporter	snf	0.0024
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0024
6231	Pepsin A	PGA3	0.0024
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0024
1353	DNA topoisomerase 1	TOP1	0.0024
3552	DNA topoisomerase 1	topA	0.0024
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0023
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0023
407	Vascular endothelial growth factor receptor 2	KDR	0.0023
696	Kappa-type opioid receptor	OPRK1	0.0023
1525	Heparin-binding growth factor 2	FGF2	0.0022
6103	Arylamine N-acetyltransferase 1	NAT1	0.0022
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0022
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0022
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
2391	Ferrochelatase	hemH	0.0022
6502	Ferrochelatase	DKFZp686P18130	0.0022
1591	Ferrochelatase, mitochondrial	FECH	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
3830	Calreticulin	CALR	0.0022
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0022
1196	Complement decay-accelerating factor	CD55	0.0021
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0021
718	Folate receptor gamma	FOLR3	0.0021
299	Folate receptor beta	FOLR2	0.0021
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0021
1192	Sulfotransferase 1A1	SULT1A1	0.0021
4210	Toll-like receptor 4	TLR4	0.0021
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0021
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
871	Glucocorticoid receptor	NR3C1	0.0021
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.002
4120	NADPH--cytochrome P450 reductase	POR	0.002
768	FK506-binding protein 1A	FKBP1A	0.002
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.002
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.002
769	High-affinity choline transporter 1	SLC5A7	0.002
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.002
861	Choline kinase alpha	CHKA	0.002
700	Choline dehydrogenase, mitochondrial	CHDH	0.002
3927	Choline transporter-like protein 3	SLC44A3	0.002
1686	Choline transporter-like protein 1	SLC44A1	0.002
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.002
3926	Choline transporter-like protein 2	SLC44A2	0.002
3925	Choline transporter-like protein 4	SLC44A4	0.002
576	Choline O-acetyltransferase	CHAT	0.002
3922	Phospholipase D2	PLD2	0.002
3924	Phospholipase D1	PLD1	0.002
274	Muscarinic acetylcholine receptor M5	CHRM5	0.002
1630	Integrin beta-2	ITGB2	0.002
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.002
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.002
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.002
6034	Hydroxyindole O-methyltransferase	ASMT	0.002
6035	Nuclear receptor ROR-beta	RORB	0.002
6036	Eosinophil peroxidase	EPX	0.002
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.002
1992	Vitamin D-binding protein	GC	0.002
2539	Tubulin alpha-1 chain	TUBA4A	0.002
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0019
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0019
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0019
6837	Serine/threonine-protein kinase 17B	STK17B	0.0019
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0019
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0019
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0019
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0019
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0019
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0019
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0019
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0019
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0019
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0019
6559	Cytochrome c oxidase subunit 2	ctaC	0.0019
6669	Cytochrome c oxidase subunit 2	ctaC	0.0019
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0019
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0019
6558	Cytochrome c oxidase subunit 1	ctaD	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5787	Angiopoietin-1 receptor	TEK	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
5934	Cytochrome P450 26A1	CYP26A1	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
153	Dopamine beta-hydroxylase	DBH	0.0018
1176	Mitogen-activated protein kinase 1	MAPK1	0.0018
2449	Tubulin alpha-3 chain	TUBA1A	0.0017
2540	Choloylglycine hydrolase	cbh	0.0017
765	Indoleamine 2,3-dioxygenase	IDO1	0.0017
163	D(1B) dopamine receptor	DRD5	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
1291	cAMP response element-binding protein	CREB1	0.0017
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
780	Retinoic acid receptor RXR-gamma	RXRG	0.0017
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0016
571	Melatonin receptor type 1A	MTNR1A	0.0016
362	Melatonin receptor type 1B	MTNR1B	0.0016
432	D(4) dopamine receptor	DRD4	0.0016
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0016
6044	Serum paraoxonase/lactonase 3	PON3	0.0016
3616	Fatty acid-binding protein, epidermal	FABP5	0.0016
5431	Lipid binding protein	Not Available	0.0016
5433	UPF0230 protein TM_1468	TM_1468	0.0016
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0016
2207	Rhodopsin	RHO	0.0016
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0016
638	D(3) dopamine receptor	DRD3	0.0016
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0016
88	Retinoic acid receptor RXR-beta	RXRB	0.0016
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0016
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
162	Retinoic acid receptor gamma-1	RARG	0.0015
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0015
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0015
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0015
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0015
572	Integrin alpha-L	ITGAL	0.0015
2599	Tyrosine-protein kinase HCK	HCK	0.0015
3809	Estrogen-related receptor gamma	ESRRG	0.0014
2693	Heat-labile enterotoxin B chain	eltB	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0014
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0014
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0014
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0014
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0014
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0014
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
4122	Histone deacetylase 2	HDAC2	0.0014
6500	Phospholipase A2	PLA2G1B	0.0014
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0014
467	Delta-type opioid receptor	OPRD1	0.0013
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
1656	CYP2B protein	CYP2B	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
283	SEC14-like protein 2	SEC14L2	0.0013
1618	High affinity nerve growth factor receptor	NTRK1	0.0013
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0013
6459	Glycodelin	PAEP	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0013
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0013
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0013
76	Nitric-oxide synthase, brain	NOS1	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0012
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0012
517	Alcohol dehydrogenase 1C	ADH1C	0.0012
4226	Uridine phosphorylase 2	UPP2	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0012
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0012
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0012
260	Cytochrome P450 51	ERG11	0.0011
761	Cytochrome P450 51	ERG11	0.0011
3163	Cytochrome P450 51	cyp51	0.0011
6220	Aryl hydrocarbon receptor	AHR	0.0011
4225	Uridine phosphorylase 1	UPP1	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
340	Apoptotic protease-activating factor 1	APAF1	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
84	Nuclear receptor 0B1	NR0B1	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0011
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0011
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0011
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0011
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0011
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.001
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.001
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.001
469	Annexin A1	ANXA1	0.001
413	Amidophosphoribosyltransferase	PPAT	0.001
2515	Amidophosphoribosyltransferase	purF	0.001
3714	Amidophosphoribosyltransferase	purF	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
1275	Estrogen sulfotransferase	SULT1E1	0.001
284	DNA-directed RNA polymerase beta chain	rpoB	0.001
5773	DNA-directed RNA polymerase beta chain	rpoB	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
825	Arsenical pump-driving ATPase	ASNA1	0.001
3435	Arsenical pump-driving ATPase	arsA	0.001
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.001
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.001
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.001
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.001
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.001
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.001
733	Activin receptor type 1B	ACVR1B	0.001
154	AFG3-like protein 2	AFG3L2	0.001
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.001
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.001
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.001
395	ALK tyrosine kinase receptor	Not Available	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
6130	Carbonic anhydrase 13	CA13	0.0009
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0009
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0009
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0009
233	Potassium channel subfamily K member 2	KCNK2	0.0009
1864	RET proto-oncogene	RET	0.0009
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0009
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0009
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0009
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0009
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0009
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0009
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0009
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0009
292	Activin receptor type-1	ACVR1	0.0009
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0009
849	Activated CDC42 kinase 1	TNK2	0.0009
6127	Carbonic anhydrase-related protein	CA8	0.0009
6129	Carbonic anhydrase-related protein 11	CA11	0.0009
6128	Carbonic anhydrase-related protein 10	CA10	0.0009
6135	Sodium channel subunit beta-4	SCN4B	0.0009
6133	Sodium channel subunit beta-2	SCN2B	0.0009
6134	Sodium channel subunit beta-3	SCN3B	0.0009
6132	Sodium channel subunit beta-1	SCN1B	0.0009
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0009
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0009
1268	Neuropeptide S receptor	NPSR1	0.0009
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0009
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0009
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0009
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0009
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0009
297	Adenylate cyclase type 1	ADCY1	0.0009
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0008
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0008
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0008
4527	Putative hydrolase ycdX	ycdX	0.0008
4536	Transcriptional regulator, IclR family	TM_0065	0.0008
2501	Protein ygbM	ygbM	0.0008
4545	Molybdopterin-converting factor subunit 2	moaE	0.0008
4522	Arginine N-succinyltransferase subunit alpha	astA	0.0008
4106	Guanylate kinase	GUK1	0.0008
4516	Guanylate kinase	gmk	0.0008
4538	Hypothetical protein VC1899	VC_1899	0.0008
4529	Oxalate decarboxylase oxdC	oxdC	0.0008
4514	Citrate lyase beta subunit-like protein	citE	0.0008
4781	Citrate lyase beta subunit-like protein	DR_1240	0.0008
4526	Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein	TM_1223	0.0008
4524	Mannose-6-phosphate isomerase	yvyI	0.0008
4535	Glutaconyl-CoA decarboxylase subunit alpha	gcdA	0.0008
4547	Iron binding protein FbpA	fbpA	0.0008
4548	Gyrase B	gyrB	0.0008
4546	Aminotransferase, putative	TM_1131	0.0008
658	Para-aminobenzoate synthase component 1	pabB	0.0008
4515	Peripheral plasma membrane protein CASK	CASK	0.0008
484	Tyrosine-protein kinase ABL2	ABL2	0.0008
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0008
3937	Fatty-acid amide hydrolase	FAAH	0.0008
6073	Potassium channel subfamily K member 9	KCNK9	0.0008
6072	Potassium channel subfamily K member 3	KCNK3	0.0008
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0008
4496	C-terminal-binding protein 1	CTBP1	0.0008
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0007
4034	Glutaredoxin-1	GLRX	0.0007
910	Epididymal secretory glutathione peroxidase	GPX5	0.0007
903	Glutathione S-transferase A5	GSTA5	0.0007
4037	Hypothetical protein	GPX1	0.0007
4297	Hypothetical protein	SP_1951	0.0007
4521	Hypothetical protein	BC_2969	0.0007
4540	Hypothetical protein	TM_1070	0.0007
4555	Hypothetical protein	MT1739	0.0007
4569	Hypothetical protein	mshD	0.0007
4578	Hypothetical protein	PA3270	0.0007
4747	Hypothetical protein	PA3967	0.0007
5177	Hypothetical protein	TM_0096	0.0007
5194	Hypothetical protein	PA1204	0.0007
5240	Hypothetical protein	Rv2991	0.0007
5370	Hypothetical protein	TM_1158	0.0007
5710	Hypothetical protein	Tb927.5.1360	0.0007
1928	Leukotriene C4 synthase	LTC4S	0.0007
4029	Microsomal glutathione S-transferase 3	MGST3	0.0007
4032	Microsomal glutathione S-transferase 1	MGST1	0.0007
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0007
4040	Glutathione peroxidase 7	GPX7	0.0007
907	Glutathione peroxidase 2	GPX2	0.0007
4038	Glutathione peroxidase 4	GPX4	0.0007
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0007
906	Glutathione peroxidase 1	GPX1	0.0007
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0007
4035	Glutathione S-transferase Mu 5	GSTM5	0.0007
4036	Glutathione peroxidase 6	GPX6	0.0007
900	Glutathione S-transferase A4	GSTA4	0.0007
911	Glutathione peroxidase 3	GPX3	0.0007
4042	Glutathione transferase omega-2	GSTO2	0.0007
4033	S-formylglutathione hydrolase	ESD	0.0007
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0007
4517	Probable butyrate kinase 2	buk2	0.0007
3261	Signal recognition particle protein	ffh	0.0007
4528	Phenazine biosynthesis protein PhzD	phzD1	0.0007
4533	Glyoxalase family protein	BC_1747	0.0007
56	Delta-aminolevulinic acid dehydratase	ALAD	0.0007
2356	Delta-aminolevulinic acid dehydratase	hemB	0.0007
3613	Delta-aminolevulinic acid dehydratase	hemB	0.0007
3674	Delta-aminolevulinic acid dehydratase	hemB	0.0007
3759	Glutathione S-transferase	gst	0.0007
4541	Glutathione S-transferase	GST	0.0007
4542	Glutaminase 1	glsA1	0.0007
4544	Glutaminase 1	glsA1	0.0007
2929	(S)-2-haloacid dehalogenase	dhlB	0.0007
2995	(S)-2-haloacid dehalogenase	Not Available	0.0007
3237	Beta-lactamase OXA-2	bla	0.0007
4532	Gephyrin	GPHN	0.0007
6021	Adenosine kinase	ADK	0.0007
661	ADP/ATP translocase 1	SLC25A4	0.0007
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0007
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0007
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0007
898	Glutathione S-transferase A3	GSTA3	0.0007
4531	Putative ketoacyl reductase	actIII	0.0007
2775	Dihydroorotate dehydrogenase	pyrD	0.0007
3467	Methylglyoxal synthase	mgsA	0.0007
897	Glutathione S-transferase kappa 1	GSTK1	0.0007
3583	6-phosphogluconolactonase	pgl	0.0007
909	Maleylacetoacetate isomerase	GSTZ1	0.0007
899	Glutathione S-transferase Mu 3	GSTM3	0.0006
905	Glutathione transferase omega-1	GSTO1	0.0006
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0006
4041	Microsomal glutathione S-transferase 2	MGST2	0.0006
810	Heme oxygenase 1	HMOX1	0.0006
3391	Heme oxygenase 1	pbsA1	0.0006
2525	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0006
3201	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0006
2688	Peptide deformylase	def	0.0006
2708	Peptide deformylase	def	0.0006
3004	Peptide deformylase	def	0.0006
4337	Peptide deformylase	def	0.0006
4338	Peptide deformylase	def	0.0006
5368	Peptide deformylase	def	0.0006
5371	Peptide deformylase	def	0.0006
6375	Peptide deformylase	def	0.0006
6378	Peptide deformylase	def	0.0006
6379	Peptide deformylase	def	0.0006
6776	Peptide deformylase	def	0.0006
6900	Peptide deformylase	def	0.0006
4534	Cytohesin-2	CYTH2	0.0006
2165	Glutathione S-transferase Mu 2	GSTM2	0.0006
2548	Subtilisin Carlsberg	apr	0.0006
207	Glutathione synthetase	GSS	0.0006
5269	Glutathione synthetase	gshB	0.0006
4269	Hypoxanthine-guanine phosphoribosyltransferase, putative	HGPRTase	0.0006
901	Glutathione S-transferase Mu 4	GSTM4	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
4031	Glutathione S-transferase A1	GSTA1	0.0005
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0005
3027	Streptavidin	Not Available	0.0005
714	Glutathione reductase, mitochondrial	GSR	0.0005
5961	Insulin	INS	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
6755	Poliovirus receptor	PVR	0.0005
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0004
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
716	5-hydroxytryptamine 7 receptor	HTR7	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0004
2297	Genome polyprotein	Not Available	0.0004
2322	Genome polyprotein	Not Available	0.0004
2694	Genome polyprotein	Not Available	0.0004
2719	Genome polyprotein	Not Available	0.0004
2860	Genome polyprotein	Not Available	0.0004
2928	Genome polyprotein	Not Available	0.0004
3160	Genome polyprotein	Not Available	0.0004
3260	Genome polyprotein	Not Available	0.0004
4783	Genome polyprotein	Not Available	0.0004
5726	Genome polyprotein	Not Available	0.0004
5779	Genome polyprotein	Not Available	0.0004
5867	Genome polyprotein	Not Available	0.0004
6253	Genome polyprotein	Not Available	0.0004
6301	Genome polyprotein	Not Available	0.0004
6380	Genome polyprotein	Not Available	0.0004
6381	Genome polyprotein	Not Available	0.0004
6437	Genome polyprotein	Not Available	0.0004
6520	Genome polyprotein	Not Available	0.0004
6521	Genome polyprotein	Not Available	0.0004
6652	Genome polyprotein	Not Available	0.0004
6734	Genome polyprotein	Not Available	0.0004
6735	Genome polyprotein	Not Available	0.0004
6736	Genome polyprotein	Not Available	0.0004
6737	Genome polyprotein	Not Available	0.0004
6738	Genome polyprotein	Not Available	0.0004
6739	Genome polyprotein	Not Available	0.0004
6744	Genome polyprotein	Not Available	0.0004
6748	Genome polyprotein	Not Available	0.0004
6894	Genome polyprotein	Not Available	0.0004
6898	Genome polyprotein	Not Available	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0003
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0003
4943	Cytochrome c6	petJ	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
5000	HemO	hemO	0.0003
4916	Cyanoglobin	glbN	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4984	Neuroglobin	NGB	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4961	Hemophore HasA	hasA	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4910	Cytoglobin	CYGB	0.0003
3116	Bacterioferritin	bfr	0.0003
4906	Bacterioferritin	bfr	0.0003
4965	Bacterioferritin	bfr	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4909	CooA protein	cooA	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4952	Catalase/peroxidase	katA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
6228	Nuclear receptor coactivator 1	NCOA1	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
4920	Peroxidase/catalase	katG	0.0002
4923	Cytochrome c3	DvMF_2499	0.0002
4945	Cytochrome c3	Not Available	0.0002
4949	Cytochrome c3	DVU_3171	0.0002
4968	Cytochrome c3	cytc3	0.0002
4997	Cytochrome c3	SO_2727	0.0002
5219	Cytochrome c3	cyd	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4948	Cytochrome c-553	Not Available	0.0002
4902	Nine-heme cytochrome c	Ddes_2038	0.0002
3189	High-molecular-weight cytochrome c	hmcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
4990	PpcA	ppcA	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
4386	Hemoglobin-like protein HbN	glbN	0.0002
518	Peroxidase/catalase T	katG	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
3221	Cytochrome c4	cc4	0.0002
605	Fumarate reductase flavoprotein subunit	frdA	0.0002
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0002
3673	Fumarate reductase flavoprotein subunit	fccA	0.0002
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0002
6549	Fumarate reductase flavoprotein subunit	frdA	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
2298	Cytochrome P450-cam	camC	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00695 - Furosemide

Targets

Enzymes

Transporters

Carriers

Predictions