DT-Web

DB01050 - Ibuprofen


Identification
Name Ibuprofen
Accession Number DB01050 (APRD00372)
Type small molecule
Description Ibuprofen, a propionic acid derivative, is a prototypical nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 206.2808
Groups approved
Monoisotopic Weight 206.13067982
Pharmacology
Indication For symptomatic treatment of rheumatoid arthritis, juvenile rheumatoid arthritis and osteoarthritis. May be used to treat mild to moderate pain and for the management of dysmenorrhea. May be used to reduce fever. Has been used with some success for treating ankylosing spondylitis, gout and psoriatic arthritis. May reduce pain, fever and inflammation of pericarditis. May be used IV with opiates to relieve moderate to severe pain. Ibuprofen lysine may be used IV to treat patent ductus arteriosus (PDA) in premature neonates.
Mechanism of action The exact mechanism of action of ibuprofen is unknown. Ibuprofen is a non-selective inhibitor of cyclooxygenase, an enzyme invovled in prostaglandin synthesis via the arachidonic acid pathway. Its pharmacological effects are believed to be due to inhibition cylooxygenase-2 (COX-2) which decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever and swelling. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Inhibition of COX-1 is thought to cause some of the side effects of ibuprofen including GI ulceration. Ibuprofen is administered as a racemic mixture. The R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo. The S-enantiomer is believed to be the more pharmacologically active enantiomer.
Absorption ~ 80% absorbed from GI tract

Time to reach peak plasma concentration = 47 minutes (suspension), 62 minutes (chewable tablets), 120 minutes (conventional tablets)
Protein binding 90-99% to whole human plasma and site II of purified albumin, binding appears to be saturable and becomes non-linear at concentrations exceeding 20 mcg/ml.
Biotransformation R-enanatiomer undergoes extensive enantiomeric conversion (53-65%) to the more active S-enantiomer in vivo. Metablized by oxidation to 2 inactive metabolites: (+)-2[4?-(2-hydroxy-2-methylpropyl)phenyl]propionic acid and (+)-2-[4?-(2-carboxypropyl)phenyl]propionic acid. Very small amounts of 1-hydroxyibuprofen and 3-hydroxyibuprofen have been recovered from urine. Cytochrome P450 2C9 is the major catalyst in the formation of oxidative metabolites. Oxidative metabolites may be conjugated to glucuronide prior to excretion.
Route of elimination Ibuprofen is rapidly metabolized and eliminated in the urine.
Toxicity

Side effects: May cause peripheral edema and fluid retention. Use caution in patients with congestive heart failure or severe uncontrolled hypertension. May cause dyspepsia, heartburn, nausea, vomiting, anorexia, diarrhea, constipation, stomatitis, flatulence, bloating, epigastric pain, and abdominal pain. Peptic ulcer and GI bleeding have been reported. May also cause dizziness, headache and nervousness. Acute renal failure accompanied by acute tubular necrosis has been reported.

Most common symptoms of overdose are abdominal pain, nausea, vomiting, lethargy, vertigo, drowsiness (somnolence), dizziness and insomnia. Other symptoms of overdose include headache, loss of consciousness, tinnitus, CNS depression, convulsions and seizures. May rarely cause metabolic acidosis, abnormal hepatic function, hyperkalemia, renal failure, dyspnea, respiratory depression, coma, acute renal failure, and apnea (primarily in very young pediatric patients).

LD50=1255mg/kg(orally in mice)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol Risk of inhibition of renal prostaglandins
Acenocoumarol The NSAID, ibuprofen, may increase the anticoagulant effect of acenocoumarol.
Acetylsalicylic acid Concomitant therapy of the NSAID, ketoprofen, and acetylsalicylic acid may result in additive adverse/toxic effects (e.g. GI bleeding). The NSAID may also limit the cardioprotective effect of acetylsalicylic acid. Occasional concomitant use may not cause clinically significant problems, but regular, frequent concomitant therapy is not recommended.
Alendronate Increased risk of gastric toxicity
Anisindione The NSAID, ibuprofen, may increase the anticoagulant effect of anisindione.
Atenolol Risk of inhibition of renal prostaglandins
Azilsartan medoxomil Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Betaxolol Nonsteroidal Anti-Inflammatory Agents such as ibuprofen may diminish the antihypertensive effect of Beta-Blockers such as betaxolol. Monitor for increases in blood pressure if a nonsteroidal anti-inflammatory agent (NSAID) is initiated/dose increased, or decreases in blood pressure if a NSAID is discontinued/dose decreased; this is particularly important if NSAID treatment is for extended periods of time. Ophthalmic beta-blockers are likely of little concern.
Bevantolol Risk of inhibition of renal prostaglandins
Bisoprolol Risk of inhibition of renal prostaglandins
Bumetanide The NSAID, ibuprofen, may antagonize the diuretic and antihypertensive effects of the loop diuretic, bumetanide.
Carteolol Risk of inhibition of renal prostaglandins
Carvedilol Risk of inhibition of renal prostaglandins
Colesevelam Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Cyclosporine Monitor for nephrotoxicity
Dicumarol The NSAID, ibuprofen, may increase the anticoagulant effect of dicumarol.
Eltrombopag Increases levels of Ibuprofen via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Esmolol Risk of inhibition of renal prostaglandins
Ethacrynic acid The NSAID, ibuprofen, may antagonize the diuretic and antihypertensive effects of the loop diuretic, ethacrynic acid.
Furosemide The NSAID, ibuprofen, may antagonize the diuretic and antihypertensive effects of the loop diuretic, furosemide.
Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Homoharringtonine Avoid combination with ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) due to the potential enhancement of homoharringtonine associated bleeding-related adverse effects. Specifically it is suggested to avoid this combination in patients with a platelet count of less than 50,000/uL.
Labetalol Risk of inhibition of renal prostaglandins
Lithium The NSAID, ibuprofen, may decrease the renal excretion of lithium. Increased risk of lithium toxicity.
Methotrexate The NSAID, ibuprofen, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Metoprolol Risk of inhibition of renal prostaglandins
Nadolol Risk of inhibition of renal prostaglandins
Oxprenolol Risk of inhibition of renal prostaglandins
Penbutolol Risk of inhibition of renal prostaglandins
Pindolol Risk of inhibition of renal prostaglandins
Practolol Risk of inhibition of renal prostaglandins
Pralatrexate NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Prasugrel Coadministration with NSAIDS used chronically may increase the risk of bleeding.
Propranolol Risk of inhibition of renal prostaglandins
Sotalol Risk of inhibition of renal prostaglandins
Tamoxifen Ibuprofen may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Ibuprofen is initiated, discontinued or dose changed.
Tolbutamide Ibuprofen, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Ibuprofen is initiated, discontinued or dose changed.
Torasemide The NSAID, ibuprofen, may decrease the diuretic and antihypertensive effect of the loop diuretic, torasemide.
Trandolapril The NSAID, Ibuprofen, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Ibuprofen is initiated, discontinued or dose changed.
Treprostinil The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Ibuprofen. Monitor for increased bleeding during concomitant thearpy.
Triflusal The metabolite of triflusal, 2-hydroxy-4-trifluoro-methyl-benzoic acid (HTB), impairs the serum protein binding of ibuprofen to the same extent as acetylsalisylic acid. Thus, the free fraction of glisentide may be increased. A dosage reduction may be required if used in combination.
Trimethoprim The strong CYP2C9 inhibitor, Ibuprofen, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Ibuprofen is initiated, discontinued or dose changed.
Vilazodone Increased risk of bleeding with concomitant use of non-steroidal anti-inflammatory drugs with vilazodone.
Voriconazole Ibuprofen, a strong CYP2C9 inhibitor, may increase the serum concentration of voriconazole by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of voriconazole if ibuprofen is initiated, discontinued or dose changed.
Warfarin Ibuprofen, a strong CYP2C9 inhibitor, may decrease the metabolism of warfarin. The antiplatelet effect of ibuprofen may also increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of warfarin if ibuprofen is initiated, discontinued or dose changed.
Food Interactions
  • Avoid alcohol
  • Food delays the time to reach peak plasma concentrations by 30-60 minutes and reduces peak plasma concentrations by 30-50%. Extent of absorption is unaffected.
  • Take with food to reduce gastric irritation.

Targets


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Chavez ML, DeKorte CJ: Valdecoxib: a review. Clin Ther. 2003 Mar;25(3):817-51. - Pubmed
  • Ouellet M, Falgueyret JP, Percival MD: Detergents profoundly affect inhibitor potencies against both cyclo-oxygenase isoforms. Biochem J. 2004 Feb 1;377(Pt 3):675-84. - Pubmed
  • Gallego-Sandin S, Novalbos J, Rosado A, Gisbert JP, Galvez-Mugica MA, Garcia AG, Pajares JM, Abad-Santos F: Effect of ibuprofen on cyclooxygenase and nitric oxide synthase of gastric mucosa: correlation with endoscopic lesions and adverse reactions. Dig Dis Sci. 2004 Sep;49(9):1538-44. - Pubmed
  • Murphey LJ, Williams MK, Sanchez SC, Byrne LM, Csiki I, Oates JA, Johnson DH, Morrow JD: Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer. Anal Biochem. 2004 Nov 15;334(2):266-75. - Pubmed
  • Sanchez-Fidalgo S, Martin-Lacave I, Illanes M, Motilva V: Angiogenesis, cell proliferation and apoptosis in gastric ulcer healing. Effect of a selective cox-2 inhibitor. Eur J Pharmacol. 2004 Nov 28;505(1-3):187-94. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7912
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Pharmacological action yes
Actions Not Available
References
  • Chavez ML, DeKorte CJ: Valdecoxib: a review. Clin Ther. 2003 Mar;25(3):817-51. - Pubmed
  • Patrignani P: Aspirin insensitive eicosanoid biosynthesis in cardiovascular disease. Thromb Res. 2003 Jun 15;110(5-6):281-6. - Pubmed
  • Gupta K, Kaub CJ, Carey KN, Casillas EG, Selinsky BS, Loll PJ: Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors. Bioorg Med Chem Lett. 2004 Feb 9;14(3):667-71. - Pubmed
  • Martic M, Tatic I, Markovic S, Kujundzic N, Kostrun S: Synthesis, biological activity and molecular modeling studies of novel COX-1 inhibitors. Eur J Med Chem. 2004 Feb;39(2):141-51. - Pubmed
  • Hillarp A: [Acetylsalicylic acid resistance--clinical diagnosis with unclear mechanism] Lakartidningen. 2004 Nov 4;101(45):3504-6, 3508-9. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. - Pubmed
  • Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. - Pubmed
  • Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. - Pubmed
  • Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. - Pubmed
  • Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. - Pubmed
  • Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. - Pubmed
  • Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. - Pubmed
  • Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. - Pubmed
  • Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. - Pubmed
  • Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. - Pubmed
  • Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. - Pubmed
DTHybrid score 0.9033
Apoptosis regulator Bcl-2
Name Apoptosis regulator Bcl-2
Gene Name BCL2
Pharmacological action unknown
Actions modulator
References
  • Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. - Pubmed
DTHybrid score 0.2854
Thrombomodulin
Name Thrombomodulin
Gene Name THBD
Pharmacological action unknown
Actions modulator
References
  • Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. - Pubmed
DTHybrid score 0.2275
Tissue-type plasminogen activator
Name Tissue-type plasminogen activator
Gene Name PLAT
Pharmacological action unknown
Actions negative modulator
References
  • Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. - Pubmed
DTHybrid score 0.8085
Fatty acid-binding protein, intestinal
Name Fatty acid-binding protein, intestinal
Gene Name FABP2
Pharmacological action unknown
Actions binder
References
  • Velkov T, Chuang S, Wielens J, Sakellaris H, Charman WN, Porter CJ, Scanlon MJ: The interaction of lipophilic drugs with intestinal fatty acid-binding protein. J Biol Chem. 2005 May 6;280(18):17769-76. Epub 2005 Feb 18. - Pubmed
DTHybrid score 0.2114
Peroxisome proliferator-activated receptor gamma
Name Peroxisome proliferator-activated receptor gamma
Gene Name PPARG
Pharmacological action unknown
Actions activator
References
  • Dill J, Patel AR, Yang XL, Bachoo R, Powell CM, Li S: A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons. J Neurosci. 2010 Jan 20;30(3):963-72. doi: 10.1523/JNEUROSCI.5045-09.2010. - Pubmed
DTHybrid score 1.0687
Cystic fibrosis transmembrane conductance regulator
Name Cystic fibrosis transmembrane conductance regulator
Gene Name CFTR
Pharmacological action unknown
Actions inhibitor
References
  • Devor DC, Schultz BD: Ibuprofen inhibits cystic fibrosis transmembrane conductance regulator-mediated Cl- secretion. J Clin Invest. 1998 Aug 15;102(4):679-87. - Pubmed
DTHybrid score 0.4332

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF: New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Carlile DJ, Hakooz N, Bayliss MK, Houston JB: Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans. Br J Clin Pharmacol. 1999 Jun;47(6):625-35. - Pubmed
DTHybrid score 0.8481
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. - Pubmed
DTHybrid score 0.6228
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5667
UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4665
UDP-glucuronosyltransferase 1-3
Name UDP-glucuronosyltransferase 1-3
Gene Name UGT1A3
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4093
UDP-glucuronosyltransferase 1-9
Name UDP-glucuronosyltransferase 1-9
Gene Name UGT1A9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4803
UDP-glucuronosyltransferase 2B4
Name UDP-glucuronosyltransferase 2B4
Gene Name UGT2B4
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3029
UDP-glucuronosyltransferase 2B7
Name UDP-glucuronosyltransferase 2B7
Gene Name UGT2B7
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4917
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Actions inhibitor
References
  • Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. - Pubmed
DTHybrid score 0.9033
Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Actions inhibitor
References
  • Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. - Pubmed
DTHybrid score 0.7912

Transporters


Solute carrier organic anion transporter family member 2B1
Name Solute carrier organic anion transporter family member 2B1
Gene Name SLCO2B1
Actions substrate
References
  • Satoh H, Yamashita F, Tsujimoto M, Murakami H, Koyabu N, Ohtani H, Sawada Y: Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos. 2005 Apr;33(4):518-23. Epub 2005 Jan 7. - Pubmed
DTHybrid score 0.3818
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. - Pubmed
DTHybrid score 0.7214
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions inhibitor
References
  • Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. - Pubmed
DTHybrid score 0.3758
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions inhibitor
References
  • Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. - Pubmed
DTHybrid score 0.3716
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions inhibitor
References
  • Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. - Pubmed
DTHybrid score 0.412
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. - Pubmed
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed
  • Uwai Y, Saito H, Inui K: Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter. Eur J Pharmacol. 2000 Dec 1;409(1):31-6. - Pubmed
  • Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. - Pubmed
DTHybrid score 0.6844
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed
  • Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. - Pubmed
DTHybrid score 0.5235
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions inhibitor
References
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed
  • Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem. 2000 Feb 11;275(6):4507-12. - Pubmed
DTHybrid score 0.3968

Carriers


Solute carrier organic anion transporter family member 2B1
Name Solute carrier organic anion transporter family member 2B1
Gene Name SLCO2B1
Actions
References Not Available
DTHybrid score 0.3818
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.7214
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions
References Not Available
DTHybrid score 0.3758
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions
References Not Available
DTHybrid score 0.3716
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions
References Not Available
DTHybrid score 0.412
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions
References Not Available
DTHybrid score 0.6844
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions
References Not Available
DTHybrid score 0.5235
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions
References Not Available
DTHybrid score 0.3968

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.6946
4200 Cytochrome P450 1A2 CYP1A2 0.3826
4119 Cytochrome P450 2D6 CYP2D6 0.3481
4118 Cytochrome P450 3A5 CYP3A5 0.3139
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.2936
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.2811
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.2678
6143 Solute carrier family 22 member 7 SLC22A7 0.2434
6030 Cytochrome P450 2B6 CYP2B6 0.225
6107 Cytochrome P450 3A7 CYP3A7 0.2219
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1822
6013 Cytochrome P450 2E1 CYP2E1 0.1659
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1519
6024 Cytochrome P450 1A1 CYP1A1 0.1464
5718 Cytochrome P450 2A6 CYP2A6 0.1328
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.1327
776 Bile salt export pump ABCB11 0.1305
6145 Solute carrier family 22 member 1 SLC22A1 0.1235
738 Monocarboxylate transporter 1 SLC16A1 0.1152
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.1134
6141 Sodium/bile acid cotransporter SLC10A1 0.1132
6136 Multidrug resistance-associated protein 5 ABCC5 0.1091
3833 Plasma serine protease inhibitor SERPINA5 0.1063
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.1035
118 Organic cation/carnitine transporter 2 SLC22A5 0.1
267 Plasminogen activator inhibitor 1 SERPINE1 0.0972
275 Arachidonate 5-lipoxygenase ALOX5 0.096
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0959
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0951
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0924
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0914
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0908
6106 Cytochrome P450 2C18 CYP2C18 0.0906
6144 Solute carrier family 22 member 2 SLC22A2 0.0865
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0863
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0863
1898 Cytochrome P450 1B1 CYP1B1 0.0845
234 Plasminogen PLG 0.0842
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.084
696 Kappa-type opioid receptor OPRK1 0.0837
6148 Multidrug resistance-associated protein 7 ABCC10 0.0836
467 Delta-type opioid receptor OPRD1 0.0828
2353 Apolipoprotein(a) LPA 0.0823
1959 Platelet factor 4 PF4 0.0816
3865 Serpin B6 SERPINB6 0.0815
1986 Ceruloplasmin CP 0.0814
847 Mu-type opioid receptor OPRM1 0.0804
3939 Amine oxidase [flavin-containing] B MAOB 0.0739
19 Coagulation factor VIII F8 0.0709
6137 Multidrug resistance-associated protein 6 ABCC6 0.0672
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0668
46 Coagulation factor V F5 0.0663
4604 Liver carboxylesterase 1 CES1 0.0652
2072 Endothelial protein C receptor PROCR 0.0639
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0633
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0629
3811 Cytochrome P450 19A1 CYP19A1 0.0618
6020 Aldehyde oxidase AOX1 0.0616
70 Type-1 angiotensin II receptor AGTR1 0.0579
1245 Vitamin K-dependent protein S PROS1 0.0576
2183 Fatty acid-binding protein, adipocyte FABP4 0.0566
459 Retinoic acid receptor RXR-alpha RXRA 0.0554
1757 Myeloperoxidase MPO 0.0544
136 Estrogen receptor ESR1 0.0543
6228 Nuclear receptor coactivator 1 NCOA1 0.0535
6147 Solute carrier family 22 member 3 SLC22A3 0.0514
2853 14 kDa fatty acid-binding protein Not Available 0.0514
817 DNA topoisomerase 2-alpha TOP2A 0.051
492 Histamine H1 receptor HRH1 0.0507
5923 Microtubule-associated protein tau MAPT 0.0499
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0499
5924 Microtubule-associated protein 4 MAP4 0.0499
3810 Catechol O-methyltransferase COMT 0.0494
146 Androgen receptor AR 0.0479
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0477
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0476
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0474
6102 Arylamine N-acetyltransferase 2 NAT2 0.0468
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0465
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0464
373 Transthyretin TTR 0.0459
558 Solute carrier family 12 member 1 SLC12A1 0.0456
1852 Microtubule-associated protein 2 MAP2 0.0454
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0454
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0446
833 Organic cation/carnitine transporter 1 SLC22A4 0.0443
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0443
29 Tubulin beta-1 chain TUBB1 0.0426
891 Dihydropteroate synthase folP 0.0425
5359 Dihydropteroate synthase folP 0.0425
7175 Dihydropteroate synthase sulI 0.0425
824 Sodium-dependent serotonin transporter SLC6A4 0.0424
527 Prostacyclin receptor PTGIR 0.042
54 Prothrombin F2 0.0415
33 Cystine/glutamate transporter SLC7A11 0.0415
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0414
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0414
6149 Solute carrier family 22 member 10 SLC22A10 0.0408
731 HIV-1 protease HIV-1 protease 0.0407
3834 Nidogen-1 NID1 0.0406
672 Prostaglandin F2-alpha receptor PTGFR 0.0405
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0397
723 Cytosolic phospholipase A2 PLA2G4A 0.0392
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0373
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0372
502 5-hydroxytryptamine 2A receptor HTR2A 0.0366
6167 Organic solute transporter subunit beta OSTB 0.0364
6166 Organic solute transporter subunit alpha OSTA 0.0363
556 Alpha-1A adrenergic receptor ADRA1A 0.0361
22 30S ribosomal protein S4 rpsD 0.0357
6714 30S ribosomal protein S4 rpsD 0.0357
3923 Cholinesterase BCHE 0.0355
1349 Plasminogen activator inhibitor 2 SERPINB2 0.0353
756 Sex hormone-binding globulin SHBG 0.0352
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0351
645 Penicillin-binding protein 1A mrcA 0.0341
5805 Penicillin-binding protein 1A ponA 0.0341
6185 Penicillin-binding protein 1A mrcA 0.0341
6799 Penicillin-binding protein 1A pbpA 0.0341
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0338
140 30S ribosomal protein S9 rpsI 0.0336
6719 30S ribosomal protein S9 rpsI 0.0336
6725 30S ribosomal protein S9 rpsI 0.0336
5880 Thrombopoietin receptor MPL 0.0336
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0335
540 Sodium-dependent noradrenaline transporter SLC6A2 0.033
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0326
871 Glucocorticoid receptor NR3C1 0.0325
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0324
3011 Suppressor of tumorigenicity protein 14 ST14 0.0323
543 Penicillin-binding protein 1B mrcB 0.0321
6186 Penicillin-binding protein 1B ponB 0.0321
6822 Penicillin-binding protein 1b pbp1b 0.0321
6844 Penicillin-binding protein 1b pbp1b 0.0321
504 Mast/stem cell growth factor receptor KIT 0.0319
633 Penicillin-binding proteins 1A/1B pbpA 0.0317
53 Solute carrier family 12 member 5 SLC12A5 0.0311
663 Solute carrier family 12 member 4 SLC12A4 0.0311
6241 Nuclear receptor coactivator 2 NCOA2 0.031
489 Monocarboxylate transporter 2 SLC16A7 0.0307
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0304
26 Vascular endothelial growth factor receptor 3 FLT4 0.0304
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0302
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0298
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0298
6043 Putative G-protein coupled receptor 44 GPR44 0.0298
6599 HTH-type transcriptional regulator ttgR ttgR 0.0297
831 D(2) dopamine receptor DRD2 0.0295
791 Urokinase plasminogen activator surface receptor PLAUR 0.0294
869 Estrogen receptor beta ESR2 0.0294
5626 Nucleoside diphosphate kinase B NME2 0.0292
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0291
32 Vascular endothelial growth factor receptor 1 FLT1 0.0291
2211 Fatty acid-binding protein, heart FABP3 0.029
6220 Aryl hydrocarbon receptor AHR 0.029
310 Solute carrier family 12 member 2 SLC12A2 0.0288
2981 Phospholipase A2, membrane associated PLA2G2A 0.0288
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0288
6033 High affinity interleukin-8 receptor A CXCR1 0.0286
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0286
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0284
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0282
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0275
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0275
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0272
24 Thymidylate synthase TMP1 0.0267
359 Thymidylate synthase TYMS 0.0267
2626 Thymidylate synthase thyA 0.0267
2729 Thymidylate synthase thyA 0.0267
5352 Thymidylate synthase THYA 0.0267
2207 Rhodopsin RHO 0.0267
320 5-hydroxytryptamine 1A receptor HTR1A 0.0267
6026 Alcohol dehydrogenase 6 ADH6 0.0266
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0266
468 Cytochrome P450 4A11 CYP4A11 0.0266
6031 Cytochrome P450 3A43 CYP3A43 0.0264
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0262
3312 Fatty acid-binding protein, brain FABP7 0.0261
766 Beta-2 adrenergic receptor ADRB2 0.026
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0258
407 Vascular endothelial growth factor receptor 2 KDR 0.0257
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0256
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0256
3616 Fatty acid-binding protein, epidermal FABP5 0.0255
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0255
5431 Lipid binding protein Not Available 0.0255
5433 UPF0230 protein TM_1468 TM_1468 0.0255
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0254
703 NADPH azoreductase azr 0.0254
6012 Tryptophan 2,3-dioxygenase TDO2 0.0251
5294 Nucleoside diphosphate kinase A NME1 0.025
438 Taste receptor type 1 member 2 TAS1R2 0.0248
244 Angiotensin-converting enzyme ACE 0.0248
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0242
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0242
3947 Xanthine dehydrogenase/oxidase XDH 0.024
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.024
811 Translocator protein TSPO 0.0239
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0239
228 Beta platelet-derived growth factor receptor PDGFRB 0.0239
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0236
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0236
341 5-hydroxytryptamine 3 receptor HTR3A 0.0236
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0236
3587 Gastrotropin FABP6 0.0235
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0235
380 Cytochrome P450 17A1 CYP17A1 0.0235
632 Alpha-1B adrenergic receptor ADRA1B 0.0234
952 Dipeptidyl peptidase 4 DPP4 0.0232
404 DNA gyrase subunit A gyrA 0.0231
6224 DNA gyrase subunit A gyrA 0.0231
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.023
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0229
1 Peptidoglycan synthetase ftsI ftsI 0.0229
4155 Peptidoglycan synthetase ftsI ftsI 0.0229
3941 Amine oxidase [flavin-containing] A MAOA 0.0227
904 Glutathione S-transferase P GSTP1 0.0226
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0226
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0226
130 Prostacyclin synthase PTGIS 0.0226
260 Cytochrome P450 51 ERG11 0.0225
761 Cytochrome P450 51 ERG11 0.0225
3163 Cytochrome P450 51 cyp51 0.0225
183 Vascular endothelial growth factor A VEGFA 0.0225
844 Epidermal growth factor receptor EGFR 0.0224
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0223
6042 Prostaglandin reductase 2 PTGR2 0.0223
357 Carbonic anhydrase 2 CA2 0.0222
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
1650 Heme carrier protein 1 SLC46A1 0.0221
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.022
592 Carbonic anhydrase 4 CA4 0.0217
338 DNA polymerase UL30 0.0216
379 DNA polymerase UL54 0.0216
697 DNA polymerase ORF28 0.0216
2482 DNA polymerase 43 0.0216
4104 DNA polymerase BALF5 0.0216
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0215
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0215
23 D(1A) dopamine receptor DRD1 0.0213
6677 Myelin P2 protein PMP2 0.0213
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0213
115 Penicillin-binding protein 2 mrdA 0.0213
6069 Penicillin-binding protein 2 mrdA 0.0213
6118 Penicillin-binding protein 2 penA 0.0213
6187 Penicillin-binding protein 2 pbpA 0.0213
6686 Penicillin-binding protein 2 pbp2 0.0213
6939 Penicillin-binding protein 2 mrdA 0.0213
7163 Penicillin-binding protein 2 pbpA 0.0213
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0212
6459 Glycodelin PAEP 0.0208
124 Histamine H2 receptor HRH2 0.0207
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0206
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0206
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0206
853 Farnesyl pyrophosphate synthetase FDPS 0.0205
590 5-hydroxytryptamine 2C receptor HTR2C 0.0205
295 Carbonic anhydrase 1 CA1 0.0204
777 Tumor necrosis factor TNF 0.0203
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0203
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.02
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0199
122 P2Y purinoceptor 12 P2RY12 0.0199
283 SEC14-like protein 2 SEC14L2 0.0199
2016 Dipeptidase 1 DPEP1 0.0197
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0196
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0196
737 Mineralocorticoid receptor NR3C2 0.0196
4132 Chloride channel protein ClC-Ka CLCNKA 0.0194
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0191
1648 Elastin ELN 0.0191
3866 Serum amyloid A protein SAA1 0.019
1200 AMBP protein AMBP 0.019
1932 Apolipoprotein E APOE 0.019
1630 Integrin beta-2 ITGB2 0.019
3809 Estrogen-related receptor gamma ESRRG 0.019
1507 Cytochrome c CYCS 0.0189
2320 Thymidine kinase, cytosolic TK1 0.0189
1313 Lactoylglutathione lyase GLO1 0.0188
1405 Thiopurine S-methyltransferase TPMT 0.0187
318 Alpha-2A adrenergic receptor ADRA2A 0.0187
614 Progesterone receptor PGR 0.0186
465 Calmodulin CALM1 0.0186
1159 Interleukin-6 IL6 0.0185
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0184
5353 Glutamate decarboxylase alpha gadA 0.0183
1760 Aminopeptidase N ANPEP 0.0182
6843 Aminopeptidase N pepN 0.0182
6138 Multidrug resistance protein 3 ABCB4 0.0182
1050 Bile salt sulfotransferase SULT2A1 0.0182
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0181
789 Alpha-1D adrenergic receptor ADRA1D 0.0181
4217 Telomerase reverse transcriptase TERT 0.0181
950 Alpha platelet-derived growth factor receptor PDGFRA 0.018
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.018
117 Sterol O-acyltransferase 1 SOAT1 0.0178
1192 Sulfotransferase 1A1 SULT1A1 0.0177
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0174
3917 Methylenetetrahydrofolate reductase MTHFR 0.0174
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0173
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0173
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0172
1629 Transcription factor AP-1 JUN 0.0172
1389 Transforming growth factor beta-1 TGFB1 0.0169
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0169
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0168
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0167
1198 Serum paraoxonase/arylesterase 1 PON1 0.0167
6223 Penicillin-binding protein 1C pbpC 0.0167
1074 Urokinase-type plasminogen activator PLAU 0.0166
1867 Major prion protein PRNP 0.0163
594 Thyroxine-binding globulin SERPINA7 0.0161
193 Beta-1 adrenergic receptor ADRB1 0.016
332 Beta-lactamase blaZ 0.0159
2478 Beta-lactamase ampC 0.0159
2613 Beta-lactamase ampC 0.0159
2635 Beta-lactamase ampC 0.0159
2700 Beta-lactamase penP 0.0159
5445 Beta-lactamase blaB 0.0159
6019 Beta-lactamase SHV-7 0.0159
6701 Beta-lactamase cphA 0.0159
3639 Thymidine phosphorylase deoA 0.0159
3936 Thymidine phosphorylase TYMP 0.0159
6221 Steroid hormone receptor ERR1 ESRRA 0.0159
6500 Phospholipase A2 PLA2G1B 0.0158
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0158
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0157
477 DNA topoisomerase 4 subunit A parC 0.0157
886 DNA topoisomerase 4 subunit A parC 0.0157
6226 DNA topoisomerase 4 subunit A parC 0.0157
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0157
6103 Arylamine N-acetyltransferase 1 NAT1 0.0156
3233 Bile acid receptor NR1H4 0.0156
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0154
6182 Cytochrome P450 2J2 CYP2J2 0.0154
2514 Phosphocarrier protein HPr ptsH 0.0154
5689 Phosphocarrier protein HPr ptsH 0.0154
3602 Anti-sigma F factor antagonist spoIIAA 0.0154
5686 Potassium voltage-gated channel subfamily C member 4 KCNC4 0.0154
6044 Serum paraoxonase/lactonase 3 PON3 0.0154
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0153
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0152
161 Tubulin beta chain TUBB 0.0151
312 Tubulin beta chain TUB2 0.0151
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
293 Gamma-glutamyl hydrolase GGH 0.0149
758 Thyroid hormone receptor alpha THRA 0.0148
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0145
319 Opioid receptor, sigma 1 OPRS1 0.0145
342 P protein [Includes: DNA-directed DNA polymerase P 0.0145
612 P protein [Includes: DNA-directed DNA polymerase P 0.0145
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0143
713 Sodium-dependent dopamine transporter SLC6A3 0.0143
6126 Carbonic anhydrase 7 CA7 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
572 Integrin alpha-L ITGAL 0.0142
4122 Histone deacetylase 2 HDAC2 0.0142
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0142
6209 30S ribosomal protein S19 rpsS 0.0141
6712 30S ribosomal protein S19 rpsS 0.0141
6726 30S ribosomal protein S19 rpsS 0.0141
6207 30S ribosomal protein S14 rpsN 0.0141
4192 DNA topoisomerase 2-beta TOP2B 0.0141
1039 Histone deacetylase 9 HDAC9 0.0141
365 Dihydrofolate reductase DHFR 0.014
2381 Dihydrofolate reductase DFR1 0.014
2833 Dihydrofolate reductase Not Available 0.014
2931 Dihydrofolate reductase folA 0.014
3544 Dihydrofolate reductase folA 0.014
3682 Dihydrofolate reductase folA 0.014
6642 Dihydrofolate reductase folA 0.014
6756 Dihydrofolate reductase dfrA 0.014
823 Fibroblast growth factor receptor 2 FGFR2 0.014
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0139
1275 Estrogen sulfotransferase SULT1E1 0.0139
1353 DNA topoisomerase 1 TOP1 0.0136
3552 DNA topoisomerase 1 topA 0.0136
1130 Lithostathine 1 alpha REG1A 0.0134
4542 Glutaminase 1 glsA1 0.0134
4544 Glutaminase 1 glsA1 0.0134
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0133
346 Thyroid hormone receptor beta-1 THRB 0.0132
185 Vasopressin V1a receptor AVPR1A 0.0132
165 FL cytokine receptor FLT3 0.0131
2530 Protein kinase C theta type PRKCQ 0.0131
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0131
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0131
5787 Angiopoietin-1 receptor TEK 0.0131
4318 Siroheme synthase cysG 0.013
3307 Acriflavine resistance protein B acrB 0.013
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0129
322 Vasopressin V2 receptor AVPR2 0.0129
1141 Sialidase-1 NEU1 0.0129
64 Neuraminidase NA 0.0129
641 Neuraminidase NA 0.0129
2676 Neuraminidase NA 0.0129
3026 Neuraminidase NA 0.0129
3519 Neuraminidase NA 0.0129
6007 Neuraminidase NA 0.0129
6218 Pannexin-1 PANX1 0.0128
4210 Toll-like receptor 4 TLR4 0.0128
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0127
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0127
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0127
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0126
3685 Catabolite gene activator crp 0.0126
4655 Adenylate cyclase cyaC 0.0126
4759 Adenylate cyclase cyaB2 0.0126
4120 NADPH--cytochrome P450 reductase POR 0.0126
885 5-hydroxytryptamine 1B receptor HTR1B 0.0125
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0125
3119 Fimbrial protein pilE1 0.0125
65 Matrix metalloproteinase-9 Not Available 0.0124
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0123
850 Vasopressin V1b receptor AVPR1B 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0122
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0121
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0119
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0119
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0118
936 Ephrin type-A receptor 2 EPHA2 0.0116
3453 Alkaline phosphatase phoA 0.0116
725 5-hydroxytryptamine 1D receptor HTR1D 0.0116
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0115
6151 Monocarboxylate transporter 10 SLC16A10 0.0115
6014 Cytochrome P450 2A13 CYP2A13 0.0114
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0114
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0114
1618 High affinity nerve growth factor receptor NTRK1 0.0114
5150 Endo-1,4-beta-xylanase Y xynY 0.0113
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0113
2249 Aspartate aminotransferase aspC 0.0112
2671 Aspartate aminotransferase aspC 0.0112
5490 Aspartate aminotransferase Not Available 0.0112
1656 CYP2B protein CYP2B 0.0112
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0112
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0112
500 Monocarboxylate transporter 4 SLC16A3 0.0111
759 Free fatty acid receptor 1 FFAR1 0.011
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.011
2503 Phosphomannomutase/phosphoglucomutase algC 0.011
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0109
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0108
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0108
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0108
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0108
4760 Mll3241 protein mll3241 0.0107
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0107
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0107
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0107
908 Glutathione S-transferase theta-1 GSTT1 0.0107
2616 Ganglioside GM2 activator GM2A 0.0104
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0103
638 D(3) dopamine receptor DRD3 0.0103
4238 50S ribosomal protein L4 rplD 0.0102
5578 50S ribosomal protein L4 rplD 0.0102
6173 50S ribosomal protein L4 rplD 0.0102
6219 50S ribosomal protein L4 rplD 0.0102
5482 Sialidase-2 NEU2 0.0101
436 5-hydroxytryptamine 2B receptor HTR2B 0.01
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.01
5818 Folate receptor alpha FOLR1 0.01
4773 Deoxycytidine kinase DCK 0.0099
3932 Glutathione S-transferase A2 GSTA2 0.0099
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0099
4221 Vascular endothelial growth factor VEGF 0.0099
5816 Cadherin-5 CDH5 0.0099
3760 Penicillin-binding protein 5 precursor dacA 0.0098
2236 Casein kinase II subunit alpha CSNK2A1 0.0098
1439 Lactotransferrin LTF 0.0098
5650 NimA-related protein DR_0842 0.0098
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0098
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0097
819 Penicillin-binding protein 4 dacB 0.0096
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0096
1053 BC269730_2 FADS1 0.0096
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0096
1395 Sodium/calcium exchanger 1 SLC8A1 0.0096
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
427 Substance-P receptor TACR1 0.0095
566 Serotransferrin TF 0.0094
1714 Mitogen-activated protein kinase 3 MAPK3 0.0094
867 Penicillin-binding protein 3 pbpC 0.0094
6119 Penicillin-binding protein 3 pbp3 0.0094
7154 Penicillin-binding protein 3 pbp3 0.0094
7157 Penicillin-binding protein 3 LMHCC_2184 0.0094
7162 Penicillin-binding protein 3 pbpB 0.0094
7172 Penicillin-binding protein 3 pbp3 0.0094
4237 50S ribosomal protein L22 rplV 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
10 Glycogen phosphorylase, liver form PYGL 0.0093
702 UMP-CMP kinase CMPK1 0.0092
1654 Interleukin-1 beta IL1B 0.0092
199 Monocarboxylate transporter 8 SLC16A2 0.0091
482 Glycine receptor subunit alpha-1 GLRA1 0.0091
232 Corticosteroid-binding globulin SERPINA6 0.009
634 Squalene monooxygenase SQLE 0.0089
7196 Squalene monooxygenase ERG1 0.0089
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0089
4116 Dihydropteroate synthetase Not Available 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0086
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0085
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0085
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0085
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0085
5798 Mitogen-activated protein kinase 11 MAPK11 0.0085
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0085
6131 Carbonic anhydrase 14 CA14 0.0085
6837 Serine/threonine-protein kinase 17B STK17B 0.0084
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0084
5300 Antigen peptide transporter 1 TAP1 0.0084
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0082
6755 Poliovirus receptor PVR 0.0082
5646 Galactokinase GALK1 0.0081
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0081
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0081
5302 TrwB trwB 0.0081
5265 FtsH ftsH 0.0081
1010 Cytochrome P450 51A1 CYP51A1 0.008
7 Nitric oxide synthase, inducible NOS2 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0079
6171 Solute carrier family 28 member 3 SLC28A3 0.0079
284 DNA-directed RNA polymerase beta chain rpoB 0.0079
5773 DNA-directed RNA polymerase beta chain rpoB 0.0079
2539 Tubulin alpha-1 chain TUBA4A 0.0078
860 Nicotinamide N-methyltransferase NNMT 0.0078
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0078
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0078
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0078
699 Nicotinic acid receptor 1 GPR109A 0.0078
928 Nicotinic acid receptor 2 GPR109B 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0077
511 5-hydroxytryptamine 1F receptor HTR1F 0.0077
469 Annexin A1 ANXA1 0.0077
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0077
394 Calcineurin subunit B isoform 1 PPP3R1 0.0077
6753 Apolipoprotein M APOM 0.0077
768 FK506-binding protein 1A FKBP1A 0.0077
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0077
6742 Recoverin RCVRN 0.0077
6743 Non-fluorescent flavoprotein luxF 0.0077
2528 Fatty acid metabolism regulator protein fadR 0.0077
6740 Fatty acid metabolism regulator protein fadR 0.0077
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0077
6751 Gag polyprotein gag 0.0077
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0077
6747 Chalcone/stilbene synthase family protein MT1417 0.0077
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0077
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0076
6749 Polyprotein Not Available 0.0076
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0076
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0076
1517 Beta-3 adrenergic receptor ADRB3 0.0075
494 Caspase-1 CASP1 0.0075
2599 Tyrosine-protein kinase HCK HCK 0.0075
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0075
362 Melatonin receptor type 1B MTNR1B 0.0075
571 Melatonin receptor type 1A MTNR1A 0.0075
207 Glutathione synthetase GSS 0.0075
5269 Glutathione synthetase gshB 0.0075
3808 Dihydropteroate synthase 2 folP2 0.0074
3601 Dihydropteroate synthase 1 folP1 0.0074
3807 Dihydropteroate synthase 1 folP1 0.0074
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0074
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0073
5312 Kinesin-like protein KIF1A KIF1A 0.0073
537 ATP synthase delta chain, mitochondrial ATP5D 0.0072
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0072
1291 cAMP response element-binding protein CREB1 0.0072
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0072
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0072
1152 Glycogen phosphorylase, muscle form PYGM 0.0072
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0071
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
3937 Fatty-acid amide hydrolase FAAH 0.0071
718 Folate receptor gamma FOLR3 0.0071
299 Folate receptor beta FOLR2 0.0071
804 Mitochondrial folate transporter/carrier SLC25A32 0.0071
1881 Hexokinase-1 HK1 0.007
921 Glutamate receptor 2 GRIA2 0.007
49 Endothelin B receptor EDNRB 0.007
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.007
88 Retinoic acid receptor RXR-beta RXRB 0.0069
5961 Insulin INS 0.0069
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0068
822 Aldose reductase AKR1B1 0.0068
2892 Acetylglutamate kinase argB 0.0068
3550 Acetylglutamate kinase argB 0.0068
2371 Pantothenate kinase coaA 0.0068
2615 Chemotaxis protein cheA cheA 0.0068
3014 Ribonuclease UK114 HRSP12 0.0068
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0067
5428 Replication protein repA 0.0067
3617 Non-heme chloroperoxidase cpo 0.0067
5426 Non-heme chloroperoxidase cpo 0.0067
629 Alpha-2B adrenergic receptor ADRA2B 0.0067
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0067
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0067
3018 HTH-type transcriptional regulator malT malT 0.0067
3856 Fibroblast growth factor receptor 3 FGFR3 0.0067
705 Glutamate receptor 1 GRIA1 0.0067
661 ADP/ATP translocase 1 SLC25A4 0.0067
6527 Lymphocyte antigen 96 LY96 0.0067
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0066
36 Insulin receptor INSR 0.0066
578 Endothelin-1 receptor EDNRA 0.0066
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0065
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0065
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0065
3957 Adenosine deaminase ADA 0.0065
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0065
6501 Fatty acid-binding protein, liver FABP1 0.0065
4103 Proteasome subunit beta type 2 PSMB2 0.0064
4102 Proteasome subunit beta type 5 PSMB5 0.0064
4101 Proteasome subunit beta type 1 PSMB1 0.0064
2727 S-adenosylmethionine synthetase metK 0.0064
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0064
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0064
716 5-hydroxytryptamine 7 receptor HTR7 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
2077 Caspase-3 CASP3 0.0063
133 Dihydropterate synthase sulI 0.0063
408 Riboflavin kinase RFK 0.0062
528 5-hydroxytryptamine 1E receptor HTR1E 0.0062
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0061
6122 Carbonic anhydrase 3 CA3 0.0061
6750 ADP-ribosylation factor 6 ARF6 0.0061
6524 Protein tonB tonB 0.0061
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0061
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0061
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0061
3823 Cytokine receptor common gamma chain IL2RG 0.0061
291 Nitric-oxide synthase, endothelial NOS3 0.006
2391 Ferrochelatase hemH 0.006
6502 Ferrochelatase DKFZp686P18130 0.006
1591 Ferrochelatase, mitochondrial FECH 0.006
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
4226 Uridine phosphorylase 2 UPP2 0.006
1541 Metalloproteinase mmp20 0.006
4178 DNA repair protein RAD51 homolog 1 RAD51 0.006
5643 General secretion pathway protein E epsE 0.006
3794 Osmolarity sensor protein envZ envZ 0.006
5644 Sensor protein phoQ phoQ 0.006
5641 Rod shape-determining protein MreB TM_0588 0.006
5649 Potassium-transporting ATPase B chain kdpB 0.0059
5642 Chaperone clpB clpB 0.0059
5645 DNA topoisomerase 4 subunit B parE 0.0059
6227 DNA topoisomerase 4 subunit B parE 0.0059
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0059
1196 Complement decay-accelerating factor CD55 0.0059
992 Protein tyrosine kinase 2 beta PTK2B 0.0059
3007 Carbonic anhydrase 12 CA12 0.0059
4205 Carbonic anhydrase 9 CA9 0.0059
3382 Glycolipid transfer protein GLTP 0.0058
2958 Probable tautomerase ydcE pptA 0.0058
106 Cannabinoid receptor 2 CNR2 0.0058
2573 Cocaine esterase cocE 0.0058
7263 Cocaine esterase Not Available 0.0058
2449 Tubulin alpha-3 chain TUBA1A 0.0058
461 Glycine receptor subunit alpha-3 GLRA3 0.0058
3115 Ras-related protein Rab-9 RAB9A 0.0057
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
707 72 kDa type IV collagenase MMP2 0.0057
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0057
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0057
2852 DNA mismatch repair protein mutL mutL 0.0057
6146 High affinity copper uptake protein 1 SLC31A1 0.0056
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0056
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0056
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0056
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0056
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0056
2251 Thymidylate kinase tmk 0.0056
2254 Thymidylate kinase DTYMK 0.0056
3522 Thymidylate kinase tmk 0.0056
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0055
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0055
6316 ADP-ribosylation factor 1 ARF1 0.0055
68 Cannabinoid receptor 1 CNR1 0.0055
976 Platelet glycoprotein IX GP9 0.0055
4225 Uridine phosphorylase 1 UPP1 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0055
828 Phenylalanine-4-hydroxylase PAH 0.0054
3109 Phenylalanine-4-hydroxylase phhA 0.0054
5934 Cytochrome P450 26A1 CYP26A1 0.0054
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
4252 Penicillin-binding protein 5 dacA 0.0053
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0053
1721 Glycogen synthase kinase-3 beta GSK3B 0.0053
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0053
162 Retinoic acid receptor gamma-1 RARG 0.0053
94 5-hydroxytryptamine 4 receptor HTR4 0.0053
724 Interleukin-2 receptor alpha chain IL2RA 0.0053
717 Interleukin-2 receptor subunit beta IL2RB 0.0053
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0053
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0052
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0052
6493 Cytochrome c oxidase subunit 6C COX6C 0.0052
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0052
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0052
159 Penicillin-binding protein 2B penA 0.0052
6121 Penicillin-binding protein 2B penA 0.0052
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0052
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0052
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0052
4751 Mitogen-activated protein kinase 12 MAPK12 0.0052
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0052
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0052
6559 Cytochrome c oxidase subunit 2 ctaC 0.0052
6669 Cytochrome c oxidase subunit 2 ctaC 0.0052
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0052
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0052
6558 Cytochrome c oxidase subunit 1 ctaD 0.0052
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0052
2397 Dihydroxyacetone kinase dhaK 0.0052
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0052
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0052
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0052
780 Retinoic acid receptor RXR-gamma RXRG 0.0052
413 Amidophosphoribosyltransferase PPAT 0.0052
2515 Amidophosphoribosyltransferase purF 0.0052
3714 Amidophosphoribosyltransferase purF 0.0052
2808 Chloramphenicol acetyltransferase 3 cat3 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
3822 Actin, alpha skeletal muscle ACTA1 0.0051
474 Acetylcholinesterase ACHE 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0051
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.005
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.005
4692 A/G-specific adenine glycosylase mutY 0.005
864 Gag-Pol polyprotein gag-pol 0.005
2237 Gag-Pol polyprotein gag-pol 0.005
2326 Gag-Pol polyprotein gag-pol 0.005
2451 Gag-Pol polyprotein gag-pol 0.005
2901 Gag-Pol polyprotein gag-pol 0.005
3165 Gag-Pol polyprotein gag-pol 0.005
3722 Gag-Pol polyprotein gag-pol 0.005
6306 Gag-Pol polyprotein gag-pol 0.005
6624 Gag-Pol polyprotein gag-pol 0.005
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0049
229 Retinoic acid receptor beta RARB 0.0049
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
6174 50S ribosomal protein L32 rpmF 0.0049
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0049
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0049
3231 Death-associated protein kinase 1 DAPK1 0.0049
518 Peroxidase/catalase T katG 0.0048
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0048
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0048
730 Retinoic acid receptor alpha RARA 0.0048
2540 Choloylglycine hydrolase cbh 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
2417 Chloramphenicol acetyltransferase cat 0.0047
3278 Chloramphenicol acetyltransferase cat 0.0047
378 Alpha-2C adrenergic receptor ADRA2C 0.0047
958 Insulin-like growth factor 1 receptor IGF1R 0.0047
2810 Dr hemagglutinin structural subunit draA 0.0047
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0047
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0046
128 Adenine phosphoribosyltransferase APRT 0.0046
1992 Vitamin D-binding protein GC 0.0046
887 DNA gyrase subunit B gyrB 0.0046
4150 DNA gyrase subunit B gyrB 0.0046
6225 DNA gyrase subunit B gyrB 0.0046
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0046
2427 Ferrichrome-iron receptor fhuA 0.0045
2693 Heat-labile enterotoxin B chain eltB 0.0044
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0044
84 Nuclear receptor 0B1 NR0B1 0.0044
432 D(4) dopamine receptor DRD4 0.0044
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0044
517 Alcohol dehydrogenase 1C ADH1C 0.0043
6645 D-amino-acid oxidase DAO 0.0043
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0043
751 Potassium channel subfamily K member 6 KCNK6 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
4606 Purine trans deoxyribosylase ptd 0.0042
239 Coagulation factor X F10 0.0042
6432 Transporter snf 0.0042
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0042
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0041
2300 Lysozyme E 0.0041
3633 Lysozyme R 0.0041
5597 Lysozyme 17 0.0041
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.004
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.004
6212 Tubulin gamma-1 chain TUBG1 0.004
6210 Tubulin delta chain TUBD1 0.004
6211 Tubulin epsilon chain TUBE1 0.004
775 Acetyl-CoA carboxylase 2 ACACB 0.004
818 50S ribosomal protein L10 rplJ 0.0039
172 Potassium channel subfamily K member 1 KCNK1 0.0039
6168 Solute carrier family 22 member 16 SLC22A16 0.0039
2408 Tyrosine-protein kinase SYK SYK 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
3830 Calreticulin CALR 0.0038
1178 Adenosine A2a receptor ADORA2A 0.0038
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
1864 RET proto-oncogene RET 0.0037
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0036
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0036
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0036
760 Fibroblast growth factor 1 FGF1 0.0036
5682 Ribonuclease pancreatic RNASE1 0.0036
595 Fibrinogen alpha chain FGA 0.0036
208 DNA-directed RNA polymerase beta' chain rpoC 0.0036
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0036
6034 Hydroxyindole O-methyltransferase ASMT 0.0035
6035 Nuclear receptor ROR-beta RORB 0.0035
997 Protein kinase C beta type PRKCB 0.0035
6036 Eosinophil peroxidase EPX 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
1836 Mitogen-activated protein kinase 10 MAPK10 0.0034
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0034
4311 tRNA TRDMT1 0.0033
4325 tRNA trmD 0.0033
4328 tRNA trmD 0.0033
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
2499 Tubulin beta-2C chain TUBB2C 0.0031
1525 Heparin-binding growth factor 2 FGF2 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0031
765 Indoleamine 2,3-dioxygenase IDO1 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0031
5287 Signaling protein Not Available 0.003
5288 Shikimate kinase aroK 0.003
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.003
5304 UPF0166 protein TM_0021 TM_0021 0.003
3199 Phosphopantetheine adenylyltransferase coaD 0.003
3543 Phosphopantetheine adenylyltransferase coaD 0.003
3567 Phosphopantetheine adenylyltransferase coaD 0.003
5289 Phosphopantetheine adenylyltransferase coaD 0.003
4346 Polynucleotide kinase pseT 0.003
5293 Shikimate kinase 2 aroL 0.003
896 Glutathione S-transferase Mu 1 GSTM1 0.003
5283 D-alanine--D-alanine ligase B ddlB 0.003
5281 Plasmid segregation protein parM parM 0.003
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.003
5292 Putative partitioning protein TT_C1605 0.003
5276 Chromosomal replication initiator protein dnaA dnaA 0.003
5266 Activator of hgdC 0.003
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.003
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.003
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.003
2874 Nitrogenase iron protein 1 nifH1 0.003
5299 D-alanine--D-alanine ligase ddl 0.003
6598 D-alanine--D-alanine ligase ddl 0.003
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.003
1549 Heat shock 70 kDa protein 1 HSPA1A 0.003
5308 Preprotein translocase secA 1 subunit secA1 0.003
5259 Transcriptional regulator ntrC1 0.003
6699 Transcriptional regulator Cgl2612 0.003
5284 Large T antigen Not Available 0.003
5291 Glycogen synthase 1 glgA1 0.003
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.003
5264 DNA replication protein REP 0.003
5277 Preprotein translocase subunit secA secA 0.003
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.003
5285 Kinesin heavy chain KIF5B 0.003
5315 Chaperone protein htpG htpG 0.003
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.003
5261 Phosphoribosylformylglycinamidine synthase purL 0.003
654 Flavin reductase BLVRB 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
683 Potassium transporter GK0582 0.0029
1374 Natriuretic peptides B NPPB 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
1827 Gap junction alpha-1 protein GJA1 0.0029
1908 Vascular cell adhesion protein 1 VCAM1 0.0029
581 Cytochrome P450 2R1 CYP2R1 0.0028
16 Adenosine A1 receptor ADORA1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
174 Sigma 1-type opioid receptor SIGMAR1 0.0028
2112 Toll-like receptor 9 TLR9 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
2697 Uridine-cytidine kinase 2 UCK2 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0027
5126 Arginase rocF 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1025 Aquaporin-1 AQP1 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
1256 5-hydroxytryptamine 6 receptor HTR6 0.0027
340 Apoptotic protease-activating factor 1 APAF1 0.0027
163 D(1B) dopamine receptor DRD5 0.0026
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0026
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0026
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0026
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0026
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0026
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0026
153 Dopamine beta-hydroxylase DBH 0.0026
85 Growth hormone receptor GHR 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
3470 Hypothetical protein MG245 homolog MPN_348 0.0025
6277 Heat shock cognate 71 kDa protein HSPA8 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
3426 Glutamine synthetase glnA 0.0025
3987 Glutamine synthetase GLUL 0.0025
3175 Glutamate--cysteine ligase gshA 0.0025
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0025
5189 Trimethylamine dehydrogenase tmd 0.0025
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0025
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0025
4106 Guanylate kinase GUK1 0.0025
4516 Guanylate kinase gmk 0.0025
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0024
2270 Dephospho-CoA kinase coaE 0.0024
4837 Cag-alfa cag-alfa 0.0024
4774 NTPase P4 Not Available 0.0024
4838 PMS1 protein homolog 2 PMS2 0.0024
2284 Adenylate kinase adk 0.0024
2296 Adenylate kinase adk 0.0024
2311 Adenylate kinase adk 0.0024
2312 Adenylate kinase Not Available 0.0024
4839 DNA polymerase III subunit tau dnaX 0.0024
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0024
3814 Complement C1r subcomponent C1R 0.0024
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
4992 Cytochrome c peroxidase Not Available 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
3611 Cytidine deaminase cdd 0.0024
3707 Cytidine deaminase cdd 0.0024
4211 Cytidine deaminase CDA 0.0024
6231 Pepsin A PGA3 0.0024
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0024
605 Fumarate reductase flavoprotein subunit frdA 0.0024
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0024
3673 Fumarate reductase flavoprotein subunit fccA 0.0024
4912 Fumarate reductase flavoprotein subunit ifcA 0.0024
6549 Fumarate reductase flavoprotein subunit frdA 0.0024
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0023
6824 Tyrosine-protein kinase Lyn LYN 0.0023
2683 Mono-ADP-ribosyltransferase C3 C3 0.0023
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
563 Thyroid peroxidase TPO 0.0022
2782 Complement C1s subcomponent C1S 0.0022
4034 Glutaredoxin-1 GLRX 0.0022
1928 Leukotriene C4 synthase LTC4S 0.0022
5271 Focal adhesion kinase 1 PTK2 0.0022
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0022
910 Epididymal secretory glutathione peroxidase GPX5 0.0022
4036 Glutathione peroxidase 6 GPX6 0.0022
4037 Hypothetical protein GPX1 0.0022
4297 Hypothetical protein SP_1951 0.0022
4521 Hypothetical protein BC_2969 0.0022
4540 Hypothetical protein TM_1070 0.0022
4555 Hypothetical protein MT1739 0.0022
4569 Hypothetical protein mshD 0.0022
4578 Hypothetical protein PA3270 0.0022
4747 Hypothetical protein PA3967 0.0022
5177 Hypothetical protein TM_0096 0.0022
5194 Hypothetical protein PA1204 0.0022
5240 Hypothetical protein Rv2991 0.0022
5370 Hypothetical protein TM_1158 0.0022
5710 Hypothetical protein Tb927.5.1360 0.0022
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0022
4029 Microsomal glutathione S-transferase 3 MGST3 0.0022
911 Glutathione peroxidase 3 GPX3 0.0022
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0022
903 Glutathione S-transferase A5 GSTA5 0.0022
4032 Microsomal glutathione S-transferase 1 MGST1 0.0022
4040 Glutathione peroxidase 7 GPX7 0.0022
907 Glutathione peroxidase 2 GPX2 0.0022
900 Glutathione S-transferase A4 GSTA4 0.0022
906 Glutathione peroxidase 1 GPX1 0.0022
4035 Glutathione S-transferase Mu 5 GSTM5 0.0022
4042 Glutathione transferase omega-2 GSTO2 0.0022
4033 S-formylglutathione hydrolase ESD 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
4038 Glutathione peroxidase 4 GPX4 0.0022
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0022
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0022
2390 Nonsecretory ribonuclease RNASE2 0.0022
814 Ryanodine receptor 1 RYR1 0.0022
2922 Glycerol kinase glpK 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
3086 Plasmepsin-2 Not Available 0.0022
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0021
1262 Corticotropin-lipotropin POMC 0.0021
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0021
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0021
2282 Protein recA recA 0.0021
2315 Protein recA recA 0.0021
2332 Protein recA recA 0.0021
5263 Protein recA recA 0.0021
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0021
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0021
164 Histamine H4 receptor HRH4 0.0021
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
3913 Glutamic acid decarboxylase GAD65 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
3669 Ribokinase rbsK 0.002
1123 Eosinophil cationic protein RNASE3 0.002
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
3090 Chitosanase csn 0.002
3319 Hydroxyacylglutathione hydrolase HAGH 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
76 Nitric-oxide synthase, brain NOS1 0.002
897 Glutathione S-transferase kappa 1 GSTK1 0.002
898 Glutathione S-transferase A3 GSTA3 0.002
6048 Troponin C, skeletal muscle TNNC2 0.002
564 Cellular retinoic acid-binding protein 1 CRABP1 0.002
856 Vitamin D3 receptor VDR 0.002
909 Maleylacetoacetate isomerase GSTZ1 0.002
788 Creatine kinase M-type CKM 0.002
6163 Copper-transporting ATPase 2 ATP7B 0.002
6165 Copper-transporting ATPase 1 ATP7A 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.002
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
899 Glutathione S-transferase Mu 3 GSTM3 0.0019
905 Glutathione transferase omega-1 GSTO1 0.0019
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0019
1483 Membrane copper amine oxidase AOC3 0.0019
4041 Microsomal glutathione S-transferase 2 MGST2 0.0019
2334 Dethiobiotin synthetase bioD 0.0019
6555 Dethiobiotin synthetase bioD 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0019
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0018
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0018
1253 Interferon gamma IFNG 0.0018
3221 Cytochrome c4 cc4 0.0018
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0018
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0018
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0018
48 Pyridoxal kinase PDXK 0.0018
2165 Glutathione S-transferase Mu 2 GSTM2 0.0018
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
4948 Cytochrome c-553 Not Available 0.0017
4923 Cytochrome c3 DvMF_2499 0.0017
4945 Cytochrome c3 Not Available 0.0017
4949 Cytochrome c3 DVU_3171 0.0017
4968 Cytochrome c3 cytc3 0.0017
4997 Cytochrome c3 SO_2727 0.0017
5219 Cytochrome c3 cyd 0.0017
3189 High-molecular-weight cytochrome c hmcA 0.0017
4902 Nine-heme cytochrome c Ddes_2038 0.0017
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0017
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0017
735 Alanine aminotransferase 1 GPT 0.0017
3904 Alanine aminotransferase 2 GPT2 0.0017
6395 Myosin-14 MYH14 0.0017
2091 Endoplasmin HSP90B1 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
901 Glutathione S-transferase Mu 4 GSTM4 0.0017
1422 Serine/threonine-protein kinase 6 AURKA 0.0016
3379 Kinesin-like protein KIF11 KIF11 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0016
2216 Fibroblast growth factor receptor 4 FGFR4 0.0016
444 Alcohol dehydrogenase 1B ADH1B 0.0016
4943 Cytochrome c6 petJ 0.0015
4954 Soluble cytochrome b558 Not Available 0.0015
4947 Bacterial hemoglobin vhb 0.0015
4934 Cytochrome c-551 nirM 0.0015
5218 Cytochrome c-551 nirM 0.0015
4905 Cytochrome c2 Not Available 0.0015
4939 Cytochrome c2 cycA 0.0015
4964 Cytochrome c2 cycA 0.0015
4979 Cytochrome c2 cycA 0.0015
6673 Cytochrome c2 cycA 0.0015
4916 Cyanoglobin glbN 0.0015
4984 Neuroglobin NGB 0.0015
4925 Cytochrome c-type protein SHP shp 0.0015
4994 Hemoglobin-like protein HbO glbO 0.0015
4942 Diheme cytochrome c napB napB 0.0015
4915 Cytochrome c-550 psbV 0.0015
4959 Cytochrome c-550 psbV 0.0015
5216 Cytochrome c-550 psbV 0.0015
4975 Cytochrome c-556 RPA3973 0.0015
4998 Hemoglobin-like protein yjbI yjbI 0.0015
4936 Cytochrome c2 iso-2 Not Available 0.0015
4961 Hemophore HasA hasA 0.0015
5000 HemO hemO 0.0015
4981 Iron-starvation protein PigA pigA 0.0015
4910 Cytoglobin CYGB 0.0015
644 Heme oxygenase 2 HMOX2 0.0015
4982 Heme oxygenase 2 pbsA2 0.0015
4909 CooA protein cooA 0.0015
4904 Cytochrome c family protein GSU1996 0.0015
4935 Cytochrome c-554 cycA1 0.0015
4907 Cytochrome c-L moxG 0.0015
6865 Cytochrome c-L moxG 0.0015
4971 Nonaheme cytochrome c hmcA 0.0015
4976 Apocytochrome f petA 0.0015
6407 Apocytochrome f petA 0.0015
4937 Cytochrome oxidase subunit II rcoxA 0.0015
4989 Cytochrome c551 peroxidase ccp 0.0015
5222 Cytochrome c551 peroxidase ccpA 0.0015
4764 Cytochrome P450 165C4 CYP165C4 0.0015
4999 Cytochrome P450 165B3 CYP165B3 0.0015
4931 Cytochrome P450 167A1 CYP167A1 0.0015
4926 Heme-based aerotactic transducer hemAT hemAT 0.0015
4960 Putative cytochrome P450-family protein SCO7417 0.0015
4972 P450cin cinA 0.0015
4903 Methyl-accepting chemotaxis protein Tar4 0.0015
4922 Cytochrome c, putative SO_4144 0.0015
4993 Hydroxylamine oxidoreductase hao1 0.0015
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0015
4952 Catalase/peroxidase katA 0.0015
3093 Catalase HPII katE 0.0015
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0015
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0015
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0015
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0015
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0015
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0015
4031 Glutathione S-transferase A1 GSTA1 0.0015
4386 Hemoglobin-like protein HbN glbN 0.0015
714 Glutathione reductase, mitochondrial GSR 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
2129 Sucrase-isomaltase, intestinal SI 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
233 Potassium channel subfamily K member 2 KCNK2 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
251 Alcohol dehydrogenase 1A ADH1A 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
2232 Interleukin-5 IL5 0.0014
1593 Mucin-2 MUC2 0.0014
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0013
1268 Neuropeptide S receptor NPSR1 0.0013
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0013
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0013
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0013
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0013
820 Glycine receptor subunit alpha-2 GLRA2 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
569 Retinal dehydrogenase 2 ALDH1A2 0.0012
5590 N utilization substance protein B homolog nusB 0.0012
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0012
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0012
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0012
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0012
2838 Ribose-5-phosphate isomerase A rpiA 0.0012
2952 Ribose-5-phosphate isomerase A rpiA 0.0012
5595 Ribose-5-phosphate isomerase A rpiA 0.0012
4695 UPF0124 protein yfiH yfiH 0.0012
5060 Intron-associated endonuclease 1 ITEVIR 0.0012
5593 Transferase Not Available 0.0012
5588 Cell division protein FtsY TM_0570 0.0012
5591 Complement component C8 gamma chain C8G 0.0012
5587 Iron(III)-binding periplasmic protein fbpA 0.0012
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0012
5582 Regulator of transcription; stringent starvation protein A sspA 0.0012
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0012
5581 Beta-fructosidase bfrA 0.0012
5600 Pyruvate decarboxylase pdc 0.0012
4375 Glutamine synthetase 1 glnA1 0.0012
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0012
5575 Short tail fiber protein 12 0.0012
5580 Hexon protein PII 0.0012
5574 Invasin YPTB1668 0.0012
694 Matrix protein 2 M 0.0012
6073 Potassium channel subfamily K member 9 KCNK9 0.0012
6072 Potassium channel subfamily K member 3 KCNK3 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
6859 Protein S100-A4 S100A4 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
4920 Peroxidase/catalase katG 0.0012
611 Retinal dehydrogenase 1 ALDH1A1 0.0012
2119 Cytochrome b5 CYB5A 0.0011
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0011
4990 PpcA ppcA 0.0011
4289 Cytochrome P450 TT_P0059 0.0011
6262 Cytochrome P450 staP 0.0011
3570 Cytochrome P450 152A1 cypC 0.0011
4988 Sulfite oxidase, mitochondrial SUOX 0.0011
3375 Acidic cytochrome c3 Not Available 0.0011
2915 Sensor protein fixL fixL 0.0011
4944 Sensor protein fixL fixL 0.0011
4385 Cytochrome c' Not Available 0.0011
4967 Cytochrome c' cycA 0.0011
5038 Cytochrome c' Not Available 0.0011
5223 Cytochrome c' cycP 0.0011
4813 Heme oxygenase hmuO 0.0011
5769 Heme oxygenase Not Available 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
2230 Catalase CAT 0.0011
3249 Catalase katA 0.0011
3625 Catalase katA 0.0011
4539 Catalase katA 0.0011
4941 Catalase katB 0.0011
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
5006 RNASE4 protein RNASE4 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
5328 Prostaglandin F synthase Tb11.02.2310 0.0011
131 Synaptic vesicular amine transporter SLC18A2 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
3729 Citrate synthase gltA 0.0011
4575 Citrate synthase cit 0.0011
4580 Citrate synthase gltA 0.0011
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
3670 Soluble cytochrome b562 precursor cybC 0.001
3411 Cytochrome P450 121 cyp121 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
2617 Nitric oxide synthase oxygenase nos 0.001
2701 Nitric oxide synthase oxygenase nos 0.001
3291 Cytochrome c-552 cycA 0.001
4927 Cytochrome c-552 nrfA 0.001
4938 Cytochrome c-552 cycA 0.001
4953 Cytochrome c-552 nrfA 0.001
5217 Cytochrome c-552 cycM 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
2603 Beta-lactamase II blm 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
3102 Flavohemoprotein hmp 0.001
4969 Flavohemoprotein hmp 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2149 Angiogenin ANG 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
3583 6-phosphogluconolactonase pgl 0.001
857 Malate dehydrogenase, mitochondrial MDH2 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
1360 Sphingomyelin phosphodiesterase SMPD1 0.0009
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
2942 Sialidase nanH 0.0009
3546 Sialidase nedA 0.0009
3486 Fumarate hydratase class II fumC 0.0009
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0009
2286 Isocitrate dehydrogenase [NADP] icd 0.0009
2302 Isocitrate dehydrogenase [NADP] icd 0.0009
2771 Isocitrate dehydrogenase [NADP] icd 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
1341 Histamine H3 receptor HRH3 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
2972 6-deoxyerythronolide B hydroxylase eryF 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0009
411 Glycine N-methyltransferase GNMT 0.0009
1184 Interferon beta IFNB1 0.0008
4608 Putative cytochrome P450 SCO1207 0.0008
4963 Putative cytochrome P450 SCO2884 0.0008
6254 Putative cytochrome P450 SCO6998 0.0008
5579 Carboxypeptidase B CPB1 0.0008
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
358 Cystathionine beta-synthase CBS 0.0008
693 Hemoglobin subunit beta HBB 0.0008
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
6268 Hydroxyacid oxidase 1 HAO1 0.0007
810 Heme oxygenase 1 HMOX1 0.0007
3391 Heme oxygenase 1 pbsA1 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
2298 Cytochrome P450-cam camC 0.0006
2802 Endoglucanase G celCCG 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2430 Chondroitinase B cslB 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
6021 Adenosine kinase ADK 0.0002
2440 Endoglucanase F celCCF 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
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