DT-Web

DB00275 - Olmesartan


Identification
Name Olmesartan
Accession Number DB00275 (APRD00223)
Type small molecule
Description Olmesartan is an antihypertensive agent, which belongs to the class of medications called angiotensin II receptor blockers. It is indicated for the treatment of high blood pressure and is marketed under the name Olmetec(R). The FDA label includes a black-box warning of injury and death to the fetus, so women of child-bearing age need to be warned and take the necessary precautions. Olmesartan is also contraindicated in diabetes mellitus patients taking aliskiren.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 446.5016
Groups approved
Monoisotopic Weight 446.206638728
Pharmacology
Indication For the treatment of hypertension.
Mechanism of action Olmesartan is an ARB that selectively inhibits the binding of angiotensin II to AT1, which is found in many tissues such as vascular smooth muscle and the adrenal glands. This effectively inhibits the AT1-mediated vasoconstrictive and aldosterone-secreting effects of angiotensin II and results in a decrease in vascular resistance and blood pressure. Olmesartan is selective for AT1 and has a 12,500 times greater affinity for AT1 than the AT2 receptor. Also unlike the well-known ARB losartan, olmesartan does not have an active metabolite or possess uricosuric effects.
Absorption Bioavailability is about 26%. Food does not affect the bioavailability of olmesartan.
Protein binding Highly bound to plasma proteins (99%) and does not penetrate red blood cells.
Biotransformation Olmesartan is rapidly and completely bioactivated by ester hydrolysis to olmesartan during absorption from the gastrointestinal tract. There is virtually no further metabolism of olmesartan.
Route of elimination Olmesartan is elminated unchanged in the urine (35% to 50%) and the remainder in the feces.
Toxicity The main symptoms of overdose include low blood pressure and fast heartbeat.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Drospirenone Increased risk of hyperkalemia
Tobramycin Increased risk of nephrotoxicity
Trandolapril The angiotensin II receptor blocker, Olmesartan, may increase the adverse effects of Trandolapril.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Food Interactions
  • Food does not affect the bioavailability of olmesartan.

Targets


Type-1 angiotensin II receptor
Name Type-1 angiotensin II receptor
Gene Name AGTR1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Koike H, Sada T, Mizuno M: In vitro and in vivo pharmacology of olmesartan medoxomil, an angiotensin II type AT1 receptor antagonist. J Hypertens Suppl. 2001 Jun;19(1):S3-14. - Pubmed
  • Ochiai K, Hu Q, Lee J, Mansoor A, Liu J, Wang X, Gong G, Murakami Y, Ishibashi Y, Shimada T, Zhang J: Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling. J Cardiovasc Pharmacol. 2006 May;47(5):686-94. - Pubmed
  • Warner GT, Jarvis B: Olmesartan medoxomil. Drugs. 2002;62(9):1345-53; discussion 1354-6. - Pubmed
  • Mire DE, Silfani TN, Pugsley MK: A review of the structural and functional features of olmesartan medoxomil, an angiotensin receptor blocker. J Cardiovasc Pharmacol. 2005 Nov;46(5):585-93. - Pubmed
  • Kreutz R, Bolbrinker J, Huber M: Pharmacokinetics of olmesartan medoxomil plus hydrochlorothiazide combination in healthy subjects. Clin Drug Investig. 2006;26(1):29-34. - Pubmed
DTHybrid score 0.7148

Transporters


Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate,inducer
References
  • Weiss J, Sauer A, Divac N, Herzog M, Schwedhelm E, Boger RH, Haefeli WE, Benndorf RA: Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters. Biopharm Drug Dispos. 2010 Mar;31(2-3):150-61. - Pubmed
  • Nakagomi-Hagihara R, Nakai D, Kawai K, Yoshigae Y, Tokui T, Abe T, Ikeda T: OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker. Drug Metab Dispos. 2006 May;34(5):862-9. Epub 2006 Feb 24. - Pubmed
DTHybrid score 0.2565
Solute carrier organic anion transporter family member 1B3
Name Solute carrier organic anion transporter family member 1B3
Gene Name SLCO1B3
Actions substrate
References
  • Nakagomi-Hagihara R, Nakai D, Kawai K, Yoshigae Y, Tokui T, Abe T, Ikeda T: OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker. Drug Metab Dispos. 2006 May;34(5):862-9. Epub 2006 Feb 24. - Pubmed
DTHybrid score 0.2518
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions substrate
References
  • Nakagomi-Hagihara R, Nakai D, Kawai K, Yoshigae Y, Tokui T, Abe T, Ikeda T: OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker. Drug Metab Dispos. 2006 May;34(5):862-9. Epub 2006 Feb 24. - Pubmed
DTHybrid score 0.3192

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.1339
4512 Cytochrome P450 3A4 CYP3A4 0.1086
4757 Cytochrome P450 2C9 CYP2C9 0.1073
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.092
4924 Cytochrome P450 2C8 CYP2C8 0.0919
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0915
5852 Type-2 angiotensin II receptor AGTR2 0.0627
587 Serum albumin ALB 0.0613
4118 Cytochrome P450 3A5 CYP3A5 0.0601
6016 Cytochrome P450 2C19 CYP2C19 0.0598
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0576
862 Multidrug resistance-associated protein 1 ABCC1 0.0534
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0508
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0499
4200 Cytochrome P450 1A2 CYP1A2 0.048
1729 Solute carrier family 22 member 6 SLC22A6 0.0475
2164 Multidrug resistance-associated protein 4 ABCC4 0.0468
6142 Solute carrier family 22 member 8 SLC22A8 0.0456
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0441
776 Bile salt export pump ABCB11 0.0441
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0409
4119 Cytochrome P450 2D6 CYP2D6 0.0405
6107 Cytochrome P450 3A7 CYP3A7 0.0375
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0357
3587 Gastrotropin FABP6 0.0353
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.035
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0344
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.034
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.034
20 Prostaglandin G/H synthase 1 PTGS1 0.0338
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.033
6141 Sodium/bile acid cotransporter SLC10A1 0.0328
6030 Cytochrome P450 2B6 CYP2B6 0.0319
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0301
6145 Solute carrier family 22 member 1 SLC22A1 0.0273
6148 Multidrug resistance-associated protein 7 ABCC10 0.0255
6024 Cytochrome P450 1A1 CYP1A1 0.0206
758 Thyroid hormone receptor alpha THRA 0.0201
6143 Solute carrier family 22 member 7 SLC22A7 0.0194
1024 Solute carrier family 22 member 11 SLC22A11 0.0191
1629 Transcription factor AP-1 JUN 0.0187
118 Organic cation/carnitine transporter 2 SLC22A5 0.018
346 Thyroid hormone receptor beta-1 THRB 0.018
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0177
29 Tubulin beta-1 chain TUBB1 0.0177
594 Thyroxine-binding globulin SERPINA7 0.0174
6167 Organic solute transporter subunit beta OSTB 0.0164
6166 Organic solute transporter subunit alpha OSTA 0.0164
13 Aminomethyltransferase, mitochondrial AMT 0.0154
1898 Cytochrome P450 1B1 CYP1B1 0.0152
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.015
6144 Solute carrier family 22 member 2 SLC22A2 0.0147
738 Monocarboxylate transporter 1 SLC16A1 0.0147
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0138
136 Estrogen receptor ESR1 0.0136
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0134
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0133
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0131
4604 Liver carboxylesterase 1 CES1 0.013
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0122
2539 Tubulin alpha-1 chain TUBA4A 0.0119
6013 Cytochrome P450 2E1 CYP2E1 0.0119
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0118
6136 Multidrug resistance-associated protein 5 ABCC5 0.0115
33 Cystine/glutamate transporter SLC7A11 0.0114
477 DNA topoisomerase 4 subunit A parC 0.0113
886 DNA topoisomerase 4 subunit A parC 0.0113
6226 DNA topoisomerase 4 subunit A parC 0.0113
275 Arachidonate 5-lipoxygenase ALOX5 0.0112
404 DNA gyrase subunit A gyrA 0.0111
6224 DNA gyrase subunit A gyrA 0.0111
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0111
373 Transthyretin TTR 0.0111
1181 Alpha-1-acid glycoprotein 1 ORM1 0.011
817 DNA topoisomerase 2-alpha TOP2A 0.0109
731 HIV-1 protease HIV-1 protease 0.0109
2443 Azurin azu 0.0108
5923 Microtubule-associated protein tau MAPT 0.0107
5924 Microtubule-associated protein 4 MAP4 0.0107
833 Organic cation/carnitine transporter 1 SLC22A4 0.0107
1852 Microtubule-associated protein 2 MAP2 0.0099
199 Monocarboxylate transporter 8 SLC16A2 0.0098
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0097
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0096
273 Apoptosis regulator Bcl-2 BCL2 0.0093
6137 Multidrug resistance-associated protein 6 ABCC6 0.0089
26 Vascular endothelial growth factor receptor 3 FLT4 0.0085
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0084
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0084
850 Vasopressin V1b receptor AVPR1B 0.0081
32 Vascular endothelial growth factor receptor 1 FLT1 0.0081
5880 Thrombopoietin receptor MPL 0.0081
24 Thymidylate synthase TMP1 0.0077
359 Thymidylate synthase TYMS 0.0077
2626 Thymidylate synthase thyA 0.0077
2729 Thymidylate synthase thyA 0.0077
5352 Thymidylate synthase THYA 0.0077
6147 Solute carrier family 22 member 3 SLC22A3 0.0076
468 Cytochrome P450 4A11 CYP4A11 0.0075
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0075
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0073
185 Vasopressin V1a receptor AVPR1A 0.0071
2417 Chloramphenicol acetyltransferase cat 0.0071
3278 Chloramphenicol acetyltransferase cat 0.0071
5718 Cytochrome P450 2A6 CYP2A6 0.0071
6151 Monocarboxylate transporter 10 SLC16A10 0.0071
492 Histamine H1 receptor HRH1 0.007
322 Vasopressin V2 receptor AVPR2 0.007
407 Vascular endothelial growth factor receptor 2 KDR 0.0066
3811 Cytochrome P450 19A1 CYP19A1 0.0066
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0065
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0064
614 Progesterone receptor PGR 0.0064
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0063
1650 Heme carrier protein 1 SLC46A1 0.0062
3270 Elongation factor G fusA 0.0062
2808 Chloramphenicol acetyltransferase 3 cat3 0.0061
908 Glutathione S-transferase theta-1 GSTT1 0.006
6149 Solute carrier family 22 member 10 SLC22A10 0.0059
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0057
1760 Aminopeptidase N ANPEP 0.0057
6843 Aminopeptidase N pepN 0.0057
3947 Xanthine dehydrogenase/oxidase XDH 0.0056
117 Sterol O-acyltransferase 1 SOAT1 0.0055
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0055
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0053
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0053
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0052
1757 Myeloperoxidase MPO 0.005
5818 Folate receptor alpha FOLR1 0.005
6220 Aryl hydrocarbon receptor AHR 0.0049
2391 Ferrochelatase hemH 0.0049
6502 Ferrochelatase DKFZp686P18130 0.0049
1591 Ferrochelatase, mitochondrial FECH 0.0049
6085 Fatty acid-binding protein, intestinal FABP2 0.0049
5626 Nucleoside diphosphate kinase B NME2 0.0048
904 Glutathione S-transferase P GSTP1 0.0047
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0047
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0047
6163 Copper-transporting ATPase 2 ATP7B 0.0046
6165 Copper-transporting ATPase 1 ATP7A 0.0046
3809 Estrogen-related receptor gamma ESRRG 0.0045
228 Beta platelet-derived growth factor receptor PDGFRB 0.0045
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0044
1630 Integrin beta-2 ITGB2 0.0044
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0044
6146 High affinity copper uptake protein 1 SLC31A1 0.0044
284 DNA-directed RNA polymerase beta chain rpoB 0.0043
5773 DNA-directed RNA polymerase beta chain rpoB 0.0043
293 Gamma-glutamyl hydrolase GGH 0.0043
3917 Methylenetetrahydrofolate reductase MTHFR 0.0043
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0043
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0043
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0043
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0043
6493 Cytochrome c oxidase subunit 6C COX6C 0.0043
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0043
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0043
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0043
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0043
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0043
6559 Cytochrome c oxidase subunit 2 ctaC 0.0043
6669 Cytochrome c oxidase subunit 2 ctaC 0.0043
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0043
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0043
6558 Cytochrome c oxidase subunit 1 ctaD 0.0043
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0042
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0042
6031 Cytochrome P450 3A43 CYP3A43 0.0042
504 Mast/stem cell growth factor receptor KIT 0.0042
896 Glutathione S-transferase Mu 1 GSTM1 0.0042
1502 Peroxisome proliferator-activated receptor delta PPARD 0.004
5294 Nucleoside diphosphate kinase A NME1 0.0039
2540 Choloylglycine hydrolase cbh 0.0039
563 Thyroid peroxidase TPO 0.0038
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0038
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0038
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0037
6501 Fatty acid-binding protein, liver FABP1 0.0037
6168 Solute carrier family 22 member 16 SLC22A16 0.0036
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0036
6044 Serum paraoxonase/lactonase 3 PON3 0.0036
3810 Catechol O-methyltransferase COMT 0.0036
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
4148 Serine/threonine-protein kinase mTOR MTOR 0.0035
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0034
511 5-hydroxytryptamine 1F receptor HTR1F 0.0034
290 Prostaglandin G/H synthase 2 PTGS2 0.0034
952 Dipeptidyl peptidase 4 DPP4 0.0033
572 Integrin alpha-L ITGAL 0.0033
1525 Heparin-binding growth factor 2 FGF2 0.0033
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0033
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0033
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0033
1353 DNA topoisomerase 1 TOP1 0.0032
3552 DNA topoisomerase 1 topA 0.0032
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
131 Synaptic vesicular amine transporter SLC18A2 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
6500 Phospholipase A2 PLA2G1B 0.003
4122 Histone deacetylase 2 HDAC2 0.003
737 Mineralocorticoid receptor NR3C2 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
165 FL cytokine receptor FLT3 0.0029
6020 Aldehyde oxidase AOX1 0.0029
869 Estrogen receptor beta ESR2 0.0029
768 FK506-binding protein 1A FKBP1A 0.0029
777 Tumor necrosis factor TNF 0.0028
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0028
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0028
4192 DNA topoisomerase 2-beta TOP2B 0.0028
6106 Cytochrome P450 2C18 CYP2C18 0.0028
751 Potassium channel subfamily K member 6 KCNK6 0.0028
365 Dihydrofolate reductase DHFR 0.0028
2381 Dihydrofolate reductase DFR1 0.0028
2833 Dihydrofolate reductase Not Available 0.0028
2931 Dihydrofolate reductase folA 0.0028
3544 Dihydrofolate reductase folA 0.0028
3682 Dihydrofolate reductase folA 0.0028
6642 Dihydrofolate reductase folA 0.0028
6756 Dihydrofolate reductase dfrA 0.0028
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0027
517 Alcohol dehydrogenase 1C ADH1C 0.0027
1569 G1/S-specific cyclin-D1 CCND1 0.0027
3923 Cholinesterase BCHE 0.0026
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0026
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0025
551 Carnitine O-acetyltransferase CRAT 0.0025
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0025
172 Potassium channel subfamily K member 1 KCNK1 0.0025
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0025
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0025
3856 Fibroblast growth factor receptor 3 FGFR3 0.0025
725 5-hydroxytryptamine 1D receptor HTR1D 0.0024
885 5-hydroxytryptamine 1B receptor HTR1B 0.0024
756 Sex hormone-binding globulin SHBG 0.0024
6211 Tubulin epsilon chain TUBE1 0.0024
6210 Tubulin delta chain TUBD1 0.0024
6212 Tubulin gamma-1 chain TUBG1 0.0024
146 Androgen receptor AR 0.0024
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0024
3941 Amine oxidase [flavin-containing] A MAOA 0.0024
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0023
320 5-hydroxytryptamine 1A receptor HTR1A 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0021
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0021
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0021
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0021
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
4120 NADPH--cytochrome P450 reductase POR 0.002
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.002
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.002
489 Monocarboxylate transporter 2 SLC16A7 0.002
132 ATP-binding cassette sub-family A member 1 ABCA1 0.002
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0019
6837 Serine/threonine-protein kinase 17B STK17B 0.0019
342 P protein [Includes: DNA-directed DNA polymerase P 0.0018
612 P protein [Includes: DNA-directed DNA polymerase P 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0018
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0018
1176 Mitogen-activated protein kinase 1 MAPK1 0.0018
267 Plasminogen activator inhibitor 1 SERPINE1 0.0017
2449 Tubulin alpha-3 chain TUBA1A 0.0017
760 Fibroblast growth factor 1 FGF1 0.0017
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0017
6221 Steroid hormone receptor ERR1 ESRRA 0.0016
702 UMP-CMP kinase CMPK1 0.0016
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
6599 HTH-type transcriptional regulator ttgR ttgR 0.0015
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0015
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0015
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0015
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0015
2599 Tyrosine-protein kinase HCK HCK 0.0015
357 Carbonic anhydrase 2 CA2 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0014
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0014
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0014
1313 Lactoylglutathione lyase GLO1 0.0014
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0014
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0014
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0014
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0014
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
4773 Deoxycytidine kinase DCK 0.0013
7 Nitric oxide synthase, inducible NOS2 0.0013
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0013
6218 Pannexin-1 PANX1 0.0013
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0013
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0012
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0012
260 Cytochrome P450 51 ERG11 0.0011
761 Cytochrome P450 51 ERG11 0.0011
3163 Cytochrome P450 51 cyp51 0.0011
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0011
6042 Prostaglandin reductase 2 PTGR2 0.0011
340 Apoptotic protease-activating factor 1 APAF1 0.0011
84 Nuclear receptor 0B1 NR0B1 0.0011
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0011
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0011
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0011
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.0011
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.001
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.001
469 Annexin A1 ANXA1 0.001
6043 Putative G-protein coupled receptor 44 GPR44 0.001
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.001
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.001
825 Arsenical pump-driving ATPase ASNA1 0.001
3435 Arsenical pump-driving ATPase arsA 0.001
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.001
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.001
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.001
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.001
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.001
733 Activin receptor type 1B ACVR1B 0.001
154 AFG3-like protein 2 AFG3L2 0.001
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.001
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.001
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.001
395 ALK tyrosine kinase receptor Not Available 0.001
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.001
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.001
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0009
824 Sodium-dependent serotonin transporter SLC6A4 0.0009
292 Activin receptor type-1 ACVR1 0.0009
849 Activated CDC42 kinase 1 TNK2 0.0009
380 Cytochrome P450 17A1 CYP17A1 0.0009
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0009
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0009
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0009
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0009
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0009
297 Adenylate cyclase type 1 ADCY1 0.0009
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0008
465 Calmodulin CALM1 0.0008
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
2981 Phospholipase A2, membrane associated PLA2G2A 0.0008
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0008
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
740 Argininosuccinate synthase ASS1 0.0007
865 Argininosuccinate synthase ASS1 0.0007
2680 Argininosuccinate synthase argG 0.0007
3194 Argininosuccinate synthase argG 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
6021 Adenosine kinase ADK 0.0007
661 ADP/ATP translocase 1 SLC25A4 0.0007
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
4041 Microsomal glutathione S-transferase 2 MGST2 0.0006
291 Nitric-oxide synthase, endothelial NOS3 0.0006
871 Glucocorticoid receptor NR3C1 0.0006
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0006
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0006
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0006
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
207 Glutathione synthetase GSS 0.0006
5269 Glutathione synthetase gshB 0.0006
921 Glutamate receptor 2 GRIA2 0.0006
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0006
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0005
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0005
3932 Glutathione S-transferase A2 GSTA2 0.0005
4031 Glutathione S-transferase A1 GSTA1 0.0005
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0005
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
↑