DT-Web: DB00143

Identification
Name	Glutathione
Accession Number	DB00143 (EXPT01650, NUTR00029)
Type	small molecule
Description	A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. [PubChem]
Structure	MOL SDF PDB SMILES InChI
Categories ^(*)	Dietary supplement Micronutrient
Molecular Weight	307.323
Groups	approved
Monoisotopic Weight	307.083805981
Pharmacology
Indication	For nutritional supplementation, also for treating dietary shortage or imbalance
Mechanism of action	Glutathione (GSH) participates in leukotriene synthesis and is a cofactor for the enzyme glutathione peroxidase. It is also important as a hydrophilic molecule that is added to lipophilic toxins and waste in the liver during biotransformation before they can become part of the bile. Glutathione is also needed for the detoxification of methylglyoxal, a toxin produced as a by-product of metabolism. This detoxification reaction is carried out by the glyoxalase system. Glyoxalase I catalyzes the conversion of methylglyoxal and reduced glutathione to S-D-Lactoyl-glutathione. Glyoxalase II catalyzes the conversion of S-D-Lactoyl Glutathione to Reduced Glutathione and D-lactate. GSH is known as a cofactor in both conjugation reactions and reduction reactions, catalyzed by glutathione S-transferase enzymes in cytosol, microsomes, and mitochondria. However, it is capable of participating in non-enzymatic conjugation with some chemicals, as it is hypothesized to do to a significant extent with n-acetyl-p-benzoquinone imine (NAPQI), the reactive cytochrome P450 reactive metabolite formed by toxic overdose of acetaminophen. Glutathione in this capacity binds to NAPQI as a suicide substrate and in the process detoxifies it, taking the place of cellular protein sulfhydryl groups which would otherwise be toxically adducted. The preferred medical treatment to an overdose of this nature, whose efficacy has been consistently supported in literature, is the administration (usually in atomized form) of N-acetylcysteine, which is used by cells to replace spent GSSG and allow a usable GSH pool.
Absorption	Research suggests that glutathione is not orally bioactive, and that very little of oral glutathione tablets or capsules is actually absorbed by the body.
Protein binding	Not Available
Biotransformation	Not Available
Route of elimination	Not Available
Toxicity	ORL-MUS LD₅₀ 5000 mg/kg, IPR-MUS LD₅₀ 4020 mg/kg, SCU-MUS LD₅₀ 5000 mg/kg, IVN-RBT LD₅₀ > 2000 mg/kg, IMS-MUS LD₅₀ 4000 mg/kg
Affected organisms	Humans and other mammals
Interactions
Drug Interactions	Not Available
Food Interactions	Not Available

Microsomal glutathione S-transferase 3
Name	Microsomal glutathione S-transferase 3
Gene Name	MGST3
Pharmacological action	unknown
Actions	Not Available
References	Ago H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M: Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature. 2007 Aug 2;448(7153):609-12. Epub 2007 Jul 15. - Pubmed
DTHybrid score	1.042
Glutathione-requiring prostaglandin D synthase
Name	Glutathione-requiring prostaglandin D synthase
Gene Name	HPGDS
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Aritake K, Kado Y, Inoue T, Miyano M, Urade Y: Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17. - Pubmed Inoue T, Okano Y, Kado Y, Aritake K, Irikura D, Uodome N, Okazaki N, Kinugasa S, Shishitani H, Matsumura H, Kai Y, Urade Y: First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase. J Biochem (Tokyo). 2004 Mar;135(3):279-83. - Pubmed Urade Y, Kitahama K, Ohishi H, Kaneko T, Mizuno N, Hayaishi O: Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9070-4. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	2.0004
Thioredoxin domain-containing protein 12
Name	Thioredoxin domain-containing protein 12
Gene Name	TXNDC12
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.0421
Glutathione S-transferase A1
Name	Glutathione S-transferase A1
Gene Name	GSTA1
Pharmacological action	unknown
Actions	Not Available
References	Kim I, Keam B, Lee KH, Kim JH, Oh SY, Ra EK, Yoon SS, Park SS, Kim CS, Park S, Hong YC, Kim BK: Glutathione S-transferase A1 polymorphisms and acute graft-vs.-host disease in HLA-matched sibling allogeneic hematopoietic stem cell transplantation. Clin Transplant. 2007 Mar-Apr;21(2):207-13. - Pubmed Soderdahl T, Kuppers-Munther B, Heins N, Edsbagge J, Bjorquist P, Cotgreave I, Jernstrom B: Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells. Toxicol In Vitro. 2007 Aug;21(5):929-37. Epub 2007 Feb 2. - Pubmed Jonsson LS, Broberg K, Bergendorf U, Axmon A, Littorin M, Jonsson BA: Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. Int Arch Occup Environ Health. 2007 Jul;80(7):589-98. Epub 2007 Feb 28. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	1.5578
Glutathione S-transferase A2
Name	Glutathione S-transferase A2
Gene Name	GSTA2
Pharmacological action	unknown
Actions	Not Available
References	Sharma P, Ahmad Shah Z, Kumar A, Islam F, Mishra KP: Role of combined administration of Tiron and glutathione against aluminum-induced oxidative stress in rat brain. J Trace Elem Med Biol. 2007;21(1):63-70. Epub 2007 Feb 6. - Pubmed Skamarauskas J, Carter W, Fowler M, Madjd A, Lister T, Mavroudis G, Ray DE: The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation. Toxicology. 2007 Apr 11;232(3):268-76. Epub 2007 Jan 21. - Pubmed Ozkilic AC, Cengiz M, Ozaydin A, Cobanoglu A, Kanigur G: The role of N-acetylcysteine treatment on anti-oxidative status in patients with type II diabetes mellitus. J Basic Clin Physiol Pharmacol. 2006;17(4):245-54. - Pubmed Guruvayoorappan C, Afira AH, Kuttan G: Antioxidant potential of Biophytum sensitivum extract in vitro and in vivo. J Basic Clin Physiol Pharmacol. 2006;17(4):255-67. - Pubmed Gupta S, Sarotra P, Aggarwal R, Dutta N, Agnihotri N: Role of oxidative stress in celecoxib-induced renal damage in wistar rats. Dig Dis Sci. 2007 Nov;52(11):3092-8. Epub 2007 Mar 31. - Pubmed
DTHybrid score	0.8835
Microsomal glutathione S-transferase 1
Name	Microsomal glutathione S-transferase 1
Gene Name	MGST1
Pharmacological action	unknown
Actions	Not Available
References	Siritantikorn A, Johansson K, Ahlen K, Rinaldi R, Suthiphongchai T, Wilairat P, Morgenstern R: Protection of cells from oxidative stress by microsomal glutathione transferase 1. Biochem Biophys Res Commun. 2007 Apr 6;355(2):592-6. Epub 2007 Feb 12. - Pubmed Busenlehner LS, Alander J, Jegerscohld C, Holm PJ, Bhakat P, Hebert H, Morgenstern R, Armstrong RN: Location of substrate binding sites within the integral membrane protein microsomal glutathione transferase-1. Biochemistry. 2007 Mar 13;46(10):2812-22. Epub 2007 Feb 13. - Pubmed
DTHybrid score	1.0422
S-formylglutathione hydrolase
Name	S-formylglutathione hydrolase
Gene Name	ESD
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Yurimoto H, Lee B, Yano T, Sakai Y, Kato N: Physiological role of S-formylglutathione hydrolase in C(1) metabolism of the methylotrophic yeast Candida boidinii. Microbiology. 2003 Aug;149(Pt 8):1971-9. - Pubmed Neben I, Sahm H, Kula MR: Studies on an enzyme, S-formylglutathione hydrolase, of the dissimilatory pathway of methanol in Candida boidinii. Biochim Biophys Acta. 1980 Jul 10;614(1):81-91. - Pubmed Sabatier L, Hoffschir F, al Achkar WA, Turleau C, de Grouchy J, Dutrillaux B: The decrease of catalase or esterase D activity in patients with microdeletions of 11p or 13q does not increase their radiosensitivity. Ann Genet. 1989;32(3):144-8. - Pubmed
DTHybrid score	1.0413
Gamma-glutamyltranspeptidase 1
Name	Gamma-glutamyltranspeptidase 1
Gene Name	GGT1
Pharmacological action	unknown
Actions	Not Available
References	Ohkama-Ohtsu N, Zhao P, Xiang C, Oliver DJ: Glutathione conjugates in the vacuole are degraded by gamma-glutamyl transpeptidase GGT3 in Arabidopsis. Plant J. 2007 Mar;49(5):878-88. - Pubmed Martin MN, Saladores PH, Lambert E, Hudson AO, Leustek T: Localization of members of the gamma-glutamyl transpeptidase family identifies sites of glutathione and glutathione S-conjugate hydrolysis. Plant Physiol. 2007 Aug;144(4):1715-32. Epub 2007 Jun 1. - Pubmed Anilakumar KR, Nagaraj NS, Santhanam K: Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by Emblica officinalis gaertn. Indian J Exp Biol. 2007 May;45(5):450-4. - Pubmed Adamis PD, Panek AD, Eleutherio EC: Vacuolar compartmentation of the cadmium-glutathione complex protects Saccharomyces cerevisiae from mutagenesis. Toxicol Lett. 2007 Aug 30;173(1):1-7. Epub 2007 Jun 14. - Pubmed Zhu Y, Carvey PM, Ling Z: Altered glutathione homeostasis in animals prenatally exposed to lipopolysaccharide. Neurochem Int. 2007 Mar;50(4):671-80. Epub 2007 Jan 13. - Pubmed
DTHybrid score	1.0409
Glutathione S-transferase Mu 2
Name	Glutathione S-transferase Mu 2
Gene Name	GSTM2
Pharmacological action	unknown
Actions	Not Available
References	Kurtovic S, Jansson R, Mannervik B: Colorimetric endpoint assay for enzyme-catalyzed iodide ion release for high-throughput screening in microtiter plates. Arch Biochem Biophys. 2007 Aug 15;464(2):284-7. Epub 2007 Apr 24. - Pubmed Vararattanavech A, Ketterman AJ: A functionally conserved basic residue in glutathione transferases interacts with the glycine moiety of glutathione and is pivotal for enzyme catalysis. Biochem J. 2007 Sep 1;406(2):247-56. - Pubmed Gallagher EP, Huisden CM, Gardner JL: Transfection of HepG2 cells with hGSTA4 provides protection against 4-hydroxynonenal-mediated oxidative injury. Toxicol In Vitro. 2007 Apr 27;. - Pubmed Yalcinkaya S, Unlucerci Y, Uysal M: Methionine-supplemented diet augments hepatotoxicity and prooxidant status in chronically ethanol-treated rats. Exp Toxicol Pathol. 2007 Aug;58(6):455-9. Epub 2007 May 11. - Pubmed Roh JY, Jung IH, Lee JY, Choi J: Toxic effects of di(2-ethylhexyl)phthalate on mortality, growth, reproduction and stress-related gene expression in the soil nematode Caenorhabditis elegans. Toxicology. 2007 Jul 31;237(1-3):126-33. Epub 2007 May 18. - Pubmed
DTHybrid score	1.8398
Glutaredoxin-1
Name	Glutaredoxin-1
Gene Name	GLRX
Pharmacological action	unknown
Actions	Not Available
References	Diwakar L, Kenchappa RS, Annepu J, Ravindranath V: Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: implications in excitotoxicity. Neurochem Int. 2007 Jul;51(1):37-46. Epub 2007 Apr 5. - Pubmed Rouhier N, Unno H, Bandyopadhyay S, Masip L, Kim SK, Hirasawa M, Gualberto JM, Lattard V, Kusunoki M, Knaff DB, Georgiou G, Hase T, Johnson MK, Jacquot JP: Functional, structural, and spectroscopic characterization of a glutathione-ligated [2Fe-2S] cluster in poplar glutaredoxin C1. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7379-84. Epub 2007 Apr 25. - Pubmed Hakansson KO, Winther JR: Structure of glutaredoxin Grx1p C30S mutant from yeast. Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):288-94. Epub 2007 Feb 21. - Pubmed Lu J, Chew EH, Holmgren A: Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12288-93. Epub 2007 Jul 18. - Pubmed Wang J, Pan S, Berk BC: Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner. Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1283-8. Epub 2007 Apr 12. - Pubmed
DTHybrid score	1.0429
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
Name	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
Gene Name	GPX4
Pharmacological action	unknown
Actions	cofactor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Moreno SG, Laux G, Brielmeier M, Bornkamm GW, Conrad M: Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx). Biol Chem. 2003 Apr;384(4):635-43. - Pubmed Baek IJ, Seo DS, Yon JM, Lee SR, Jin Y, Nahm SS, Jeong JH, Choo YK, Kang JK, Lee BJ, Yun YW, Nam SY: Tissue expression and cellular localization of phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA in male mice. J Mol Histol. 2007 Jun;38(3):237-44. Epub 2007 May 15. - Pubmed Nam SY, Baek IJ, Lee BJ, In CH, Jung EY, Yon JM, Ahn B, Kang JK, Yu WJ, Yun YW: Effects of 17beta-estradiol and tamoxifen on the selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA expression in male reproductive organs of rats. J Reprod Dev. 2003 Oct;49(5):389-96. - Pubmed
DTHybrid score	1.05
Glutathione S-transferase Mu 5
Name	Glutathione S-transferase Mu 5
Gene Name	GSTM5
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Schnakenberg E, Breuer R, Werdin R, Dreikorn K, Schloot W: Susceptibility genes: GSTM1 and GSTM3 as genetic risk factors in bladder cancer. Cytogenet Cell Genet. 2000;91(1-4):234-8. - Pubmed Rao AV, Shaha C: Multiple glutathione S-transferase isoforms are present on male germ cell plasma membrane. FEBS Lett. 2001 Oct 26;507(2):174-80. - Pubmed
DTHybrid score	1.0461
Glutathione peroxidase 6
Name	Glutathione peroxidase 6
Gene Name	GPX6
Pharmacological action	unknown
Actions	cofactor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Brigelius-Flohe R: Glutathione peroxidases and redox-regulated transcription factors. Biol Chem. 2006 Oct-Nov;387(10-11):1329-35. - Pubmed Myllyla V, Kihlstrom M, Takala TE, Tolonen U, Salminen A, Vihko V: Activities of some antioxidative and hexose monophosphate shunt enzymes of skeletal muscle in neuromuscular diseases. Acta Neurol Scand. 1986 Jul;74(1):17-24. - Pubmed Giovannini C, Scazzocchio B, Matarrese P, Vari R, D'Archivio M, Di Benedetto R, Casciani S, Dessi MR, Straface E, Malorni W, Masella R: Apoptosis induced by oxidized lipids is associated with up-regulation of p66Shc in intestinal Caco-2 cells: protective effects of phenolic compounds. J Nutr Biochem. 2007 Jun 22;. - Pubmed
DTHybrid score	1.0483
Hydroxyacylglutathione hydrolase
Name	Hydroxyacylglutathione hydrolase
Gene Name	HAGH
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Ridderstrom M, Jemth P, Cameron AD, Mannervik B: The active-site residue tyr-175 in human glyoxalase II contributes to binding of glutathione derivatives. Biochim Biophys Acta. 2000 Sep 29;1481(2):344-8. - Pubmed Chyan MK, Elia AC, Principato GB, Giovannini E, Rosi G, Norton SJ: S-fluorenylmethoxycarbonyl glutathione and diesters: inhibition of mammalian glyoxalase II. Enzyme Protein. 1994-1995;48(3):164-73. - Pubmed Al-Timari A, Douglas KT: Inhibition by glutathione derivatives of bovine liver glyoxalase II (hydroxyacylglutathione hydrolase) as a probe of the N- and S-sites for substrate binding. Biochim Biophys Acta. 1986 Mar 28;870(2):219-25. - Pubmed
DTHybrid score	1.777
Hypothetical protein
Name	Hypothetical protein
Gene Name	GPX1
Pharmacological action	unknown
Actions	Not Available
References	Chattopadhyay S, Sahoo DK, Subudhi U, Chainy GB: Differential expression profiles of antioxidant enzymes and glutathione redox status in hyperthyroid rats: a temporal analysis. Comp Biochem Physiol C Toxicol Pharmacol. 2007 Sep;146(3):383-91. Epub 2007 May 3. - Pubmed Du X, Takagi H: N-Acetyltransferase Mpr1 confers ethanol tolerance on Saccharomyces cerevisiae by reducing reactive oxygen species. Appl Microbiol Biotechnol. 2007 Jul;75(6):1343-51. Epub 2007 Mar 27. - Pubmed Sheridan PA, Zhong N, Carlson BA, Perella CM, Hatfield DL, Beck MA: Decreased selenoprotein expression alters the immune response during influenza virus infection in mice. J Nutr. 2007 Jun;137(6):1466-71. - Pubmed Walshe J, Serewko-Auret MM, Teakle N, Cameron S, Minto K, Smith L, Burcham PC, Russell T, Strutton G, Griffin A, Chu FF, Esworthy S, Reeve V, Saunders NA: Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation. Cancer Res. 2007 May 15;67(10):4751-8. - Pubmed Sordillo LM, O'Boyle N, Gandy JC, Corl CM, Hamilton E: Shifts in thioredoxin reductase activity and oxidant status in mononuclear cells obtained from transition dairy cattle. J Dairy Sci. 2007 Mar;90(3):1186-92. - Pubmed
DTHybrid score	1.0516
Glutathione peroxidase 4
Name	Glutathione peroxidase 4
Gene Name	GPX4
Pharmacological action	unknown
Actions	cofactor
References	Baek IJ, Seo DS, Yon JM, Lee SR, Jin Y, Nahm SS, Jeong JH, Choo YK, Kang JK, Lee BJ, Yun YW, Nam SY: Tissue expression and cellular localization of phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA in male mice. J Mol Histol. 2007 Jun;38(3):237-44. Epub 2007 May 15. - Pubmed Cejas P, Garcia-Cabezas MA, Casado E, Belda-Iniesta C, De Castro J, Fresno JA, Sereno M, Barriuso J, Espinosa E, Zamora P, Feliu J, Redondo A, Hardisson DA, Renart J, Gonzalez-Baron M: Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma. Free Radic Res. 2007 Jun;41(6):681-7. - Pubmed Wang Z, Wang F, Duan R, Liu JY: Purification and physicochemical characterization of a recombinant phospholipid hydroperoxide glutathione peroxidase from Oryza sativa. J Biochem Mol Biol. 2007 May 31;40(3):412-8. - Pubmed Bertelsmann H, Sieme H, Behne D, Kyriakopoulos A: Is the distribution of selenium and zinc in the sublocations of spermatozoa regulated? Ann N Y Acad Sci. 2007 Jan;1095:204-8. - Pubmed Ding WQ, Lind SE: Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity. Mol Cancer Ther. 2007 Apr;6(4):1467-74. - Pubmed
DTHybrid score	1.05
CDNA FLJ23636 fis, clone CAS07176
Name	CDNA FLJ23636 fis, clone CAS07176
Gene Name	GPX8
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.0432
Glutathione peroxidase 7
Name	Glutathione peroxidase 7
Gene Name	GPX7
Pharmacological action	unknown
Actions	cofactor
References	Giovannini C, Scazzocchio B, Matarrese P, Vari R, D'Archivio M, Di Benedetto R, Casciani S, Dessi MR, Straface E, Malorni W, Masella R: Apoptosis induced by oxidized lipids is associated with up-regulation of p66Shc in intestinal Caco-2 cells: protective effects of phenolic compounds. J Nutr Biochem. 2007 Jun 22;. - Pubmed
DTHybrid score	1.0439
Microsomal glutathione S-transferase 2
Name	Microsomal glutathione S-transferase 2
Gene Name	MGST2
Pharmacological action	unknown
Actions	Not Available
References	Ago H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M: Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature. 2007 Aug 2;448(7153):609-12. Epub 2007 Jul 15. - Pubmed
DTHybrid score	0.9895
Glutathione transferase omega-2
Name	Glutathione transferase omega-2
Gene Name	GSTO2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Whitbread AK, Masoumi A, Tetlow N, Schmuck E, Coggan M, Board PG: Characterization of the omega class of glutathione transferases. Methods Enzymol. 2005;401:78-99. - Pubmed Board PG, Anders MW: Glutathione transferase omega 1 catalyzes the reduction of S-(phenacyl)glutathiones to acetophenones. Chem Res Toxicol. 2007 Jan;20(1):149-54. - Pubmed Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG: Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. Pharmacogenetics. 2003 Mar;13(3):131-44. - Pubmed
DTHybrid score	1.0424
Glutaredoxin-2, mitochondrial
Name	Glutaredoxin-2, mitochondrial
Gene Name	GLRX2
Pharmacological action	unknown
Actions	Not Available
References	Hashemy SI, Johansson C, Berndt C, Lillig CH, Holmgren A: Oxidation and S-nitrosylation of cysteines in human cytosolic and mitochondrial glutaredoxins: effects on structure and activity. J Biol Chem. 2007 May 11;282(19):14428-36. Epub 2007 Mar 13. - Pubmed Sagemark J, Elgan TH, Burglin TR, Johansson C, Holmgren A, Berndt KD: Redox properties and evolution of human glutaredoxins. Proteins. 2007 Sep 1;68(4):879-92. - Pubmed Sheng J, Ye J, Rosen BP: Crystallization and preliminary X-ray crystallographic analysis of Escherichia coliglutaredoxin 2 in complex with glutathione and of a cysteine-less variant without glutathione. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt 4):280-2. Epub 2007 Mar 12. - Pubmed
DTHybrid score	1.0424
Lactoylglutathione lyase
Name	Lactoylglutathione lyase
Gene Name	GLO1
Pharmacological action	unknown
Actions	Not Available
References	Barati MT, Merchant ML, Kain AB, Jevans AW, McLeish KR, Klein JB: Proteomic Analysis Defines Altered Cellular Redox Pathways and Advanced Glycation End Product (AGE) Metabolism in Glomeruli of db/db Diabetic Mice. Am J Physiol Renal Physiol. 2007 Jul 3;. - Pubmed Deponte M, Sturm N, Mittler S, Harner M, Mack H, Becker K: Allosteric Coupling of Two Different Functional Active Sites in Monomeric Plasmodium falciparum Glyoxalase I. J Biol Chem. 2007 Sep 28;282(39):28419-30. Epub 2007 Jul 30. - Pubmed
DTHybrid score	1.608
Leukotriene C4 synthase
Name	Leukotriene C4 synthase
Gene Name	LTC4S
Pharmacological action	unknown
Actions	Not Available
References	Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggstrom JZ, Nordlund P: Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase. Nature. 2007 Aug 2;448(7153):613-6. Epub 2007 Jul 15. - Pubmed Ago H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M: Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature. 2007 Aug 2;448(7153):609-12. Epub 2007 Jul 15. - Pubmed
DTHybrid score	1.0425
Glutathione reductase, mitochondrial
Name	Glutathione reductase, mitochondrial
Gene Name	GSR
Pharmacological action	unknown
Actions	Not Available
References	Messarah M, Boulakoud MS, Boumendjel A, Abdennour C, El Feki A: The impact of thyroid activity variations on some oxidizing-stress parameters in rats. C R Biol. 2007 Feb;330(2):107-12. Epub 2006 Dec 12. - Pubmed Brocardo PS, Assini F, Franco JL, Pandolfo P, Muller YM, Takahashi RN, Dafre AL, Rodrigues AL: Zinc attenuates malathion-induced depressant-like behavior and confers neuroprotection in the rat brain. Toxicol Sci. 2007 May;97(1):140-8. Epub 2007 Feb 27. - Pubmed Guruvayoorappan C, Afira AH, Kuttan G: Antioxidant potential of Biophytum sensitivum extract in vitro and in vivo. J Basic Clin Physiol Pharmacol. 2006;17(4):255-67. - Pubmed Markaryan AA, Dubinskaya VA, Dargaeva TD: Peroxide-eliminating oxidoreductases as biosensors of antioxidant components of medicinal plants. Bull Exp Biol Med. 2006 Jul;142(1):55-6. - Pubmed Maity S, Roy S, Chaudhury S, Bhattacharya S: Antioxidant responses of the earthworm Lampito mauritii exposed to Pb and Zn contaminated soil. Environ Pollut. 2007 May 16;. - Pubmed
DTHybrid score	1.5379
Glutathione synthetase
Name	Glutathione synthetase
Gene Name	GSS
Pharmacological action	unknown
Actions	Not Available
References	Herrera K, Cahoon RE, Kumaran S, Jez J: Reaction mechanism of glutathione synthetase from Arabidopsis thaliana: site-directed mutagenesis of active site residues. J Biol Chem. 2007 Jun 8;282(23):17157-65. Epub 2007 Apr 22. - Pubmed Mohanpuria P, Rana NK, Yadav SK: Cadmium induced oxidative stress influence on glutathione metabolic genes of Camellia sinensis (L.) O. Kuntze. Environ Toxicol. 2007 Aug;22(4):368-74. - Pubmed Forcella M, Berra E, Giacchini R, Parenti P: Antioxidant defenses preserve membrane transport activity in Chironomus riparius larvae exposed to anoxia. Arch Insect Biochem Physiol. 2007 Aug;65(4):181-94. - Pubmed Janaky R, Dohovics R, Saransaari P, Oja SS: Modulation of [3H]dopamine release by glutathione in mouse striatal slices. Neurochem Res. 2007 Aug;32(8):1357-64. Epub 2007 Mar 31. - Pubmed Bridges CC, Battle JR, Zalups RK: Transport of thiol-conjugates of inorganic mercury in human retinal pigment epithelial cells. Toxicol Appl Pharmacol. 2007 Jun 1;221(2):251-60. Epub 2007 Mar 23. - Pubmed
DTHybrid score	0.924
Glutathione S-transferase Mu 1
Name	Glutathione S-transferase Mu 1
Gene Name	GSTM1
Pharmacological action	unknown
Actions	Not Available
References	Moore LE, Malats N, Rothman N, Real FX, Kogevinas M, Karami S, Garcia-Closas R, Silverman D, Chanock S, Welch R, Tardon A, Serra C, Carrato A, Dosemeci M, Garcia-Closas M: Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer. Int J Cancer. 2007 Jun 1;120(11):2452-8. - Pubmed Sakoda LC, Blackston CR, Xue K, Doherty JA, Ray RM, Lin MG, Stalsberg H, Gao DL, Feng Z, Thomas DB, Chen C: Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women. Breast Cancer Res Treat. 2007 Jul 12;. - Pubmed Ouerhani S, Tebourski F, Slama MR, Marrakchi R, Rabeh M, Hassine LB, Ayed M, Elgaaied AB: The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population. Ann Hum Biol. 2006 Sep-Dec;33(5-6):529-35. - Pubmed Contreras-Vergara CA, Valenzuela-Soto E, Garcia-Orozco KD, Sotelo-Mundo RR, Yepiz-Plascencia G: A Mu-class glutathione S-transferase from gills of the marine shrimp Litopenaeus vannamei: purification and characterization. J Biochem Mol Toxicol. 2007;21(2):62-7. - Pubmed Schwartzbaum JA, Ahlbom A, Lonn S, Warholm M, Rannug A, Auvinen A, Christensen HC, Henriksson R, Johansen C, Lindholm C, Malmer B, Salminen T, Schoemaker MJ, Swerdlow AJ, Feychting M: An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):559-65. - Pubmed
DTHybrid score	1.4366
Glutathione S-transferase kappa 1
Name	Glutathione S-transferase kappa 1
Gene Name	GSTK1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Robinson A, Huttley GA, Booth HS, Board PG: Modelling and bioinformatics studies of the human Kappa-class glutathione transferase predict a novel third glutathione transferase family with similarity to prokaryotic 2-hydroxychromene-2-carboxylate isomerases. Biochem J. 2004 May 1;379(Pt 3):541-52. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	1.8768
Glutathione S-transferase A3
Name	Glutathione S-transferase A3
Gene Name	GSTA3
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Board PG: Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4. Biochem J. 1998 Mar 1;330 ( Pt 2):827-31. - Pubmed McHugh TE, Atkins WM, Racha JK, Kunze KL, Eaton DL: Binding of the aflatoxin-glutathione conjugate to mouse glutathione S-transferase A3-3 is saturated at only one ligand per dimer. J Biol Chem. 1996 Nov 1;271(44):27470-4. - Pubmed McDonagh PD, Judah DJ, Hayes JD, Lian LY, Neal GE, Wolf CR, Roberts GC: Determinants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferases. Biochem J. 1999 Apr 1;339 ( Pt 1):95-101. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	1.7836
Glutathione S-transferase Mu 3
Name	Glutathione S-transferase Mu 3
Gene Name	GSTM3
Pharmacological action	unknown
Actions	Not Available
References	Schwartzbaum JA, Ahlbom A, Lonn S, Warholm M, Rannug A, Auvinen A, Christensen HC, Henriksson R, Johansen C, Lindholm C, Malmer B, Salminen T, Schoemaker MJ, Swerdlow AJ, Feychting M: An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):559-65. - Pubmed Moore LE, Brennan P, Karami S, Hung RJ, Hsu C, Boffetta P, Toro J, Zaridze D, Janout V, Bencko V, Navratilova M, Szeszenia-Dabrowska N, Mates D, Mukeria A, Holcatova I, Welch R, Chanock S, Rothman N, Chow WH: Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. Carcinogenesis. 2007 Sep;28(9):1960-4. Epub 2007 Jul 7. - Pubmed
DTHybrid score	0.8426
Glutathione S-transferase A4
Name	Glutathione S-transferase A4
Gene Name	GSTA4
Pharmacological action	unknown
Actions	Not Available
References	Gallagher EP, Huisden CM, Gardner JL: Transfection of HepG2 cells with hGSTA4 provides protection against 4-hydroxynonenal-mediated oxidative injury. Toxicol In Vitro. 2007 Apr 27;. - Pubmed
DTHybrid score	1.0434
Glutathione S-transferase Mu 4
Name	Glutathione S-transferase Mu 4
Gene Name	GSTM4
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Cantlay AM, Smith CA, Wallace WA, Yap PL, Lamb D, Harrison DJ: Heterogeneous expression and polymorphic genotype of glutathione S-transferases in human lung. Thorax. 1994 Oct;49(10):1010-4. - Pubmed Beuckmann CT, Fujimori K, Urade Y, Hayaishi O: Identification of mu-class glutathione transferases M2-2 and M3-3 as cytosolic prostaglandin E synthases in the human brain. Neurochem Res. 2000 May;25(5):733-8. - Pubmed Efferth T, Volm M: Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate. In Vivo. 2005 Jan-Feb;19(1):225-32. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	1.7373
Glutathione S-transferase A5
Name	Glutathione S-transferase A5
Gene Name	GSTA5
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed McDonagh PD, Judah DJ, Hayes JD, Lian LY, Neal GE, Wolf CR, Roberts GC: Determinants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferases. Biochem J. 1999 Apr 1;339 ( Pt 1):95-101. - Pubmed McLeod R, Ellis EM, Arthur JR, Neal GE, Judah DJ, Manson MM, Hayes JD: Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin. Cancer Res. 1997 Oct 1;57(19):4257-66. - Pubmed Kazi S, Ellis EM: Expression of rat liver glutathione-S-transferase GSTA5 in cell lines provides increased resistance to alkylating agents and toxic aldehydes. Chem Biol Interact. 2002 May 20;140(2):121-35. - Pubmed
DTHybrid score	1.0469
Glutathione S-transferase P
Name	Glutathione S-transferase P
Gene Name	GSTP1
Pharmacological action	unknown
Actions	Not Available
References	Ramachandran K, Navarro L, Gordian E, Das PM, Singal R: Methylation-mediated silencing of genes is not altered by selenium treatment of prostate cancer cells. Anticancer Res. 2007 Mar-Apr;27(2):921-5. - Pubmed Kadokawa Y, Ohba K, Omagari K, Akazawa S, Hayashida K, Ohnita K, Takeshima F, Mizuta Y, Kohno S: Intracellular balance of oxidative stress and cytoprotective molecules in damaged interlobular bile ducts in autoimmune hepatitis and primary biliary cirrhosis: In situ detection of 8-hydroxydeoxyguanosine and glutathione-S-transferase-pi. Hepatol Res. 2007 Aug;37(8):620-7. Epub 2007 May 22. - Pubmed
DTHybrid score	1.3985
Glutathione transferase omega-1
Name	Glutathione transferase omega-1
Gene Name	GSTO1
Pharmacological action	unknown
Actions	Not Available
References	Tulayakul P, Dong KS, Li JY, Manabe N, Kumagai S: The effect of feeding piglets with the diet containing green tea extracts or coumarin on in vitro metabolism of aflatoxin B1 by their tissues. Toxicon. 2007 Sep 1;50(3):339-48. Epub 2007 Apr 22. - Pubmed Harju TH, Peltoniemi MJ, Rytila PH, Soini Y, Salmenkivi KM, Board PG, Ruddock LW, Kinnula VL: Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients. Respir Res. 2007 Jul 6;8:48. - Pubmed
DTHybrid score	0.8402
Glutathione peroxidase 1
Name	Glutathione peroxidase 1
Gene Name	GPX1
Pharmacological action	unknown
Actions	cofactor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Destro-Bisol G, Spedini G: Anthropological survey on red cell glutathione peroxidase (GPX1) polymorphism in central western Africa: a tentative hypothesis on the interaction between GPX12 and Hb beta S allelic products. Am J Phys Anthropol. 1989 Jun;79(2):217-24. - Pubmed Liddell JR, Hoepken HH, Crack PJ, Robinson SR, Dringen R: Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity. J Neurosci Res. 2006 Aug 15;84(3):578-86. - Pubmed Ursini F, Maiorino M: Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR) does not differ between normo- and hypomotile human sperm samples. Int J Androl. 2005 Feb;28(1):61-2; author reply 63-4. - Pubmed
DTHybrid score	1.051
Glutathione peroxidase 2
Name	Glutathione peroxidase 2
Gene Name	GPX2
Pharmacological action	unknown
Actions	cofactor
References	Walshe J, Serewko-Auret MM, Teakle N, Cameron S, Minto K, Smith L, Burcham PC, Russell T, Strutton G, Griffin A, Chu FF, Esworthy S, Reeve V, Saunders NA: Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation. Cancer Res. 2007 May 15;67(10):4751-8. - Pubmed
DTHybrid score	1.0467
Glutathione S-transferase theta-1
Name	Glutathione S-transferase theta-1
Gene Name	GSTT1
Pharmacological action	unknown
Actions	Not Available
References	Ouerhani S, Tebourski F, Slama MR, Marrakchi R, Rabeh M, Hassine LB, Ayed M, Elgaaied AB: The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population. Ann Hum Biol. 2006 Sep-Dec;33(5-6):529-35. - Pubmed Schwartzbaum JA, Ahlbom A, Lonn S, Warholm M, Rannug A, Auvinen A, Christensen HC, Henriksson R, Johansen C, Lindholm C, Malmer B, Salminen T, Schoemaker MJ, Swerdlow AJ, Feychting M: An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):559-65. - Pubmed Moore LE, Brennan P, Karami S, Hung RJ, Hsu C, Boffetta P, Toro J, Zaridze D, Janout V, Bencko V, Navratilova M, Szeszenia-Dabrowska N, Mates D, Mukeria A, Holcatova I, Welch R, Chanock S, Rothman N, Chow WH: Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. Carcinogenesis. 2007 Sep;28(9):1960-4. Epub 2007 Jul 7. - Pubmed Gawecki W, Kostrzewska-Poczekaj M, Gajecka M, Milecki P, Szyfter K, Szyfter W: The role of genetic factor in etiopathogenesis of squamous cell carcinoma of the head and neck in young adults. Eur Arch Otorhinolaryngol. 2007 Jul 26;. - Pubmed Jonsson LS, Broberg K, Bergendorf U, Axmon A, Littorin M, Jonsson BA: Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. Int Arch Occup Environ Health. 2007 Jul;80(7):589-98. Epub 2007 Feb 28. - Pubmed
DTHybrid score	0.642
Maleylacetoacetate isomerase
Name	Maleylacetoacetate isomerase
Gene Name	GSTZ1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Fernandez-Canon JM, Baetscher MW, Finegold M, Burlingame T, Gibson KM, Grompe M: Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism. Mol Cell Biol. 2002 Jul;22(13):4943-51. - Pubmed Hagedorn SR, Chapman PJ: Glutathione-independent maleylacetoacetate isomerase in gram-positive bacteria. J Bacteriol. 1985 Aug;163(2):803-5. - Pubmed Lim CE, Matthaei KI, Blackburn AC, Davis RP, Dahlstrom JE, Koina ME, Anders MW, Board PG: Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases. Am J Pathol. 2004 Aug;165(2):679-93. - Pubmed
DTHybrid score	0.799
Epididymal secretory glutathione peroxidase
Name	Epididymal secretory glutathione peroxidase
Gene Name	GPX5
Pharmacological action	unknown
Actions	cofactor
References	Koh CS, Didierjean C, Navrot N, Panjikar S, Mulliert G, Rouhier N, Jacquot JP, Aubry A, Shawkataly O, Corbier C: Crystal structures of a poplar thioredoxin peroxidase that exhibits the structure of glutathione peroxidases: insights into redox-driven conformational changes. J Mol Biol. 2007 Jul 13;370(3):512-29. Epub 2007 Apr 19. - Pubmed
DTHybrid score	1.0484
Glutathione peroxidase 3
Name	Glutathione peroxidase 3
Gene Name	GPX3
Pharmacological action	unknown
Actions	cofactor
References	Jacobson GA, Yee KC, Ng CH: Elevated plasma glutathione peroxidase concentration in acute severe asthma: comparison with plasma glutathione peroxidase activity, selenium and malondialdehyde. Scand J Clin Lab Invest. 2007;67(4):423-30. - Pubmed Carmeli E, Bachar A, Barchad S: Biochemical assessments of total antioxidant status in active and nonactive female adults with intellectual disability. Res Sports Med. 2007 Apr-Jun;15(2):93-101. - Pubmed
DTHybrid score	1.0487

Glutathione S-transferase A2
Name	Glutathione S-transferase A2
Gene Name	GSTA2
Actions	substrate
References	- Hayes JD, Flanagan JU, Jowsey IR: Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005;45:51-88. - Pubmed Armstrong RN: Glutathione S-transferases: reaction mechanism, structure, and function. Chem Res Toxicol. 1991 Mar-Apr;4(2):131-40. - Pubmed
DTHybrid score	0.8835
Glutathione S-transferase A1
Name	Glutathione S-transferase A1
Gene Name	GSTA1
Actions	substrate
References	- Hayes JD, Flanagan JU, Jowsey IR: Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005;45:51-88. - Pubmed Armstrong RN: Glutathione S-transferases: reaction mechanism, structure, and function. Chem Res Toxicol. 1991 Mar-Apr;4(2):131-40. - Pubmed
DTHybrid score	1.5578

Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	substrate,inhibitor
References	Heijn M, Hooijberg JH, Scheffer GL, Szabo G, Westerhoff HV, Lankelma J: Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. Biochim Biophys Acta. 1997 May 22;1326(1):12-22. - Pubmed Evers R, de Haas M, Sparidans R, Beijnen J, Wielinga PR, Lankelma J, Borst P: Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83. - Pubmed Jedlitschky G, Leier I, Buchholz U, Barnouin K, Kurz G, Keppler D: Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res. 1996 Mar 1;56(5):988-94. - Pubmed Minich T, Riemer J, Schulz JB, Wielinga P, Wijnholds J, Dringen R: The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes. J Neurochem. 2006 Apr;97(2):373-84. Epub 2006 Mar 15. - Pubmed
DTHybrid score	0.5354
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate,inhibitor
References	Paulusma CC, van Geer MA, Evers R, Heijn M, Ottenhoff R, Borst P, Oude Elferink RP: Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione. Biochem J. 1999 Mar 1;338 ( Pt 2):393-401. - Pubmed Hagmann W, Nies AT, Konig J, Frey M, Zentgraf H, Keppler D: Purification of the human apical conjugate export pump MRP2 reconstitution and functional characterization as substrate-stimulated ATPase. Eur J Biochem. 1999 Oct 1;265(1):281-9. - Pubmed Nishida T, Gatmaitan Z, Roy-Chowdhry J, Arias IM: Two distinct mechanisms for bilirubin glucuronide transport by rat bile canalicular membrane vesicles. Demonstration of defective ATP-dependent transport in rats (TR-) with inherited conjugated hyperbilirubinemia. J Clin Invest. 1992 Nov;90(5):2130-5. - Pubmed Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ: Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology. 2000 Feb;118(2):422-30. - Pubmed Madon J, Hagenbuch B, Landmann L, Meier PJ, Stieger B: Transport function and hepatocellular localization of mrp6 in rat liver. Mol Pharmacol. 2000 Mar;57(3):634-41. - Pubmed
DTHybrid score	0.6014
Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	substrate
References	Zelcer N, Saeki T, Reid G, Beijnen JH, Borst P: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7. - Pubmed
DTHybrid score	0.5527
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	substrate
References	Lai L, Tan TM: Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem J. 2002 Feb 1;361(Pt 3):497-503. - Pubmed
DTHybrid score	0.5881
Multidrug resistance-associated protein 5
Name	Multidrug resistance-associated protein 5
Gene Name	ABCC5
Actions	substrate
References	Minich T, Riemer J, Schulz JB, Wielinga P, Wijnholds J, Dringen R: The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes. J Neurochem. 2006 Apr;97(2):373-84. Epub 2006 Mar 15. - Pubmed
DTHybrid score	0.5647

Id	Partner name	Gene Name	Score
4297	Hypothetical protein	SP_1951	1.0516
4521	Hypothetical protein	BC_2969	1.0516
4540	Hypothetical protein	TM_1070	1.0516
4555	Hypothetical protein	MT1739	1.0516
4569	Hypothetical protein	mshD	1.0516
4578	Hypothetical protein	PA3270	1.0516
4747	Hypothetical protein	PA3967	1.0516
5177	Hypothetical protein	TM_0096	1.0516
5194	Hypothetical protein	PA1204	1.0516
5240	Hypothetical protein	Rv2991	1.0516
5370	Hypothetical protein	TM_1158	1.0516
5710	Hypothetical protein	Tb927.5.1360	1.0516
5269	Glutathione synthetase	gshB	0.924
3759	Glutathione S-transferase	gst	0.1997
4541	Glutathione S-transferase	GST	0.1997
4512	Cytochrome P450 3A4	CYP3A4	0.1925
1588	Multidrug resistance protein 1	ABCB1	0.175
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1588
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.1515
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.1449
3947	Xanthine dehydrogenase/oxidase	XDH	0.1138
5360	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	PDE9A	0.1126
4757	Cytochrome P450 2C9	CYP2C9	0.1073
1729	Solute carrier family 22 member 6	SLC22A6	0.1041
4077	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	0.1007
86	SEC14-like protein 4	SEC14L4	0.1006
375	SEC14-like protein 3	SEC14L3	0.1006
4076	Diacylglycerol kinase alpha	DGKA	0.1006
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.1005
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0983
4924	Cytochrome P450 2C8	CYP2C8	0.0982
4200	Cytochrome P450 1A2	CYP1A2	0.0976
6163	Copper-transporting ATPase 2	ATP7B	0.0928
6165	Copper-transporting ATPase 1	ATP7A	0.0928
6137	Multidrug resistance-associated protein 6	ABCC6	0.0899
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0881
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0877
6146	High affinity copper uptake protein 1	SLC31A1	0.0867
1405	Thiopurine S-methyltransferase	TPMT	0.083
2300	Lysozyme	E	0.0819
3633	Lysozyme	R	0.0819
5597	Lysozyme	17	0.0819
4118	Cytochrome P450 3A5	CYP3A5	0.0818
2314	Triosephosphate isomerase	TPI	0.0816
3417	Triosephosphate isomerase	tpiA	0.0816
3443	Triosephosphate isomerase	tpiA	0.0816
6346	Triosephosphate isomerase	TPI1	0.0816
6142	Solute carrier family 22 member 8	SLC22A8	0.0814
283	SEC14-like protein 2	SEC14L2	0.0801
708	Alpha-tocopherol transfer protein	TTPA	0.0787
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0787
587	Serum albumin	ALB	0.0757
6013	Cytochrome P450 2E1	CYP2E1	0.0753
4078	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	0.0716
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0711
997	Protein kinase C beta type	PRKCB	0.0706
6030	Cytochrome P450 2B6	CYP2B6	0.0684
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0669
776	Bile salt export pump	ABCB11	0.0654
1970	Protein kinase C alpha type	PRKCA	0.0651
6148	Multidrug resistance-associated protein 7	ABCC10	0.065
1757	Myeloperoxidase	MPO	0.0632
6143	Solute carrier family 22 member 7	SLC22A7	0.0625
6144	Solute carrier family 22 member 2	SLC22A2	0.0624
6016	Cytochrome P450 2C19	CYP2C19	0.0606
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0594
275	Arachidonate 5-lipoxygenase	ALOX5	0.0594
6024	Cytochrome P450 1A1	CYP1A1	0.0572
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.057
810	Heme oxygenase 1	HMOX1	0.0564
3391	Heme oxygenase 1	pbsA1	0.0564
6107	Cytochrome P450 3A7	CYP3A7	0.0554
4119	Cytochrome P450 2D6	CYP2D6	0.0553
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0538
290	Prostaglandin G/H synthase 2	PTGS2	0.0533
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0511
468	Cytochrome P450 4A11	CYP4A11	0.0502
817	DNA topoisomerase 2-alpha	TOP2A	0.0486
6147	Solute carrier family 22 member 3	SLC22A3	0.046
6141	Sodium/bile acid cotransporter	SLC10A1	0.0459
5898	Complement C3	C3	0.0453
6145	Solute carrier family 22 member 1	SLC22A1	0.044
1024	Solute carrier family 22 member 11	SLC22A11	0.0434
3191	Histidinol dehydrogenase	hisD	0.0424
2409	Acetyl-CoA acetyltransferase, cytosolic	ACAT2	0.0418
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0405
5718	Cytochrome P450 2A6	CYP2A6	0.0404
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0402
2443	Azurin	azu	0.0399
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0387
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0387
1898	Cytochrome P450 1B1	CYP1B1	0.0381
20	Prostaglandin G/H synthase 1	PTGS1	0.0373
6677	Myelin P2 protein	PMP2	0.0365
5226	Protein ninB	ninB	0.0364
5626	Nucleoside diphosphate kinase B	NME2	0.0364
24	Thymidylate synthase	TMP1	0.0363
359	Thymidylate synthase	TYMS	0.0363
2626	Thymidylate synthase	thyA	0.0363
2729	Thymidylate synthase	thyA	0.0363
5352	Thymidylate synthase	THYA	0.0363
5669	50S ribosomal protein L27	rpmA	0.0362
5670	Organic hydroperoxide resistance protein	ohr	0.0361
5672	Molybdenum cofactor biosynthesis protein A	moaA	0.0361
5675	Chaperone protein torD	torD	0.0361
5410	Unsaturated glucuronyl hydrolase	ugl	0.0361
5676	Axin-1	AXIN1	0.0361
5673	C protein alpha-antigen	bca	0.0361
2517	Subtilisin BPN'	apr	0.0347
3766	Pyridoxamine 5'-phosphate oxidase	pdxH	0.0318
2596	Acetyl-CoA acetyltransferase	phbA	0.0317
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0317
1277	Alpha-1-antitrypsin	SERPINA1	0.0317
3317	Holo-[acyl-carrier-protein] synthase	acpS	0.0316
4381	Holo-[acyl-carrier-protein] synthase	acpS	0.0316
3125	Protease synthase and sporulation negative regulatory protein PAI 1	paiA	0.0316
2636	Shikimate dehydrogenase	aroE	0.0312
3515	Shikimate dehydrogenase	aroE	0.0312
6579	Calcium/calmodulin-dependent protein kinase type II alpha chain	CAMK2A	0.0311
5294	Nucleoside diphosphate kinase A	NME1	0.0308
558	Solute carrier family 12 member 1	SLC12A1	0.0298
2826	Glucose--fructose oxidoreductase	gfo	0.0294
4192	DNA topoisomerase 2-beta	TOP2B	0.0293
118	Organic cation/carnitine transporter 2	SLC22A5	0.0291
2280	Listeriolysin regulatory protein	prfA	0.029
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0288
191	Peptide methionine sulfoxide reductase	MSRA	0.0288
4811	Amylosucrase	ams	0.0286
4084	Peptidyl-prolyl cis-trans isomerase B	PPIB	0.0282
4549	Endonuclease III	HP_0602	0.0277
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0271
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0269
203	Pyridoxine-5'-phosphate oxidase	PNPO	0.0255
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.025
611	Retinal dehydrogenase 1	ALDH1A1	0.0249
2112	Toll-like receptor 9	TLR9	0.0237
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0233
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0231
738	Monocarboxylate transporter 1	SLC16A1	0.023
342	P protein [Includes: DNA-directed DNA polymerase	P	0.023
612	P protein [Includes: DNA-directed DNA polymerase	P	0.023
6085	Fatty acid-binding protein, intestinal	FABP2	0.0229
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0222
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0221
777	Tumor necrosis factor	TNF	0.022
171	Cysteine dioxygenase	CDO-1	0.022
1314	Thiamine transporter 2	SLC19A3	0.0219
4064	Probable cysteinyl-tRNA synthetase, mitochondrial	CARS2	0.0219
774	Cysteinyl-tRNA synthetase, cytoplasmic	CARS	0.0219
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0216
4604	Liver carboxylesterase 1	CES1	0.0215
2852	DNA mismatch repair protein mutL	mutL	0.0201
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0197
3685	Catabolite gene activator	crp	0.0191
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0191
4655	Adenylate cyclase	cyaC	0.0191
4759	Adenylate cyclase	cyaB2	0.0191
626	Cysteine dioxygenase type 1	CDO1	0.0186
1999	Methylated-DNA--protein-cysteine methyltransferase	MGMT	0.0186
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0186
3923	Cholinesterase	BCHE	0.0184
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0184
6167	Organic solute transporter subunit beta	OSTB	0.0183
6166	Organic solute transporter subunit alpha	OSTA	0.0183
731	HIV-1 protease	HIV-1 protease	0.0177
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0176
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0176
89	Cysteine sulfinic acid decarboxylase	CSAD	0.0174
477	DNA topoisomerase 4 subunit A	parC	0.017
886	DNA topoisomerase 4 subunit A	parC	0.017
6226	DNA topoisomerase 4 subunit A	parC	0.017
6149	Solute carrier family 22 member 10	SLC22A10	0.017
1650	Heme carrier protein 1	SLC46A1	0.0168
6020	Aldehyde oxidase	AOX1	0.0168
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0168
404	DNA gyrase subunit A	gyrA	0.0168
6224	DNA gyrase subunit A	gyrA	0.0168
169	Cysteine desulfurase, mitochondrial	NFS1	0.0165
293	Gamma-glutamyl hydrolase	GGH	0.0165
4760	Mll3241 protein	mll3241	0.0163
13	Aminomethyltransferase, mitochondrial	AMT	0.0163
3116	Bacterioferritin	bfr	0.016
4906	Bacterioferritin	bfr	0.016
4965	Bacterioferritin	bfr	0.016
3709	Glycerol uptake facilitator protein	glpF	0.016
3173	Enolase	eno	0.016
3238	Multidrug resistance protein mexA	mexA	0.016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.016
3393	TGF-beta receptor type-2	TGFBR2	0.016
70	Type-1 angiotensin II receptor	AGTR1	0.0158
358	Cystathionine beta-synthase	CBS	0.0157
868	Cystathionine gamma-lyase	CTH	0.0156
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0153
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0153
6042	Prostaglandin reductase 2	PTGR2	0.0153
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0152
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0152
6151	Monocarboxylate transporter 10	SLC16A10	0.015
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.015
4602	Osmotically inducible protein C	tthHB8IM	0.0149
2664	S-ribosylhomocysteine lyase	luxS	0.0149
2725	S-ribosylhomocysteine lyase	luxS	0.0149
2670	Pyridoxamine kinase	pdxY	0.0149
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0149
161	Tubulin beta chain	TUBB	0.0148
312	Tubulin beta chain	TUB2	0.0148
4226	Uridine phosphorylase 2	UPP2	0.0146
3957	Adenosine deaminase	ADA	0.0145
136	Estrogen receptor	ESR1	0.0145
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0143
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0143
461	Glycine receptor subunit alpha-3	GLRA3	0.0142
6171	Solute carrier family 28 member 3	SLC28A3	0.014
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0136
6043	Putative G-protein coupled receptor 44	GPR44	0.0136
3599	Peroxiredoxin-2	PRDX2	0.013
4601	HMG-CoA synthase	mvaS	0.013
4225	Uridine phosphorylase 1	UPP1	0.013
3307	Acriflavine resistance protein B	acrB	0.013
2688	Peptide deformylase	def	0.013
2708	Peptide deformylase	def	0.013
3004	Peptide deformylase	def	0.013
4337	Peptide deformylase	def	0.013
4338	Peptide deformylase	def	0.013
5368	Peptide deformylase	def	0.013
5371	Peptide deformylase	def	0.013
6375	Peptide deformylase	def	0.013
6378	Peptide deformylase	def	0.013
6379	Peptide deformylase	def	0.013
6776	Peptide deformylase	def	0.013
6900	Peptide deformylase	def	0.013
2378	Carboxymethylenebutenolidase	clcD	0.013
2705	Dimethyl sulfoxide reductase	dmsA	0.0129
6459	Glycodelin	PAEP	0.0129
6218	Pannexin-1	PANX1	0.0126
3221	Cytochrome c4	cc4	0.0124
413	Amidophosphoribosyltransferase	PPAT	0.0124
2515	Amidophosphoribosyltransferase	purF	0.0124
3714	Amidophosphoribosyltransferase	purF	0.0124
33	Cystine/glutamate transporter	SLC7A11	0.0123
3587	Gastrotropin	FABP6	0.0122
702	UMP-CMP kinase	CMPK1	0.012
2714	Chorismate mutase	aroH	0.012
4611	Chorismate mutase	aroG	0.012
2603	Beta-lactamase II	blm	0.0119
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0118
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
299	Folate receptor beta	FOLR2	0.0117
718	Folate receptor gamma	FOLR3	0.0117
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0116
4311	tRNA	TRDMT1	0.0116
4325	tRNA	trmD	0.0116
4328	tRNA	trmD	0.0116
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0116
6106	Cytochrome P450 2C18	CYP2C18	0.0115
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0115
4692	A/G-specific adenine glycosylase	mutY	0.0115
4600	Malonamidase E2	Not Available	0.0113
2802	Endoglucanase G	celCCG	0.0112
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0112
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.011
6316	ADP-ribosylation factor 1	ARF1	0.0109
444	Alcohol dehydrogenase 1B	ADH1B	0.0108
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0107
833	Organic cation/carnitine transporter 1	SLC22A4	0.0107
489	Monocarboxylate transporter 2	SLC16A7	0.0107
614	Progesterone receptor	PGR	0.0106
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0105
4217	Telomerase reverse transcriptase	TERT	0.0104
3639	Thymidine phosphorylase	deoA	0.0101
3936	Thymidine phosphorylase	TYMP	0.0101
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0101
4773	Deoxycytidine kinase	DCK	0.01
5646	Galactokinase	GALK1	0.0099
5265	FtsH	ftsH	0.0099
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0099
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0099
5302	TrwB	trwB	0.0099
3811	Cytochrome P450 19A1	CYP19A1	0.0098
273	Apoptosis regulator Bcl-2	BCL2	0.0098
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0097
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0094
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0093
4058	Glycine N-acyltransferase-like protein 2	GLYATL2	0.0093
4057	Glycine N-acyltransferase	GLYAT	0.0093
4061	Peroxisomal sarcosine oxidase	PIPOX	0.0093
4055	Bile acid CoA:amino acid N-acyltransferase	BAAT	0.0093
4056	N-arachidonyl glycine receptor	GPR18	0.0093
4060	Vesicular inhibitory amino acid transporter	SLC32A1	0.0093
4059	Glycine N-acyltransferase-like protein 1	GLYATL1	0.0093
1088	5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	0.0093
1236	Sodium- and chloride-dependent glycine transporter 1	SLC6A9	0.0093
1466	Glycyl-tRNA synthetase	GARS	0.0093
4062	Sodium- and chloride-dependent glycine transporter 2	SLC6A5	0.0093
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0093
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
952	Dipeptidyl peptidase 4	DPP4	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
29	Tubulin beta-1 chain	TUBB1	0.009
2539	Tubulin alpha-1 chain	TUBA4A	0.0089
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0089
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0088
5312	Kinesin-like protein KIF1A	KIF1A	0.0088
6220	Aryl hydrocarbon receptor	AHR	0.0086
504	Mast/stem cell growth factor receptor	KIT	0.0085
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0084
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0084
1760	Aminopeptidase N	ANPEP	0.0083
6843	Aminopeptidase N	pepN	0.0083
2892	Acetylglutamate kinase	argB	0.0083
3550	Acetylglutamate kinase	argB	0.0083
2371	Pantothenate kinase	coaA	0.0082
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0082
284	DNA-directed RNA polymerase beta chain	rpoB	0.0082
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0082
3884	SHMT2 protein	SHMT2	0.0081
3901	SHMT2 protein	SHMT2	0.0081
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0081
3879	Serine hydroxymethyltransferase 2	Not Available	0.0081
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0081
850	Vasopressin V1b receptor	AVPR1B	0.0081
117	Sterol O-acyltransferase 1	SOAT1	0.0081
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0081
2615	Chemotaxis protein cheA	cheA	0.0081
1881	Hexokinase-1	HK1	0.0081
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0081
26	Vascular endothelial growth factor receptor 3	FLT4	0.008
1141	Sialidase-1	NEU1	0.008
64	Neuraminidase	NA	0.008
641	Neuraminidase	NA	0.008
2676	Neuraminidase	NA	0.008
3026	Neuraminidase	NA	0.008
3519	Neuraminidase	NA	0.008
6007	Neuraminidase	NA	0.008
165	FL cytokine receptor	FLT3	0.008
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0079
2320	Thymidine kinase, cytosolic	TK1	0.0078
4120	NADPH--cytochrome P450 reductase	POR	0.0077
32	Vascular endothelial growth factor receptor 1	FLT1	0.0077
2727	S-adenosylmethionine synthetase	metK	0.0077
4054	Glycine cleavage system H protein, mitochondrial	GCSH	0.0077
5923	Microtubule-associated protein tau	MAPT	0.0076
5924	Microtubule-associated protein 4	MAP4	0.0076
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0075
575	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	0.0074
455	5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	0.0074
681	Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	0.0074
62	Glycine receptor subunit beta	GLRB	0.0074
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0074
5818	Folate receptor alpha	FOLR1	0.0073
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0073
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0072
6031	Cytochrome P450 3A43	CYP3A43	0.0072
1648	Elastin	ELN	0.0072
185	Vasopressin V1a receptor	AVPR1A	0.0071
2417	Chloramphenicol acetyltransferase	cat	0.0071
3278	Chloramphenicol acetyltransferase	cat	0.0071
1852	Microtubule-associated protein 2	MAP2	0.0071
411	Glycine N-methyltransferase	GNMT	0.007
5641	Rod shape-determining protein MreB	TM_0588	0.007
4178	DNA repair protein RAD51 homolog 1	RAD51	0.007
5649	Potassium-transporting ATPase B chain	kdpB	0.007
3794	Osmolarity sensor protein envZ	envZ	0.007
5644	Sensor protein phoQ	phoQ	0.007
5643	General secretion pathway protein E	epsE	0.007
5645	DNA topoisomerase 4 subunit B	parE	0.007
6227	DNA topoisomerase 4 subunit B	parE	0.007
5642	Chaperone clpB	clpB	0.007
322	Vasopressin V2 receptor	AVPR2	0.007
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0069
383	Glycine amidinotransferase, mitochondrial	GATM	0.0069
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0068
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0068
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0068
2298	Cytochrome P450-cam	camC	0.0068
380	Cytochrome P450 17A1	CYP17A1	0.0067
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0067
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0067
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0066
2391	Ferrochelatase	hemH	0.0066
6502	Ferrochelatase	DKFZp686P18130	0.0066
1591	Ferrochelatase, mitochondrial	FECH	0.0066
1629	Transcription factor AP-1	JUN	0.0066
2251	Thymidylate kinase	tmk	0.0066
2254	Thymidylate kinase	DTYMK	0.0066
3522	Thymidylate kinase	tmk	0.0066
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0065
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0065
4751	Mitogen-activated protein kinase 12	MAPK12	0.0064
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0063
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0063
824	Sodium-dependent serotonin transporter	SLC6A4	0.0063
593	Proton-coupled amino acid transporter 1	SLC36A1	0.0063
349	Serine--pyruvate aminotransferase	AGXT	0.0063
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0063
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0063
5482	Sialidase-2	NEU2	0.0062
3270	Elongation factor G	fusA	0.0062
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0062
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0061
407	Vascular endothelial growth factor receptor 2	KDR	0.0061
2397	Dihydroxyacetone kinase	dhaK	0.0061
2867	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	ispE	0.0061
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0061
820	Glycine receptor subunit alpha-2	GLRA2	0.0061
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0061
6432	Transporter	snf	0.0061
6433	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	PFKFB4	0.0061
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0061
3822	Actin, alpha skeletal muscle	ACTA1	0.0061
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0061
2808	Chloramphenicol acetyltransferase 3	cat3	0.0061
723	Cytosolic phospholipase A2	PLA2G4A	0.006
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0059
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0059
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0058
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0058
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0058
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0058
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0057
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0057
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0057
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0057
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0057
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0057
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0057
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0057
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0057
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0057
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0057
6559	Cytochrome c oxidase subunit 2	ctaC	0.0057
6669	Cytochrome c oxidase subunit 2	ctaC	0.0057
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0057
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0057
6558	Cytochrome c oxidase subunit 1	ctaD	0.0057
2299	UDP-N-acetylmuramate--L-alanine ligase	murC	0.0057
3231	Death-associated protein kinase 1	DAPK1	0.0056
6210	Tubulin delta chain	TUBD1	0.0056
6212	Tubulin gamma-1 chain	TUBG1	0.0056
6211	Tubulin epsilon chain	TUBE1	0.0056
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0056
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0055
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0054
887	DNA gyrase subunit B	gyrB	0.0054
4150	DNA gyrase subunit B	gyrB	0.0054
6225	DNA gyrase subunit B	gyrB	0.0054
936	Ephrin type-A receptor 2	EPHA2	0.0053
958	Insulin-like growth factor 1 receptor	IGF1R	0.0053
2540	Choloylglycine hydrolase	cbh	0.0052
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0052
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0052
482	Glycine receptor subunit alpha-1	GLRA1	0.0052
517	Alcohol dehydrogenase 1C	ADH1C	0.0051
3810	Catechol O-methyltransferase	COMT	0.005
6168	Solute carrier family 22 member 16	SLC22A16	0.0049
6501	Fatty acid-binding protein, liver	FABP1	0.0049
6033	High affinity interleukin-8 receptor A	CXCR1	0.0049
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0049
597	Dihydropteridine reductase	QDPR	0.0048
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0048
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0048
1198	Serum paraoxonase/arylesterase 1	PON1	0.0047
6223	Penicillin-binding protein 1C	pbpC	0.0047
4498	Ornithine cyclodeaminase	PP3533	0.0047
2021	Thrombomodulin	THBD	0.0046
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0046
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0046
76	Nitric-oxide synthase, brain	NOS1	0.0045
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0045
6837	Serine/threonine-protein kinase 17B	STK17B	0.0045
3809	Estrogen-related receptor gamma	ESRRG	0.0045
365	Dihydrofolate reductase	DHFR	0.0044
2381	Dihydrofolate reductase	DFR1	0.0044
2833	Dihydrofolate reductase	Not Available	0.0044
2931	Dihydrofolate reductase	folA	0.0044
3544	Dihydrofolate reductase	folA	0.0044
3682	Dihydrofolate reductase	folA	0.0044
6642	Dihydrofolate reductase	folA	0.0044
6756	Dihydrofolate reductase	dfrA	0.0044
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0044
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0044
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0044
737	Mineralocorticoid receptor	NR3C2	0.0042
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0042
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0042
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0042
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0042
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0042
6500	Phospholipase A2	PLA2G1B	0.0041
1050	Bile salt sulfotransferase	SULT2A1	0.0041
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0041
2683	Mono-ADP-ribosyltransferase C3	C3	0.0041
2449	Tubulin alpha-3 chain	TUBA1A	0.0041
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.004
5251	Carbonyl reductase [NADPH] 1	CBR1	0.004
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.004
1836	Mitogen-activated protein kinase 10	MAPK10	0.004
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.004
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.004
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.004
340	Apoptotic protease-activating factor 1	APAF1	0.004
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0039
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0039
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0039
373	Transthyretin	TTR	0.0039
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0038
5293	Shikimate kinase 2	aroL	0.0038
5288	Shikimate kinase	aroK	0.0038
5304	UPF0166 protein TM_0021	TM_0021	0.0038
5287	Signaling protein	Not Available	0.0038
5292	Putative partitioning protein	TT_C1605	0.0038
5266	Activator of	hgdC	0.0038
5259	Transcriptional regulator	ntrC1	0.0038
6699	Transcriptional regulator	Cgl2612	0.0038
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0038
3199	Phosphopantetheine adenylyltransferase	coaD	0.0038
3543	Phosphopantetheine adenylyltransferase	coaD	0.0038
3567	Phosphopantetheine adenylyltransferase	coaD	0.0038
5289	Phosphopantetheine adenylyltransferase	coaD	0.0038
2874	Nitrogenase iron protein 1	nifH1	0.0038
4346	Polynucleotide kinase	pseT	0.0038
5283	D-alanine--D-alanine ligase B	ddlB	0.0038
5281	Plasmid segregation protein parM	parM	0.0038
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0038
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0038
5315	Chaperone protein htpG	htpG	0.0038
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0038
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0038
5291	Glycogen synthase 1	glgA1	0.0038
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0038
5264	DNA replication protein	REP	0.0038
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0038
5308	Preprotein translocase secA 1 subunit	secA1	0.0038
5285	Kinesin heavy chain	KIF5B	0.0038
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0038
5299	D-alanine--D-alanine ligase	ddl	0.0038
6598	D-alanine--D-alanine ligase	ddl	0.0038
5284	Large T antigen	Not Available	0.0038
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0038
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0038
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0038
5277	Preprotein translocase subunit secA	secA	0.0038
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0038
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0038
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0038
2232	Interleukin-5	IL5	0.0037
260	Cytochrome P450 51	ERG11	0.0037
761	Cytochrome P450 51	ERG11	0.0037
3163	Cytochrome P450 51	cyp51	0.0037
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0037
4238	50S ribosomal protein L4	rplD	0.0037
5578	50S ribosomal protein L4	rplD	0.0037
6173	50S ribosomal protein L4	rplD	0.0037
6219	50S ribosomal protein L4	rplD	0.0037
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0037
1593	Mucin-2	MUC2	0.0037
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0037
2236	Casein kinase II subunit alpha	CSNK2A1	0.0037
6138	Multidrug resistance protein 3	ABCB4	0.0037
5787	Angiopoietin-1 receptor	TEK	0.0037
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0037
7	Nitric oxide synthase, inducible	NOS2	0.0036
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0036
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0036
5448	Ribonuclease Z	rnz	0.0035
5449	Hypothetical gliding protein	mglB	0.0035
3781	Thiol:disulfide interchange protein dsbC precursor	dsbC	0.0035
4705	Manganese catalase	Not Available	0.0035
5439	33 kDa chaperonin	hslO	0.0035
332	Beta-lactamase	blaZ	0.0035
2478	Beta-lactamase	ampC	0.0035
2613	Beta-lactamase	ampC	0.0035
2635	Beta-lactamase	ampC	0.0035
2700	Beta-lactamase	penP	0.0035
5445	Beta-lactamase	blaB	0.0035
6019	Beta-lactamase	SHV-7	0.0035
6701	Beta-lactamase	cphA	0.0035
5443	UPF0189 protein ymdB	ymdB	0.0035
5446	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	HI_1679	0.0035
5440	UPF0067 protein yebR	yebR	0.0035
2720	Copper-containing nitrite reductase	nirK	0.0035
5454	Internalin-A	inlA	0.0035
5447	Lethal(3)malignant brain tumor-like protein	L3MBTL1	0.0035
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0035
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0035
5117	Dihydrolipoyl dehydrogenase	lpd	0.0035
4486	Phenol 2-hydroxylase component B	pheA2	0.0035
4439	Ferredoxin reductase	bphA4	0.0035
183	Vascular endothelial growth factor A	VEGFA	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
2599	Tyrosine-protein kinase HCK	HCK	0.0034
992	Protein tyrosine kinase 2 beta	PTK2B	0.0034
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0033
1353	DNA topoisomerase 1	TOP1	0.0033
3552	DNA topoisomerase 1	topA	0.0033
871	Glucocorticoid receptor	NR3C1	0.0032
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0032
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0032
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0032
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0032
844	Epidermal growth factor receptor	EGFR	0.0032
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0032
1792	Tissue-type plasminogen activator	PLAT	0.0032
4440	NADH peroxidase	npr	0.0032
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0031
1123	Eosinophil cationic protein	RNASE3	0.0031
3426	Glutamine synthetase	glnA	0.0031
3987	Glutamine synthetase	GLUL	0.0031
3175	Glutamate--cysteine ligase	gshA	0.0031
5450	Prolyl endopeptidase Pep	pep	0.0031
4771	Dissimilatory copper-containing nitrite reductase	nir	0.0031
3356	Diaminopimelate decarboxylase	lysA	0.0031
3274	Hydroxylamine reductase	hcp	0.0031
4804	Hydroxylamine reductase	hcp	0.0031
131	Synaptic vesicular amine transporter	SLC18A2	0.0031
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0031
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0031
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0031
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0031
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.003
3470	Hypothetical protein MG245 homolog	MPN_348	0.003
115	Penicillin-binding protein 2	mrdA	0.003
6069	Penicillin-binding protein 2	mrdA	0.003
6118	Penicillin-binding protein 2	penA	0.003
6187	Penicillin-binding protein 2	pbpA	0.003
6686	Penicillin-binding protein 2	pbp2	0.003
6939	Penicillin-binding protein 2	mrdA	0.003
7163	Penicillin-binding protein 2	pbpA	0.003
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.003
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.003
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.003
5189	Trimethylamine dehydrogenase	tmd	0.003
4106	Guanylate kinase	GUK1	0.003
4516	Guanylate kinase	gmk	0.003
2270	Dephospho-CoA kinase	coaE	0.003
2284	Adenylate kinase	adk	0.003
2296	Adenylate kinase	adk	0.003
2311	Adenylate kinase	adk	0.003
2312	Adenylate kinase	Not Available	0.003
6277	Heat shock cognate 71 kDa protein	HSPA8	0.003
4837	Cag-alfa	cag-alfa	0.003
4839	DNA polymerase III subunit tau	dnaX	0.003
4774	NTPase P4	Not Available	0.003
4838	PMS1 protein homolog 2	PMS2	0.003
327	Glutathione reductase	gor	0.0029
5110	Glutathione reductase	GR2	0.0029
869	Estrogen receptor beta	ESR2	0.0029
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0029
291	Nitric-oxide synthase, endothelial	NOS3	0.0029
3399	Limonene-1,2-epoxide hydrolase	limA	0.0029
3462	Tyrosine-protein kinase transforming protein Abl	ABL	0.0028
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0028
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.0028
543	Penicillin-binding protein 1B	mrcB	0.0028
6186	Penicillin-binding protein 1B	ponB	0.0028
6822	Penicillin-binding protein 1b	pbp1b	0.0028
6844	Penicillin-binding protein 1b	pbp1b	0.0028
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0028
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0028
1	Peptidoglycan synthetase ftsI	ftsI	0.0028
4155	Peptidoglycan synthetase ftsI	ftsI	0.0028
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0028
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0028
5300	Antigen peptide transporter 1	TAP1	0.0028
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0028
645	Penicillin-binding protein 1A	mrcA	0.0028
5805	Penicillin-binding protein 1A	ponA	0.0028
6185	Penicillin-binding protein 1A	mrcA	0.0028
6799	Penicillin-binding protein 1A	pbpA	0.0028
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0028
465	Calmodulin	CALM1	0.0028
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0028
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0027
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0027
5180	L(+)-mandelate dehydrogenase	mdlB	0.0027
3500	Putative family 31 glucosidase yicI	yicI	0.0027
4608	Putative cytochrome P450	SCO1207	0.0027
4963	Putative cytochrome P450	SCO2884	0.0027
6254	Putative cytochrome P450	SCO6998	0.0027
1569	G1/S-specific cyclin-D1	CCND1	0.0027
5271	Focal adhesion kinase 1	PTK2	0.0027
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0027
2390	Nonsecretory ribonuclease	RNASE2	0.0027
2922	Glycerol kinase	glpK	0.0027
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0027
577	Argininosuccinate lyase	ASL	0.0026
1615	Chymase	CMA1	0.0026
2282	Protein recA	recA	0.0026
2315	Protein recA	recA	0.0026
2332	Protein recA	recA	0.0026
5263	Protein recA	recA	0.0026
408	Riboflavin kinase	RFK	0.0026
921	Glutamate receptor 2	GRIA2	0.0026
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0025
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0025
788	Creatine kinase M-type	CKM	0.0025
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0025
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0025
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0025
3669	Ribokinase	rbsK	0.0025
5122	Mersacidin decarboxylase	mrsD	0.0024
526	Thioredoxin reductase	trxB	0.0024
3767	Thioredoxin reductase	trxB	0.0024
3133	UDP-galactopyranose mutase	glf	0.0024
5099	UDP-galactopyranose mutase	glf	0.0024
5095	Putidaredoxin reductase	camA	0.0024
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0024
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0024
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0024
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0024
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0024
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0024
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0024
5109	Outer membrane protein p64k or PM-6	m-6	0.0024
5115	FkbI	fkbI	0.0024
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0024
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0024
5083	Cryptochrome DASH	cry	0.0024
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0024
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0024
5081	L-aspartate oxidase	nadB	0.0024
5111	Phenylacetone monooxygenase	pamO	0.0024
1410	Oxidoreductase	HSD17B6	0.0024
4725	Oxidoreductase	Not Available	0.0024
5124	Oxidoreductase	Not Available	0.0024
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0024
6228	Nuclear receptor coactivator 1	NCOA1	0.0024
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0024
146	Androgen receptor	AR	0.0024
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0024
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0024
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0024
287	Beta-1,4-galactosyltransferase 1	B4GALT1	0.0024
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0024
6241	Nuclear receptor coactivator 2	NCOA2	0.0024
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0024
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.0023
2334	Dethiobiotin synthetase	bioD	0.0023
6555	Dethiobiotin synthetase	bioD	0.0023
2697	Uridine-cytidine kinase 2	UCK2	0.0022
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0022
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0022
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0022
816	Biliverdin reductase A	BLVRA	0.0022
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0022
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0022
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0021
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0021
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0021
5073	Ferredoxin--NADP reductase	petH	0.0021
5076	Ferredoxin--NADP reductase	fpr	0.0021
5119	Ferredoxin--NADP reductase	petH	0.0021
5121	Ferredoxin--NADP reductase	fpr	0.0021
2526	NADPH-ferredoxin reductase fprA	fprA	0.0021
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0021
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0021
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0021
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.0021
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0021
5072	N,N-dimethylglycine oxidase	dmg	0.0021
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.0021
2470	Pyruvate oxidase	pox5	0.0021
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.0021
3594	Deoxyribodipyrimidine photo-lyase	phr	0.0021
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.0021
5080	Deoxyribodipyrimidine photo-lyase	phr	0.0021
48	Pyridoxal kinase	PDXK	0.0021
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0021
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0021
2268	Cholesterol oxidase	choB	0.0021
2822	Cholesterol oxidase	choA	0.0021
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0021
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0021
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0021
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0021
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0021
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0021
328	Sorbitol dehydrogenase	SORD	0.0021
396	Alcohol dehydrogenase 4	ADH4	0.0021
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0021
2091	Endoplasmin	HSP90B1	0.002
3102	Flavohemoprotein	hmp	0.002
4969	Flavohemoprotein	hmp	0.002
6395	Myosin-14	MYH14	0.002
12	Alcohol dehydrogenase class 3	ADH5	0.002
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.002
1630	Integrin beta-2	ITGB2	0.002
77	L-lactate dehydrogenase B chain	LDHB	0.002
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.002
2893	Glycine oxidase	thiO	0.002
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0019
1422	Serine/threonine-protein kinase 6	AURKA	0.0019
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0019
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0019
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0019
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0019
3379	Kinesin-like protein KIF11	KIF11	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0019
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0019
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.0019
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0018
2823	Trypanothione reductase	TPR	0.0018
2567	Thymidylate synthase thyX	thyX	0.0018
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0018
126	D-lactate dehydrogenase	dld	0.0018
3545	D-lactate dehydrogenase	Not Available	0.0018
4510	D-lactate dehydrogenase	ldhA	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
605	Fumarate reductase flavoprotein subunit	frdA	0.0018
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0018
3673	Fumarate reductase flavoprotein subunit	fccA	0.0018
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0018
6549	Fumarate reductase flavoprotein subunit	frdA	0.0018
2769	P-hydroxybenzoate hydroxylase	pobA	0.0018
2809	P-hydroxybenzoate hydroxylase	pobA	0.0018
509	Thymidine kinase	TK	0.0018
570	Thymidine kinase	TK	0.0018
2559	Thymidine kinase	TK	0.0018
3430	Thymidine kinase	tdk	0.0018
3518	Thymidine kinase	TK	0.0018
5301	Thymidine kinase	tdk	0.0018
5771	Thymidine kinase	ORF36	0.0018
7009	Thymidine kinase	ORF36	0.0018
1176	Mitogen-activated protein kinase 1	MAPK1	0.0018
2380	Monomeric sarcosine oxidase	soxA	0.0017
569	Retinal dehydrogenase 2	ALDH1A2	0.0017
251	Alcohol dehydrogenase 1A	ADH1A	0.0016
6044	Serum paraoxonase/lactonase 3	PON3	0.0016
6645	D-amino-acid oxidase	DAO	0.0016
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0016
5682	Ribonuclease pancreatic	RNASE1	0.0016
4495	3-oxoacyl-(Acyl carrier protein) reductase	TM_1169	0.0015
4423	Levodione reductase	lvr	0.0015
4456	Inorganic polyphosphate/ATP-NAD kinase	ppnK	0.0015
4428	Redox-sensing transcriptional repressor rex	rex	0.0015
4449	ADP-ribosyltransferase	Not Available	0.0015
4471	CDP-D-glucose-4,6-dehydratase	ascB	0.0015
4455	Glycerol dehydrogenase	gldA	0.0015
4435	L-aspartate dehydrogenase	nadX	0.0015
4466	Glutathione-independent formaldehyde dehydrogenase	fdhA	0.0015
4446	3alpha-hydroxysteroid dehydrogenase/carbonyl reductase	Not Available	0.0015
4472	Glucose 1-dehydrogenase	Not Available	0.0015
4487	Transcriptional regulator nadR	nadR	0.0015
4505	Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	bphB	0.0015
4443	Quinate/shikimate dehydrogenase	ydiB	0.0015
4500	L-lactate dehydrogenase 2	ldh2	0.0015
4447	Hypothetical protein yhfP	yhfP	0.0015
4336	Glyceraldehyde 3-phosphate dehydrogenase	Not Available	0.0015
4436	Glyceraldehyde 3-phosphate dehydrogenase	tthHB8IM	0.0015
3381	Alcohol dehydrogenase	Not Available	0.0015
4508	Alcohol dehydrogenase	adhA	0.0015
4414	Dehydrogenase	TT_P0035	0.0015
2350	3-isopropylmalate dehydrogenase	leuB	0.0015
3092	3-isopropylmalate dehydrogenase	leuB	0.0015
4418	AGR_L_3209p	AGR_L_3209	0.0015
4507	Alanine dehydrogenase	ald	0.0015
4475	Hypothetical protein Rv0046c/MT0052	ino1	0.0015
4497	Benzyl alcohol dehydrogenase	xylB	0.0015
4506	Myo-inositol-1-phosphate synthase-related protein	TM_1419	0.0015
3735	NAD(P) transhydrogenase subunit alpha part 1	pntAA	0.0015
4502	Formate dehydrogenase	Not Available	0.0015
3729	Citrate synthase	gltA	0.0015
4575	Citrate synthase	cit	0.0015
4580	Citrate synthase	gltA	0.0015
4451	Vip2Ac	vip2Ac	0.0015
4467	Alpha-glucosidase, putative	TM_0752	0.0015
4448	L-2-hydroxyisocaproate dehydrogenase	Not Available	0.0015
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0015
572	Integrin alpha-L	ITGAL	0.0015
474	Acetylcholinesterase	ACHE	0.0015
357	Carbonic anhydrase 2	CA2	0.0014
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0014
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0014
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0014
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
4122	Histone deacetylase 2	HDAC2	0.0014
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.0013
3598	dTDP-4-dehydrorhamnose reductase	rfbD	0.0013
4427	TDP-glucose-4,6-dehydratase	desIV	0.0013
3177	dTDP-glucose 4,6-dehydratase	rfbB	0.0013
4499	dTDP-glucose 4,6-dehydratase	rmlB	0.0013
4503	NADPH-flavin oxidoreductase	frp	0.0013
4482	UDP-galactose 4-epimerase	galE	0.0013
2967	CDP-paratose 2-epimerase	rfbE	0.0013
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0013
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
1199	GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1	ART1	0.0013
2424	L-lactate dehydrogenase	ldh	0.0013
2641	L-lactate dehydrogenase	Not Available	0.0013
4437	L-lactate dehydrogenase	ldh	0.0013
4442	L-lactate dehydrogenase	ldh	0.0013
3401	D-2-hydroxyisocaproate dehydrogenase	Not Available	0.0013
2538	6-phospho-beta-glucosidase bglT	bglT	0.0013
2336	2,3-diketo-L-gulonate reductase	dlgD	0.0013
2507	Diphtheria toxin	Not Available	0.0013
3081	3-dehydroquinate synthase	aroB	0.0013
3615	Dihydrodipicolinate reductase	dapB	0.0013
3618	Dihydrodipicolinate reductase	dapB	0.0013
4462	Dihydrodipicolinate reductase	dapB	0.0013
2393	Maltose-6'-phosphate glucosidase	glvA	0.0013
4509	Acetoin(diacetyl) reductase	budC	0.0013
6698	Dehydrogenase/reductase SDR family member 4-like 2	DHRS4L2	0.0013
2591	Urocanate hydratase	hutU	0.0013
2831	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	Not Available	0.0013
3059	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	fabG3	0.0013
2018	Deoxyhypusine synthase	DHPS	0.0013
4496	C-terminal-binding protein 1	CTBP1	0.0013
4450	Iota toxin component Ia	Not Available	0.0013
2881	Gamma-aminobutyraldehyde dehydrogenase	prr	0.0013
751	Potassium channel subfamily K member 6	KCNK6	0.0012
3296	Nicotinamide mononucleotide adenylyltransferase 1	NMNAT1	0.0011
4504	WbpP	Not Available	0.0011
4318	Siroheme synthase	cysG	0.0011
3367	GDP-mannose 6-dehydrogenase	algD	0.0011
4343	Alpha-glucosidase	aglA	0.0011
2799	Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	Not Available	0.0011
172	Potassium channel subfamily K member 1	KCNK1	0.0011
63	Malate dehydrogenase	mdh	0.0011
2329	Malate dehydrogenase	mdh	0.0011
3445	Malate dehydrogenase	mdh	0.0011
4420	Malate dehydrogenase	mdh	0.0011
4438	Malate dehydrogenase	mdh	0.0011
84	Nuclear receptor 0B1	NR0B1	0.0011
2617	Nitric oxide synthase oxygenase	nos	0.0011
2701	Nitric oxide synthase oxygenase	nos	0.0011
4476	Mannitol dehydrogenase	mtlD	0.0011
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0011
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0011
3333	Nicotinamide mononucleotide adenylyltransferase 3	NMNAT3	0.0011
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.0011
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.0011
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.0011
3070	Adenosylhomocysteinase	AHCY	0.0011
4424	Adenosylhomocysteinase	PFE1050w	0.0011
6278	Adenosylhomocysteinase	ahcY	0.0011
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.0011
1192	Sulfotransferase 1A1	SULT1A1	0.0011
469	Annexin A1	ANXA1	0.001
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.001
3939	Amine oxidase [flavin-containing] B	MAOB	0.001
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.001
666	NADP-dependent malic enzyme	ME1	0.001
857	Malate dehydrogenase, mitochondrial	MDH2	0.001
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.001
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.001
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.001
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.001
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.001
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.001
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.001
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.001
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.001
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.001
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.001
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.001
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.001
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.001
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.001
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.001
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.001
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.001
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.001
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.001
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.001
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.001
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.001
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.001
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.001
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.001
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.001
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.001
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.001
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.001
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.001
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.001
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.001
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.001
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.001
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.001
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.001
107	C-4 methylsterol oxidase	SC4MOL	0.001
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.001
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.001
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.001
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.001
729	GDP-L-fucose synthetase	TSTA3	0.001
3463	GDP-L-fucose synthetase	fcl	0.001
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.001
167	L-lactate dehydrogenase C chain	LDHC	0.001
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.001
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.001
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.001
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.001
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.001
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.001
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.001
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.001
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.001
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.001
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.001
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.001
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.001
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.001
644	Heme oxygenase 2	HMOX2	0.001
4982	Heme oxygenase 2	pbsA2	0.001
206	3-keto-steroid reductase	HSD17B7	0.001
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.001
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.001
34	7-dehydrocholesterol reductase	DHCR7	0.001
711	UDP-glucose 6-dehydrogenase	UGDH	0.001
3672	UDP-glucose 6-dehydrogenase	hasB	0.001
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.001
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.001
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.001
3726	D-3-phosphoglycerate dehydrogenase	serA	0.001
4291	D-3-phosphoglycerate dehydrogenase	serA	0.001
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.001
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.001
643	Peroxisomal bifunctional enzyme	EHHADH	0.001
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.001
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.001
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.001
825	Arsenical pump-driving ATPase	ASNA1	0.001
3435	Arsenical pump-driving ATPase	arsA	0.001
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.001
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.001
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.001
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.001
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.001
733	Activin receptor type 1B	ACVR1B	0.001
154	AFG3-like protein 2	AFG3L2	0.001
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.001
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.001
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.001
395	ALK tyrosine kinase receptor	Not Available	0.001
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.001
2286	Isocitrate dehydrogenase [NADP]	icd	0.001
2302	Isocitrate dehydrogenase [NADP]	icd	0.001
2771	Isocitrate dehydrogenase [NADP]	icd	0.001
4491	DNA ligase, NAD-dependent	ligA	0.001
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.001
3941	Amine oxidase [flavin-containing] A	MAOA	0.0009
2762	UDP-glucose 4-epimerase	GALE	0.0009
3461	UDP-glucose 4-epimerase	galE	0.0009
292	Activin receptor type-1	ACVR1	0.0009
849	Activated CDC42 kinase 1	TNK2	0.0009
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0009
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0009
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0009
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0009
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0009
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0009
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0009
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0009
297	Adenylate cyclase type 1	ADCY1	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0008
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0008
6026	Alcohol dehydrogenase 6	ADH6	0.0008
627	11-cis retinol dehydrogenase	RDH5	0.0008
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0008
654	Flavin reductase	BLVRB	0.0008
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0008
484	Tyrosine-protein kinase ABL2	ABL2	0.0008
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0008
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0008
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0008
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0008
279	Tyrosinase	TYR	0.0007
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0007
740	Argininosuccinate synthase	ASS1	0.0007
865	Argininosuccinate synthase	ASS1	0.0007
2680	Argininosuccinate synthase	argG	0.0007
3194	Argininosuccinate synthase	argG	0.0007
6021	Adenosine kinase	ADK	0.0007
661	ADP/ATP translocase 1	SLC25A4	0.0007
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0007
822	Aldose reductase	AKR1B1	0.0007
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0006
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0006

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00143 - Glutathione

Targets

Enzymes

Transporters

Predictions