DT-Web

DB01165 - Ofloxacin


Identification
Name Ofloxacin
Accession Number DB01165 (APRD00502)
Type small molecule
Description A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 361.3675
Groups approved
Monoisotopic Weight 361.143784348
Pharmacology
Indication For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.
Mechanism of action Ofloxacin acts on DNA gyrase and toposiomerase IV, enzymes which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription. By inhibiting their function, the drug thereby inhibits normal cell division.
Absorption Bioavailability of ofloxacin in the tablet formulation is approximately 98%
Protein binding 32%
Biotransformation Hepatic
Route of elimination Elimination is mainly by renal excretion. Between 65% and 80% of an administered oral dose of ofloxacin is excreted unchanged via the kidneys within 48 hours of dosing. Four to eight percent of an ofloxacin dose is excreted in the feces. This indicates a small degree of biliary excretion of ofloxacin.
Toxicity LD50=5450 mg/kg (orally in mice)
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The quinolone antibiotic, ofloxacin, may increase the anticoagulant effect of acenocoumarol.
Aluminium Formation of non-absorbable complexes
Anisindione The quinolone antibiotic, ofloxacin, may increase the anticoagulant effect of anisindione.
Calcium Formation of non-absorbable complexes
Calcium Acetate Calcium salts such as calcium acetate may decrease the absorption of quinolone antibiotics such as ofloxacin. Of concern only with oral administration of both agents. Interactions can be minimized by administering oral quinolone at least 2 hours before, or 6 hours after, the dose of an oral calcium supplement. Monitor for decreased therapeutic effects of oral quinolones if administered with oral calcium supplements.
Dicumarol The quinolone antibiotic, ofloxacin, may increase the anticoagulant effect of dicumarol.
Dihydroquinidine barbiturate Increased risk of cardiotoxicity and arrhythmias
Foscarnet Increased risk of convulsions
Iron Formation of non-absorbable complexes
Iron Dextran Formation of non-absorbable complexes
Magnesium Formation of non-absorbable complexes
Magnesium oxide Formation of non-absorbable complexes
Procainamide Ofloxacin may increase the effect of procainamide.
Quinidine Increased risk of cardiotoxicity and arrhythmias
Quinidine barbiturate Increased risk of cardiotoxicity and arrhythmias
Sucralfate Formation of non-absorbable complexes
Tacrine The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by strong CYP1A2 inhibitors such as Ofloxacin. Consider modifying therapy to avoid Tacrine toxicity. Monitor the efficacy and toxicity of Tacrine if Ofloxacin is initiated, discontinued or if the dose is changed.
Thiothixene The strong CYP1A2 inhibitor, Ofloxacin, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Ofloxacin is initiated, discontinued or dose changed.
Tizanidine Ofloxacin may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Warfarin The quinolone antibiotic, ofloxacin, may increase the anticoagulant effect of warfarin.
Zinc Formation of non-absorbable complexes
Food Interactions
  • Take without regard to meals.
  • Avoid high doses of caffeine.

Targets


DNA topoisomerase 4 subunit A
Name DNA topoisomerase 4 subunit A
Gene Name parC
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Turner AK, Nair S, Wain J: The acquisition of full fluoroquinolone resistance in Salmonella Typhi by accumulation of point mutations in the topoisomerase targets. J Antimicrob Chemother. 2006 Oct;58(4):733-40. Epub 2006 Aug 8. - Pubmed
  • Chau TT, Campbell JI, Galindo CM, Van Minh Hoang N, Diep TS, Nga TT, Van Vinh Chau N, Tuan PQ, Page AL, Ochiai RL, Schultsz C, Wain J, Bhutta ZA, Parry CM, Bhattacharya SK, Dutta S, Agtini M, Dong B, Honghui Y, Anh DD, Canh DG, Naheed A, Albert MJ, Phetsouvanh R, Newton PN, Basnyat B, Arjyal A, La TT, Rang NN, Phuong LT, Van Be Bay P, von Seidlein L, Dougan G, Clemens JD, Vinh H, Hien TT, Chinh NT, Acosta CJ, Farrar J, Dolecek C: Salmonella enterica Serovar Typhi: Antimicrobial drug resistance in Asia and the molecular mechanism of reduced susceptibility to the fluoroquinolones. Antimicrob Agents Chemother. 2007 Oct 1;. - Pubmed
  • Ishiguro F, Toho M, Yamazaki M, Matsuyuki S, Moriya K, Tanaka D, Isobe J, Kyota Y, Muraoka M: [Mutations of gyrA gene and parC gene in fluoroquinolone-resistant Escherichia coli isolates from sporadic diarrheal cases] Kansenshogaku Zasshi. 2006 Sep;80(5):507-12. - Pubmed
  • Drlica K, Zhao X: DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. - Pubmed
DTHybrid score 0.9507
DNA gyrase subunit A
Name DNA gyrase subunit A
Gene Name gyrA
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Schmitz FJ, Hofmann B, Hansen B, Scheuring S, Luckefahr M, Klootwijk M, Verhoef J, Fluit A, Heinz HP, Kohrer K, Jones ME: Relationship between ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and moxifloxacin (BAY 12-8039) MICs and mutations in grlA, grlB, gyrA and gyrB in 116 unrelated clinical isolates of Staphylococcus aureus. J Antimicrob Chemother. 1998 Apr;41(4):481-4. - Pubmed
  • Cambau E, Sougakoff W, Besson M, Truffot-Pernot C, Grosset J, Jarlier V: Selection of a gyrA mutant of Mycobacterium tuberculosis resistant to fluoroquinolones during treatment with ofloxacin. J Infect Dis. 1994 Nov;170(5):1351. - Pubmed
  • Shi R, Zhang J, Li C, Kazumi Y, Sugawara I: Emergence of ofloxacin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by gyrA mutation analysis using denaturing high-pressure liquid chromatography and DNA sequencing. J Clin Microbiol. 2006 Dec;44(12):4566-8. Epub 2006 Oct 11. - Pubmed
DTHybrid score 0.9926
DNA topoisomerase 2-alpha
Name DNA topoisomerase 2-alpha
Gene Name TOP2A
Pharmacological action unknown
Actions inhibitor
References
  • Divo AA, Sartorelli AC, Patton CL, Bia FJ: Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrob Agents Chemother. 1988 Aug;32(8):1182-6. - Pubmed
DTHybrid score 0.7765

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4498

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score 0.3861
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions inhibitor
References
  • Terashi K, Oka M, Soda H, Fukuda M, Kawabata S, Nakatomi K, Shiozawa K, Nakamura T, Tsukamoto K, Noguchi Y, Suenaga M, Tei C, Kohno S: Interactions of ofloxacin and erythromycin with the multidrug resistance protein (MRP) in MRP-overexpressing human leukemia cells. Antimicrob Agents Chemother. 2000 Jun;44(6):1697-700. - Pubmed
DTHybrid score 0.2647
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. - Pubmed
DTHybrid score 0.3777
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inhibitor
References
  • Sasabe H, Tsuji A, Sugiyama Y: Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats. J Pharmacol Exp Ther. 1998 Mar;284(3):1033-9. - Pubmed
DTHybrid score 0.2977
Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions inhibitor
References
  • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
DTHybrid score 0.2363

Predictions


Id Partner name Gene Name Score
6224 DNA gyrase subunit A gyrA 0.9926
886 DNA topoisomerase 4 subunit A parC 0.9507
6226 DNA topoisomerase 4 subunit A parC 0.9507
4512 Cytochrome P450 3A4 CYP3A4 0.2336
1588 Multidrug resistance protein 1 ABCB1 0.2293
4119 Cytochrome P450 2D6 CYP2D6 0.1506
4757 Cytochrome P450 2C9 CYP2C9 0.133
6144 Solute carrier family 22 member 2 SLC22A2 0.1198
4118 Cytochrome P450 3A5 CYP3A5 0.1191
6142 Solute carrier family 22 member 8 SLC22A8 0.1178
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1096
6016 Cytochrome P450 2C19 CYP2C19 0.1046
6145 Solute carrier family 22 member 1 SLC22A1 0.1042
6107 Cytochrome P450 3A7 CYP3A7 0.0954
4924 Cytochrome P450 2C8 CYP2C8 0.0873
6024 Cytochrome P450 1A1 CYP1A1 0.0846
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0774
1024 Solute carrier family 22 member 11 SLC22A11 0.0759
587 Serum albumin ALB 0.0701
6013 Cytochrome P450 2E1 CYP2E1 0.0677
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.065
6147 Solute carrier family 22 member 3 SLC22A3 0.0649
6030 Cytochrome P450 2B6 CYP2B6 0.0647
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0631
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0623
776 Bile salt export pump ABCB11 0.0618
6143 Solute carrier family 22 member 7 SLC22A7 0.0596
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.057
2164 Multidrug resistance-associated protein 4 ABCC4 0.0529
4192 DNA topoisomerase 2-beta TOP2B 0.0515
20 Prostaglandin G/H synthase 1 PTGS1 0.0511
5718 Cytochrome P450 2A6 CYP2A6 0.0507
6137 Multidrug resistance-associated protein 6 ABCC6 0.0501
290 Prostaglandin G/H synthase 2 PTGS2 0.0426
6148 Multidrug resistance-associated protein 7 ABCC10 0.0395
1898 Cytochrome P450 1B1 CYP1B1 0.0383
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0368
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0359
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0336
492 Histamine H1 receptor HRH1 0.0336
738 Monocarboxylate transporter 1 SLC16A1 0.0321
4180 DNA-(apurinic or apyrimidinic site) lyase APEX1 0.0305
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.03
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.029
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0283
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0272
6106 Cytochrome P450 2C18 CYP2C18 0.0264
36 Insulin receptor INSR 0.0258
723 Cytosolic phospholipase A2 PLA2G4A 0.0257
6141 Sodium/bile acid cotransporter SLC10A1 0.0255
633 Penicillin-binding proteins 1A/1B pbpA 0.0253
220 Sodium channel protein type 5 subunit alpha SCN5A 0.025
3947 Xanthine dehydrogenase/oxidase XDH 0.0242
1353 DNA topoisomerase 1 TOP1 0.0235
3552 DNA topoisomerase 1 topA 0.0235
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0228
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0227
161 Tubulin beta chain TUBB 0.0225
312 Tubulin beta chain TUB2 0.0225
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0223
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0219
136 Estrogen receptor ESR1 0.0209
2429 Putrescine-binding periplasmic protein potF 0.0206
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0202
449 Ornithine decarboxylase ODC1 0.0202
318 Alpha-2A adrenergic receptor ADRA2A 0.0201
731 HIV-1 protease HIV-1 protease 0.0199
3941 Amine oxidase [flavin-containing] A MAOA 0.0189
1757 Myeloperoxidase MPO 0.0188
70 Type-1 angiotensin II receptor AGTR1 0.0183
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0181
6136 Multidrug resistance-associated protein 5 ABCC5 0.018
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0176
150 Cationic amino acid transporter 3 SLC7A3 0.0173
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0173
58 Cationic amino acid transporter 4 SLC7A4 0.0173
645 Penicillin-binding protein 1A mrcA 0.0173
5805 Penicillin-binding protein 1A ponA 0.0173
6185 Penicillin-binding protein 1A mrcA 0.0173
6799 Penicillin-binding protein 1A pbpA 0.0173
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0172
2539 Tubulin alpha-1 chain TUBA4A 0.0171
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0166
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0166
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0164
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0163
629 Alpha-2B adrenergic receptor ADRA2B 0.0157
824 Sodium-dependent serotonin transporter SLC6A4 0.0157
3923 Cholinesterase BCHE 0.0156
13 Aminomethyltransferase, mitochondrial AMT 0.0154
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0152
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0152
357 Carbonic anhydrase 2 CA2 0.0149
3811 Cytochrome P450 19A1 CYP19A1 0.0147
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0144
556 Alpha-1A adrenergic receptor ADRA1A 0.0144
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0144
3560 Gentamicin 3'-acetyltransferase aacC1 0.0143
5626 Nucleoside diphosphate kinase B NME2 0.0142
592 Carbonic anhydrase 4 CA4 0.0141
502 5-hydroxytryptamine 2A receptor HTR2A 0.0137
295 Carbonic anhydrase 1 CA1 0.0137
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0136
4604 Liver carboxylesterase 1 CES1 0.0136
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0134
380 Cytochrome P450 17A1 CYP17A1 0.0132
540 Sodium-dependent noradrenaline transporter SLC6A2 0.013
3307 Acriflavine resistance protein B acrB 0.013
378 Alpha-2C adrenergic receptor ADRA2C 0.013
6168 Solute carrier family 22 member 16 SLC22A16 0.0129
373 Transthyretin TTR 0.0129
2472 Voltage-gated potassium channel kcsA 0.0128
6366 Voltage-gated potassium channel kcsA 0.0128
624 Guanidinoacetate N-methyltransferase GAMT 0.0128
275 Arachidonate 5-lipoxygenase ALOX5 0.0127
992 Protein tyrosine kinase 2 beta PTK2B 0.0126
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0125
908 Glutathione S-transferase theta-1 GSTT1 0.0125
273 Apoptosis regulator Bcl-2 BCL2 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
1 Peptidoglycan synthetase ftsI ftsI 0.0121
4155 Peptidoglycan synthetase ftsI ftsI 0.0121
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0118
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
3939 Amine oxidase [flavin-containing] B MAOB 0.0118
338 DNA polymerase UL30 0.0116
379 DNA polymerase UL54 0.0116
697 DNA polymerase ORF28 0.0116
2482 DNA polymerase 43 0.0116
4104 DNA polymerase BALF5 0.0116
6599 HTH-type transcriptional regulator ttgR ttgR 0.0116
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0115
5294 Nucleoside diphosphate kinase A NME1 0.0115
193 Beta-1 adrenergic receptor ADRB1 0.0112
221 Lysyl-tRNA synthetase KARS 0.0112
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0111
831 D(2) dopamine receptor DRD2 0.0111
713 Sodium-dependent dopamine transporter SLC6A3 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
614 Progesterone receptor PGR 0.0109
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0109
3639 Thymidine phosphorylase deoA 0.0108
3936 Thymidine phosphorylase TYMP 0.0108
2443 Azurin azu 0.0108
24 Thymidylate synthase TMP1 0.0108
359 Thymidylate synthase TYMS 0.0108
2626 Thymidylate synthase thyA 0.0108
2729 Thymidylate synthase thyA 0.0108
5352 Thymidylate synthase THYA 0.0108
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0107
558 Solute carrier family 12 member 1 SLC12A1 0.0107
6014 Cytochrome P450 2A13 CYP2A13 0.0107
6151 Monocarboxylate transporter 10 SLC16A10 0.0106
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0106
904 Glutathione S-transferase P GSTP1 0.0105
4120 NADPH--cytochrome P450 reductase POR 0.0105
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0104
543 Penicillin-binding protein 1B mrcB 0.0104
6186 Penicillin-binding protein 1B ponB 0.0104
6822 Penicillin-binding protein 1b pbp1b 0.0104
6844 Penicillin-binding protein 1b pbp1b 0.0104
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0102
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0101
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0101
23 D(1A) dopamine receptor DRD1 0.01
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
6149 Solute carrier family 22 member 10 SLC22A10 0.0099
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0098
5126 Arginase rocF 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
789 Alpha-1D adrenergic receptor ADRA1D 0.0096
303 Diamine acetyltransferase 2 SAT2 0.0096
1317 Spermine synthase SMS 0.0096
623 Spermine oxidase SMOX 0.0096
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0096
474 Acetylcholinesterase ACHE 0.0095
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
766 Beta-2 adrenergic receptor ADRB2 0.0095
7 Nitric oxide synthase, inducible NOS2 0.0093
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
332 Beta-lactamase blaZ 0.0092
2478 Beta-lactamase ampC 0.0092
2613 Beta-lactamase ampC 0.0092
2635 Beta-lactamase ampC 0.0092
2700 Beta-lactamase penP 0.0092
5445 Beta-lactamase blaB 0.0092
6019 Beta-lactamase SHV-7 0.0092
6701 Beta-lactamase cphA 0.0092
869 Estrogen receptor beta ESR2 0.0091
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0091
632 Alpha-1B adrenergic receptor ADRA1B 0.009
131 Synaptic vesicular amine transporter SLC18A2 0.009
29 Tubulin beta-1 chain TUBB1 0.009
885 5-hydroxytryptamine 1B receptor HTR1B 0.009
499 Arginine decarboxylase ADC 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0087
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0087
33 Cystine/glutamate transporter SLC7A11 0.0086
123 Diamine acetyltransferase 1 SAT1 0.0086
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0086
577 Argininosuccinate lyase ASL 0.0085
737 Mineralocorticoid receptor NR3C2 0.0085
468 Cytochrome P450 4A11 CYP4A11 0.0085
834 Arginase-2, mitochondrial ARG2 0.0084
291 Nitric-oxide synthase, endothelial NOS3 0.0084
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0084
740 Argininosuccinate synthase ASS1 0.0084
865 Argininosuccinate synthase ASS1 0.0084
2680 Argininosuccinate synthase argG 0.0084
3194 Argininosuccinate synthase argG 0.0084
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0084
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0083
3917 Methylenetetrahydrofolate reductase MTHFR 0.0083
2016 Dipeptidase 1 DPEP1 0.0082
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0082
6126 Carbonic anhydrase 7 CA7 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
461 Glycine receptor subunit alpha-3 GLRA3 0.0081
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.008
175 Thiamin pyrophosphokinase 1 TPK1 0.008
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.008
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.008
274 Muscarinic acetylcholine receptor M5 CHRM5 0.008
590 5-hydroxytryptamine 2C receptor HTR2C 0.0079
2808 Chloramphenicol acetyltransferase 3 cat3 0.0079
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0079
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0079
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0078
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0078
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0078
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0078
124 Histamine H2 receptor HRH2 0.0078
6167 Organic solute transporter subunit beta OSTB 0.0078
6166 Organic solute transporter subunit alpha OSTA 0.0078
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0078
1629 Transcription factor AP-1 JUN 0.0078
976 Platelet glycoprotein IX GP9 0.0077
725 5-hydroxytryptamine 1D receptor HTR1D 0.0077
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0077
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0076
5923 Microtubule-associated protein tau MAPT 0.0076
5924 Microtubule-associated protein 4 MAP4 0.0076
6228 Nuclear receptor coactivator 1 NCOA1 0.0075
6031 Cytochrome P450 3A43 CYP3A43 0.0075
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0074
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0074
6241 Nuclear receptor coactivator 2 NCOA2 0.0074
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0074
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
551 Carnitine O-acetyltransferase CRAT 0.0073
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0072
22 30S ribosomal protein S4 rpsD 0.0072
6714 30S ribosomal protein S4 rpsD 0.0072
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0072
777 Tumor necrosis factor TNF 0.0072
185 Vasopressin V1a receptor AVPR1A 0.0071
6220 Aryl hydrocarbon receptor AHR 0.0071
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
1852 Microtubule-associated protein 2 MAP2 0.0071
6085 Fatty acid-binding protein, intestinal FABP2 0.007
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.007
322 Vasopressin V2 receptor AVPR2 0.007
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0069
140 30S ribosomal protein S9 rpsI 0.0068
6719 30S ribosomal protein S9 rpsI 0.0068
6725 30S ribosomal protein S9 rpsI 0.0068
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0068
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0068
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0067
146 Androgen receptor AR 0.0067
1650 Heme carrier protein 1 SLC46A1 0.0067
6432 Transporter snf 0.0066
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0066
16 Adenosine A1 receptor ADORA1 0.0066
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0065
844 Epidermal growth factor receptor EGFR 0.0065
638 D(3) dopamine receptor DRD3 0.0065
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0064
6043 Putative G-protein coupled receptor 44 GPR44 0.0063
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
320 5-hydroxytryptamine 1A receptor HTR1A 0.0063
489 Monocarboxylate transporter 2 SLC16A7 0.0063
751 Potassium channel subfamily K member 6 KCNK6 0.0063
3270 Elongation factor G fusA 0.0062
6164 POU domain, class 5, transcription factor 1 POU5F1 0.006
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
341 5-hydroxytryptamine 3 receptor HTR3A 0.006
2320 Thymidine kinase, cytosolic TK1 0.0059
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0059
6067 Penicillin binding protein 2a mecA 0.0058
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0058
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0058
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0058
172 Potassium channel subfamily K member 1 KCNK1 0.0057
788 Creatine kinase M-type CKM 0.0057
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0057
2300 Lysozyme E 0.0056
3633 Lysozyme R 0.0056
5597 Lysozyme 17 0.0056
6146 High affinity copper uptake protein 1 SLC31A1 0.0056
4773 Deoxycytidine kinase DCK 0.0056
183 Vascular endothelial growth factor A VEGFA 0.0056
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0056
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0056
1050 Bile salt sulfotransferase SULT2A1 0.0056
6218 Pannexin-1 PANX1 0.0056
6210 Tubulin delta chain TUBD1 0.0056
6212 Tubulin gamma-1 chain TUBG1 0.0056
6211 Tubulin epsilon chain TUBE1 0.0056
5682 Ribonuclease pancreatic RNASE1 0.0056
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0055
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0055
769 High-affinity choline transporter 1 SLC5A7 0.0055
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0055
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0055
576 Choline O-acetyltransferase CHAT 0.0055
700 Choline dehydrogenase, mitochondrial CHDH 0.0055
861 Choline kinase alpha CHKA 0.0055
3927 Choline transporter-like protein 3 SLC44A3 0.0055
1686 Choline transporter-like protein 1 SLC44A1 0.0055
3922 Phospholipase D2 PLD2 0.0055
3926 Choline transporter-like protein 2 SLC44A2 0.0055
3925 Choline transporter-like protein 4 SLC44A4 0.0055
3924 Phospholipase D1 PLD1 0.0055
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0055
117 Sterol O-acyltransferase 1 SOAT1 0.0054
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0054
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0054
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0054
952 Dipeptidyl peptidase 4 DPP4 0.0054
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0054
2449 Tubulin alpha-3 chain TUBA1A 0.0054
3587 Gastrotropin FABP6 0.0054
465 Calmodulin CALM1 0.0054
714 Glutathione reductase, mitochondrial GSR 0.0053
1178 Adenosine A2a receptor ADORA2A 0.0053
871 Glucocorticoid receptor NR3C1 0.0053
432 D(4) dopamine receptor DRD4 0.0053
896 Glutathione S-transferase Mu 1 GSTM1 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
571 Melatonin receptor type 1A MTNR1A 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
26 Vascular endothelial growth factor receptor 3 FLT4 0.0052
6163 Copper-transporting ATPase 2 ATP7B 0.0051
6165 Copper-transporting ATPase 1 ATP7A 0.0051
860 Nicotinamide N-methyltransferase NNMT 0.0051
1714 Mitogen-activated protein kinase 3 MAPK3 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0051
828 Phenylalanine-4-hydroxylase PAH 0.005
3109 Phenylalanine-4-hydroxylase phhA 0.005
32 Vascular endothelial growth factor receptor 1 FLT1 0.0049
702 UMP-CMP kinase CMPK1 0.0049
4238 50S ribosomal protein L4 rplD 0.0049
5578 50S ribosomal protein L4 rplD 0.0049
6173 50S ribosomal protein L4 rplD 0.0049
6219 50S ribosomal protein L4 rplD 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
293 Gamma-glutamyl hydrolase GGH 0.0048
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0048
1360 Sphingomyelin phosphodiesterase SMPD1 0.0048
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0048
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0048
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0048
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0047
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0047
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0047
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0047
4122 Histone deacetylase 2 HDAC2 0.0047
228 Beta platelet-derived growth factor receptor PDGFRB 0.0046
3810 Catechol O-methyltransferase COMT 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
3932 Glutathione S-transferase A2 GSTA2 0.0045
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0045
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0045
6837 Serine/threonine-protein kinase 17B STK17B 0.0045
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0045
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0045
4237 50S ribosomal protein L22 rplV 0.0045
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0045
2981 Phospholipase A2, membrane associated PLA2G2A 0.0044
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0044
6044 Serum paraoxonase/lactonase 3 PON3 0.0044
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0044
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0043
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0043
504 Mast/stem cell growth factor receptor KIT 0.0043
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
1517 Beta-3 adrenergic receptor ADRB3 0.0042
163 D(1B) dopamine receptor DRD5 0.0042
284 DNA-directed RNA polymerase beta chain rpoB 0.0042
5773 DNA-directed RNA polymerase beta chain rpoB 0.0042
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0041
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0041
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0041
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0041
408 Riboflavin kinase RFK 0.0041
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0041
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0041
6020 Aldehyde oxidase AOX1 0.004
102 DNA topoisomerase I, mitochondrial TOP1MT 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
407 Vascular endothelial growth factor receptor 2 KDR 0.0039
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0039
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0039
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0039
1313 Lactoylglutathione lyase GLO1 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0038
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
5353 Glutamate decarboxylase alpha gadA 0.0037
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0037
6138 Multidrug resistance protein 3 ABCB4 0.0037
5787 Angiopoietin-1 receptor TEK 0.0037
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0037
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0037
511 5-hydroxytryptamine 1F receptor HTR1F 0.0037
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0036
244 Angiotensin-converting enzyme ACE 0.0036
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0036
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0035
6131 Carbonic anhydrase 14 CA14 0.0035
164 Histamine H4 receptor HRH4 0.0035
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0035
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0035
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0035
1074 Urokinase-type plasminogen activator PLAU 0.0035
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0035
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
5818 Folate receptor alpha FOLR1 0.0035
6042 Prostaglandin reductase 2 PTGR2 0.0034
2599 Tyrosine-protein kinase HCK HCK 0.0034
76 Nitric-oxide synthase, brain NOS1 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
1341 Histamine H3 receptor HRH3 0.0034
712 Tubulin alpha chain TUB1 0.0034
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0034
165 FL cytokine receptor FLT3 0.0034
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
260 Cytochrome P450 51 ERG11 0.0033
761 Cytochrome P450 51 ERG11 0.0033
3163 Cytochrome P450 51 cyp51 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0032
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0032
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0032
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0032
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0032
2021 Thrombomodulin THBD 0.0031
1039 Histone deacetylase 9 HDAC9 0.0031
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
1192 Sulfotransferase 1A1 SULT1A1 0.0031
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
756 Sex hormone-binding globulin SHBG 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
818 50S ribosomal protein L10 rplJ 0.003
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
173 Toll-like receptor 7 TLR7 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.003
654 Flavin reductase BLVRB 0.0029
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0029
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0029
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0028
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
921 Glutamate receptor 2 GRIA2 0.0028
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0028
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0028
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
1867 Major prion protein PRNP 0.0028
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0028
436 5-hydroxytryptamine 2B receptor HTR2B 0.0028
365 Dihydrofolate reductase DHFR 0.0028
2381 Dihydrofolate reductase DFR1 0.0028
2833 Dihydrofolate reductase Not Available 0.0028
2931 Dihydrofolate reductase folA 0.0028
3544 Dihydrofolate reductase folA 0.0028
3682 Dihydrofolate reductase folA 0.0028
6642 Dihydrofolate reductase folA 0.0028
6756 Dihydrofolate reductase dfrA 0.0028
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0028
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0027
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0027
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0027
1025 Aquaporin-1 AQP1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
1569 G1/S-specific cyclin-D1 CCND1 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0026
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
4203 Histamine N-methyltransferase HNMT 0.0026
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0026
94 5-hydroxytryptamine 4 receptor HTR4 0.0025
130 Prostacyclin synthase PTGIS 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
1760 Aminopeptidase N ANPEP 0.0025
6843 Aminopeptidase N pepN 0.0025
5880 Thrombopoietin receptor MPL 0.0025
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0025
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0025
2391 Ferrochelatase hemH 0.0025
6502 Ferrochelatase DKFZp686P18130 0.0025
1591 Ferrochelatase, mitochondrial FECH 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
6207 30S ribosomal protein S14 rpsN 0.0024
6209 30S ribosomal protein S19 rpsS 0.0024
6712 30S ribosomal protein S19 rpsS 0.0024
6726 30S ribosomal protein S19 rpsS 0.0024
459 Retinoic acid receptor RXR-alpha RXRA 0.0024
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
6070 Nischarin NISCH 0.0024
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0024
6102 Arylamine N-acetyltransferase 2 NAT2 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
153 Dopamine beta-hydroxylase DBH 0.0023
3957 Adenosine deaminase ADA 0.0023
4760 Mll3241 protein mll3241 0.0023
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0023
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
1792 Tissue-type plasminogen activator PLAT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0021
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0021
6493 Cytochrome c oxidase subunit 6C COX6C 0.0021
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0021
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0021
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0021
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0021
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0021
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0021
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0021
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0021
6559 Cytochrome c oxidase subunit 2 ctaC 0.0021
6669 Cytochrome c oxidase subunit 2 ctaC 0.0021
3426 Glutamine synthetase glnA 0.0021
3987 Glutamine synthetase GLUL 0.0021
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0021
6558 Cytochrome c oxidase subunit 1 ctaD 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
6033 High affinity interleukin-8 receptor A CXCR1 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
527 Prostacyclin receptor PTGIR 0.0021
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0021
822 Aldose reductase AKR1B1 0.0021
672 Prostaglandin F2-alpha receptor PTGFR 0.002
634 Squalene monooxygenase SQLE 0.002
7196 Squalene monooxygenase ERG1 0.002
1820 Beta-nerve growth factor NGF 0.002
1630 Integrin beta-2 ITGB2 0.002
2540 Choloylglycine hydrolase cbh 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
716 5-hydroxytryptamine 7 receptor HTR7 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
1654 Interleukin-1 beta IL1B 0.0019
517 Alcohol dehydrogenase 1C ADH1C 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
6501 Fatty acid-binding protein, liver FABP1 0.0019
122 P2Y purinoceptor 12 P2RY12 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
1176 Mitogen-activated protein kinase 1 MAPK1 0.0018
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
1256 5-hydroxytryptamine 6 receptor HTR6 0.0017
1648 Elastin ELN 0.0017
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0017
1928 Leukotriene C4 synthase LTC4S 0.0017
4034 Glutaredoxin-1 GLRX 0.0017
910 Epididymal secretory glutathione peroxidase GPX5 0.0017
4037 Hypothetical protein GPX1 0.0017
4297 Hypothetical protein SP_1951 0.0017
4521 Hypothetical protein BC_2969 0.0017
4540 Hypothetical protein TM_1070 0.0017
4555 Hypothetical protein MT1739 0.0017
4569 Hypothetical protein mshD 0.0017
4578 Hypothetical protein PA3270 0.0017
4747 Hypothetical protein PA3967 0.0017
5177 Hypothetical protein TM_0096 0.0017
5194 Hypothetical protein PA1204 0.0017
5240 Hypothetical protein Rv2991 0.0017
5370 Hypothetical protein TM_1158 0.0017
5710 Hypothetical protein Tb927.5.1360 0.0017
4029 Microsomal glutathione S-transferase 3 MGST3 0.0017
4036 Glutathione peroxidase 6 GPX6 0.0017
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0017
4032 Microsomal glutathione S-transferase 1 MGST1 0.0017
903 Glutathione S-transferase A5 GSTA5 0.0017
4040 Glutathione peroxidase 7 GPX7 0.0017
907 Glutathione peroxidase 2 GPX2 0.0017
900 Glutathione S-transferase A4 GSTA4 0.0017
911 Glutathione peroxidase 3 GPX3 0.0017
906 Glutathione peroxidase 1 GPX1 0.0017
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0017
4035 Glutathione S-transferase Mu 5 GSTM5 0.0017
4042 Glutathione transferase omega-2 GSTO2 0.0017
4038 Glutathione peroxidase 4 GPX4 0.0017
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0017
4033 S-formylglutathione hydrolase ESD 0.0017
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
1656 CYP2B protein CYP2B 0.0017
3809 Estrogen-related receptor gamma ESRRG 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
1830 5'-nucleotidase NT5E 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0016
1243 Cathepsin D CTSD 0.0016
1010 Cytochrome P450 51A1 CYP51A1 0.0016
427 Substance-P receptor TACR1 0.0016
3319 Hydroxyacylglutathione hydrolase HAGH 0.0016
898 Glutathione S-transferase A3 GSTA3 0.0016
6500 Phospholipase A2 PLA2G1B 0.0016
897 Glutathione S-transferase kappa 1 GSTK1 0.0015
2236 Casein kinase II subunit alpha CSNK2A1 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
494 Caspase-1 CASP1 0.0015
1275 Estrogen sulfotransferase SULT1E1 0.0015
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0015
909 Maleylacetoacetate isomerase GSTZ1 0.0015
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0015
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0015
899 Glutathione S-transferase Mu 3 GSTM3 0.0015
905 Glutathione transferase omega-1 GSTO1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
572 Integrin alpha-L ITGAL 0.0015
1507 Cytochrome c CYCS 0.0015
1405 Thiopurine S-methyltransferase TPMT 0.0015
4041 Microsomal glutathione S-transferase 2 MGST2 0.0015
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0014
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0014
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0014
484 Tyrosine-protein kinase ABL2 ABL2 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
4217 Telomerase reverse transcriptase TERT 0.0014
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0014
3760 Penicillin-binding protein 5 precursor dacA 0.0014
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0014
2165 Glutathione S-transferase Mu 2 GSTM2 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
847 Mu-type opioid receptor OPRM1 0.0014
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0013
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
207 Glutathione synthetase GSS 0.0013
5269 Glutathione synthetase gshB 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0013
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
901 Glutathione S-transferase Mu 4 GSTM4 0.0013
2077 Caspase-3 CASP3 0.0013
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0013
696 Kappa-type opioid receptor OPRK1 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0012
819 Penicillin-binding protein 4 dacB 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
4311 tRNA TRDMT1 0.0012
4325 tRNA trmD 0.0012
4328 tRNA trmD 0.0012
518 Peroxidase/catalase T katG 0.0012
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0012
4031 Glutathione S-transferase A1 GSTA1 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
563 Thyroid peroxidase TPO 0.0011
340 Apoptotic protease-activating factor 1 APAF1 0.0011
84 Nuclear receptor 0B1 NR0B1 0.0011
467 Delta-type opioid receptor OPRD1 0.0011
239 Coagulation factor X F10 0.001
469 Annexin A1 ANXA1 0.001
997 Protein kinase C beta type PRKCB 0.001
564 Cellular retinoic acid-binding protein 1 CRABP1 0.001
825 Arsenical pump-driving ATPase ASNA1 0.001
3435 Arsenical pump-driving ATPase arsA 0.001
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.001
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.001
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.001
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.001
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.001
733 Activin receptor type 1B ACVR1B 0.001
154 AFG3-like protein 2 AFG3L2 0.001
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.001
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.001
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.001
395 ALK tyrosine kinase receptor Not Available 0.001
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
859 Cellular retinoic acid-binding protein 2 CRABP2 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
823 Fibroblast growth factor receptor 2 FGFR2 0.001
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
6182 Cytochrome P450 2J2 CYP2J2 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
780 Retinoic acid receptor RXR-gamma RXRG 0.0009
229 Retinoic acid receptor beta RARB 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0009
292 Activin receptor type-1 ACVR1 0.0009
849 Activated CDC42 kinase 1 TNK2 0.0009
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0009
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0009
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0009
297 Adenylate cyclase type 1 ADCY1 0.0009
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0008
528 5-hydroxytryptamine 1E receptor HTR1E 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0008
3830 Calreticulin CALR 0.0008
162 Retinoic acid receptor gamma-1 RARG 0.0008
1618 High affinity nerve growth factor receptor NTRK1 0.0008
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
811 Translocator protein TSPO 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
1374 Natriuretic peptides B NPPB 0.0008
1827 Gap junction alpha-1 protein GJA1 0.0008
1908 Vascular cell adhesion protein 1 VCAM1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
6021 Adenosine kinase ADK 0.0007
661 ADP/ATP translocase 1 SLC25A4 0.0007
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
705 Glutamate receptor 1 GRIA1 0.0007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0006
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1864 RET proto-oncogene RET 0.0006
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0006
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0006
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0006
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0006
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0006
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0006
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
798 Osteocalcin BGLAP 0.0005
5934 Cytochrome P450 26A1 CYP26A1 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
369 Coagulation factor VII F7 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0005
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0004
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
54 Prothrombin F2 0.0003
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