DT-Web: DB01202

Identification

Name

Levetiracetam

Accession Number

DB01202 (APRD01068)

Type

small molecule

Description

Levetiracetam is an anticonvulsant medication used to treat epilepsy. Levetiracetam may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity. Levetiracetam binds to the synaptic vesicle protein SV2A, which is thought to be involved in the regulation of vesicle exocytosis. Although the molecular significance of levetiracetam binding to synaptic vesicle protein SV2A is not understood, levetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone mice.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

170.209

Groups

approved

Monoisotopic Weight

170.105527702

Pharmacology

Indication

Used as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy.

Mechanism of action

The precise mechanism(s) by which levetiracetam exerts its antiepileptic effect is unknown. The antiepileptic activity of levetiracetam was assessed in a number of animal models of epileptic seizures. Levetiracetam did not inhibit single seizures induced by maximal stimulation with electrical current or different chemoconvulsants and showed only minimal activity in submaximal stimulation and in threshold tests. Protection was observed, however, against secondarily generalized activity from focal seizures induced by pilocarpine and kainic acid, two chemoconvulsants that induce seizures that mimic some features of human complex partial seizures with secondary generalization. Levetiracetam also displayed inhibitory properties in the kindling model in rats, another model of human complex partial seizures, both during kindling development and in the fully kindled state. The predictive value of these animal models for specific types of human epilepsy is uncertain. Levetiracetam is thought to stimulate synaptic vesicle protein 2A (SV2A), inhibiting neurotransmitter release.

Absorption

Rapidly and almost completely absorbed after oral administration (99%). Peak plasma concentrations occurring in about an hour following oral administration in fasted subjects.

Protein binding

Very low (<10%)

Biotransformation

The major metabolic pathway of levetiracetam (24% of dose) is an enzymatic hydrolysis of the acetamide group. No CYP450 metabolism detected.

Route of elimination

Sixty-six percent (66%) of the dose is renally excreted unchanged. The metabolites have no known pharmacological activity and are renally excreted. The mechanism of excretion is glomerular filtration with subsequent partial tubular reabsorption.

Toxicity

Side effects include aggression, agitation, coma, drowsiness, reduced consciousness, slowed breathing

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Carbamazepine	Concomitant therapy may results in additive adverse CNS effects.
Triprolidine	The CNS depressants, Triprolidine and Levetiracetam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.

Food Interactions

Take without regard to meals. Food does not affect bioavailabilty.

Synaptic vesicle glycoprotein 2A
Name	Synaptic vesicle glycoprotein 2A
Gene Name	SV2A
Pharmacological action	yes
Actions	agonist
References	Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B: The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9861-6. Epub 2004 Jun 21. - Pubmed Stahl SM: Psychopharmacology of anticonvulsants: levetiracetam as a synaptic vesicle protein modulator. J Clin Psychiatry. 2004 Sep;65(9):1162-3. - Pubmed Lambeng N, Grossmann M, Chatelain P, Fuks B: Solubilization and immunopurification of rat brain synaptic vesicle protein 2A with maintained binding properties. Neurosci Lett. 2006 May 1;398(1-2):107-12. Epub 2006 Jan 24. - Pubmed Gillard M, Chatelain P, Fuks B: Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein. Eur J Pharmacol. 2006 Apr 24;536(1-2):102-8. Epub 2006 Mar 10. - Pubmed Newton HB, Dalton J, Goldlust S, Pearl D: Retrospective analysis of the efficacy and tolerability of levetiracetam in patients with metastatic brain tumors. J Neurooncol. 2007 Sep;84(3):293-6. Epub 2007 Apr 13. - Pubmed Johannessen Landmark C: Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy. CNS Drugs. 2008;22(1):27-47. - Pubmed De Smedt T, Raedt R, Vonck K, Boon P: Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data. CNS Drug Rev. 2007 Spring;13(1):43-56. - Pubmed
DTHybrid score	0.591
Voltage-dependent N-type calcium channel subunit alpha-1B
Name	Voltage-dependent N-type calcium channel subunit alpha-1B
Gene Name	CACNA1B
Pharmacological action	yes
Actions	inhibitor
References	De Smedt T, Raedt R, Vonck K, Boon P: Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data. CNS Drug Rev. 2007 Spring;13(1):43-56. - Pubmed Lukyanetz EA, Shkryl VM, Kostyuk PG: Selective blockade of N-type calcium channels by levetiracetam. Epilepsia. 2002 Jan;43(1):9-18. - Pubmed
DTHybrid score	0.411

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Loscher W: Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb;52(2):333-46. Epub 2006 Oct 10. - Pubmed Luna-Tortos C, Fedrowitz M, Loscher W: Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology. 2008 Dec;55(8):1364-75. Epub 2008 Sep 11. - Pubmed
DTHybrid score	0.3594
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate
References	Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Loscher W: Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb;52(2):333-46. Epub 2006 Oct 10. - Pubmed
DTHybrid score	0.3104

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.1038
4118	Cytochrome P450 3A5	CYP3A5	0.0644
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0592
4924	Cytochrome P450 2C8	CYP2C8	0.056
4757	Cytochrome P450 2C9	CYP2C9	0.0547
4119	Cytochrome P450 2D6	CYP2D6	0.0538
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0512
6107	Cytochrome P450 3A7	CYP3A7	0.049
4200	Cytochrome P450 1A2	CYP1A2	0.0483
862	Multidrug resistance-associated protein 1	ABCC1	0.0462
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0453
6016	Cytochrome P450 2C19	CYP2C19	0.0446
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0441
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0415
6030	Cytochrome P450 2B6	CYP2B6	0.0396
16	Adenosine A1 receptor	ADORA1	0.039
6145	Solute carrier family 22 member 1	SLC22A1	0.0385
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0381
6144	Solute carrier family 22 member 2	SLC22A2	0.0353
776	Bile salt export pump	ABCB11	0.0353
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.035
6070	Nischarin	NISCH	0.0337
2164	Multidrug resistance-associated protein 4	ABCC4	0.0286
6147	Solute carrier family 22 member 3	SLC22A3	0.0272
6024	Cytochrome P450 1A1	CYP1A1	0.0268
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0262
587	Serum albumin	ALB	0.0258
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0255
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0253
118	Organic cation/carnitine transporter 2	SLC22A5	0.0214
378	Alpha-2C adrenergic receptor	ADRA2C	0.0211
6148	Multidrug resistance-associated protein 7	ABCC10	0.0205
1729	Solute carrier family 22 member 6	SLC22A6	0.0198
6013	Cytochrome P450 2E1	CYP2E1	0.0195
5718	Cytochrome P450 2A6	CYP2A6	0.0191
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0189
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0189
70	Type-1 angiotensin II receptor	AGTR1	0.0186
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0185
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0184
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0184
817	DNA topoisomerase 2-alpha	TOP2A	0.0174
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0171
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0168
136	Estrogen receptor	ESR1	0.0156
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
6141	Sodium/bile acid cotransporter	SLC10A1	0.0152
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0151
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.015
477	DNA topoisomerase 4 subunit A	parC	0.0149
886	DNA topoisomerase 4 subunit A	parC	0.0149
6226	DNA topoisomerase 4 subunit A	parC	0.0149
404	DNA gyrase subunit A	gyrA	0.0146
6224	DNA gyrase subunit A	gyrA	0.0146
6142	Solute carrier family 22 member 8	SLC22A8	0.0146
1898	Cytochrome P450 1B1	CYP1B1	0.0145
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0135
6137	Multidrug resistance-associated protein 6	ABCC6	0.0134
824	Sodium-dependent serotonin transporter	SLC6A4	0.0132
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0125
6143	Solute carrier family 22 member 7	SLC22A7	0.0124
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.012
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0117
833	Organic cation/carnitine transporter 1	SLC22A4	0.0114
6106	Cytochrome P450 2C18	CYP2C18	0.0111
2443	Azurin	azu	0.0108
556	Alpha-1A adrenergic receptor	ADRA1A	0.0108
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0107
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0107
20	Prostaglandin G/H synthase 1	PTGS1	0.0105
871	Glucocorticoid receptor	NR3C1	0.0105
614	Progesterone receptor	PGR	0.0104
3923	Cholinesterase	BCHE	0.0102
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0101
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0101
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.01
185	Vasopressin V1a receptor	AVPR1A	0.0096
4604	Liver carboxylesterase 1	CES1	0.0095
322	Vasopressin V2 receptor	AVPR2	0.0093
193	Beta-1 adrenergic receptor	ADRB1	0.0093
1024	Solute carrier family 22 member 11	SLC22A11	0.0092
731	HIV-1 protease	HIV-1 protease	0.009
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.009
3811	Cytochrome P450 19A1	CYP19A1	0.0089
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0088
831	D(2) dopamine receptor	DRD2	0.0087
295	Carbonic anhydrase 1	CA1	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
6136	Multidrug resistance-associated protein 5	ABCC5	0.0081
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0081
492	Histamine H1 receptor	HRH1	0.0081
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0079
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0078
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0078
290	Prostaglandin G/H synthase 2	PTGS2	0.0077
24	Thymidylate synthase	TMP1	0.0075
359	Thymidylate synthase	TYMS	0.0075
2626	Thymidylate synthase	thyA	0.0075
2729	Thymidylate synthase	thyA	0.0075
5352	Thymidylate synthase	THYA	0.0075
738	Monocarboxylate transporter 1	SLC16A1	0.0074
161	Tubulin beta chain	TUBB	0.0073
312	Tubulin beta chain	TUB2	0.0073
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0073
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0073
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0072
2417	Chloramphenicol acetyltransferase	cat	0.0071
3278	Chloramphenicol acetyltransferase	cat	0.0071
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0071
766	Beta-2 adrenergic receptor	ADRB2	0.007
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.007
908	Glutathione S-transferase theta-1	GSTT1	0.0067
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0066
1192	Sulfotransferase 1A1	SULT1A1	0.0066
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0065
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0065
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0064
4120	NADPH--cytochrome P450 reductase	POR	0.0064
1353	DNA topoisomerase 1	TOP1	0.0064
3552	DNA topoisomerase 1	topA	0.0064
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0063
244	Angiotensin-converting enzyme	ACE	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
275	Arachidonate 5-lipoxygenase	ALOX5	0.0063
3270	Elongation factor G	fusA	0.0062
904	Glutathione S-transferase P	GSTP1	0.0062
504	Mast/stem cell growth factor receptor	KIT	0.0061
2808	Chloramphenicol acetyltransferase 3	cat3	0.0061
26	Vascular endothelial growth factor receptor 3	FLT4	0.0059
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0059
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0059
3947	Xanthine dehydrogenase/oxidase	XDH	0.0058
632	Alpha-1B adrenergic receptor	ADRA1B	0.0058
737	Mineralocorticoid receptor	NR3C2	0.0057
32	Vascular endothelial growth factor receptor 1	FLT1	0.0057
1852	Microtubule-associated protein 2	MAP2	0.0056
777	Tumor necrosis factor	TNF	0.0056
1629	Transcription factor AP-1	JUN	0.0055
465	Calmodulin	CALM1	0.0055
260	Cytochrome P450 51	ERG11	0.0054
761	Cytochrome P450 51	ERG11	0.0054
3163	Cytochrome P450 51	cyp51	0.0054
5626	Nucleoside diphosphate kinase B	NME2	0.0054
468	Cytochrome P450 4A11	CYP4A11	0.0053
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0053
2449	Tubulin alpha-3 chain	TUBA1A	0.0052
6182	Cytochrome P450 2J2	CYP2J2	0.0052
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0052
29	Tubulin beta-1 chain	TUBB1	0.0052
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0051
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0051
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0051
320	5-hydroxytryptamine 1A receptor	HTR1A	0.005
789	Alpha-1D adrenergic receptor	ADRA1D	0.005
844	Epidermal growth factor receptor	EGFR	0.005
6163	Copper-transporting ATPase 2	ATP7B	0.005
6165	Copper-transporting ATPase 1	ATP7A	0.005
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0049
869	Estrogen receptor beta	ESR2	0.0049
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0049
407	Vascular endothelial growth factor receptor 2	KDR	0.0049
146	Androgen receptor	AR	0.0048
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0048
23	D(1A) dopamine receptor	DRD1	0.0048
847	Mu-type opioid receptor	OPRM1	0.0048
6146	High affinity copper uptake protein 1	SLC31A1	0.0047
461	Glycine receptor subunit alpha-3	GLRA3	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0046
318	Alpha-2A adrenergic receptor	ADRA2A	0.0045
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0045
896	Glutathione S-transferase Mu 1	GSTM1	0.0045
165	FL cytokine receptor	FLT3	0.0044
124	Histamine H2 receptor	HRH2	0.0044
5923	Microtubule-associated protein tau	MAPT	0.0044
5924	Microtubule-associated protein 4	MAP4	0.0044
952	Dipeptidyl peptidase 4	DPP4	0.0044
5294	Nucleoside diphosphate kinase A	NME1	0.0044
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0043
467	Delta-type opioid receptor	OPRD1	0.0043
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0043
273	Apoptosis regulator Bcl-2	BCL2	0.0042
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0042
131	Synaptic vesicular amine transporter	SLC18A2	0.0041
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0041
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0041
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0041
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.004
436	5-hydroxytryptamine 2B receptor	HTR2B	0.004
696	Kappa-type opioid receptor	OPRK1	0.004
474	Acetylcholinesterase	ACHE	0.004
6085	Fatty acid-binding protein, intestinal	FABP2	0.0039
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0039
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0039
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0038
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0038
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0038
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0038
380	Cytochrome P450 17A1	CYP17A1	0.0038
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0038
2232	Interleukin-5	IL5	0.0037
1593	Mucin-2	MUC2	0.0037
4192	DNA topoisomerase 2-beta	TOP2B	0.0037
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0037
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0037
1757	Myeloperoxidase	MPO	0.0036
122	P2Y purinoceptor 12	P2RY12	0.0036
2539	Tubulin alpha-1 chain	TUBA4A	0.0036
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0036
6149	Solute carrier family 22 member 10	SLC22A10	0.0036
1569	G1/S-specific cyclin-D1	CCND1	0.0036
1650	Heme carrier protein 1	SLC46A1	0.0036
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0035
1760	Aminopeptidase N	ANPEP	0.0034
6843	Aminopeptidase N	pepN	0.0034
3941	Amine oxidase [flavin-containing] A	MAOA	0.0033
117	Sterol O-acyltransferase 1	SOAT1	0.0033
6167	Organic solute transporter subunit beta	OSTB	0.0033
6166	Organic solute transporter subunit alpha	OSTA	0.0033
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0033
33	Cystine/glutamate transporter	SLC7A11	0.0033
6211	Tubulin epsilon chain	TUBE1	0.0032
6210	Tubulin delta chain	TUBD1	0.0032
6212	Tubulin gamma-1 chain	TUBG1	0.0032
3939	Amine oxidase [flavin-containing] B	MAOB	0.0032
2499	Tubulin beta-2C chain	TUBB2C	0.0031
1123	Eosinophil cationic protein	RNASE3	0.0031
702	UMP-CMP kinase	CMPK1	0.0031
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0031
638	D(3) dopamine receptor	DRD3	0.0031
6031	Cytochrome P450 3A43	CYP3A43	0.0031
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0031
2599	Tyrosine-protein kinase HCK	HCK	0.003
756	Sex hormone-binding globulin	SHBG	0.003
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.003
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.003
590	5-hydroxytryptamine 2C receptor	HTR2C	0.003
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.003
1714	Mitogen-activated protein kinase 3	MAPK3	0.0029
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0029
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0029
683	Potassium transporter	GK0582	0.0029
629	Alpha-2B adrenergic receptor	ADRA2B	0.0029
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0029
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0028
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0028
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0028
6138	Multidrug resistance protein 3	ABCB4	0.0028
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0027
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0027
4237	50S ribosomal protein L22	rplV	0.0027
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0027
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0027
489	Monocarboxylate transporter 2	SLC16A7	0.0026
3587	Gastrotropin	FABP6	0.0026
818	50S ribosomal protein L10	rplJ	0.0026
1630	Integrin beta-2	ITGB2	0.0026
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0026
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0026
6837	Serine/threonine-protein kinase 17B	STK17B	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
4773	Deoxycytidine kinase	DCK	0.0026
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0025
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0024
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0024
319	Opioid receptor, sigma 1	OPRS1	0.0024
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0024
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0024
1176	Mitogen-activated protein kinase 1	MAPK1	0.0024
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0024
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0024
4103	Proteasome subunit beta type 2	PSMB2	0.0023
4102	Proteasome subunit beta type 5	PSMB5	0.0023
4101	Proteasome subunit beta type 1	PSMB1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0023
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0023
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0023
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0023
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0023
713	Sodium-dependent dopamine transporter	SLC6A3	0.0023
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0023
373	Transthyretin	TTR	0.0023
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0023
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0023
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0023
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0023
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0022
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0022
716	5-hydroxytryptamine 7 receptor	HTR7	0.0021
469	Annexin A1	ANXA1	0.0021
6044	Serum paraoxonase/lactonase 3	PON3	0.0021
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0021
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0021
558	Solute carrier family 12 member 1	SLC12A1	0.002
7	Nitric oxide synthase, inducible	NOS2	0.002
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.002
1656	CYP2B protein	CYP2B	0.002
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.002
572	Integrin alpha-L	ITGAL	0.002
3868	Calcineurin subunit B isoform 2	PPP3R2	0.002
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.002
2107	Microtubule-associated protein 1A	MAP1A	0.002
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0019
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0019
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0019
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0019
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0019
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0019
365	Dihydrofolate reductase	DHFR	0.0019
2381	Dihydrofolate reductase	DFR1	0.0019
2833	Dihydrofolate reductase	Not Available	0.0019
2931	Dihydrofolate reductase	folA	0.0019
3544	Dihydrofolate reductase	folA	0.0019
3682	Dihydrofolate reductase	folA	0.0019
6642	Dihydrofolate reductase	folA	0.0019
6756	Dihydrofolate reductase	dfrA	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
239	Coagulation factor X	F10	0.0019
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0019
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0019
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0019
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0018
4122	Histone deacetylase 2	HDAC2	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0017
594	Thyroxine-binding globulin	SERPINA7	0.0017
6218	Pannexin-1	PANX1	0.0017
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0017
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0017
768	FK506-binding protein 1A	FKBP1A	0.0017
1313	Lactoylglutathione lyase	GLO1	0.0017
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0017
751	Potassium channel subfamily K member 6	KCNK6	0.0017
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0016
6824	Tyrosine-protein kinase Lyn	LYN	0.0016
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
3809	Estrogen-related receptor gamma	ESRRG	0.0016
484	Tyrosine-protein kinase ABL2	ABL2	0.0016
3810	Catechol O-methyltransferase	COMT	0.0016
5300	Antigen peptide transporter 1	TAP1	0.0016
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0016
758	Thyroid hormone receptor alpha	THRA	0.0016
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0015
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0015
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0015
6755	Poliovirus receptor	PVR	0.0015
172	Potassium channel subfamily K member 1	KCNK1	0.0015
5818	Folate receptor alpha	FOLR1	0.0015
1517	Beta-3 adrenergic receptor	ADRB3	0.0015
6220	Aryl hydrocarbon receptor	AHR	0.0015
6042	Prostaglandin reductase 2	PTGR2	0.0015
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0015
340	Apoptotic protease-activating factor 1	APAF1	0.0015
84	Nuclear receptor 0B1	NR0B1	0.0015
605	Fumarate reductase flavoprotein subunit	frdA	0.0015
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0015
3673	Fumarate reductase flavoprotein subunit	fccA	0.0015
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0015
6549	Fumarate reductase flavoprotein subunit	frdA	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1770	Phospholipase C	PLCL1	0.0015
2841	Phospholipase C	plc	0.0015
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0015
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0014
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0014
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0014
1178	Adenosine A2a receptor	ADORA2A	0.0014
6168	Solute carrier family 22 member 16	SLC22A16	0.0014
357	Carbonic anhydrase 2	CA2	0.0014
2391	Ferrochelatase	hemH	0.0014
6502	Ferrochelatase	DKFZp686P18130	0.0014
1591	Ferrochelatase, mitochondrial	FECH	0.0014
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
346	Thyroid hormone receptor beta-1	THRB	0.0014
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0014
6043	Putative G-protein coupled receptor 44	GPR44	0.0014
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0014
3932	Glutathione S-transferase A2	GSTA2	0.0014
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
284	DNA-directed RNA polymerase beta chain	rpoB	0.0013
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0013
293	Gamma-glutamyl hydrolase	GGH	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
1010	Cytochrome P450 51A1	CYP51A1	0.0013
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0013
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0013
6432	Transporter	snf	0.0013
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0012
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0012
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0012
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0012
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0012
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0012
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0012
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0012
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0012
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0012
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0012
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0012
6559	Cytochrome c oxidase subunit 2	ctaC	0.0012
6669	Cytochrome c oxidase subunit 2	ctaC	0.0012
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0012
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0012
6558	Cytochrome c oxidase subunit 1	ctaD	0.0012
3856	Fibroblast growth factor receptor 3	FGFR3	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0012
694	Matrix protein 2	M	0.0012
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0012
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0012
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0012
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0012
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0012
292	Activin receptor type-1	ACVR1	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0012
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0012
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0012
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0012
6859	Protein S100-A4	S100A4	0.0012
432	D(4) dopamine receptor	DRD4	0.0012
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0012
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
2540	Choloylglycine hydrolase	cbh	0.0011
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
2112	Toll-like receptor 9	TLR9	0.0011
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
6459	Glycodelin	PAEP	0.0011
291	Nitric-oxide synthase, endothelial	NOS3	0.0011
1618	High affinity nerve growth factor receptor	NTRK1	0.0011
232	Corticosteroid-binding globulin	SERPINA6	0.0011
6501	Fatty acid-binding protein, liver	FABP1	0.0011
427	Substance-P receptor	TACR1	0.0011
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0011
144	Hemoglobin subunit alpha	HBA1	0.001
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.001
106	Cannabinoid receptor 2	CNR2	0.001
6174	50S ribosomal protein L32	rpmF	0.001
4203	Histamine N-methyltransferase	HNMT	0.001
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.001
811	Translocator protein	TSPO	0.001
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
740	Argininosuccinate synthase	ASS1	0.001
865	Argininosuccinate synthase	ASS1	0.001
2680	Argininosuccinate synthase	argG	0.001
3194	Argininosuccinate synthase	argG	0.001
723	Cytosolic phospholipase A2	PLA2G4A	0.001
68	Cannabinoid receptor 1	CNR1	0.001
199	Monocarboxylate transporter 8	SLC16A2	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
76	Nitric-oxide synthase, brain	NOS1	0.001
3957	Adenosine deaminase	ADA	0.0009
661	ADP/ATP translocase 1	SLC25A4	0.0009
6021	Adenosine kinase	ADK	0.0009
936	Ephrin type-A receptor 2	EPHA2	0.0009
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0009
3611	Cytidine deaminase	cdd	0.0009
3707	Cytidine deaminase	cdd	0.0009
4211	Cytidine deaminase	CDA	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0009
1291	cAMP response element-binding protein	CREB1	0.0009
1525	Heparin-binding growth factor 2	FGF2	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
6020	Aldehyde oxidase	AOX1	0.0009
2240	Cell division protein kinase 2	CDK2	0.0009
6500	Phospholipase A2	PLA2G1B	0.0009
4210	Toll-like receptor 4	TLR4	0.0009
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
54	Prothrombin	F2	0.0009
1262	Corticotropin-lipotropin	POMC	0.0009
5787	Angiopoietin-1 receptor	TEK	0.0008
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0008
823	Fibroblast growth factor receptor 2	FGFR2	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0008
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0008
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
780	Retinoic acid receptor RXR-gamma	RXRG	0.0008
517	Alcohol dehydrogenase 1C	ADH1C	0.0008
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
921	Glutamate receptor 2	GRIA2	0.0007
459	Retinoic acid receptor RXR-alpha	RXRA	0.0007
88	Retinoic acid receptor RXR-beta	RXRB	0.0007
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0007
4034	Glutaredoxin-1	GLRX	0.0007
910	Epididymal secretory glutathione peroxidase	GPX5	0.0007
903	Glutathione S-transferase A5	GSTA5	0.0007
4037	Hypothetical protein	GPX1	0.0007
4297	Hypothetical protein	SP_1951	0.0007
4521	Hypothetical protein	BC_2969	0.0007
4540	Hypothetical protein	TM_1070	0.0007
4555	Hypothetical protein	MT1739	0.0007
4569	Hypothetical protein	mshD	0.0007
4578	Hypothetical protein	PA3270	0.0007
4747	Hypothetical protein	PA3967	0.0007
5177	Hypothetical protein	TM_0096	0.0007
5194	Hypothetical protein	PA1204	0.0007
5240	Hypothetical protein	Rv2991	0.0007
5370	Hypothetical protein	TM_1158	0.0007
5710	Hypothetical protein	Tb927.5.1360	0.0007
1928	Leukotriene C4 synthase	LTC4S	0.0007
4029	Microsomal glutathione S-transferase 3	MGST3	0.0007
4032	Microsomal glutathione S-transferase 1	MGST1	0.0007
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0007
4040	Glutathione peroxidase 7	GPX7	0.0007
907	Glutathione peroxidase 2	GPX2	0.0007
4038	Glutathione peroxidase 4	GPX4	0.0007
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0007
906	Glutathione peroxidase 1	GPX1	0.0007
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0007
4035	Glutathione S-transferase Mu 5	GSTM5	0.0007
4036	Glutathione peroxidase 6	GPX6	0.0007
900	Glutathione S-transferase A4	GSTA4	0.0007
911	Glutathione peroxidase 3	GPX3	0.0007
4042	Glutathione transferase omega-2	GSTO2	0.0007
4033	S-formylglutathione hydrolase	ESD	0.0007
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0007
162	Retinoic acid receptor gamma-1	RARG	0.0007
163	D(1B) dopamine receptor	DRD5	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6151	Monocarboxylate transporter 10	SLC16A10	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0007
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0007
898	Glutathione S-transferase A3	GSTA3	0.0007
897	Glutathione S-transferase kappa 1	GSTK1	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
909	Maleylacetoacetate isomerase	GSTZ1	0.0007
976	Platelet glycoprotein IX	GP9	0.0007
1374	Natriuretic peptides B	NPPB	0.0006
1827	Gap junction alpha-1 protein	GJA1	0.0006
1908	Vascular cell adhesion protein 1	VCAM1	0.0006
899	Glutathione S-transferase Mu 3	GSTM3	0.0006
905	Glutathione transferase omega-1	GSTO1	0.0006
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0006
2216	Fibroblast growth factor receptor 4	FGFR4	0.0006
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0006
4041	Microsomal glutathione S-transferase 2	MGST2	0.0006
4217	Telomerase reverse transcriptase	TERT	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
814	Ryanodine receptor 1	RYR1	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0006
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0006
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0006
2165	Glutathione S-transferase Mu 2	GSTM2	0.0006
174	Sigma 1-type opioid receptor	SIGMAR1	0.0006
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0006
207	Glutathione synthetase	GSS	0.0006
5269	Glutathione synthetase	gshB	0.0006
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
6048	Troponin C, skeletal muscle	TNNC2	0.0006
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0006
901	Glutathione S-transferase Mu 4	GSTM4	0.0005
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0005
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
2021	Thrombomodulin	THBD	0.0005
2207	Rhodopsin	RHO	0.0005
5798	Mitogen-activated protein kinase 11	MAPK11	0.0005
183	Vascular endothelial growth factor A	VEGFA	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0005
2320	Thymidine kinase, cytosolic	TK1	0.0005
4031	Glutathione S-transferase A1	GSTA1	0.0005
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0005
714	Glutathione reductase, mitochondrial	GSR	0.0005
233	Potassium channel subfamily K member 2	KCNK2	0.0005
1864	RET proto-oncogene	RET	0.0005
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0005
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0005
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
1275	Estrogen sulfotransferase	SULT1E1	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
1050	Bile salt sulfotransferase	SULT2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
3221	Cytochrome c4	cc4	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0004
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0004
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0004
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0004
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0004
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0004
6102	Arylamine N-acetyltransferase 2	NAT2	0.0004
5934	Cytochrome P450 26A1	CYP26A1	0.0004
4311	tRNA	TRDMT1	0.0004
4325	tRNA	trmD	0.0004
4328	tRNA	trmD	0.0004
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0004
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0004
2802	Endoglucanase G	celCCG	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0004
6014	Cytochrome P450 2A13	CYP2A13	0.0003
444	Alcohol dehydrogenase 1B	ADH1B	0.0003
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0003
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0003
164	Histamine H4 receptor	HRH4	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01202 - Levetiracetam

Targets

Transporters

Predictions