DT-Web

DB00345 - Aminohippurate


Identification
Name Aminohippurate
Accession Number DB00345 (APRD00792)
Type small molecule
Description The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 194.1873
Groups approved
Monoisotopic Weight 194.069142196
Pharmacology
Indication Used to measure effective renal plasma flow (ERPF) and to determine the functional capacity of the tubular excretory mechanism.
Mechanism of action Aminohippurate is filtered by the renal glomeruli and secreted into the urine by the proximal tubules. By measuring the amount of drug in the urine it is possible to determine functional capacity and effective renal plasma flow.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity The intravenous LD50 in female mice is 7.22 g/kg.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions inhibitor
References
  • Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed
DTHybrid score 0.3554
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Zhang L, Dresser MJ, Chun JK, Babbitt PC, Giacomini KM: Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A). J Biol Chem. 1997 Jun 27;272(26):16548-54. - Pubmed
  • Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed
DTHybrid score 0.4292
Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
  • Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. - Pubmed
DTHybrid score 0.4244
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Ito T, Yano I, Tanaka K, Inui KI: Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther. 1997 Aug;282(2):955-60. - Pubmed
DTHybrid score 0.5245
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions substrate,inhibitor
References
  • Cihlar T, Ho ES: Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem. 2000 Jul 15;283(1):49-55. - Pubmed
  • Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. - Pubmed
  • Ichida K, Hosoyamada M, Kimura H, Takeda M, Utsunomiya Y, Hosoya T, Endou H: Urate transport via human PAH transporter hOAT1 and its gene structure. Kidney Int. 2003 Jan;63(1):143-55. - Pubmed
  • Pombrio JM, Giangreco A, Li L, Wempe MF, Anders MW, Sweet DH, Pritchard JB, Ballatori N: Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1. Mol Pharmacol. 2001 Nov;60(5):1091-9. - Pubmed
  • Tsuda M, Sekine T, Takeda M, Cha SH, Kanai Y, Kimura M, Endou H: Transport of ochratoxin A by renal multispecific organic anion transporter 1. J Pharmacol Exp Ther. 1999 Jun;289(3):1301-5. - Pubmed
  • Islinger F, Gekle M, Wright SH: Interaction of 2,3-dimercapto-1-propane sulfonate with the human organic anion transporter hOAT1. J Pharmacol Exp Ther. 2001 Nov;299(2):741-7. - Pubmed
  • Motojima M, Hosokawa A, Yamato H, Muraki T, Yoshioka T: Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake. Br J Pharmacol. 2002 Jan;135(2):555-63. - Pubmed
  • Groves CE, Munoz L, Bahn A, Burckhardt G, Wright SH: Interaction of cysteine conjugates with human and rabbit organic anion transporter 1. J Pharmacol Exp Ther. 2003 Feb;304(2):560-6. - Pubmed
  • Aslamkhan A, Han YH, Walden R, Sweet DH, Pritchard JB: Stoichiometry of organic anion/dicarboxylate exchange in membrane vesicles from rat renal cortex and hOAT1-expressing cells. Am J Physiol Renal Physiol. 2003 Oct;285(4):F775-83. Epub 2003 Jul 1. - Pubmed
  • Hosoyamada M, Sekine T, Kanai Y, Endou H: Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol. 1999 Jan;276(1 Pt 2):F122-8. - Pubmed
  • Lu R, Chan BS, Schuster VL: Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol. 1999 Feb;276(2 Pt 2):F295-303. - Pubmed
  • Cihlar T, Lin DC, Pritchard JB, Fuller MD, Mendel DB, Sweet DH: The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol. 1999 Sep;56(3):570-80. - Pubmed
  • Ho ES, Lin DC, Mendel DB, Cihlar T: Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. J Am Soc Nephrol. 2000 Mar;11(3):383-93. - Pubmed
  • Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. - Pubmed
  • Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H: Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem. 1997 Jul 25;272(30):18526-9. - Pubmed
  • Sweet DH, Wolff NA, Pritchard JB: Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J Biol Chem. 1997 Nov 28;272(48):30088-95. - Pubmed
  • Uwai Y, Saito H, Hashimoto Y, Inui KI: Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J Pharmacol Exp Ther. 2000 Oct;295(1):261-5. - Pubmed
  • Takeda M, Tojo A, Sekine T, Hosoyamada M, Kanai Y, Endou H: Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity. Kidney Int. 1999 Dec;56(6):2128-36. - Pubmed
  • Sugiyama D, Kusuhara H, Shitara Y, Abe T, Meier PJ, Sekine T, Endou H, Suzuki H, Sugiyama Y: Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther. 2001 Jul;298(1):316-22. - Pubmed
  • Li M, Anderson GD, Phillips BR, Kong W, Shen DD, Wang J: Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. Epub 2006 Jan 24. - Pubmed
DTHybrid score 0.62
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions substrate,inhibitor
References
  • Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. - Pubmed
  • Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4. - Pubmed
  • Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. - Pubmed
  • Mori S, Takanaga H, Ohtsuki S, Deguchi T, Kang YS, Hosoya K, Terasaki T: Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab. 2003 Apr;23(4):432-40. - Pubmed
  • Hasegawa M, Kusuhara H, Sugiyama D, Ito K, Ueda S, Endou H, Sugiyama Y: Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J Pharmacol Exp Ther. 2002 Mar;300(3):746-53. - Pubmed
  • Sugiyama D, Kusuhara H, Shitara Y, Abe T, Meier PJ, Sekine T, Endou H, Suzuki H, Sugiyama Y: Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther. 2001 Jul;298(1):316-22. - Pubmed
  • Nagata Y, Kusuhara H, Endou H, Sugiyama Y: Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol Pharmacol. 2002 May;61(5):982-8. - Pubmed
  • Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
  • Bakhiya A, Bahn A, Burckhardt G, Wolff N: Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Cell Physiol Biochem. 2003;13(5):249-56. - Pubmed
  • Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun. 1999 Feb 16;255(2):508-14. - Pubmed
  • Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam SK: Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem. 2002 Jul 26;277(30):26934-43. Epub 2002 May 13. - Pubmed
  • Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed
DTHybrid score 0.5543
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate,inhibitor
References
  • Dahan A, Sabit H, Amidon GL: The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. AAPS J. 2009 Jun;11(2):205-13. Epub 2009 Mar 25. - Pubmed
  • Leier I, Hummel-Eisenbeiss J, Cui Y, Keppler D: ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 2000 Apr;57(4):1636-42. - Pubmed
DTHybrid score 0.3562
Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions inhibitor
References
  • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
DTHybrid score 0.2895
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions substrate,inhibitor
References
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Enomoto A, Tojo A, Cha SH, Sekine T, Sakthisekaran D, Endou H: Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim Biophys Acta. 2002 Jun 12;1590(1-3):64-75. - Pubmed
  • Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem. 2000 Feb 11;275(6):4507-12. - Pubmed
DTHybrid score 0.3959
Solute carrier organic anion transporter family member 3A1
Name Solute carrier organic anion transporter family member 3A1
Gene Name SLCO3A1
Actions inhibitor
References
  • Adachi H, Suzuki T, Abe M, Asano N, Mizutamari H, Tanemoto M, Nishio T, Onogawa T, Toyohara T, Kasai S, Satoh F, Suzuki M, Tokui T, Unno M, Shimosegawa T, Matsuno S, Ito S, Abe T: Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1188-97. - Pubmed
DTHybrid score 0.2057
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions inhibitor
References
  • Nozawa T, Tamai I, Sai Y, Nezu J, Tsuji A: Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin. J Pharm Pharmacol. 2003 Jul;55(7):1013-20. - Pubmed
DTHybrid score 0.3609
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions substrate
References
  • Leier I, Hummel-Eisenbeiss J, Cui Y, Keppler D: ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 2000 Apr;57(4):1636-42. - Pubmed
DTHybrid score 0.3104
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions substrate
References
  • Kanai N, Lu R, Bao Y, Wolkoff AW, Schuster VL: Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol. 1996 Feb;270(2 Pt 2):F319-25. - Pubmed
DTHybrid score 0.3651
Monocarboxylate transporter 1
Name Monocarboxylate transporter 1
Gene Name SLC16A1
Actions substrate
References
  • Tamai I, Sai Y, Ono A, Kido Y, Yabuuchi H, Takanaga H, Satoh E, Ogihara T, Amano O, Izeki S, Tsuji A: Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J Pharm Pharmacol. 1999 Oct;51(10):1113-21. - Pubmed
DTHybrid score 0.2934
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions substrate
References
  • Sun W, Wu RR, van Poelje PD, Erion MD: Isolation of a family of organic anion transporters from human liver and kidney. Biochem Biophys Res Commun. 2001 May 4;283(2):417-22. - Pubmed
  • Kobayashi Y, Ohshiro N, Shibusawa A, Sasaki T, Tokuyama S, Sekine T, Endou H, Yamamoto T: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14. - Pubmed
  • Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. - Pubmed
DTHybrid score 0.3446

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.3424
4757 Cytochrome P450 2C9 CYP2C9 0.2206
4119 Cytochrome P450 2D6 CYP2D6 0.2166
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.212
587 Serum albumin ALB 0.2086
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.2073
4200 Cytochrome P450 1A2 CYP1A2 0.1914
4924 Cytochrome P450 2C8 CYP2C8 0.1904
4118 Cytochrome P450 3A5 CYP3A5 0.1861
6016 Cytochrome P450 2C19 CYP2C19 0.1769
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1741
2164 Multidrug resistance-associated protein 4 ABCC4 0.1662
6147 Solute carrier family 22 member 3 SLC22A3 0.1424
776 Bile salt export pump ABCB11 0.1401
6107 Cytochrome P450 3A7 CYP3A7 0.14
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.1342
489 Monocarboxylate transporter 2 SLC16A7 0.1254
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.1157
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.1144
6141 Sodium/bile acid cotransporter SLC10A1 0.1053
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.1028
20 Prostaglandin G/H synthase 1 PTGS1 0.1016
6030 Cytochrome P450 2B6 CYP2B6 0.0981
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0959
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.095
290 Prostaglandin G/H synthase 2 PTGS2 0.0908
500 Monocarboxylate transporter 4 SLC16A3 0.0888
6024 Cytochrome P450 1A1 CYP1A1 0.0885
6136 Multidrug resistance-associated protein 5 ABCC5 0.0797
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0743
6148 Multidrug resistance-associated protein 7 ABCC10 0.0735
6013 Cytochrome P450 2E1 CYP2E1 0.0717
817 DNA topoisomerase 2-alpha TOP2A 0.0711
404 DNA gyrase subunit A gyrA 0.0676
6224 DNA gyrase subunit A gyrA 0.0676
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0674
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0663
477 DNA topoisomerase 4 subunit A parC 0.061
886 DNA topoisomerase 4 subunit A parC 0.061
6226 DNA topoisomerase 4 subunit A parC 0.061
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0594
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0588
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0581
6167 Organic solute transporter subunit beta OSTB 0.0553
6166 Organic solute transporter subunit alpha OSTA 0.0552
6137 Multidrug resistance-associated protein 6 ABCC6 0.0549
5718 Cytochrome P450 2A6 CYP2A6 0.0533
527 Prostacyclin receptor PTGIR 0.0514
338 DNA polymerase UL30 0.0507
379 DNA polymerase UL54 0.0507
697 DNA polymerase ORF28 0.0507
2482 DNA polymerase 43 0.0507
4104 DNA polymerase BALF5 0.0507
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0503
6149 Solute carrier family 22 member 10 SLC22A10 0.0495
492 Histamine H1 receptor HRH1 0.0485
1898 Cytochrome P450 1B1 CYP1B1 0.0477
22 30S ribosomal protein S4 rpsD 0.0462
6714 30S ribosomal protein S4 rpsD 0.0462
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.046
136 Estrogen receptor ESR1 0.0441
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0439
672 Prostaglandin F2-alpha receptor PTGFR 0.0437
3587 Gastrotropin FABP6 0.0437
140 30S ribosomal protein S9 rpsI 0.0435
6719 30S ribosomal protein S9 rpsI 0.0435
6725 30S ribosomal protein S9 rpsI 0.0435
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0433
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0431
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0419
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0419
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0418
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0418
731 HIV-1 protease HIV-1 protease 0.041
3947 Xanthine dehydrogenase/oxidase XDH 0.0409
633 Penicillin-binding proteins 1A/1B pbpA 0.0404
6106 Cytochrome P450 2C18 CYP2C18 0.0394
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0388
33 Cystine/glutamate transporter SLC7A11 0.0374
124 Histamine H2 receptor HRH2 0.037
3923 Cholinesterase BCHE 0.0367
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0362
766 Beta-2 adrenergic receptor ADRB2 0.0355
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0353
193 Beta-1 adrenergic receptor ADRB1 0.0345
645 Penicillin-binding protein 1A mrcA 0.034
5805 Penicillin-binding protein 1A ponA 0.034
6185 Penicillin-binding protein 1A mrcA 0.034
6799 Penicillin-binding protein 1A pbpA 0.034
556 Alpha-1A adrenergic receptor ADRA1A 0.0339
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0337
4604 Liver carboxylesterase 1 CES1 0.0333
3811 Cytochrome P450 19A1 CYP19A1 0.0326
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0322
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0316
70 Type-1 angiotensin II receptor AGTR1 0.0314
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0314
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.03
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0299
6020 Aldehyde oxidase AOX1 0.0288
6151 Monocarboxylate transporter 10 SLC16A10 0.0283
244 Angiotensin-converting enzyme ACE 0.0275
543 Penicillin-binding protein 1B mrcB 0.0274
6186 Penicillin-binding protein 1B ponB 0.0274
6822 Penicillin-binding protein 1b pbp1b 0.0274
6844 Penicillin-binding protein 1b pbp1b 0.0274
831 D(2) dopamine receptor DRD2 0.0271
5353 Glutamate decarboxylase alpha gadA 0.027
558 Solute carrier family 12 member 1 SLC12A1 0.0265
723 Cytosolic phospholipase A2 PLA2G4A 0.0265
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.026
824 Sodium-dependent serotonin transporter SLC6A4 0.026
275 Arachidonate 5-lipoxygenase ALOX5 0.0259
378 Alpha-2C adrenergic receptor ADRA2C 0.0258
629 Alpha-2B adrenergic receptor ADRA2B 0.0257
474 Acetylcholinesterase ACHE 0.0255
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0253
756 Sex hormone-binding globulin SHBG 0.0252
318 Alpha-2A adrenergic receptor ADRA2A 0.0249
438 Taste receptor type 1 member 2 TAS1R2 0.0248
6010 Thiamine transporter 1 SLC19A2 0.0248
2929 (S)-2-haloacid dehalogenase dhlB 0.0248
2995 (S)-2-haloacid dehalogenase Not Available 0.0248
2472 Voltage-gated potassium channel kcsA 0.0246
6366 Voltage-gated potassium channel kcsA 0.0246
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0242
24 Thymidylate synthase TMP1 0.0242
359 Thymidylate synthase TYMS 0.0242
2626 Thymidylate synthase thyA 0.0242
2729 Thymidylate synthase thyA 0.0242
5352 Thymidylate synthase THYA 0.0242
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.024
5626 Nucleoside diphosphate kinase B NME2 0.0239
1 Peptidoglycan synthetase ftsI ftsI 0.0237
4155 Peptidoglycan synthetase ftsI ftsI 0.0237
3941 Amine oxidase [flavin-containing] A MAOA 0.0236
1757 Myeloperoxidase MPO 0.0235
449 Ornithine decarboxylase ODC1 0.0233
502 5-hydroxytryptamine 2A receptor HTR2A 0.0232
904 Glutathione S-transferase P GSTP1 0.0231
4773 Deoxycytidine kinase DCK 0.0231
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0225
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0224
380 Cytochrome P450 17A1 CYP17A1 0.0224
175 Thiamin pyrophosphokinase 1 TPK1 0.0222
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
632 Alpha-1B adrenergic receptor ADRA1B 0.0221
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0221
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.022
871 Glucocorticoid receptor NR3C1 0.0219
332 Beta-lactamase blaZ 0.0219
2478 Beta-lactamase ampC 0.0219
2613 Beta-lactamase ampC 0.0219
2635 Beta-lactamase ampC 0.0219
2700 Beta-lactamase penP 0.0219
5445 Beta-lactamase blaB 0.0219
6019 Beta-lactamase SHV-7 0.0219
6701 Beta-lactamase cphA 0.0219
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0218
1792 Tissue-type plasminogen activator PLAT 0.0217
5818 Folate receptor alpha FOLR1 0.0215
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0215
373 Transthyretin TTR 0.0213
341 5-hydroxytryptamine 3 receptor HTR3A 0.0211
3560 Gentamicin 3'-acetyltransferase aacC1 0.021
3917 Methylenetetrahydrofolate reductase MTHFR 0.0208
1867 Major prion protein PRNP 0.0208
737 Mineralocorticoid receptor NR3C2 0.0206
2429 Putrescine-binding periplasmic protein potF 0.0206
293 Gamma-glutamyl hydrolase GGH 0.0206
1650 Heme carrier protein 1 SLC46A1 0.0206
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0205
357 Carbonic anhydrase 2 CA2 0.0203
320 5-hydroxytryptamine 1A receptor HTR1A 0.0202
887 DNA gyrase subunit B gyrB 0.0201
4150 DNA gyrase subunit B gyrB 0.0201
6225 DNA gyrase subunit B gyrB 0.0201
624 Guanidinoacetate N-methyltransferase GAMT 0.0201
758 Thyroid hormone receptor alpha THRA 0.0201
789 Alpha-1D adrenergic receptor ADRA1D 0.0199
869 Estrogen receptor beta ESR2 0.0199
7 Nitric oxide synthase, inducible NOS2 0.0199
6218 Pannexin-1 PANX1 0.0198
23 D(1A) dopamine receptor DRD1 0.0198
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0198
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0197
2016 Dipeptidase 1 DPEP1 0.0197
6031 Cytochrome P450 3A43 CYP3A43 0.0196
5294 Nucleoside diphosphate kinase A NME1 0.0194
146 Androgen receptor AR 0.0194
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0192
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.019
5126 Arginase rocF 0.0189
6033 High affinity interleukin-8 receptor A CXCR1 0.0188
6085 Fatty acid-binding protein, intestinal FABP2 0.0188
6599 HTH-type transcriptional regulator ttgR ttgR 0.0188
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0183
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0182
6207 30S ribosomal protein S14 rpsN 0.0179
6209 30S ribosomal protein S19 rpsS 0.0179
6712 30S ribosomal protein S19 rpsS 0.0179
6726 30S ribosomal protein S19 rpsS 0.0179
346 Thyroid hormone receptor beta-1 THRB 0.0179
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0177
2508 Cyclomaltodextrin glucanotransferase cgt 0.0177
2523 Cyclomaltodextrin glucanotransferase cgt 0.0177
3207 Cyclomaltodextrin glucanotransferase amyA 0.0177
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0175
594 Thyroxine-binding globulin SERPINA7 0.0174
131 Synaptic vesicular amine transporter SLC18A2 0.0174
150 Cationic amino acid transporter 3 SLC7A3 0.0173
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0173
58 Cationic amino acid transporter 4 SLC7A4 0.0173
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0173
29 Tubulin beta-1 chain TUBB1 0.0173
273 Apoptosis regulator Bcl-2 BCL2 0.0172
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.017
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.017
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0169
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0169
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0169
3939 Amine oxidase [flavin-containing] B MAOB 0.0168
161 Tubulin beta chain TUBB 0.0168
312 Tubulin beta chain TUB2 0.0168
614 Progesterone receptor PGR 0.0167
2249 Aspartate aminotransferase aspC 0.0167
2671 Aspartate aminotransferase aspC 0.0167
5490 Aspartate aminotransferase Not Available 0.0167
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0165
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0164
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0164
468 Cytochrome P450 4A11 CYP4A11 0.016
3184 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0159
3315 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0159
3179 2-isopropylmalate synthase leuA 0.0159
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0159
713 Sodium-dependent dopamine transporter SLC6A3 0.0159
592 Carbonic anhydrase 4 CA4 0.0159
3810 Catechol O-methyltransferase COMT 0.0158
860 Nicotinamide N-methyltransferase NNMT 0.0157
928 Nicotinic acid receptor 2 GPR109B 0.0157
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0157
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0157
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0157
699 Nicotinic acid receptor 1 GPR109A 0.0157
53 Solute carrier family 12 member 5 SLC12A5 0.0156
663 Solute carrier family 12 member 4 SLC12A4 0.0156
13 Aminomethyltransferase, mitochondrial AMT 0.0154
4238 50S ribosomal protein L4 rplD 0.0153
5578 50S ribosomal protein L4 rplD 0.0153
6173 50S ribosomal protein L4 rplD 0.0153
6219 50S ribosomal protein L4 rplD 0.0153
295 Carbonic anhydrase 1 CA1 0.0153
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0152
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0152
6168 Solute carrier family 22 member 16 SLC22A16 0.0151
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.015
183 Vascular endothelial growth factor A VEGFA 0.015
2320 Thymidine kinase, cytosolic TK1 0.0149
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
6014 Cytochrome P450 2A13 CYP2A13 0.0149
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0147
310 Solute carrier family 12 member 2 SLC12A2 0.0145
976 Platelet glycoprotein IX GP9 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
5650 NimA-related protein DR_0842 0.0142
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0141
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0141
303 Diamine acetyltransferase 2 SAT2 0.0141
1317 Spermine synthase SMS 0.0141
623 Spermine oxidase SMOX 0.0141
4237 50S ribosomal protein L22 rplV 0.0141
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.014
867 Penicillin-binding protein 3 pbpC 0.014
6119 Penicillin-binding protein 3 pbp3 0.014
7154 Penicillin-binding protein 3 pbp3 0.014
7157 Penicillin-binding protein 3 LMHCC_2184 0.014
7162 Penicillin-binding protein 3 pbpB 0.014
7172 Penicillin-binding protein 3 pbp3 0.014
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0139
4132 Chloride channel protein ClC-Ka CLCNKA 0.0139
6500 Phospholipase A2 PLA2G1B 0.0138
4122 Histone deacetylase 2 HDAC2 0.0138
952 Dipeptidyl peptidase 4 DPP4 0.0138
1654 Interleukin-1 beta IL1B 0.0137
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0137
908 Glutathione S-transferase theta-1 GSTT1 0.0135
751 Potassium channel subfamily K member 6 KCNK6 0.0134
199 Monocarboxylate transporter 8 SLC16A2 0.0134
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0134
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0133
4217 Telomerase reverse transcriptase TERT 0.0131
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0131
3307 Acriflavine resistance protein B acrB 0.013
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.013
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0129
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0128
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0128
3685 Catabolite gene activator crp 0.0127
4655 Adenylate cyclase cyaC 0.0127
4759 Adenylate cyclase cyaB2 0.0127
3334 Deacetoxycephalosporin C synthetase cefE 0.0127
885 5-hydroxytryptamine 1B receptor HTR1B 0.0127
123 Diamine acetyltransferase 1 SAT1 0.0127
3639 Thymidine phosphorylase deoA 0.0127
3936 Thymidine phosphorylase TYMP 0.0127
1852 Microtubule-associated protein 2 MAP2 0.0126
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0125
365 Dihydrofolate reductase DHFR 0.0125
2381 Dihydrofolate reductase DFR1 0.0125
2833 Dihydrofolate reductase Not Available 0.0125
2931 Dihydrofolate reductase folA 0.0125
3544 Dihydrofolate reductase folA 0.0125
3682 Dihydrofolate reductase folA 0.0125
6642 Dihydrofolate reductase folA 0.0125
6756 Dihydrofolate reductase dfrA 0.0125
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0124
130 Prostacyclin synthase PTGIS 0.0124
172 Potassium channel subfamily K member 1 KCNK1 0.0123
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
65 Matrix metalloproteinase-9 Not Available 0.0122
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0121
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0121
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0121
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.012
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.012
2300 Lysozyme E 0.012
3633 Lysozyme R 0.012
5597 Lysozyme 17 0.012
5923 Microtubule-associated protein tau MAPT 0.0119
5924 Microtubule-associated protein 4 MAP4 0.0119
551 Carnitine O-acetyltransferase CRAT 0.0119
4203 Histamine N-methyltransferase HNMT 0.0119
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
1517 Beta-3 adrenergic receptor ADRB3 0.0119
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0117
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0117
6043 Putative G-protein coupled receptor 44 GPR44 0.0116
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0116
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0116
2981 Phospholipase A2, membrane associated PLA2G2A 0.0115
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0115
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0115
26 Vascular endothelial growth factor receptor 3 FLT4 0.0114
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0114
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0113
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0113
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0113
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0113
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0113
3426 Glutamine synthetase glnA 0.0113
3987 Glutamine synthetase GLUL 0.0113
725 5-hydroxytryptamine 1D receptor HTR1D 0.0113
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0113
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0112
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0112
221 Lysyl-tRNA synthetase KARS 0.0112
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
494 Caspase-1 CASP1 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
32 Vascular endothelial growth factor receptor 1 FLT1 0.011
6837 Serine/threonine-protein kinase 17B STK17B 0.0109
465 Calmodulin CALM1 0.0109
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0109
4760 Mll3241 protein mll3241 0.0109
2443 Azurin azu 0.0108
5682 Ribonuclease pancreatic RNASE1 0.0108
828 Phenylalanine-4-hydroxylase PAH 0.0107
3109 Phenylalanine-4-hydroxylase phhA 0.0107
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0107
4120 NADPH--cytochrome P450 reductase POR 0.0106
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0106
6432 Transporter snf 0.0105
1507 Cytochrome c CYCS 0.0105
6171 Solute carrier family 28 member 3 SLC28A3 0.0105
1629 Transcription factor AP-1 JUN 0.0104
6042 Prostaglandin reductase 2 PTGR2 0.0104
6126 Carbonic anhydrase 7 CA7 0.0103
1198 Serum paraoxonase/arylesterase 1 PON1 0.0102
844 Epidermal growth factor receptor EGFR 0.0102
6223 Penicillin-binding protein 1C pbpC 0.0102
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0102
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0102
702 UMP-CMP kinase CMPK1 0.0101
504 Mast/stem cell growth factor receptor KIT 0.0101
1353 DNA topoisomerase 1 TOP1 0.01
3552 DNA topoisomerase 1 topA 0.01
3760 Penicillin-binding protein 5 precursor dacA 0.01
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
2021 Thrombomodulin THBD 0.0099
1039 Histone deacetylase 9 HDAC9 0.0098
6165 Copper-transporting ATPase 1 ATP7A 0.0098
6163 Copper-transporting ATPase 2 ATP7B 0.0098
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0098
694 Matrix protein 2 M 0.0098
2449 Tubulin alpha-3 chain TUBA1A 0.0097
2539 Tubulin alpha-1 chain TUBA4A 0.0097
1405 Thiopurine S-methyltransferase TPMT 0.0097
228 Beta platelet-derived growth factor receptor PDGFRB 0.0096
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
185 Vasopressin V1a receptor AVPR1A 0.0096
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0095
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0095
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
6210 Tubulin delta chain TUBD1 0.0095
6212 Tubulin gamma-1 chain TUBG1 0.0095
6211 Tubulin epsilon chain TUBE1 0.0095
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0094
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0094
1341 Histamine H3 receptor HRH3 0.0094
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0094
6146 High affinity copper uptake protein 1 SLC31A1 0.0094
2599 Tyrosine-protein kinase HCK HCK 0.0094
322 Vasopressin V2 receptor AVPR2 0.0093
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
2077 Caspase-3 CASP3 0.0093
1178 Adenosine A2a receptor ADORA2A 0.0093
4192 DNA topoisomerase 2-beta TOP2B 0.0093
461 Glycine receptor subunit alpha-3 GLRA3 0.0093
164 Histamine H4 receptor HRH4 0.0093
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0093
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0092
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
407 Vascular endothelial growth factor receptor 2 KDR 0.0092
1313 Lactoylglutathione lyase GLO1 0.0092
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0092
638 D(3) dopamine receptor DRD3 0.0091
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0091
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0091
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0091
769 High-affinity choline transporter 1 SLC5A7 0.0091
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0091
3926 Choline transporter-like protein 2 SLC44A2 0.0091
1686 Choline transporter-like protein 1 SLC44A1 0.0091
861 Choline kinase alpha CHKA 0.0091
3927 Choline transporter-like protein 3 SLC44A3 0.0091
700 Choline dehydrogenase, mitochondrial CHDH 0.0091
3925 Choline transporter-like protein 4 SLC44A4 0.0091
576 Choline O-acetyltransferase CHAT 0.0091
3922 Phospholipase D2 PLD2 0.0091
3924 Phospholipase D1 PLD1 0.0091
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
896 Glutathione S-transferase Mu 1 GSTM1 0.009
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.009
819 Penicillin-binding protein 4 dacB 0.009
499 Arginine decarboxylase ADC 0.0089
6070 Nischarin NISCH 0.0089
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0089
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0087
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0087
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0087
740 Argininosuccinate synthase ASS1 0.0086
865 Argininosuccinate synthase ASS1 0.0086
2680 Argininosuccinate synthase argG 0.0086
3194 Argininosuccinate synthase argG 0.0086
3014 Ribonuclease UK114 HRSP12 0.0086
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0086
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0086
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0086
5428 Replication protein repA 0.0086
3617 Non-heme chloroperoxidase cpo 0.0086
5426 Non-heme chloroperoxidase cpo 0.0086
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0086
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0086
3018 HTH-type transcriptional regulator malT malT 0.0086
577 Argininosuccinate lyase ASL 0.0085
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0085
2391 Ferrochelatase hemH 0.0085
6502 Ferrochelatase DKFZp686P18130 0.0085
1591 Ferrochelatase, mitochondrial FECH 0.0085
16 Adenosine A1 receptor ADORA1 0.0085
834 Arginase-2, mitochondrial ARG2 0.0084
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0084
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0084
847 Mu-type opioid receptor OPRM1 0.0084
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0083
511 5-hydroxytryptamine 1F receptor HTR1F 0.0082
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0082
277 Purine nucleoside phosphorylase PNP 0.0082
2870 Purine nucleoside phosphorylase punA 0.0082
2945 Purine nucleoside phosphorylase punA 0.0082
4659 Purine nucleoside phosphorylase TM_1596 0.0082
4825 Purine nucleoside phosphorylase TTHA1435 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
467 Delta-type opioid receptor OPRD1 0.0081
5880 Thrombopoietin receptor MPL 0.0081
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.008
818 50S ribosomal protein L10 rplJ 0.0079
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0079
2808 Chloramphenicol acetyltransferase 3 cat3 0.0079
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0079
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0079
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0079
696 Kappa-type opioid receptor OPRK1 0.0077
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0077
1830 5'-nucleotidase NT5E 0.0077
1192 Sulfotransferase 1A1 SULT1A1 0.0076
3809 Estrogen-related receptor gamma ESRRG 0.0076
1360 Sphingomyelin phosphodiesterase SMPD1 0.0076
1630 Integrin beta-2 ITGB2 0.0075
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0075
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0075
3611 Cytidine deaminase cdd 0.0074
3707 Cytidine deaminase cdd 0.0074
4211 Cytidine deaminase CDA 0.0074
125 DNA polymerase beta POLB 0.0074
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0074
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0074
432 D(4) dopamine receptor DRD4 0.0074
2958 Probable tautomerase ydcE pptA 0.0074
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0074
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0074
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0074
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0074
2573 Cocaine esterase cocE 0.0074
7263 Cocaine esterase Not Available 0.0074
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0074
6493 Cytochrome c oxidase subunit 6C COX6C 0.0074
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0074
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0074
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0074
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0073
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0073
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0073
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0073
6559 Cytochrome c oxidase subunit 2 ctaC 0.0073
6669 Cytochrome c oxidase subunit 2 ctaC 0.0073
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0073
6558 Cytochrome c oxidase subunit 1 ctaD 0.0073
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0073
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0073
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0073
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0073
163 D(1B) dopamine receptor DRD5 0.0073
3115 Ras-related protein Rab-9 RAB9A 0.0073
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0072
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0072
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
291 Nitric-oxide synthase, endothelial NOS3 0.0071
1074 Urokinase-type plasminogen activator PLAU 0.0071
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.007
1770 Phospholipase C PLCL1 0.007
2841 Phospholipase C plc 0.007
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0069
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0068
436 5-hydroxytryptamine 2B receptor HTR2B 0.0068
284 DNA-directed RNA polymerase beta chain rpoB 0.0067
5773 DNA-directed RNA polymerase beta chain rpoB 0.0067
2540 Choloylglycine hydrolase cbh 0.0067
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0067
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0067
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0067
260 Cytochrome P450 51 ERG11 0.0066
761 Cytochrome P450 51 ERG11 0.0066
3163 Cytochrome P450 51 cyp51 0.0066
1760 Aminopeptidase N ANPEP 0.0066
6843 Aminopeptidase N pepN 0.0066
6138 Multidrug resistance protein 3 ABCB4 0.0065
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0064
117 Sterol O-acyltransferase 1 SOAT1 0.0064
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0064
6501 Fatty acid-binding protein, liver FABP1 0.0063
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
469 Annexin A1 ANXA1 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
3270 Elongation factor G fusA 0.0062
6131 Carbonic anhydrase 14 CA14 0.0062
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0062
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0062
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0062
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0062
6044 Serum paraoxonase/lactonase 3 PON3 0.0061
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0061
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.006
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
198 Sodium channel protein type 10 subunit alpha SCN10A 0.006
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
397 Monocarboxylate transporter 3 SLC16A8 0.0059
195 Monocarboxylate transporter 7 SLC16A6 0.0058
218 Monocarboxylate transporter 5 SLC16A4 0.0058
429 Monocarboxylate transporter 6 SLC16A5 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
6111 DNA polymerase epsilon subunit 4 POLE4 0.0058
6112 DNA polymerase epsilon subunit 3 POLE3 0.0058
6122 Carbonic anhydrase 3 CA3 0.0058
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0058
6110 DNA polymerase epsilon subunit 2 POLE2 0.0058
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0058
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0058
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0057
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
6220 Aryl hydrocarbon receptor AHR 0.0057
788 Creatine kinase M-type CKM 0.0057
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0057
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0056
572 Integrin alpha-L ITGAL 0.0056
2693 Heat-labile enterotoxin B chain eltB 0.0056
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0056
777 Tumor necrosis factor TNF 0.0056
1050 Bile salt sulfotransferase SULT2A1 0.0055
3007 Carbonic anhydrase 12 CA12 0.0055
4205 Carbonic anhydrase 9 CA9 0.0055
590 5-hydroxytryptamine 2C receptor HTR2C 0.0055
6645 D-amino-acid oxidase DAO 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
3932 Glutathione S-transferase A2 GSTA2 0.0054
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0054
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0054
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0053
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0053
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0053
6182 Cytochrome P450 2J2 CYP2J2 0.0052
52 Pyruvate kinase isozymes R/L PKLR 0.0052
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0052
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
232 Corticosteroid-binding globulin SERPINA6 0.005
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.005
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.005
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.005
153 Dopamine beta-hydroxylase DBH 0.0049
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
771 Pyruvate carboxylase, mitochondrial PC 0.0049
1714 Mitogen-activated protein kinase 3 MAPK3 0.0049
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0048
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0048
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0047
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0047
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0047
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
517 Alcohol dehydrogenase 1C ADH1C 0.0047
768 FK506-binding protein 1A FKBP1A 0.0046
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0046
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0046
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0045
5787 Angiopoietin-1 receptor TEK 0.0045
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0045
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0045
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0044
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0044
165 FL cytokine receptor FLT3 0.0044
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0044
603 DNA polymerase alpha catalytic subunit POLA1 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
992 Protein tyrosine kinase 2 beta PTK2B 0.0042
1525 Heparin-binding growth factor 2 FGF2 0.0042
1291 cAMP response element-binding protein CREB1 0.0041
408 Riboflavin kinase RFK 0.0041
4210 Toll-like receptor 4 TLR4 0.0041
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.004
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0039
5482 Sialidase-2 NEU2 0.0039
2408 Tyrosine-protein kinase SYK SYK 0.0039
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0039
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0039
563 Thyroid peroxidase TPO 0.0038
1864 RET proto-oncogene RET 0.0038
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0038
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0038
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0038
1618 High affinity nerve growth factor receptor NTRK1 0.0038
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0037
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0037
3856 Fibroblast growth factor receptor 3 FGFR3 0.0037
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0037
122 P2Y purinoceptor 12 P2RY12 0.0036
707 72 kDa type IV collagenase MMP2 0.0036
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0036
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0036
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0036
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0036
1569 G1/S-specific cyclin-D1 CCND1 0.0036
997 Protein kinase C beta type PRKCB 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0034
4226 Uridine phosphorylase 2 UPP2 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
634 Squalene monooxygenase SQLE 0.0033
7196 Squalene monooxygenase ERG1 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0031
6228 Nuclear receptor coactivator 1 NCOA1 0.003
4225 Uridine phosphorylase 1 UPP1 0.003
6241 Nuclear receptor coactivator 2 NCOA2 0.003
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0029
654 Flavin reductase BLVRB 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0029
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0029
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0029
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0029
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0029
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0029
413 Amidophosphoribosyltransferase PPAT 0.0029
2515 Amidophosphoribosyltransferase purF 0.0029
3714 Amidophosphoribosyltransferase purF 0.0029
683 Potassium transporter GK0582 0.0029
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0029
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0029
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0029
84 Nuclear receptor 0B1 NR0B1 0.0029
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
3957 Adenosine deaminase ADA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
1010 Cytochrome P450 51A1 CYP51A1 0.0028
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0027
1025 Aquaporin-1 AQP1 0.0027
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0027
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0027
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0026
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0025
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
1176 Mitogen-activated protein kinase 1 MAPK1 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0023
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0023
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0023
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0022
3830 Calreticulin CALR 0.0022
760 Fibroblast growth factor 1 FGF1 0.0022
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0022
716 5-hydroxytryptamine 7 receptor HTR7 0.0021
921 Glutamate receptor 2 GRIA2 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
1656 CYP2B protein CYP2B 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
5934 Cytochrome P450 26A1 CYP26A1 0.0019
76 Nitric-oxide synthase, brain NOS1 0.0019
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
267 Plasminogen activator inhibitor 1 SERPINE1 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0017
1928 Leukotriene C4 synthase LTC4S 0.0017
4034 Glutaredoxin-1 GLRX 0.0017
910 Epididymal secretory glutathione peroxidase GPX5 0.0017
4037 Hypothetical protein GPX1 0.0017
4297 Hypothetical protein SP_1951 0.0017
4521 Hypothetical protein BC_2969 0.0017
4540 Hypothetical protein TM_1070 0.0017
4555 Hypothetical protein MT1739 0.0017
4569 Hypothetical protein mshD 0.0017
4578 Hypothetical protein PA3270 0.0017
4747 Hypothetical protein PA3967 0.0017
5177 Hypothetical protein TM_0096 0.0017
5194 Hypothetical protein PA1204 0.0017
5240 Hypothetical protein Rv2991 0.0017
5370 Hypothetical protein TM_1158 0.0017
5710 Hypothetical protein Tb927.5.1360 0.0017
4029 Microsomal glutathione S-transferase 3 MGST3 0.0017
4036 Glutathione peroxidase 6 GPX6 0.0017
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0017
4032 Microsomal glutathione S-transferase 1 MGST1 0.0017
903 Glutathione S-transferase A5 GSTA5 0.0017
4040 Glutathione peroxidase 7 GPX7 0.0017
907 Glutathione peroxidase 2 GPX2 0.0017
900 Glutathione S-transferase A4 GSTA4 0.0017
911 Glutathione peroxidase 3 GPX3 0.0017
906 Glutathione peroxidase 1 GPX1 0.0017
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0017
4035 Glutathione S-transferase Mu 5 GSTM5 0.0017
4042 Glutathione transferase omega-2 GSTO2 0.0017
4038 Glutathione peroxidase 4 GPX4 0.0017
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0017
4033 S-formylglutathione hydrolase ESD 0.0017
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
6824 Tyrosine-protein kinase Lyn LYN 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
484 Tyrosine-protein kinase ABL2 ABL2 0.0016
6221 Steroid hormone receptor ERR1 ESRRA 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
3319 Hydroxyacylglutathione hydrolase HAGH 0.0016
898 Glutathione S-transferase A3 GSTA3 0.0016
897 Glutathione S-transferase kappa 1 GSTK1 0.0015
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
6755 Poliovirus receptor PVR 0.0015
909 Maleylacetoacetate isomerase GSTZ1 0.0015
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0015
899 Glutathione S-transferase Mu 3 GSTM3 0.0015
905 Glutathione transferase omega-1 GSTO1 0.0015
340 Apoptotic protease-activating factor 1 APAF1 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
1275 Estrogen sulfotransferase SULT1E1 0.0015
4041 Microsomal glutathione S-transferase 2 MGST2 0.0015
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
2165 Glutathione S-transferase Mu 2 GSTM2 0.0014
6102 Arylamine N-acetyltransferase 2 NAT2 0.0014
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0014
822 Aldose reductase AKR1B1 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
207 Glutathione synthetase GSS 0.0013
5269 Glutathione synthetase gshB 0.0013
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0013
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0013
1912 Excitatory amino acid transporter 1 SLC1A3 0.0013
4019 Excitatory amino acid transporter 4 SLC1A6 0.0013
922 Glutamate receptor 4 GRIA4 0.0013
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0013
4026 Aspartyl aminopeptidase DNPEP 0.0013
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0013
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0013
4016 Excitatory amino acid transporter 5 SLC1A7 0.0013
1047 Excitatory amino acid transporter 2 SLC1A2 0.0013
927 Metabotropic glutamate receptor 8 GRM8 0.0013
664 Glutamate decarboxylase 2 GAD2 0.0013
3890 Glutamate decarboxylase 2 GAD2 0.0013
4020 Glutamyl aminopeptidase ENPEP 0.0013
4018 Glutamate receptor delta-2 subunit GRID2 0.0013
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0013
925 Metabotropic glutamate receptor 4 GRM4 0.0013
926 Metabotropic glutamate receptor 7 GRM7 0.0013
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0013
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0013
4027 Glutamate receptor delta-1 subunit GRID1 0.0013
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0013
4017 5-oxoprolinase OPLAH 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
901 Glutathione S-transferase Mu 4 GSTM4 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
625 Glutamate carboxypeptidase 2 FOLH1 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
292 Activin receptor type-1 ACVR1 0.0012
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6859 Protein S100-A4 S100A4 0.0012
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0012
4031 Glutathione S-transferase A1 GSTA1 0.0012
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0011
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0011
5 Glutaminase liver isoform, mitochondrial GLS2 0.0011
917 Glutaminase kidney isoform, mitochondrial GLS 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0011
5261 Phosphoribosylformylglycinamidine synthase purL 0.0011
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
714 Glutathione reductase, mitochondrial GSR 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
916 Metabotropic glutamate receptor 1 GRM1 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
665 Phosphoserine aminotransferase PSAT1 0.0011
4652 Phosphoserine aminotransferase serC 0.0011
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0011
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0011
420 Glutamate decarboxylase 1 GAD1 0.0011
3900 Glutamate decarboxylase 1 GAD1 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0011
6459 Glycodelin PAEP 0.0011
923 Glutamate receptor 3 GRIA3 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
427 Substance-P receptor TACR1 0.0011
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0011
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0011
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
1671 Excitatory amino acid transporter 3 SLC1A1 0.001
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.001
144 Hemoglobin subunit alpha HBA1 0.001
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.001
3877 Growth-inhibiting protein 18 GIG18 0.001
426 Aspartate aminotransferase, mitochondrial GOT2 0.001
106 Cannabinoid receptor 2 CNR2 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
811 Translocator protein TSPO 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
763 Tyrosine aminotransferase TAT 0.001
5493 Tyrosine aminotransferase Not Available 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
735 Alanine aminotransferase 1 GPT 0.001
3904 Alanine aminotransferase 2 GPT2 0.001
586 Aspartate aminotransferase, cytoplasmic GOT1 0.001
68 Cannabinoid receptor 1 CNR1 0.001
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
661 ADP/ATP translocase 1 SLC25A4 0.0009
6021 Adenosine kinase ADK 0.0009
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0009
936 Ephrin type-A receptor 2 EPHA2 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0009
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
705 Glutamate receptor 1 GRIA1 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
54 Prothrombin F2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
823 Fibroblast growth factor receptor 2 FGFR2 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
229 Retinoic acid receptor beta RARB 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
1256 5-hydroxytryptamine 6 receptor HTR6 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6677 Myelin P2 protein PMP2 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
2207 Rhodopsin RHO 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0003
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