DT-Web

DB00067 - Vasopressin


Identification
Name Vasopressin
Accession Number DB00067 (BIOD00110, BTD00110)
Type biotech
Description Antidiuretic hormone, also known as vasopressin, is a nine amino acid peptide secreted from the posterior pituitary. Antidiuretic hormone binds to receptors in the distal or collecting tubules of the kidney and promotes reabsorbtion of water back into the circulation
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 1050.2150
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding
Mechanism of action Vasopressin acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of vasopressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
Absorption Not Available
Protein binding 1%
Biotransformation The majority of a dose of vasopressin is metabolized and rapidly destroyed in the liver and kidneys.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Vasopressin V2 receptor
Name Vasopressin V2 receptor
Gene Name AVPR2
Pharmacological action yes
Actions agonist
References
  • Boson WL, Della Manna T, Damiani D, Miranda DM, Gadelha MR, Liberman B, Correa H, Romano-Silva MA, Friedman E, Silva FF, Ribeiro PA, De Marco L: Novel vasopressin type 2 (AVPR2) gene mutations in Brazilian nephrogenic diabetes insipidus patients. Genet Test. 2006 Fall;10(3):157-62. - Pubmed
  • Slusarz MJ, Slusarz R, Ciarkowski J: Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system. Biopolymers. 2006 Apr 5;81(5):321-38. - Pubmed
  • Bouley R, Hawthorn G, Russo LM, Lin HY, Ausiello DA, Brown D: Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment. Biol Cell. 2006 Apr;98(4):215-32. - Pubmed
  • Yi X, Bouley R, Lin HY, Bechoua S, Sun TX, Del Re E, Shioda T, Raychowdhury MK, Lu HA, Abou-Samra AB, Brown D, Ausiello DA: Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R. Am J Physiol Renal Physiol. 2007 May;292(5):F1303-13. Epub 2007 Feb 6. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.2354
Vasopressin V1a receptor
Name Vasopressin V1a receptor
Gene Name AVPR1A
Pharmacological action yes
Actions Not Available
References
  • Hiroyama M, Wang S, Aoyagi T, Oikawa R, Sanbe A, Takeo S, Tanoue A: Vasopressin promotes cardiomyocyte hypertrophy via the vasopressin V1A receptor in neonatal mice. Eur J Pharmacol. 2007 Mar 22;559(2-3):89-97. Epub 2006 Dec 29. - Pubmed
  • Liedman R, Grant L, Igidbashian S, James I, McLeod A, Skillern L, Akerlund M: Intrauterine pressure, ischemia markers, and experienced pain during administration of a vasopressin V1a receptor antagonist in spontaneous and vasopressin-induced dysmenorrhea. Acta Obstet Gynecol Scand. 2006;85(2):207-11. - Pubmed
  • Adikesavan NV, Mahmood SS, Stanley N, Xu Z, Wu N, Thibonnier M, Shoham M: A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Apr 1;61(Pt 4):341-5. Epub 2005 Mar 24. - Pubmed
  • Hammock EA, Lim MM, Nair HP, Young LJ: Association of vasopressin 1a receptor levels with a regulatory microsatellite and behavior. Genes Brain Behav. 2005 Jul;4(5):289-301. - Pubmed
  • Aoyagi T, Birumachi J, Hiroyama M, Fujiwara Y, Sanbe A, Yamauchi J, Tanoue A: Alteration of glucose homeostasis in V1a vasopressin receptor-deficient mice. Endocrinology. 2007 May;148(5):2075-84. Epub 2007 Feb 15. - Pubmed
DTHybrid score 1.5136
Vasopressin V1b receptor
Name Vasopressin V1b receptor
Gene Name AVPR1B
Pharmacological action yes
Actions Not Available
References
  • Young WS, Li J, Wersinger SR, Palkovits M: The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy. Neuroscience. 2006 Dec 28;143(4):1031-9. Epub 2006 Oct 4. - Pubmed
  • Volpi S, Liu Y, Aguilera G: Vasopressin increases GAGA binding activity to the V1b receptor promoter through transactivation of the MAP kinase pathway. J Mol Endocrinol. 2006 Jun;36(3):581-90. - Pubmed
  • Wersinger SR, Caldwell HK, Christiansen M, Young WS 3rd: Disruption of the vasopressin 1b receptor gene impairs the attack component of aggressive behavior in mice. Genes Brain Behav. 2007 Oct;6(7):653-60. Epub 2006 Dec 20. - Pubmed
  • Slusarz MJ, Gieldon A, Slusarz R, Ciarkowski J: Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors-molecular dynamics study of the activated receptor-vasopressin-G(alpha) systems. J Pept Sci. 2006 Mar;12(3):180-9. - Pubmed
  • Jurkevich A, Berghman LR, Cornett LE, Kuenzel WJ: Characterization and immunohistochemical visualization of the vasotocin VT2 receptor in the pituitary gland of the chicken, Gallus gallus. Gen Comp Endocrinol. 2005 Aug;143(1):82-91. Epub 2005 Mar 23. - Pubmed
DTHybrid score 1.033

Transporters


Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate
References
  • Madon J, Hagenbuch B, Landmann L, Meier PJ, Stieger B: Transport function and hepatocellular localization of mrp6 in rat liver. Mol Pharmacol. 2000 Mar;57(3):634-41. - Pubmed
DTHybrid score 0.2696

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1342
290 Prostaglandin G/H synthase 2 PTGS2 0.1068
20 Prostaglandin G/H synthase 1 PTGS1 0.1024
1588 Multidrug resistance protein 1 ABCB1 0.0952
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0277
862 Multidrug resistance-associated protein 1 ABCC1 0.0271
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0268
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.025
776 Bile salt export pump ABCB11 0.0224
2164 Multidrug resistance-associated protein 4 ABCC4 0.0205
4757 Cytochrome P450 2C9 CYP2C9 0.0205
4118 Cytochrome P450 3A5 CYP3A5 0.0204
4924 Cytochrome P450 2C8 CYP2C8 0.0197
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0178
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0169
6107 Cytochrome P450 3A7 CYP3A7 0.0168
70 Type-1 angiotensin II receptor AGTR1 0.0158
13 Aminomethyltransferase, mitochondrial AMT 0.0154
6016 Cytochrome P450 2C19 CYP2C19 0.0138
4200 Cytochrome P450 1A2 CYP1A2 0.0135
6030 Cytochrome P450 2B6 CYP2B6 0.0127
118 Organic cation/carnitine transporter 2 SLC22A5 0.0124
6148 Multidrug resistance-associated protein 7 ABCC10 0.0119
1729 Solute carrier family 22 member 6 SLC22A6 0.0118
477 DNA topoisomerase 4 subunit A parC 0.0113
886 DNA topoisomerase 4 subunit A parC 0.0113
6226 DNA topoisomerase 4 subunit A parC 0.0113
404 DNA gyrase subunit A gyrA 0.0111
6224 DNA gyrase subunit A gyrA 0.0111
817 DNA topoisomerase 2-alpha TOP2A 0.0109
6141 Sodium/bile acid cotransporter SLC10A1 0.0109
2443 Azurin azu 0.0108
6144 Solute carrier family 22 member 2 SLC22A2 0.0102
4119 Cytochrome P450 2D6 CYP2D6 0.01
587 Serum albumin ALB 0.0091
6137 Multidrug resistance-associated protein 6 ABCC6 0.0089
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0089
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0088
6145 Solute carrier family 22 member 1 SLC22A1 0.0087
6142 Solute carrier family 22 member 8 SLC22A8 0.0086
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0085
136 Estrogen receptor ESR1 0.0084
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0084
1898 Cytochrome P450 1B1 CYP1B1 0.0078
6013 Cytochrome P450 2E1 CYP2E1 0.0076
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0075
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0075
2417 Chloramphenicol acetyltransferase cat 0.0071
3278 Chloramphenicol acetyltransferase cat 0.0071
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0067
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0065
6143 Solute carrier family 22 member 7 SLC22A7 0.0065
614 Progesterone receptor PGR 0.0064
3270 Elongation factor G fusA 0.0062
1024 Solute carrier family 22 member 11 SLC22A11 0.0061
275 Arachidonate 5-lipoxygenase ALOX5 0.0061
2808 Chloramphenicol acetyltransferase 3 cat3 0.0061
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.006
908 Glutathione S-transferase theta-1 GSTT1 0.006
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0058
6024 Cytochrome P450 1A1 CYP1A1 0.0055
24 Thymidylate synthase TMP1 0.0055
359 Thymidylate synthase TYMS 0.0055
2626 Thymidylate synthase thyA 0.0055
2729 Thymidylate synthase thyA 0.0055
5352 Thymidylate synthase THYA 0.0055
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0054
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0053
6136 Multidrug resistance-associated protein 5 ABCC5 0.0052
738 Monocarboxylate transporter 1 SLC16A1 0.0052
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0051
238 Peroxisome proliferator-activated receptor gamma PPARG 0.005
5626 Nucleoside diphosphate kinase B NME2 0.0048
904 Glutathione S-transferase P GSTP1 0.0047
6163 Copper-transporting ATPase 2 ATP7B 0.0046
6165 Copper-transporting ATPase 1 ATP7A 0.0046
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0044
6147 Solute carrier family 22 member 3 SLC22A3 0.0044
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0044
6146 High affinity copper uptake protein 1 SLC31A1 0.0044
833 Organic cation/carnitine transporter 1 SLC22A4 0.0043
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0042
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0042
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0042
896 Glutathione S-transferase Mu 1 GSTM1 0.0042
4604 Liver carboxylesterase 1 CES1 0.0042
1629 Transcription factor AP-1 JUN 0.0041
731 HIV-1 protease HIV-1 protease 0.0041
3947 Xanthine dehydrogenase/oxidase XDH 0.004
5294 Nucleoside diphosphate kinase A NME1 0.0039
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0039
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
5718 Cytochrome P450 2A6 CYP2A6 0.0036
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0036
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0034
1757 Myeloperoxidase MPO 0.0034
5923 Microtubule-associated protein tau MAPT 0.0033
5924 Microtubule-associated protein 4 MAP4 0.0033
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0033
1650 Heme carrier protein 1 SLC46A1 0.0033
468 Cytochrome P450 4A11 CYP4A11 0.0032
1123 Eosinophil cationic protein RNASE3 0.0031
131 Synaptic vesicular amine transporter SLC18A2 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
1852 Microtubule-associated protein 2 MAP2 0.0031
3811 Cytochrome P450 19A1 CYP19A1 0.003
737 Mineralocorticoid receptor NR3C2 0.003
33 Cystine/glutamate transporter SLC7A11 0.003
26 Vascular endothelial growth factor receptor 3 FLT4 0.003
165 FL cytokine receptor FLT3 0.0029
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0029
273 Apoptosis regulator Bcl-2 BCL2 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0029
32 Vascular endothelial growth factor receptor 1 FLT1 0.0028
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0028
777 Tumor necrosis factor TNF 0.0028
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0028
4192 DNA topoisomerase 2-beta TOP2B 0.0028
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0027
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0027
228 Beta platelet-derived growth factor receptor PDGFRB 0.0027
1569 G1/S-specific cyclin-D1 CCND1 0.0027
29 Tubulin beta-1 chain TUBB1 0.0026
1760 Aminopeptidase N ANPEP 0.0025
6843 Aminopeptidase N pepN 0.0025
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0025
504 Mast/stem cell growth factor receptor KIT 0.0025
117 Sterol O-acyltransferase 1 SOAT1 0.0025
6211 Tubulin epsilon chain TUBE1 0.0024
6210 Tubulin delta chain TUBD1 0.0024
6212 Tubulin gamma-1 chain TUBG1 0.0024
146 Androgen receptor AR 0.0024
407 Vascular endothelial growth factor receptor 2 KDR 0.0023
6106 Cytochrome P450 2C18 CYP2C18 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0021
6149 Solute carrier family 22 member 10 SLC22A10 0.0021
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
4120 NADPH--cytochrome P450 reductase POR 0.002
6085 Fatty acid-binding protein, intestinal FABP2 0.002
6167 Organic solute transporter subunit beta OSTB 0.002
6166 Organic solute transporter subunit alpha OSTA 0.002
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.002
1630 Integrin beta-2 ITGB2 0.002
489 Monocarboxylate transporter 2 SLC16A7 0.002
3587 Gastrotropin FABP6 0.002
132 ATP-binding cassette sub-family A member 1 ABCA1 0.002
2539 Tubulin alpha-1 chain TUBA4A 0.002
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0019
6837 Serine/threonine-protein kinase 17B STK17B 0.0019
3917 Methylenetetrahydrofolate reductase MTHFR 0.0019
342 P protein [Includes: DNA-directed DNA polymerase P 0.0018
612 P protein [Includes: DNA-directed DNA polymerase P 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0018
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0018
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0018
1176 Mitogen-activated protein kinase 1 MAPK1 0.0018
2449 Tubulin alpha-3 chain TUBA1A 0.0017
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0017
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0017
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0017
6044 Serum paraoxonase/lactonase 3 PON3 0.0016
6031 Cytochrome P450 3A43 CYP3A43 0.0016
702 UMP-CMP kinase CMPK1 0.0016
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0016
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
6599 HTH-type transcriptional regulator ttgR ttgR 0.0015
3923 Cholinesterase BCHE 0.0015
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0015
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0015
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0015
572 Integrin alpha-L ITGAL 0.0015
2599 Tyrosine-protein kinase HCK HCK 0.0015
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0014
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0014
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0014
357 Carbonic anhydrase 2 CA2 0.0014
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0014
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0014
1353 DNA topoisomerase 1 TOP1 0.0014
3552 DNA topoisomerase 1 topA 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0014
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0014
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0014
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0014
1313 Lactoylglutathione lyase GLO1 0.0014
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0014
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0014
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
4122 Histone deacetylase 2 HDAC2 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
4773 Deoxycytidine kinase DCK 0.0013
7 Nitric oxide synthase, inducible NOS2 0.0013
6218 Pannexin-1 PANX1 0.0013
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0013
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
751 Potassium channel subfamily K member 6 KCNK6 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0012
260 Cytochrome P450 51 ERG11 0.0011
761 Cytochrome P450 51 ERG11 0.0011
3163 Cytochrome P450 51 cyp51 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0011
172 Potassium channel subfamily K member 1 KCNK1 0.0011
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0011
5818 Folate receptor alpha FOLR1 0.0011
6220 Aryl hydrocarbon receptor AHR 0.0011
6042 Prostaglandin reductase 2 PTGR2 0.0011
340 Apoptotic protease-activating factor 1 APAF1 0.0011
84 Nuclear receptor 0B1 NR0B1 0.0011
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0011
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0011
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0011
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0011
6168 Solute carrier family 22 member 16 SLC22A16 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.0011
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.001
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.001
469 Annexin A1 ANXA1 0.001
6043 Putative G-protein coupled receptor 44 GPR44 0.001
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.001
293 Gamma-glutamyl hydrolase GGH 0.001
284 DNA-directed RNA polymerase beta chain rpoB 0.001
5773 DNA-directed RNA polymerase beta chain rpoB 0.001
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.001
825 Arsenical pump-driving ATPase ASNA1 0.001
3435 Arsenical pump-driving ATPase arsA 0.001
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.001
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.001
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.001
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.001
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.001
733 Activin receptor type 1B ACVR1B 0.001
154 AFG3-like protein 2 AFG3L2 0.001
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.001
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.001
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.001
395 ALK tyrosine kinase receptor Not Available 0.001
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.001
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.001
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.001
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0009
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0009
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0009
6493 Cytochrome c oxidase subunit 6C COX6C 0.0009
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0009
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0009
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0009
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0009
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0009
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0009
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0009
6559 Cytochrome c oxidase subunit 2 ctaC 0.0009
6669 Cytochrome c oxidase subunit 2 ctaC 0.0009
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0009
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0009
6558 Cytochrome c oxidase subunit 1 ctaD 0.0009
292 Activin receptor type-1 ACVR1 0.0009
849 Activated CDC42 kinase 1 TNK2 0.0009
380 Cytochrome P450 17A1 CYP17A1 0.0009
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0009
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0009
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0009
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0009
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0009
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0009
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0009
297 Adenylate cyclase type 1 ADCY1 0.0009
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0008
465 Calmodulin CALM1 0.0008
2540 Choloylglycine hydrolase cbh 0.0008
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
2981 Phospholipase A2, membrane associated PLA2G2A 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0008
6501 Fatty acid-binding protein, liver FABP1 0.0008
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
740 Argininosuccinate synthase ASS1 0.0007
865 Argininosuccinate synthase ASS1 0.0007
2680 Argininosuccinate synthase argG 0.0007
3194 Argininosuccinate synthase argG 0.0007
869 Estrogen receptor beta ESR2 0.0007
952 Dipeptidyl peptidase 4 DPP4 0.0007
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0007
3809 Estrogen-related receptor gamma ESRRG 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
6021 Adenosine kinase ADK 0.0007
661 ADP/ATP translocase 1 SLC25A4 0.0007
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0007
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
6020 Aldehyde oxidase AOX1 0.0007
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0007
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0006
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
4041 Microsomal glutathione S-transferase 2 MGST2 0.0006
291 Nitric-oxide synthase, endothelial NOS3 0.0006
871 Glucocorticoid receptor NR3C1 0.0006
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0006
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0006
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0006
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0006
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0006
365 Dihydrofolate reductase DHFR 0.0006
2381 Dihydrofolate reductase DFR1 0.0006
2833 Dihydrofolate reductase Not Available 0.0006
2931 Dihydrofolate reductase folA 0.0006
3544 Dihydrofolate reductase folA 0.0006
3682 Dihydrofolate reductase folA 0.0006
6642 Dihydrofolate reductase folA 0.0006
6756 Dihydrofolate reductase dfrA 0.0006
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0006
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
517 Alcohol dehydrogenase 1C ADH1C 0.0006
207 Glutathione synthetase GSS 0.0006
5269 Glutathione synthetase gshB 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0006
921 Glutamate receptor 2 GRIA2 0.0006
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0006
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0005
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0005
3932 Glutathione S-transferase A2 GSTA2 0.0005
4031 Glutathione S-transferase A1 GSTA1 0.0005
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0005
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
824 Sodium-dependent serotonin transporter SLC6A4 0.0004
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