DT-Web

DB01234 - Dexamethasone


Identification
Name Dexamethasone
Accession Number DB01234 (APRD00674)
Type small molecule
Description An anti-inflammatory 9-fluoro-glucocorticoid. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 392.4611
Groups approved
Monoisotopic Weight 392.199902243
Pharmacology
Indication Injection: for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.
Ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.
Ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus
Topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
Oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy
Intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps
Mechanism of action Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to DNA elements (glucocorticoid response elements) which results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Absorption 80-90%
Protein binding 70%
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Oral, rat LD50: >3 gm/kg. Signs of overdose include retinal toxicity, glaucoma, subcapsular cataract, gastrointestinal bleeding, pancreatitis, aseptic bone necrosis, osteoporosis, myopathies, obesity, edemas, hypertension, proteinuria, diabetes, sleep disturbances, psychiatric syndromes, delayed wound healing, atrophy and fragility of the skin, ecchymosis, and pseudotumor cerebri.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The corticosteroid, dexamethasone, alters the anticoagulant effect, acenocoumarol.
Acetylsalicylic acid The corticosteroid, dexamethasone, may decrease the effect of the salicylate, acetylsalicylic acid.
Ambenonium The corticosteroid, dexamethasone, may decrease the effect of the anticholinesterase, ambenonium.
Aminoglutethimide Aminoglutethimide may decrease the effect of dexamethasone.
Amobarbital The barbiturate, amobarbital, may decrease the effect of the corticosteroid, dexamethasone.
Anisindione The corticosteroid, dexamethasone, alters the anticoagulant effect of anisindione.
Aprepitant Aprepitant may increase the effect and toxicity of dexamethasone.
Aprobarbital The barbiturate, aprobarbital, may decrease the effect of the corticosteroid, dexamethasone.
Butabarbital The barbiturate, butabarbital, may decrease the effect of the corticosteroid, dexamethasone.
Butalbital The barbiturate, butalbital, may decrease the effect of the corticosteroid, dexamethasone.
Butethal The barbiturate, butethal, may decrease the effect of the corticosteroid, dexamethasone.
Dabigatran etexilate P-Glycoprotein inducers such as dexamethasone may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Dicumarol The corticosteroid, dexamethasone, alters the anticoagulant effect of dicumarol.
Dihydroquinidine barbiturate The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, dexamethasone.
Edrophonium The corticosteroid, dexamethasone, may decrease the effect of the anticholinesterase, edrophonium.
Estradiol valerate/Dienogest Affects CYP3A4 metabolism, decreases or effects levels of Estradiol valerate/Dienogest.
Ethotoin The enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, dexamethasone.
Fosphenytoin The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, dexamethasone.
Heptabarbital The barbiturate, heptabarbital, may decrease the effect of the corticosteroid, dexamethasone.
Hexobarbital The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, dexamethasone.
Imatinib Dexamethasone may decrease levels of imatinib.
Lurasidone Concomitant therapy with a CYP3A4 inducer will decrease levels of lurasidone. Coadministration with lurasidone is contraindicated. Will decrease Cmax of lurasidone by 85%.
Magnesium salicylate The corticosteroid, dexamethasone, may decrease the effect of magnesium salicylate.
Mephenytoin The enzyme inducer, mephenytoin, may decrease the effect of the corticosteroid, dexamethasone.
Methohexital The barbiturate, methohexital, may decrease the effect of the corticosteroid, dexamethasone.
Methylphenobarbital The barbiturate, methylphenobarbital, may decrease the effect of the corticosteroid, dexamethasone.
Midodrine Increased arterial pressure
Neostigmine The corticosteroid, dexamethasone, may decrease the effect of the anticholinesterase, neostigmine.
Pentobarbital The barbiturate, pentobarbital, may decrease the effect of the corticosteroid, dexamethasone.
Phenobarbital The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, dexamethasone.
Phenytoin The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, dexamethasone.
Primidone The barbiturate, primidone, may decrease the effect of the corticosteroid, dexamethasone.
Pyridostigmine The corticosteroid, dexamethasone, may decrease the effect of the anticholinesterase, pyridostigmine.
Quinidine barbiturate The barbiturate, quinidine barbiturate, may decrease the effect of the corticosteroid, dexamethasone.
Rifampin The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, dexamethasone.
Rilpivirine Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Roflumilast Affects CYP3A4 metabolism, decreases level or effect of roflumilast.
Salsalate The corticosteroid, dexamethasone, may decrease the effect of the salicylate, salsalate.
Secobarbital The barbiturate, secobarbital, may decrease the effect of the corticosteroid, dexamethasone.
Sunitinib Possible decrease in sunitinib levels
Tacrine Tacrine and Dexamethasone may independently exacerbate muscle weakness in myasthenia gravis patients. Monitor for additive muscle weakness effects.
Talbutal The barbiturate, talbutal, may decrease the effect of the corticosteroid, dexamethasone.
Telithromycin Co-administration may cause decreased Telithromycin and increased Dexamethasone plasma concentrations. Consider alternate therapy.
Temsirolimus Dexamethasone may increase the metabolism of Temsirolimus decreasing its efficacy. Concomitant therapy should be avoided.
Thalidomide Increased risk of dermatologic adverse effects and venous thromboembolic events (VTE). Consider VTE prophylaxis during concomitant therapy and monitor for adverse dematologic effects.
Tramadol Dexamethasone may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Trazodone The CYP3A4 inducer, Dexamethasone, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Dexamethasone is initiated, discontinued or dose changed.
Vandetanib Decreases levels of vandetanib by affecting CYP3A4 metabolism. Contraindicated.
Vecuronium Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Dexamethasone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of dexamethasone by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of dexamethasone if voriconazole is initiated, discontinued or dose changed.
Warfarin The corticosteroid, dexamethasone, alters the anticoagulant effect of warfarin.
Food Interactions
  • Take with food to reduce irritation.
  • Avoid alcohol.
  • Avoid taking with grapefruit juice.

Targets


Glucocorticoid receptor
Name Glucocorticoid receptor
Gene Name NR3C1
Pharmacological action yes
Actions agonist
References
  • Warne JP, John CD, Christian HC, Morris JF, Flower RJ, Sugden D, Solito E, Gillies GE, Buckingham JC: Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1264-73. Epub 2006 Jul 11. - Pubmed
  • Grossman R, Yehuda R, Golier J, McEwen B, Harvey P, Maria NS: Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects. Ann N Y Acad Sci. 2006 Jul;1071:410-21. - Pubmed
  • Funato H, Kobayashi A, Watanabe Y: Differential effects of antidepressants on dexamethasone-induced nuclear translocation and expression of glucocorticoid receptor. Brain Res. 2006 Oct 30;1117(1):125-34. Epub 2006 Sep 7. - Pubmed
  • Vaitkuviene A, Ulinskaite A, Meskys R, Duburs G, Klusa V, Liutkevicius E: Study of the interaction of 1,4-dihydropyridine derivatives with glucocorticoid hormone receptors from the rat liver. Pharmacol Rep. 2006 Jul-Aug;58(4):551-8. - Pubmed
  • Wang D, Zhang H, Lang F, Yun CC: Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor. Am J Physiol Cell Physiol. 2007 Jan;292(1):C396-404. Epub 2006 Sep 13. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.0637
Nuclear receptor 0B1
Name Nuclear receptor 0B1
Gene Name NR0B1
Pharmacological action unknown
Actions stimulator
References
  • Gummow BM, Scheys JO, Cancelli VR, Hammer GD: Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex. Mol Endocrinol. 2006 Nov;20(11):2711-23. Epub 2006 Jul 20. - Pubmed
  • Yu CC, Li PH: In vivo inhibition of steroidogenic acute regulatory protein expression by dexamethasone parallels induction of the negative transcription factor DAX-1. Endocrine. 2006 Dec;30(3):313-23. - Pubmed
DTHybrid score 0.1518
Annexin A1
Name Annexin A1
Gene Name ANXA1
Pharmacological action unknown
Actions agonist
References
  • Morand EF, Hall P, Hutchinson P, Yang YH: Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. Mediators Inflamm. 2006;2006(2):73835. - Pubmed
  • John CD, Theogaraj E, Christian HC, Morris JF, Smith SF, Buckingham JC: Time-specific effects of perinatal glucocorticoid treatment on anterior pituitary morphology, annexin 1 expression and adrenocorticotrophic hormone secretion in the adult female rat. J Neuroendocrinol. 2006 Dec;18(12):949-59. - Pubmed
  • Davies E, Omer S, Buckingham JC, Morris JF, Christian HC: Expression and externalization of annexin 1 in the adrenal gland: structure and function of the adrenal gland in annexin 1-null mutant mice. Endocrinology. 2007 Mar;148(3):1030-8. Epub 2006 Dec 7. - Pubmed
  • Wang C, Wang J, Guo HF, Liu RY: Involvement of annexin I in the dexamethasone-mediated upregulation of A549 cells phagocytosis of apoptotic eosinophils. Immunol Lett. 2007 Aug 15;111(2):103-10. Epub 2007 Jul 2. - Pubmed
DTHybrid score 0.4931
Nitric oxide synthase, inducible
Name Nitric oxide synthase, inducible
Gene Name NOS2
Pharmacological action unknown
Actions negative modulator
References
  • Soderberg M, Raffalli-Mathieu F, Lang MA: Regulation of the murine inducible nitric oxide synthase gene by dexamethasone involves a heterogeneous nuclear ribonucleoprotein I (hnRNPI) dependent pathway. Mol Immunol. 2007 May;44(12):3204-10. Epub 2007 Mar 26. - Pubmed
  • Huang H, Lavoie-Lamoureux A, Moran K, Lavoie JP: IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1147-54. - Pubmed
  • Nandi J, Saud B, Zinkievich JM, Palma DT, Levine RA: 5-Aminosalicylic Acid Improves Indomethacin-Induced Enteropathy by Inhibiting iNOS Transcription in Rats. Dig Dis Sci. 2007 May 15;. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.1924

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. - Pubmed
DTHybrid score 1.4572
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate,inducer
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7933
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate,inducer
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6336
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inducer
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.9236
Cholesterol side-chain cleavage enzyme, mitochondrial
Name Cholesterol side-chain cleavage enzyme, mitochondrial
Gene Name CYP11A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3117
Cytochrome P450 17A1
Name Cytochrome P450 17A1
Gene Name CYP17A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.247
Cytochrome P450 19A1
Name Cytochrome P450 19A1
Gene Name CYP19A1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5275
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5465
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.319
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5394
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.602
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8259
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7743
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8941
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.561
Cytochrome P450 3A43
Name Cytochrome P450 3A43
Gene Name CYP3A43
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2389
Cytochrome P450 4A11
Name Cytochrome P450 4A11
Gene Name CYP4A11
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2426

Transporters


Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions inducer
References
  • Fardel O, Payen L, Courtois A, Vernhet L, Lecureur V: Regulation of biliary drug efflux pump expression by hormones and xenobiotics. Toxicology. 2001 Oct 5;167(1):37-46. - Pubmed
DTHybrid score 0.3199
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor,inducer
References
  • Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31. - Pubmed
  • Romiti N, Tramonti G, Chieli E: Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):83-91. - Pubmed
  • Schuetz JD, Silverman JA, Thottassery JV, Furuya KN, Schuetz EG: Divergent regulation of the class II P-glycoprotein gene in primary cultures of hepatocytes versus H35 hepatoma by glucocorticoids. Cell Growth Differ. 1995 Oct;6(10):1321-32. - Pubmed
  • Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
  • Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed
  • Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. - Pubmed
  • Yates CR, Chang C, Kearbey JD, Yasuda K, Schuetz EG, Miller DD, Dalton JT, Swaan PW: Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. - Pubmed
  • Schinkel AH, Wagenaar E, van Deemter L, Mol CA, Borst P: Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest. 1995 Oct;96(4):1698-705. - Pubmed
DTHybrid score 0.9454
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inducer
References
  • Demeule M, Jodoin J, Beaulieu E, Brossard M, Beliveau R: Dexamethasone modulation of multidrug transporters in normal tissues. FEBS Lett. 1999 Jan 15;442(2-3):208-14. - Pubmed
  • Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM: Up-regulation of transporters of the MRP family by drugs and toxins. Toxicol Lett. 2001 Mar 31;120(1-3):51-7. - Pubmed
DTHybrid score 0.4001
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions inhibitor
References
  • Kullak-Ublick GA, Fisch T, Oswald M, Hagenbuch B, Meier PJ, Beuers U, Paumgartner G: Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain. FEBS Lett. 1998 Mar 13;424(3):173-6. - Pubmed
  • Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. - Pubmed
DTHybrid score 0.4281
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Elahian F, Kalalinia F, Behravan J: Evaluation of indomethacin and dexamethasone effects on BCRP-mediated drug resistance in MCF-7 parental and resistant cell lines. Drug Chem Toxicol. 2010 Apr;33(2):113-9. - Pubmed
DTHybrid score 0.4727

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.6733
232 Corticosteroid-binding globulin SERPINA6 0.2647
587 Serum albumin ALB 0.2361
862 Multidrug resistance-associated protein 1 ABCC1 0.2308
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.223
6106 Cytochrome P450 2C18 CYP2C18 0.1979
291 Nitric-oxide synthase, endothelial NOS3 0.1726
20 Prostaglandin G/H synthase 1 PTGS1 0.1725
146 Androgen receptor AR 0.151
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.1482
136 Estrogen receptor ESR1 0.1446
1729 Solute carrier family 22 member 6 SLC22A6 0.1425
756 Sex hormone-binding globulin SHBG 0.1398
6145 Solute carrier family 22 member 1 SLC22A1 0.136
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.1336
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1324
6144 Solute carrier family 22 member 2 SLC22A2 0.1307
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1296
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.1182
492 Histamine H1 receptor HRH1 0.1139
6142 Solute carrier family 22 member 8 SLC22A8 0.1132
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.1127
6141 Sodium/bile acid cotransporter SLC10A1 0.1122
6143 Solute carrier family 22 member 7 SLC22A7 0.1058
76 Nitric-oxide synthase, brain NOS1 0.1042
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.1038
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.1018
824 Sodium-dependent serotonin transporter SLC6A4 0.0984
2164 Multidrug resistance-associated protein 4 ABCC4 0.0971
290 Prostaglandin G/H synthase 2 PTGS2 0.094
118 Organic cation/carnitine transporter 2 SLC22A5 0.0915
260 Cytochrome P450 51 ERG11 0.09
761 Cytochrome P450 51 ERG11 0.09
3163 Cytochrome P450 51 cyp51 0.09
831 D(2) dopamine receptor DRD2 0.0865
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0845
737 Mineralocorticoid receptor NR3C2 0.0843
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0796
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0795
6148 Multidrug resistance-associated protein 7 ABCC10 0.0787
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0785
6147 Solute carrier family 22 member 3 SLC22A3 0.0779
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0772
614 Progesterone receptor PGR 0.0753
502 5-hydroxytryptamine 2A receptor HTR2A 0.0732
556 Alpha-1A adrenergic receptor ADRA1A 0.072
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.071
847 Mu-type opioid receptor OPRM1 0.0701
817 DNA topoisomerase 2-alpha TOP2A 0.0672
3941 Amine oxidase [flavin-containing] A MAOA 0.0668
731 HIV-1 protease HIV-1 protease 0.0661
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0633
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0632
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0626
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0608
766 Beta-2 adrenergic receptor ADRB2 0.0601
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0599
3947 Xanthine dehydrogenase/oxidase XDH 0.0595
1024 Solute carrier family 22 member 11 SLC22A11 0.0587
6137 Multidrug resistance-associated protein 6 ABCC6 0.0583
3923 Cholinesterase BCHE 0.0577
320 5-hydroxytryptamine 1A receptor HTR1A 0.0576
833 Organic cation/carnitine transporter 1 SLC22A4 0.0573
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0571
770 Retinoic acid-induced protein 3 GPRC5A 0.0563
719 Retinoic acid receptor responder protein 1 RARRES1 0.0563
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0562
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0562
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0542
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0542
713 Sodium-dependent dopamine transporter SLC6A3 0.0535
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0531
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0529
6136 Multidrug resistance-associated protein 5 ABCC5 0.0528
341 5-hydroxytryptamine 3 receptor HTR3A 0.052
467 Delta-type opioid receptor OPRD1 0.052
590 5-hydroxytryptamine 2C receptor HTR2C 0.0497
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0494
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0492
318 Alpha-2A adrenergic receptor ADRA2A 0.049
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0488
465 Calmodulin CALM1 0.0483
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0481
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0476
696 Kappa-type opioid receptor OPRK1 0.0474
844 Epidermal growth factor receptor EGFR 0.0473
6014 Cytochrome P450 2A13 CYP2A13 0.0469
569 Retinal dehydrogenase 2 ALDH1A2 0.0467
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0466
193 Beta-1 adrenergic receptor ADRB1 0.0465
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0464
632 Alpha-1B adrenergic receptor ADRA1B 0.0463
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0455
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0451
3939 Amine oxidase [flavin-containing] B MAOB 0.045
4604 Liver carboxylesterase 1 CES1 0.045
23 D(1A) dopamine receptor DRD1 0.0447
6182 Cytochrome P450 2J2 CYP2J2 0.0439
869 Estrogen receptor beta ESR2 0.0438
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0436
780 Retinoic acid receptor RXR-gamma RXRG 0.0432
611 Retinal dehydrogenase 1 ALDH1A1 0.0427
94 5-hydroxytryptamine 4 receptor HTR4 0.0426
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0419
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0415
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0413
504 Mast/stem cell growth factor receptor KIT 0.041
33 Cystine/glutamate transporter SLC7A11 0.0407
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0406
1010 Cytochrome P450 51A1 CYP51A1 0.04
4120 NADPH--cytochrome P450 reductase POR 0.0397
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0395
88 Retinoic acid receptor RXR-beta RXRB 0.0394
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0393
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0386
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0384
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0382
70 Type-1 angiotensin II receptor AGTR1 0.0381
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0376
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0373
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0371
638 D(3) dopamine receptor DRD3 0.0365
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.036
162 Retinoic acid receptor gamma-1 RARG 0.0359
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0353
29 Tubulin beta-1 chain TUBB1 0.0352
885 5-hydroxytryptamine 1B receptor HTR1B 0.0351
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.035
6220 Aryl hydrocarbon receptor AHR 0.035
904 Glutathione S-transferase P GSTP1 0.0345
208 DNA-directed RNA polymerase beta' chain rpoC 0.0339
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0339
1757 Myeloperoxidase MPO 0.0335
1050 Bile salt sulfotransferase SULT2A1 0.0332
4116 Dihydropteroate synthetase Not Available 0.033
122 P2Y purinoceptor 12 P2RY12 0.0322
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.032
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0319
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0317
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0317
3932 Glutathione S-transferase A2 GSTA2 0.0311
563 Thyroid peroxidase TPO 0.0311
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0305
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0304
228 Beta platelet-derived growth factor receptor PDGFRB 0.0302
161 Tubulin beta chain TUBB 0.0302
312 Tubulin beta chain TUB2 0.0302
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0297
777 Tumor necrosis factor TNF 0.0293
6167 Organic solute transporter subunit beta OSTB 0.0293
6166 Organic solute transporter subunit alpha OSTA 0.0292
629 Alpha-2B adrenergic receptor ADRA2B 0.0292
85 Growth hormone receptor GHR 0.0291
725 5-hydroxytryptamine 1D receptor HTR1D 0.0289
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0287
482 Glycine receptor subunit alpha-1 GLRA1 0.0286
723 Cytosolic phospholipase A2 PLA2G4A 0.0285
738 Monocarboxylate transporter 1 SLC16A1 0.0283
789 Alpha-1D adrenergic receptor ADRA1D 0.0281
373 Transthyretin TTR 0.028
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0278
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0278
891 Dihydropteroate synthase folP 0.0276
5359 Dihydropteroate synthase folP 0.0276
7175 Dihydropteroate synthase sulI 0.0276
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0271
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0271
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.027
407 Vascular endothelial growth factor receptor 2 KDR 0.0269
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0267
1852 Microtubule-associated protein 2 MAP2 0.0263
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0262
6174 50S ribosomal protein L32 rpmF 0.0261
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0261
1192 Sulfotransferase 1A1 SULT1A1 0.026
811 Translocator protein TSPO 0.0259
477 DNA topoisomerase 4 subunit A parC 0.0259
886 DNA topoisomerase 4 subunit A parC 0.0259
6226 DNA topoisomerase 4 subunit A parC 0.0259
1178 Adenosine A2a receptor ADORA2A 0.0258
4773 Deoxycytidine kinase DCK 0.0257
26 Vascular endothelial growth factor receptor 3 FLT4 0.0256
5923 Microtubule-associated protein tau MAPT 0.0256
5924 Microtubule-associated protein 4 MAP4 0.0256
273 Apoptosis regulator Bcl-2 BCL2 0.0255
404 DNA gyrase subunit A gyrA 0.0255
6224 DNA gyrase subunit A gyrA 0.0255
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0254
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0252
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0252
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0252
6102 Arylamine N-acetyltransferase 2 NAT2 0.0252
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.025
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.025
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0247
908 Glutathione S-transferase theta-1 GSTT1 0.0246
6146 High affinity copper uptake protein 1 SLC31A1 0.0246
5934 Cytochrome P450 26A1 CYP26A1 0.0245
32 Vascular endothelial growth factor receptor 1 FLT1 0.0245
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0244
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0243
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0243
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0243
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0243
2808 Chloramphenicol acetyltransferase 3 cat3 0.0243
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0243
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0242
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0242
1353 DNA topoisomerase 1 TOP1 0.0239
3552 DNA topoisomerase 1 topA 0.0239
4311 tRNA TRDMT1 0.0238
4325 tRNA trmD 0.0238
4328 tRNA trmD 0.0238
378 Alpha-2C adrenergic receptor ADRA2C 0.0237
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0229
1656 CYP2B protein CYP2B 0.0229
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0226
251 Alcohol dehydrogenase 1A ADH1A 0.0225
131 Synaptic vesicular amine transporter SLC18A2 0.0224
6020 Aldehyde oxidase AOX1 0.0222
828 Phenylalanine-4-hydroxylase PAH 0.0221
3109 Phenylalanine-4-hydroxylase phhA 0.0221
432 D(4) dopamine receptor DRD4 0.022
284 DNA-directed RNA polymerase beta chain rpoB 0.0219
5773 DNA-directed RNA polymerase beta chain rpoB 0.0219
3809 Estrogen-related receptor gamma ESRRG 0.0219
16 Adenosine A1 receptor ADORA1 0.0219
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0217
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0215
2539 Tubulin alpha-1 chain TUBA4A 0.0213
705 Glutamate receptor 1 GRIA1 0.0212
1629 Transcription factor AP-1 JUN 0.0212
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0211
444 Alcohol dehydrogenase 1B ADH1B 0.021
4203 Histamine N-methyltransferase HNMT 0.021
49 Endothelin B receptor EDNRB 0.0209
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0208
716 5-hydroxytryptamine 7 receptor HTR7 0.0208
6044 Serum paraoxonase/lactonase 3 PON3 0.0208
6163 Copper-transporting ATPase 2 ATP7B 0.0207
6165 Copper-transporting ATPase 1 ATP7A 0.0207
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0207
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0206
634 Squalene monooxygenase SQLE 0.0206
7196 Squalene monooxygenase ERG1 0.0206
124 Histamine H2 receptor HRH2 0.0205
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0205
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0204
683 Potassium transporter GK0582 0.0203
275 Arachidonate 5-lipoxygenase ALOX5 0.02
226 Gonadotropin-releasing hormone receptor GNRHR 0.02
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0199
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0198
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
517 Alcohol dehydrogenase 1C ADH1C 0.0198
165 FL cytokine receptor FLT3 0.0197
578 Endothelin-1 receptor EDNRA 0.0197
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0195
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0193
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0192
3587 Gastrotropin FABP6 0.0191
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0191
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0191
921 Glutamate receptor 2 GRIA2 0.019
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0189
436 5-hydroxytryptamine 2B receptor HTR2B 0.0189
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0188
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0187
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0186
2449 Tubulin alpha-3 chain TUBA1A 0.0185
244 Angiotensin-converting enzyme ACE 0.0184
3810 Catechol O-methyltransferase COMT 0.0183
6085 Fatty acid-binding protein, intestinal FABP2 0.0183
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0183
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0182
4237 50S ribosomal protein L22 rplV 0.0182
3270 Elongation factor G fusA 0.0181
134 Tryptophan 5-hydroxylase 1 TPH1 0.018
3426 Glutamine synthetase glnA 0.018
3987 Glutamine synthetase GLUL 0.018
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.018
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0179
896 Glutathione S-transferase Mu 1 GSTM1 0.0179
1483 Membrane copper amine oxidase AOC3 0.0178
4238 50S ribosomal protein L4 rplD 0.0177
5578 50S ribosomal protein L4 rplD 0.0177
6173 50S ribosomal protein L4 rplD 0.0177
6219 50S ribosomal protein L4 rplD 0.0177
4122 Histone deacetylase 2 HDAC2 0.0176
537 ATP synthase delta chain, mitochondrial ATP5D 0.0175
148 Lutropin-choriogonadotropic hormone receptor LHCGR 0.0175
13 Aminomethyltransferase, mitochondrial AMT 0.0174
4228 Keratin, type II cytoskeletal 7 KRT7 0.0174
3913 Glutamic acid decarboxylase GAD65 0.0173
952 Dipeptidyl peptidase 4 DPP4 0.0172
474 Acetylcholinesterase ACHE 0.017
4192 DNA topoisomerase 2-beta TOP2B 0.0169
581 Cytochrome P450 2R1 CYP2R1 0.0169
823 Fibroblast growth factor receptor 2 FGFR2 0.0169
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0169
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0168
365 Dihydrofolate reductase DHFR 0.0167
2381 Dihydrofolate reductase DFR1 0.0167
2833 Dihydrofolate reductase Not Available 0.0167
2931 Dihydrofolate reductase folA 0.0167
3544 Dihydrofolate reductase folA 0.0167
3682 Dihydrofolate reductase folA 0.0167
6642 Dihydrofolate reductase folA 0.0167
6756 Dihydrofolate reductase dfrA 0.0167
818 50S ribosomal protein L10 rplJ 0.0167
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0167
1517 Beta-3 adrenergic receptor ADRB3 0.0166
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0166
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0165
24 Thymidylate synthase TMP1 0.0165
359 Thymidylate synthase TYMS 0.0165
2626 Thymidylate synthase thyA 0.0165
2729 Thymidylate synthase thyA 0.0165
5352 Thymidylate synthase THYA 0.0165
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0164
820 Glycine receptor subunit alpha-2 GLRA2 0.0163
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0163
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0162
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0162
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0159
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0158
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0157
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0157
887 DNA gyrase subunit B gyrB 0.0156
4150 DNA gyrase subunit B gyrB 0.0156
6225 DNA gyrase subunit B gyrB 0.0156
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0155
174 Sigma 1-type opioid receptor SIGMAR1 0.0154
427 Substance-P receptor TACR1 0.0154
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0153
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0153
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0153
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0153
295 Carbonic anhydrase 1 CA1 0.0152
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0151
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0151
2617 Nitric oxide synthase oxygenase nos 0.015
2701 Nitric oxide synthase oxygenase nos 0.015
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.015
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.015
814 Ryanodine receptor 1 RYR1 0.0149
528 5-hydroxytryptamine 1E receptor HTR1E 0.0148
68 Cannabinoid receptor 1 CNR1 0.0148
1992 Vitamin D-binding protein GC 0.0147
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0147
613 Atrial natriuretic peptide receptor A NPR1 0.0146
1256 5-hydroxytryptamine 6 receptor HTR6 0.0146
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0145
3904 Alanine aminotransferase 2 GPT2 0.0145
735 Alanine aminotransferase 1 GPT 0.0145
571 Melatonin receptor type 1A MTNR1A 0.0143
362 Melatonin receptor type 1B MTNR1B 0.0143
856 Vitamin D3 receptor VDR 0.0142
381 Prolactin receptor PRLR 0.0142
3957 Adenosine deaminase ADA 0.0141
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0138
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0136
5787 Angiopoietin-1 receptor TEK 0.0133
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0132
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0131
185 Vasopressin V1a receptor AVPR1A 0.0131
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0131
2499 Tubulin beta-2C chain TUBB2C 0.0129
117 Sterol O-acyltransferase 1 SOAT1 0.0129
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0128
2675 Pteridine reductase 1 PTR1 0.0128
322 Vasopressin V2 receptor AVPR2 0.0128
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0127
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0127
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0127
3917 Methylenetetrahydrofolate reductase MTHFR 0.0127
2112 Toll-like receptor 9 TLR9 0.0126
106 Cannabinoid receptor 2 CNR2 0.0125
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0125
592 Carbonic anhydrase 4 CA4 0.0125
1650 Heme carrier protein 1 SLC46A1 0.0123
1630 Integrin beta-2 ITGB2 0.0123
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0123
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0123
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0123
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0122
3856 Fibroblast growth factor receptor 3 FGFR3 0.0121
461 Glycine receptor subunit alpha-3 GLRA3 0.0121
239 Coagulation factor X F10 0.0121
1569 G1/S-specific cyclin-D1 CCND1 0.0121
6599 HTH-type transcriptional regulator ttgR ttgR 0.0121
1714 Mitogen-activated protein kinase 3 MAPK3 0.012
163 D(1B) dopamine receptor DRD5 0.012
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.012
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.012
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.012
976 Platelet glycoprotein IX GP9 0.012
2230 Catalase CAT 0.0119
3249 Catalase katA 0.0119
3625 Catalase katA 0.0119
4539 Catalase katA 0.0119
4941 Catalase katB 0.0119
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0118
1618 High affinity nerve growth factor receptor NTRK1 0.0118
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0117
936 Ephrin type-A receptor 2 EPHA2 0.0116
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0116
511 5-hydroxytryptamine 1F receptor HTR1F 0.0116
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0116
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0116
48 Pyridoxal kinase PDXK 0.0116
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0116
518 Peroxidase/catalase T katG 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0115
319 Opioid receptor, sigma 1 OPRS1 0.0114
183 Vascular endothelial growth factor A VEGFA 0.0114
3830 Calreticulin CALR 0.0113
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0111
267 Plasminogen activator inhibitor 1 SERPINE1 0.0111
751 Potassium channel subfamily K member 6 KCNK6 0.0109
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0108
2443 Azurin azu 0.0108
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0108
357 Carbonic anhydrase 2 CA2 0.0107
2360 Dihydroneopterin aldolase folB 0.0107
6034 Hydroxyindole O-methyltransferase ASMT 0.0105
6035 Nuclear receptor ROR-beta RORB 0.0105
6036 Eosinophil peroxidase EPX 0.0105
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0105
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0105
6138 Multidrug resistance protein 3 ABCB4 0.0105
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0104
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0103
790 DNA polymerase subunit alpha B POLA2 0.0103
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0102
484 Tyrosine-protein kinase ABL2 ABL2 0.0101
315 Arginase-1 ARG1 0.0101
1176 Mitogen-activated protein kinase 1 MAPK1 0.01
6221 Steroid hormone receptor ERR1 ESRRA 0.01
3937 Fatty-acid amide hydrolase FAAH 0.01
172 Potassium channel subfamily K member 1 KCNK1 0.01
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.01
768 FK506-binding protein 1A FKBP1A 0.01
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0099
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0099
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0098
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0098
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0098
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0098
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0098
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0098
594 Thyroxine-binding globulin SERPINA7 0.0098
6168 Solute carrier family 22 member 16 SLC22A16 0.0098
6149 Solute carrier family 22 member 10 SLC22A10 0.0097
5300 Antigen peptide transporter 1 TAP1 0.0096
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0096
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0096
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0096
558 Solute carrier family 12 member 1 SLC12A1 0.0095
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0095
676 Tyrosine 3-monooxygenase TH 0.0095
6126 Carbonic anhydrase 7 CA7 0.0094
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0094
740 Argininosuccinate synthase ASS1 0.0093
865 Argininosuccinate synthase ASS1 0.0093
2680 Argininosuccinate synthase argG 0.0093
3194 Argininosuccinate synthase argG 0.0093
1063 Signal transducer and activator of transcription 5B STAT5B 0.0093
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0093
4615 Chain A, Red Copper Protein Nitrosocyanin NE0143 0.0093
992 Protein tyrosine kinase 2 beta PTK2B 0.0092
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0092
765 Indoleamine 2,3-dioxygenase IDO1 0.0091
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0091
6211 Tubulin epsilon chain TUBE1 0.0091
6210 Tubulin delta chain TUBD1 0.0091
6212 Tubulin gamma-1 chain TUBG1 0.0091
758 Thyroid hormone receptor alpha THRA 0.009
54 Prothrombin F2 0.009
153 Dopamine beta-hydroxylase DBH 0.009
6500 Phospholipase A2 PLA2G1B 0.009
1275 Estrogen sulfotransferase SULT1E1 0.0089
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0089
6043 Putative G-protein coupled receptor 44 GPR44 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
6432 Transporter snf 0.0088
6766 O-GlcNAcase BT_4395 BT_4395 0.0087
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0087
2216 Fibroblast growth factor receptor 4 FGFR4 0.0087
6824 Tyrosine-protein kinase Lyn LYN 0.0084
605 Fumarate reductase flavoprotein subunit frdA 0.0083
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0083
3673 Fumarate reductase flavoprotein subunit fccA 0.0083
4912 Fumarate reductase flavoprotein subunit ifcA 0.0083
6549 Fumarate reductase flavoprotein subunit frdA 0.0083
572 Integrin alpha-L ITGAL 0.0083
2300 Lysozyme E 0.0082
3633 Lysozyme R 0.0082
5597 Lysozyme 17 0.0082
268 Adenosine A2b receptor ADORA2B 0.0082
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0081
850 Vasopressin V1b receptor AVPR1B 0.0081
2236 Casein kinase II subunit alpha CSNK2A1 0.008
346 Thyroid hormone receptor beta-1 THRB 0.008
1196 Complement decay-accelerating factor CD55 0.008
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.008
459 Retinoic acid receptor RXR-alpha RXRA 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
3601 Dihydropteroate synthase 1 folP1 0.0079
3807 Dihydropteroate synthase 1 folP1 0.0079
3808 Dihydropteroate synthase 2 folP2 0.0079
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0078
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0076
144 Hemoglobin subunit alpha HBA1 0.0076
4103 Proteasome subunit beta type 2 PSMB2 0.0075
4102 Proteasome subunit beta type 5 PSMB5 0.0075
4101 Proteasome subunit beta type 1 PSMB1 0.0075
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0075
229 Retinoic acid receptor beta RARB 0.0075
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
1541 Metalloproteinase mmp20 0.0074
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0074
164 Histamine H4 receptor HRH4 0.0073
730 Retinoic acid receptor alpha RARA 0.0073
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0073
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0073
293 Gamma-glutamyl hydrolase GGH 0.0073
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0071
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0071
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0071
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0071
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
4217 Telomerase reverse transcriptase TERT 0.007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.007
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
2981 Phospholipase A2, membrane associated PLA2G2A 0.007
890 Niemann-Pick C1-like protein 1 NPC1L1 0.007
1649 Small inducible cytokine A2 CCL2 0.007
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0069
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0068
5626 Nucleoside diphosphate kinase B NME2 0.0068
1758 GTPase HRas HRAS 0.0068
6151 Monocarboxylate transporter 10 SLC16A10 0.0068
3086 Plasmepsin-2 Not Available 0.0068
105 Sodium-dependent multivitamin transporter SLC5A6 0.0067
1636 Trace amine-associated receptor 1 TAAR1 0.0067
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0067
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0067
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0066
2298 Cytochrome P450-cam camC 0.0065
489 Monocarboxylate transporter 2 SLC16A7 0.0065
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0064
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0064
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0064
473 L-lactate dehydrogenase A chain LDHA 0.0063
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
1760 Aminopeptidase N ANPEP 0.0063
6843 Aminopeptidase N pepN 0.0063
133 Dihydropterate synthase sulI 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
2810 Dr hemagglutinin structural subunit draA 0.0062
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0062
199 Monocarboxylate transporter 8 SLC16A2 0.0062
1291 cAMP response element-binding protein CREB1 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0059
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0059
6033 High affinity interleukin-8 receptor A CXCR1 0.0059
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0059
2232 Interleukin-5 IL5 0.0059
1593 Mucin-2 MUC2 0.0059
4210 Toll-like receptor 4 TLR4 0.0059
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0059
2599 Tyrosine-protein kinase HCK HCK 0.0058
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0058
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
5294 Nucleoside diphosphate kinase A NME1 0.0056
771 Pyruvate carboxylase, mitochondrial PC 0.0056
2320 Thymidine kinase, cytosolic TK1 0.0055
6506 Stathmin-4 STMN4 0.0055
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0054
65 Matrix metalloproteinase-9 Not Available 0.0054
1864 RET proto-oncogene RET 0.0054
6837 Serine/threonine-protein kinase 17B STK17B 0.0054
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0054
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0054
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0054
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0054
1374 Natriuretic peptides B NPPB 0.0053
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0053
1827 Gap junction alpha-1 protein GJA1 0.0053
1908 Vascular cell adhesion protein 1 VCAM1 0.0053
1262 Corticotropin-lipotropin POMC 0.0052
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0052
4226 Uridine phosphorylase 2 UPP2 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
775 Acetyl-CoA carboxylase 2 ACACB 0.0052
6218 Pannexin-1 PANX1 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
577 Argininosuccinate lyase ASL 0.0051
3639 Thymidine phosphorylase deoA 0.0051
3936 Thymidine phosphorylase TYMP 0.0051
5798 Mitogen-activated protein kinase 11 MAPK11 0.0051
400 Coagulation factor IX F9 0.005
5461 Coagulation factor IX F9 0.005
6048 Troponin C, skeletal muscle TNNC2 0.005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0049
1123 Eosinophil cationic protein RNASE3 0.0049
3404 Exotoxin A eta 0.0049
173 Toll-like receptor 7 TLR7 0.0049
2391 Ferrochelatase hemH 0.0048
6502 Ferrochelatase DKFZp686P18130 0.0048
1591 Ferrochelatase, mitochondrial FECH 0.0048
4225 Uridine phosphorylase 1 UPP1 0.0048
1814 Protein-arginine deiminase type-4 PADI4 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0047
1039 Histone deacetylase 9 HDAC9 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
1253 Interferon gamma IFNG 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
1648 Elastin ELN 0.0046
702 UMP-CMP kinase CMPK1 0.0046
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0046
604 Vitamin K-dependent protein Z PROZ 0.0045
843 NG,NG-dimethylarginine dimethylaminohydrolase 1 DDAH1 0.0045
670 NG,NG-dimethylarginine dimethylaminohydrolase 2 DDAH2 0.0045
4066 Protein-arginine deiminase type-1 PADI1 0.0045
4068 Protein-arginine deiminase type-2 PADI2 0.0045
4067 Protein-arginine deiminase type-3 PADI3 0.0045
4065 Protein-arginine deiminase type-6 PADI6 0.0045
527 Prostacyclin receptor PTGIR 0.0045
834 Arginase-2, mitochondrial ARG2 0.0045
718 Folate receptor gamma FOLR3 0.0045
804 Mitochondrial folate transporter/carrier SLC25A32 0.0045
299 Folate receptor beta FOLR2 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
413 Amidophosphoribosyltransferase PPAT 0.0045
2515 Amidophosphoribosyltransferase purF 0.0045
3714 Amidophosphoribosyltransferase purF 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
1360 Sphingomyelin phosphodiesterase SMPD1 0.0045
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0044
1268 Neuropeptide S receptor NPSR1 0.0044
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0044
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0044
2021 Thrombomodulin THBD 0.0044
130 Prostacyclin synthase PTGIS 0.0044
1820 Beta-nerve growth factor NGF 0.0044
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0043
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0043
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0043
2207 Rhodopsin RHO 0.0043
499 Arginine decarboxylase ADC 0.0042
336 Ornithine carbamoyltransferase, mitochondrial OTC 0.0042
422 Vitamin K-dependent protein C PROC 0.0042
1245 Vitamin K-dependent protein S PROS1 0.0042
6493 Cytochrome c oxidase subunit 6C COX6C 0.0041
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0041
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0041
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0041
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0041
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0041
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0041
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0041
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0041
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0041
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0041
6559 Cytochrome c oxidase subunit 2 ctaC 0.0041
6669 Cytochrome c oxidase subunit 2 ctaC 0.0041
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0041
6558 Cytochrome c oxidase subunit 1 ctaD 0.0041
342 P protein [Includes: DNA-directed DNA polymerase P 0.0041
612 P protein [Includes: DNA-directed DNA polymerase P 0.0041
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.004
6073 Potassium channel subfamily K member 9 KCNK9 0.004
6072 Potassium channel subfamily K member 3 KCNK3 0.004
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
150 Cationic amino acid transporter 3 SLC7A3 0.0039
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0039
58 Cationic amino acid transporter 4 SLC7A4 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
5818 Folate receptor alpha FOLR1 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0039
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0039
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
2540 Choloylglycine hydrolase cbh 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
6042 Prostaglandin reductase 2 PTGR2 0.0038
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0037
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
2782 Complement C1s subcomponent C1S 0.0037
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
6131 Carbonic anhydrase 14 CA14 0.0036
6501 Fatty acid-binding protein, liver FABP1 0.0035
340 Apoptotic protease-activating factor 1 APAF1 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0034
3815 Complement C1q subcomponent subunit A C1QA 0.0034
3816 Complement C1q subcomponent subunit B C1QB 0.0034
3817 Complement C1q subcomponent subunit C C1QC 0.0034
1313 Lactoylglutathione lyase GLO1 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0034
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0034
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0034
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0034
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0034
3814 Complement C1r subcomponent C1R 0.0034
798 Osteocalcin BGLAP 0.0034
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0034
6122 Carbonic anhydrase 3 CA3 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
5880 Thrombopoietin receptor MPL 0.0033
627 11-cis retinol dehydrogenase RDH5 0.0033
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0033
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0032
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0031
825 Arsenical pump-driving ATPase ASNA1 0.0031
3435 Arsenical pump-driving ATPase arsA 0.0031
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0031
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0031
154 AFG3-like protein 2 AFG3L2 0.0031
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0031
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0031
733 Activin receptor type 1B ACVR1B 0.0031
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0031
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0031
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0031
395 ALK tyrosine kinase receptor Not Available 0.0031
760 Fibroblast growth factor 1 FGF1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
358 Cystathionine beta-synthase CBS 0.0031
369 Coagulation factor VII F7 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
1792 Tissue-type plasminogen activator PLAT 0.003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.003
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
822 Aldose reductase AKR1B1 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
292 Activin receptor type-1 ACVR1 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
6459 Glycodelin PAEP 0.0028
849 Activated CDC42 kinase 1 TNK2 0.0028
3221 Cytochrome c4 cc4 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0027
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0027
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0027
297 Adenylate cyclase type 1 ADCY1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0027
816 Biliverdin reductase A BLVRA 0.0027
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0027
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0027
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
2408 Tyrosine-protein kinase SYK SYK 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
810 Heme oxygenase 1 HMOX1 0.0025
3391 Heme oxygenase 1 pbsA1 0.0025
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0025
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0025
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0025
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0025
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0025
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0025
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0025
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0025
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0025
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0025
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0025
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0025
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0025
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0025
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0025
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0025
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0025
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0025
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0025
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0025
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0025
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0025
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0025
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0025
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0025
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0025
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0025
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0025
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0025
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0025
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0025
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0025
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0025
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0025
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0025
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0025
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0025
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0025
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0025
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0025
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0025
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0025
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0025
644 Heme oxygenase 2 HMOX2 0.0025
4982 Heme oxygenase 2 pbsA2 0.0025
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0025
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0025
167 L-lactate dehydrogenase C chain LDHC 0.0025
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0025
729 GDP-L-fucose synthetase TSTA3 0.0025
3463 GDP-L-fucose synthetase fcl 0.0025
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0025
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0025
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0025
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0025
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0025
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0025
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0025
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0025
3726 D-3-phosphoglycerate dehydrogenase serA 0.0025
4291 D-3-phosphoglycerate dehydrogenase serA 0.0025
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0025
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0025
206 3-keto-steroid reductase HSD17B7 0.0025
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0025
34 7-dehydrocholesterol reductase DHCR7 0.0025
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0025
711 UDP-glucose 6-dehydrogenase UGDH 0.0025
3672 UDP-glucose 6-dehydrogenase hasB 0.0025
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0025
107 C-4 methylsterol oxidase SC4MOL 0.0025
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0025
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0025
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0025
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0025
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0025
643 Peroxisomal bifunctional enzyme EHHADH 0.0025
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0025
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
3007 Carbonic anhydrase 12 CA12 0.0025
4205 Carbonic anhydrase 9 CA9 0.0025
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
646 Malate dehydrogenase, cytoplasmic MDH1 0.0024
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0024
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0024
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0024
396 Alcohol dehydrogenase 4 ADH4 0.0024
328 Sorbitol dehydrogenase SORD 0.0024
597 Dihydropteridine reductase QDPR 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
3955 Cell division protein kinase 6 CDK6 0.0023
6228 Nuclear receptor coactivator 1 NCOA1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
6241 Nuclear receptor coactivator 2 NCOA2 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
1341 Histamine H3 receptor HRH3 0.0023
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0023
666 NADP-dependent malic enzyme ME1 0.0023
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0023
661 ADP/ATP translocase 1 SLC25A4 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
6021 Adenosine kinase ADK 0.0023
857 Malate dehydrogenase, mitochondrial MDH2 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0022
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
77 L-lactate dehydrogenase B chain LDHB 0.0022
12 Alcohol dehydrogenase class 3 ADH5 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
997 Protein kinase C beta type PRKCB 0.0021
298 Renin REN 0.0021
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0021
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0021
6026 Alcohol dehydrogenase 6 ADH6 0.0021
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0021
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0021
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0021
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0021
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0021
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0021
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0021
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0021
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0021
626 Cysteine dioxygenase type 1 CDO1 0.0021
714 Glutathione reductase, mitochondrial GSR 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0021
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.002
1970 Protein kinase C alpha type PRKCA 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1058 Cell division protein kinase 5 CDK5 0.002
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0019
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0019
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0019
4948 Cytochrome c-553 Not Available 0.0018
4923 Cytochrome c3 DvMF_2499 0.0018
4945 Cytochrome c3 Not Available 0.0018
4949 Cytochrome c3 DVU_3171 0.0018
4968 Cytochrome c3 cytc3 0.0018
4997 Cytochrome c3 SO_2727 0.0018
5219 Cytochrome c3 cyd 0.0018
4902 Nine-heme cytochrome c Ddes_2038 0.0018
3189 High-molecular-weight cytochrome c hmcA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
279 Tyrosinase TYR 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
654 Flavin reductase BLVRB 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
4386 Hemoglobin-like protein HbN glbN 0.0016
4041 Microsomal glutathione S-transferase 2 MGST2 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
4954 Soluble cytochrome b558 Not Available 0.0016
4925 Cytochrome c-type protein SHP shp 0.0016
4915 Cytochrome c-550 psbV 0.0016
4959 Cytochrome c-550 psbV 0.0016
5216 Cytochrome c-550 psbV 0.0016
4934 Cytochrome c-551 nirM 0.0016
5218 Cytochrome c-551 nirM 0.0016
4947 Bacterial hemoglobin vhb 0.0016
4998 Hemoglobin-like protein yjbI yjbI 0.0016
4916 Cyanoglobin glbN 0.0016
4936 Cytochrome c2 iso-2 Not Available 0.0016
4994 Hemoglobin-like protein HbO glbO 0.0016
4943 Cytochrome c6 petJ 0.0016
4984 Neuroglobin NGB 0.0016
4981 Iron-starvation protein PigA pigA 0.0016
4905 Cytochrome c2 Not Available 0.0016
4939 Cytochrome c2 cycA 0.0016
4964 Cytochrome c2 cycA 0.0016
4979 Cytochrome c2 cycA 0.0016
6673 Cytochrome c2 cycA 0.0016
4909 CooA protein cooA 0.0016
4975 Cytochrome c-556 RPA3973 0.0016
4910 Cytoglobin CYGB 0.0016
4942 Diheme cytochrome c napB napB 0.0016
5000 HemO hemO 0.0016
4907 Cytochrome c-L moxG 0.0016
6865 Cytochrome c-L moxG 0.0016
4961 Hemophore HasA hasA 0.0016
4935 Cytochrome c-554 cycA1 0.0016
4971 Nonaheme cytochrome c hmcA 0.0016
4904 Cytochrome c family protein GSU1996 0.0016
4764 Cytochrome P450 165C4 CYP165C4 0.0016
4976 Apocytochrome f petA 0.0016
6407 Apocytochrome f petA 0.0016
4937 Cytochrome oxidase subunit II rcoxA 0.0016
4989 Cytochrome c551 peroxidase ccp 0.0016
5222 Cytochrome c551 peroxidase ccpA 0.0016
4972 P450cin cinA 0.0016
4999 Cytochrome P450 165B3 CYP165B3 0.0016
4922 Cytochrome c, putative SO_4144 0.0016
4960 Putative cytochrome P450-family protein SCO7417 0.0016
4931 Cytochrome P450 167A1 CYP167A1 0.0016
4926 Heme-based aerotactic transducer hemAT hemAT 0.0016
4993 Hydroxylamine oxidoreductase hao1 0.0016
4903 Methyl-accepting chemotaxis protein Tar4 0.0016
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0016
4952 Catalase/peroxidase katA 0.0016
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0016
3093 Catalase HPII katE 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
6677 Myelin P2 protein PMP2 0.0015
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0015
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0013
4031 Glutathione S-transferase A1 GSTA1 0.0013
1507 Cytochrome c CYCS 0.0013
4920 Peroxidase/catalase katG 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
4990 PpcA ppcA 0.0012
2119 Cytochrome b5 CYB5A 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0012
3375 Acidic cytochrome c3 Not Available 0.0012
4385 Cytochrome c' Not Available 0.0012
4967 Cytochrome c' cycA 0.0012
5038 Cytochrome c' Not Available 0.0012
5223 Cytochrome c' cycP 0.0012
4988 Sulfite oxidase, mitochondrial SUOX 0.0012
3570 Cytochrome P450 152A1 cypC 0.0012
2915 Sensor protein fixL fixL 0.0012
4944 Sensor protein fixL fixL 0.0012
4813 Heme oxygenase hmuO 0.0012
5769 Heme oxygenase Not Available 0.0012
4289 Cytochrome P450 TT_P0059 0.0012
6262 Cytochrome P450 staP 0.0012
4992 Cytochrome c peroxidase Not Available 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
6859 Protein S100-A4 S100A4 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
3670 Soluble cytochrome b562 precursor cybC 0.0011
3411 Cytochrome P450 121 cyp121 0.0011
3291 Cytochrome c-552 cycA 0.0011
4927 Cytochrome c-552 nrfA 0.0011
4938 Cytochrome c-552 cycA 0.0011
4953 Cytochrome c-552 nrfA 0.0011
5217 Cytochrome c-552 cycM 0.0011
3102 Flavohemoprotein hmp 0.0011
4969 Flavohemoprotein hmp 0.0011
2802 Endoglucanase G celCCG 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
345 Plasma retinol-binding protein RBP4 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
2972 6-deoxyerythronolide B hydroxylase eryF 0.001
4608 Putative cytochrome P450 SCO1207 0.001
4963 Putative cytochrome P450 SCO2884 0.001
6254 Putative cytochrome P450 SCO6998 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2132 Protein S100-B S100B 0.0009
693 Hemoglobin subunit beta HBB 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6268 Hydroxyacid oxidase 1 HAO1 0.0008
1867 Major prion protein PRNP 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
1830 5'-nucleotidase NT5E 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
125 DNA polymerase beta POLB 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
207 Glutathione synthetase GSS 0.0006
5269 Glutathione synthetase gshB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
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