DT-Web: DB01339

Identification

Name

Vecuronium

Accession Number

DB01339

Type

small molecule

Description

Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

557.8274

Groups

approved

Monoisotopic Weight

557.431833322

Pharmacology

Indication

Vecuronium is a muscle relaxing agent and is used as an ajunct in general anesthesia.

Mechanism of action

Vecuronium is a bisquaternary nitrogen compound that acts by competitively binding to nicotinic cholinergic receptors. The binding of vecuronium decreases the opportunity for acetylcholine to bind to the nicotinic receptor at the postjunctional membrane of the myoneural junction. As a result, depolarization is prevented, calcium ions are not released and muscle contraction does not occur.

Absorption

Not Available

Protein binding

Not Available

Biotransformation

100%

Route of elimination

Fecal (40-75%) and renal (30% as unchanged drug and metabolites)

Toxicity

Not Available

Affected organisms

Not Available

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amikacin	The agent increases the effect of muscle relaxant
Aminophylline	Theophylline decreases the effect of muscle relaxant
Azathioprine	The agent decreases the effect of the muscle relaxant
Betamethasone	Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Betamethasone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
Carbamazepine	Decreases the effect of muscle relaxant
Clindamycin	The agent increases the effect of muscle relaxant
Colistimethate	Colistimethate may increase the neuromuscular blocking action of Vecuronium. Risk of respiratory depression and apnea. Consider alternate therapy or monitor for prolonged neuromuscular blocking effects, such as respiratory paralysis.
Corticotropin	Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Corticotropin. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
Cortisone acetate	Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Cortisone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
Dexamethasone	Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Dexamethasone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
Fludrocortisone	Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Fludrocortisone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
Fosphenytoin	Phenytoin decreases the effect of muscle relaxant
Gentamicin	The agent increases the effect of muscle relaxant
Hydrocortisone	Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Hydrocortisone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
Lincomycin	The agent increases the effect of muscle relaxant
Mercaptopurine	The agent dereases the effect of the muscle relaxant
Methylprednisolone	Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Methylprednisolone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
Netilmicin	The agent increases the effect of muscle relaxant
Oxtriphylline	Theophylline decreases the effect of muscle relaxant
Phenytoin	Phenytoin decreases the effect of the muscle relaxant
Piperacillin	The agent increases the effect of the muscle relaxant
Polymyxin B Sulfate	Polymyxin B may increase the neuromuscular blocking action of Vecuronium. Risk of respiratory depression and apnea. Consider alternate therapy or monitor for prolonged neuromuscular blocking effects, such as respiratory paralysis.
Prednisolone	Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Prednisolone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
Prednisone	Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Prednisone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
Quinidine	The quinine derivative increases the effect of the muscle relaxant
Quinine	Quinine may increase the neuromuscular blocking action of Vecuronium. Risk of respiratory depression and apnea. Concurrent therapy should be avoided.
Theophylline	Theophylline decreases the effect of the muscle relaxant
Tobramycin	The agent increases the effect of the muscle relaxant
Triamcinolone	Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Triamcinolone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.

Food Interactions

Not Available

Neuronal acetylcholine receptor subunit alpha-2
Name	Neuronal acetylcholine receptor subunit alpha-2
Gene Name	CHRNA2
Pharmacological action	yes
Actions	antagonist
References	Jonsson Fagerlund M, Dabrowski M, Eriksson LI: Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. - Pubmed Liu M, Dilger JP: Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33. - Pubmed Paul M, Fokt RM, Kindler CH, Dipp NC, Yost CS: Characterization of the interactions between volatile anesthetics and neuromuscular blockers at the muscle nicotinic acetylcholine receptor. Anesth Analg. 2002 Aug;95(2):362-7, table of contents. - Pubmed
DTHybrid score	0.5729

Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. - Pubmed Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. - Pubmed
DTHybrid score	0.2313
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	Smit JW, Weert B, Schinkel AH, Meijer DK: Heterologous expression of various P-glycoproteins in polarized epithelial cells induces directional transport of small (type 1) and bulky (type 2) cationic drugs. J Pharmacol Exp Ther. 1998 Jul;286(1):321-7. - Pubmed
DTHybrid score	0.2457

Id	Partner name	Gene Name	Score
617	Muscarinic acetylcholine receptor M2	CHRM2	0.1135
4512	Cytochrome P450 3A4	CYP3A4	0.0978
6144	Solute carrier family 22 member 2	SLC22A2	0.0868
3923	Cholinesterase	BCHE	0.0822
4119	Cytochrome P450 2D6	CYP2D6	0.0761
474	Acetylcholinesterase	ACHE	0.0538
4118	Cytochrome P450 3A5	CYP3A5	0.0523
4200	Cytochrome P450 1A2	CYP1A2	0.0466
6016	Cytochrome P450 2C19	CYP2C19	0.0441
4757	Cytochrome P450 2C9	CYP2C9	0.0424
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0402
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0401
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0382
6107	Cytochrome P450 3A7	CYP3A7	0.0373
4924	Cytochrome P450 2C8	CYP2C8	0.0371
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0371
6147	Solute carrier family 22 member 3	SLC22A3	0.0346
118	Organic cation/carnitine transporter 2	SLC22A5	0.0334
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0307
587	Serum albumin	ALB	0.0292
833	Organic cation/carnitine transporter 1	SLC22A4	0.0282
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0282
6030	Cytochrome P450 2B6	CYP2B6	0.0279
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0241
6024	Cytochrome P450 1A1	CYP1A1	0.0236
862	Multidrug resistance-associated protein 1	ABCC1	0.0224
831	D(2) dopamine receptor	DRD2	0.0215
556	Alpha-1A adrenergic receptor	ADRA1A	0.0215
6013	Cytochrome P450 2E1	CYP2E1	0.0212
6142	Solute carrier family 22 member 8	SLC22A8	0.0208
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0189
1729	Solute carrier family 22 member 6	SLC22A6	0.0187
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0178
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0176
723	Cytosolic phospholipase A2	PLA2G4A	0.0171
23	D(1A) dopamine receptor	DRD1	0.0163
776	Bile salt export pump	ABCB11	0.0163
193	Beta-1 adrenergic receptor	ADRB1	0.0158
824	Sodium-dependent serotonin transporter	SLC6A4	0.0157
766	Beta-2 adrenergic receptor	ADRB2	0.0152
632	Alpha-1B adrenergic receptor	ADRA1B	0.015
492	Histamine H1 receptor	HRH1	0.0144
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0142
713	Sodium-dependent dopamine transporter	SLC6A3	0.0133
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0133
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0131
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.013
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0129
6143	Solute carrier family 22 member 7	SLC22A7	0.0128
5718	Cytochrome P450 2A6	CYP2A6	0.0124
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0121
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.011
318	Alpha-2A adrenergic receptor	ADRA2A	0.0107
136	Estrogen receptor	ESR1	0.0106
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0104
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0103
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0103
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0102
378	Alpha-2C adrenergic receptor	ADRA2C	0.0101
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0101
1898	Cytochrome P450 1B1	CYP1B1	0.0099
871	Glucocorticoid receptor	NR3C1	0.0099
629	Alpha-2B adrenergic receptor	ADRA2B	0.0098
789	Alpha-1D adrenergic receptor	ADRA1D	0.0098
124	Histamine H2 receptor	HRH2	0.0097
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
731	HIV-1 protease	HIV-1 protease	0.0097
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0095
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0091
672	Prostaglandin F2-alpha receptor	PTGFR	0.009
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0088
3939	Amine oxidase [flavin-containing] B	MAOB	0.0088
6148	Multidrug resistance-associated protein 7	ABCC10	0.0086
6106	Cytochrome P450 2C18	CYP2C18	0.0086
319	Opioid receptor, sigma 1	OPRS1	0.0084
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0083
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0081
2164	Multidrug resistance-associated protein 4	ABCC4	0.0081
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0081
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.008
6141	Sodium/bile acid cotransporter	SLC10A1	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0076
756	Sex hormone-binding globulin	SHBG	0.0075
338	DNA polymerase	UL30	0.0073
379	DNA polymerase	UL54	0.0073
697	DNA polymerase	ORF28	0.0073
2482	DNA polymerase	43	0.0073
4104	DNA polymerase	BALF5	0.0073
3941	Amine oxidase [flavin-containing] A	MAOA	0.0073
869	Estrogen receptor beta	ESR2	0.0073
6010	Thiamine transporter 1	SLC19A2	0.0073
3811	Cytochrome P450 19A1	CYP19A1	0.0073
20	Prostaglandin G/H synthase 1	PTGS1	0.0072
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0071
1024	Solute carrier family 22 member 11	SLC22A11	0.007
4773	Deoxycytidine kinase	DCK	0.0069
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0068
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
465	Calmodulin	CALM1	0.0067
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0066
175	Thiamin pyrophosphokinase 1	TPK1	0.0066
847	Mu-type opioid receptor	OPRM1	0.0065
817	DNA topoisomerase 2-alpha	TOP2A	0.0065
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
244	Angiotensin-converting enzyme	ACE	0.0063
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0063
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0062
467	Delta-type opioid receptor	OPRD1	0.0062
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0062
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0062
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0062
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0059
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0059
696	Kappa-type opioid receptor	OPRK1	0.0058
6171	Solute carrier family 28 member 3	SLC28A3	0.0058
1192	Sulfotransferase 1A1	SULT1A1	0.0055
174	Sigma 1-type opioid receptor	SIGMAR1	0.0054
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0053
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0053
4604	Liver carboxylesterase 1	CES1	0.0053
6137	Multidrug resistance-associated protein 6	ABCC6	0.0053
638	D(3) dopamine receptor	DRD3	0.0053
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0053
6182	Cytochrome P450 2J2	CYP2J2	0.0052
694	Matrix protein 2	M	0.0051
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0051
738	Monocarboxylate transporter 1	SLC16A1	0.0051
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0051
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0051
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0051
614	Progesterone receptor	PGR	0.005
844	Epidermal growth factor receptor	EGFR	0.005
885	5-hydroxytryptamine 1B receptor	HTR1B	0.005
6014	Cytochrome P450 2A13	CYP2A13	0.005
725	5-hydroxytryptamine 1D receptor	HTR1D	0.005
1353	DNA topoisomerase 1	TOP1	0.005
3552	DNA topoisomerase 1	topA	0.005
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0049
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0048
504	Mast/stem cell growth factor receptor	KIT	0.0047
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
6136	Multidrug resistance-associated protein 5	ABCC5	0.0046
303	Diamine acetyltransferase 2	SAT2	0.0045
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0045
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
131	Synaptic vesicular amine transporter	SLC18A2	0.0044
3947	Xanthine dehydrogenase/oxidase	XDH	0.0044
4120	NADPH--cytochrome P450 reductase	POR	0.0043
290	Prostaglandin G/H synthase 2	PTGS2	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
260	Cytochrome P450 51	ERG11	0.0043
761	Cytochrome P450 51	ERG11	0.0043
3163	Cytochrome P450 51	cyp51	0.0043
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0042
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0041
6070	Nischarin	NISCH	0.0041
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.004
123	Diamine acetyltransferase 1	SAT1	0.004
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.004
380	Cytochrome P450 17A1	CYP17A1	0.004
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.004
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.004
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0039
3611	Cytidine deaminase	cdd	0.0039
3707	Cytidine deaminase	cdd	0.0039
4211	Cytidine deaminase	CDA	0.0039
161	Tubulin beta chain	TUBB	0.0039
312	Tubulin beta chain	TUB2	0.0039
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0039
2472	Voltage-gated potassium channel	kcsA	0.0038
6366	Voltage-gated potassium channel	kcsA	0.0038
737	Mineralocorticoid receptor	NR3C2	0.0038
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0037
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0037
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0037
952	Dipeptidyl peptidase 4	DPP4	0.0037
122	P2Y purinoceptor 12	P2RY12	0.0036
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0035
477	DNA topoisomerase 4 subunit A	parC	0.0035
886	DNA topoisomerase 4 subunit A	parC	0.0035
6226	DNA topoisomerase 4 subunit A	parC	0.0035
1830	5'-nucleotidase	NT5E	0.0035
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0035
6167	Organic solute transporter subunit beta	OSTB	0.0035
6166	Organic solute transporter subunit alpha	OSTA	0.0035
2449	Tubulin alpha-3 chain	TUBA1A	0.0035
404	DNA gyrase subunit A	gyrA	0.0035
6224	DNA gyrase subunit A	gyrA	0.0035
432	D(4) dopamine receptor	DRD4	0.0034
125	DNA polymerase beta	POLB	0.0034
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0034
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0034
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0033
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
702	UMP-CMP kinase	CMPK1	0.0032
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
6432	Transporter	snf	0.0032
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0032
146	Androgen receptor	AR	0.0032
828	Phenylalanine-4-hydroxylase	PAH	0.0032
3109	Phenylalanine-4-hydroxylase	phhA	0.0032
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
4203	Histamine N-methyltransferase	HNMT	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
2499	Tubulin beta-2C chain	TUBB2C	0.0031
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0031
163	D(1B) dopamine receptor	DRD5	0.0031
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0031
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.003
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.003
1517	Beta-3 adrenergic receptor	ADRB3	0.003
26	Vascular endothelial growth factor receptor 3	FLT4	0.0029
5126	Arginase	rocF	0.0029
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
164	Histamine H4 receptor	HRH4	0.0029
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0029
683	Potassium transporter	GK0582	0.0029
70	Type-1 angiotensin II receptor	AGTR1	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0028
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0028
32	Vascular endothelial growth factor receptor 1	FLT1	0.0028
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0028
1341	Histamine H3 receptor	HRH3	0.0028
2300	Lysozyme	E	0.0028
3633	Lysozyme	R	0.0028
5597	Lysozyme	17	0.0028
6138	Multidrug resistance protein 3	ABCB4	0.0028
6085	Fatty acid-binding protein, intestinal	FABP2	0.0028
976	Platelet glycoprotein IX	GP9	0.0027
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0027
777	Tumor necrosis factor	TNF	0.0027
4237	50S ribosomal protein L22	rplV	0.0027
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0027
6111	DNA polymerase epsilon subunit 4	POLE4	0.0027
6112	DNA polymerase epsilon subunit 3	POLE3	0.0027
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0026
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0026
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0026
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0026
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0026
6110	DNA polymerase epsilon subunit 2	POLE2	0.0026
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0026
818	50S ribosomal protein L10	rplJ	0.0026
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0026
407	Vascular endothelial growth factor receptor 2	KDR	0.0026
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0026
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0026
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0026
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0026
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
1852	Microtubule-associated protein 2	MAP2	0.0026
6149	Solute carrier family 22 member 10	SLC22A10	0.0026
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0026
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0026
904	Glutathione S-transferase P	GSTP1	0.0026
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0025
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0025
29	Tubulin beta-1 chain	TUBB1	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0025
185	Vasopressin V1a receptor	AVPR1A	0.0024
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0024
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0024
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0024
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0024
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0024
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0024
322	Vasopressin V2 receptor	AVPR2	0.0024
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0024
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0024
6031	Cytochrome P450 3A43	CYP3A43	0.0024
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0024
4103	Proteasome subunit beta type 2	PSMB2	0.0023
4102	Proteasome subunit beta type 5	PSMB5	0.0023
4101	Proteasome subunit beta type 1	PSMB1	0.0023
1618	High affinity nerve growth factor receptor	NTRK1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0023
5816	Cadherin-5	CDH5	0.0023
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0023
5626	Nucleoside diphosphate kinase B	NME2	0.0023
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0023
373	Transthyretin	TTR	0.0023
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0022
908	Glutathione S-transferase theta-1	GSTT1	0.0022
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0022
716	5-hydroxytryptamine 7 receptor	HTR7	0.0021
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0021
468	Cytochrome P450 4A11	CYP4A11	0.0021
24	Thymidylate synthase	TMP1	0.0021
359	Thymidylate synthase	TYMS	0.0021
2626	Thymidylate synthase	thyA	0.0021
2729	Thymidylate synthase	thyA	0.0021
5352	Thymidylate synthase	THYA	0.0021
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0021
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.002
1864	RET proto-oncogene	RET	0.002
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.002
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.002
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.002
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.002
603	DNA polymerase alpha catalytic subunit	POLA1	0.002
1656	CYP2B protein	CYP2B	0.002
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.002
2107	Microtubule-associated protein 1A	MAP1A	0.002
3810	Catechol O-methyltransferase	COMT	0.002
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0019
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0019
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0019
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0019
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0019
6165	Copper-transporting ATPase 1	ATP7A	0.0019
6163	Copper-transporting ATPase 2	ATP7B	0.0019
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0019
3587	Gastrotropin	FABP6	0.0019
5294	Nucleoside diphosphate kinase A	NME1	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
239	Coagulation factor X	F10	0.0019
6146	High affinity copper uptake protein 1	SLC31A1	0.0019
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0018
6218	Pannexin-1	PANX1	0.0018
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0018
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0018
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0018
751	Potassium channel subfamily K member 6	KCNK6	0.0018
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0018
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0017
594	Thyroxine-binding globulin	SERPINA7	0.0017
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0017
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0017
768	FK506-binding protein 1A	FKBP1A	0.0017
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0017
5682	Ribonuclease pancreatic	RNASE1	0.0017
1074	Urokinase-type plasminogen activator	PLAU	0.0017
2539	Tubulin alpha-1 chain	TUBA4A	0.0016
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0016
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0016
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0016
1686	Choline transporter-like protein 1	SLC44A1	0.0016
3926	Choline transporter-like protein 2	SLC44A2	0.0016
861	Choline kinase alpha	CHKA	0.0016
3927	Choline transporter-like protein 3	SLC44A3	0.0016
769	High-affinity choline transporter 1	SLC5A7	0.0016
700	Choline dehydrogenase, mitochondrial	CHDH	0.0016
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0016
3925	Choline transporter-like protein 4	SLC44A4	0.0016
576	Choline O-acetyltransferase	CHAT	0.0016
3922	Phospholipase D2	PLD2	0.0016
3924	Phospholipase D1	PLD1	0.0016
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0016
172	Potassium channel subfamily K member 1	KCNK1	0.0016
6824	Tyrosine-protein kinase Lyn	LYN	0.0016
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
5300	Antigen peptide transporter 1	TAP1	0.0016
2599	Tyrosine-protein kinase HCK	HCK	0.0016
896	Glutathione S-transferase Mu 1	GSTM1	0.0016
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0016
758	Thyroid hormone receptor alpha	THRA	0.0016
489	Monocarboxylate transporter 2	SLC16A7	0.0016
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0015
277	Purine nucleoside phosphorylase	PNP	0.0015
2870	Purine nucleoside phosphorylase	punA	0.0015
2945	Purine nucleoside phosphorylase	punA	0.0015
4659	Purine nucleoside phosphorylase	TM_1596	0.0015
4825	Purine nucleoside phosphorylase	TTHA1435	0.0015
6755	Poliovirus receptor	PVR	0.0015
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0015
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0015
605	Fumarate reductase flavoprotein subunit	frdA	0.0015
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0015
3673	Fumarate reductase flavoprotein subunit	fccA	0.0015
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0015
6549	Fumarate reductase flavoprotein subunit	frdA	0.0015
165	FL cytokine receptor	FLT3	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1770	Phospholipase C	PLCL1	0.0015
2841	Phospholipase C	plc	0.0015
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0015
1178	Adenosine A2a receptor	ADORA2A	0.0014
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0014
153	Dopamine beta-hydroxylase	DBH	0.0014
1757	Myeloperoxidase	MPO	0.0014
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
346	Thyroid hormone receptor beta-1	THRB	0.0014
1629	Transcription factor AP-1	JUN	0.0014
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0014
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0014
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0014
273	Apoptosis regulator Bcl-2	BCL2	0.0013
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0013
1010	Cytochrome P450 51A1	CYP51A1	0.0013
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0013
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0013
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0013
365	Dihydrofolate reductase	DHFR	0.0013
2381	Dihydrofolate reductase	DFR1	0.0013
2833	Dihydrofolate reductase	Not Available	0.0013
2931	Dihydrofolate reductase	folA	0.0013
3544	Dihydrofolate reductase	folA	0.0013
3682	Dihydrofolate reductase	folA	0.0013
6642	Dihydrofolate reductase	folA	0.0013
6756	Dihydrofolate reductase	dfrA	0.0013
33	Cystine/glutamate transporter	SLC7A11	0.0013
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0012
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0012
3856	Fibroblast growth factor receptor 3	FGFR3	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0012
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0012
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0012
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0012
461	Glycine receptor subunit alpha-3	GLRA3	0.0012
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0012
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0012
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0012
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0012
6859	Protein S100-A4	S100A4	0.0012
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0011
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
2112	Toll-like receptor 9	TLR9	0.0011
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0011
469	Annexin A1	ANXA1	0.0011
5923	Microtubule-associated protein tau	MAPT	0.0011
5924	Microtubule-associated protein 4	MAP4	0.0011
6459	Glycodelin	PAEP	0.0011
232	Corticosteroid-binding globulin	SERPINA6	0.0011
427	Substance-P receptor	TACR1	0.0011
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0011
144	Hemoglobin subunit alpha	HBA1	0.001
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.001
106	Cannabinoid receptor 2	CNR2	0.001
6174	50S ribosomal protein L32	rpmF	0.001
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
811	Translocator protein	TSPO	0.001
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.001
890	Niemann-Pick C1-like protein 1	NPC1L1	0.001
68	Cannabinoid receptor 1	CNR1	0.001
199	Monocarboxylate transporter 8	SLC16A2	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
4192	DNA topoisomerase 2-beta	TOP2B	0.001
3957	Adenosine deaminase	ADA	0.0009
936	Ephrin type-A receptor 2	EPHA2	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0009
1291	cAMP response element-binding protein	CREB1	0.0009
1525	Heparin-binding growth factor 2	FGF2	0.0009
3809	Estrogen-related receptor gamma	ESRRG	0.0009
1569	G1/S-specific cyclin-D1	CCND1	0.0009
2240	Cell division protein kinase 2	CDK2	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
4210	Toll-like receptor 4	TLR4	0.0009
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0009
1760	Aminopeptidase N	ANPEP	0.0009
6843	Aminopeptidase N	pepN	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0009
54	Prothrombin	F2	0.0009
3932	Glutathione S-transferase A2	GSTA2	0.0009
1262	Corticotropin-lipotropin	POMC	0.0009
117	Sterol O-acyltransferase 1	SOAT1	0.0008
5787	Angiopoietin-1 receptor	TEK	0.0008
823	Fibroblast growth factor receptor 2	FGFR2	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
6211	Tubulin epsilon chain	TUBE1	0.0008
6212	Tubulin gamma-1 chain	TUBG1	0.0008
6210	Tubulin delta chain	TUBD1	0.0008
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
484	Tyrosine-protein kinase ABL2	ABL2	0.0008
780	Retinoic acid receptor RXR-gamma	RXRG	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1714	Mitogen-activated protein kinase 3	MAPK3	0.0008
459	Retinoic acid receptor RXR-alpha	RXRA	0.0007
88	Retinoic acid receptor RXR-beta	RXRB	0.0007
162	Retinoic acid receptor gamma-1	RARG	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0007
7	Nitric oxide synthase, inducible	NOS2	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6151	Monocarboxylate transporter 10	SLC16A10	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
1630	Integrin beta-2	ITGB2	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1374	Natriuretic peptides B	NPPB	0.0006
1827	Gap junction alpha-1 protein	GJA1	0.0006
1908	Vascular cell adhesion protein 1	VCAM1	0.0006
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0006
2216	Fibroblast growth factor receptor 4	FGFR4	0.0006
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0006
4217	Telomerase reverse transcriptase	TERT	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
814	Ryanodine receptor 1	RYR1	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
1176	Mitogen-activated protein kinase 1	MAPK1	0.0006
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0006
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0006
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
6048	Troponin C, skeletal muscle	TNNC2	0.0006
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0006
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0006
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0005
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
6044	Serum paraoxonase/lactonase 3	PON3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0005
2021	Thrombomodulin	THBD	0.0005
2207	Rhodopsin	RHO	0.0005
5798	Mitogen-activated protein kinase 11	MAPK11	0.0005
572	Integrin alpha-L	ITGAL	0.0005
183	Vascular endothelial growth factor A	VEGFA	0.0005
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0005
16	Adenosine A1 receptor	ADORA1	0.0005
2320	Thymidine kinase, cytosolic	TK1	0.0005
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0005
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0005
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0005
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
233	Potassium channel subfamily K member 2	KCNK2	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
1275	Estrogen sulfotransferase	SULT1E1	0.0005
4122	Histone deacetylase 2	HDAC2	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
1050	Bile salt sulfotransferase	SULT2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
3221	Cytochrome c4	cc4	0.0005
291	Nitric-oxide synthase, endothelial	NOS3	0.0004
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0004
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0004
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0004
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0004
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0004
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0004
6102	Arylamine N-acetyltransferase 2	NAT2	0.0004
5934	Cytochrome P450 26A1	CYP26A1	0.0004
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
4311	tRNA	TRDMT1	0.0004
4325	tRNA	trmD	0.0004
4328	tRNA	trmD	0.0004
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0004
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0004
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
6220	Aryl hydrocarbon receptor	AHR	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0004
84	Nuclear receptor 0B1	NR0B1	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0004
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0004
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0004
6168	Solute carrier family 22 member 16	SLC22A16	0.0004
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
6043	Putative G-protein coupled receptor 44	GPR44	0.0004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0004
444	Alcohol dehydrogenase 1B	ADH1B	0.0003
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
284	DNA-directed RNA polymerase beta chain	rpoB	0.0003
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0003
295	Carbonic anhydrase 1	CA1	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
1650	Heme carrier protein 1	SLC46A1	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
275	Arachidonate 5-lipoxygenase	ALOX5	0.0003
76	Nitric-oxide synthase, brain	NOS1	0.0002
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0002
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002
6020	Aldehyde oxidase	AOX1	0.0002
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0002
517	Alcohol dehydrogenase 1C	ADH1C	0.0002
921	Glutamate receptor 2	GRIA2	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01339 - Vecuronium

Targets

Transporters

Predictions