DT-Web

DB00781 - Polymyxin B Sulfate


Identification
Name Polymyxin B Sulfate
Accession Number DB00781 (APRD01190)
Type small molecule
Description Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 1203.4767
Groups approved
Monoisotopic Weight 1202.749927302
Pharmacology
Indication For treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
Mechanism of action Polymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate interacts with the lipopolysaccharide of the cytoplasmic outer membrane of Gram-negative bacteria, altering membrane permeability and causing cell death. It does not need to enter the cell.
Absorption Not absorbed from the normal alimentary tract.
Protein binding Not Available
Biotransformation Not Available
Route of elimination The drug is excreted slowly by the kidneys.
Toxicity Overdose can cause stomach pains, vomiting, and diarrhea.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Vecuronium Polymyxin B may increase the neuromuscular blocking action of Vecuronium. Risk of respiratory depression and apnea. Consider alternate therapy or monitor for prolonged neuromuscular blocking effects, such as respiratory paralysis.
Food Interactions Not Available

Targets


bacterial outer membrane
Name bacterial outer membrane
Gene Name Not Available
Pharmacological action yes
Actions incorporation into and destabilization
References
  • Yuan Z, Tam VH: Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms. Expert Opin Investig Drugs. 2008 May;17(5):661-8. - Pubmed
  • Zavascki AP, Goldani LZ, Li J, Nation RL: Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother. 2007 Dec;60(6):1206-15. Epub 2007 Sep 17. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
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