DT-Web

DB00958 - Carboplatin


Identification
Name Carboplatin
Accession Number DB00958 (APRD00466)
Type small molecule
Description An organoplatinum compound that possesses antineoplastic activity. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 371.254
Groups approved
Monoisotopic Weight 371.044481331
Pharmacology
Indication For the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide. It is also indicated for the palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy, including patients who have been previously treated with cisplatin.
Mechanism of action Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
Absorption The Cmax values and areas under the plasma concentration versus time curves from 0 to infinity (AUC inf) increase linearly with dose, although the increase was slightly more than dose proportional. Carboplatin exhibits linear pharmacokinetics.
Protein binding Carboplatin is not bound to plasma protein. However, the platinum itself from carboplatin irreversibly binds to plasma proteins and is slowly eliminated with a minimum half-life of 5 days.
Biotransformation Not Available
Route of elimination The major route of elimination of carboplatin is renal excretion. After 24 hours, all of the platinum is recovered in the urine as carboplatin. Whether biliary excretion occurs is not known.
Toxicity Toxic by ingestion. May be create toxic effect through inhalation or skin contact. May cause reproductive defects. May act as a sensitizer. ORL-RAT LD50 343 mg kg-1; SCN-RAT LD50 72 mg kg-1; IPN-MUS LD50 118 mg kg-1
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Bendamustine Increases toxicity through pharmacodynamic synergism. Additive myelosuppression.
Docetaxel Platinum derivatives such as carboplatin may enhance the myelosuppressive effect of taxane derivatives such as docetaxel. Administer taxane derivative before platinum derivative when given as sequential infusions to limit toxicity. Administering the taxane derivative before the platinum derivative seems prudent.
Fosphenytoin The antineoplasic agent decreases the effect of hydantoin
Leflunomide Immunosuppressants such as carboplatin may enhance the adverse/toxic effect of leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Consider eliminating the use of a leflunomide loading dose in patients who are receiving other immunosuppressants in order to reduce the risk for serious adverse events such as hematologic toxicity. Also, patients receiving both leflunomide and another immunosuppressive medication should be monitored for bone marrow suppression at least monthly throughout the duration of concurrent therapy.
Natalizumab Immunosuppressants such as natalizumab may enhance the adverse/toxic effect of natalizumab. Specifically, the risk of concurrent infection may be increased. Patients receiving natalizumab should not use concurrent immunosuppressants.
Paclitaxel Platinum derivatives such as carboplatin may enhance the myelosuppressive effect of taxane derivatives such as paclitaxel. Administer taxane derivative before platinum derivative when given as sequential infusions to limit toxicity. Administering the taxane derivative before the platinum derivative seems prudent.
Phenytoin The antineoplasic agent decreases the effect of hydantoin
Pimecrolimus Pimecrolimus may enhance the adverse/toxic effect of immunosuppressants such as carboplatin. Avoid use of pimecrolimus cream in patients receiving immunosuppressants.
Roflumilast Roflumilast may enhance the immunosuppressive effect of immunosuppressants such as carboplatin. he Canadian roflumilast product monograph recommends avoiding concurrent use of roflumilast with any immunosuppressant medications due to the antiinflammatory/immune altering effects of roflumilast and the lack of relevant clinical experience with such use. Of note, this recommendation to avoid concurrent use does not apply to either inhaled corticosteroids (which have much more limited systemic immune-suppressing actions) or short-term systemic corticosteroid use. U.S. prescribing information does not contain this warning; but it appears prudent to avoid this combination when possible.
Sorafenib Sorafenib may enhance the adverse/toxic effect of carboplatin. Concurrent use of sorafenib with carboplatin and placlitaxel in patients with squamous cell lung cancer is contraindicated. The use of this combination in other settings is not specifically contraindicated, but any such use should be approached with added caution.
Tacrolimus Tacrolimus (Topical) may enhance the adverse/toxic effect of immunosuppressants such as carboplatin. Avoid use of tacrolimus ointment in patients receiving immunosuppressants.
Topotecan Administration of Topotecan after Carboplatin therapy may increase the risk of hematologic toxicity, such as neutropenia and/or thrombocytopenia. A dose adjustment may be required or the sequence of administration reversed.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Food Interactions
  • Avoid echinacea as it may decrease effectiveness of immunosuppresants like carboplatin

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions cross-linking/alkylation
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Sharma S, Gong P, Temple B, Bhattacharyya D, Dokholyan NV, Chaney SG: Molecular Dynamic Simulations of Cisplatin- and Oxaliplatin-d(GG) Intrastand Cross-links Reveal Differences in their Conformational Dynamics. J Mol Biol. 2007 Aug 23;. - Pubmed
  • Appleton K, Mackay HJ, Judson I, Plumb JA, McCormick C, Strathdee G, Lee C, Barrett S, Reade S, Jadayel D, Tang A, Bellenger K, Mackay L, Setanoians A, Schatzlein A, Twelves C, Kaye SB, Brown R: Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors. J Clin Oncol. 2007 Oct 10;25(29):4603-9. - Pubmed
DTHybrid score Not Available

Enzymes


Xanthine dehydrogenase/oxidase
Name Xanthine dehydrogenase/oxidase
Gene Name XDH
Actions inducer
References
  • Husai K, Jagannathan R, Hasan Z, Trammell GL, Rybak LP, Hazelrigg SR, Somani SM: Dose response of carboplatin-induced nephrotoxicity in rats. Pharmacol Toxicol. 2002 Aug;91(2):83-9. - Pubmed
  • Husain K, Whitworth C, Rybak LP: Time response of carboplatin-induced nephrotoxicity in rats. Pharmacol Res. 2004 Sep;50(3):291-300. - Pubmed
  • Husain K, Whitworth C, Somani SM, Rybak LP: Carboplatin-induced oxidative stress in rat cochlea. Hear Res. 2001 Sep;159(1-2):14-22. - Pubmed
  • Husain K, Whitworth C, Hazelrigg S, Rybak L: Carboplatin-induced oxidative injury in rat inferior colliculus. Int J Toxicol. 2003 Sep-Oct;22(5):335-42. - Pubmed
DTHybrid score 0.6182
Myeloperoxidase
Name Myeloperoxidase
Gene Name MPO
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.5782
Glutathione S-transferase theta-1
Name Glutathione S-transferase theta-1
Gene Name GSTT1
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.4298
Metallothionein-1A
Name Metallothionein-1A
Gene Name Not Available
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score Not Available
Metallothionein-2
Name Metallothionein-2
Gene Name Not Available
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score Not Available
Superoxide dismutase [Cu-Zn]
Name Superoxide dismutase [Cu-Zn]
Gene Name SOD1
Actions Not Available
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.4656
Glutathione S-transferase P
Name Glutathione S-transferase P
Gene Name GSTP1
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.9241
Glutathione S-transferase Mu 1
Name Glutathione S-transferase Mu 1
Gene Name GSTM1
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.9147
NAD(P)H dehydrogenase [quinone] 1
Name NAD(P)H dehydrogenase [quinone] 1
Gene Name NQO1
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 1.0638

Transporters


High affinity copper uptake protein 1
Name High affinity copper uptake protein 1
Gene Name SLC31A1
Actions substrate
References
  • Howell SB, Safaei R, Larson CA, Sailor MJ: Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs. Mol Pharmacol. 2010 Jun;77(6):887-94. Epub 2010 Feb 16. - Pubmed
  • Song IS, Savaraj N, Siddik ZH, Liu P, Wei Y, Wu CJ, Kuo MT: Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. Mol Cancer Ther. 2004 Dec;3(12):1543-9. - Pubmed
DTHybrid score 0.4519
Probable low affinity copper uptake protein 2
Name Probable low affinity copper uptake protein 2
Gene Name SLC31A2
Actions substrate
References
  • Blair BG, Larson CA, Safaei R, Howell SB: Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin. Clin Cancer Res. 2009 Jul 1;15(13):4312-21. Epub 2009 Jun 9. - Pubmed
DTHybrid score 0.3831
Copper-transporting ATPase 1
Name Copper-transporting ATPase 1
Gene Name ATP7A
Actions substrate
References
  • Samimi G, Katano K, Holzer AK, Safaei R, Howell SB: Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B. Mol Pharmacol. 2004 Jul;66(1):25-32. - Pubmed
DTHybrid score 0.4702
Copper-transporting ATPase 2
Name Copper-transporting ATPase 2
Gene Name ATP7B
Actions substrate
References
  • Samimi G, Katano K, Holzer AK, Safaei R, Howell SB: Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B. Mol Pharmacol. 2004 Jul;66(1):25-32. - Pubmed
DTHybrid score 0.4703
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Ceckova M, Vackova Z, Radilova H, Libra A, Buncek M, Staud F: Effect of ABCG2 on cytotoxicity of platinum drugs: interference of EGFP. Toxicol In Vitro. 2008 Dec;22(8):1846-52. doi: 10.1016/j.tiv.2008.09.001. Epub 2008 Sep 9. - Pubmed
DTHybrid score 0.3932
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.392

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.1622
6144 Solute carrier family 22 member 2 SLC22A2 0.1318
4200 Cytochrome P450 1A2 CYP1A2 0.1277
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.124
6137 Multidrug resistance-associated protein 6 ABCC6 0.121
4757 Cytochrome P450 2C9 CYP2C9 0.1204
290 Prostaglandin G/H synthase 2 PTGS2 0.1193
4031 Glutathione S-transferase A1 GSTA1 0.1165
1898 Cytochrome P450 1B1 CYP1B1 0.1162
4512 Cytochrome P450 3A4 CYP3A4 0.1135
6024 Cytochrome P450 1A1 CYP1A1 0.0955
2165 Glutathione S-transferase Mu 2 GSTM2 0.0952
6136 Multidrug resistance-associated protein 5 ABCC5 0.0943
468 Cytochrome P450 4A11 CYP4A11 0.0892
6013 Cytochrome P450 2E1 CYP2E1 0.0892
3932 Glutathione S-transferase A2 GSTA2 0.0835
6030 Cytochrome P450 2B6 CYP2B6 0.0792
862 Multidrug resistance-associated protein 1 ABCC1 0.0747
6145 Solute carrier family 22 member 1 SLC22A1 0.0745
6147 Solute carrier family 22 member 3 SLC22A3 0.0745
3923 Cholinesterase BCHE 0.0675
4924 Cytochrome P450 2C8 CYP2C8 0.0645
2314 Triosephosphate isomerase TPI 0.0595
3417 Triosephosphate isomerase tpiA 0.0595
3443 Triosephosphate isomerase tpiA 0.0595
6346 Triosephosphate isomerase TPI1 0.0595
6020 Aldehyde oxidase AOX1 0.0573
20 Prostaglandin G/H synthase 1 PTGS1 0.0572
6016 Cytochrome P450 2C19 CYP2C19 0.0562
4118 Cytochrome P450 3A5 CYP3A5 0.0554
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0544
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0526
4041 Microsomal glutathione S-transferase 2 MGST2 0.0505
901 Glutathione S-transferase Mu 4 GSTM4 0.0505
4119 Cytochrome P450 2D6 CYP2D6 0.048
275 Arachidonate 5-lipoxygenase ALOX5 0.0457
5241 Probable thiol peroxidase tpx 0.0454
5239 Exopolyphosphatase ppx 0.0453
4440 NADH peroxidase npr 0.0451
4407 FMN-dependent NADH-azoreductase azoR 0.045
5169 FMN-dependent NADH-azoreductase azoR 0.045
776 Bile salt export pump ABCB11 0.0409
6148 Multidrug resistance-associated protein 7 ABCC10 0.0405
2164 Multidrug resistance-associated protein 4 ABCC4 0.0395
2750 Aspartate 1-decarboxylase panD 0.0394
817 DNA topoisomerase 2-alpha TOP2A 0.0378
6142 Solute carrier family 22 member 8 SLC22A8 0.0374
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0364
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.036
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.036
899 Glutathione S-transferase Mu 3 GSTM3 0.0359
905 Glutathione transferase omega-1 GSTO1 0.0356
1405 Thiopurine S-methyltransferase TPMT 0.0353
3759 Glutathione S-transferase gst 0.0325
4541 Glutathione S-transferase GST 0.0325
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0316
6107 Cytochrome P450 3A7 CYP3A7 0.0314
1736 Somatostatin SST 0.0311
4186 Neuropeptide Y receptor type 2 NPY2R 0.0311
3873 Prolyl endopeptidase PREP 0.031
6928 Prolyl endopeptidase Not Available 0.031
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0303
2159 Quinone oxidoreductase CRYZ 0.0297
118 Organic cation/carnitine transporter 2 SLC22A5 0.0288
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0285
86 SEC14-like protein 4 SEC14L4 0.0284
375 SEC14-like protein 3 SEC14L3 0.0284
4076 Diacylglycerol kinase alpha DGKA 0.0284
723 Cytosolic phospholipase A2 PLA2G4A 0.0284
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0284
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0283
1729 Solute carrier family 22 member 6 SLC22A6 0.028
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0278
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0277
1313 Lactoylglutathione lyase GLO1 0.0265
587 Serum albumin ALB 0.0264
283 SEC14-like protein 2 SEC14L2 0.0261
708 Alpha-tocopherol transfer protein TTPA 0.0261
54 Prothrombin F2 0.0257
309 Antithrombin-III SERPINC1 0.0251
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0246
997 Protein kinase C beta type PRKCB 0.0245
4192 DNA topoisomerase 2-beta TOP2B 0.0245
239 Coagulation factor X F10 0.0244
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0241
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0239
563 Thyroid peroxidase TPO 0.0238
153 Dopamine beta-hydroxylase DBH 0.0238
6143 Solute carrier family 22 member 7 SLC22A7 0.0224
1970 Protein kinase C alpha type PRKCA 0.0223
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0221
503 Somatostatin receptor type 1 SSTR1 0.0214
3866 Serum amyloid A protein SAA1 0.0209
1932 Apolipoprotein E APOE 0.0208
1200 AMBP protein AMBP 0.0208
810 Heme oxygenase 1 HMOX1 0.0205
3391 Heme oxygenase 1 pbsA1 0.0205
2443 Azurin azu 0.0205
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0203
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
6168 Solute carrier family 22 member 16 SLC22A16 0.0201
3872 Somatostatin receptor type 5 SSTR5 0.02
6008 Somatostatin receptor type 2 SSTR2 0.02
4103 Proteasome subunit beta type 2 PSMB2 0.02
4101 Proteasome subunit beta type 1 PSMB1 0.0199
4102 Proteasome subunit beta type 5 PSMB5 0.0199
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0195
70 Type-1 angiotensin II receptor AGTR1 0.019
856 Vitamin D3 receptor VDR 0.0189
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0186
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0183
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.018
833 Organic cation/carnitine transporter 1 SLC22A4 0.0179
4120 NADPH--cytochrome P450 reductase POR 0.0178
327 Glutathione reductase gor 0.0171
5110 Glutathione reductase GR2 0.0171
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0171
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.017
63 Malate dehydrogenase mdh 0.0165
2329 Malate dehydrogenase mdh 0.0165
3445 Malate dehydrogenase mdh 0.0165
4420 Malate dehydrogenase mdh 0.0165
4438 Malate dehydrogenase mdh 0.0165
3811 Cytochrome P450 19A1 CYP19A1 0.0165
115 Penicillin-binding protein 2 mrdA 0.016
6069 Penicillin-binding protein 2 mrdA 0.016
6118 Penicillin-binding protein 2 penA 0.016
6187 Penicillin-binding protein 2 pbpA 0.016
6686 Penicillin-binding protein 2 pbp2 0.016
6939 Penicillin-binding protein 2 mrdA 0.016
7163 Penicillin-binding protein 2 pbpA 0.016
867 Penicillin-binding protein 3 pbpC 0.016
6119 Penicillin-binding protein 3 pbp3 0.016
7154 Penicillin-binding protein 3 pbp3 0.016
7157 Penicillin-binding protein 3 LMHCC_2184 0.016
7162 Penicillin-binding protein 3 pbpB 0.016
7172 Penicillin-binding protein 3 pbp3 0.016
13 Aminomethyltransferase, mitochondrial AMT 0.0159
136 Estrogen receptor ESR1 0.0158
6012 Tryptophan 2,3-dioxygenase TDO2 0.0155
5898 Complement C3 C3 0.0154
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0154
6141 Sodium/bile acid cotransporter SLC10A1 0.0152
3823 Cytokine receptor common gamma chain IL2RG 0.0151
893 [Citrate [pro-3S]-lyase] ligase citC 0.0149
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0149
1353 DNA topoisomerase 1 TOP1 0.0149
3552 DNA topoisomerase 1 topA 0.0149
4035 Glutathione S-transferase Mu 5 GSTM5 0.0147
4604 Liver carboxylesterase 1 CES1 0.0142
1928 Leukotriene C4 synthase LTC4S 0.014
900 Glutathione S-transferase A4 GSTA4 0.014
4043 Glutaredoxin-2, mitochondrial GLRX2 0.014
4037 Hypothetical protein GPX1 0.014
4297 Hypothetical protein SP_1951 0.014
4521 Hypothetical protein BC_2969 0.014
4540 Hypothetical protein TM_1070 0.014
4555 Hypothetical protein MT1739 0.014
4569 Hypothetical protein mshD 0.014
4578 Hypothetical protein PA3270 0.014
4747 Hypothetical protein PA3967 0.014
5177 Hypothetical protein TM_0096 0.014
5194 Hypothetical protein PA1204 0.014
5240 Hypothetical protein Rv2991 0.014
5370 Hypothetical protein TM_1158 0.014
5710 Hypothetical protein Tb927.5.1360 0.014
906 Glutathione peroxidase 1 GPX1 0.014
903 Glutathione S-transferase A5 GSTA5 0.014
4034 Glutaredoxin-1 GLRX 0.014
4029 Microsomal glutathione S-transferase 3 MGST3 0.014
4032 Microsomal glutathione S-transferase 1 MGST1 0.014
4042 Glutathione transferase omega-2 GSTO2 0.014
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.014
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.014
4036 Glutathione peroxidase 6 GPX6 0.014
4040 Glutathione peroxidase 7 GPX7 0.014
907 Glutathione peroxidase 2 GPX2 0.014
4038 Glutathione peroxidase 4 GPX4 0.014
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.014
911 Glutathione peroxidase 3 GPX3 0.014
910 Epididymal secretory glutathione peroxidase GPX5 0.014
4033 S-formylglutathione hydrolase ESD 0.014
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.014
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0139
5718 Cytochrome P450 2A6 CYP2A6 0.0138
844 Epidermal growth factor receptor EGFR 0.0134
633 Penicillin-binding proteins 1A/1B pbpA 0.0132
724 Interleukin-2 receptor alpha chain IL2RA 0.0131
717 Interleukin-2 receptor subunit beta IL2RB 0.0131
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0131
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0131
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.013
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.013
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0128
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0127
897 Glutathione S-transferase kappa 1 GSTK1 0.0127
898 Glutathione S-transferase A3 GSTA3 0.0126
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0126
3319 Hydroxyacylglutathione hydrolase HAGH 0.0126
504 Mast/stem cell growth factor receptor KIT 0.0123
909 Maleylacetoacetate isomerase GSTZ1 0.0123
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0122
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
6677 Myelin P2 protein PMP2 0.0122
400 Coagulation factor IX F9 0.0118
5461 Coagulation factor IX F9 0.0118
3917 Methylenetetrahydrofolate reductase MTHFR 0.0118
1024 Solute carrier family 22 member 11 SLC22A11 0.0118
3941 Amine oxidase [flavin-containing] A MAOA 0.0117
2517 Subtilisin BPN' apr 0.0116
117 Sterol O-acyltransferase 1 SOAT1 0.0115
33 Cystine/glutamate transporter SLC7A11 0.0114
477 DNA topoisomerase 4 subunit A parC 0.0113
886 DNA topoisomerase 4 subunit A parC 0.0113
6226 DNA topoisomerase 4 subunit A parC 0.0113
404 DNA gyrase subunit A gyrA 0.0111
6224 DNA gyrase subunit A gyrA 0.0111
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0111
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0111
551 Carnitine O-acetyltransferase CRAT 0.011
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.011
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.011
604 Vitamin K-dependent protein Z PROZ 0.011
303 Diamine acetyltransferase 2 SAT2 0.0109
623 Spermine oxidase SMOX 0.0109
1317 Spermine synthase SMS 0.0109
1656 CYP2B protein CYP2B 0.0108
714 Glutathione reductase, mitochondrial GSR 0.0108
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0107
2596 Acetyl-CoA acetyltransferase phbA 0.0105
207 Glutathione synthetase GSS 0.0104
5269 Glutathione synthetase gshB 0.0104
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0103
123 Diamine acetyltransferase 1 SAT1 0.01
1245 Vitamin K-dependent protein S PROS1 0.0099
422 Vitamin K-dependent protein C PROC 0.0099
228 Beta platelet-derived growth factor receptor PDGFRB 0.0097
713 Sodium-dependent dopamine transporter SLC6A3 0.0096
3939 Amine oxidase [flavin-containing] B MAOB 0.0094
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0094
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0094
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0093
6106 Cytochrome P450 2C18 CYP2C18 0.0093
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0092
6859 Protein S100-A4 S100A4 0.0091
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.009
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0089
798 Osteocalcin BGLAP 0.0088
4773 Deoxycytidine kinase DCK 0.0087
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0087
465 Calmodulin CALM1 0.0087
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0087
6599 HTH-type transcriptional regulator ttgR ttgR 0.0087
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0086
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0084
6171 Solute carrier family 28 member 3 SLC28A3 0.0084
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0084
26 Vascular endothelial growth factor receptor 3 FLT4 0.0083
1650 Heme carrier protein 1 SLC46A1 0.0083
738 Monocarboxylate transporter 1 SLC16A1 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0081
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.008
32 Vascular endothelial growth factor receptor 1 FLT1 0.008
369 Coagulation factor VII F7 0.0079
76 Nitric-oxide synthase, brain NOS1 0.0079
449 Ornithine decarboxylase ODC1 0.0078
731 HIV-1 protease HIV-1 protease 0.0076
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0076
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0075
29 Tubulin beta-1 chain TUBB1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
407 Vascular endothelial growth factor receptor 2 KDR 0.0074
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0073
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0073
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0073
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0073
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0073
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0072
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0072
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0072
185 Vasopressin V1a receptor AVPR1A 0.0071
2417 Chloramphenicol acetyltransferase cat 0.0071
3278 Chloramphenicol acetyltransferase cat 0.0071
24 Thymidylate synthase TMP1 0.0071
359 Thymidylate synthase TYMS 0.0071
2626 Thymidylate synthase thyA 0.0071
2729 Thymidylate synthase thyA 0.0071
5352 Thymidylate synthase THYA 0.0071
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.007
7 Nitric oxide synthase, inducible NOS2 0.007
322 Vasopressin V2 receptor AVPR2 0.007
165 FL cytokine receptor FLT3 0.0069
556 Alpha-1A adrenergic receptor ADRA1A 0.0069
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0069
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0068
992 Protein tyrosine kinase 2 beta PTK2B 0.0067
461 Glycine receptor subunit alpha-3 GLRA3 0.0067
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0066
3601 Dihydropteroate synthase 1 folP1 0.0065
3807 Dihydropteroate synthase 1 folP1 0.0065
3808 Dihydropteroate synthase 2 folP2 0.0065
2539 Tubulin alpha-1 chain TUBA4A 0.0064
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0064
614 Progesterone receptor PGR 0.0064
183 Vascular endothelial growth factor A VEGFA 0.0063
5626 Nucleoside diphosphate kinase B NME2 0.0063
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0063
5923 Microtubule-associated protein tau MAPT 0.0063
5924 Microtubule-associated protein 4 MAP4 0.0063
3270 Elongation factor G fusA 0.0062
122 P2Y purinoceptor 12 P2RY12 0.0062
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0061
6432 Transporter snf 0.0061
2808 Chloramphenicol acetyltransferase 3 cat3 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.006
824 Sodium-dependent serotonin transporter SLC6A4 0.006
6036 Eosinophil peroxidase EPX 0.0059
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
1852 Microtubule-associated protein 2 MAP2 0.0058
3830 Calreticulin CALR 0.0057
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
291 Nitric-oxide synthase, endothelial NOS3 0.0055
273 Apoptosis regulator Bcl-2 BCL2 0.0055
3709 Glycerol uptake facilitator protein glpF 0.0055
3116 Bacterioferritin bfr 0.0055
4906 Bacterioferritin bfr 0.0055
4965 Bacterioferritin bfr 0.0055
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0055
3173 Enolase eno 0.0055
3393 TGF-beta receptor type-2 TGFBR2 0.0055
3238 Multidrug resistance protein mexA mexA 0.0055
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0055
6034 Hydroxyindole O-methyltransferase ASMT 0.0055
6035 Nuclear receptor ROR-beta RORB 0.0055
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0054
5294 Nucleoside diphosphate kinase A NME1 0.0052
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
1374 Natriuretic peptides B NPPB 0.0051
161 Tubulin beta chain TUBB 0.0051
312 Tubulin beta chain TUB2 0.0051
1827 Gap junction alpha-1 protein GJA1 0.0051
1908 Vascular cell adhesion protein 1 VCAM1 0.0051
6220 Aryl hydrocarbon receptor AHR 0.0051
5787 Angiopoietin-1 receptor TEK 0.0049
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0049
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0049
869 Estrogen receptor beta ESR2 0.0049
1760 Aminopeptidase N ANPEP 0.0049
6843 Aminopeptidase N pepN 0.0049
2852 DNA mismatch repair protein mutL mutL 0.0048
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0048
765 Indoleamine 2,3-dioxygenase IDO1 0.0047
6102 Arylamine N-acetyltransferase 2 NAT2 0.0045
362 Melatonin receptor type 1B MTNR1B 0.0045
571 Melatonin receptor type 1A MTNR1A 0.0045
6459 Glycodelin PAEP 0.0045
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0045
3191 Histidinol dehydrogenase hisD 0.0044
3221 Cytochrome c4 cc4 0.0044
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0044
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0044
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0043
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0043
436 5-hydroxytryptamine 2B receptor HTR2B 0.0042
293 Gamma-glutamyl hydrolase GGH 0.0041
1629 Transcription factor AP-1 JUN 0.0041
4311 tRNA TRDMT1 0.0041
4325 tRNA trmD 0.0041
4328 tRNA trmD 0.0041
4692 A/G-specific adenine glycosylase mutY 0.004
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.004
469 Annexin A1 ANXA1 0.004
831 D(2) dopamine receptor DRD2 0.0039
6167 Organic solute transporter subunit beta OSTB 0.0039
6166 Organic solute transporter subunit alpha OSTA 0.0039
2802 Endoglucanase G celCCG 0.0039
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0039
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0038
6316 ADP-ribosylation factor 1 ARF1 0.0038
6837 Serine/threonine-protein kinase 17B STK17B 0.0038
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0038
2232 Interleukin-5 IL5 0.0037
590 5-hydroxytryptamine 2C receptor HTR2C 0.0037
1593 Mucin-2 MUC2 0.0037
444 Alcohol dehydrogenase 1B ADH1B 0.0037
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0036
5448 Ribonuclease Z rnz 0.0035
5449 Hypothetical gliding protein mglB 0.0035
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0035
4705 Manganese catalase Not Available 0.0035
5439 33 kDa chaperonin hslO 0.0035
332 Beta-lactamase blaZ 0.0035
2478 Beta-lactamase ampC 0.0035
2613 Beta-lactamase ampC 0.0035
2635 Beta-lactamase ampC 0.0035
2700 Beta-lactamase penP 0.0035
5445 Beta-lactamase blaB 0.0035
6019 Beta-lactamase SHV-7 0.0035
6701 Beta-lactamase cphA 0.0035
5443 UPF0189 protein ymdB ymdB 0.0035
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0035
5440 UPF0067 protein yebR yebR 0.0035
2720 Copper-containing nitrite reductase nirK 0.0035
5454 Internalin-A inlA 0.0035
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0035
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0035
342 P protein [Includes: DNA-directed DNA polymerase P 0.0035
612 P protein [Includes: DNA-directed DNA polymerase P 0.0035
4498 Ornithine cyclodeaminase PP3533 0.0034
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0034
597 Dihydropteridine reductase QDPR 0.0034
3856 Fibroblast growth factor receptor 3 FGFR3 0.0033
502 5-hydroxytryptamine 2A receptor HTR2A 0.0033
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0033
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0033
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0032
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0032
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0032
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0032
5122 Mersacidin decarboxylase mrsD 0.0031
5078 Amine oxidase, flavin-containing PSPTO1126 0.0031
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0031
526 Thioredoxin reductase trxB 0.0031
3767 Thioredoxin reductase trxB 0.0031
3763 5,10-methylenetetrahydrofolate reductase metF 0.0031
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0031
5094 5,10-methylenetetrahydrofolate reductase metF 0.0031
5095 Putidaredoxin reductase camA 0.0031
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0031
5109 Outer membrane protein p64k or PM-6 m-6 0.0031
5115 FkbI fkbI 0.0031
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0031
5083 Cryptochrome DASH cry 0.0031
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0031
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0031
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0031
5081 L-aspartate oxidase nadB 0.0031
3133 UDP-galactopyranose mutase glf 0.0031
5099 UDP-galactopyranose mutase glf 0.0031
1410 Oxidoreductase HSD17B6 0.0031
4725 Oxidoreductase Not Available 0.0031
5124 Oxidoreductase Not Available 0.0031
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0031
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0031
5111 Phenylacetone monooxygenase pamO 0.0031
4486 Phenol 2-hydroxylase component B pheA2 0.0031
4477 Dihydrolipoyl dehydrogenase lpdV 0.0031
5077 Dihydrolipoyl dehydrogenase Not Available 0.0031
5117 Dihydrolipoyl dehydrogenase lpd 0.0031
4439 Ferredoxin reductase bphA4 0.0031
6149 Solute carrier family 22 member 10 SLC22A10 0.0031
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
5450 Prolyl endopeptidase Pep pep 0.0031
4771 Dissimilatory copper-containing nitrite reductase nir 0.0031
3356 Diaminopimelate decarboxylase lysA 0.0031
2714 Chorismate mutase aroH 0.0031
4611 Chorismate mutase aroG 0.0031
3274 Hydroxylamine reductase hcp 0.0031
4804 Hydroxylamine reductase hcp 0.0031
131 Synaptic vesicular amine transporter SLC18A2 0.0031
702 UMP-CMP kinase CMPK1 0.0031
6031 Cytochrome P450 3A43 CYP3A43 0.0031
489 Monocarboxylate transporter 2 SLC16A7 0.0031
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.003
3587 Gastrotropin FABP6 0.003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.003
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.003
737 Mineralocorticoid receptor NR3C2 0.003
146 Androgen receptor AR 0.003
756 Sex hormone-binding globulin SHBG 0.003
3810 Catechol O-methyltransferase COMT 0.003
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0029
3399 Limonene-1,2-epoxide hydrolase limA 0.0029
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0028
2599 Tyrosine-protein kinase HCK HCK 0.0028
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0028
777 Tumor necrosis factor TNF 0.0028
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0028
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0028
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0028
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0028
6085 Fatty acid-binding protein, intestinal FABP2 0.0028
3102 Flavohemoprotein hmp 0.0028
4969 Flavohemoprotein hmp 0.0028
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0027
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0027
5072 N,N-dimethylglycine oxidase dmg 0.0027
5073 Ferredoxin--NADP reductase petH 0.0027
5076 Ferredoxin--NADP reductase fpr 0.0027
5119 Ferredoxin--NADP reductase petH 0.0027
5121 Ferredoxin--NADP reductase fpr 0.0027
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0027
3594 Deoxyribodipyrimidine photo-lyase phr 0.0027
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0027
5080 Deoxyribodipyrimidine photo-lyase phr 0.0027
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0027
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0027
2526 NADPH-ferredoxin reductase fprA fprA 0.0027
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0027
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0027
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0027
2470 Pyruvate oxidase pox5 0.0027
2268 Cholesterol oxidase choB 0.0027
2822 Cholesterol oxidase choA 0.0027
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0027
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0027
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0027
106 Cannabinoid receptor 2 CNR2 0.0027
5180 L(+)-mandelate dehydrogenase mdlB 0.0027
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0027
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0027
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0027
3500 Putative family 31 glucosidase yicI yicI 0.0027
373 Transthyretin TTR 0.0027
4608 Putative cytochrome P450 SCO1207 0.0027
4963 Putative cytochrome P450 SCO2884 0.0027
6254 Putative cytochrome P450 SCO6998 0.0027
1569 G1/S-specific cyclin-D1 CCND1 0.0027
3480 Mannan endo-1,4-beta-mannosidase manA 0.0027
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0026
577 Argininosuccinate lyase ASL 0.0026
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0026
68 Cannabinoid receptor 1 CNR1 0.0026
1615 Chymase CMA1 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
936 Ephrin type-A receptor 2 EPHA2 0.0026
3959 Cell division protein kinase 4 CDK4 0.0025
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0025
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0025
511 5-hydroxytryptamine 1F receptor HTR1F 0.0025
2893 Glycine oxidase thiO 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
126 D-lactate dehydrogenase dld 0.0025
3545 D-lactate dehydrogenase Not Available 0.0025
4510 D-lactate dehydrogenase ldhA 0.0025
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0025
3809 Estrogen-related receptor gamma ESRRG 0.0025
605 Fumarate reductase flavoprotein subunit frdA 0.0024
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0024
3673 Fumarate reductase flavoprotein subunit fccA 0.0024
4912 Fumarate reductase flavoprotein subunit ifcA 0.0024
6549 Fumarate reductase flavoprotein subunit frdA 0.0024
193 Beta-1 adrenergic receptor ADRB1 0.0024
6211 Tubulin epsilon chain TUBE1 0.0024
6210 Tubulin delta chain TUBD1 0.0024
6212 Tubulin gamma-1 chain TUBG1 0.0024
871 Glucocorticoid receptor NR3C1 0.0024
2567 Thymidylate synthase thyX thyX 0.0024
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0024
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0024
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0024
2823 Trypanothione reductase TPR 0.0024
766 Beta-2 adrenergic receptor ADRB2 0.0024
3955 Cell division protein kinase 6 CDK6 0.0023
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0023
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0023
2769 P-hydroxybenzoate hydroxylase pobA 0.0023
2809 P-hydroxybenzoate hydroxylase pobA 0.0023
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0023
484 Tyrosine-protein kinase ABL2 ABL2 0.0022
823 Fibroblast growth factor receptor 2 FGFR2 0.0022
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0022
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
6182 Cytochrome P450 2J2 CYP2J2 0.0022
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
2380 Monomeric sarcosine oxidase soxA 0.0022
5818 Folate receptor alpha FOLR1 0.0022
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0021
84 Nuclear receptor 0B1 NR0B1 0.0021
1618 High affinity nerve growth factor receptor NTRK1 0.0021
380 Cytochrome P450 17A1 CYP17A1 0.0021
6645 D-amino-acid oxidase DAO 0.0021
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0021
1192 Sulfotransferase 1A1 SULT1A1 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
1630 Integrin beta-2 ITGB2 0.002
1058 Cell division protein kinase 5 CDK5 0.002
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0019
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0019
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0019
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0019
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0018
725 5-hydroxytryptamine 1D receptor HTR1D 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0018
885 5-hydroxytryptamine 1B receptor HTR1B 0.0018
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0018
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0018
1176 Mitogen-activated protein kinase 1 MAPK1 0.0018
2449 Tubulin alpha-3 chain TUBA1A 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
2216 Fibroblast growth factor receptor 4 FGFR4 0.0017
6228 Nuclear receptor coactivator 1 NCOA1 0.0017
4217 Telomerase reverse transcriptase TERT 0.0017
1063 Signal transducer and activator of transcription 5B STAT5B 0.0017
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0017
6241 Nuclear receptor coactivator 2 NCOA2 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0017
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0017
320 5-hydroxytryptamine 1A receptor HTR1A 0.0016
6044 Serum paraoxonase/lactonase 3 PON3 0.0016
4225 Uridine phosphorylase 1 UPP1 0.0016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0015
365 Dihydrofolate reductase DHFR 0.0015
2381 Dihydrofolate reductase DFR1 0.0015
2833 Dihydrofolate reductase Not Available 0.0015
2931 Dihydrofolate reductase folA 0.0015
3544 Dihydrofolate reductase folA 0.0015
3682 Dihydrofolate reductase folA 0.0015
6642 Dihydrofolate reductase folA 0.0015
6756 Dihydrofolate reductase dfrA 0.0015
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0015
572 Integrin alpha-L ITGAL 0.0015
474 Acetylcholinesterase ACHE 0.0015
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
357 Carbonic anhydrase 2 CA2 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0014
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
2320 Thymidine kinase, cytosolic TK1 0.0014
4122 Histone deacetylase 2 HDAC2 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
6824 Tyrosine-protein kinase Lyn LYN 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
1864 RET proto-oncogene RET 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0013
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
789 Alpha-1D adrenergic receptor ADRA1D 0.0013
760 Fibroblast growth factor 1 FGF1 0.0013
6218 Pannexin-1 PANX1 0.0013
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
751 Potassium channel subfamily K member 6 KCNK6 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0012
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0012
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0012
260 Cytochrome P450 51 ERG11 0.0011
761 Cytochrome P450 51 ERG11 0.0011
3163 Cytochrome P450 51 cyp51 0.0011
632 Alpha-1B adrenergic receptor ADRA1B 0.0011
172 Potassium channel subfamily K member 1 KCNK1 0.0011
6042 Prostaglandin reductase 2 PTGR2 0.0011
340 Apoptotic protease-activating factor 1 APAF1 0.0011
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0011
2240 Cell division protein kinase 2 CDK2 0.0011
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
6043 Putative G-protein coupled receptor 44 GPR44 0.001
284 DNA-directed RNA polymerase beta chain rpoB 0.001
5773 DNA-directed RNA polymerase beta chain rpoB 0.001
467 Delta-type opioid receptor OPRD1 0.001
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.001
825 Arsenical pump-driving ATPase ASNA1 0.001
3435 Arsenical pump-driving ATPase arsA 0.001
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.001
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.001
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.001
696 Kappa-type opioid receptor OPRK1 0.001
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.001
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.001
733 Activin receptor type 1B ACVR1B 0.001
154 AFG3-like protein 2 AFG3L2 0.001
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.001
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.001
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.001
395 ALK tyrosine kinase receptor Not Available 0.001
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.001
517 Alcohol dehydrogenase 1C ADH1C 0.0009
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0009
847 Mu-type opioid receptor OPRM1 0.0009
6014 Cytochrome P450 2A13 CYP2A13 0.0009
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0009
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0009
6493 Cytochrome c oxidase subunit 6C COX6C 0.0009
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0009
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0009
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0009
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0009
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0009
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0009
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0009
6559 Cytochrome c oxidase subunit 2 ctaC 0.0009
6669 Cytochrome c oxidase subunit 2 ctaC 0.0009
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0009
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0009
6558 Cytochrome c oxidase subunit 1 ctaD 0.0009
292 Activin receptor type-1 ACVR1 0.0009
849 Activated CDC42 kinase 1 TNK2 0.0009
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0009
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0009
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0009
297 Adenylate cyclase type 1 ADCY1 0.0009
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0008
2540 Choloylglycine hydrolase cbh 0.0008
2981 Phospholipase A2, membrane associated PLA2G2A 0.0008
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0008
6501 Fatty acid-binding protein, liver FABP1 0.0008
740 Argininosuccinate synthase ASS1 0.0007
865 Argininosuccinate synthase ASS1 0.0007
2680 Argininosuccinate synthase argG 0.0007
3194 Argininosuccinate synthase argG 0.0007
952 Dipeptidyl peptidase 4 DPP4 0.0007
6021 Adenosine kinase ADK 0.0007
661 ADP/ATP translocase 1 SLC25A4 0.0007
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0007
816 Biliverdin reductase A BLVRA 0.0007
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0007
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0007
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0006
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0006
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0006
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0006
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0006
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0006
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0006
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0006
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0006
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0006
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0006
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0006
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0006
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0006
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0006
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0006
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0006
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0006
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0006
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0006
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0006
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0006
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0006
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0006
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0006
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0006
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0006
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0006
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0006
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0006
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0006
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0006
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0006
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0006
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0006
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0006
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0006
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0006
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0006
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0006
729 GDP-L-fucose synthetase TSTA3 0.0006
3463 GDP-L-fucose synthetase fcl 0.0006
167 L-lactate dehydrogenase C chain LDHC 0.0006
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0006
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0006
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0006
3726 D-3-phosphoglycerate dehydrogenase serA 0.0006
4291 D-3-phosphoglycerate dehydrogenase serA 0.0006
206 3-keto-steroid reductase HSD17B7 0.0006
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0006
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0006
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0006
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0006
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0006
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0006
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0006
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0006
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0006
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0006
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0006
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0006
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0006
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0006
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0006
34 7-dehydrocholesterol reductase DHCR7 0.0006
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0006
711 UDP-glucose 6-dehydrogenase UGDH 0.0006
3672 UDP-glucose 6-dehydrogenase hasB 0.0006
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0006
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0006
107 C-4 methylsterol oxidase SC4MOL 0.0006
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0006
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0006
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0006
643 Peroxisomal bifunctional enzyme EHHADH 0.0006
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0006
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0006
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0006
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0006
646 Malate dehydrogenase, cytoplasmic MDH1 0.0006
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0006
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0006
328 Sorbitol dehydrogenase SORD 0.0006
396 Alcohol dehydrogenase 4 ADH4 0.0006
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0006
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0006
921 Glutamate receptor 2 GRIA2 0.0006
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0006
666 NADP-dependent malic enzyme ME1 0.0006
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0006
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0006
857 Malate dehydrogenase, mitochondrial MDH2 0.0005
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0005
77 L-lactate dehydrogenase B chain LDHB 0.0005
12 Alcohol dehydrogenase class 3 ADH5 0.0005
6026 Alcohol dehydrogenase 6 ADH6 0.0005
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0005
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0005
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0005
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0005
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0005
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0005
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0005
626 Cysteine dioxygenase type 1 CDO1 0.0005
627 11-cis retinol dehydrogenase RDH5 0.0005
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0005
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0005
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
473 L-lactate dehydrogenase A chain LDHA 0.0005
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0005
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0005
569 Retinal dehydrogenase 2 ALDH1A2 0.0005
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0005
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0005
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0005
611 Retinal dehydrogenase 1 ALDH1A1 0.0005
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0005
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0005
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0005
251 Alcohol dehydrogenase 1A ADH1A 0.0005
279 Tyrosinase TYR 0.0005
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
654 Flavin reductase BLVRB 0.0004
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0004
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0004
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0004
822 Aldose reductase AKR1B1 0.0003
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