DT-Web

DB00140 - Riboflavin


Identification
Name Riboflavin
Accession Number DB00140 (APRD00626, EXPT02760, NUTR00010)
Type small molecule
Description Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 376.3639
Groups approved
Monoisotopic Weight 376.138284392
Pharmacology
Indication For the treatment of ariboflavinosis (vitamin B2 deficiency).
Mechanism of action Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. Riboflavin is the precursor of flavin mononucleotide (FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). The antioxidant activity of riboflavin is principally derived from its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione. Reduced glutathione is the cofactor of the selenium-containing glutathione peroxidases among other things. The glutathione peroxidases are major antioxidant enzymes. Reduced glutathione is generated by the FAD-containing enzyme glutathione reductase.
Absorption Vitamin B2 is readily absorbed from the upper gastrointestinal tract.
Protein binding 60%
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Riboflavin kinase
Name Riboflavin kinase
Gene Name RFK
Pharmacological action yes
Actions ligand
References
  • Werner R, Manthey KC, Griffin JB, Zempleni J: HepG2 cells develop signs of riboflavin deficiency within 4 days of culture in riboflavin-deficient medium. J Nutr Biochem. 2005 Oct;16(10):617-24. - Pubmed
  • Solovieva IM, Kreneva RA, Errais Lopes L, Perumov DA: The riboflavin kinase encoding gene ribR of Bacillus subtilis is a part of a 10 kb operon, which is negatively regulated by the yrzC gene product. FEMS Microbiol Lett. 2005 Feb 1;243(1):51-8. - Pubmed
  • Ishchuk OP, Iatsyshyn VIu, Dmytruk KV, Voronovs'kyi AIa, Fedorovych DV, Sybirnyi AA: [Construction of the flavinogenic yeast Candida famata strains with high riboflavin kinase activity using gene engineering] Ukr Biokhim Zh. 2006 Sep-Oct;78(5):63-9. - Pubmed
  • Sandoval FJ, Roje S: An FMN hydrolase is fused to a riboflavin kinase homolog in plants. J Biol Chem. 2005 Nov 18;280(46):38337-45. Epub 2005 Sep 23. - Pubmed
  • Bertollo CM, Oliveira AC, Rocha LT, Costa KA, Nascimento EB Jr, Coelho MM: Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models. Eur J Pharmacol. 2006 Oct 10;547(1-3):184-91. Epub 2006 Jul 26. - Pubmed
  • Hirano G, Izumi H, Yasuniwa Y, Shimajiri S, Ke-Yong W, Sasagiri Y, Kusaba H, Matsumoto K, Hasegawa T, Akimoto M, Akashi K, Kohno K: Involvement of riboflavin kinase expression in cellular sensitivity against cisplatin. Int J Oncol. 2011 Apr;38(4):893-902. - Pubmed
DTHybrid score 0.4462
Riboflavin synthase alpha chain
Name Riboflavin synthase alpha chain
Gene Name ribE
Pharmacological action yes
Actions other
References
  • Kim RR, Illarionov B, Joshi M, Cushman M, Lee CY, Eisenreich W, Fischer M, Bacher A: Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion. J Am Chem Soc. 2010 Mar 10;132(9):2983-90. - Pubmed
  • Long Q, Ji L, Wang H, Xie J: Riboflavin biosynthetic and regulatory factors as potential novel anti-infective drug targets. Chem Biol Drug Des. 2010 Apr;75(4):339-47. Epub 2010 Feb 8. - Pubmed
DTHybrid score 0.5437
Flavin reductase
Name Flavin reductase
Gene Name BLVRB
Pharmacological action yes
Actions product of
References
  • Russell TR, Demeler B, Tu SC: Kinetic mechanism and quaternary structure of Aminobacter aminovorans NADH:flavin oxidoreductase: an unusual flavin reductase with bound flavin. Biochemistry. 2004 Feb 17;43(6):1580-90. - Pubmed
  • van Pee KH, Patallo EP: Flavin-dependent halogenases involved in secondary metabolism in bacteria. Appl Microbiol Biotechnol. 2006 May;70(6):631-41. Epub 2006 Mar 17. - Pubmed
DTHybrid score 0.8226

Enzymes


Amine oxidase [flavin-containing] A
Name Amine oxidase [flavin-containing] A
Gene Name MAOA
Actions cofactor
References
  • Strolin Benedetti M, Tipton KF, Whomsley R: Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected? Fundam Clin Pharmacol. 2007 Oct;21(5):467-80. - Pubmed
DTHybrid score 0.5582
Methylenetetrahydrofolate reductase
Name Methylenetetrahydrofolate reductase
Gene Name MTHFR
Actions cofactor
References
  • Bates CJ, Fuller NJ: The effect of riboflavin deficiency on methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.20) and folate metabolism in the rat. Br J Nutr. 1986 Mar;55(2):455-64. - Pubmed
  • Macdonald HM, McGuigan FE, Fraser WD, New SA, Ralston SH, Reid DM: Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density. Bone. 2004 Oct;35(4):957-64. - Pubmed
DTHybrid score 0.3594

Transporters


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. - Pubmed
DTHybrid score 0.3762

Predictions


Id Partner name Gene Name Score
3939 Amine oxidase [flavin-containing] B MAOB 0.1689
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.1473
810 Heme oxygenase 1 HMOX1 0.0989
3391 Heme oxygenase 1 pbsA1 0.0989
6142 Solute carrier family 22 member 8 SLC22A8 0.0596
4200 Cytochrome P450 1A2 CYP1A2 0.0514
1024 Solute carrier family 22 member 11 SLC22A11 0.0451
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0432
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0418
6143 Solute carrier family 22 member 7 SLC22A7 0.0377
4757 Cytochrome P450 2C9 CYP2C9 0.0358
587 Serum albumin ALB 0.034
824 Sodium-dependent serotonin transporter SLC6A4 0.0339
511 5-hydroxytryptamine 1F receptor HTR1F 0.0325
713 Sodium-dependent dopamine transporter SLC6A3 0.032
4119 Cytochrome P450 2D6 CYP2D6 0.0314
809 Methionine synthase MTR 0.0307
2935 Methionine synthase metH 0.0307
244 Angiotensin-converting enzyme ACE 0.0303
4512 Cytochrome P450 3A4 CYP3A4 0.0298
2164 Multidrug resistance-associated protein 4 ABCC4 0.0297
6016 Cytochrome P450 2C19 CYP2C19 0.0291
1588 Multidrug resistance protein 1 ABCB1 0.028
725 5-hydroxytryptamine 1D receptor HTR1D 0.0262
885 5-hydroxytryptamine 1B receptor HTR1B 0.0258
20 Prostaglandin G/H synthase 1 PTGS1 0.0256
290 Prostaglandin G/H synthase 2 PTGS2 0.025
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0245
6013 Cytochrome P450 2E1 CYP2E1 0.0243
293 Gamma-glutamyl hydrolase GGH 0.0242
840 Methionine synthase reductase, mitochondrial MTRR 0.0238
5189 Trimethylamine dehydrogenase tmd 0.023
4924 Cytochrome P450 2C8 CYP2C8 0.0229
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.022
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0217
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0217
118 Organic cation/carnitine transporter 2 SLC22A5 0.0206
1650 Heme carrier protein 1 SLC46A1 0.0205
718 Folate receptor gamma FOLR3 0.0199
804 Mitochondrial folate transporter/carrier SLC25A32 0.0199
299 Folate receptor beta FOLR2 0.0199
5198 Flavodoxin-1 fldA 0.0196
3293 Flavodoxin Not Available 0.0196
4614 Flavodoxin DVU_2680 0.0196
5172 Flavodoxin isiB 0.0196
5173 Flavodoxin isiB 0.0196
5182 Flavodoxin fldA 0.0196
5201 FMN-binding protein DvMF_2023 0.0196
5178 Protein nrdI nrdI 0.0196
5181 Hypothetical protein yhdA azr 0.0196
5193 Phenazine biosynthesis protein phzG phzG 0.0196
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0196
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0196
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0196
5179 Probable aromatic acid decarboxylase pad1 0.0196
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0196
5200 NADH dehydrogenase nox 0.0196
5170 Epidermin decarboxylase epiD 0.0196
5175 Hypothetical protein SMU.260 SMU_260 0.0196
5202 Nitroreductase family protein BC_1844 0.0196
5131 PhzG phzG 0.0196
5191 Morphinone reductase morB 0.0196
4405 Nitric oxide reductase fprA 0.0196
4037 Hypothetical protein GPX1 0.0196
4297 Hypothetical protein SP_1951 0.0196
4521 Hypothetical protein BC_2969 0.0196
4540 Hypothetical protein TM_1070 0.0196
4555 Hypothetical protein MT1739 0.0196
4569 Hypothetical protein mshD 0.0196
4578 Hypothetical protein PA3270 0.0196
4747 Hypothetical protein PA3967 0.0196
5177 Hypothetical protein TM_0096 0.0196
5194 Hypothetical protein PA1204 0.0196
5240 Hypothetical protein Rv2991 0.0196
5370 Hypothetical protein TM_1158 0.0196
5710 Hypothetical protein Tb927.5.1360 0.0196
5190 Rubredoxin-oxygen oxidoreductase roo 0.0196
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0191
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0191
5718 Cytochrome P450 2A6 CYP2A6 0.0189
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0186
131 Synaptic vesicular amine transporter SLC18A2 0.0179
3639 Thymidine phosphorylase deoA 0.0176
3936 Thymidine phosphorylase TYMP 0.0176
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0174
4503 NADPH-flavin oxidoreductase frp 0.0173
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.0173
3680 Dihydroorotate dehydrogenase A pyrDA 0.0164
5176 YtnJ moxC 0.0164
556 Alpha-1A adrenergic receptor ADRA1A 0.0164
318 Alpha-2A adrenergic receptor ADRA2A 0.0163
4407 FMN-dependent NADH-azoreductase azoR 0.0163
5169 FMN-dependent NADH-azoreductase azoR 0.0163
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0162
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0162
3507 Chorismate synthase aroC 0.0161
5171 Chorismate synthase aroC 0.0161
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0161
3810 Catechol O-methyltransferase COMT 0.0153
592 Carbonic anhydrase 4 CA4 0.0152
507 Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial MMAB 0.0152
3916 Methylmalonic aciduria and homocystinuria type C protein MMACHC 0.0152
354 Methylmalonic aciduria type A protein, mitochondrial MMAA 0.0152
398 Transcobalamin-2 TCN2 0.0152
265 Transcobalamin-1 TCN1 0.0152
376 Amnionless protein AMN 0.0152
854 Methylmalonyl-CoA mutase, mitochondrial MUT 0.0152
1224 Cubilin CUBN 0.0152
633 Penicillin-binding proteins 1A/1B pbpA 0.0149
2775 Dihydroorotate dehydrogenase pyrD 0.0148
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0147
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0146
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0146
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
295 Carbonic anhydrase 1 CA1 0.0144
320 5-hydroxytryptamine 1A receptor HTR1A 0.0143
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0139
5180 L(+)-mandelate dehydrogenase mdlB 0.0137
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0137
24 Thymidylate synthase TMP1 0.0135
359 Thymidylate synthase TYMS 0.0135
2626 Thymidylate synthase thyA 0.0135
2729 Thymidylate synthase thyA 0.0135
5352 Thymidylate synthase THYA 0.0135
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0132
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0131
862 Multidrug resistance-associated protein 1 ABCC1 0.0128
4120 NADPH--cytochrome P450 reductase POR 0.0128
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0126
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0126
76 Nitric-oxide synthase, brain NOS1 0.0125
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0125
357 Carbonic anhydrase 2 CA2 0.0124
738 Monocarboxylate transporter 1 SLC16A1 0.0123
317 Methionine-R-sulfoxide reductase SEPX1 0.0123
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0122
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0122
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0122
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0122
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
4284 Pentaerythritol tetranitrate reductase onr 0.0122
6024 Cytochrome P450 1A1 CYP1A1 0.012
6020 Aldehyde oxidase AOX1 0.012
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0117
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0117
338 DNA polymerase UL30 0.0116
379 DNA polymerase UL54 0.0116
697 DNA polymerase ORF28 0.0116
2482 DNA polymerase 43 0.0116
4104 DNA polymerase BALF5 0.0116
6268 Hydroxyacid oxidase 1 HAO1 0.0115
6145 Solute carrier family 22 member 1 SLC22A1 0.0114
193 Beta-1 adrenergic receptor ADRB1 0.0113
6136 Multidrug resistance-associated protein 5 ABCC5 0.0112
4790 Glycosyltransferase GtfA gtfA 0.011
146 Androgen receptor AR 0.011
4226 Uridine phosphorylase 2 UPP2 0.011
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0109
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0109
59 AMT protein AMT 0.0109
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0109
400 Coagulation factor IX F9 0.0107
5461 Coagulation factor IX F9 0.0107
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0106
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0104
191 Peptide methionine sulfoxide reductase MSRA 0.0102
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.01
645 Penicillin-binding protein 1A mrcA 0.01
5805 Penicillin-binding protein 1A ponA 0.01
6185 Penicillin-binding protein 1A mrcA 0.01
6799 Penicillin-binding protein 1A pbpA 0.01
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.01
604 Vitamin K-dependent protein Z PROZ 0.01
13 Aminomethyltransferase, mitochondrial AMT 0.0099
6126 Carbonic anhydrase 7 CA7 0.0095
6147 Solute carrier family 22 member 3 SLC22A3 0.0095
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0095
6144 Solute carrier family 22 member 2 SLC22A2 0.0094
23 D(1A) dopamine receptor DRD1 0.0094
4225 Uridine phosphorylase 1 UPP1 0.0094
413 Amidophosphoribosyltransferase PPAT 0.0094
2515 Amidophosphoribosyltransferase purF 0.0094
3714 Amidophosphoribosyltransferase purF 0.0094
3811 Cytochrome P450 19A1 CYP19A1 0.0093
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0093
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.009
1245 Vitamin K-dependent protein S PROS1 0.009
422 Vitamin K-dependent protein C PROC 0.009
1757 Myeloperoxidase MPO 0.0087
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0087
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
5294 Nucleoside diphosphate kinase A NME1 0.0082
2016 Dipeptidase 1 DPEP1 0.0082
3884 SHMT2 protein SHMT2 0.0081
3901 SHMT2 protein SHMT2 0.0081
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0081
3879 Serine hydroxymethyltransferase 2 Not Available 0.0081
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0081
448 Vitamin K-dependent gamma-carboxylase GGCX 0.008
5818 Folate receptor alpha FOLR1 0.0079
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0079
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0078
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0078
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0078
833 Organic cation/carnitine transporter 1 SLC22A4 0.0078
4118 Cytochrome P450 3A5 CYP3A5 0.0078
543 Penicillin-binding protein 1B mrcB 0.0077
6186 Penicillin-binding protein 1B ponB 0.0077
6822 Penicillin-binding protein 1b pbp1b 0.0077
6844 Penicillin-binding protein 1b pbp1b 0.0077
6107 Cytochrome P450 3A7 CYP3A7 0.0076
365 Dihydrofolate reductase DHFR 0.0074
2381 Dihydrofolate reductase DFR1 0.0074
2833 Dihydrofolate reductase Not Available 0.0074
2931 Dihydrofolate reductase folA 0.0074
3544 Dihydrofolate reductase folA 0.0074
3682 Dihydrofolate reductase folA 0.0074
6642 Dihydrofolate reductase folA 0.0074
6756 Dihydrofolate reductase dfrA 0.0074
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0074
6030 Cytochrome P450 2B6 CYP2B6 0.0073
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0073
22 30S ribosomal protein S4 rpsD 0.0072
6714 30S ribosomal protein S4 rpsD 0.0072
776 Bile salt export pump ABCB11 0.0072
798 Osteocalcin BGLAP 0.0071
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0071
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
6148 Multidrug resistance-associated protein 7 ABCC10 0.0071
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.007
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0069
140 30S ribosomal protein S9 rpsI 0.0068
6719 30S ribosomal protein S9 rpsI 0.0068
6725 30S ribosomal protein S9 rpsI 0.0068
789 Alpha-1D adrenergic receptor ADRA1D 0.0068
502 5-hydroxytryptamine 2A receptor HTR2A 0.0067
5287 Signaling protein Not Available 0.0067
5304 UPF0166 protein TM_0021 TM_0021 0.0067
5276 Chromosomal replication initiator protein dnaA dnaA 0.0067
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0067
3199 Phosphopantetheine adenylyltransferase coaD 0.0067
3543 Phosphopantetheine adenylyltransferase coaD 0.0067
3567 Phosphopantetheine adenylyltransferase coaD 0.0067
5289 Phosphopantetheine adenylyltransferase coaD 0.0067
2874 Nitrogenase iron protein 1 nifH1 0.0067
5293 Shikimate kinase 2 aroL 0.0067
5288 Shikimate kinase aroK 0.0067
5299 D-alanine--D-alanine ligase ddl 0.0067
6598 D-alanine--D-alanine ligase ddl 0.0067
4346 Polynucleotide kinase pseT 0.0067
5259 Transcriptional regulator ntrC1 0.0067
6699 Transcriptional regulator Cgl2612 0.0067
5292 Putative partitioning protein TT_C1605 0.0067
5266 Activator of hgdC 0.0067
5264 DNA replication protein REP 0.0067
5283 D-alanine--D-alanine ligase B ddlB 0.0067
5281 Plasmid segregation protein parM parM 0.0067
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0067
5315 Chaperone protein htpG htpG 0.0067
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0067
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0067
5284 Large T antigen Not Available 0.0067
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0067
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0067
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0067
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0067
5277 Preprotein translocase subunit secA secA 0.0067
5291 Glycogen synthase 1 glgA1 0.0067
5308 Preprotein translocase secA 1 subunit secA1 0.0067
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0067
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0067
5261 Phosphoribosylformylglycinamidine synthase purL 0.0067
5285 Kinesin heavy chain KIF5B 0.0067
2795 Methionine aminopeptidase 2 METAP2 0.0066
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0066
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0066
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
3947 Xanthine dehydrogenase/oxidase XDH 0.0064
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0063
666 NADP-dependent malic enzyme ME1 0.0062
369 Coagulation factor VII F7 0.0062
646 Malate dehydrogenase, cytoplasmic MDH1 0.0061
632 Alpha-1B adrenergic receptor ADRA1B 0.0061
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.006
5626 Nucleoside diphosphate kinase B NME2 0.006
11 NAD(P) transhydrogenase, mitochondrial NNT 0.006
766 Beta-2 adrenergic receptor ADRB2 0.0059
2320 Thymidine kinase, cytosolic TK1 0.0059
4773 Deoxycytidine kinase DCK 0.0059
558 Solute carrier family 12 member 1 SLC12A1 0.0059
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0059
5073 Ferredoxin--NADP reductase petH 0.0058
5076 Ferredoxin--NADP reductase fpr 0.0058
5119 Ferredoxin--NADP reductase petH 0.0058
5121 Ferredoxin--NADP reductase fpr 0.0058
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0058
6151 Monocarboxylate transporter 10 SLC16A10 0.0058
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0058
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0058
5332 MtdA bifunctional protein mtdA 0.0058
5322 Oxidoreductase ydhF ydhF 0.0058
4403 Protein iolS iolS 0.0058
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0058
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0058
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0058
3778 NAD(P) transhydrogenase subunit beta pntB 0.0058
5330 General stress protein 69 yhdN 0.0058
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0058
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0058
6031 Cytochrome P450 3A43 CYP3A43 0.0058
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0057
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0057
4106 Guanylate kinase GUK1 0.0056
4516 Guanylate kinase gmk 0.0056
6277 Heat shock cognate 71 kDa protein HSPA8 0.0056
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0056
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0056
4837 Cag-alfa cag-alfa 0.0056
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0056
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0056
5302 TrwB trwB 0.0056
4774 NTPase P4 Not Available 0.0056
5265 FtsH ftsH 0.0056
5646 Galactokinase GALK1 0.0056
4838 PMS1 protein homolog 2 PMS2 0.0056
4839 DNA polymerase III subunit tau dnaX 0.0056
2270 Dephospho-CoA kinase coaE 0.0055
2284 Adenylate kinase adk 0.0055
2296 Adenylate kinase adk 0.0055
2311 Adenylate kinase adk 0.0055
2312 Adenylate kinase Not Available 0.0055
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0055
6141 Sodium/bile acid cotransporter SLC10A1 0.0055
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0055
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
3470 Hypothetical protein MG245 homolog MPN_348 0.0055
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0054
3426 Glutamine synthetase glnA 0.0054
3987 Glutamine synthetase GLUL 0.0054
3175 Glutamate--cysteine ligase gshA 0.0054
6014 Cytochrome P450 2A13 CYP2A13 0.0054
340 Apoptotic protease-activating factor 1 APAF1 0.0054
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0053
378 Alpha-2C adrenergic receptor ADRA2C 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0052
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0052
822 Aldose reductase AKR1B1 0.0052
6131 Carbonic anhydrase 14 CA14 0.0052
629 Alpha-2B adrenergic receptor ADRA2B 0.0052
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0052
702 UMP-CMP kinase CMPK1 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
2683 Mono-ADP-ribosyltransferase C3 C3 0.0051
5300 Antigen peptide transporter 1 TAP1 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
2390 Nonsecretory ribonuclease RNASE2 0.0051
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0051
5312 Kinesin-like protein KIF1A KIF1A 0.005
2922 Glycerol kinase glpK 0.005
5271 Focal adhesion kinase 1 PTK2 0.0049
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0049
4582 Putative pteridine reductase 2 ptr2 0.0049
2636 Shikimate dehydrogenase aroE 0.0049
3515 Shikimate dehydrogenase aroE 0.0049
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0049
2282 Protein recA recA 0.0049
2315 Protein recA recA 0.0049
2332 Protein recA recA 0.0049
5263 Protein recA recA 0.0049
3446 NADP-dependent alcohol dehydrogenase adh 0.0049
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0049
989 L-xylulose reductase DCXR 0.0049
2286 Isocitrate dehydrogenase [NADP] icd 0.0049
2302 Isocitrate dehydrogenase [NADP] icd 0.0049
2771 Isocitrate dehydrogenase [NADP] icd 0.0049
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0049
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0049
5328 Prostaglandin F synthase Tb11.02.2310 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
6122 Carbonic anhydrase 3 CA3 0.0049
2615 Chemotaxis protein cheA cheA 0.0047
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0047
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0047
3007 Carbonic anhydrase 12 CA12 0.0047
4205 Carbonic anhydrase 9 CA9 0.0047
2371 Pantothenate kinase coaA 0.0047
3669 Ribokinase rbsK 0.0046
1881 Hexokinase-1 HK1 0.0046
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0046
239 Coagulation factor X F10 0.0046
2892 Acetylglutamate kinase argB 0.0046
3550 Acetylglutamate kinase argB 0.0046
825 Arsenical pump-driving ATPase ASNA1 0.0046
3435 Arsenical pump-driving ATPase arsA 0.0046
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0046
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0046
373 Transthyretin TTR 0.0046
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0046
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0045
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0045
444 Alcohol dehydrogenase 1B ADH1B 0.0045
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0045
6297 Prostaglandin reductase 1 PTGR1 0.0045
6106 Cytochrome P450 2C18 CYP2C18 0.0045
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0045
4531 Putative ketoacyl reductase actIII 0.0045
3062 Aspartate-semialdehyde dehydrogenase asd 0.0045
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
2727 S-adenosylmethionine synthetase metK 0.0044
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0044
788 Creatine kinase M-type CKM 0.0044
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0044
2675 Pteridine reductase 1 PTR1 0.0043
817 DNA topoisomerase 2-alpha TOP2A 0.0043
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0043
2697 Uridine-cytidine kinase 2 UCK2 0.0043
1124 Sepiapterin reductase SPR 0.0042
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0042
2159 Quinone oxidoreductase CRYZ 0.0042
831 D(2) dopamine receptor DRD2 0.0042
3913 Glutamic acid decarboxylase GAD65 0.0042
2334 Dethiobiotin synthetase bioD 0.0042
6555 Dethiobiotin synthetase bioD 0.0042
115 Penicillin-binding protein 2 mrdA 0.0041
6069 Penicillin-binding protein 2 mrdA 0.0041
6118 Penicillin-binding protein 2 penA 0.0041
6187 Penicillin-binding protein 2 pbpA 0.0041
6686 Penicillin-binding protein 2 pbp2 0.0041
6939 Penicillin-binding protein 2 mrdA 0.0041
7163 Penicillin-binding protein 2 pbpA 0.0041
1636 Trace amine-associated receptor 1 TAAR1 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0041
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0041
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0041
48 Pyridoxal kinase PDXK 0.0041
275 Arachidonate 5-lipoxygenase ALOX5 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.004
1656 CYP2B protein CYP2B 0.0039
2091 Endoplasmin HSP90B1 0.0039
207 Glutathione synthetase GSS 0.0039
5269 Glutathione synthetase gshB 0.0039
2251 Thymidylate kinase tmk 0.0039
2254 Thymidylate kinase DTYMK 0.0039
3522 Thymidylate kinase tmk 0.0039
1483 Membrane copper amine oxidase AOC3 0.0039
1 Peptidoglycan synthetase ftsI ftsI 0.0038
4155 Peptidoglycan synthetase ftsI ftsI 0.0038
6395 Myosin-14 MYH14 0.0038
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0038
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0038
54 Prothrombin F2 0.0038
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0037
5353 Glutamate decarboxylase alpha gadA 0.0037
1422 Serine/threonine-protein kinase 6 AURKA 0.0037
1517 Beta-3 adrenergic receptor ADRB3 0.0037
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0036
3379 Kinesin-like protein KIF11 KIF11 0.0036
436 5-hydroxytryptamine 2B receptor HTR2B 0.0036
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0036
492 Histamine H1 receptor HRH1 0.0035
504 Mast/stem cell growth factor receptor KIT 0.0035
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0035
3822 Actin, alpha skeletal muscle ACTA1 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0035
735 Alanine aminotransferase 1 GPT 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
1721 Glycogen synthase kinase-3 beta GSK3B 0.0032
6149 Solute carrier family 22 member 10 SLC22A10 0.0032
590 5-hydroxytryptamine 2C receptor HTR2C 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
474 Acetylcholinesterase ACHE 0.003
5682 Ribonuclease pancreatic RNASE1 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.003
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
6043 Putative G-protein coupled receptor 44 GPR44 0.0028
380 Cytochrome P450 17A1 CYP17A1 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
1867 Major prion protein PRNP 0.0028
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0028
1025 Aquaporin-1 AQP1 0.0027
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
130 Prostacyclin synthase PTGIS 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0025
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0025
153 Dopamine beta-hydroxylase DBH 0.0025
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0024
6207 30S ribosomal protein S14 rpsN 0.0024
6209 30S ribosomal protein S19 rpsS 0.0024
6712 30S ribosomal protein S19 rpsS 0.0024
6726 30S ribosomal protein S19 rpsS 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
6167 Organic solute transporter subunit beta OSTB 0.0023
4760 Mll3241 protein mll3241 0.0023
6166 Organic solute transporter subunit alpha OSTA 0.0023
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0022
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0022
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
6033 High affinity interleukin-8 receptor A CXCR1 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0021
527 Prostacyclin receptor PTGIR 0.0021
672 Prostaglandin F2-alpha receptor PTGFR 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
6133 Sodium channel subunit beta-2 SCN2B 0.002
6134 Sodium channel subunit beta-3 SCN3B 0.002
6132 Sodium channel subunit beta-1 SCN1B 0.002
6135 Sodium channel subunit beta-4 SCN4B 0.002
6127 Carbonic anhydrase-related protein CA8 0.002
6129 Carbonic anhydrase-related protein 11 CA11 0.002
6128 Carbonic anhydrase-related protein 10 CA10 0.002
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.002
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.002
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.002
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
163 D(1B) dopamine receptor DRD5 0.0019
1654 Interleukin-1 beta IL1B 0.0019
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
816 Biliverdin reductase A BLVRA 0.0018
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0018
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0018
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0018
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0018
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0018
6130 Carbonic anhydrase 13 CA13 0.0018
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0018
432 D(4) dopamine receptor DRD4 0.0018
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0018
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0018
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0018
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0018
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0018
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0018
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0018
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0018
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0018
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0018
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0018
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0018
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0018
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0018
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0018
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0018
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0018
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0018
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0018
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0018
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0018
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0018
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0018
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0018
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0018
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0018
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0018
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0018
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0018
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0018
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0018
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0018
107 C-4 methylsterol oxidase SC4MOL 0.0018
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0018
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0018
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0018
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0018
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0018
711 UDP-glucose 6-dehydrogenase UGDH 0.0018
3672 UDP-glucose 6-dehydrogenase hasB 0.0018
729 GDP-L-fucose synthetase TSTA3 0.0018
3463 GDP-L-fucose synthetase fcl 0.0018
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0018
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0018
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0018
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0018
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0018
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0018
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0018
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0018
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0018
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0018
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0018
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0018
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0018
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0018
34 7-dehydrocholesterol reductase DHCR7 0.0018
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0018
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0018
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0018
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0018
3726 D-3-phosphoglycerate dehydrogenase serA 0.0018
4291 D-3-phosphoglycerate dehydrogenase serA 0.0018
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0018
644 Heme oxygenase 2 HMOX2 0.0018
4982 Heme oxygenase 2 pbsA2 0.0018
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0018
167 L-lactate dehydrogenase C chain LDHC 0.0018
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0018
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0018
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0018
206 3-keto-steroid reductase HSD17B7 0.0018
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0018
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0018
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0018
643 Peroxisomal bifunctional enzyme EHHADH 0.0018
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0018
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0018
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0018
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0018
638 D(3) dopamine receptor DRD3 0.0017
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0017
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
857 Malate dehydrogenase, mitochondrial MDH2 0.0017
714 Glutathione reductase, mitochondrial GSR 0.0017
328 Sorbitol dehydrogenase SORD 0.0017
597 Dihydropteridine reductase QDPR 0.0017
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0017
396 Alcohol dehydrogenase 4 ADH4 0.0017
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0017
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0016
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0016
12 Alcohol dehydrogenase class 3 ADH5 0.0016
77 L-lactate dehydrogenase B chain LDHB 0.0016
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0016
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0016
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0016
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0016
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0016
473 L-lactate dehydrogenase A chain LDHA 0.0016
494 Caspase-1 CASP1 0.0015
183 Vascular endothelial growth factor A VEGFA 0.0015
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0015
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0015
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0015
6026 Alcohol dehydrogenase 6 ADH6 0.0015
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0015
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0015
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0015
1507 Cytochrome c CYCS 0.0015
756 Sex hormone-binding globulin SHBG 0.0015
1405 Thiopurine S-methyltransferase TPMT 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0014
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0014
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0014
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0014
626 Cysteine dioxygenase type 1 CDO1 0.0014
627 11-cis retinol dehydrogenase RDH5 0.0014
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0014
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0014
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0014
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0014
4217 Telomerase reverse transcriptase TERT 0.0014
3760 Penicillin-binding protein 5 precursor dacA 0.0014
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0014
569 Retinal dehydrogenase 2 ALDH1A2 0.0013
611 Retinal dehydrogenase 1 ALDH1A1 0.0013
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0013
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0013
251 Alcohol dehydrogenase 1A ADH1A 0.0013
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0013
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0013
2077 Caspase-3 CASP3 0.0013
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0013
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0013
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0013
819 Penicillin-binding protein 4 dacB 0.0012
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0012
1898 Cytochrome P450 1B1 CYP1B1 0.0012
279 Tyrosinase TYR 0.0012
2981 Phospholipase A2, membrane associated PLA2G2A 0.0012
517 Alcohol dehydrogenase 1C ADH1C 0.0012
6137 Multidrug resistance-associated protein 6 ABCC6 0.0012
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0011
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0011
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0011
2021 Thrombomodulin THBD 0.0011
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0011
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0011
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0011
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.001
70 Type-1 angiotensin II receptor AGTR1 0.001
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.001
997 Protein kinase C beta type PRKCB 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
220 Sodium channel protein type 5 subunit alpha SCN5A 0.001
468 Cytochrome P450 4A11 CYP4A11 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
6218 Pannexin-1 PANX1 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
1039 Histone deacetylase 9 HDAC9 0.0009
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0009
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
4439 Ferredoxin reductase bphA4 0.0009
4486 Phenol 2-hydroxylase component B pheA2 0.0009
4477 Dihydrolipoyl dehydrogenase lpdV 0.0009
5077 Dihydrolipoyl dehydrogenase Not Available 0.0009
5117 Dihydrolipoyl dehydrogenase lpd 0.0009
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
5078 Amine oxidase, flavin-containing PSPTO1126 0.0009
5095 Putidaredoxin reductase camA 0.0009
5122 Mersacidin decarboxylase mrsD 0.0009
526 Thioredoxin reductase trxB 0.0009
3767 Thioredoxin reductase trxB 0.0009
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0009
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5109 Outer membrane protein p64k or PM-6 m-6 0.0009
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0009
5115 FkbI fkbI 0.0009
3133 UDP-galactopyranose mutase glf 0.0009
5099 UDP-galactopyranose mutase glf 0.0009
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0009
5083 Cryptochrome DASH cry 0.0009
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0009
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0009
3763 5,10-methylenetetrahydrofolate reductase metF 0.0009
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0009
5094 5,10-methylenetetrahydrofolate reductase metF 0.0009
5081 L-aspartate oxidase nadB 0.0009
5111 Phenylacetone monooxygenase pamO 0.0009
1410 Oxidoreductase HSD17B6 0.0008
4725 Oxidoreductase Not Available 0.0008
5124 Oxidoreductase Not Available 0.0008
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0008
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0008
3587 Gastrotropin FABP6 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0008
4440 NADH peroxidase npr 0.0008
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0008
3102 Flavohemoprotein hmp 0.0008
4969 Flavohemoprotein hmp 0.0008
273 Apoptosis regulator Bcl-2 BCL2 0.0008
327 Glutathione reductase gor 0.0007
5110 Glutathione reductase GR2 0.0007
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0007
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0007
3594 Deoxyribodipyrimidine photo-lyase phr 0.0007
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0007
5080 Deoxyribodipyrimidine photo-lyase phr 0.0007
5072 N,N-dimethylglycine oxidase dmg 0.0007
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0007
2470 Pyruvate oxidase pox5 0.0007
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0007
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0007
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0007
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0007
2268 Cholesterol oxidase choB 0.0007
2822 Cholesterol oxidase choA 0.0007
2526 NADPH-ferredoxin reductase fprA fprA 0.0007
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0007
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0007
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0007
6085 Fatty acid-binding protein, intestinal FABP2 0.0007
126 D-lactate dehydrogenase dld 0.0007
3545 D-lactate dehydrogenase Not Available 0.0007
4510 D-lactate dehydrogenase ldhA 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
605 Fumarate reductase flavoprotein subunit frdA 0.0007
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0007
3673 Fumarate reductase flavoprotein subunit fccA 0.0007
4912 Fumarate reductase flavoprotein subunit ifcA 0.0007
6549 Fumarate reductase flavoprotein subunit frdA 0.0007
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0007
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0007
2893 Glycine oxidase thiO 0.0007
33 Cystine/glutamate transporter SLC7A11 0.0007
2769 P-hydroxybenzoate hydroxylase pobA 0.0006
2809 P-hydroxybenzoate hydroxylase pobA 0.0006
2567 Thymidylate synthase thyX thyX 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
2823 Trypanothione reductase TPR 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0006
124 Histamine H2 receptor HRH2 0.0006
489 Monocarboxylate transporter 2 SLC16A7 0.0006
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0006
6645 D-amino-acid oxidase DAO 0.0006
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0006
2380 Monomeric sarcosine oxidase soxA 0.0006
4604 Liver carboxylesterase 1 CES1 0.0005
136 Estrogen receptor ESR1 0.0005
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