DT-Web: DB00876

Identification

Name

Eprosartan

Accession Number

DB00876 (APRD00950)

Type

small molecule

Description

Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. It acts on the renin-angiotensin system in two ways to decrease total peripheral resistance. First, it blocks the binding of angiotensin II to AT1 receptors in vascular smooth muscle, causing vascular dilatation. Second, it inhibits sympathetic norepinephrine production, further reducing blood pressure.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

424.513

Groups

approved

Monoisotopic Weight

424.145677956

Pharmacology

Indication

For the management of hypertension alone or in combination with other classes of antihypertensive agents. Also used as a first-line agent in the treatment of diabetic nephropathy, as well as a second-line agent in the treatment of congestive heart failure (only in those intolerant of ACE inhibitors).

Mechanism of action

Eprosartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT₁ receptor found in many tissues (e.g., vascular smooth muscle, adrenal gland). There is also an AT₂ receptor found in many tissues but it is not known to be associated with cardiovascular homeostasis. Eprosartan does not exhibit any partial agonist activity at the AT₁ receptor. Its affinity for the AT₁ receptor is 1,000 times greater than for the AT₂ receptor. In vitro binding studies indicate that eprosartan is a reversible, competitive inhibitor of the AT₁ receptor. Eprosartan has also been shown to bind to AT₁ receptors both presynaptically and synaptically. Its action on presynaptic AT₁ receptors results in the inhibition of sympathetically stimulated noradrenaline release. Unlike ACE inhibitors, eprosartan and other ARBs do not interfere with response to bradykinins and substance P, which allows for the absence of adverse effects that are present in ACE inhibitors (eg. dry cough).

Absorption

Absolute bioavailability following a single 300 mg oral dose of eprosartan is approximately 13%. Administering eprosartan with food delays absorption.

Protein binding

Plasma protein binding of eprosartan is high (approximately 98%) and constant over the concentration range achieved with therapeutic doses.

Biotransformation

Eprosartan is not metabolized by the cytochrome P450 system. It is mainly eliminated as unchanged drug. Less than 2% of an oral dose is excreted in the urine as a glucuronide.

Route of elimination

Not Available

Toxicity

There was no mortality in rats and mice receiving oral doses of up to 3000 mg eprosartan/kg and in dogs receiving oral doses of up to 1000 mg eprosartan/kg.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amiloride	Increased risk of hyperkalemia
Drospirenone	Increased risk of hyperkalemia
Lithium	The ARB increases serum levels of lithium
Potassium	Increased risk of hyperkalemia
Spironolactone	Increased risk of hyperkalemia
Trandolapril	The angiotensin II receptor blocker, Eprosartan, may increase the adverse effects of Trandolapril.
Treprostinil	Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Triamterene	Increased risk of hyperkalemia

Food Interactions

Take without regard to meals.

Type-1 angiotensin II receptor
Name	Type-1 angiotensin II receptor
Gene Name	AGTR1
Pharmacological action	yes
Actions	antagonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Heusser K, Vitkovsky J, Schmieder RE, Schobel HP: AT1 antagonism by eprosartan lowers heart rate variability and baroreflex gain. Auton Neurosci. 2003 Aug 29;107(1):45-51. - Pubmed Gremmler B, Kunert M, Schleiting H, Ulbricht LJ: Improvement of cardiac output in patients with severe heart failure by use of ACE-inhibitors combined with the AT1-antagonist eprosartan. Eur J Heart Fail. 2000 Jun;2(2):183-7. - Pubmed Suzuki G, Mishima T, Tanhehco EJ, Sharov VG, Todor A, Rostogi S, Gupta RC, Chaudhry PA, Anagnostopoulos PV, Nass O, Goldstein S, Sabbah HN: Effects of the AT1-receptor antagonist eprosartan on the progression of left ventricular dysfunction in dogs with heart failure. Br J Pharmacol. 2003 Jan;138(2):301-9. - Pubmed Ilson BE, Martin DE, Boike SC, Jorkasky DK: The effects of eprosartan, an angiotensin II AT1 receptor antagonist, on uric acid excretion in patients with mild to moderate essential hypertension. J Clin Pharmacol. 1998 May;38(5):437-41. - Pubmed Nap A, Mathy MJ, Balt JC, Pfaffendorf M, van Zwieten PA: Pre- and postsynaptic inhibitory potencies of the angiotensin AT1 receptor antagonists eprosartan and candesartan. Eur J Pharmacol. 2003 May 23;469(1-3):117-24. - Pubmed Hedner T: The clinical profile of the angiotensin II receptor blocker eprosartan. J Hypertens Suppl. 2002 Jun;20(5):S33-8. - Pubmed Puig JG, Lopez MA, Bueso TS, Bernardino JI, Jimenez RT: Clinical profile of eprosartan. Cardiovasc Drugs Ther. 2002 Dec;16(6):543-9. - Pubmed Ruilope L, Jager B: Eprosartan for the treatment of hypertension. Expert Opin Pharmacother. 2003 Jan;4(1):107-14. - Pubmed de la Sierra A, Ram CV: Introduction: The pharmacological profile of eprosartan--implications for cerebrovascular and cardiovascular risk reduction. Curr Med Res Opin. 2007 Nov;23 Suppl 5:S1-3. - Pubmed Murdoch DR, McDonagh TA, Farmer R, Morton JJ, McMurray JJ, Dargie HJ: ADEPT: Addition of the AT1 receptor antagonist eprosartan to ACE inhibitor therapy in chronic heart failure trial: hemodynamic and neurohormonal effects. Am Heart J. 2001 May;141(5):800-7. - Pubmed
DTHybrid score	0.6891

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2525

Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	inducer
References	Weiss J, Sauer A, Divac N, Herzog M, Schwedhelm E, Boger RH, Haefeli WE, Benndorf RA: Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters. Biopharm Drug Dispos. 2010 Mar;31(2-3):150-61. - Pubmed
DTHybrid score	0.2046

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.1168
4924	Cytochrome P450 2C8	CYP2C8	0.1007
6016	Cytochrome P450 2C19	CYP2C19	0.0981
1588	Multidrug resistance protein 1	ABCB1	0.091
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0682
4200	Cytochrome P450 1A2	CYP1A2	0.0669
4119	Cytochrome P450 2D6	CYP2D6	0.0652
5852	Type-2 angiotensin II receptor	AGTR2	0.0627
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0585
20	Prostaglandin G/H synthase 1	PTGS1	0.0557
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0522
4118	Cytochrome P450 3A5	CYP3A5	0.0505
587	Serum albumin	ALB	0.0451
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0439
6030	Cytochrome P450 2B6	CYP2B6	0.0424
6107	Cytochrome P450 3A7	CYP3A7	0.0366
862	Multidrug resistance-associated protein 1	ABCC1	0.0351
6013	Cytochrome P450 2E1	CYP2E1	0.0337
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0289
2164	Multidrug resistance-associated protein 4	ABCC4	0.0276
776	Bile salt export pump	ABCB11	0.0275
1729	Solute carrier family 22 member 6	SLC22A6	0.0263
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0253
5718	Cytochrome P450 2A6	CYP2A6	0.0233
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0223
290	Prostaglandin G/H synthase 2	PTGS2	0.0223
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0221
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0219
6024	Cytochrome P450 1A1	CYP1A1	0.0199
1629	Transcription factor AP-1	JUN	0.0198
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.017
118	Organic cation/carnitine transporter 2	SLC22A5	0.0159
136	Estrogen receptor	ESR1	0.0157
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
6142	Solute carrier family 22 member 8	SLC22A8	0.0146
6144	Solute carrier family 22 member 2	SLC22A2	0.0146
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0141
6145	Solute carrier family 22 member 1	SLC22A1	0.0141
6106	Cytochrome P450 2C18	CYP2C18	0.0138
1898	Cytochrome P450 1B1	CYP1B1	0.0138
817	DNA topoisomerase 2-alpha	TOP2A	0.0135
6148	Multidrug resistance-associated protein 7	ABCC10	0.0135
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0129
6141	Sodium/bile acid cotransporter	SLC10A1	0.0128
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0116
6137	Multidrug resistance-associated protein 6	ABCC6	0.0115
6143	Solute carrier family 22 member 7	SLC22A7	0.0115
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0115
477	DNA topoisomerase 4 subunit A	parC	0.0113
886	DNA topoisomerase 4 subunit A	parC	0.0113
6226	DNA topoisomerase 4 subunit A	parC	0.0113
404	DNA gyrase subunit A	gyrA	0.0111
6224	DNA gyrase subunit A	gyrA	0.0111
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0111
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0111
2443	Azurin	azu	0.0108
1024	Solute carrier family 22 member 11	SLC22A11	0.0105
891	Dihydropteroate synthase	folP	0.0103
5359	Dihydropteroate synthase	folP	0.0103
7175	Dihydropteroate synthase	sulI	0.0103
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0101
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0097
492	Histamine H1 receptor	HRH1	0.0094
731	HIV-1 protease	HIV-1 protease	0.0093
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0092
3811	Cytochrome P450 19A1	CYP19A1	0.0087
275	Arachidonate 5-lipoxygenase	ALOX5	0.0086
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0084
6136	Multidrug resistance-associated protein 5	ABCC5	0.0082
24	Thymidylate synthase	TMP1	0.0081
359	Thymidylate synthase	TYMS	0.0081
2626	Thymidylate synthase	thyA	0.0081
2729	Thymidylate synthase	thyA	0.0081
5352	Thymidylate synthase	THYA	0.0081
850	Vasopressin V1b receptor	AVPR1B	0.0081
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.008
614	Progesterone receptor	PGR	0.0078
824	Sodium-dependent serotonin transporter	SLC6A4	0.0075
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0075
122	P2Y purinoceptor 12	P2RY12	0.0075
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0074
185	Vasopressin V1a receptor	AVPR1A	0.0071
6147	Solute carrier family 22 member 3	SLC22A3	0.007
2808	Chloramphenicol acetyltransferase 3	cat3	0.007
322	Vasopressin V2 receptor	AVPR2	0.007
738	Monocarboxylate transporter 1	SLC16A1	0.0069
4604	Liver carboxylesterase 1	CES1	0.0065
468	Cytochrome P450 4A11	CYP4A11	0.0064
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0063
908	Glutathione S-transferase theta-1	GSTT1	0.0063
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0063
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0063
133	Dihydropterate synthase	sulI	0.0063
1757	Myeloperoxidase	MPO	0.0063
3270	Elongation factor G	fusA	0.0062
4116	Dihydropteroate synthetase	Not Available	0.0062
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0059
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0058
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0058
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0058
833	Organic cation/carnitine transporter 1	SLC22A4	0.0058
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0057
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0056
146	Androgen receptor	AR	0.0056
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0055
6146	High affinity copper uptake protein 1	SLC31A1	0.0054
3810	Catechol O-methyltransferase	COMT	0.0054
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0053
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0051
2232	Interleukin-5	IL5	0.0051
1593	Mucin-2	MUC2	0.0051
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0051
904	Glutathione S-transferase P	GSTP1	0.005
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.005
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.005
6163	Copper-transporting ATPase 2	ATP7B	0.005
6165	Copper-transporting ATPase 1	ATP7A	0.005
6031	Cytochrome P450 3A43	CYP3A43	0.0049
260	Cytochrome P450 51	ERG11	0.0048
761	Cytochrome P450 51	ERG11	0.0048
3163	Cytochrome P450 51	cyp51	0.0048
5626	Nucleoside diphosphate kinase B	NME2	0.0048
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0048
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0047
777	Tumor necrosis factor	TNF	0.0047
3947	Xanthine dehydrogenase/oxidase	XDH	0.0046
6085	Fatty acid-binding protein, intestinal	FABP2	0.0046
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0046
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0046
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
896	Glutathione S-transferase Mu 1	GSTM1	0.0045
407	Vascular endothelial growth factor receptor 2	KDR	0.0044
713	Sodium-dependent dopamine transporter	SLC6A3	0.0044
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0044
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0044
49	Endothelin B receptor	EDNRB	0.0044
3941	Amine oxidase [flavin-containing] A	MAOA	0.0043
504	Mast/stem cell growth factor receptor	KIT	0.0043
1123	Eosinophil cationic protein	RNASE3	0.0042
161	Tubulin beta chain	TUBB	0.0042
312	Tubulin beta chain	TUB2	0.0042
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0041
578	Endothelin-1 receptor	EDNRA	0.0041
3939	Amine oxidase [flavin-containing] B	MAOB	0.0041
590	5-hydroxytryptamine 2C receptor	HTR2C	0.004
357	Carbonic anhydrase 2	CA2	0.004
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.004
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.004
831	D(2) dopamine receptor	DRD2	0.004
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.004
5294	Nucleoside diphosphate kinase A	NME1	0.0039
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0039
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0039
465	Calmodulin	CALM1	0.0039
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0039
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0038
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0038
5923	Microtubule-associated protein tau	MAPT	0.0038
5924	Microtubule-associated protein 4	MAP4	0.0038
365	Dihydrofolate reductase	DHFR	0.0038
2381	Dihydrofolate reductase	DFR1	0.0038
2833	Dihydrofolate reductase	Not Available	0.0038
2931	Dihydrofolate reductase	folA	0.0038
3544	Dihydrofolate reductase	folA	0.0038
3682	Dihydrofolate reductase	folA	0.0038
6642	Dihydrofolate reductase	folA	0.0038
6756	Dihydrofolate reductase	dfrA	0.0038
29	Tubulin beta-1 chain	TUBB1	0.0038
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0038
26	Vascular endothelial growth factor receptor 3	FLT4	0.0038
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0038
273	Apoptosis regulator Bcl-2	BCL2	0.0037
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0037
737	Mineralocorticoid receptor	NR3C2	0.0037
130	Prostacyclin synthase	PTGIS	0.0037
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0036
295	Carbonic anhydrase 1	CA1	0.0036
32	Vascular endothelial growth factor receptor 1	FLT1	0.0036
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0036
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0036
1275	Estrogen sulfotransferase	SULT1E1	0.0036
4120	NADPH--cytochrome P450 reductase	POR	0.0036
558	Solute carrier family 12 member 1	SLC12A1	0.0035
1852	Microtubule-associated protein 2	MAP2	0.0035
33	Cystine/glutamate transporter	SLC7A11	0.0035
461	Glycine receptor subunit alpha-3	GLRA3	0.0035
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0035
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0035
592	Carbonic anhydrase 4	CA4	0.0035
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0034
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0034
165	FL cytokine receptor	FLT3	0.0033
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0033
6149	Solute carrier family 22 member 10	SLC22A10	0.0033
847	Mu-type opioid receptor	OPRM1	0.0033
696	Kappa-type opioid receptor	OPRK1	0.0033
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0033
1650	Heme carrier protein 1	SLC46A1	0.0033
556	Alpha-1A adrenergic receptor	ADRA1A	0.0032
811	Translocator protein	TSPO	0.0032
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0032
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0032
632	Alpha-1B adrenergic receptor	ADRA1B	0.0031
6220	Aryl hydrocarbon receptor	AHR	0.0031
467	Delta-type opioid receptor	OPRD1	0.0031
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0031
131	Synaptic vesicular amine transporter	SLC18A2	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
766	Beta-2 adrenergic receptor	ADRB2	0.0031
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0031
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0031
318	Alpha-2A adrenergic receptor	ADRA2A	0.003
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.003
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0029
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0028
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0028
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0028
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0028
4192	DNA topoisomerase 2-beta	TOP2B	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
6102	Arylamine N-acetyltransferase 2	NAT2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
1630	Integrin beta-2	ITGB2	0.0027
1569	G1/S-specific cyclin-D1	CCND1	0.0027
23	D(1A) dopamine receptor	DRD1	0.0027
54	Prothrombin	F2	0.0026
571	Melatonin receptor type 1A	MTNR1A	0.0026
362	Melatonin receptor type 1B	MTNR1B	0.0026
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0026
6126	Carbonic anhydrase 7	CA7	0.0026
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0026
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0025
427	Substance-P receptor	TACR1	0.0025
1760	Aminopeptidase N	ANPEP	0.0025
6843	Aminopeptidase N	pepN	0.0025
869	Estrogen receptor beta	ESR2	0.0025
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0025
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0025
1541	Metalloproteinase	mmp20	0.0025
117	Sterol O-acyltransferase 1	SOAT1	0.0025
482	Glycine receptor subunit alpha-1	GLRA1	0.0024
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0024
183	Vascular endothelial growth factor A	VEGFA	0.0024
6211	Tubulin epsilon chain	TUBE1	0.0024
6210	Tubulin delta chain	TUBD1	0.0024
6212	Tubulin gamma-1 chain	TUBG1	0.0024
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0024
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0024
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0024
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0024
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0024
380	Cytochrome P450 17A1	CYP17A1	0.0024
4122	Histone deacetylase 2	HDAC2	0.0023
459	Retinoic acid receptor RXR-alpha	RXRA	0.0023
94	5-hydroxytryptamine 4 receptor	HTR4	0.0023
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0023
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0023
6182	Cytochrome P450 2J2	CYP2J2	0.0023
3923	Cholinesterase	BCHE	0.0023
489	Monocarboxylate transporter 2	SLC16A7	0.0023
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0022
6044	Serum paraoxonase/lactonase 3	PON3	0.0022
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0021
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0021
780	Retinoic acid receptor RXR-gamma	RXRG	0.0021
4203	Histamine N-methyltransferase	HNMT	0.0021
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0021
4773	Deoxycytidine kinase	DCK	0.0021
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0021
6167	Organic solute transporter subunit beta	OSTB	0.002
6166	Organic solute transporter subunit alpha	OSTA	0.002
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.002
84	Nuclear receptor 0B1	NR0B1	0.002
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.002
3868	Calcineurin subunit B isoform 2	PPP3R2	0.002
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.002
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.002
572	Integrin alpha-L	ITGAL	0.002
153	Dopamine beta-hydroxylase	DBH	0.002
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.002
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.002
3587	Gastrotropin	FABP6	0.002
1192	Sulfotransferase 1A1	SULT1A1	0.002
921	Glutamate receptor 2	GRIA2	0.002
2539	Tubulin alpha-1 chain	TUBA4A	0.002
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0019
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0019
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0019
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0019
6837	Serine/threonine-protein kinase 17B	STK17B	0.0019
88	Retinoic acid receptor RXR-beta	RXRB	0.0019
3639	Thymidine phosphorylase	deoA	0.0019
3936	Thymidine phosphorylase	TYMP	0.0019
7	Nitric oxide synthase, inducible	NOS2	0.0018
789	Alpha-1D adrenergic receptor	ADRA1D	0.0018
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0018
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0018
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0018
1176	Mitogen-activated protein kinase 1	MAPK1	0.0018
3809	Estrogen-related receptor gamma	ESRRG	0.0017
2449	Tubulin alpha-3 chain	TUBA1A	0.0017
6218	Pannexin-1	PANX1	0.0017
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0017
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0017
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
1313	Lactoylglutathione lyase	GLO1	0.0017
751	Potassium channel subfamily K member 6	KCNK6	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0017
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0017
702	UMP-CMP kinase	CMPK1	0.0016
6014	Cytochrome P450 2A13	CYP2A13	0.0016
1648	Elastin	ELN	0.0015
172	Potassium channel subfamily K member 1	KCNK1	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0015
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0015
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6042	Prostaglandin reductase 2	PTGR2	0.0015
1656	CYP2B protein	CYP2B	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0015
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0015
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0015
2599	Tyrosine-protein kinase HCK	HCK	0.0015
3611	Cytidine deaminase	cdd	0.0014
3707	Cytidine deaminase	cdd	0.0014
4211	Cytidine deaminase	CDA	0.0014
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0014
1010	Cytochrome P450 51A1	CYP51A1	0.0014
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0014
756	Sex hormone-binding globulin	SHBG	0.0014
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0014
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0014
1353	DNA topoisomerase 1	TOP1	0.0014
3552	DNA topoisomerase 1	topA	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
629	Alpha-2B adrenergic receptor	ADRA2B	0.0014
6043	Putative G-protein coupled receptor 44	GPR44	0.0014
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0014
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0014
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0014
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0014
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0014
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0014
469	Annexin A1	ANXA1	0.0014
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0014
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0014
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0014
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0014
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0014
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0014
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0013
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0013
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
284	DNA-directed RNA polymerase beta chain	rpoB	0.0013
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0013
844	Epidermal growth factor receptor	EGFR	0.0013
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0013
823	Fibroblast growth factor receptor 2	FGFR2	0.0013
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0013
6103	Arylamine N-acetyltransferase 1	NAT1	0.0013
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0012
124	Histamine H2 receptor	HRH2	0.0012
193	Beta-1 adrenergic receptor	ADRB1	0.0012
518	Peroxidase/catalase T	katG	0.0012
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0012
474	Acetylcholinesterase	ACHE	0.0011
164	Histamine H4 receptor	HRH4	0.0011
5818	Folate receptor alpha	FOLR1	0.0011
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0011
1618	High affinity nerve growth factor receptor	NTRK1	0.0011
340	Apoptotic protease-activating factor 1	APAF1	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
638	D(3) dopamine receptor	DRD3	0.0011
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0011
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0011
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0011
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0011
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0011
106	Cannabinoid receptor 2	CNR2	0.0011
432	D(4) dopamine receptor	DRD4	0.0011
6168	Solute carrier family 22 member 16	SLC22A16	0.0011
2391	Ferrochelatase	hemH	0.0011
6502	Ferrochelatase	DKFZp686P18130	0.0011
1591	Ferrochelatase, mitochondrial	FECH	0.0011
517	Alcohol dehydrogenase 1C	ADH1C	0.0011
6174	50S ribosomal protein L32	rpmF	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
1196	Complement decay-accelerating factor	CD55	0.001
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.001
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.001
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.001
68	Cannabinoid receptor 1	CNR1	0.001
563	Thyroid peroxidase	TPO	0.001
6138	Multidrug resistance protein 3	ABCB4	0.001
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.001
293	Gamma-glutamyl hydrolase	GGH	0.001
952	Dipeptidyl peptidase 4	DPP4	0.001
825	Arsenical pump-driving ATPase	ASNA1	0.001
3435	Arsenical pump-driving ATPase	arsA	0.001
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.001
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.001
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.001
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.001
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.001
733	Activin receptor type 1B	ACVR1B	0.001
154	AFG3-like protein 2	AFG3L2	0.001
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.001
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.001
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.001
395	ALK tyrosine kinase receptor	Not Available	0.001
16	Adenosine A1 receptor	ADORA1	0.001
1178	Adenosine A2a receptor	ADORA2A	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.001
634	Squalene monooxygenase	SQLE	0.0009
7196	Squalene monooxygenase	ERG1	0.0009
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0009
716	5-hydroxytryptamine 7 receptor	HTR7	0.0009
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0009
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0009
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0009
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0009
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0009
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0009
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0009
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0009
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0009
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0009
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0009
6559	Cytochrome c oxidase subunit 2	ctaC	0.0009
6669	Cytochrome c oxidase subunit 2	ctaC	0.0009
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0009
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0009
6558	Cytochrome c oxidase subunit 1	ctaD	0.0009
291	Nitric-oxide synthase, endothelial	NOS3	0.0009
1341	Histamine H3 receptor	HRH3	0.0009
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0009
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0009
292	Activin receptor type-1	ACVR1	0.0009
849	Activated CDC42 kinase 1	TNK2	0.0009
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0009
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0009
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0009
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0009
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0009
297	Adenylate cyclase type 1	ADCY1	0.0009
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0009
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0008
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0008
2540	Choloylglycine hydrolase	cbh	0.0008
3808	Dihydropteroate synthase 2	folP2	0.0008
871	Glucocorticoid receptor	NR3C1	0.0008
3601	Dihydropteroate synthase 1	folP1	0.0008
3807	Dihydropteroate synthase 1	folP1	0.0008
2417	Chloramphenicol acetyltransferase	cat	0.0008
3278	Chloramphenicol acetyltransferase	cat	0.0008
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0008
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0008
2810	Dr hemagglutinin structural subunit	draA	0.0008
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0008
484	Tyrosine-protein kinase ABL2	ABL2	0.0008
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0008
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0008
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0008
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0008
6501	Fatty acid-binding protein, liver	FABP1	0.0008
581	Cytochrome P450 2R1	CYP2R1	0.0008
76	Nitric-oxide synthase, brain	NOS1	0.0008
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0008
3830	Calreticulin	CALR	0.0008
1992	Vitamin D-binding protein	GC	0.0007
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0007
4034	Glutaredoxin-1	GLRX	0.0007
910	Epididymal secretory glutathione peroxidase	GPX5	0.0007
903	Glutathione S-transferase A5	GSTA5	0.0007
4037	Hypothetical protein	GPX1	0.0007
4297	Hypothetical protein	SP_1951	0.0007
4521	Hypothetical protein	BC_2969	0.0007
4540	Hypothetical protein	TM_1070	0.0007
4555	Hypothetical protein	MT1739	0.0007
4569	Hypothetical protein	mshD	0.0007
4578	Hypothetical protein	PA3270	0.0007
4747	Hypothetical protein	PA3967	0.0007
5177	Hypothetical protein	TM_0096	0.0007
5194	Hypothetical protein	PA1204	0.0007
5240	Hypothetical protein	Rv2991	0.0007
5370	Hypothetical protein	TM_1158	0.0007
5710	Hypothetical protein	Tb927.5.1360	0.0007
1928	Leukotriene C4 synthase	LTC4S	0.0007
4029	Microsomal glutathione S-transferase 3	MGST3	0.0007
4032	Microsomal glutathione S-transferase 1	MGST1	0.0007
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0007
4040	Glutathione peroxidase 7	GPX7	0.0007
907	Glutathione peroxidase 2	GPX2	0.0007
4038	Glutathione peroxidase 4	GPX4	0.0007
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0007
906	Glutathione peroxidase 1	GPX1	0.0007
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0007
4035	Glutathione S-transferase Mu 5	GSTM5	0.0007
4036	Glutathione peroxidase 6	GPX6	0.0007
900	Glutathione S-transferase A4	GSTA4	0.0007
911	Glutathione peroxidase 3	GPX3	0.0007
4042	Glutathione transferase omega-2	GSTO2	0.0007
4033	S-formylglutathione hydrolase	ESD	0.0007
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0007
740	Argininosuccinate synthase	ASS1	0.0007
865	Argininosuccinate synthase	ASS1	0.0007
2680	Argininosuccinate synthase	argG	0.0007
3194	Argininosuccinate synthase	argG	0.0007
319	Opioid receptor, sigma 1	OPRS1	0.0007
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0007
4948	Cytochrome c-553	Not Available	0.0007
4923	Cytochrome c3	DvMF_2499	0.0007
4945	Cytochrome c3	Not Available	0.0007
4949	Cytochrome c3	DVU_3171	0.0007
4968	Cytochrome c3	cytc3	0.0007
4997	Cytochrome c3	SO_2727	0.0007
5219	Cytochrome c3	cyd	0.0007
4902	Nine-heme cytochrome c	Ddes_2038	0.0007
3189	High-molecular-weight cytochrome c	hmcA	0.0007
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0007
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0007
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0007
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0007
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0007
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0007
6021	Adenosine kinase	ADK	0.0007
661	ADP/ATP translocase 1	SLC25A4	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0007
976	Platelet glycoprotein IX	GP9	0.0007
4103	Proteasome subunit beta type 2	PSMB2	0.0007
4102	Proteasome subunit beta type 5	PSMB5	0.0007
4101	Proteasome subunit beta type 1	PSMB1	0.0007
373	Transthyretin	TTR	0.0007
1374	Natriuretic peptides B	NPPB	0.0007
1827	Gap junction alpha-1 protein	GJA1	0.0007
1908	Vascular cell adhesion protein 1	VCAM1	0.0007
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0007
6020	Aldehyde oxidase	AOX1	0.0007
898	Glutathione S-transferase A3	GSTA3	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
897	Glutathione S-transferase kappa 1	GSTK1	0.0007
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0007
4217	Telomerase reverse transcriptase	TERT	0.0007
6500	Phospholipase A2	PLA2G1B	0.0007
909	Maleylacetoacetate isomerase	GSTZ1	0.0007
814	Ryanodine receptor 1	RYR1	0.0007
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0006
899	Glutathione S-transferase Mu 3	GSTM3	0.0006
905	Glutathione transferase omega-1	GSTO1	0.0006
239	Coagulation factor X	F10	0.0006
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0006
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0006
4041	Microsomal glutathione S-transferase 2	MGST2	0.0006
4386	Hemoglobin-like protein HbN	glbN	0.0006
251	Alcohol dehydrogenase 1A	ADH1A	0.0006
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0006
174	Sigma 1-type opioid receptor	SIGMAR1	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
4225	Uridine phosphorylase 1	UPP1	0.0006
705	Glutamate receptor 1	GRIA1	0.0006
6048	Troponin C, skeletal muscle	TNNC2	0.0006
2165	Glutathione S-transferase Mu 2	GSTM2	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0006
719	Retinoic acid receptor responder protein 1	RARRES1	0.0006
378	Alpha-2C adrenergic receptor	ADRA2C	0.0006
770	Retinoic acid-induced protein 3	GPRC5A	0.0006
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0006
820	Glycine receptor subunit alpha-2	GLRA2	0.0006
207	Glutathione synthetase	GSS	0.0006
5269	Glutathione synthetase	gshB	0.0006
268	Adenosine A2b receptor	ADORA2B	0.0006
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
828	Phenylalanine-4-hydroxylase	PAH	0.0006
3109	Phenylalanine-4-hydroxylase	phhA	0.0006
163	D(1B) dopamine receptor	DRD5	0.0006
3221	Cytochrome c4	cc4	0.0006
2021	Thrombomodulin	THBD	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
901	Glutathione S-transferase Mu 4	GSTM4	0.0005
444	Alcohol dehydrogenase 1B	ADH1B	0.0005
856	Vitamin D3 receptor	VDR	0.0005
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0005
5798	Mitogen-activated protein kinase 11	MAPK11	0.0005
2320	Thymidine kinase, cytosolic	TK1	0.0005
267	Plasminogen activator inhibitor 1	SERPINE1	0.0005
569	Retinal dehydrogenase 2	ALDH1A2	0.0005
1864	RET proto-oncogene	RET	0.0005
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0005
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0005
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0005
3932	Glutathione S-transferase A2	GSTA2	0.0005
4031	Glutathione S-transferase A1	GSTA1	0.0005
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0005
714	Glutathione reductase, mitochondrial	GSR	0.0005
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
611	Retinal dehydrogenase 1	ALDH1A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0005
1507	Cytochrome c	CYCS	0.0005
1268	Neuropeptide S receptor	NPSR1	0.0005
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0005
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0005
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0005
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0005
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0005
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0005
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0005
1050	Bile salt sulfotransferase	SULT2A1	0.0005
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0005
6221	Steroid hormone receptor ERR1	ESRRA	0.0005
5934	Cytochrome P450 26A1	CYP26A1	0.0005
1039	Histone deacetylase 9	HDAC9	0.0004
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0004
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0004
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0004
6073	Potassium channel subfamily K member 9	KCNK9	0.0004
6072	Potassium channel subfamily K member 3	KCNK3	0.0004
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0004
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
3937	Fatty-acid amide hydrolase	FAAH	0.0004
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0004
936	Ephrin type-A receptor 2	EPHA2	0.0004
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0004
5787	Angiopoietin-1 receptor	TEK	0.0004
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0004
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0004
3957	Adenosine deaminase	ADA	0.0004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0004
162	Retinoic acid receptor gamma-1	RARG	0.0004
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0004
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0004
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0004
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0004
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0004
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0003
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0003
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0003
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0003
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0003
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0003
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0003
2207	Rhodopsin	RHO	0.0003
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0003
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0003
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0003
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0003
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0003
4954	Soluble cytochrome b558	Not Available	0.0002
4916	Cyanoglobin	glbN	0.0002
4934	Cytochrome c-551	nirM	0.0002
5218	Cytochrome c-551	nirM	0.0002
4947	Bacterial hemoglobin	vhb	0.0002
4915	Cytochrome c-550	psbV	0.0002
4959	Cytochrome c-550	psbV	0.0002
5216	Cytochrome c-550	psbV	0.0002
4925	Cytochrome c-type protein SHP	shp	0.0002
4998	Hemoglobin-like protein yjbI	yjbI	0.0002
4905	Cytochrome c2	Not Available	0.0002
4939	Cytochrome c2	cycA	0.0002
4964	Cytochrome c2	cycA	0.0002
4979	Cytochrome c2	cycA	0.0002
6673	Cytochrome c2	cycA	0.0002
5000	HemO	hemO	0.0002
4975	Cytochrome c-556	RPA3973	0.0002
4984	Neuroglobin	NGB	0.0002
4943	Cytochrome c6	petJ	0.0002
4910	Cytoglobin	CYGB	0.0002
4907	Cytochrome c-L	moxG	0.0002
6865	Cytochrome c-L	moxG	0.0002
4981	Iron-starvation protein PigA	pigA	0.0002
4971	Nonaheme cytochrome c	hmcA	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0002
4909	CooA protein	cooA	0.0002
4994	Hemoglobin-like protein HbO	glbO	0.0002
4935	Cytochrome c-554	cycA1	0.0002
644	Heme oxygenase 2	HMOX2	0.0002
4982	Heme oxygenase 2	pbsA2	0.0002
4942	Diheme cytochrome c napB	napB	0.0002
3116	Bacterioferritin	bfr	0.0002
4906	Bacterioferritin	bfr	0.0002
4965	Bacterioferritin	bfr	0.0002
4922	Cytochrome c, putative	SO_4144	0.0002
4764	Cytochrome P450 165C4	CYP165C4	0.0002
4937	Cytochrome oxidase subunit II	rcoxA	0.0002
4989	Cytochrome c551 peroxidase	ccp	0.0002
5222	Cytochrome c551 peroxidase	ccpA	0.0002
4961	Hemophore HasA	hasA	0.0002
4976	Apocytochrome f	petA	0.0002
6407	Apocytochrome f	petA	0.0002
4904	Cytochrome c family protein	GSU1996	0.0002
4903	Methyl-accepting chemotaxis protein	Tar4	0.0002
4999	Cytochrome P450 165B3	CYP165B3	0.0002
4960	Putative cytochrome P450-family protein	SCO7417	0.0002
4931	Cytochrome P450 167A1	CYP167A1	0.0002
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0002
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0002
4993	Hydroxylamine oxidoreductase	hao1	0.0002
4972	P450cin	cinA	0.0002
3093	Catalase HPII	katE	0.0002
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0002
4952	Catalase/peroxidase	katA	0.0002
4920	Peroxidase/catalase	katG	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
4990	PpcA	ppcA	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
605	Fumarate reductase flavoprotein subunit	frdA	0.0001
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0001
3673	Fumarate reductase flavoprotein subunit	fccA	0.0001
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0001
6549	Fumarate reductase flavoprotein subunit	frdA	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001
2298	Cytochrome P450-cam	camC	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00876 - Eprosartan

Targets

Enzymes

Transporters

Predictions