DT-Web

DB03191 - 3-Oxiran-2ylalanine


Identification
Name 3-Oxiran-2ylalanine
Accession Number DB03191 (EXPT02037)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 131.1299
Groups experimental
Monoisotopic Weight 131.058243159
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


S-adenosylmethionine synthetase isoform type-1
Name S-adenosylmethionine synthetase isoform type-1
Gene Name MAT1A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7912

Predictions


Id Partner name Gene Name Score
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0718
330 Spermidine synthase SRM 0.0471
3038 Spermidine synthase speE 0.0471
411 Glycine N-methyltransferase GNMT 0.0378
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0375
358 Cystathionine beta-synthase CBS 0.0348
3810 Catechol O-methyltransferase COMT 0.0254
317 Methionine-R-sulfoxide reductase SEPX1 0.0249
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0249
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0249
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0249
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0249
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0249
191 Peptide methionine sulfoxide reductase MSRA 0.0217
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0205
840 Methionine synthase reductase, mitochondrial MTRR 0.0174
809 Methionine synthase MTR 0.0163
2935 Methionine synthase metH 0.0163
6013 Cytochrome P450 2E1 CYP2E1 0.0158
2795 Methionine aminopeptidase 2 METAP2 0.0144
3917 Methylenetetrahydrofolate reductase MTHFR 0.0136
6151 Monocarboxylate transporter 10 SLC16A10 0.0117
5293 Shikimate kinase 2 aroL 0.0044
5266 Activator of hgdC 0.0044
5287 Signaling protein Not Available 0.0044
5288 Shikimate kinase aroK 0.0044
5304 UPF0166 protein TM_0021 TM_0021 0.0044
5292 Putative partitioning protein TT_C1605 0.0044
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0044
3199 Phosphopantetheine adenylyltransferase coaD 0.0044
3543 Phosphopantetheine adenylyltransferase coaD 0.0044
3567 Phosphopantetheine adenylyltransferase coaD 0.0044
5289 Phosphopantetheine adenylyltransferase coaD 0.0044
5283 D-alanine--D-alanine ligase B ddlB 0.0044
5281 Plasmid segregation protein parM parM 0.0044
5276 Chromosomal replication initiator protein dnaA dnaA 0.0044
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0044
5259 Transcriptional regulator ntrC1 0.0044
6699 Transcriptional regulator Cgl2612 0.0044
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0044
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0044
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0044
5291 Glycogen synthase 1 glgA1 0.0044
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0044
2874 Nitrogenase iron protein 1 nifH1 0.0044
4346 Polynucleotide kinase pseT 0.0044
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0044
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0044
5308 Preprotein translocase secA 1 subunit secA1 0.0044
5285 Kinesin heavy chain KIF5B 0.0044
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0044
5299 D-alanine--D-alanine ligase ddl 0.0044
6598 D-alanine--D-alanine ligase ddl 0.0044
5284 Large T antigen Not Available 0.0044
5315 Chaperone protein htpG htpG 0.0044
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0044
5261 Phosphoribosylformylglycinamidine synthase purL 0.0044
5277 Preprotein translocase subunit secA secA 0.0044
5264 DNA replication protein REP 0.0044
3175 Glutamate--cysteine ligase gshA 0.0037
3426 Glutamine synthetase glnA 0.0036
3987 Glutamine synthetase GLUL 0.0036
4106 Guanylate kinase GUK1 0.0036
4516 Guanylate kinase gmk 0.0036
413 Amidophosphoribosyltransferase PPAT 0.0036
2515 Amidophosphoribosyltransferase purF 0.0036
3714 Amidophosphoribosyltransferase purF 0.0036
4837 Cag-alfa cag-alfa 0.0036
6277 Heat shock cognate 71 kDa protein HSPA8 0.0036
4774 NTPase P4 Not Available 0.0036
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0036
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0036
5302 TrwB trwB 0.0036
5265 FtsH ftsH 0.0036
4839 DNA polymerase III subunit tau dnaX 0.0036
5646 Galactokinase GALK1 0.0036
4838 PMS1 protein homolog 2 PMS2 0.0036
5189 Trimethylamine dehydrogenase tmd 0.0036
2270 Dephospho-CoA kinase coaE 0.0036
2284 Adenylate kinase adk 0.0036
2296 Adenylate kinase adk 0.0036
2311 Adenylate kinase adk 0.0036
2312 Adenylate kinase Not Available 0.0036
3470 Hypothetical protein MG245 homolog MPN_348 0.0036
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0036
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0036
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0036
2683 Mono-ADP-ribosyltransferase C3 C3 0.0034
340 Apoptotic protease-activating factor 1 APAF1 0.0033
2390 Nonsecretory ribonuclease RNASE2 0.0033
5312 Kinesin-like protein KIF1A KIF1A 0.0033
5300 Antigen peptide transporter 1 TAP1 0.0032
2922 Glycerol kinase glpK 0.0032
5271 Focal adhesion kinase 1 PTK2 0.0032
2282 Protein recA recA 0.0031
2315 Protein recA recA 0.0031
2332 Protein recA recA 0.0031
5263 Protein recA recA 0.0031
408 Riboflavin kinase RFK 0.0031
2615 Chemotaxis protein cheA cheA 0.003
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.003
2371 Pantothenate kinase coaA 0.003
2892 Acetylglutamate kinase argB 0.003
3550 Acetylglutamate kinase argB 0.003
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.003
1881 Hexokinase-1 HK1 0.003
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.003
3669 Ribokinase rbsK 0.003
825 Arsenical pump-driving ATPase ASNA1 0.003
3435 Arsenical pump-driving ATPase arsA 0.003
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.003
788 Creatine kinase M-type CKM 0.003
2727 S-adenosylmethionine synthetase metK 0.0029
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0029
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0028
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0028
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0028
2697 Uridine-cytidine kinase 2 UCK2 0.0027
2334 Dethiobiotin synthetase bioD 0.0027
6555 Dethiobiotin synthetase bioD 0.0027
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0026
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0026
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0026
207 Glutathione synthetase GSS 0.0026
5269 Glutathione synthetase gshB 0.0026
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0026
48 Pyridoxal kinase PDXK 0.0026
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0025
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0025
702 UMP-CMP kinase CMPK1 0.0025
2091 Endoplasmin HSP90B1 0.0025
2251 Thymidylate kinase tmk 0.0025
2254 Thymidylate kinase DTYMK 0.0025
3522 Thymidylate kinase tmk 0.0025
6395 Myosin-14 MYH14 0.0025
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0024
1422 Serine/threonine-protein kinase 6 AURKA 0.0024
3379 Kinesin-like protein KIF11 KIF11 0.0023
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0023
3822 Actin, alpha skeletal muscle ACTA1 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
509 Thymidine kinase TK 0.0022
570 Thymidine kinase TK 0.0022
2559 Thymidine kinase TK 0.0022
3430 Thymidine kinase tdk 0.0022
3518 Thymidine kinase TK 0.0022
5301 Thymidine kinase tdk 0.0022
5771 Thymidine kinase ORF36 0.0022
7009 Thymidine kinase ORF36 0.0022
5294 Nucleoside diphosphate kinase A NME1 0.0021
1721 Glycogen synthase kinase-3 beta GSK3B 0.0021
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.002
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.002
4773 Deoxycytidine kinase DCK 0.002
5682 Ribonuclease pancreatic RNASE1 0.002
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0018
↑