DT-Web

DB01783 - Pantothenic acid


Identification
Name Pantothenic acid
Accession Number DB01783 (EXPT02501)
Type small molecule
Description Pantothenic acid, also called pantothenate or vitamin B5 (a B vitamin), is a water-soluble vitamin discovered by Roger J. Williams in 1919. For many animals, pantothenic acid is an essential nutrient. Animals require pantothenic acid to synthesize coenzyme-A (CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats. Pantothenic acid is the amide between pantoic acid and ?-alanine. Small quantities of pantothenic acid are found in nearly every food, with high amounts in whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt. It is commonly found as its alcohol analog, the provitamin panthenol, and as calcium pantothenate. Pantothenic acid is an ingredient in some hair and skin care products. Only the dextrorotatory (D) isomer of pantothenic acid possesses biologic activity. The levorotatory (L) form may antagonize the effects of the dextrorotatory isomer. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 219.235
Groups nutraceutical
Monoisotopic Weight 219.110672659
Pharmacology
Indication Studied for the treatment of many uses such as treatment of testicular torsion, diabetic ulceration, wound healing, acne, obesity, diabetic peripheral polyneuropathy. It has also been investigated for its hypolipidemic effects and as cholesterol lowering agent.
Mechanism of action Pantothenic acid is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.
Absorption When found in foods, most pantothenic acid is in the form of CoA or acyl carrier protein (ACP). For the intestinal cells to absorb this vitamin, it must be converted into free pantothenic acid. Within the lumen of the intestine, CoA and ACP are hydrolyzed into 4'-phosphopantetheine. The 4'-phosphopantetheine is then dephosphorylated into pantetheine. Pantetheinase, an intestinal enzyme, then hydrolyzes pantetheine into free pantothenic acid. Free pantothenic acid is absorbed into intestinal cells via a saturable, sodium-dependent active transport system. At high levels of intake, when this mechanism is saturated, some pantothenic acid may also be absorbed via passive diffusion. As intake increases 10-fold, however, absorption rate decreases to 10%. [Wikipedia]
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity No Tolerable Upper Level Intake (UL) has been established for the vitamin.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Pantothenate kinase
Name Pantothenate kinase
Gene Name coaA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5278

Predictions


Id Partner name Gene Name Score
5646 Galactokinase GALK1 0.0152
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0152
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0152
5302 TrwB trwB 0.0152
5265 FtsH ftsH 0.0152
5312 Kinesin-like protein KIF1A KIF1A 0.014
4564 YvbK protein yvbK 0.0137
4566 Acyl-CoA hydrolase BC_2038 0.0137
4572 Acyl-CoA hydrolase BH0798 0.0137
4576 Aac(6')-Ii protein aac(6')-Ii 0.0137
4567 Putative acyl-CoA thioester hydrolase HI0827 HI_0827 0.0137
4037 Hypothetical protein GPX1 0.0137
4297 Hypothetical protein SP_1951 0.0137
4521 Hypothetical protein BC_2969 0.0137
4540 Hypothetical protein TM_1070 0.0137
4555 Hypothetical protein MT1739 0.0137
4569 Hypothetical protein mshD 0.0137
4578 Hypothetical protein PA3270 0.0137
4747 Hypothetical protein PA3967 0.0137
5177 Hypothetical protein TM_0096 0.0137
5194 Hypothetical protein PA1204 0.0137
5240 Hypothetical protein Rv2991 0.0137
5370 Hypothetical protein TM_1158 0.0137
5710 Hypothetical protein Tb927.5.1360 0.0137
4577 4'-phosphopantetheinyl transferase sfp sfp 0.0137
2528 Fatty acid metabolism regulator protein fadR 0.0137
6740 Fatty acid metabolism regulator protein fadR 0.0137
4579 Serine acetyltransferase cysE 0.0137
6807 Serine acetyltransferase cysE 0.0137
2892 Acetylglutamate kinase argB 0.0133
3550 Acetylglutamate kinase argB 0.0133
825 Arsenical pump-driving ATPase ASNA1 0.0133
3435 Arsenical pump-driving ATPase arsA 0.0133
2615 Chemotaxis protein cheA cheA 0.0133
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0133
1881 Hexokinase-1 HK1 0.0133
2727 S-adenosylmethionine synthetase metK 0.0127
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0124
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0122
5643 General secretion pathway protein E epsE 0.0122
5642 Chaperone clpB clpB 0.0122
5644 Sensor protein phoQ phoQ 0.0122
5641 Rod shape-determining protein MreB TM_0588 0.0122
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0122
5645 DNA topoisomerase 4 subunit B parE 0.0122
6227 DNA topoisomerase 4 subunit B parE 0.0122
5649 Potassium-transporting ATPase B chain kdpB 0.0122
3794 Osmolarity sensor protein envZ envZ 0.0122
3317 Holo-[acyl-carrier-protein] synthase acpS 0.012
4381 Holo-[acyl-carrier-protein] synthase acpS 0.012
3560 Gentamicin 3'-acetyltransferase aacC1 0.0119
4563 Acetyl transferase rimL 0.0119
4565 Aminoglycoside 6'-N-acetyltransferase aac(6')-Iy 0.0119
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0119
4574 PROBABLE NAPHTHOATE SYNTHASE MENB menB 0.0119
2396 Formyl-coenzyme A transferase frc 0.0119
3457 Formyl-coenzyme A transferase frc 0.0119
3729 Citrate synthase gltA 0.0119
4575 Citrate synthase cit 0.0119
4580 Citrate synthase gltA 0.0119
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0119
3489 Acetyl-coenzyme A synthetase acs 0.0119
3024 Crotonobetainyl-CoA:carnitine CoA-transferase caiB 0.0119
2560 Galactoside O-acetyltransferase lacA 0.011
3199 Phosphopantetheine adenylyltransferase coaD 0.011
3543 Phosphopantetheine adenylyltransferase coaD 0.011
3567 Phosphopantetheine adenylyltransferase coaD 0.011
5289 Phosphopantetheine adenylyltransferase coaD 0.011
2285 Streptogramin A acetyltransferase vatD 0.011
2251 Thymidylate kinase tmk 0.011
2254 Thymidylate kinase DTYMK 0.011
3522 Thymidylate kinase tmk 0.011
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.011
2377 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Not Available 0.011
2248 Malate synthase G glcB 0.011
3190 Malate synthase G glcB 0.011
3178 Formate acetyltransferase 1 pflB 0.011
4573 Histone acetyltransferase PCAF KAT2B 0.011
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0106
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0106
740 Argininosuccinate synthase ASS1 0.0106
865 Argininosuccinate synthase ASS1 0.0106
2680 Argininosuccinate synthase argG 0.0106
3194 Argininosuccinate synthase argG 0.0106
2852 DNA mismatch repair protein mutL mutL 0.0106
4751 Mitogen-activated protein kinase 12 MAPK12 0.0106
2397 Dihydroxyacetone kinase dhaK 0.0106
207 Glutathione synthetase GSS 0.0105
5269 Glutathione synthetase gshB 0.0105
4404 FcbC1 protein fcbC 0.0104
3822 Actin, alpha skeletal muscle ACTA1 0.0103
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0103
551 Carnitine O-acetyltransferase CRAT 0.01
2376 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD 0.0099
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0098
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0098
3231 Death-associated protein kinase 1 DAPK1 0.0098
1721 Glycogen synthase kinase-3 beta GSK3B 0.0095
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0094
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0094
615 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0091
3138 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0091
4568 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0091
6370 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0091
2596 Acetyl-CoA acetyltransferase phbA 0.009
887 DNA gyrase subunit B gyrB 0.0089
4150 DNA gyrase subunit B gyrB 0.0089
6225 DNA gyrase subunit B gyrB 0.0089
4388 Aminoglycoside 2'-N-acetyltransferase aac 0.0088
936 Ephrin type-A receptor 2 EPHA2 0.0088
958 Insulin-like growth factor 1 receptor IGF1R 0.0079
4192 DNA topoisomerase 2-beta TOP2B 0.0073
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0071
1836 Mitogen-activated protein kinase 10 MAPK10 0.0069
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0066
2236 Casein kinase II subunit alpha CSNK2A1 0.0065
5304 UPF0166 protein TM_0021 TM_0021 0.0053
5288 Shikimate kinase aroK 0.0053
2874 Nitrogenase iron protein 1 nifH1 0.0053
5292 Putative partitioning protein TT_C1605 0.0053
5287 Signaling protein Not Available 0.0053
4346 Polynucleotide kinase pseT 0.0053
5266 Activator of hgdC 0.0053
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0053
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0053
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0053
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0053
5283 D-alanine--D-alanine ligase B ddlB 0.0053
5293 Shikimate kinase 2 aroL 0.0053
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0053
5299 D-alanine--D-alanine ligase ddl 0.0053
6598 D-alanine--D-alanine ligase ddl 0.0053
5276 Chromosomal replication initiator protein dnaA dnaA 0.0053
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0053
5259 Transcriptional regulator ntrC1 0.0053
6699 Transcriptional regulator Cgl2612 0.0053
5291 Glycogen synthase 1 glgA1 0.0053
5264 DNA replication protein REP 0.0053
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0053
5281 Plasmid segregation protein parM parM 0.0053
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0053
5285 Kinesin heavy chain KIF5B 0.0053
5315 Chaperone protein htpG htpG 0.0053
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0053
5284 Large T antigen Not Available 0.0053
5308 Preprotein translocase secA 1 subunit secA1 0.0053
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0053
5261 Phosphoribosylformylglycinamidine synthase purL 0.0053
5277 Preprotein translocase subunit secA secA 0.0053
3470 Hypothetical protein MG245 homolog MPN_348 0.0046
4106 Guanylate kinase GUK1 0.0046
4516 Guanylate kinase gmk 0.0046
2270 Dephospho-CoA kinase coaE 0.0046
3426 Glutamine synthetase glnA 0.0046
3987 Glutamine synthetase GLUL 0.0046
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0046
4837 Cag-alfa cag-alfa 0.0046
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0046
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0046
2284 Adenylate kinase adk 0.0046
2296 Adenylate kinase adk 0.0046
2311 Adenylate kinase adk 0.0046
2312 Adenylate kinase Not Available 0.0046
6277 Heat shock cognate 71 kDa protein HSPA8 0.0046
413 Amidophosphoribosyltransferase PPAT 0.0046
2515 Amidophosphoribosyltransferase purF 0.0046
3714 Amidophosphoribosyltransferase purF 0.0046
3175 Glutamate--cysteine ligase gshA 0.0046
4774 NTPase P4 Not Available 0.0046
4839 DNA polymerase III subunit tau dnaX 0.0046
5189 Trimethylamine dehydrogenase tmd 0.0046
4838 PMS1 protein homolog 2 PMS2 0.0046
2683 Mono-ADP-ribosyltransferase C3 C3 0.0043
2390 Nonsecretory ribonuclease RNASE2 0.0043
2922 Glycerol kinase glpK 0.0043
5271 Focal adhesion kinase 1 PTK2 0.0043
340 Apoptotic protease-activating factor 1 APAF1 0.0042
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.004
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.004
3669 Ribokinase rbsK 0.004
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.004
2282 Protein recA recA 0.004
2315 Protein recA recA 0.004
2332 Protein recA recA 0.004
5263 Protein recA recA 0.004
5300 Antigen peptide transporter 1 TAP1 0.0039
408 Riboflavin kinase RFK 0.0039
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0038
788 Creatine kinase M-type CKM 0.0037
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0037
2697 Uridine-cytidine kinase 2 UCK2 0.0037
2334 Dethiobiotin synthetase bioD 0.0037
6555 Dethiobiotin synthetase bioD 0.0037
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0036
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0036
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0036
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0035
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0035
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0034
6395 Myosin-14 MYH14 0.0034
2091 Endoplasmin HSP90B1 0.0034
48 Pyridoxal kinase PDXK 0.0034
702 UMP-CMP kinase CMPK1 0.0033
1422 Serine/threonine-protein kinase 6 AURKA 0.0033
3379 Kinesin-like protein KIF11 KIF11 0.0032
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0032
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0032
504 Mast/stem cell growth factor receptor KIT 0.003
509 Thymidine kinase TK 0.0029
570 Thymidine kinase TK 0.0029
2559 Thymidine kinase TK 0.0029
3430 Thymidine kinase tdk 0.0029
3518 Thymidine kinase TK 0.0029
5301 Thymidine kinase tdk 0.0029
5771 Thymidine kinase ORF36 0.0029
7009 Thymidine kinase ORF36 0.0029
5294 Nucleoside diphosphate kinase A NME1 0.0029
5682 Ribonuclease pancreatic RNASE1 0.0027
4773 Deoxycytidine kinase DCK 0.0026
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0024
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