DT-Web

DB04524 - Malonyl-Coenzyme A


Identification
Name Malonyl-Coenzyme A
Accession Number DB04524 (EXPT02180)
Type small molecule
Description A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 853.58
Groups experimental
Monoisotopic Weight 853.115602295
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


3-oxoacyl-[acyl-carrier-protein] synthase 3
Name 3-oxoacyl-[acyl-carrier-protein] synthase 3
Gene Name fabH
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8082

Predictions


Id Partner name Gene Name Score
3138 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.8082
4568 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.8082
6370 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.8082
4589 3-hydroxy-3-methylglutaryl CoA synthase mvaS 0.1041
2596 Acetyl-CoA acetyltransferase phbA 0.0898
888 3-oxoacyl-[acyl-carrier-protein] synthase 2 fabF 0.0691
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0618
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0618
1295 Fatty acid synthase FASN 0.0563
5366 Sugar-phosphate isomerase TM_1080 0.0253
2688 Peptide deformylase def 0.0253
2708 Peptide deformylase def 0.0253
3004 Peptide deformylase def 0.0253
4337 Peptide deformylase def 0.0253
4338 Peptide deformylase def 0.0253
5368 Peptide deformylase def 0.0253
5371 Peptide deformylase def 0.0253
6375 Peptide deformylase def 0.0253
6378 Peptide deformylase def 0.0253
6379 Peptide deformylase def 0.0253
6776 Peptide deformylase def 0.0253
6900 Peptide deformylase def 0.0253
5365 Metallo beta-lactamase blaVIM-2 0.0252
5369 Golgi-associated plant pathogenesis-related protein 1 GLIPR2 0.0252
4699 Methylaspartate ammonia-lyase Not Available 0.0252
5367 Peroxiredoxin prx 0.0252
3596 Deoxynucleotide monophosphate kinase 1 0.022
3858 Cathepsin L CTSL1 0.022
3105 M-phase inducer phosphatase 2 CDC25B 0.0202
2664 S-ribosylhomocysteine lyase luxS 0.0192
2725 S-ribosylhomocysteine lyase luxS 0.0192
2385 Penicillin acylase Not Available 0.0181
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0113
4564 YvbK protein yvbK 0.0093
4576 Aac(6')-Ii protein aac(6')-Ii 0.0093
2528 Fatty acid metabolism regulator protein fadR 0.0093
6740 Fatty acid metabolism regulator protein fadR 0.0093
4579 Serine acetyltransferase cysE 0.0093
6807 Serine acetyltransferase cysE 0.0093
4567 Putative acyl-CoA thioester hydrolase HI0827 HI_0827 0.0093
4577 4'-phosphopantetheinyl transferase sfp sfp 0.0093
4566 Acyl-CoA hydrolase BC_2038 0.0093
4572 Acyl-CoA hydrolase BH0798 0.0093
4037 Hypothetical protein GPX1 0.0093
4297 Hypothetical protein SP_1951 0.0093
4521 Hypothetical protein BC_2969 0.0093
4540 Hypothetical protein TM_1070 0.0093
4555 Hypothetical protein MT1739 0.0093
4569 Hypothetical protein mshD 0.0093
4578 Hypothetical protein PA3270 0.0093
4747 Hypothetical protein PA3967 0.0093
5177 Hypothetical protein TM_0096 0.0093
5194 Hypothetical protein PA1204 0.0093
5240 Hypothetical protein Rv2991 0.0093
5370 Hypothetical protein TM_1158 0.0093
5710 Hypothetical protein Tb927.5.1360 0.0093
3560 Gentamicin 3'-acetyltransferase aacC1 0.0081
4565 Aminoglycoside 6'-N-acetyltransferase aac(6')-Iy 0.0081
3489 Acetyl-coenzyme A synthetase acs 0.0081
4574 PROBABLE NAPHTHOATE SYNTHASE MENB menB 0.0081
2396 Formyl-coenzyme A transferase frc 0.0081
3457 Formyl-coenzyme A transferase frc 0.0081
4563 Acetyl transferase rimL 0.0081
3024 Crotonobetainyl-CoA:carnitine CoA-transferase caiB 0.0081
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0081
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0081
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0081
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.008
3729 Citrate synthase gltA 0.008
4575 Citrate synthase cit 0.008
4580 Citrate synthase gltA 0.008
2285 Streptogramin A acetyltransferase vatD 0.0075
3199 Phosphopantetheine adenylyltransferase coaD 0.0075
3543 Phosphopantetheine adenylyltransferase coaD 0.0075
3567 Phosphopantetheine adenylyltransferase coaD 0.0075
5289 Phosphopantetheine adenylyltransferase coaD 0.0075
2377 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Not Available 0.0074
2560 Galactoside O-acetyltransferase lacA 0.0074
3178 Formate acetyltransferase 1 pflB 0.0074
4573 Histone acetyltransferase PCAF KAT2B 0.0074
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0074
2248 Malate synthase G glcB 0.0074
3190 Malate synthase G glcB 0.0074
2371 Pantothenate kinase coaA 0.0072
4404 FcbC1 protein fcbC 0.007
2376 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD 0.0067
551 Carnitine O-acetyltransferase CRAT 0.0066
4388 Aminoglycoside 2'-N-acetyltransferase aac 0.0058
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0045
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0045
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