DT-Web

DB06693 - Mevastatin


Identification
Name Mevastatin
Accession Number DB06693
Type small molecule
Description Mevastatin or compactin is a cholesterol-lowering agent isolated from Penicillium citinium. It was the first discovered agent belonging to the class of cholesterol-lowering medications known as statins. During a search for antibiotic compounds produced by fungi in 1971, Akira Endo at Sankyo Co. (Japan) discovered a class of compounds that appeared to lower plasma cholesterol levels. Two years later, the research group isolated a compound structurally similar to hydroxymethylglutarate (HMG) that inhibited the incorporation of acetate. The compound was proposed to bind to the reductase enzyme and was named compactin. Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. Mevastatin is a pro-drug that is activated by in vivo hydrolysis of the lactone ring. It has served as one of the lead compounds for the development of the synthetic compounds used today.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 408.5283
Groups experimental
Monoisotopic Weight 408.251188884
Pharmacology
Indication Not used therapeutically due to its many side effects.
Mechanism of action Mevastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Mevastatin is a prodrug that is activated in vivo via hydrolysis of the lactone ring. The hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind with 10,000 times greater affinity than its natural substrate. The bicyclic portion of mevastatin binds to the coenzyme A portion of the active site.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Side effects include those of other statins, such as myalgias, abdominal pain, nausea. It also has a higher chance of giving more severe side effects related to myotoxicity (myopathy, myositis, rhabdomyolysis), and hepatotoxicity, than other statins. Due to these major side effects and their enhanced rate of occurance, Mevastatin is not given therapeutically.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • Avoid alcohol
  • Grape fruit juice increases blood levels of the drug

Targets


3-hydroxy-3-methylglutaryl-coenzyme A reductase
Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name HMGCR
Pharmacological action yes
Actions inhibitor
References
  • Kocarek TA, Dahn MS, Cai H, Strom SC, Mercer-Haines NA: Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5. - Pubmed
  • Cenedella RJ, Kuszak JR, Al-Ghoul KJ, Qin S, Sexton PS: Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats. J Lipid Res. 2003 Jan;44(1):198-211. - Pubmed
  • Stoebner PE, Michot C, Ligeron C, Durand L, Meynadier J, Meunier L: [Simvastatin-induced lichen planus pemphigoides] Ann Dermatol Venereol. 2003 Feb;130(2 Pt 1):187-90. - Pubmed
  • Pappu AS, Bacon SP, Illingworth DR: Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia. J Lab Clin Med. 2003 Apr;141(4):250-6. - Pubmed
  • Liu L, Zhang R, Zhao JJ, Rogers JD, Hsieh JY, Fang W, Matuszewski BK, Dobrinska MR: Determination of simvastatin-derived HMG-CoA reductase inhibitors in biomatrices using an automated enzyme inhibition assay with radioactivity detection. J Pharm Biomed Anal. 2003 Apr 24;32(1):107-23. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.3646

Enzymes


Liver carboxylesterase 1
Name Liver carboxylesterase 1
Gene Name CES1
Actions inhibitor
References
  • Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR: Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J Mol Biol. 2005 Sep 9;352(1):165-77. - Pubmed
DTHybrid score 0.5518

Predictions


Id Partner name Gene Name Score
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.3646
4589 3-hydroxy-3-methylglutaryl CoA synthase mvaS 0.0417
1588 Multidrug resistance protein 1 ABCB1 0.0375
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.0365
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0354
6606 Platelet-activating factor acetylhydrolase IB subunit gamma PAFAH1B3 0.0348
4175 Platelet-activating factor acetylhydrolase PLA2G7 0.0348
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0332
4512 Cytochrome P450 3A4 CYP3A4 0.0299
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0298
4757 Cytochrome P450 2C9 CYP2C9 0.0287
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0266
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0263
4118 Cytochrome P450 3A5 CYP3A5 0.0259
4924 Cytochrome P450 2C8 CYP2C8 0.024
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0229
6016 Cytochrome P450 2C19 CYP2C19 0.02
4119 Cytochrome P450 2D6 CYP2D6 0.02
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0199
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0195
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0194
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0187
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0184
6030 Cytochrome P450 2B6 CYP2B6 0.0177
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0176
587 Serum albumin ALB 0.0173
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0164
2164 Multidrug resistance-associated protein 4 ABCC4 0.015
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0148
6107 Cytochrome P450 3A7 CYP3A7 0.0139
2178 Metabotropic glutamate receptor 5 GRM5 0.0136
6142 Solute carrier family 22 member 8 SLC22A8 0.013
244 Angiotensin-converting enzyme ACE 0.0125
1141 Sialidase-1 NEU1 0.012
64 Neuraminidase NA 0.012
641 Neuraminidase NA 0.012
2676 Neuraminidase NA 0.012
3026 Neuraminidase NA 0.012
3519 Neuraminidase NA 0.012
6007 Neuraminidase NA 0.012
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0112
862 Multidrug resistance-associated protein 1 ABCC1 0.011
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0108
3611 Cytidine deaminase cdd 0.0106
3707 Cytidine deaminase cdd 0.0106
4211 Cytidine deaminase CDA 0.0106
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0105
5482 Sialidase-2 NEU2 0.0102
776 Bile salt export pump ABCB11 0.0101
3639 Thymidine phosphorylase deoA 0.0101
3936 Thymidine phosphorylase TYMP 0.0101
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.01
232 Corticosteroid-binding globulin SERPINA6 0.0095
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0088
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0088
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0088
6141 Sodium/bile acid cotransporter SLC10A1 0.0086
24 Thymidylate synthase TMP1 0.0086
359 Thymidylate synthase TYMS 0.0086
2626 Thymidylate synthase thyA 0.0086
2729 Thymidylate synthase thyA 0.0086
5352 Thymidylate synthase THYA 0.0086
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0084
551 Carnitine O-acetyltransferase CRAT 0.0083
871 Glucocorticoid receptor NR3C1 0.0081
2636 Shikimate dehydrogenase aroE 0.0079
3515 Shikimate dehydrogenase aroE 0.0079
1630 Integrin beta-2 ITGB2 0.0076
5414 Fiber protein L5 0.0071
5418 Fiber protein L5 0.0071
1756 E-selectin SELE 0.0071
54 Prothrombin F2 0.0071
6013 Cytochrome P450 2E1 CYP2E1 0.0068
5669 50S ribosomal protein L27 rpmA 0.0066
5675 Chaperone protein torD torD 0.0065
5670 Organic hydroperoxide resistance protein ohr 0.0065
5672 Molybdenum cofactor biosynthesis protein A moaA 0.0065
5410 Unsaturated glucuronyl hydrolase ugl 0.0065
5676 Axin-1 AXIN1 0.0065
5673 C protein alpha-antigen bca 0.0065
122 P2Y purinoceptor 12 P2RY12 0.0064
4200 Cytochrome P450 1A2 CYP1A2 0.0064
3629 Endo-N-acetylneuraminidase Not Available 0.0062
5416 Coat protein VP1 Not Available 0.0061
1130 Lithostathine 1 alpha REG1A 0.0061
6044 Serum paraoxonase/lactonase 3 PON3 0.0059
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0059
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0059
6143 Solute carrier family 22 member 7 SLC22A7 0.0058
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0057
33 Cystine/glutamate transporter SLC7A11 0.0057
2324 Botulinum neurotoxin type B botB 0.0057
6579 Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A 0.0057
3547 Enterotoxin type B entB 0.0057
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0057
2058 P-selectin SELP 0.0056
572 Integrin alpha-L ITGAL 0.0056
4811 Amylosucrase ams 0.0053
2280 Listeriolysin regulatory protein prfA 0.0052
3191 Histidinol dehydrogenase hisD 0.0052
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0052
191 Peptide methionine sulfoxide reductase MSRA 0.0052
909 Maleylacetoacetate isomerase GSTZ1 0.0052
6168 Solute carrier family 22 member 16 SLC22A16 0.0051
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0051
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0051
611 Retinal dehydrogenase 1 ALDH1A1 0.0051
4122 Histone deacetylase 2 HDAC2 0.005
2570 Tetanus toxin tetX 0.0049
1024 Solute carrier family 22 member 11 SLC22A11 0.0047
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0045
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0043
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0043
6024 Cytochrome P450 1A1 CYP1A1 0.0042
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0042
2723 Cholera enterotoxin subunit B ctxB 0.0042
1353 DNA topoisomerase 1 TOP1 0.004
3552 DNA topoisomerase 1 topA 0.004
2314 Triosephosphate isomerase TPI 0.004
3417 Triosephosphate isomerase tpiA 0.004
3443 Triosephosphate isomerase tpiA 0.004
6346 Triosephosphate isomerase TPI1 0.004
2371 Pantothenate kinase coaA 0.0039
6220 Aryl hydrocarbon receptor AHR 0.0039
3947 Xanthine dehydrogenase/oxidase XDH 0.0038
1729 Solute carrier family 22 member 6 SLC22A6 0.0037
738 Monocarboxylate transporter 1 SLC16A1 0.0037
952 Dipeptidyl peptidase 4 DPP4 0.0036
4564 YvbK protein yvbK 0.0036
4567 Putative acyl-CoA thioester hydrolase HI0827 HI_0827 0.0036
4566 Acyl-CoA hydrolase BC_2038 0.0036
4572 Acyl-CoA hydrolase BH0798 0.0036
4576 Aac(6')-Ii protein aac(6')-Ii 0.0036
4577 4'-phosphopantetheinyl transferase sfp sfp 0.0036
2528 Fatty acid metabolism regulator protein fadR 0.0036
6740 Fatty acid metabolism regulator protein fadR 0.0036
4579 Serine acetyltransferase cysE 0.0036
6807 Serine acetyltransferase cysE 0.0036
4037 Hypothetical protein GPX1 0.0036
4297 Hypothetical protein SP_1951 0.0036
4521 Hypothetical protein BC_2969 0.0036
4540 Hypothetical protein TM_1070 0.0036
4555 Hypothetical protein MT1739 0.0036
4569 Hypothetical protein mshD 0.0036
4578 Hypothetical protein PA3270 0.0036
4747 Hypothetical protein PA3967 0.0036
5177 Hypothetical protein TM_0096 0.0036
5194 Hypothetical protein PA1204 0.0036
5240 Hypothetical protein Rv2991 0.0036
5370 Hypothetical protein TM_1158 0.0036
5710 Hypothetical protein Tb927.5.1360 0.0036
1757 Myeloperoxidase MPO 0.0035
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0034
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0034
833 Organic cation/carnitine transporter 1 SLC22A4 0.0032
3489 Acetyl-coenzyme A synthetase acs 0.0031
2391 Ferrochelatase hemH 0.0031
6502 Ferrochelatase DKFZp686P18130 0.0031
1591 Ferrochelatase, mitochondrial FECH 0.0031
2396 Formyl-coenzyme A transferase frc 0.0031
3457 Formyl-coenzyme A transferase frc 0.0031
4574 PROBABLE NAPHTHOATE SYNTHASE MENB menB 0.0031
3024 Crotonobetainyl-CoA:carnitine CoA-transferase caiB 0.0031
3729 Citrate synthase gltA 0.0031
4575 Citrate synthase cit 0.0031
4580 Citrate synthase gltA 0.0031
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0031
4563 Acetyl transferase rimL 0.0031
4565 Aminoglycoside 6'-N-acetyltransferase aac(6')-Iy 0.0031
3560 Gentamicin 3'-acetyltransferase aacC1 0.0031
6042 Prostaglandin reductase 2 PTGR2 0.0031
6136 Multidrug resistance-associated protein 5 ABCC5 0.003
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0029
6500 Phospholipase A2 PLA2G1B 0.0029
3923 Cholinesterase BCHE 0.0029
1192 Sulfotransferase 1A1 SULT1A1 0.0029
646 Malate dehydrogenase, cytoplasmic MDH1 0.0029
4573 Histone acetyltransferase PCAF KAT2B 0.0029
2377 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Not Available 0.0029
2560 Galactoside O-acetyltransferase lacA 0.0029
3199 Phosphopantetheine adenylyltransferase coaD 0.0029
3543 Phosphopantetheine adenylyltransferase coaD 0.0029
3567 Phosphopantetheine adenylyltransferase coaD 0.0029
5289 Phosphopantetheine adenylyltransferase coaD 0.0029
2248 Malate synthase G glcB 0.0028
3190 Malate synthase G glcB 0.0028
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0028
2285 Streptogramin A acetyltransferase vatD 0.0028
3178 Formate acetyltransferase 1 pflB 0.0028
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0028
666 NADP-dependent malic enzyme ME1 0.0028
118 Organic cation/carnitine transporter 2 SLC22A5 0.0028
6043 Putative G-protein coupled receptor 44 GPR44 0.0027
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0027
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0027
6493 Cytochrome c oxidase subunit 6C COX6C 0.0027
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0027
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0027
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0027
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0027
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0027
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0027
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0027
6559 Cytochrome c oxidase subunit 2 ctaC 0.0027
6669 Cytochrome c oxidase subunit 2 ctaC 0.0027
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0027
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0027
6558 Cytochrome c oxidase subunit 1 ctaD 0.0027
4404 FcbC1 protein fcbC 0.0027
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0027
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0026
2376 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD 0.0026
6147 Solute carrier family 22 member 3 SLC22A3 0.0026
5322 Oxidoreductase ydhF ydhF 0.0025
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0025
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0025
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0025
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0025
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0025
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0025
5332 MtdA bifunctional protein mtdA 0.0025
3778 NAD(P) transhydrogenase subunit beta pntB 0.0025
4403 Protein iolS iolS 0.0025
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0025
5330 General stress protein 69 yhdN 0.0025
3587 Gastrotropin FABP6 0.0025
2540 Choloylglycine hydrolase cbh 0.0025
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0025
1313 Lactoylglutathione lyase GLO1 0.0025
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0024
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0024
615 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0024
3138 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0024
4568 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0024
6370 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0024
4388 Aminoglycoside 2'-N-acetyltransferase aac 0.0024
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0024
6501 Fatty acid-binding protein, liver FABP1 0.0024
2596 Acetyl-CoA acetyltransferase phbA 0.0023
2981 Phospholipase A2, membrane associated PLA2G2A 0.0023
654 Flavin reductase BLVRB 0.0023
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0023
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0022
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0022
5073 Ferredoxin--NADP reductase petH 0.0022
5076 Ferredoxin--NADP reductase fpr 0.0022
5119 Ferredoxin--NADP reductase petH 0.0022
5121 Ferredoxin--NADP reductase fpr 0.0022
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0022
5328 Prostaglandin F synthase Tb11.02.2310 0.0022
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0022
517 Alcohol dehydrogenase 1C ADH1C 0.0022
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0022
3446 NADP-dependent alcohol dehydrogenase adh 0.0022
2286 Isocitrate dehydrogenase [NADP] icd 0.0022
2302 Isocitrate dehydrogenase [NADP] icd 0.0022
2771 Isocitrate dehydrogenase [NADP] icd 0.0022
4582 Putative pteridine reductase 2 ptr2 0.0022
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0022
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0022
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0022
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0022
989 L-xylulose reductase DCXR 0.0022
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0022
76 Nitric-oxide synthase, brain NOS1 0.0021
444 Alcohol dehydrogenase 1B ADH1B 0.0021
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0021
869 Estrogen receptor beta ESR2 0.0021
6297 Prostaglandin reductase 1 PTGR1 0.002
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.002
4531 Putative ketoacyl reductase actIII 0.002
3062 Aspartate-semialdehyde dehydrogenase asd 0.002
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.002
3809 Estrogen-related receptor gamma ESRRG 0.002
2159 Quinone oxidoreductase CRYZ 0.002
4878 Glycoprotein hormones alpha chain CGA 0.002
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.002
1072 Granzyme B GZMB 0.002
4877 Beta-mannanase man 0.002
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.002
4850 Beta-2-glycoprotein 1 APOH 0.002
4856 CD209 antigen CD209 0.002
4889 Ig epsilon chain C region IGHE 0.002
4869 Major capsid protein A430L 0.002
4852 Reticulon-4 receptor RTN4R 0.002
4880 Membrane cofactor protein CD46 0.002
757 Fusion glycoprotein F0 F 0.002
4875 Fusion glycoprotein F0 F 0.002
4721 Beta-1,4-mannanase manA 0.002
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.002
1354 Beta-glucuronidase GUSB 0.002
442 Envelope glycoprotein gp41 0.002
4859 Envelope glycoprotein env 0.002
4189 Alpha-galactosidase A GLA 0.002
4845 ADAM 33 ADAM33 0.002
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.002
3352 Structural polyprotein Not Available 0.002
3628 Structural polyprotein Not Available 0.002
4892 Structural polyprotein Not Available 0.002
6137 Multidrug resistance-associated protein 6 ABCC6 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
2675 Pteridine reductase 1 PTR1 0.0019
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0019
1124 Sepiapterin reductase SPR 0.0019
20 Prostaglandin G/H synthase 1 PTGS1 0.0019
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0018
822 Aldose reductase AKR1B1 0.0018
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0017
6858 Inactive carboxylesterase 4 CES1P1 0.0017
793 T-cell surface antigen CD2 CD2 0.0017
4861 Interleukin-6 receptor alpha chain IL6R 0.0017
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0017
3837 Cytokine receptor common beta chain CSF2RB 0.0017
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0017
1898 Cytochrome P450 1B1 CYP1B1 0.0017
365 Dihydrofolate reductase DHFR 0.0017
2381 Dihydrofolate reductase DFR1 0.0017
2833 Dihydrofolate reductase Not Available 0.0017
2931 Dihydrofolate reductase folA 0.0017
3544 Dihydrofolate reductase folA 0.0017
3682 Dihydrofolate reductase folA 0.0017
6642 Dihydrofolate reductase folA 0.0017
6756 Dihydrofolate reductase dfrA 0.0017
136 Estrogen receptor ESR1 0.0017
3811 Cytochrome P450 19A1 CYP19A1 0.0017
5288 Shikimate kinase aroK 0.0017
5287 Signaling protein Not Available 0.0017
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0017
5293 Shikimate kinase 2 aroL 0.0017
5304 UPF0166 protein TM_0021 TM_0021 0.0017
4346 Polynucleotide kinase pseT 0.0017
5292 Putative partitioning protein TT_C1605 0.0017
5276 Chromosomal replication initiator protein dnaA dnaA 0.0017
5266 Activator of hgdC 0.0017
5259 Transcriptional regulator ntrC1 0.0017
6699 Transcriptional regulator Cgl2612 0.0017
2874 Nitrogenase iron protein 1 nifH1 0.0017
5283 D-alanine--D-alanine ligase B ddlB 0.0017
5281 Plasmid segregation protein parM parM 0.0017
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0017
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0017
5299 D-alanine--D-alanine ligase ddl 0.0017
6598 D-alanine--D-alanine ligase ddl 0.0017
5315 Chaperone protein htpG htpG 0.0017
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0017
5261 Phosphoribosylformylglycinamidine synthase purL 0.0017
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0017
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0017
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0017
5291 Glycogen synthase 1 glgA1 0.0017
5264 DNA replication protein REP 0.0017
5277 Preprotein translocase subunit secA secA 0.0017
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0017
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0017
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0017
5284 Large T antigen Not Available 0.0017
5308 Preprotein translocase secA 1 subunit secA1 0.0017
5285 Kinesin heavy chain KIF5B 0.0017
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0016
4890 Hemagglutinin HA 0.0016
6566 Hemagglutinin Not Available 0.0016
1379 Interleukin-12 subunit beta IL12B 0.0016
1184 Interferon beta IFNB1 0.0015
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0015
2297 Genome polyprotein Not Available 0.0015
2322 Genome polyprotein Not Available 0.0015
2694 Genome polyprotein Not Available 0.0015
2719 Genome polyprotein Not Available 0.0015
2860 Genome polyprotein Not Available 0.0015
2928 Genome polyprotein Not Available 0.0015
3160 Genome polyprotein Not Available 0.0015
3260 Genome polyprotein Not Available 0.0015
4783 Genome polyprotein Not Available 0.0015
5726 Genome polyprotein Not Available 0.0015
5779 Genome polyprotein Not Available 0.0015
5867 Genome polyprotein Not Available 0.0015
6253 Genome polyprotein Not Available 0.0015
6301 Genome polyprotein Not Available 0.0015
6380 Genome polyprotein Not Available 0.0015
6381 Genome polyprotein Not Available 0.0015
6437 Genome polyprotein Not Available 0.0015
6520 Genome polyprotein Not Available 0.0015
6521 Genome polyprotein Not Available 0.0015
6652 Genome polyprotein Not Available 0.0015
6734 Genome polyprotein Not Available 0.0015
6735 Genome polyprotein Not Available 0.0015
6736 Genome polyprotein Not Available 0.0015
6737 Genome polyprotein Not Available 0.0015
6738 Genome polyprotein Not Available 0.0015
6739 Genome polyprotein Not Available 0.0015
6744 Genome polyprotein Not Available 0.0015
6748 Genome polyprotein Not Available 0.0015
6894 Genome polyprotein Not Available 0.0015
6898 Genome polyprotein Not Available 0.0015
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0015
5718 Cytochrome P450 2A6 CYP2A6 0.0015
290 Prostaglandin G/H synthase 2 PTGS2 0.0014
1859 Prostatic acid phosphatase ACPP 0.0014
3140 Hemagglutinin-neuraminidase HN 0.0014
3609 Hemagglutinin-neuraminidase HN 0.0014
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0014
3444 Cyanovirin-N Not Available 0.0014
554 Low-density lipoprotein receptor LDLR 0.0014
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0014
852 Heparin cofactor 2 SERPIND1 0.0014
4787 Envelope glycoprotein gp160 env 0.0013
4820 Envelope glycoprotein gp160 env 0.0013
5727 Envelope glycoprotein gp160 env 0.0013
4120 NADPH--cytochrome P450 reductase POR 0.0013
4106 Guanylate kinase GUK1 0.0013
4516 Guanylate kinase gmk 0.0013
4837 Cag-alfa cag-alfa 0.0013
413 Amidophosphoribosyltransferase PPAT 0.0013
2515 Amidophosphoribosyltransferase purF 0.0013
3714 Amidophosphoribosyltransferase purF 0.0013
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0013
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0013
5646 Galactokinase GALK1 0.0013
4838 PMS1 protein homolog 2 PMS2 0.0013
4839 DNA polymerase III subunit tau dnaX 0.0013
5302 TrwB trwB 0.0013
5265 FtsH ftsH 0.0013
5189 Trimethylamine dehydrogenase tmd 0.0013
4774 NTPase P4 Not Available 0.0013
6277 Heat shock cognate 71 kDa protein HSPA8 0.0013
2270 Dephospho-CoA kinase coaE 0.0013
2284 Adenylate kinase adk 0.0013
2296 Adenylate kinase adk 0.0013
2311 Adenylate kinase adk 0.0013
2312 Adenylate kinase Not Available 0.0013
3470 Hypothetical protein MG245 homolog MPN_348 0.0013
3175 Glutamate--cysteine ligase gshA 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0013
595 Fibrinogen alpha chain FGA 0.0013
4666 Fucose-binding lectin PA-IIL lecB 0.0013
2372 Bifunctional tail protein 9 0.0013
2683 Mono-ADP-ribosyltransferase C3 C3 0.0013
340 Apoptotic protease-activating factor 1 APAF1 0.0012
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0012
5300 Antigen peptide transporter 1 TAP1 0.0012
3480 Mannan endo-1,4-beta-mannosidase manA 0.0012
2390 Nonsecretory ribonuclease RNASE2 0.0012
958 Insulin-like growth factor 1 receptor IGF1R 0.0012
5312 Kinesin-like protein KIF1A KIF1A 0.0012
2922 Glycerol kinase glpK 0.0012
5271 Focal adhesion kinase 1 PTK2 0.0012
1243 Cathepsin D CTSD 0.0011
2282 Protein recA recA 0.0011
2315 Protein recA recA 0.0011
2332 Protein recA recA 0.0011
5263 Protein recA recA 0.0011
1439 Lactotransferrin LTF 0.0011
408 Riboflavin kinase RFK 0.0011
2615 Chemotaxis protein cheA cheA 0.0011
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0011
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0011
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0011
1881 Hexokinase-1 HK1 0.0011
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0011
2892 Acetylglutamate kinase argB 0.0011
3550 Acetylglutamate kinase argB 0.0011
3669 Ribokinase rbsK 0.0011
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0011
3814 Complement C1r subcomponent C1R 0.0011
825 Arsenical pump-driving ATPase ASNA1 0.0011
3435 Arsenical pump-driving ATPase arsA 0.0011
2430 Chondroitinase B cslB 0.0011
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.001
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.001
788 Creatine kinase M-type CKM 0.001
6307 Ig gamma-2 chain C region IGHG2 0.001
2727 S-adenosylmethionine synthetase metK 0.001
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.001
2581 Chondroitinase AC cslA 0.001
309 Antithrombin-III SERPINC1 0.001
6847 Lactase-phlorizin hydrolase LCT 0.001
2334 Dethiobiotin synthetase bioD 0.001
6555 Dethiobiotin synthetase bioD 0.001
2697 Uridine-cytidine kinase 2 UCK2 0.001
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.001
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.001
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2207 Rhodopsin RHO 0.0009
48 Pyridoxal kinase PDXK 0.0009
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0009
702 UMP-CMP kinase CMPK1 0.0009
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0009
2091 Endoplasmin HSP90B1 0.0009
207 Glutathione synthetase GSS 0.0009
5269 Glutathione synthetase gshB 0.0009
6395 Myosin-14 MYH14 0.0009
2251 Thymidylate kinase tmk 0.0009
2254 Thymidylate kinase DTYMK 0.0009
3522 Thymidylate kinase tmk 0.0009
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0009
816 Biliverdin reductase A BLVRA 0.0009
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0009
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0009
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0009
1422 Serine/threonine-protein kinase 6 AURKA 0.0009
4785 Ig gamma-1 chain C region IGHG1 0.0009
3379 Kinesin-like protein KIF11 KIF11 0.0008
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0008
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0008
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0008
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0008
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0008
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0008
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0008
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0008
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0008
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0008
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0008
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0008
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0008
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0008
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0008
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0008
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0008
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0008
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0008
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0008
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0008
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0008
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0008
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0008
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0008
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0008
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0008
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0008
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0008
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0008
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0008
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0008
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0008
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0008
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0008
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0008
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0008
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0008
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0008
107 C-4 methylsterol oxidase SC4MOL 0.0008
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0008
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0008
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0008
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0008
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0008
729 GDP-L-fucose synthetase TSTA3 0.0008
3463 GDP-L-fucose synthetase fcl 0.0008
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0008
167 L-lactate dehydrogenase C chain LDHC 0.0008
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0008
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0008
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0008
3726 D-3-phosphoglycerate dehydrogenase serA 0.0008
4291 D-3-phosphoglycerate dehydrogenase serA 0.0008
206 3-keto-steroid reductase HSD17B7 0.0008
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0008
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0008
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0008
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0008
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0008
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0008
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0008
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0008
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0008
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0008
34 7-dehydrocholesterol reductase DHCR7 0.0008
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0008
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0008
711 UDP-glucose 6-dehydrogenase UGDH 0.0008
3672 UDP-glucose 6-dehydrogenase hasB 0.0008
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0008
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0008
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0008
643 Peroxisomal bifunctional enzyme EHHADH 0.0008
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0008
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0008
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0008
3822 Actin, alpha skeletal muscle ACTA1 0.0008
504 Mast/stem cell growth factor receptor KIT 0.0008
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0008
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0008
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0008
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0008
396 Alcohol dehydrogenase 4 ADH4 0.0008
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0008
328 Sorbitol dehydrogenase SORD 0.0008
597 Dihydropteridine reductase QDPR 0.0008
857 Malate dehydrogenase, mitochondrial MDH2 0.0008
509 Thymidine kinase TK 0.0008
570 Thymidine kinase TK 0.0008
2559 Thymidine kinase TK 0.0008
3430 Thymidine kinase tdk 0.0008
3518 Thymidine kinase TK 0.0008
5301 Thymidine kinase tdk 0.0008
5771 Thymidine kinase ORF36 0.0008
7009 Thymidine kinase ORF36 0.0008
5294 Nucleoside diphosphate kinase A NME1 0.0008
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0008
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0008
12 Alcohol dehydrogenase class 3 ADH5 0.0008
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0008
77 L-lactate dehydrogenase B chain LDHB 0.0008
1721 Glycogen synthase kinase-3 beta GSK3B 0.0008
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0007
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0007
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0007
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0007
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0007
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
6026 Alcohol dehydrogenase 6 ADH6 0.0007
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0007
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0007
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0007
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0007
626 Cysteine dioxygenase type 1 CDO1 0.0007
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0007
4773 Deoxycytidine kinase DCK 0.0007
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0007
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0007
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0007
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0007
5682 Ribonuclease pancreatic RNASE1 0.0007
13 Aminomethyltransferase, mitochondrial AMT 0.0007
627 11-cis retinol dehydrogenase RDH5 0.0007
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0007
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0007
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0007
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0007
569 Retinal dehydrogenase 2 ALDH1A2 0.0007
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0006
251 Alcohol dehydrogenase 1A ADH1A 0.0006
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0006
279 Tyrosinase TYR 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0006
380 Cytochrome P450 17A1 CYP17A1 0.0006
714 Glutathione reductase, mitochondrial GSR 0.0006
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0005
468 Cytochrome P450 4A11 CYP4A11 0.0005
6020 Aldehyde oxidase AOX1 0.0005
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