DT-Web

DB03169 - (S)-Hmg-Coa


Identification
Name (S)-Hmg-Coa
Accession Number DB03169 (EXPT01758)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups experimental
Monoisotopic Weight Not Available
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


3-hydroxy-3-methylglutaryl-coenzyme A reductase
Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name mvaA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5414
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name HMGCR
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5414
3-hydroxy-3-methylglutaryl CoA synthase
Name 3-hydroxy-3-methylglutaryl CoA synthase
Gene Name mvaS
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.7072

Predictions


Id Partner name Gene Name Score
2596 Acetyl-CoA acetyltransferase phbA 0.2321
615 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.1678
3138 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.1678
4568 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.1678
6370 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.1678
4601 HMG-CoA synthase mvaS 0.1031
4574 PROBABLE NAPHTHOATE SYNTHASE MENB menB 0.1011
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.088
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0762
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0757
4604 Liver carboxylesterase 1 CES1 0.0351
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0269
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0195
4757 Cytochrome P450 2C9 CYP2C9 0.0191
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0189
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0188
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0188
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0188
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0187
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0184
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0181
4118 Cytochrome P450 3A5 CYP3A5 0.0179
4924 Cytochrome P450 2C8 CYP2C8 0.0179
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0151
4576 Aac(6')-Ii protein aac(6')-Ii 0.015
4564 YvbK protein yvbK 0.015
4567 Putative acyl-CoA thioester hydrolase HI0827 HI_0827 0.015
2528 Fatty acid metabolism regulator protein fadR 0.015
6740 Fatty acid metabolism regulator protein fadR 0.015
4577 4'-phosphopantetheinyl transferase sfp sfp 0.015
4566 Acyl-CoA hydrolase BC_2038 0.015
4572 Acyl-CoA hydrolase BH0798 0.015
4579 Serine acetyltransferase cysE 0.015
6807 Serine acetyltransferase cysE 0.015
4037 Hypothetical protein GPX1 0.015
4297 Hypothetical protein SP_1951 0.015
4521 Hypothetical protein BC_2969 0.015
4540 Hypothetical protein TM_1070 0.015
4555 Hypothetical protein MT1739 0.015
4569 Hypothetical protein mshD 0.015
4578 Hypothetical protein PA3270 0.015
4747 Hypothetical protein PA3967 0.015
5177 Hypothetical protein TM_0096 0.015
5194 Hypothetical protein PA1204 0.015
5240 Hypothetical protein Rv2991 0.015
5370 Hypothetical protein TM_1158 0.015
5710 Hypothetical protein Tb927.5.1360 0.015
6016 Cytochrome P450 2C19 CYP2C19 0.0148
4512 Cytochrome P450 3A4 CYP3A4 0.0144
1588 Multidrug resistance protein 1 ABCB1 0.0142
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0137
4119 Cytochrome P450 2D6 CYP2D6 0.0134
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0132
3489 Acetyl-coenzyme A synthetase acs 0.0131
3024 Crotonobetainyl-CoA:carnitine CoA-transferase caiB 0.0131
2396 Formyl-coenzyme A transferase frc 0.0131
3457 Formyl-coenzyme A transferase frc 0.0131
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0131
4563 Acetyl transferase rimL 0.0131
3560 Gentamicin 3'-acetyltransferase aacC1 0.0131
4565 Aminoglycoside 6'-N-acetyltransferase aac(6')-Iy 0.0131
2371 Pantothenate kinase coaA 0.0126
3199 Phosphopantetheine adenylyltransferase coaD 0.0121
3543 Phosphopantetheine adenylyltransferase coaD 0.0121
3567 Phosphopantetheine adenylyltransferase coaD 0.0121
5289 Phosphopantetheine adenylyltransferase coaD 0.0121
2560 Galactoside O-acetyltransferase lacA 0.0121
2377 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Not Available 0.0121
4573 Histone acetyltransferase PCAF KAT2B 0.0121
2285 Streptogramin A acetyltransferase vatD 0.012
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.012
2248 Malate synthase G glcB 0.012
3190 Malate synthase G glcB 0.012
3178 Formate acetyltransferase 1 pflB 0.012
4404 FcbC1 protein fcbC 0.0114
551 Carnitine O-acetyltransferase CRAT 0.0113
6030 Cytochrome P450 2B6 CYP2B6 0.0111
2376 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD 0.0109
6107 Cytochrome P450 3A7 CYP3A7 0.0107
4388 Aminoglycoside 2'-N-acetyltransferase aac 0.0099
2636 Shikimate dehydrogenase aroE 0.0079
3515 Shikimate dehydrogenase aroE 0.0079
3191 Histidinol dehydrogenase hisD 0.0077
1630 Integrin beta-2 ITGB2 0.0076
776 Bile salt export pump ABCB11 0.0072
611 Retinal dehydrogenase 1 ALDH1A1 0.0072
5669 50S ribosomal protein L27 rpmA 0.0066
5675 Chaperone protein torD torD 0.0065
5670 Organic hydroperoxide resistance protein ohr 0.0065
5672 Molybdenum cofactor biosynthesis protein A moaA 0.0065
5410 Unsaturated glucuronyl hydrolase ugl 0.0065
5676 Axin-1 AXIN1 0.0065
5673 C protein alpha-antigen bca 0.0065
587 Serum albumin ALB 0.0065
2164 Multidrug resistance-associated protein 4 ABCC4 0.0064
862 Multidrug resistance-associated protein 1 ABCC1 0.0061
6044 Serum paraoxonase/lactonase 3 PON3 0.0059
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0057
33 Cystine/glutamate transporter SLC7A11 0.0057
6579 Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A 0.0057
572 Integrin alpha-L ITGAL 0.0056
646 Malate dehydrogenase, cytoplasmic MDH1 0.0053
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0053
4811 Amylosucrase ams 0.0053
2280 Listeriolysin regulatory protein prfA 0.0052
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0052
191 Peptide methionine sulfoxide reductase MSRA 0.0052
6141 Sodium/bile acid cotransporter SLC10A1 0.0052
909 Maleylacetoacetate isomerase GSTZ1 0.0052
4122 Histone deacetylase 2 HDAC2 0.005
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0047
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0045
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0042
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0041
444 Alcohol dehydrogenase 1B ADH1B 0.0041
2314 Triosephosphate isomerase TPI 0.004
3417 Triosephosphate isomerase tpiA 0.004
3443 Triosephosphate isomerase tpiA 0.004
6346 Triosephosphate isomerase TPI1 0.004
2683 Mono-ADP-ribosyltransferase C3 C3 0.0039
6220 Aryl hydrocarbon receptor AHR 0.0039
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0037
738 Monocarboxylate transporter 1 SLC16A1 0.0037
24 Thymidylate synthase TMP1 0.0036
359 Thymidylate synthase TYMS 0.0036
2626 Thymidylate synthase thyA 0.0036
2729 Thymidylate synthase thyA 0.0036
5352 Thymidylate synthase THYA 0.0036
816 Biliverdin reductase A BLVRA 0.0035
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0035
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0035
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0035
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0033
4428 Redox-sensing transcriptional repressor rex rex 0.0033
4507 Alanine dehydrogenase ald 0.0033
4455 Glycerol dehydrogenase gldA 0.0033
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0033
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0033
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0033
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0033
4502 Formate dehydrogenase Not Available 0.0033
4423 Levodione reductase lvr 0.0033
4487 Transcriptional regulator nadR nadR 0.0033
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0033
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0033
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0033
4500 L-lactate dehydrogenase 2 ldh2 0.0033
4447 Hypothetical protein yhfP yhfP 0.0033
3381 Alcohol dehydrogenase Not Available 0.0033
4508 Alcohol dehydrogenase adhA 0.0033
4414 Dehydrogenase TT_P0035 0.0033
2350 3-isopropylmalate dehydrogenase leuB 0.0033
3092 3-isopropylmalate dehydrogenase leuB 0.0033
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0033
4418 AGR_L_3209p AGR_L_3209 0.0033
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0033
4497 Benzyl alcohol dehydrogenase xylB 0.0033
4449 ADP-ribosyltransferase Not Available 0.0033
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0033
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0033
3729 Citrate synthase gltA 0.0033
4575 Citrate synthase cit 0.0033
4580 Citrate synthase gltA 0.0033
4435 L-aspartate dehydrogenase nadX 0.0033
4451 Vip2Ac vip2Ac 0.0033
4472 Glucose 1-dehydrogenase Not Available 0.0033
4467 Alpha-glucosidase, putative TM_0752 0.0033
4443 Quinate/shikimate dehydrogenase ydiB 0.0033
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0033
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0033
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0033
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0033
396 Alcohol dehydrogenase 4 ADH4 0.0033
328 Sorbitol dehydrogenase SORD 0.0033
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0033
597 Dihydropteridine reductase QDPR 0.0033
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0032
12 Alcohol dehydrogenase class 3 ADH5 0.0031
77 L-lactate dehydrogenase B chain LDHB 0.0031
1024 Solute carrier family 22 member 11 SLC22A11 0.0031
6143 Solute carrier family 22 member 7 SLC22A7 0.0031
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0031
6136 Multidrug resistance-associated protein 5 ABCC5 0.003
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.003
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.003
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.003
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.003
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.003
473 L-lactate dehydrogenase A chain LDHA 0.003
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0029
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0029
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0029
4486 Phenol 2-hydroxylase component B pheA2 0.0029
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0029
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0029
2336 2,3-diketo-L-gulonate reductase dlgD 0.0029
4498 Ornithine cyclodeaminase PP3533 0.0029
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0029
4503 NADPH-flavin oxidoreductase frp 0.0029
3615 Dihydrodipicolinate reductase dapB 0.0029
3618 Dihydrodipicolinate reductase dapB 0.0029
4462 Dihydrodipicolinate reductase dapB 0.0029
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0029
4509 Acetoin(diacetyl) reductase budC 0.0029
2393 Maltose-6'-phosphate glucosidase glvA 0.0029
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0029
2424 L-lactate dehydrogenase ldh 0.0029
2641 L-lactate dehydrogenase Not Available 0.0029
4437 L-lactate dehydrogenase ldh 0.0029
4442 L-lactate dehydrogenase ldh 0.0029
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0029
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0029
126 D-lactate dehydrogenase dld 0.0029
3545 D-lactate dehydrogenase Not Available 0.0029
4510 D-lactate dehydrogenase ldhA 0.0029
4427 TDP-glucose-4,6-dehydratase desIV 0.0029
2967 CDP-paratose 2-epimerase rfbE 0.0029
3081 3-dehydroquinate synthase aroB 0.0029
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0029
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0029
2018 Deoxyhypusine synthase DHPS 0.0029
4482 UDP-galactose 4-epimerase galE 0.0029
4439 Ferredoxin reductase bphA4 0.0029
2538 6-phospho-beta-glucosidase bglT bglT 0.0029
4496 C-terminal-binding protein 1 CTBP1 0.0029
4450 Iota toxin component Ia Not Available 0.0029
4477 Dihydrolipoyl dehydrogenase lpdV 0.0029
5077 Dihydrolipoyl dehydrogenase Not Available 0.0029
5117 Dihydrolipoyl dehydrogenase lpd 0.0029
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0029
2591 Urocanate hydratase hutU 0.0029
2507 Diphtheria toxin Not Available 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0029
6024 Cytochrome P450 1A1 CYP1A1 0.0029
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0028
666 NADP-dependent malic enzyme ME1 0.0028
569 Retinal dehydrogenase 2 ALDH1A2 0.0028
6142 Solute carrier family 22 member 8 SLC22A8 0.0027
251 Alcohol dehydrogenase 1A ADH1A 0.0027
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0027
3367 GDP-mannose 6-dehydrogenase algD 0.0027
4343 Alpha-glucosidase aglA 0.0027
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0027
4504 WbpP Not Available 0.0027
4440 NADH peroxidase npr 0.0027
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0027
4318 Siroheme synthase cysG 0.0027
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0027
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0026
4476 Mannitol dehydrogenase mtlD 0.0026
5322 Oxidoreductase ydhF ydhF 0.0025
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0025
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0025
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0025
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0025
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0025
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0025
5332 MtdA bifunctional protein mtdA 0.0025
3778 NAD(P) transhydrogenase subunit beta pntB 0.0025
4403 Protein iolS iolS 0.0025
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0025
5330 General stress protein 69 yhdN 0.0025
63 Malate dehydrogenase mdh 0.0025
2329 Malate dehydrogenase mdh 0.0025
3445 Malate dehydrogenase mdh 0.0025
4420 Malate dehydrogenase mdh 0.0025
4438 Malate dehydrogenase mdh 0.0025
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0025
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0025
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0025
3070 Adenosylhomocysteinase AHCY 0.0025
4424 Adenosylhomocysteinase PFE1050w 0.0025
6278 Adenosylhomocysteinase ahcY 0.0025
2826 Glucose--fructose oxidoreductase gfo 0.0025
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0025
2617 Nitric oxide synthase oxygenase nos 0.0025
2701 Nitric oxide synthase oxygenase nos 0.0025
1729 Solute carrier family 22 member 6 SLC22A6 0.0025
327 Glutathione reductase gor 0.0024
5110 Glutathione reductase GR2 0.0024
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0024
714 Glutathione reductase, mitochondrial GSR 0.0024
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0024
4200 Cytochrome P450 1A2 CYP1A2 0.0024
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0024
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0024
4491 DNA ligase, NAD-dependent ligA 0.0023
517 Alcohol dehydrogenase 1C ADH1C 0.0023
654 Flavin reductase BLVRB 0.0023
2762 UDP-glucose 4-epimerase GALE 0.0022
3461 UDP-glucose 4-epimerase galE 0.0022
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0022
5073 Ferredoxin--NADP reductase petH 0.0022
5076 Ferredoxin--NADP reductase fpr 0.0022
5119 Ferredoxin--NADP reductase petH 0.0022
5121 Ferredoxin--NADP reductase fpr 0.0022
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0022
5328 Prostaglandin F synthase Tb11.02.2310 0.0022
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0022
3446 NADP-dependent alcohol dehydrogenase adh 0.0022
2286 Isocitrate dehydrogenase [NADP] icd 0.0022
2302 Isocitrate dehydrogenase [NADP] icd 0.0022
2771 Isocitrate dehydrogenase [NADP] icd 0.0022
4582 Putative pteridine reductase 2 ptr2 0.0022
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0022
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0022
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0022
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0022
989 L-xylulose reductase DCXR 0.0022
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0021
6297 Prostaglandin reductase 1 PTGR1 0.002
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.002
4531 Putative ketoacyl reductase actIII 0.002
3062 Aspartate-semialdehyde dehydrogenase asd 0.002
2159 Quinone oxidoreductase CRYZ 0.002
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
2675 Pteridine reductase 1 PTR1 0.0019
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0019
1124 Sepiapterin reductase SPR 0.0019
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0019
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
822 Aldose reductase AKR1B1 0.0018
365 Dihydrofolate reductase DHFR 0.0017
2381 Dihydrofolate reductase DFR1 0.0017
2833 Dihydrofolate reductase Not Available 0.0017
2931 Dihydrofolate reductase folA 0.0017
3544 Dihydrofolate reductase folA 0.0017
3682 Dihydrofolate reductase folA 0.0017
6642 Dihydrofolate reductase folA 0.0017
6756 Dihydrofolate reductase dfrA 0.0017
5288 Shikimate kinase aroK 0.0017
5287 Signaling protein Not Available 0.0017
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0017
5293 Shikimate kinase 2 aroL 0.0017
5304 UPF0166 protein TM_0021 TM_0021 0.0017
4346 Polynucleotide kinase pseT 0.0017
5292 Putative partitioning protein TT_C1605 0.0017
5276 Chromosomal replication initiator protein dnaA dnaA 0.0017
5266 Activator of hgdC 0.0017
5259 Transcriptional regulator ntrC1 0.0017
6699 Transcriptional regulator Cgl2612 0.0017
2874 Nitrogenase iron protein 1 nifH1 0.0017
5283 D-alanine--D-alanine ligase B ddlB 0.0017
5281 Plasmid segregation protein parM parM 0.0017
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0017
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0017
5299 D-alanine--D-alanine ligase ddl 0.0017
6598 D-alanine--D-alanine ligase ddl 0.0017
5315 Chaperone protein htpG htpG 0.0017
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0017
5261 Phosphoribosylformylglycinamidine synthase purL 0.0017
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0017
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0017
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0017
5291 Glycogen synthase 1 glgA1 0.0017
5264 DNA replication protein REP 0.0017
5277 Preprotein translocase subunit secA secA 0.0017
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0017
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0017
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0017
5284 Large T antigen Not Available 0.0017
5308 Preprotein translocase secA 1 subunit secA1 0.0017
5285 Kinesin heavy chain KIF5B 0.0017
4120 NADPH--cytochrome P450 reductase POR 0.0013
4106 Guanylate kinase GUK1 0.0013
4516 Guanylate kinase gmk 0.0013
4837 Cag-alfa cag-alfa 0.0013
413 Amidophosphoribosyltransferase PPAT 0.0013
2515 Amidophosphoribosyltransferase purF 0.0013
3714 Amidophosphoribosyltransferase purF 0.0013
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0013
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0013
5646 Galactokinase GALK1 0.0013
4838 PMS1 protein homolog 2 PMS2 0.0013
4839 DNA polymerase III subunit tau dnaX 0.0013
5302 TrwB trwB 0.0013
5265 FtsH ftsH 0.0013
5189 Trimethylamine dehydrogenase tmd 0.0013
4774 NTPase P4 Not Available 0.0013
6277 Heat shock cognate 71 kDa protein HSPA8 0.0013
2270 Dephospho-CoA kinase coaE 0.0013
2284 Adenylate kinase adk 0.0013
2296 Adenylate kinase adk 0.0013
2311 Adenylate kinase adk 0.0013
2312 Adenylate kinase Not Available 0.0013
3470 Hypothetical protein MG245 homolog MPN_348 0.0013
3175 Glutamate--cysteine ligase gshA 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0013
76 Nitric-oxide synthase, brain NOS1 0.0013
340 Apoptotic protease-activating factor 1 APAF1 0.0012
5300 Antigen peptide transporter 1 TAP1 0.0012
2390 Nonsecretory ribonuclease RNASE2 0.0012
5312 Kinesin-like protein KIF1A KIF1A 0.0012
2922 Glycerol kinase glpK 0.0012
5271 Focal adhesion kinase 1 PTK2 0.0012
2282 Protein recA recA 0.0011
2315 Protein recA recA 0.0011
2332 Protein recA recA 0.0011
5263 Protein recA recA 0.0011
408 Riboflavin kinase RFK 0.0011
2615 Chemotaxis protein cheA cheA 0.0011
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0011
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0011
1881 Hexokinase-1 HK1 0.0011
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0011
2892 Acetylglutamate kinase argB 0.0011
3550 Acetylglutamate kinase argB 0.0011
3669 Ribokinase rbsK 0.0011
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0011
825 Arsenical pump-driving ATPase ASNA1 0.0011
3435 Arsenical pump-driving ATPase arsA 0.0011
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.001
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.001
788 Creatine kinase M-type CKM 0.001
2727 S-adenosylmethionine synthetase metK 0.001
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.001
2334 Dethiobiotin synthetase bioD 0.001
6555 Dethiobiotin synthetase bioD 0.001
2697 Uridine-cytidine kinase 2 UCK2 0.001
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.001
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.001
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
48 Pyridoxal kinase PDXK 0.0009
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0009
702 UMP-CMP kinase CMPK1 0.0009
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0009
2091 Endoplasmin HSP90B1 0.0009
207 Glutathione synthetase GSS 0.0009
5269 Glutathione synthetase gshB 0.0009
6395 Myosin-14 MYH14 0.0009
2251 Thymidylate kinase tmk 0.0009
2254 Thymidylate kinase DTYMK 0.0009
3522 Thymidylate kinase tmk 0.0009
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0009
1422 Serine/threonine-protein kinase 6 AURKA 0.0009
3379 Kinesin-like protein KIF11 KIF11 0.0008
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0008
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0008
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0008
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0008
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0008
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0008
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0008
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0008
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0008
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0008
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0008
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0008
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0008
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0008
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0008
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0008
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0008
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0008
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0008
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0008
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0008
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0008
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0008
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0008
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0008
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0008
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0008
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0008
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0008
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0008
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0008
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0008
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0008
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0008
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0008
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0008
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0008
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0008
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0008
107 C-4 methylsterol oxidase SC4MOL 0.0008
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0008
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0008
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0008
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0008
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0008
729 GDP-L-fucose synthetase TSTA3 0.0008
3463 GDP-L-fucose synthetase fcl 0.0008
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0008
167 L-lactate dehydrogenase C chain LDHC 0.0008
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0008
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0008
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0008
3726 D-3-phosphoglycerate dehydrogenase serA 0.0008
4291 D-3-phosphoglycerate dehydrogenase serA 0.0008
206 3-keto-steroid reductase HSD17B7 0.0008
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0008
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0008
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0008
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0008
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0008
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0008
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0008
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0008
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0008
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0008
34 7-dehydrocholesterol reductase DHCR7 0.0008
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0008
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0008
711 UDP-glucose 6-dehydrogenase UGDH 0.0008
3672 UDP-glucose 6-dehydrogenase hasB 0.0008
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0008
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0008
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0008
643 Peroxisomal bifunctional enzyme EHHADH 0.0008
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0008
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0008
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0008
3822 Actin, alpha skeletal muscle ACTA1 0.0008
504 Mast/stem cell growth factor receptor KIT 0.0008
857 Malate dehydrogenase, mitochondrial MDH2 0.0008
509 Thymidine kinase TK 0.0008
570 Thymidine kinase TK 0.0008
2559 Thymidine kinase TK 0.0008
3430 Thymidine kinase tdk 0.0008
3518 Thymidine kinase TK 0.0008
5301 Thymidine kinase tdk 0.0008
5771 Thymidine kinase ORF36 0.0008
7009 Thymidine kinase ORF36 0.0008
5294 Nucleoside diphosphate kinase A NME1 0.0008
1721 Glycogen synthase kinase-3 beta GSK3B 0.0008
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0007
6026 Alcohol dehydrogenase 6 ADH6 0.0007
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0007
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0007
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0007
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0007
626 Cysteine dioxygenase type 1 CDO1 0.0007
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0007
4773 Deoxycytidine kinase DCK 0.0007
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0007
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0007
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0007
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0007
5682 Ribonuclease pancreatic RNASE1 0.0007
13 Aminomethyltransferase, mitochondrial AMT 0.0007
627 11-cis retinol dehydrogenase RDH5 0.0007
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0007
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0007
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0007
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0006
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0006
279 Tyrosinase TYR 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0006
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0006
380 Cytochrome P450 17A1 CYP17A1 0.0006
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0005
468 Cytochrome P450 4A11 CYP4A11 0.0005
6020 Aldehyde oxidase AOX1 0.0005
3947 Xanthine dehydrogenase/oxidase XDH 0.0004
↑