DT-Web: DB00731

Identification

Name

Nateglinide

Accession Number

DB00731 (APRD00593)

Type

small molecule

Description

Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to ? cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those na?ve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Nateglinide is extensively metabolized in the liver and excreted in urine (83%) and feces (10%). The major metabolites possess less activity than the parent compound. One minor metabolite, the isoprene, has the same potency as its parent compound.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

317.4226

Groups

approved

Monoisotopic Weight

317.199093735

Pharmacology

Indication

For the treatment of non-insulin dependent-diabetes mellitus in conjunction with diet and exercise.

Mechanism of action

Nateglinide activity is dependent on the presence functioning ? cells and glucose. In contrast to sulfonylurea insulin secretatogogues, nateglinide has no effect on insulin release in the absence of glucose. Rather, it potentiates the effect of extracellular glucose on ATP-sensitive potassium channel and has little effect on insulin levels between meals and overnight. As such, nateglinide is more effective at reducing postprandial blood glucose levels than fasting blood glucose levels and requires a longer duration of therapy (approximately one month) before decreases in fasting blood glucose are observed. The insulinotropic effects of nateglinide are highest at intermediate glucose levels (3 to 10 mmol/L) and it does not increase insulin release already stimulated by high glucose concentrations (greater than 15 mmol/L). Nateglinide appears to be selective for pancreatic ? cells and does not appear to affect skeletal or cardiac muscle or thyroid tissue.

Absorption

Rapidly absorbed following oral administration prior to a meal, absolute bioavailability is estimated to be approximately 73%. Peak plasma concentrations generally occur within 1 hour of oral administration. Onset of action is <20 minutes and the duration of action is approximately 4 hours.

Protein binding

98% bound to serum proteins, primarily serum albumin and to a lesser extent α1 acid glycoprotein

Biotransformation

Hepatic, via cytochrome P450 isoenzymes CYP2C9 (70%) and CYP3A4 (30%). Metabolism is via hydroxylation followed by glucuronidation. The major metabolites have less antidiabetic activity than nateglinide, but the isoprene minor metabolite has antidiabetic activity comparable to that of nateglinide.

Route of elimination

Urine (83%) and feces (10%)

Toxicity

An overdose may result in an exaggerated glucose-lowering effect with the development of hypoglycemic symptoms.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Glucosamine	Possible hyperglycemia
Somatropin recombinant	Somatropin may antagonize the hypoglycemic effect of nateglinide. Monitor for changes in fasting and postprandial blood sugars.
Telithromycin	Telithromycin may reduce clearance of Nateglenide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Nateglenide if Telithromycin is initiated, discontinued or dose changed.
Tolbutamide	Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Nateglinide. Consider alternate therapy or monitor for changes in Nateglinide therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of nateglinide by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nateglinide if voriconazole is initiated, discontinued or dose changed.

Food Interactions

Take upto 30 minutes before meals.

ATP-binding cassette transporter sub-family C member 8
Name	ATP-binding cassette transporter sub-family C member 8
Gene Name	ABCC8
Pharmacological action	yes
Actions	inhibitor
References	Hu S, Wang S, Fanelli B, Bell PA, Dunning BE, Geisse S, Schmitz R, Boettcher BR: Pancreatic beta-cell K(ATP) channel activity and membrane-binding studies with nateglinide: A comparison with sulfonylureas and repaglinide. J Pharmacol Exp Ther. 2000 May;293(2):444-52. - Pubmed Sunaga Y, Gonoi T, Shibasaki T, Ichikawa K, Kusama H, Yano H, Seino S: The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide. Eur J Pharmacol. 2001 Nov 9;431(1):119-25. - Pubmed Hansen AM, Christensen IT, Hansen JB, Carr RD, Ashcroft FM, Wahl P: Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1. Diabetes. 2002 Sep;51(9):2789-95. - Pubmed Chachin M, Yamada M, Fujita A, Matsuoka T, Matsushita K, Kurachi Y: Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic beta-cell-type K(ATP) channels. J Pharmacol Exp Ther. 2003 Mar;304(3):1025-32. - Pubmed Norman P, Rabasseda X: Nateglinide: A structurally novel, short-acting, hypoglycemic agent. Drugs Today (Barc). 2001 Jun;37(6):411-426. - Pubmed Dornhorst A: Insulinotropic meglitinide analogues. Lancet. 2001 Nov 17;358(9294):1709-16. - Pubmed
DTHybrid score	0.3953
Peroxisome proliferator-activated receptor gamma
Name	Peroxisome proliferator-activated receptor gamma
Gene Name	PPARG
Pharmacological action	unknown
Actions	agonist
References	Scarsi M, Podvinec M, Roth A, Hug H, Kersten S, Albrecht H, Schwede T, Meyer UA, Rucker C: Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach. Mol Pharmacol. 2007 Feb;71(2):398-406. Epub 2006 Nov 2. - Pubmed
DTHybrid score	1.027

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6241
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8076
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.4352
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.3439
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.5947
UDP-glucuronosyltransferase 1-9
Name	UDP-glucuronosyltransferase 1-9
Gene Name	UGT1A9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.304
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5331

Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	substrate
References	Uchida Y, Kamiie J, Ohtsuki S, Terasaki T: Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter. Pharm Res. 2007 Dec;24(12):2281-96. Epub 2007 Oct 16. - Pubmed
DTHybrid score	0.217
Monocarboxylate transporter 1
Name	Monocarboxylate transporter 1
Gene Name	SLC16A1
Actions	substrate
References	Okamura A, Emoto A, Koyabu N, Ohtani H, Sawada Y: Transport and uptake of nateglinide in Caco-2 cells and its inhibitory effect on human monocarboxylate transporter MCT1. Br J Pharmacol. 2002 Oct;137(3):391-9. - Pubmed
DTHybrid score	0.2616
Oligopeptide transporter, small intestine isoform
Name	Oligopeptide transporter, small intestine isoform
Gene Name	SLC15A1
Actions	inhibitor
References	Terada T, Sawada K, Saito H, Hashimoto Y, Inui K: Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2. Eur J Pharmacol. 2000 Mar 24;392(1-2):11-7. - Pubmed
DTHybrid score	0.5685
Oligopeptide transporter, kidney isoform
Name	Oligopeptide transporter, kidney isoform
Gene Name	SLC15A2
Actions	inhibitor
References	Terada T, Sawada K, Saito H, Hashimoto Y, Inui K: Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2. Eur J Pharmacol. 2000 Mar 24;392(1-2):11-7. - Pubmed
DTHybrid score	0.5478
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Uwai Y, Saito H, Hashimoto Y, Inui K: Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1. Eur J Pharmacol. 2000 Jun 16;398(2):193-7. - Pubmed
DTHybrid score	0.4668

Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions
References	Not Available
DTHybrid score	0.217
Monocarboxylate transporter 1
Name	Monocarboxylate transporter 1
Gene Name	SLC16A1
Actions
References	Not Available
DTHybrid score	0.2616
Oligopeptide transporter, small intestine isoform
Name	Oligopeptide transporter, small intestine isoform
Gene Name	SLC15A1
Actions
References	Not Available
DTHybrid score	0.5685
Oligopeptide transporter, kidney isoform
Name	Oligopeptide transporter, kidney isoform
Gene Name	SLC15A2
Actions
References	Not Available
DTHybrid score	0.5478
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions
References	Not Available
DTHybrid score	0.4668

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.392
1588	Multidrug resistance protein 1	ABCB1	0.3814
4924	Cytochrome P450 2C8	CYP2C8	0.3396
4200	Cytochrome P450 1A2	CYP1A2	0.2892
290	Prostaglandin G/H synthase 2	PTGS2	0.2808
6142	Solute carrier family 22 member 8	SLC22A8	0.1842
244	Angiotensin-converting enzyme	ACE	0.1812
6030	Cytochrome P450 2B6	CYP2B6	0.1705
118	Organic cation/carnitine transporter 2	SLC22A5	0.1471
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1407
6013	Cytochrome P450 2E1	CYP2E1	0.1401
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1395
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1359
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.131
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1264
489	Monocarboxylate transporter 2	SLC16A7	0.1233
6024	Cytochrome P450 1A1	CYP1A1	0.122
1024	Solute carrier family 22 member 11	SLC22A11	0.1208
633	Penicillin-binding proteins 1A/1B	pbpA	0.1199
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.1174
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.1171
862	Multidrug resistance-associated protein 1	ABCC1	0.1094
6143	Solute carrier family 22 member 7	SLC22A7	0.109
5718	Cytochrome P450 2A6	CYP2A6	0.1044
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0986
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0972
500	Monocarboxylate transporter 4	SLC16A3	0.0864
6106	Cytochrome P450 2C18	CYP2C18	0.0833
492	Histamine H1 receptor	HRH1	0.0762
6145	Solute carrier family 22 member 1	SLC22A1	0.0761
824	Sodium-dependent serotonin transporter	SLC6A4	0.0694
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0677
556	Alpha-1A adrenergic receptor	ADRA1A	0.0672
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0634
847	Mu-type opioid receptor	OPRM1	0.0626
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0625
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0625
645	Penicillin-binding protein 1A	mrcA	0.0619
5805	Penicillin-binding protein 1A	ponA	0.0619
6185	Penicillin-binding protein 1A	mrcA	0.0619
6799	Penicillin-binding protein 1A	pbpA	0.0619
1757	Myeloperoxidase	MPO	0.0613
776	Bile salt export pump	ABCB11	0.061
275	Arachidonate 5-lipoxygenase	ALOX5	0.0608
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0608
6144	Solute carrier family 22 member 2	SLC22A2	0.0585
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0584
1	Peptidoglycan synthetase ftsI	ftsI	0.058
4155	Peptidoglycan synthetase ftsI	ftsI	0.058
831	D(2) dopamine receptor	DRD2	0.0566
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0566
4604	Liver carboxylesterase 1	CES1	0.0539
6136	Multidrug resistance-associated protein 5	ABCC5	0.0521
543	Penicillin-binding protein 1B	mrcB	0.0486
6186	Penicillin-binding protein 1B	ponB	0.0486
6822	Penicillin-binding protein 1b	pbp1b	0.0486
6844	Penicillin-binding protein 1b	pbp1b	0.0486
6228	Nuclear receptor coactivator 1	NCOA1	0.0465
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0465
696	Kappa-type opioid receptor	OPRK1	0.0464
467	Delta-type opioid receptor	OPRD1	0.0462
632	Alpha-1B adrenergic receptor	ADRA1B	0.0452
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0448
3923	Cholinesterase	BCHE	0.0441
318	Alpha-2A adrenergic receptor	ADRA2A	0.0432
459	Retinoic acid receptor RXR-alpha	RXRA	0.0426
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0424
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0423
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0419
891	Dihydropteroate synthase	folP	0.0415
5359	Dihydropteroate synthase	folP	0.0415
7175	Dihydropteroate synthase	sulI	0.0415
766	Beta-2 adrenergic receptor	ADRB2	0.0412
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0404
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0401
183	Vascular endothelial growth factor A	VEGFA	0.0391
3810	Catechol O-methyltransferase	COMT	0.0388
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0384
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0384
1898	Cytochrome P450 1B1	CYP1B1	0.0384
3811	Cytochrome P450 19A1	CYP19A1	0.0379
23	D(1A) dopamine receptor	DRD1	0.0378
6031	Cytochrome P450 3A43	CYP3A43	0.0373
338	DNA polymerase	UL30	0.0364
379	DNA polymerase	UL54	0.0364
697	DNA polymerase	ORF28	0.0364
2482	DNA polymerase	43	0.0364
4104	DNA polymerase	BALF5	0.0364
713	Sodium-dependent dopamine transporter	SLC6A3	0.0362
6141	Sodium/bile acid cotransporter	SLC10A1	0.0353
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0351
1385	Angiotensin-converting enzyme 2	ACE2	0.035
193	Beta-1 adrenergic receptor	ADRB1	0.035
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0344
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.034
6148	Multidrug resistance-associated protein 7	ABCC10	0.0339
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0339
6147	Solute carrier family 22 member 3	SLC22A3	0.0332
833	Organic cation/carnitine transporter 1	SLC22A4	0.0329
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0327
723	Cytosolic phospholipase A2	PLA2G4A	0.032
590	5-hydroxytryptamine 2C receptor	HTR2C	0.032
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0318
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0317
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0315
3917	Methylenetetrahydrofolate reductase	MTHFR	0.031
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0305
871	Glucocorticoid receptor	NR3C1	0.0302
789	Alpha-1D adrenergic receptor	ADRA1D	0.03
731	HIV-1 protease	HIV-1 protease	0.0299
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0294
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0294
638	D(3) dopamine receptor	DRD3	0.0293
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0291
6102	Arylamine N-acetyltransferase 2	NAT2	0.0289
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0284
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0282
6241	Nuclear receptor coactivator 2	NCOA2	0.028
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0277
6067	Penicillin binding protein 2a	mecA	0.0271
70	Type-1 angiotensin II receptor	AGTR1	0.0262
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0261
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.026
844	Epidermal growth factor receptor	EGFR	0.0257
136	Estrogen receptor	ESR1	0.0254
465	Calmodulin	CALM1	0.0252
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0249
2929	(S)-2-haloacid dehalogenase	dhlB	0.0248
2995	(S)-2-haloacid dehalogenase	Not Available	0.0248
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0246
234	Plasminogen	PLG	0.0246
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.024
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0238
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0237
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0236
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0236
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0236
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0236
115	Penicillin-binding protein 2	mrdA	0.0235
6069	Penicillin-binding protein 2	mrdA	0.0235
6118	Penicillin-binding protein 2	penA	0.0235
6187	Penicillin-binding protein 2	pbpA	0.0235
6686	Penicillin-binding protein 2	pbp2	0.0235
6939	Penicillin-binding protein 2	mrdA	0.0235
7163	Penicillin-binding protein 2	pbpA	0.0235
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0235
504	Mast/stem cell growth factor receptor	KIT	0.0232
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0231
56	Delta-aminolevulinic acid dehydratase	ALAD	0.023
2356	Delta-aminolevulinic acid dehydratase	hemB	0.023
3613	Delta-aminolevulinic acid dehydratase	hemB	0.023
3674	Delta-aminolevulinic acid dehydratase	hemB	0.023
6085	Fatty acid-binding protein, intestinal	FABP2	0.0227
6137	Multidrug resistance-associated protein 6	ABCC6	0.0227
3941	Amine oxidase [flavin-containing] A	MAOA	0.0227
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0226
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0225
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0225
817	DNA topoisomerase 2-alpha	TOP2A	0.0221
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0218
260	Cytochrome P450 51	ERG11	0.0217
761	Cytochrome P450 51	ERG11	0.0217
3163	Cytochrome P450 51	cyp51	0.0217
295	Carbonic anhydrase 1	CA1	0.0217
24	Thymidylate synthase	TMP1	0.0215
359	Thymidylate synthase	TYMS	0.0215
2626	Thymidylate synthase	thyA	0.0215
2729	Thymidylate synthase	thyA	0.0215
5352	Thymidylate synthase	THYA	0.0215
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0215
592	Carbonic anhydrase 4	CA4	0.0214
404	DNA gyrase subunit A	gyrA	0.0212
6224	DNA gyrase subunit A	gyrA	0.0212
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0211
885	5-hydroxytryptamine 1B receptor	HTR1B	0.021
373	Transthyretin	TTR	0.0209
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0209
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0207
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0206
6149	Solute carrier family 22 member 10	SLC22A10	0.0205
811	Translocator protein	TSPO	0.0203
614	Progesterone receptor	PGR	0.0201
5626	Nucleoside diphosphate kinase B	NME2	0.0199
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0198
2544	Bacterial leucyl aminopeptidase	Not Available	0.0198
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0194
6182	Cytochrome P450 2J2	CYP2J2	0.0192
432	D(4) dopamine receptor	DRD4	0.0191
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0191
3866	Serum amyloid A protein	SAA1	0.019
1200	AMBP protein	AMBP	0.019
1932	Apolipoprotein E	APOE	0.019
6012	Tryptophan 2,3-dioxygenase	TDO2	0.019
629	Alpha-2B adrenergic receptor	ADRA2B	0.019
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0188
26	Vascular endothelial growth factor receptor 3	FLT4	0.0187
378	Alpha-2C adrenergic receptor	ADRA2C	0.0187
6500	Phospholipase A2	PLA2G1B	0.0186
380	Cytochrome P450 17A1	CYP17A1	0.0184
1050	Bile salt sulfotransferase	SULT2A1	0.0182
1650	Heme carrier protein 1	SLC46A1	0.0182
357	Carbonic anhydrase 2	CA2	0.018
146	Androgen receptor	AR	0.0179
6043	Putative G-protein coupled receptor 44	GPR44	0.0179
32	Vascular endothelial growth factor receptor 1	FLT1	0.0178
703	NADPH azoreductase	azr	0.0178
407	Vascular endothelial growth factor receptor 2	KDR	0.0178
33	Cystine/glutamate transporter	SLC7A11	0.0177
159	Penicillin-binding protein 2B	penA	0.0175
6121	Penicillin-binding protein 2B	penA	0.0175
756	Sex hormone-binding globulin	SHBG	0.0175
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0172
4252	Penicillin-binding protein 5	dacA	0.0171
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0171
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
3939	Amine oxidase [flavin-containing] B	MAOB	0.0168
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0166
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0166
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0164
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0163
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.016
3184	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0159
3315	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0159
5294	Nucleoside diphosphate kinase A	NME1	0.0159
3179	2-isopropylmalate synthase	leuA	0.0159
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0159
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0159
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0159
122	P2Y purinoceptor 12	P2RY12	0.0157
232	Corticosteroid-binding globulin	SERPINA6	0.0156
737	Mineralocorticoid receptor	NR3C2	0.0155
3639	Thymidine phosphorylase	deoA	0.0153
3936	Thymidine phosphorylase	TYMP	0.0153
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0152
6020	Aldehyde oxidase	AOX1	0.0151
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0151
468	Cytochrome P450 4A11	CYP4A11	0.015
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.015
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0149
3060	Leukotriene A-4 hydrolase	LTA4H	0.0149
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0149
1141	Sialidase-1	NEU1	0.0148
64	Neuraminidase	NA	0.0148
641	Neuraminidase	NA	0.0148
2676	Neuraminidase	NA	0.0148
3026	Neuraminidase	NA	0.0148
3519	Neuraminidase	NA	0.0148
6007	Neuraminidase	NA	0.0148
705	Glutamate receptor 1	GRIA1	0.0148
558	Solute carrier family 12 member 1	SLC12A1	0.0148
3312	Fatty acid-binding protein, brain	FABP7	0.0148
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0147
768	FK506-binding protein 1A	FKBP1A	0.0146
6103	Arylamine N-acetyltransferase 1	NAT1	0.0146
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0144
3426	Glutamine synthetase	glnA	0.0143
3987	Glutamine synthetase	GLUL	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
5650	NimA-related protein	DR_0842	0.0142
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0142
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0142
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.014
165	FL cytokine receptor	FLT3	0.0139
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0139
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0139
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0139
477	DNA topoisomerase 4 subunit A	parC	0.0138
886	DNA topoisomerase 4 subunit A	parC	0.0138
6226	DNA topoisomerase 4 subunit A	parC	0.0138
6151	Monocarboxylate transporter 10	SLC16A10	0.0138
3760	Penicillin-binding protein 5 precursor	dacA	0.0136
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0136
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0135
1656	CYP2B protein	CYP2B	0.0135
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0135
1517	Beta-3 adrenergic receptor	ADRB3	0.0135
163	D(1B) dopamine receptor	DRD5	0.0134
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0134
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0134
716	5-hydroxytryptamine 7 receptor	HTR7	0.0133
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0133
1648	Elastin	ELN	0.0131
273	Apoptosis regulator Bcl-2	BCL2	0.0131
1507	Cytochrome c	CYCS	0.013
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0128
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0128
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0128
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0128
6126	Carbonic anhydrase 7	CA7	0.0127
3334	Deacetoxycephalosporin C synthetase	cefE	0.0127
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0126
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0126
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
509	Thymidine kinase	TK	0.0126
570	Thymidine kinase	TK	0.0126
2559	Thymidine kinase	TK	0.0126
3430	Thymidine kinase	tdk	0.0126
3518	Thymidine kinase	TK	0.0126
5301	Thymidine kinase	tdk	0.0126
5771	Thymidine kinase	ORF36	0.0126
7009	Thymidine kinase	ORF36	0.0126
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0126
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0125
2021	Thrombomodulin	THBD	0.0125
1618	High affinity nerve growth factor receptor	NTRK1	0.0124
6033	High affinity interleukin-8 receptor A	CXCR1	0.0123
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0123
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0123
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0123
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0123
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0121
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0121
6220	Aryl hydrocarbon receptor	AHR	0.012
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.012
293	Gamma-glutamyl hydrolase	GGH	0.0119
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0118
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0118
54	Prothrombin	F2	0.0118
860	Nicotinamide N-methyltransferase	NNMT	0.0118
928	Nicotinic acid receptor 2	GPR109B	0.0118
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0118
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0118
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0118
699	Nicotinic acid receptor 1	GPR109A	0.0118
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0117
5787	Angiopoietin-1 receptor	TEK	0.0117
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0116
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
427	Substance-P receptor	TACR1	0.0114
5482	Sialidase-2	NEU2	0.0114
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0114
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0113
3932	Glutathione S-transferase A2	GSTA2	0.0112
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0112
94	5-hydroxytryptamine 4 receptor	HTR4	0.0112
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0112
4790	Glycosyltransferase GtfA	gtfA	0.011
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0109
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0108
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0108
6167	Organic solute transporter subunit beta	OSTB	0.0107
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0107
6166	Organic solute transporter subunit alpha	OSTA	0.0107
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0107
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0107
2853	14 kDa fatty acid-binding protein	Not Available	0.0105
707	72 kDa type IV collagenase	MMP2	0.0105
1405	Thiopurine S-methyltransferase	TPMT	0.0105
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0104
482	Glycine receptor subunit alpha-1	GLRA1	0.0104
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0104
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0103
6014	Cytochrome P450 2A13	CYP2A13	0.0103
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0103
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0102
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0102
867	Penicillin-binding protein 3	pbpC	0.0102
6119	Penicillin-binding protein 3	pbp3	0.0102
7154	Penicillin-binding protein 3	pbp3	0.0102
7157	Penicillin-binding protein 3	LMHCC_2184	0.0102
7162	Penicillin-binding protein 3	pbpB	0.0102
7172	Penicillin-binding protein 3	pbp3	0.0102
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0102
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0102
2320	Thymidine kinase, cytosolic	TK1	0.0102
952	Dipeptidyl peptidase 4	DPP4	0.0101
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0101
124	Histamine H2 receptor	HRH2	0.01
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.01
65	Matrix metalloproteinase-9	Not Available	0.01
140	30S ribosomal protein S9	rpsI	0.01
6719	30S ribosomal protein S9	rpsI	0.01
6725	30S ribosomal protein S9	rpsI	0.01
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0099
365	Dihydrofolate reductase	DHFR	0.0099
2381	Dihydrofolate reductase	DFR1	0.0099
2833	Dihydrofolate reductase	Not Available	0.0099
2931	Dihydrofolate reductase	folA	0.0099
3544	Dihydrofolate reductase	folA	0.0099
3682	Dihydrofolate reductase	folA	0.0099
6642	Dihydrofolate reductase	folA	0.0099
6756	Dihydrofolate reductase	dfrA	0.0099
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0099
4773	Deoxycytidine kinase	DCK	0.0098
2211	Fatty acid-binding protein, heart	FABP3	0.0098
29	Tubulin beta-1 chain	TUBB1	0.0098
474	Acetylcholinesterase	ACHE	0.0098
130	Prostacyclin synthase	PTGIS	0.0097
777	Tumor necrosis factor	TNF	0.0097
1039	Histone deacetylase 9	HDAC9	0.0097
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0096
3947	Xanthine dehydrogenase/oxidase	XDH	0.0096
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0096
6042	Prostaglandin reductase 2	PTGR2	0.0096
818	50S ribosomal protein L10	rplJ	0.0095
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0095
566	Serotransferrin	TF	0.0094
1275	Estrogen sulfotransferase	SULT1E1	0.0094
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0093
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0092
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.009
1192	Sulfotransferase 1A1	SULT1A1	0.0089
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0089
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0088
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0088
1792	Tissue-type plasminogen activator	PLAT	0.0088
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0088
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0088
3685	Catabolite gene activator	crp	0.0088
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0088
4655	Adenylate cyclase	cyaC	0.0088
4759	Adenylate cyclase	cyaB2	0.0088
161	Tubulin beta chain	TUBB	0.0088
312	Tubulin beta chain	TUB2	0.0088
1010	Cytochrome P450 51A1	CYP51A1	0.0087
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0087
823	Fibroblast growth factor receptor 2	FGFR2	0.0086
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0086
1198	Serum paraoxonase/arylesterase 1	PON1	0.0086
6223	Penicillin-binding protein 1C	pbpC	0.0085
3809	Estrogen-related receptor gamma	ESRRG	0.0085
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0084
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0084
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0083
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0083
1313	Lactoylglutathione lyase	GLO1	0.0083
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0083
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0083
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0082
6113	MecA PBP2' (penicillin binding protein 2')	mecA	0.0082
2016	Dipeptidase 1	DPEP1	0.0082
185	Vasopressin V1a receptor	AVPR1A	0.0082
267	Plasminogen activator inhibitor 1	SERPINE1	0.0081
6218	Pannexin-1	PANX1	0.0081
22	30S ribosomal protein S4	rpsD	0.0081
6714	30S ribosomal protein S4	rpsD	0.0081
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.008
322	Vasopressin V2 receptor	AVPR2	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0079
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0079
4120	NADPH--cytochrome P450 reductase	POR	0.0079
869	Estrogen receptor beta	ESR2	0.0079
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0078
759	Free fatty acid receptor 1	FFAR1	0.0078
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0078
6221	Steroid hormone receptor ERR1	ESRRA	0.0077
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0076
131	Synaptic vesicular amine transporter	SLC18A2	0.0076
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0075
4760	Mll3241 protein	mll3241	0.0075
3587	Gastrotropin	FABP6	0.0074
1864	RET proto-oncogene	RET	0.0074
1196	Complement decay-accelerating factor	CD55	0.0074
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0073
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0073
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0072
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0072
1353	DNA topoisomerase 1	TOP1	0.0072
3552	DNA topoisomerase 1	topA	0.0072
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0071
718	Folate receptor gamma	FOLR3	0.0071
299	Folate receptor beta	FOLR2	0.0071
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0071
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0071
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0069
49	Endothelin B receptor	EDNRB	0.0069
68	Cannabinoid receptor 1	CNR1	0.0069
4217	Telomerase reverse transcriptase	TERT	0.0069
2112	Toll-like receptor 9	TLR9	0.0069
6432	Transporter	snf	0.0069
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0068
4237	50S ribosomal protein L22	rplV	0.0068
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0068
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0068
1053	BC269730_2	FADS1	0.0068
1395	Sodium/calcium exchanger 1	SLC8A1	0.0068
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0068
814	Ryanodine receptor 1	RYR1	0.0067
4203	Histamine N-methyltransferase	HNMT	0.0066
36	Insulin receptor	INSR	0.0066
527	Prostacyclin receptor	PTGIR	0.0066
5818	Folate receptor alpha	FOLR1	0.0066
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0066
578	Endothelin-1 receptor	EDNRA	0.0065
1629	Transcription factor AP-1	JUN	0.0065
780	Retinoic acid receptor RXR-gamma	RXRG	0.0065
3014	Ribonuclease UK114	HRSP12	0.0064
5428	Replication protein	repA	0.0064
3617	Non-heme chloroperoxidase	cpo	0.0064
5426	Non-heme chloroperoxidase	cpo	0.0064
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0064
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0064
3018	HTH-type transcriptional regulator malT	malT	0.0064
2808	Chloramphenicol acetyltransferase 3	cat3	0.0064
7	Nitric oxide synthase, inducible	NOS2	0.0063
1714	Mitogen-activated protein kinase 3	MAPK3	0.0063
6131	Carbonic anhydrase 14	CA14	0.0063
133	Dihydropterate synthase	sulI	0.0063
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0061
199	Monocarboxylate transporter 8	SLC16A2	0.0061
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0061
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0061
3601	Dihydropteroate synthase 1	folP1	0.006
3807	Dihydropteroate synthase 1	folP1	0.006
3808	Dihydropteroate synthase 2	folP2	0.006
1867	Major prion protein	PRNP	0.006
1525	Heparin-binding growth factor 2	FGF2	0.006
2539	Tubulin alpha-1 chain	TUBA4A	0.0059
88	Retinoic acid receptor RXR-beta	RXRB	0.0059
1852	Microtubule-associated protein 2	MAP2	0.0059
397	Monocarboxylate transporter 3	SLC16A8	0.0059
2417	Chloramphenicol acetyltransferase	cat	0.0058
3278	Chloramphenicol acetyltransferase	cat	0.0058
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0058
195	Monocarboxylate transporter 7	SLC16A6	0.0058
218	Monocarboxylate transporter 5	SLC16A4	0.0058
429	Monocarboxylate transporter 6	SLC16A5	0.0058
2810	Dr hemagglutinin structural subunit	draA	0.0058
6837	Serine/threonine-protein kinase 17B	STK17B	0.0057
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0057
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0057
1178	Adenosine A2a receptor	ADORA2A	0.0057
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0057
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0057
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0056
3957	Adenosine deaminase	ADA	0.0056
153	Dopamine beta-hydroxylase	DBH	0.0055
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0055
2958	Probable tautomerase ydcE	pptA	0.0055
634	Squalene monooxygenase	SQLE	0.0055
7196	Squalene monooxygenase	ERG1	0.0055
2573	Cocaine esterase	cocE	0.0055
7263	Cocaine esterase	Not Available	0.0055
6506	Stathmin-4	STMN4	0.0055
469	Annexin A1	ANXA1	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0054
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0054
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0054
3115	Ras-related protein Rab-9	RAB9A	0.0054
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0054
4238	50S ribosomal protein L4	rplD	0.0054
5578	50S ribosomal protein L4	rplD	0.0054
6173	50S ribosomal protein L4	rplD	0.0054
6219	50S ribosomal protein L4	rplD	0.0054
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0054
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0054
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0053
850	Vasopressin V1b receptor	AVPR1B	0.0053
5923	Microtubule-associated protein tau	MAPT	0.0053
5924	Microtubule-associated protein 4	MAP4	0.0053
6207	30S ribosomal protein S14	rpsN	0.0052
6209	30S ribosomal protein S19	rpsS	0.0052
6712	30S ribosomal protein S19	rpsS	0.0052
6726	30S ribosomal protein S19	rpsS	0.0052
52	Pyruvate kinase isozymes R/L	PKLR	0.0052
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0051
438	Taste receptor type 1 member 2	TAS1R2	0.0051
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0051
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
174	Sigma 1-type opioid receptor	SIGMAR1	0.0051
4226	Uridine phosphorylase 2	UPP2	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
2599	Tyrosine-protein kinase HCK	HCK	0.005
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.005
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.005
904	Glutathione S-transferase P	GSTP1	0.005
84	Nuclear receptor 0B1	NR0B1	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
16	Adenosine A1 receptor	ADORA1	0.0049
771	Pyruvate carboxylase, mitochondrial	PC	0.0049
340	Apoptotic protease-activating factor 1	APAF1	0.0049
173	Toll-like receptor 7	TLR7	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
3937	Fatty-acid amide hydrolase	FAAH	0.0048
4122	Histone deacetylase 2	HDAC2	0.0048
1483	Membrane copper amine oxidase	AOC3	0.0048
819	Penicillin-binding protein 4	dacB	0.0048
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0048
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0048
921	Glutamate receptor 2	GRIA2	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
98	Pyruvate kinase isozymes M1/M2	PKM2	0.0047
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0047
484	Tyrosine-protein kinase ABL2	ABL2	0.0047
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0046
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
4225	Uridine phosphorylase 1	UPP1	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0046
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0046
3086	Plasmepsin-2	Not Available	0.0046
856	Vitamin D3 receptor	VDR	0.0046
239	Coagulation factor X	F10	0.0046
3686	Acyl-CoA thioesterase I precursor	tesA	0.0045
5934	Cytochrome P450 26A1	CYP26A1	0.0045
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0045
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0045
284	DNA-directed RNA polymerase beta chain	rpoB	0.0044
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0044
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
6171	Solute carrier family 28 member 3	SLC28A3	0.0044
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0044
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
413	Amidophosphoribosyltransferase	PPAT	0.0044
2515	Amidophosphoribosyltransferase	purF	0.0044
3714	Amidophosphoribosyltransferase	purF	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
319	Opioid receptor, sigma 1	OPRS1	0.0044
825	Arsenical pump-driving ATPase	ASNA1	0.0043
3435	Arsenical pump-driving ATPase	arsA	0.0043
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0043
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0043
733	Activin receptor type 1B	ACVR1B	0.0043
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0043
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0043
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0043
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0043
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0043
154	AFG3-like protein 2	AFG3L2	0.0043
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0043
395	ALK tyrosine kinase receptor	Not Available	0.0043
936	Ephrin type-A receptor 2	EPHA2	0.0043
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0042
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0042
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0042
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0042
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0042
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0042
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0042
5798	Mitogen-activated protein kinase 11	MAPK11	0.0042
1630	Integrin beta-2	ITGB2	0.0042
2693	Heat-labile enterotoxin B chain	eltB	0.0042
822	Aldose reductase	AKR1B1	0.0041
887	DNA gyrase subunit B	gyrB	0.0041
4150	DNA gyrase subunit B	gyrB	0.0041
6225	DNA gyrase subunit B	gyrB	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
976	Platelet glycoprotein IX	GP9	0.0041
6122	Carbonic anhydrase 3	CA3	0.0041
106	Cannabinoid receptor 2	CNR2	0.0041
408	Riboflavin kinase	RFK	0.0041
6645	D-amino-acid oxidase	DAO	0.0041
2207	Rhodopsin	RHO	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
751	Potassium channel subfamily K member 6	KCNK6	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.004
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
1541	Metalloproteinase	mmp20	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
702	UMP-CMP kinase	CMPK1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
571	Melatonin receptor type 1A	MTNR1A	0.0038
362	Melatonin receptor type 1B	MTNR1B	0.0038
1992	Vitamin D-binding protein	GC	0.0038
292	Activin receptor type-1	ACVR1	0.0038
849	Activated CDC42 kinase 1	TNK2	0.0038
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0038
297	Adenylate cyclase type 1	ADCY1	0.0038
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0038
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0038
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0038
5353	Glutamate decarboxylase alpha	gadA	0.0037
172	Potassium channel subfamily K member 1	KCNK1	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0037
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0036
594	Thyroxine-binding globulin	SERPINA7	0.0036
3904	Alanine aminotransferase 2	GPT2	0.0036
735	Alanine aminotransferase 1	GPT	0.0036
595	Fibrinogen alpha chain	FGA	0.0036
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0036
6048	Troponin C, skeletal muscle	TNNC2	0.0035
5300	Antigen peptide transporter 1	TAP1	0.0035
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0035
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0035
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0035
1025	Aquaporin-1	AQP1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
3007	Carbonic anhydrase 12	CA12	0.0034
4205	Carbonic anhydrase 9	CA9	0.0034
162	Retinoic acid receptor gamma-1	RARG	0.0034
6146	High affinity copper uptake protein 1	SLC31A1	0.0034
6044	Serum paraoxonase/lactonase 3	PON3	0.0034
6501	Fatty acid-binding protein, liver	FABP1	0.0033
4103	Proteasome subunit beta type 2	PSMB2	0.0033
4102	Proteasome subunit beta type 5	PSMB5	0.0033
4101	Proteasome subunit beta type 1	PSMB1	0.0033
758	Thyroid hormone receptor alpha	THRA	0.0033
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0033
4311	tRNA	TRDMT1	0.0033
4325	tRNA	trmD	0.0033
4328	tRNA	trmD	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
6174	50S ribosomal protein L32	rpmF	0.0033
332	Beta-lactamase	blaZ	0.0033
2478	Beta-lactamase	ampC	0.0033
2613	Beta-lactamase	ampC	0.0033
2635	Beta-lactamase	ampC	0.0033
2700	Beta-lactamase	penP	0.0033
5445	Beta-lactamase	blaB	0.0033
6019	Beta-lactamase	SHV-7	0.0033
6701	Beta-lactamase	cphA	0.0033
1374	Natriuretic peptides B	NPPB	0.0033
1827	Gap junction alpha-1 protein	GJA1	0.0032
1908	Vascular cell adhesion protein 1	VCAM1	0.0032
740	Argininosuccinate synthase	ASS1	0.0032
865	Argininosuccinate synthase	ASS1	0.0032
2680	Argininosuccinate synthase	argG	0.0032
3194	Argininosuccinate synthase	argG	0.0032
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
518	Peroxidase/catalase T	katG	0.0032
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0032
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0032
6677	Myelin P2 protein	PMP2	0.0032
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0032
1770	Phospholipase C	PLCL1	0.0032
2841	Phospholipase C	plc	0.0032
908	Glutathione S-transferase theta-1	GSTT1	0.0032
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
4192	DNA topoisomerase 2-beta	TOP2B	0.0031
3913	Glutamic acid decarboxylase	GAD65	0.0031
572	Integrin alpha-L	ITGAL	0.0031
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0031
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
6021	Adenosine kinase	ADK	0.003
346	Thyroid hormone receptor beta-1	THRB	0.003
2236	Casein kinase II subunit alpha	CSNK2A1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
581	Cytochrome P450 2R1	CYP2R1	0.003
719	Retinoic acid receptor responder protein 1	RARRES1	0.003
770	Retinoic acid-induced protein 3	GPRC5A	0.003
654	Flavin reductase	BLVRB	0.0029
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0029
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
661	ADP/ATP translocase 1	SLC25A4	0.0029
164	Histamine H4 receptor	HRH4	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0028
3856	Fibroblast growth factor receptor 3	FGFR3	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0028
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
2449	Tubulin alpha-3 chain	TUBA1A	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
4210	Toll-like receptor 4	TLR4	0.0026
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0026
569	Retinal dehydrogenase 2	ALDH1A2	0.0026
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0025
6138	Multidrug resistance protein 3	ABCB4	0.0025
563	Thyroid peroxidase	TPO	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0025
611	Retinal dehydrogenase 1	ALDH1A1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0023
2249	Aspartate aminotransferase	aspC	0.0023
2671	Aspartate aminotransferase	aspC	0.0023
5490	Aspartate aminotransferase	Not Available	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
1291	cAMP response element-binding protein	CREB1	0.0023
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0023
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
3404	Exotoxin A	eta	0.0022
6824	Tyrosine-protein kinase Lyn	LYN	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
4041	Microsomal glutathione S-transferase 2	MGST2	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0021
1268	Neuropeptide S receptor	NPSR1	0.002
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.002
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.002
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.002
672	Prostaglandin F2-alpha receptor	PTGFR	0.002
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.002
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.002
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.002
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
1654	Interleukin-1 beta	IL1B	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0019
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0019
896	Glutathione S-transferase Mu 1	GSTM1	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0019
6072	Potassium channel subfamily K member 3	KCNK3	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0018
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
683	Potassium transporter	GK0582	0.0018
2391	Ferrochelatase	hemH	0.0018
6502	Ferrochelatase	DKFZp686P18130	0.0018
1591	Ferrochelatase, mitochondrial	FECH	0.0018
53	Solute carrier family 12 member 5	SLC12A5	0.0018
663	Solute carrier family 12 member 4	SLC12A4	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
517	Alcohol dehydrogenase 1C	ADH1C	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
310	Solute carrier family 12 member 2	SLC12A2	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0016
4031	Glutathione S-transferase A1	GSTA1	0.0016
3616	Fatty acid-binding protein, epidermal	FABP5	0.0016
5431	Lipid binding protein	Not Available	0.0016
5433	UPF0230 protein TM_1468	TM_1468	0.0016
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0015
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0015
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0015
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0015
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0015
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0015
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0015
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0015
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0015
6559	Cytochrome c oxidase subunit 2	ctaC	0.0015
6669	Cytochrome c oxidase subunit 2	ctaC	0.0015
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0015
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0015
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0015
6558	Cytochrome c oxidase subunit 1	ctaD	0.0015
494	Caspase-1	CASP1	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
268	Adenosine A2b receptor	ADORA2B	0.0014
605	Fumarate reductase flavoprotein subunit	frdA	0.0014
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0014
3673	Fumarate reductase flavoprotein subunit	fccA	0.0014
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0014
6549	Fumarate reductase flavoprotein subunit	frdA	0.0014
2540	Choloylglycine hydrolase	cbh	0.0014
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0014
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0013
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0013
1912	Excitatory amino acid transporter 1	SLC1A3	0.0013
4019	Excitatory amino acid transporter 4	SLC1A6	0.0013
922	Glutamate receptor 4	GRIA4	0.0013
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0013
4026	Aspartyl aminopeptidase	DNPEP	0.0013
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0013
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0013
4016	Excitatory amino acid transporter 5	SLC1A7	0.0013
1047	Excitatory amino acid transporter 2	SLC1A2	0.0013
927	Metabotropic glutamate receptor 8	GRM8	0.0013
664	Glutamate decarboxylase 2	GAD2	0.0013
3890	Glutamate decarboxylase 2	GAD2	0.0013
4020	Glutamyl aminopeptidase	ENPEP	0.0013
4018	Glutamate receptor delta-2 subunit	GRID2	0.0013
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0013
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0013
925	Metabotropic glutamate receptor 4	GRM4	0.0013
926	Metabotropic glutamate receptor 7	GRM7	0.0013
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0013
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0013
4027	Glutamate receptor delta-1 subunit	GRID1	0.0013
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0013
4017	5-oxoprolinase	OPLAH	0.0013
283	SEC14-like protein 2	SEC14L2	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
2077	Caspase-3	CASP3	0.0013
4948	Cytochrome c-553	Not Available	0.0013
4923	Cytochrome c3	DvMF_2499	0.0013
4945	Cytochrome c3	Not Available	0.0013
4949	Cytochrome c3	DVU_3171	0.0013
4968	Cytochrome c3	cytc3	0.0013
4997	Cytochrome c3	SO_2727	0.0013
5219	Cytochrome c3	cyd	0.0013
4902	Nine-heme cytochrome c	Ddes_2038	0.0013
3189	High-molecular-weight cytochrome c	hmcA	0.0013
6459	Glycodelin	PAEP	0.0013
4034	Glutaredoxin-1	GLRX	0.0013
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0013
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0013
910	Epididymal secretory glutathione peroxidase	GPX5	0.0013
4036	Glutathione peroxidase 6	GPX6	0.0013
903	Glutathione S-transferase A5	GSTA5	0.0013
911	Glutathione peroxidase 3	GPX3	0.0013
4037	Hypothetical protein	GPX1	0.0013
4297	Hypothetical protein	SP_1951	0.0013
4521	Hypothetical protein	BC_2969	0.0013
4540	Hypothetical protein	TM_1070	0.0013
4555	Hypothetical protein	MT1739	0.0013
4569	Hypothetical protein	mshD	0.0013
4578	Hypothetical protein	PA3270	0.0013
4747	Hypothetical protein	PA3967	0.0013
5177	Hypothetical protein	TM_0096	0.0013
5194	Hypothetical protein	PA1204	0.0013
5240	Hypothetical protein	Rv2991	0.0013
5370	Hypothetical protein	TM_1158	0.0013
5710	Hypothetical protein	Tb927.5.1360	0.0013
1928	Leukotriene C4 synthase	LTC4S	0.0013
4029	Microsomal glutathione S-transferase 3	MGST3	0.0013
4032	Microsomal glutathione S-transferase 1	MGST1	0.0013
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0013
4040	Glutathione peroxidase 7	GPX7	0.0013
907	Glutathione peroxidase 2	GPX2	0.0013
906	Glutathione peroxidase 1	GPX1	0.0013
4035	Glutathione S-transferase Mu 5	GSTM5	0.0013
900	Glutathione S-transferase A4	GSTA4	0.0013
4042	Glutathione transferase omega-2	GSTO2	0.0013
4033	S-formylglutathione hydrolase	ESD	0.0013
4038	Glutathione peroxidase 4	GPX4	0.0013
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0013
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
291	Nitric-oxide synthase, endothelial	NOS3	0.0012
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
625	Glutamate carboxypeptidase 2	FOLH1	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0012
1295	Fatty acid synthase	FASN	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0012
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0011
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0011
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0011
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0011
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0011
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0011
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0011
897	Glutathione S-transferase kappa 1	GSTK1	0.0011
898	Glutathione S-transferase A3	GSTA3	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
909	Maleylacetoacetate isomerase	GSTZ1	0.0011
916	Metabotropic glutamate receptor 1	GRM1	0.0011
665	Phosphoserine aminotransferase	PSAT1	0.0011
4652	Phosphoserine aminotransferase	serC	0.0011
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0011
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0011
420	Glutamate decarboxylase 1	GAD1	0.0011
3900	Glutamate decarboxylase 1	GAD1	0.0011
4386	Hemoglobin-like protein HbN	glbN	0.0011
899	Glutathione S-transferase Mu 3	GSTM3	0.0011
905	Glutathione transferase omega-1	GSTO1	0.0011
923	Glutamate receptor 3	GRIA3	0.0011
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0011
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.001
1671	Excitatory amino acid transporter 3	SLC1A1	0.001
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.001
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.001
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.001
3877	Growth-inhibiting protein 18	GIG18	0.001
997	Protein kinase C beta type	PRKCB	0.001
426	Aspartate aminotransferase, mitochondrial	GOT2	0.001
2298	Cytochrome P450-cam	camC	0.001
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.001
3221	Cytochrome c4	cc4	0.001
2165	Glutathione S-transferase Mu 2	GSTM2	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
763	Tyrosine aminotransferase	TAT	0.001
5493	Tyrosine aminotransferase	Not Available	0.001
207	Glutathione synthetase	GSS	0.001
5269	Glutathione synthetase	gshB	0.001
251	Alcohol dehydrogenase 1A	ADH1A	0.001
76	Nitric-oxide synthase, brain	NOS1	0.001
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
2408	Tyrosine-protein kinase SYK	SYK	0.0009
901	Glutathione S-transferase Mu 4	GSTM4	0.0009
4943	Cytochrome c6	petJ	0.0009
4954	Soluble cytochrome b558	Not Available	0.0009
4916	Cyanoglobin	glbN	0.0009
4934	Cytochrome c-551	nirM	0.0009
5218	Cytochrome c-551	nirM	0.0009
4905	Cytochrome c2	Not Available	0.0009
4939	Cytochrome c2	cycA	0.0009
4964	Cytochrome c2	cycA	0.0009
4979	Cytochrome c2	cycA	0.0009
6673	Cytochrome c2	cycA	0.0009
4947	Bacterial hemoglobin	vhb	0.0009
4994	Hemoglobin-like protein HbO	glbO	0.0009
4942	Diheme cytochrome c napB	napB	0.0009
4915	Cytochrome c-550	psbV	0.0009
4959	Cytochrome c-550	psbV	0.0009
5216	Cytochrome c-550	psbV	0.0009
4925	Cytochrome c-type protein SHP	shp	0.0009
4984	Neuroglobin	NGB	0.0009
4975	Cytochrome c-556	RPA3973	0.0009
4981	Iron-starvation protein PigA	pigA	0.0009
5000	HemO	hemO	0.0009
4936	Cytochrome c2 iso-2	Not Available	0.0009
4998	Hemoglobin-like protein yjbI	yjbI	0.0009
4961	Hemophore HasA	hasA	0.0009
4909	CooA protein	cooA	0.0009
4910	Cytoglobin	CYGB	0.0009
3116	Bacterioferritin	bfr	0.0009
4906	Bacterioferritin	bfr	0.0009
4965	Bacterioferritin	bfr	0.0009
4935	Cytochrome c-554	cycA1	0.0009
644	Heme oxygenase 2	HMOX2	0.0009
4982	Heme oxygenase 2	pbsA2	0.0009
4907	Cytochrome c-L	moxG	0.0009
6865	Cytochrome c-L	moxG	0.0009
4976	Apocytochrome f	petA	0.0009
6407	Apocytochrome f	petA	0.0009
4971	Nonaheme cytochrome c	hmcA	0.0009
4937	Cytochrome oxidase subunit II	rcoxA	0.0009
4904	Cytochrome c family protein	GSU1996	0.0009
4989	Cytochrome c551 peroxidase	ccp	0.0009
5222	Cytochrome c551 peroxidase	ccpA	0.0009
4931	Cytochrome P450 167A1	CYP167A1	0.0009
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0009
4764	Cytochrome P450 165C4	CYP165C4	0.0009
4960	Putative cytochrome P450-family protein	SCO7417	0.0009
4903	Methyl-accepting chemotaxis protein	Tar4	0.0009
4999	Cytochrome P450 165B3	CYP165B3	0.0009
4972	P450cin	cinA	0.0009
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0009
4952	Catalase/peroxidase	katA	0.0009
4993	Hydroxylamine oxidoreductase	hao1	0.0009
4922	Cytochrome c, putative	SO_4144	0.0009
3093	Catalase HPII	katE	0.0009
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
820	Glycine receptor subunit alpha-2	GLRA2	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0009
444	Alcohol dehydrogenase 1B	ADH1B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
1184	Interferon beta	IFNB1	0.0008
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0008
714	Glutathione reductase, mitochondrial	GSR	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
3830	Calreticulin	CALR	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
760	Fibroblast growth factor 1	FGF1	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
4920	Peroxidase/catalase	katG	0.0007
2119	Cytochrome b5	CYB5A	0.0007
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0007
4990	PpcA	ppcA	0.0007
4988	Sulfite oxidase, mitochondrial	SUOX	0.0007
3570	Cytochrome P450 152A1	cypC	0.0007
3375	Acidic cytochrome c3	Not Available	0.0007
4289	Cytochrome P450	TT_P0059	0.0007
6262	Cytochrome P450	staP	0.0007
2915	Sensor protein fixL	fixL	0.0007
4944	Sensor protein fixL	fixL	0.0007
4992	Cytochrome c peroxidase	Not Available	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
4385	Cytochrome c'	Not Available	0.0007
4967	Cytochrome c'	cycA	0.0007
5038	Cytochrome c'	Not Available	0.0007
5223	Cytochrome c'	cycP	0.0007
4813	Heme oxygenase	hmuO	0.0007
5769	Heme oxygenase	Not Available	0.0007
1830	5'-nucleotidase	NT5E	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
125	DNA polymerase beta	POLB	0.0007
2230	Catalase	CAT	0.0007
3249	Catalase	katA	0.0007
3625	Catalase	katA	0.0007
4539	Catalase	katA	0.0007
4941	Catalase	katB	0.0007
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0006
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
442	Envelope glycoprotein	gp41	0.0006
4859	Envelope glycoprotein	env	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3670	Soluble cytochrome b562 precursor	cybC	0.0006
3411	Cytochrome P450 121	cyp121	0.0006
2617	Nitric oxide synthase oxygenase	nos	0.0006
2701	Nitric oxide synthase oxygenase	nos	0.0006
3291	Cytochrome c-552	cycA	0.0006
4927	Cytochrome c-552	nrfA	0.0006
4938	Cytochrome c-552	cycA	0.0006
4953	Cytochrome c-552	nrfA	0.0006
5217	Cytochrome c-552	cycM	0.0006
3102	Flavohemoprotein	hmp	0.0006
4969	Flavohemoprotein	hmp	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
2430	Chondroitinase B	cslB	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
4608	Putative cytochrome P450	SCO1207	0.0005
4963	Putative cytochrome P450	SCO2884	0.0005
6254	Putative cytochrome P450	SCO6998	0.0005
2427	Ferrichrome-iron receptor	fhuA	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
358	Cystathionine beta-synthase	CBS	0.0005
5961	Insulin	INS	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
693	Hemoglobin subunit beta	HBB	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
6755	Poliovirus receptor	PVR	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
958	Insulin-like growth factor 1 receptor	IGF1R	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
3689	Endoglucanase A	celA	0.0004
3814	Complement C1r subcomponent	C1R	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
1243	Cathepsin D	CTSD	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
1439	Lactotransferrin	LTF	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
4692	A/G-specific adenine glycosylase	mutY	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2802	Endoglucanase G	celCCG	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00731 - Nateglinide

Targets

Enzymes

Transporters

Carriers

Predictions